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Conserved domains on  [gi|1046903893|ref|XP_017451859|]
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mitochondrial chaperone BCS1 isoform X1 [Rattus norvegicus]

Protein Classification

mitochondrial chaperone BCS1( domain architecture ID 16123122)

mitochondrial chaperone BCS1, an AAA (ATPases Associated with diverse cellular Activities) protein of the mitochondria with a role in the biogenesis of the respiratory chain

CATH:  3.40.50.300
Gene Ontology:  GO:0016020|GO:0005524|GO:0016887
PubMed:  31988523|24361883|22575765|31988523
TCDB:  3.A.28

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 201-353 2.55e-91

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


:

Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 272.30  E-value: 2.55e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 201 IVKDIREFIDNPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGELEHSICLLSLTDSSLSDDRLNHLLSVAPQQSLVL 280
Cdd:cd19510     1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEVVLTDDRLNHLLNTAPKQSIIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1046903893 281 LEDVDAAFLSRDLAVENPVKYQGLGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVDLKEYV 353
Cdd:cd19510    81 LEDIDAAFESREHNKKNPSAYGGLSRVTFSGLLNALDGVASSEERIVFMTTNHIERLDPALIRPGRVDMKIYM 153
BCS1_N smart01024
This domain is found at the N terminal of the mitochondrial ATPase BCS1. It encodes the import ...
 24-191 4.98e-81

This domain is found at the N terminal of the mitochondrial ATPase BCS1. It encodes the import and intramitochondrial sorting for the protein;


:

Pssm-ID: 214980  Cd Length: 170  Bit Score: 246.76  E-value: 4.98e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893   24 GVGTALAMARKGAQLGLVAFRRHYMITLEVPARDRSYAWLLSWLTRH--STRTQHLSVETSYLQHESGRISTKFEFIPSP 101
Cdd:smart01024   2 LLGAAGAFLRRGISVAASLIRRRFLVTLEVPSKDESYAWLLEWLSQQpfRQRSRHLSVETSYTQHDNGKSSTSFSFVPGP 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893  102 GNHFIWYQGKWIRVERNREMQMVDLQTGTPWESVTFTALGTDRKVFFNILEEARALALQQEEGKTVMYTAVGSEWRTFgY 181
Cdd:smart01024  82 GTHWFWYKGRWIWVTREREKTMADMRTGSPFETLTLTTLGRDRDVFKELLEEARELALKRTEGKTVIYTADGPEWRRF-A 160

                          170
                   ....*....|
gi 1046903893  182 PRRRRPLDSV 191
Cdd:smart01024 161 PRRKRPLSSV 170
 
Name Accession Description Interval E-value
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 201-353 2.55e-91

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 272.30  E-value: 2.55e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 201 IVKDIREFIDNPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGELEHSICLLSLTDSSLSDDRLNHLLSVAPQQSLVL 280
Cdd:cd19510     1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEVVLTDDRLNHLLNTAPKQSIIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1046903893 281 LEDVDAAFLSRDLAVENPVKYQGLGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVDLKEYV 353
Cdd:cd19510    81 LEDIDAAFESREHNKKNPSAYGGLSRVTFSGLLNALDGVASSEERIVFMTTNHIERLDPALIRPGRVDMKIYM 153
BCS1_N smart01024
This domain is found at the N terminal of the mitochondrial ATPase BCS1. It encodes the import ...
 24-191 4.98e-81

This domain is found at the N terminal of the mitochondrial ATPase BCS1. It encodes the import and intramitochondrial sorting for the protein;


Pssm-ID: 214980  Cd Length: 170  Bit Score: 246.76  E-value: 4.98e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893   24 GVGTALAMARKGAQLGLVAFRRHYMITLEVPARDRSYAWLLSWLTRH--STRTQHLSVETSYLQHESGRISTKFEFIPSP 101
Cdd:smart01024   2 LLGAAGAFLRRGISVAASLIRRRFLVTLEVPSKDESYAWLLEWLSQQpfRQRSRHLSVETSYTQHDNGKSSTSFSFVPGP 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893  102 GNHFIWYQGKWIRVERNREMQMVDLQTGTPWESVTFTALGTDRKVFFNILEEARALALQQEEGKTVMYTAVGSEWRTFgY 181
Cdd:smart01024  82 GTHWFWYKGRWIWVTREREKTMADMRTGSPFETLTLTTLGRDRDVFKELLEEARELALKRTEGKTVIYTADGPEWRRF-A 160

                          170
                   ....*....|
gi 1046903893  182 PRRRRPLDSV 191
Cdd:smart01024 161 PRRKRPLSSV 170
BCS1_N pfam08740
BCS1 N terminal; This domain is found at the N terminal of the mitochondrial ATPase BSC1. It ...
 25-191 4.24e-54

BCS1 N terminal; This domain is found at the N terminal of the mitochondrial ATPase BSC1. It encodes the import and intramitochondrial sorting for the protein.


