probable E3 ubiquitin-protein ligase HERC1 isoform X8 [Rattus norvegicus]
Protein Classification
E3 ubiquitin-protein ligase HERC family protein( domain architecture ID 13420669)
E3 ubiquitin-protein ligase HERC (HECT and RCC1 domain) family protein may act as E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates; also contains SPRY and WD40 domains
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||
| HECTc | cd00078 | HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ... |
4488-4856 | 1.08e-123 | ||||||
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains. : Pssm-ID: 238033 [Multi-domain] Cd Length: 352 Bit Score: 395.39 E-value: 1.08e-123
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| SPRY_HERC1 | cd12881 | SPRY domain in HERC1; This SPRY domain is found in the HERC1, a large protein related to ... |
2030-2187 | 1.39e-86 | ||||||
SPRY domain in HERC1; This SPRY domain is found in the HERC1, a large protein related to chromosome condensation regulator RCC1. It is widely expressed in many tissues, playing an important role in intracellular membrane trafficking in the cytoplasm as well as Golgi apparatus. HERC1 also interacts with tuberous sclerosis 2 (TSC2, tuberin), which suppresses cell growth, and results in the destabilization of TSC2. However, the biological function of HERC1 has yet to be defined. : Pssm-ID: 293939 Cd Length: 162 Bit Score: 280.77 E-value: 1.39e-86
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| ATS1 | COG5184 | Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ... |
4014-4350 | 2.83e-79 | ||||||
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; : Pssm-ID: 444065 [Multi-domain] Cd Length: 343 Bit Score: 267.23 E-value: 2.83e-79
|
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| ATS1 | COG5184 | Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ... |
374-703 | 1.46e-77 | ||||||
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; : Pssm-ID: 444065 [Multi-domain] Cd Length: 343 Bit Score: 262.22 E-value: 1.46e-77
|
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| WD40 | COG2319 | WD40 repeat [General function prediction only]; |
3439-3793 | 1.29e-24 | ||||||
WD40 repeat [General function prediction only]; : Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 110.00 E-value: 1.29e-24
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| UBA_HERC1 | cd14401 | UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins; HERC1, ... |
2751-2794 | 1.51e-22 | ||||||
UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins; HERC1, also called HECT domain and RCC1-like domain-containing protein 1, or p532, or p619, is an ubiquitously expressed multi-domain protein involved in ubiquitin-dependent intracellular membrane trafficking through its interaction with vesicle coat proteins such as clathrin and ARF. Moreover, it has been identified as a tuberous sclerosis complex TSC2-interacting protein that may play a role in TSC-mTOR (mammalian target of rapamycin) pathway. In addition to a ubiquitin-association (UBA) domain, HERC1 contains more than one RCC1-like domains (RLDs) and a C-terminal HECT E3 ubiquitin ligase domain. At this point, it may function as both E3 ubiquitin ligases and guanine nucleotide exchange factors (GEFs). : Pssm-ID: 270584 Cd Length: 44 Bit Score: 93.22 E-value: 1.51e-22
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| RCC1 | pfam00415 | Regulator of chromosome condensation (RCC1) repeat; |
683-733 | 4.75e-11 | ||||||
Regulator of chromosome condensation (RCC1) repeat; : Pssm-ID: 395335 [Multi-domain] Cd Length: 50 Bit Score: 60.61 E-value: 4.75e-11
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| Name | Accession | Description | Interval | E-value | ||||||
| HECTc | cd00078 | HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ... |
4488-4856 | 1.08e-123 | ||||||
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains. Pssm-ID: 238033 [Multi-domain] Cd Length: 352 Bit Score: 395.39 E-value: 1.08e-123
|
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| HECTc | smart00119 | Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ... |
4519-4852 | 1.09e-122 | ||||||
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes. Pssm-ID: 214523 Cd Length: 328 Bit Score: 391.60 E-value: 1.09e-122
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| SPRY_HERC1 | cd12881 | SPRY domain in HERC1; This SPRY domain is found in the HERC1, a large protein related to ... |
2030-2187 | 1.39e-86 | ||||||
SPRY domain in HERC1; This SPRY domain is found in the HERC1, a large protein related to chromosome condensation regulator RCC1. It is widely expressed in many tissues, playing an important role in intracellular membrane trafficking in the cytoplasm as well as Golgi apparatus. HERC1 also interacts with tuberous sclerosis 2 (TSC2, tuberin), which suppresses cell growth, and results in the destabilization of TSC2. However, the biological function of HERC1 has yet to be defined. Pssm-ID: 293939 Cd Length: 162 Bit Score: 280.77 E-value: 1.39e-86
|
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| ATS1 | COG5184 | Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ... |
