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Conserved domains on  [gi|1046869762|ref|XP_017456712|]
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exocyst complex component 3-like protein isoform X2 [Rattus norvegicus]

Protein Classification

exocyst complex component Sec6 family protein( domain architecture ID 10532741)

exocyst complex component Sec6 family protein similar to human exocyst complex component 3, which is part of the exocyst complex that is involved in the docking of exocytic vesicles with fusion sites on the plasma membrane

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sec6 pfam06046
Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 ...
 154-687 3.73e-134

Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localize to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner.


:

Pssm-ID: 428738  Cd Length: 570  Bit Score: 407.12  E-value: 3.73e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 154 FQELGLLAEALGQAVEAAAGAAGRLAREDPT-LLVAAIRVAEVETERTILGQA-----------------------PRDW 209
Cdd:pfam06046   1 FSKVDGLIEKFDKLLWEIIRNLLELVREGNTsLVVRLARIVEREEKEDEKAEAlreatkghkdmatrfsinvfrrrPRGY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 210 RQRCLRALQEGLEQLHFASPVLPEPGALSgwLEALQVA--LPAELATAEALVAPCCPPSYHVVRLWAHTLHSGLRRSLQQ 287
Cdd:pfam06046  81 KDKFLEALEESVEERFEECREKFSEDDKK--LELLYNLdwVFDDLIVVKDLLAPLFPPHWKIFKTYANIYHNALHDLLQE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 288 LLSGPELGAADTFALLHWALHvYMGKEMMGNLELgpEADVSQLEPLLTSENIEQLEAAFVAQVQVSVAQWLKKALDGEVA 367
Cdd:pfam06046 159 LVDSEELEAADILAILSWVKT-YYSKMMKGNPEL--EFDISDLGPLLGDEVLEELEDDYLSLIVNKMREWLDNLLETEVK 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 368 EWS-REQEPTTDPSGFYHSPMPAIVLQILAENIQVTSlisDSLHRRVHDMAVSELGAFLRSFSDSLIRFSRDHLRGEAVA 446
Cdd:pfam06046 236 DFTeREEPPEEDLDGYYHLPLPVDVFQMLAEQVDVAA---DSLQAKILVGVLEELAKFLRSRQDAWIELLEEELKKYMSV 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 447 ------PHYVPYLLAAFNHQSALRSSVSVLLPDGET-------SGVLAPVEAALDDVERRICRLVLEVLQAELQPLFAAL 513
Cdd:pfam06046 313 nnnespPGLVEYLIALANDQLKCADYAESLLQKYEPlkyeeriSDEFEELLDGLVDLSKECISALLDIIFNDLQPALSKL 392

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 514 PSRRWLlSSELLDSVYEQTLHFCKDFWR-VRKPAVQLLLTETERTVVLHYLRALMQGRLVCrGADERSQAAERLQHDAAQ 592
Cdd:pfam06046 393 FTKKWY-TGEVMEQIVETVEDYLNDYKEyLHPPLFQELLEELLDELVVEYLRALRGKRLKF-GAEKQEQFAEKMKRDAEQ 470

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 593 LKELFLGLGLEESAHCAPVLLALRELLN---LHDPTLLGLEVAGLRQQFPDVSEDHVSALLDLRGDVSREHRQAALSSLQ 669
Cdd:pfam06046 471 LYDFFSKLGSRDAAWLLQALRAIEDLLElleLEDPDAVPLEYETLLSSYPDISLDHVEAVLKARGDLDKSMVKALLQQLR 550

                         570       580
                  ....*....|....*....|
gi 1046869762 670 AGPPPSPSTG--RRALFSLV 687
Cdd:pfam06046 551 EIKKSYESGVepPRTIFSRV 570
 
Name Accession Description Interval E-value
Sec6 pfam06046
Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 ...
 154-687 3.73e-134

Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localize to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner.