Pssm-ID: 462583  Cd Length: 178  Bit Score: 177.44  E-value: 4.24e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893  25 VGTALAMARKGAQLGLVAFRRHYMITLEVPARDRSYAWLLSWLTRH--STRTQHLSVETSYLQH------ESGRISTKFE 96
Cdd:pfam08740   1 LGALLAALRRGLRSLWSLLRRRFLSTVEIRSDDESYDWVLAWLSQQpfWRRSRSLSAETRTNSRsdddddDDGSKKKPLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893  97 FIPSPGNHFIWYQGKWIRVERNREMQMVDLQTGTPWESVTFTALGTDRKVFFNILEEARALALQQEEGKTVMYTAV---- 172
Cdd:pfam08740  81 YTPGFGTHYFWYKGRWFAVSRERESSSSDLATGSPRETLTLSCLGRSPEPLKELLEEARELYLKKDEGKTVIYRAWrdgy 160

                         170
                  ....*....|....*....
gi 1046903893 173 GSEWRTFGYpRRRRPLDSV 191
Cdd:pfam08740 161 GGSWRRVGS-RPKRPLSTV 178
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 226-355 2.78e-19

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 83.41  E-value: 2.78e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 226 YLLYGPPGCGKSSFITALAGEL-----EHSICLLSLTDSSLSDDRLNHLLSVAPQQ--SLVLLEDVDAAFLSRDlavenp 298
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELgapfiEISGSELVSKYVGESEKRLRELFEAAKKLapCVIFIDEIDALAGSRG------ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1046903893 299 VKYQGLGRLTFSGLLNALDGVASTEAR-IVFMTTNHIDRLDPALIrpGRVDLKEYVGY 355
Cdd:pfam00004  75 SGGDSESRRVVNQLLTELDGFTSSNSKvIVIAATNRPDKLDPALL--GRFDRIIEFPL 130
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 196-354 1.07e-17

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 83.52  E-value: 1.07e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 196 GLaDRIVKDIREFID----NPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGELEHSIcllsltdsslSDDRLNHLLS 271
Cdd:COG1222    82 GL-DEQIEEIREAVElplkNPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPF----------IRVRGSELVS 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 272 -------------------VAPqqSLVLLEDVDAAFLSRDLAVENpvkyqGLGRLTFSGLLNALDGVASTEARIVFMTTN 332
Cdd:COG1222   151 kyigegarnvrevfelareKAP--SIIFIDEIDAIAARRTDDGTS-----GEVQRTVNQLLAELDGFESRGDVLIIAATN 223

                         170       180
                  ....*....|....*....|..
gi 1046903893 333 HIDRLDPALIRPGRVDLKEYVG 354
Cdd:COG1222   224 RPDLLDPALLRPGRFDRVIEVP 245
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 185-350 6.67e-14

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 72.88  E-value: 6.67e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 185 RRPLDSVVLQQGLADRI--VKDIREF-IDNPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGELEHSICLLSLTDSSL 261
Cdd:PTZ00361  176 KAPLESYADIGGLEQQIqeIKEAVELpLTHPELYDDIGIKPPKGVILYGPPGTGKTLLAKAVANETSATFLRVVGSELIQ 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 262 SDD-----RLNHLLSVAPQQ--SLVLLEDVDAAFLSR---DLAVENPVKYqglgrlTFSGLLNALDGVASTEARIVFMTT 331
Cdd:PTZ00361  256 KYLgdgpkLVRELFRVAEENapSIVFIDEIDAIGTKRydaTSGGEKEIQR------TMLELLNQLDGFDSRGDVKVIMAT 329

                         170
                  ....*....|....*....
gi 1046903893 332 NHIDRLDPALIRPGRVDLK 350
Cdd:PTZ00361  330 NRIESLDPALIRPGRIDRK 348
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 202-348 3.68e-10

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 61.85  E-value: 3.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 202 VKDIREFID----NPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGELEHSICLL-----SLTDSSLSDDRLNHLLSV 272
Cdd:TIGR01243 187 KEKIREMVElpmkHPELFEHLGIEPPKGVLLYGPPGTGKTLLAKAVANEAGAYFISIngpeiMSKYYGESEERLREIFKE 266

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1046903893 273 APQQ--SLVLLEDVDAAFLSRDLAVENpvkyqgLGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVD 348
Cdd:TIGR01243 267 AEENapSIIFIDEIDAIAPKREEVTGE------VEKRVVAQLLTLMDGLKGRGRVIVIGATNRPDALDPALRRPGRFD 338
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 223-354 5.53e-06

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 45.83  E-value: 5.53e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893  223 RRGYLLYGPPGCGKSSFITALAGEL------------EHSICLLSLTDSSLSDDRLNHLLSVA------------PQQSL 278
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELgppgggviyidgEDILEEVLDQLLLIIVGGKKASGSGElrlrlalalarkLKPDV 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1046903893  279 VLLEDVDAAflsrdlavenpVKYQGLGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPgRVDLKEYVG 354
Cdd:smart00382  82 LILDEITSL-----------LDAEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLL 145
cell_div_CdvC NF041006
cell division protein CdvC;
224-248 5.33e-04