4014-4350 | 2.83e-79 | ||||||
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; Pssm-ID: 444065 [Multi-domain] Cd Length: 343 Bit Score: 267.23 E-value: 2.83e-79
|
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| ATS1 | COG5184 | Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ... |
374-703 | 1.46e-77 | ||||||
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; Pssm-ID: 444065 [Multi-domain] Cd Length: 343 Bit Score: 262.22 E-value: 1.46e-77
|
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| HECT | pfam00632 | HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ... |
4571-4854 | 1.95e-76 | ||||||
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus. Pssm-ID: 459880 Cd Length: 304 Bit Score: 257.54 E-value: 1.95e-76
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| HUL4 | COG5021 | Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]; |
4510-4852 | 6.77e-53 | ||||||
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 227354 [Multi-domain] Cd Length: 872 Bit Score: 203.85 E-value: 6.77e-53
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| SPRY | pfam00622 | SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many ... |
2072-2185 | 1.08e-25 | ||||||
SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many eukaryotic proteins with a wide range of functions. It is a protein-interaction module involved in many important signalling pathways like RNA processing, regulation of histone H3 methylation, innate immunity or embryonic development. It can be divided into 11 subfamilies based on amino acid sequence similarity or the presence of additional protein domains. The greater SPRY family is divided into the SPRY/B30.2 (which contains a PRY extension at the N-terminal) and SPRY-only sub-families which are preceded by a subdomain that is structurally similar to the PRY region. SPRY/B30.2 structures revealed a bent beta-sandwich fold comprised of two beta-sheets. Distant homologs are domains in butyrophilin/ marenostrin/pyrin. Pssm-ID: 459877 Cd Length: 121 Bit Score: 104.73 E-value: 1.08e-25
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| WD40 | COG2319 | WD40 repeat [General function prediction only]; |
3439-3793 | 1.29e-24 | ||||||
WD40 repeat [General function prediction only]; Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 110.00 E-value: 1.29e-24
|
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| WD40 | cd00200 | WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
3439-3790 | 2.96e-24 | ||||||
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment. Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 106.27 E-value: 2.96e-24
|
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| UBA_HERC1 | cd14401 | UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins; HERC1, ... |
2751-2794 | 1.51e-22 | ||||||
UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins; HERC1, also called HECT domain and RCC1-like domain-containing protein 1, or p532, or p619, is an ubiquitously expressed multi-domain protein involved in ubiquitin-dependent intracellular membrane trafficking through its interaction with vesicle coat proteins such as clathrin and ARF. Moreover, it has been identified as a tuberous sclerosis complex TSC2-interacting protein that may play a role in TSC-mTOR (mammalian target of rapamycin) pathway. In addition to a ubiquitin-association (UBA) domain, HERC1 contains more than one RCC1-like domains (RLDs) and a C-terminal HECT E3 ubiquitin ligase domain. At this point, it may function as both E3 ubiquitin ligases and guanine nucleotide exchange factors (GEFs). Pssm-ID: 270584 Cd Length: 44 Bit Score: 93.22 E-value: 1.51e-22
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| SPRY | smart00449 | Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are ... |
2067-2185 | 1.05e-20 | ||||||
Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues. Pssm-ID: 214669 Cd Length: 122 Bit Score: 90.43 E-value: 1.05e-20
|
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| RCC1 | pfam00415 | Regulator of chromosome condensation (RCC1) repeat; |
4115-4164 | 1.14e-14 | ||||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 395335 [Multi-domain] Cd Length: 50 Bit Score: 71.01 E-value: 1.14e-14
|
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| RCC1 | pfam00415 | Regulator of chromosome condensation (RCC1) repeat; |
529-576 | 9.72e-14 | ||||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 395335 [Multi-domain] Cd Length: 50 Bit Score: 68.31 E-value: 9.72e-14
|
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| RCC1 | pfam00415 | Regulator of chromosome condensation (RCC1) repeat; |
683-733 | 4.75e-11 | ||||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 395335 [Multi-domain] Cd Length: 50 Bit Score: 60.61 E-value: 4.75e-11
|
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| WD40 | smart00320 | WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
3439-3471 | 6.91e-05 | ||||||
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain. Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 42.68 E-value: 6.91e-05