Pssm-ID: 428738  Cd Length: 570  Bit Score: 407.12  E-value: 3.73e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 154 FQELGLLAEALGQAVEAAAGAAGRLAREDPT-LLVAAIRVAEVETERTILGQA-----------------------PRDW 209
Cdd:pfam06046   1 FSKVDGLIEKFDKLLWEIIRNLLELVREGNTsLVVRLARIVEREEKEDEKAEAlreatkghkdmatrfsinvfrrrPRGY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 210 RQRCLRALQEGLEQLHFASPVLPEPGALSgwLEALQVA--LPAELATAEALVAPCCPPSYHVVRLWAHTLHSGLRRSLQQ 287
Cdd:pfam06046  81 KDKFLEALEESVEERFEECREKFSEDDKK--LELLYNLdwVFDDLIVVKDLLAPLFPPHWKIFKTYANIYHNALHDLLQE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 288 LLSGPELGAADTFALLHWALHvYMGKEMMGNLELgpEADVSQLEPLLTSENIEQLEAAFVAQVQVSVAQWLKKALDGEVA 367
Cdd:pfam06046 159 LVDSEELEAADILAILSWVKT-YYSKMMKGNPEL--EFDISDLGPLLGDEVLEELEDDYLSLIVNKMREWLDNLLETEVK 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 368 EWS-REQEPTTDPSGFYHSPMPAIVLQILAENIQVTSlisDSLHRRVHDMAVSELGAFLRSFSDSLIRFSRDHLRGEAVA 446
Cdd:pfam06046 236 DFTeREEPPEEDLDGYYHLPLPVDVFQMLAEQVDVAA---DSLQAKILVGVLEELAKFLRSRQDAWIELLEEELKKYMSV 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 447 ------PHYVPYLLAAFNHQSALRSSVSVLLPDGET-------SGVLAPVEAALDDVERRICRLVLEVLQAELQPLFAAL 513
Cdd:pfam06046 313 nnnespPGLVEYLIALANDQLKCADYAESLLQKYEPlkyeeriSDEFEELLDGLVDLSKECISALLDIIFNDLQPALSKL 392

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 514 PSRRWLlSSELLDSVYEQTLHFCKDFWR-VRKPAVQLLLTETERTVVLHYLRALMQGRLVCrGADERSQAAERLQHDAAQ 592
Cdd:pfam06046 393 FTKKWY-TGEVMEQIVETVEDYLNDYKEyLHPPLFQELLEELLDELVVEYLRALRGKRLKF-GAEKQEQFAEKMKRDAEQ 470

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 593 LKELFLGLGLEESAHCAPVLLALRELLN---LHDPTLLGLEVAGLRQQFPDVSEDHVSALLDLRGDVSREHRQAALSSLQ 669
Cdd:pfam06046 471 LYDFFSKLGSRDAAWLLQALRAIEDLLElleLEDPDAVPLEYETLLSSYPDISLDHVEAVLKARGDLDKSMVKALLQQLR 550

                         570       580
                  ....*....|....*....|
gi 1046869762 670 AGPPPSPSTG--RRALFSLV 687
Cdd:pfam06046 551 EIKKSYESGVepPRTIFSRV 570
SEC6 COG5173
Exocyst complex subunit SEC6 [Intracellular trafficking and secretion];
251-664 7.53e-08

Exocyst complex subunit SEC6 [Intracellular trafficking and secretion];


Pssm-ID: 227500 [Multi-domain]  Cd Length: 742  Bit Score: 55.72  E-value: 7.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 251 ELATAEALVAPCCPPSYHVVRLWAHTLHSGLRRSLQQLLSgPELGAADTFALLHWAlhvymgKEMMGNLELGPEADVSQL 330
Cdd:COG5173   292 DLSFIRENISLSFPPFDNILTLYHNNYQECLLKLFTDEVT-ERLDAGEILAIIEFV------GNYYNTIESKFNFIADEV 364