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 42.03  E-value: 5.33e-04
                          10        20
                  ....*....|....*....|....*
gi 1046903893 224 RGYLLYGPPGCGKSSFITALAGELE 248
Cdd:NF041006  135 RGILLYGPPGCGKTMLAAAVANEID 159
 
Name Accession Description Interval E-value
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 201-353 2.55e-91

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 272.30  E-value: 2.55e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 201 IVKDIREFIDNPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGELEHSICLLSLTDSSLSDDRLNHLLSVAPQQSLVL 280
Cdd:cd19510     1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEVVLTDDRLNHLLNTAPKQSIIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1046903893 281 LEDVDAAFLSRDLAVENPVKYQGLGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVDLKEYV 353
Cdd:cd19510    81 LEDIDAAFESREHNKKNPSAYGGLSRVTFSGLLNALDGVASSEERIVFMTTNHIERLDPALIRPGRVDMKIYM 153
BCS1_N smart01024
This domain is found at the N terminal of the mitochondrial ATPase BCS1. It encodes the import ...
 24-191 4.98e-81

This domain is found at the N terminal of the mitochondrial ATPase BCS1. It encodes the import and intramitochondrial sorting for the protein;


Pssm-ID: 214980  Cd Length: 170  Bit Score: 246.76  E-value: 4.98e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893   24 GVGTALAMARKGAQLGLVAFRRHYMITLEVPARDRSYAWLLSWLTRH--STRTQHLSVETSYLQHESGRISTKFEFIPSP 101
Cdd:smart01024   2 LLGAAGAFLRRGISVAASLIRRRFLVTLEVPSKDESYAWLLEWLSQQpfRQRSRHLSVETSYTQHDNGKSSTSFSFVPGP 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893  102 GNHFIWYQGKWIRVERNREMQMVDLQTGTPWESVTFTALGTDRKVFFNILEEARALALQQEEGKTVMYTAVGSEWRTFgY 181
Cdd:smart01024  82 GTHWFWYKGRWIWVTREREKTMADMRTGSPFETLTLTTLGRDRDVFKELLEEARELALKRTEGKTVIYTADGPEWRRF-A 160

                          170
                   ....*....|
gi 1046903893  182 PRRRRPLDSV 191
Cdd:smart01024 161 PRRKRPLSSV 170
BCS1_N pfam08740
BCS1 N terminal; This domain is found at the N terminal of the mitochondrial ATPase BSC1. It ...
 25-191 4.24e-54

BCS1 N terminal; This domain is found at the N terminal of the mitochondrial ATPase BSC1. It encodes the import and intramitochondrial sorting for the protein.


Pssm-ID: 462583  Cd Length: 178  Bit Score: 177.44  E-value: 4.24e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893  25 VGTALAMARKGAQLGLVAFRRHYMITLEVPARDRSYAWLLSWLTRH--STRTQHLSVETSYLQH------ESGRISTKFE 96
Cdd:pfam08740   1 LGALLAALRRGLRSLWSLLRRRFLSTVEIRSDDESYDWVLAWLSQQpfWRRSRSLSAETRTNSRsdddddDDGSKKKPLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893  97 FIPSPGNHFIWYQGKWIRVERNREMQMVDLQTGTPWESVTFTALGTDRKVFFNILEEARALALQQEEGKTVMYTAV---- 172
Cdd:pfam08740  81 YTPGFGTHYFWYKGRWFAVSRERESSSSDLATGSPRETLTLSCLGRSPEPLKELLEEARELYLKKDEGKTVIYRAWrdgy 160

                         170
                  ....*....|....*....
gi 1046903893 173 GSEWRTFGYpRRRRPLDSV 191
Cdd:pfam08740 161 GGSWRRVGS-RPKRPLSTV 178
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 201-350 4.21e-34

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 124.70  E-value: 4.21e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 201 IVKDIREFIDNPKWYID---RGIPYRRGYLLYGPPGCGKSSFITALAGELEH-----SICLLSLTDSSLSDDRLNHLLSV 272
Cdd:cd19481     1 LKASLREAVEAPRRGSRlrrYGLGLPKGILLYGPPGTGKTLLAKALAGELGLplivvKLSSLLSKYVGESEKNLRKIFER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 273 APQQ--SLVLLEDVDAAFLSRDLAVENPVkyqglGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVDLK 350
Cdd:cd19481    81 ARRLapCILFIDEIDAIGRKRDSSGESGE-----LRRVLNQLLTELDGVNSRSKVLVIAATNRPDLLDPALLRPGRFDEV 155
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 226-355 2.78e-19

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 83.41  E-value: 2.78e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 226 YLLYGPPGCGKSSFITALAGEL-----EHSICLLSLTDSSLSDDRLNHLLSVAPQQ--SLVLLEDVDAAFLSRDlavenp 298
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELgapfiEISGSELVSKYVGESEKRLRELFEAAKKLapCVIFIDEIDALAGSRG------ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1046903893 299 VKYQGLGRLTFSGLLNALDGVASTEAR-IVFMTTNHIDRLDPALIrpGRVDLKEYVGY 355
Cdd:pfam00004  75 SGGDSESRRVVNQLLTELDGFTSSNSKvIVIAATNRPDKLDPALL--GRFDRIIEFPL 130
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 196-354 1.07e-17

