LIM domain-binding protein 2 isoform X4 [Rattus norvegicus]
Protein Classification
LIM domain-binding protein( domain architecture ID 10485175)
LIM domain-binding protein binds to the LIM domain of LIM homeodomain proteins, which are transcriptional regulators of development; similar to Arabidopsis thaliana transcriptional corepressor SEUSS
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| LIM_bind | pfam01803 | LIM-domain binding protein; The LIM-domain binding protein, binds to the LIM domain pfam00412 ... |
31-232 | 4.28e-32 | |||||
LIM-domain binding protein; The LIM-domain binding protein, binds to the LIM domain pfam00412 of LIM homeodomain proteins which are transcriptional regulators of development. Nuclear LIM interactor (NLI) / LIM domain-binding protein 1 (LDB1) is located in the nuclei of neuronal cells during development, it is co-expressed with Isl1 in early motor neuron differentiation and has a suggested role in the Isl1 dependent development of motor neurons. It is suggested that these proteins act synergistically to enhance transcriptional efficiency by acting as co-factors for LIM homeodomain and Otx class transcription factors both of which have essential roles in development. The Drosophila protein Chip is required for segmentation and activity of a remote wing margin enhancer. Chip is a ubiquitous chromosomal factor required for normal expression of diverse genes at many stages of development. It is suggested that Chip cooperates with different LIM domain proteins and other factors to structurally support remote enhancer-promoter interactions. : Pssm-ID: 426444 Cd Length: 242 Bit Score: 119.69 E-value: 4.28e-32
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| Name | Accession | Description | Interval | E-value | |||||
| LIM_bind | pfam01803 | LIM-domain binding protein; The LIM-domain binding protein, binds to the LIM domain pfam00412 ... |
31-232 | 4.28e-32 | |||||
LIM-domain binding protein; The LIM-domain binding protein, binds to the LIM domain pfam00412 of LIM homeodomain proteins which are transcriptional regulators of development. Nuclear LIM interactor (NLI) / LIM domain-binding protein 1 (LDB1) is located in the nuclei of neuronal cells during development, it is co-expressed with Isl1 in early motor neuron differentiation and has a suggested role in the Isl1 dependent development of motor neurons. It is suggested that these proteins act synergistically to enhance transcriptional efficiency by acting as co-factors for LIM homeodomain and Otx class transcription factors both of which have essential roles in development. The Drosophila protein Chip is required for segmentation and activity of a remote wing margin enhancer. Chip is a ubiquitous chromosomal factor required for normal expression of diverse genes at many stages of development. It is suggested that Chip cooperates with different LIM domain proteins and other factors to structurally support remote enhancer-promoter interactions. Pssm-ID: 426444 Cd Length: 242 Bit Score: 119.69 E-value: 4.28e-32
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| Name | Accession | Description | Interval | E-value | |||||
| LIM_bind | pfam01803 | LIM-domain binding protein; The LIM-domain binding protein, binds to the LIM domain pfam00412 ... |
31-232 | 4.28e-32 | |||||
LIM-domain binding protein; The LIM-domain binding protein, binds to the LIM domain pfam00412 of LIM homeodomain proteins which are transcriptional regulators of development. Nuclear LIM interactor (NLI) / LIM domain-binding protein 1 (LDB1) is located in the nuclei of neuronal cells during development, it is co-expressed with Isl1 in early motor neuron differentiation and has a suggested role in the Isl1 dependent development of motor neurons. It is suggested that these proteins act synergistically to enhance transcriptional efficiency by acting as co-factors for LIM homeodomain and Otx class transcription factors both of which have essential roles in development. The Drosophila protein Chip is required for segmentation and activity of a remote wing margin enhancer. Chip is a ubiquitous chromosomal factor required for normal expression of diverse genes at many stages of development. It is suggested that Chip cooperates with different LIM domain proteins and other factors to structurally support remote enhancer-promoter interactions. Pssm-ID: 426444 Cd Length: 242 Bit Score: 119.69 E-value: 4.28e-32
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