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 331 EPLLTSENIEQLEAAFVAQVQVSVAQWLKKALDGEVAEW-SREQEPTTDPSGFYHSPMPAIVLQILAENIQVtslISDSL 409
Cdd:COG5173   365 GGRLLDNETGELLEKYTKLAQEKLKEWVMNLTRIEVDKFyARNEEPSRDSDGKLVLPGTVSLFQMITQQLEP---IAFTN 441

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 410 HRRVHDMAVSELGAFLRSFSDSLIRFSRDHLRG------EAVAPH-YVPYLLAAFNHQ-------SALRSSVSVLLPDGE 475
Cdd:COG5173   442 RSDVVGIVFAHITRTITKYQEIWKSNLVEEMDKqfksnpESSSPAgLEEYLIAVGNDGlkiaqyiTSLPSNTFELITSEY 521

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 476 TSGVLAPVEAALD---DVERRICRLVLEVLQAELQPLFAALPSRRWLLSselldSVYEQTLHFCKDFWRVRKPAVQ---- 548
Cdd:COG5173   522 ENDEVKELGKTVDgfiDILKASNTFLAEFIIYDCQPAIDKIFTDEWYGG-----SVTKVIVDTLQDYLSDYQNTMSeylf 596

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 549 -LLLTETERTVVLHYLRALMQGRlVCRGADERSQAaerLQHDAAQLKELFLGLG-LEESAHC-APVLLALRELLNLHDPT 625
Cdd:COG5173   597 vTFIHELSMSIVIAYLKQLGRKR-ASIAEENASRT---LKSDHTKLYEMFSGYGdPEDVKTTlSPILKIIPLMDTRNDDL 672

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1046869762 626 LLgLEVAGLRQQFPDVSEDHVSALLDLRGDVSREHRQAA 664
Cdd:COG5173   673 FI-VEVKSLKEIYWDIKKSLIKTILKKRQDLTESIIQKK 710
 
Name Accession Description Interval E-value
Sec6 pfam06046
Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 ...
 154-687 3.73e-134

Exocyst complex component Sec6; Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localize to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner.


Pssm-ID: 428738  Cd Length: 570  Bit Score: 407.12  E-value: 3.73e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 154 FQELGLLAEALGQAVEAAAGAAGRLAREDPT-LLVAAIRVAEVETERTILGQA-----------------------PRDW 209
Cdd:pfam06046   1 FSKVDGLIEKFDKLLWEIIRNLLELVREGNTsLVVRLARIVEREEKEDEKAEAlreatkghkdmatrfsinvfrrrPRGY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 210 RQRCLRALQEGLEQLHFASPVLPEPGALSgwLEALQVA--LPAELATAEALVAPCCPPSYHVVRLWAHTLHSGLRRSLQQ 287
Cdd:pfam06046  81 KDKFLEALEESVEERFEECREKFSEDDKK--LELLYNLdwVFDDLIVVKDLLAPLFPPHWKIFKTYANIYHNALHDLLQE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 288 LLSGPELGAADTFALLHWALHvYMGKEMMGNLELgpEADVSQLEPLLTSENIEQLEAAFVAQVQVSVAQWLKKALDGEVA 367
Cdd:pfam06046 159 LVDSEELEAADILAILSWVKT-YYSKMMKGNPEL--EFDISDLGPLLGDEVLEELEDDYLSLIVNKMREWLDNLLETEVK 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 368 EWS-REQEPTTDPSGFYHSPMPAIVLQILAENIQVTSlisDSLHRRVHDMAVSELGAFLRSFSDSLIRFSRDHLRGEAVA 446
Cdd:pfam06046 236 DFTeREEPPEEDLDGYYHLPLPVDVFQMLAEQVDVAA---DSLQAKILVGVLEELAKFLRSRQDAWIELLEEELKKYMSV 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 447 ------PHYVPYLLAAFNHQSALRSSVSVLLPDGET-------SGVLAPVEAALDDVERRICRLVLEVLQAELQPLFAAL 513
Cdd:pfam06046 313 nnnespPGLVEYLIALANDQLKCADYAESLLQKYEPlkyeeriSDEFEELLDGLVDLSKECISALLDIIFNDLQPALSKL 392