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 83.52  E-value: 1.07e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 196 GLaDRIVKDIREFID----NPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGELEHSIcllsltdsslSDDRLNHLLS 271
Cdd:COG1222    82 GL-DEQIEEIREAVElplkNPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPF----------IRVRGSELVS 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 272 -------------------VAPqqSLVLLEDVDAAFLSRDLAVENpvkyqGLGRLTFSGLLNALDGVASTEARIVFMTTN 332
Cdd:COG1222   151 kyigegarnvrevfelareKAP--SIIFIDEIDAIAARRTDDGTS-----GEVQRTVNQLLAELDGFESRGDVLIIAATN 223

                         170       180
                  ....*....|....*....|..
gi 1046903893 333 HIDRLDPALIRPGRVDLKEYVG 354
Cdd:COG1222   224 RPDLLDPALLRPGRFDRVIEVP 245
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 196-348 3.69e-15

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 72.71  E-value: 3.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 196 GLADRIVKdIREFID----NPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGELE--------HSIcllSLTDSSLSD 263
Cdd:cd19503     4 GLDEQIAS-LKELIElplkYPELFRALGLKPPRGVLLHGPPGTGKTLLARAVANEAGanflsisgPSI---VSKYLGESE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 264 DRLNHLLSVAP--QQSLVLLEDVDAAFLSRDLAVEnpvkyqGLGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPAL 341
Cdd:cd19503    80 KNLREIFEEARshAPSIIFIDEIDALAPKREEDQR------EVERRVVAQLLTLMDGMSSRGKVVVIAATNRPDAIDPAL 153


                  ....*..
gi 1046903893 342 IRPGRVD 348
Cdd:cd19503   154 RRPGRFD 160
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 184-396 7.80e-15

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 75.72  E-value: 7.80e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 184 RRRPLDSVVLQQGLADRIVKDIREFIDNPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGELE--------------- 248
Cdd:COG0464   152 REAILDDLGGLEEVKEELRELVALPLKRPELREEYGLPPPRGLLLYGPPGTGKTLLARALAGELGlplievdlsdlvsky 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 249 --HSicllsltdsslsDDRLNHLLSVAPQQS--LVLLEDVDAAFLSRDLAVEnpvkyqGLGRLTFSGLLNALDGVasTEA 324
Cdd:COG0464   232 vgET------------EKNLREVFDKARGLApcVLFIDEADALAGKRGEVGD------GVGRRVVNTLLTEMEEL--RSD 291

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046903893 325 RIVFMTTNHIDRLDPALIRpgRVDLKEYVGYCSHWQLTQMFQRFYPGQAPSLAENFAEhVLKATSQISPAQV 396
Cdd:COG0464   292 VVVIAATNRPDLLDPALLR--RFDEIIFFPLPDAEERLEIFRIHLRKRPLDEDVDLEE-LAEATEGLSGADI 360
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 196-348 1.78e-14

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 70.90  E-value: 1.78e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 196 GLADRIVKDIREF----IDNPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGEL-----EHSICLLSLTDSSLSDDRL 266
Cdd:cd19518     3 GGMDSTLKELCELlihpILPPEYFQHLGVEPPRGVLLHGPPGCGKTMLANAIAGELkvpflKISATEIVSGVSGESEEKI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 267 NHLLSVAPQQS--LVLLEDVDAAFLSRDLAVENpvkyqgLGRLTFSGLLNALDGV----ASTEARIVFMTTNHIDRLDPA 340
Cdd:cd19518    83 RELFDQAISNApcIVFIDEIDAITPKRESAQRE------MERRIVSQLLTCMDELnnekTAGGPVLVIGATNRPDSLDPA 156


                  ....*...
gi 1046903893 341 LIRPGRVD 348
Cdd:cd19518   157 LRRAGRFD 164
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 185-350 6.67e-14

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 72.88  E-value: 6.67e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 185 RRPLDSVVLQQGLADRI--VKDIREF-IDNPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGELEHSICLLSLTDSSL 261
Cdd:PTZ00361  176 KAPLESYADIGGLEQQIqeIKEAVELpLTHPELYDDIGIKPPKGVILYGPPGTGKTLLAKAVANETSATFLRVVGSELIQ 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 262 SDD-----RLNHLLSVAPQQ--SLVLLEDVDAAFLSR---DLAVENPVKYqglgrlTFSGLLNALDGVASTEARIVFMTT 331
Cdd:PTZ00361  256 KYLgdgpkLVRELFRVAEENapSIVFIDEIDAIGTKRydaTSGGEKEIQR------TMLELLNQLDGFDSRGDVKVIMAT 329

                         170
                  ....*....|....*....
gi 1046903893 332 NHIDRLDPALIRPGRVDLK 350
Cdd:PTZ00361  330 NRIESLDPALIRPGRIDRK 348
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 202-353 6.95e-14