|
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| WD40 | pfam00400 | WD domain, G-beta repeat; |
3438-3471 | 4.57e-04 | ||||||
WD domain, G-beta repeat; Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 40.41 E-value: 4.57e-04
|
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| Name | Accession | Description | Interval | E-value | |||||||
| HECTc | cd00078 | HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ... |
4488-4856 | 1.08e-123 | |||||||
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains. Pssm-ID: 238033 [Multi-domain] Cd Length: 352 Bit Score: 395.39 E-value: 1.08e-123
|
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| HECTc | smart00119 | Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ... |
4519-4852 | 1.09e-122 | |||||||
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes. Pssm-ID: 214523 Cd Length: 328 Bit Score: 391.60 E-value: 1.09e-122
|
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| SPRY_HERC1 | cd12881 | SPRY domain in HERC1; This SPRY domain is found in the HERC1, a large protein related to ... |
2030-2187 | 1.39e-86 | |||||||
SPRY domain in HERC1; This SPRY domain is found in the HERC1, a large protein related to chromosome condensation regulator RCC1. It is widely expressed in many tissues, playing an important role in intracellular membrane trafficking in the cytoplasm as well as Golgi apparatus. HERC1 also interacts with tuberous sclerosis 2 (TSC2, tuberin), which suppresses cell growth, and results in the destabilization of TSC2. However, the biological function of HERC1 has yet to be defined. Pssm-ID: 293939 Cd Length: 162 Bit Score: 280.77 E-value: 1.39e-86
|
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| ATS1 | COG5184 | Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ... |
4014-4350 | 2.83e-79 | |||||||
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; Pssm-ID: 444065 [Multi-domain] Cd Length: 343 Bit Score: 267.23 E-value: 2.83e-79
|
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| ATS1 | COG5184 | Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ... |
374-703 | 1.46e-77 | |||||||
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; Pssm-ID: 444065 [Multi-domain] Cd Length: 343 Bit Score: 262.22 E-value: 1.46e-77
|
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| HECT | pfam00632 | HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ... |
4571-4854 | 1.95e-76 | |||||||
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus. Pssm-ID: 459880 Cd Length: 304 Bit Score: 257.54 E-value: 1.95e-76
|
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| ATS1 | COG5184 | Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ... |
4045-4375 | 1.97e-76 | |||||||
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; Pssm-ID: 444065 [Multi-domain] Cd Length: 343 Bit Score: 259.14 E-value: 1.97e-76
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| ATS1 | COG5184 | Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ... |
406-745 | 2.27e-75 | |||||||
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; Pssm-ID: 444065 [Multi-domain] Cd Length: 343 Bit Score: 256.06 E-value: 2.27e-75
|
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| ATS1 | COG5184 | Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ... |
373-649 | 1.85e-64 | |||||||
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; Pssm-ID: 444065 [Multi-domain] Cd Length: 343 Bit Score: 224.47 E-value: 1.85e-64
|
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| ATS1 | COG5184 | Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ... |
373-605 | 1.58e-53 | |||||||
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; Pssm-ID: 444065 [Multi-domain] Cd Length: 343 Bit Score: 192.88 E-value: 1.58e-53
|
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| HUL4 | COG5021 | Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]; |
4510-4852 | 6.77e-53 | |||||||
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 227354 [Multi-domain] Cd Length: 872 Bit Score: 203.85 E-value: 6.77e-53
|
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| ATS1 | COG5184 | Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ... |
4013-4246 | 2.54e-50 | |||||||
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; Pssm-ID: 444065 [Multi-domain] Cd Length: 343 Bit Score: 183.64 E-value: 2.54e-50
|
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| ATS1 | COG5184 | Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ... |
373-555 | 7.63e-35 | |||||||
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; Pssm-ID: 444065 [Multi-domain] Cd Length: 343 Bit Score: 138.57 E-value: 7.63e-35
|
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| SPRY | pfam00622 | SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many ... |
2072-2185 | 1.08e-25 | |||||||