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 514 PSRRWLlSSELLDSVYEQTLHFCKDFWR-VRKPAVQLLLTETERTVVLHYLRALMQGRLVCrGADERSQAAERLQHDAAQ 592
Cdd:pfam06046 393 FTKKWY-TGEVMEQIVETVEDYLNDYKEyLHPPLFQELLEELLDELVVEYLRALRGKRLKF-GAEKQEQFAEKMKRDAEQ 470

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 593 LKELFLGLGLEESAHCAPVLLALRELLN---LHDPTLLGLEVAGLRQQFPDVSEDHVSALLDLRGDVSREHRQAALSSLQ 669
Cdd:pfam06046 471 LYDFFSKLGSRDAAWLLQALRAIEDLLElleLEDPDAVPLEYETLLSSYPDISLDHVEAVLKARGDLDKSMVKALLQQLR 550

                         570       580
                  ....*....|....*....|
gi 1046869762 670 AGPPPSPSTG--RRALFSLV 687
Cdd:pfam06046 551 EIKKSYESGVepPRTIFSRV 570
SEC6 COG5173
Exocyst complex subunit SEC6 [Intracellular trafficking and secretion];
251-664 7.53e-08

Exocyst complex subunit SEC6 [Intracellular trafficking and secretion];


Pssm-ID: 227500 [Multi-domain]  Cd Length: 742  Bit Score: 55.72  E-value: 7.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 251 ELATAEALVAPCCPPSYHVVRLWAHTLHSGLRRSLQQLLSgPELGAADTFALLHWAlhvymgKEMMGNLELGPEADVSQL 330
Cdd:COG5173   292 DLSFIRENISLSFPPFDNILTLYHNNYQECLLKLFTDEVT-ERLDAGEILAIIEFV------GNYYNTIESKFNFIADEV 364

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 331 EPLLTSENIEQLEAAFVAQVQVSVAQWLKKALDGEVAEW-SREQEPTTDPSGFYHSPMPAIVLQILAENIQVtslISDSL 409
Cdd:COG5173   365 GGRLLDNETGELLEKYTKLAQEKLKEWVMNLTRIEVDKFyARNEEPSRDSDGKLVLPGTVSLFQMITQQLEP---IAFTN 441

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 410 HRRVHDMAVSELGAFLRSFSDSLIRFSRDHLRG------EAVAPH-YVPYLLAAFNHQ-------SALRSSVSVLLPDGE 475
Cdd:COG5173   442 RSDVVGIVFAHITRTITKYQEIWKSNLVEEMDKqfksnpESSSPAgLEEYLIAVGNDGlkiaqyiTSLPSNTFELITSEY 521

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 476 TSGVLAPVEAALD---DVERRICRLVLEVLQAELQPLFAALPSRRWLLSselldSVYEQTLHFCKDFWRVRKPAVQ---- 548
Cdd:COG5173   522 ENDEVKELGKTVDgfiDILKASNTFLAEFIIYDCQPAIDKIFTDEWYGG-----SVTKVIVDTLQDYLSDYQNTMSeylf 596

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046869762 549 -LLLTETERTVVLHYLRALMQGRlVCRGADERSQAaerLQHDAAQLKELFLGLG-LEESAHC-APVLLALRELLNLHDPT 625
Cdd:COG5173   597 vTFIHELSMSIVIAYLKQLGRKR-ASIAEENASRT---LKSDHTKLYEMFSGYGdPEDVKTTlSPILKIIPLMDTRNDDL 672

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1046869762 626 LLgLEVAGLRQQFPDVSEDHVSALLDLRGDVSREHRQAA 664
Cdd:COG5173   673 FI-VEVKSLKEIYWDIKKSLIKTILKKRQDLTESIIQKK 710
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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