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 69.18  E-value: 6.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 202 VKDIREFIDNPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGE-----LEHSICLLSLTDSSLSDDRLNHLLSVAPQQ 276
Cdd:cd19501    16 LKEVVEFLKNPEKFTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEagvpfFSISGSDFVEMFVGVGASRVRDLFEQAKKN 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 277 S--LVLLEDVDAAFLSRDLAV--ENPVKYQglgrlTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVDLKEY 352
Cdd:cd19501    96 ApcIVFIDEIDAVGRKRGAGLggGHDEREQ-----TLNQLLVEMDGFESNTGVIVIAATNRPDVLDPALLRPGRFDRQVY 170


                  .
gi 1046903893 353 V 353
Cdd:cd19501   171 V 171
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 196-350 1.80e-13

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 68.13  E-value: 1.80e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 196 GLADRIvKDIREFID----NPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGELE----HSICLLSLTDSSLSDDRLN 267
Cdd:cd19502     7 GLDEQI-REIREVVElplkHPELFEELGIEPPKGVLLYGPPGTGKTLLAKAVANHTDatfiRVVGSELVQKYIGEGARLV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 268 H-LLSVAPQQ--SLVLLEDVDAAFLSR---DLAVENPVKYqglgrlTFSGLLNALDGVASTEARIVFMTTNHIDRLDPAL 341
Cdd:cd19502    86 ReLFEMAREKapSIIFIDEIDAIGAKRfdsGTGGDREVQR------TMLELLNQLDGFDPRGNIKVIMATNRPDILDPAL 159


                  ....*....
gi 1046903893 342 IRPGRVDLK 350
Cdd:cd19502   160 LRPGRFDRK 168
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 219-353 1.34e-11

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 62.30  E-value: 1.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 219 GIPYRRGYLLYGPPGCGKSSFITALAGElehsicllsltdsslsdDRLN-------HLLS-------------------V 272
Cdd:cd19511    23 GIRPPKGVLLYGPPGCGKTLLAKALASE-----------------AGLNfisvkgpELFSkyvgeseravreifqkarqA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 273 APqqSLVLLEDVDAAFLSRDLAVENPVKYQGLgrltfSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVDLKEY 352
Cdd:cd19511    86 AP--CIIFFDEIDSLAPRRGQSDSSGVTDRVV-----SQLLTELDGIESLKGVVVIAATNRPDMIDPALLRPGRLDKLIY 158


                  .
gi 1046903893 353 V 353
Cdd:cd19511   159 V 159
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 209-353 5.47e-11

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 60.60  E-value: 5.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 209 IDNPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGELEHSICLLSLTDSSL-----SDDRLNHLLSVAPQQS--LVLL 281
Cdd:cd19528    13 VEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTmwfgeSEANVRDIFDKARAAApcVLFF 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046903893 282 EDVDAAFLSRDLAVENPvkyQGLGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVDLKEYV 353
Cdd:cd19528    93 DELDSIAKARGGNIGDA---GGAADRVINQILTEMDGMNTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYI 161
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 202-348 3.68e-10

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 61.85  E-value: 3.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 202 VKDIREFID----NPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGELEHSICLL-----SLTDSSLSDDRLNHLLSV 272
Cdd:TIGR01243 187 KEKIREMVElpmkHPELFEHLGIEPPKGVLLYGPPGTGKTLLAKAVANEAGAYFISIngpeiMSKYYGESEERLREIFKE 266

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1046903893 273 APQQ--SLVLLEDVDAAFLSRDLAVENpvkyqgLGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVD 348
Cdd:TIGR01243 267 AEENapSIIFIDEIDAIAPKREEVTGE------VEKRVVAQLLTLMDGLKGRGRVIVIGATNRPDALDPALRRPGRFD 338
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 212-353 3.96e-10

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 58.28  E-value: 3.96e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 212 PKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGElehsicllslTDSSLSDDRLNHLLS-------------------V 272
Cdd:cd19529    16 PEVFKRLGIRPPKGILLYGPPGTGKTLLAKAVATE----------SNANFISVKGPELLSkwvgesekaireifrkarqV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 273 APqqSLVLLEDVDAAFLSRDLAVENPVKYQGLGRltfsgLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVDLKEY 352
Cdd:cd19529    86 AP--CVIFFDEIDSIAPRRGTTGDSGVTERVVNQ-----LLTELDGLEEMNGVVVIAATNRPDIIDPALLRAGRFDRLIY 158


                  .
gi 1046903893 353 V 353
Cdd:cd19529   159 I 159
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 202-348 4.45e-10

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 58.22  E-value: 4.45e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 202 VKDIREFID----NPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGELEHSICLL-----SLTDSSLSDDRLNHLLSV 272
Cdd:cd19519     9 LAQIREMVElplrHPELFKAIGIKPPRGILLYGPPGTGKTLIARAVANETGAFFFLIngpeiMSKLAGESESNLRKAFEE 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046903893 273 APQQ--SLVLLEDVDAAFLSRDlavenpvKYQG-LGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVD 348
Cdd:cd19519    89 AEKNapAIIFIDEIDAIAPKRE-------KTHGeVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFD 160
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
202-354 6.18e-10