SPRY domain; SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many eukaryotic proteins with a wide range of functions. It is a protein-interaction module involved in many important signalling pathways like RNA processing, regulation of histone H3 methylation, innate immunity or embryonic development. It can be divided into 11 subfamilies based on amino acid sequence similarity or the presence of additional protein domains. The greater SPRY family is divided into the SPRY/B30.2 (which contains a PRY extension at the N-terminal) and SPRY-only sub-families which are preceded by a subdomain that is structurally similar to the PRY region. SPRY/B30.2 structures revealed a bent beta-sandwich fold comprised of two beta-sheets. Distant homologs are domains in butyrophilin/ marenostrin/pyrin. Pssm-ID: 459877 Cd Length: 121 Bit Score: 104.73 E-value: 1.08e-25
|
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| WD40 | COG2319 | WD40 repeat [General function prediction only]; |
3439-3793 | 1.29e-24 | |||||||
WD40 repeat [General function prediction only]; Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 110.00 E-value: 1.29e-24
|
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| WD40 | cd00200 | WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
3439-3790 | 2.96e-24 | |||||||
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment. Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 106.27 E-value: 2.96e-24
|
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| WD40 | COG2319 | WD40 repeat [General function prediction only]; |
3360-3814 | 1.02e-23 | |||||||
WD40 repeat [General function prediction only]; Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 107.30 E-value: 1.02e-23
|
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| UBA_HERC1 | cd14401 | UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins; HERC1, ... |
2751-2794 | 1.51e-22 | |||||||
UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins; HERC1, also called HECT domain and RCC1-like domain-containing protein 1, or p532, or p619, is an ubiquitously expressed multi-domain protein involved in ubiquitin-dependent intracellular membrane trafficking through its interaction with vesicle coat proteins such as clathrin and ARF. Moreover, it has been identified as a tuberous sclerosis complex TSC2-interacting protein that may play a role in TSC-mTOR (mammalian target of rapamycin) pathway. In addition to a ubiquitin-association (UBA) domain, HERC1 contains more than one RCC1-like domains (RLDs) and a C-terminal HECT E3 ubiquitin ligase domain. At this point, it may function as both E3 ubiquitin ligases and guanine nucleotide exchange factors (GEFs). Pssm-ID: 270584 Cd Length: 44 Bit Score: 93.22 E-value: 1.51e-22
|
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| SPRY | smart00449 | Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are ... |
2067-2185 | 1.05e-20 | |||||||
Domain in SPla and the RYanodine Receptor; Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues. Pssm-ID: 214669 Cd Length: 122 Bit Score: 90.43 E-value: 1.05e-20
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| SPRY | cd11709 | SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit ... |
2068-2185 | 2.32e-18 | |||||||
SPRY domain; SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit Ryanodine receptor (hence the name), are homologous to B30.2. SPRY domains have been identified in at least 11 protein families, covering a wide range of functions, including regulation of cytokine signaling (SOCS), RNA metabolism (DDX1 and hnRNP), immunity to retroviruses (TRIM5alpha), intracellular calcium release (ryanodine receptors or RyR) and regulatory and developmental processes (HERC1 and Ash2L). B30.2 also contains residues in the N-terminus that form a distinct PRY domain structure; i.e. B30.2 domain consists of PRY and SPRY subdomains. B30.2 domains comprise the C-terminus of three protein families: BTNs (receptor glycoproteins of immunoglobulin superfamily); several TRIM proteins (composed of RING/B-box/coiled-coil or RBCC core); Stonutoxin (secreted poisonous protein of the stonefish Synanceia horrida). TRIM/RBCC proteins are involved in a variety of processes, including apoptosis, cell cycle regulation, cell growth, senescence, viral response, meiosis, cell differentiation, and vesicular transport. Genes belonging to this family are implicated in several human diseases that vary from cancer to rare genetic syndromes. The PRY-SPRY domain in these TRIM families is suggested to serve as the target binding site. While SPRY domains are evolutionarily ancient, B30.2 domains are a more recent adaptation where the SPRY/PRY combination is a possible component of immune defense. Mutations found in the SPRY-containing proteins have shown to cause Mediterranean fever and Opitz syndrome. Pssm-ID: 293931 Cd Length: 118 Bit Score: 83.63 E-value: 2.32e-18
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| RCC1 | pfam00415 | Regulator of chromosome condensation (RCC1) repeat; |
4115-4164 | 1.14e-14 | |||||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 395335 [Multi-domain] Cd Length: 50 Bit Score: 71.01 E-value: 1.14e-14
|
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| RCC1 | pfam00415 | Regulator of chromosome condensation (RCC1) repeat; |