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 61.20  E-value: 6.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 202 VKDIREFIDNPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGE-----LEHSICLLSLTDSSLSDDRLNHLLSVAPQQ 276
Cdd:PRK10733  164 VAELVEYLREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEakvpfFTISGSDFVEMFVGVGASRVRDMFEQAKKA 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 277 S--LVLLEDVDAAFLSRDlavenpvkyQGLG------RLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVD 348
Cdd:PRK10733  244 ApcIIFIDEIDAVGRQRG---------AGLGgghderEQTLNQMLVEMDGFEGNEGIIVIAATNRPDVLDPALLRPGRFD 314


                  ....*.
gi 1046903893 349 LKEYVG 354
Cdd:PRK10733  315 RQVVVG 320
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 188-353 8.02e-10

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 57.50  E-value: 8.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 188 LDSVVLQqgLADRIVKDIRefidNPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALA--------------------GEL 247
Cdd:cd19530     1 LDHVREE--LTMSILRPIK----RPDIYKALGIDLPTGVLLYGPPGCGKTLLAKAVAnesganfisvkgpellnkyvGES 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 248 EHSIcllsltdsslsddRLNHLLSVAPQQSLVLLEDVDAAFLSRDLAVEnpvkyQGLGRLTfSGLLNALDGVASTEARIV 327
Cdd:cd19530    75 ERAV-------------RQVFQRARASAPCVIFFDEVDALVPKRGDGGS-----WASERVV-NQLLTEMDGLEERSNVFV 135

                         170       180
                  ....*....|....*....|....*.
gi 1046903893 328 FMTTNHIDRLDPALIRPGRVDLKEYV 353
Cdd:cd19530   136 IAATNRPDIIDPAMLRPGRLDKTLYV 161
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 212-348 8.85e-10

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 57.05  E-value: 8.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 212 PKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGELEHSICLLSLTDSslsddrLNHLLSVAPQQSLVLLEDVDAA---- 287
Cdd:cd19526    16 PKIFASSPLRLRSGILLYGPPGCGKTLLASAIASECGLNFISVKGPEL------LNKYIGASEQNVRDLFSRAQSAkpci 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1046903893 288 --FLSRD-LAVENPVKYQGLGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVD 348
Cdd:cd19526    90 lfFDEFDsIAPKRGHDSTGVTDRVVNQLLTQLDGVEGLDGVYVLAATSRPDLIDPALLRPGRLD 153
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 203-350 3.11e-09

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 58.24  E-value: 3.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 203 KDIREFID----NPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGELEHSICLLSLTDSslsddrLNHLLSVAPQQ-- 276
Cdd:PTZ00454  155 QEIREAVElpltCPELYEQIGIDPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEF------VQKYLGEGPRMvr 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 277 -----------SLVLLEDVDAAFLSR-------DLAVEnpvkyqglgRLTFSgLLNALDGVASTEARIVFMTTNHIDRLD 338
Cdd:PTZ00454  229 dvfrlarenapSIIFIDEVDSIATKRfdaqtgaDREVQ---------RILLE-LLNQMDGFDQTTNVKVIMATNRADTLD 298

                         170
                  ....*....|..
gi 1046903893 339 PALIRPGRVDLK 350
Cdd:PTZ00454  299 PALLRPGRLDRK 310
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
188-399 9.96e-09

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 55.66  E-value: 9.96e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 188 LDSVVLQQGLADRIVKDIREF--IDNPKWYidrGIPYRRGYLLYGPPGCGKSSFITALAGELE--------HSIcllSLT 257
Cdd:COG1223     1 LDDVVGQEEAKKKLKLIIKELrrRENLRKF---GLWPPRKILFYGPPGTGKTMLAEALAGELKlplltvrlDSL---IGS 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 258 DSSLSDDRLNHLLSVAPQQSLVLLED-VDAAFLSRDLavENPVKYqgLGRLTfSGLLNALDGVASteaRIVFM-TTNHID 335
Cdd:COG1223    75 YLGETARNLRKLFDFARRAPCVIFFDeFDAIAKDRGD--QNDVGE--VKRVV-NALLQELDGLPS---GSVVIaATNHPE 146

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1046903893 336 RLDPALIRpgRVDLKEYVGYCSHWQLTQMFQRFYPGQAPSLAENFAEHVlKATSQISPAQVQGY 399
Cdd:COG1223   147 LLDSALWR--RFDEVIEFPLPDKEERKEILELNLKKFPLPFELDLKKLA-KKLEGLSGADIEKV 207
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 203-353 1.46e-08

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 56.84  E-value: 1.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 203 KDIREFID----NPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGELEHSICLLSLTDSSL-----SDDRLNHLLSVA 273
Cdd:TIGR01243 463 QELREAVEwplkHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSkwvgeSEKAIREIFRKA 542

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 274 PQQS--LVLLEDVDAAFLSR----DLAVENPVKYQglgrltfsgLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRV 347
Cdd:TIGR01243 543 RQAApaIIFFDEIDAIAPARgarfDTSVTDRIVNQ---------LLTEMDGIQELSNVVVIAATNRPDILDPALLRPGRF 613


                  ....*.
gi 1046903893 348 DLKEYV 353
Cdd:TIGR01243 614 DRLILV 619
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 212-348 2.45e-07

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 50.20  E-value: 2.45e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 212 PKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGELEH------------SICLLSLTDSSLSDDRLNHLLSVAPQQSLV 279
Cdd:cd19517    23 PEVFAKFKITPPRGVLFHGPPGTGKTLMARALAAECSKggqkvsffmrkgADCLSKWVGEAERQLRLLFEEAYRMQPSII 102

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046903893 280 LLEDVDAaflsrdLAVENPVKYQGLGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVD 348
Cdd:cd19517   103 FFDEIDG------LAPVRSSKQEQIHASIVSTLLALMDGLDNRGQVVVIGATNRPDALDPALRRPGRFD 165
ftsH CHL00176
cell division protein; Validated
 208-348 4.85e-07

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 51.97  E-value: 4.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 208 FIDNPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGELE---HSI--CLLSLTDSSLSDDRLNHLLSVAPQQS--LVL 280
Cdd:CHL00176  201 FLKKPERFTAVGAKIPKGVLLVGPPGTGKTLLAKAIAGEAEvpfFSIsgSEFVEMFVGVGAARVRDLFKKAKENSpcIVF 280

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 281 LEDVDAAFLSRDLAVE--NPVKYQglgrlTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVD 348
Cdd:CHL00176  281 IDEIDAVGRQRGAGIGggNDEREQ-----TLNQLLTEMDGFKGNKGVIVIAATNRVDILDAALLRPGRFD 345
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 199-355 5.83e-07

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 48.68  E-value: 5.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 199 DRIVKDIREFIDNPKWyidrgipyrRGYLLYGPPGCGKSSFITALAGELEHSIcllsltdssLSDDRLNHLLSVapqQSL 278
Cdd:cd00009     4 EEAIEALREALELPPP---------KNLLLYGPPGTGKTTLARAIANELFRPG---------APFLYLNASDLL---EGL 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 279 VLLEDVDAAFLSRDLAVENPVKY--------QGLGRLTFSGLLNAL----DGVASTEARIVFMTTNHIDRLDPALIRPGR 346
Cdd:cd00009    63 VVAELFGHFLVRLLFELAEKAKPgvlfideiDSLSRGAQNALLRVLetlnDLRIDRENVRVIGATNRPLLGDLDRALYDR 142


                  ....*....
gi 1046903893 347 VDLKEYVGY 355
Cdd:cd00009   143 LDIRIVIPL 151
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 199-353 9.00e-07

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 48.66  E-value: 9.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 199 DRIVKDIREFIDNPKWYIDrGIPYRRGYLLYGPPGCGKSSFITALAGELEHS---------ICLLSLTDSSLSDDRLNHL 269
Cdd:cd19527     3 KEILDTIQLPLEHPELFSS-GLRKRSGILLYGPPGTGKTLLAKAIATECSLNflsvkgpelINMYIGESEANVREVFQKA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 270 LSVAPqqSLVLLEDVDAAFLSRDlaveNPVKYQGLGRLTFSGLLNALDGVASTEARI-VFMTTNHIDRLDPALIRPGRVD 348
Cdd:cd19527    82 RDAKP--CVIFFDELDSLAPSRG----NSGDSGGVMDRVVSQLLAELDGMSSSGQDVfVIGATNRPDLLDPALLRPGRFD 155


                  ....*
gi 1046903893 349 LKEYV 353
Cdd:cd19527   156 KLLYL 160
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
 219-350 1.64e-06

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 47.87  E-value: 1.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 219 GIPYRRGYLLYGPPGCGKS---------------------SFITALAGELEHSIcllslTDSSLSDDRLNHLLSVAPQQS 277
Cdd:cd19504    31 GCKHVKGILLYGPPGTGKTlmarqigkmlnarepkivngpEILNKYVGESEANI-----RKLFADAEEEQRRLGANSGLH 105

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1046903893 278 LVLLEDVDAAFLSRDLAVENpvkyQGLGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVDLK 350
Cdd:cd19504   106 IIIFDEIDAICKQRGSMAGS----TGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRKDLIDEALLRPGRLEVQ 174
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 152-348 4.46e-06

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 48.29  E-value: 4.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 152 EEARALALQQEEGKTVMYTAVGsewrtfgyprrrrpldsvvlqqGLADRIvKDIREFID----NPKWYIDRGIPYRRGYL 227
Cdd:PRK03992  113 KDPRVQAMEVIESPNVTYEDIG----------------------GLEEQI-REVREAVElplkKPELFEEVGIEPPKGVL 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 228 LYGPPGCGK------------SSFITALAGEL------EHSicllsltdsslsddRLNH-LLSVAPQQ--SLVLLEDVDA 286
Cdd:PRK03992  170 LYGPPGTGKtllakavahetnATFIRVVGSELvqkfigEGA--------------RLVReLFELAREKapSIIFIDEIDA 235

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 287 AFLSR-------DLAVEnpvkyqglgRlTFSGLLNALDGVAST-EARIVfMTTNHIDRLDPALIRPGRVD 348
Cdd:PRK03992  236 IAAKRtdsgtsgDREVQ---------R-TLMQLLAEMDGFDPRgNVKII-AATNRIDILDPAILRPGRFD 294
PRK04195 PRK04195
replication factor C large subunit; Provisional
 186-247 4.86e-06

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 48.38  E-value: 4.86e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1046903893 186 RP--LDSVVLQqglaDRIVKDIREFIDNpkWyiDRGIPyRRGYLLYGPPGCGKSSFITALAGEL 247
Cdd:PRK04195    9 RPktLSDVVGN----EKAKEQLREWIES--W--LKGKP-KKALLLYGPPGVGKTSLAHALANDY 63
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 223-354 5.53e-06

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 45.83  E-value: 5.53e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893  223 RRGYLLYGPPGCGKSSFITALAGEL------------EHSICLLSLTDSSLSDDRLNHLLSVA------------PQQSL 278
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELgppgggviyidgEDILEEVLDQLLLIIVGGKKASGSGElrlrlalalarkLKPDV 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1046903893  279 VLLEDVDAAflsrdlavenpVKYQGLGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPgRVDLKEYVG 354
Cdd:smart00382  82 LILDEITSL-----------LDAEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLL 145
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
202-348 6.73e-06

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 48.11  E-value: 6.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 202 VKDIREFIDNPKWYIDRG--IPyrRGYLLYGPPGCGKssfiT----ALAGElehsicllsltdsslsddrlnhllsvApq 275
Cdd:COG0465   154 LQEIVDFLKDPEKFTRLGakIP--KGVLLVGPPGTGK----TllakAVAGE--------------------------A-- 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 276 qslvlledvDAAFLS------------------RDL------------------AVenpvkyqglGRLTFSGL------- 312
Cdd:COG0465   200 ---------GVPFFSisgsdfvemfvgvgasrvRDLfeqakknapciifideidAV---------GRQRGAGLggghder 261

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1046903893 313 ---LNAL----DGVASTEARIVFMTTNHIDRLDPALIRPGRVD 348
Cdd:COG0465   262 eqtLNQLlvemDGFEGNEGVIVIAATNRPDVLDPALLRPGRFD 304
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 219-348 3.02e-05

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 43.90  E-value: 3.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 219 GIPYRRGYLLYGPPGCGKSSFITALAGE-----LEHSICLLSLTDSSLSDDRLNHLLSVAPQQS--LVLLEDVDAAFLSR 291
Cdd:cd19507    27 GLPTPKGLLLVGIQGTGKSLTAKAIAGVwqlplLRLDMGRLFGGLVGESESRLRQMIQTAEAIApcVLWIDEIEKGFSNA 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1046903893 292 DLAVEnpvkyQGLGRLTFSGLLNALdgvaSTEARIVFM--TTNHIDRLDPALIRPGRVD 348
Cdd:cd19507   107 DSKGD-----SGTSSRVLGTFLTWL----QEKKKPVFVvaTANNVQSLPPELLRKGRFD 156
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 199-343 2.77e-04

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 41.18  E-value: 2.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046903893 199 DRIVKDIREFIDNPKWYID-----RGIPyrRGYLLYGPPGCGKSSFITALAGEL-------EHSICLLSLTDSSLSDDRL 266
Cdd:cd19509     5 DDAKEALKEAVILPSLRPDlfpglRGPP--RGILLYGPPGTGKTLLARAVASESgstffsiSASSLVSKWVGESEKIVRA 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046903893 267 NHLLSVAPQQSLVLLEDVDaAFLSRDLAVEnpvkYQGLGRLTfSGLLNALDGV-ASTEARIVFM-TTNHIDRLDPALIR 343
Cdd:cd19509    83 LFALARELQPSIIFIDEID-SLLSERGSGE----HEASRRVK-TEFLVQMDGVlNKPEDRVLVLgATNRPWELDEAFLR 155
cell_div_CdvC NF041006
cell division protein CdvC;
224-248 5.33e-04

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 42.03  E-value: 5.33e-04
                          10        20
                  ....*....|....*....|....*
gi 1046903893 224 RGYLLYGPPGCGKSSFITALAGELE 248
Cdd:NF041006  135 RGILLYGPPGCGKTMLAAAVANEID 159
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 224-246 3.14e-03

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 38.17  E-value: 3.14e-03
                          10        20
                  ....*....|....*....|...
gi 1046903893 224 RGYLLYGPPGCGKSSFITALAGE 246
Cdd:cd19520    36 KGVLLYGPPGCGKTMLAKATAKE 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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