4167-4216 | 5.05e-14 | |||||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 395335 [Multi-domain] Cd Length: 50 Bit Score: 69.08 E-value: 5.05e-14
|
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| RCC1 | pfam00415 | Regulator of chromosome condensation (RCC1) repeat; |
4325-4373 | 7.92e-14 | |||||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 395335 [Multi-domain] Cd Length: 50 Bit Score: 68.31 E-value: 7.92e-14
|
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| RCC1 | pfam00415 | Regulator of chromosome condensation (RCC1) repeat; |
529-576 | 9.72e-14 | |||||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 395335 [Multi-domain] Cd Length: 50 Bit Score: 68.31 E-value: 9.72e-14
|
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| RCC1 | pfam00415 | Regulator of chromosome condensation (RCC1) repeat; |
476-526 | 8.41e-13 | |||||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 395335 [Multi-domain] Cd Length: 50 Bit Score: 65.62 E-value: 8.41e-13
|
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| UBA_HERC1_2 | cd14331 | UBA domain found in probable E3 ubiquitin-protein ligase HERC1, HERC2 and similar proteins; ... |
2752-2793 | 5.25e-12 | |||||||
UBA domain found in probable E3 ubiquitin-protein ligase HERC1, HERC2 and similar proteins; HERC1, also called HECT domain and RCC1-like domain-containing protein 1, p532, or p619, is an ubiquitously expressed giant protein involved in ubiquitin-dependent intracellular membrane trafficking through its interaction with vesicle coat proteins such as clathrin and ARF. Moreover, it has been identified as a tuberous sclerosis complex TSC2-interacting protein that may play a role in TSC-mTOR (mammalian target of rapamycin) pathway. HERC2, also called HECT domain and RCC1-like domain-containing protein 2, is a SUMO-regulated E3 ubiquitin ligase that plays an important role in the SUMO-dependent pathway which orchestrates the DNA double-strand break (DSB) response. Moreover, HERC2 functions as a RNF8 auxiliary factor that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. HERC1 and HERC2 are multi-domain proteins with different domain organizations. Both of them contain a ubiquitin-association (UBA) domain, more than one RCC1-like domains (RLDs) and a C-terminal HECT E3 ubiquitin ligase domain. Pssm-ID: 270516 Cd Length: 40 Bit Score: 63.21 E-value: 5.25e-12
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| SPRY_RanBP_like | cd12885 | SPRY domain in Ran binding proteins, SSH4, HECT E3 and SPRYD3; This family includes SPRY ... |
2079-2184 | 7.38e-12 | |||||||
SPRY domain in Ran binding proteins, SSH4, HECT E3 and SPRYD3; This family includes SPRY domains found in Ran binding proteins (RBP or RanBPM) 9 and 10, SSH4 (suppressor of SHR3 null mutation protein 4), SPRY domain-containing protein 3 (SPRYD3) as well as HECT, a C-terminal catalytic domain of a subclass of ubiquitin-protein ligase (E3). RanBP9 and RanBP10 act as androgen receptor (AR) coactivators. Both consist of the N-terminal proline- and glutamine-rich regions, the SPRY domain, and LisH-CTLH and CRA motifs. The SPRY domain in SSH4 may be involved in cargo recognition, either directly or by combination with other adaptors, possibly leading to a higher selectivity. SPRYD3 is highly expressed in most tissues in humans, possibly involved in important cellular processes. HECT E3 mediates the direct transfer of ubiquitin from E2 to substrate. Pssm-ID: 293943 Cd Length: 132 Bit Score: 65.76 E-value: 7.38e-12
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| RCC1 | pfam00415 | Regulator of chromosome condensation (RCC1) repeat; |
4219-4269 | 4.71e-11 | |||||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 395335 [Multi-domain] Cd Length: 50 Bit Score: 60.61 E-value: 4.71e-11
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| RCC1 | pfam00415 | Regulator of chromosome condensation (RCC1) repeat; |
683-733 | 4.75e-11 | |||||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 395335 [Multi-domain] Cd Length: 50 Bit Score: 60.61 E-value: 4.75e-11
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| RCC1 | pfam00415 | Regulator of chromosome condensation (RCC1) repeat; |
579-629 | 2.23e-10 | |||||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 395335 [Multi-domain] Cd Length: 50 Bit Score: 58.68 E-value: 2.23e-10
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| RCC1_2 | pfam13540 | Regulator of chromosome condensation (RCC1) repeat; |
4308-4337 | 1.86e-08 | |||||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 463914 [Multi-domain] Cd Length: 30 Bit Score: 52.81 E-value: 1.86e-08
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| RCC1 | pfam00415 | Regulator of chromosome condensation (RCC1) repeat; |
633-680 | 4.06e-07 | |||||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 395335 [Multi-domain] Cd Length: 50 Bit Score: 49.44 E-value: 4.06e-07
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| SPRY_RanBP9_10 | cd12909 | SPRY domain in Ran binding proteins 9 and 10; This family includes SPRY domain in Ran binding ... |
2129-2183 | 4.98e-07 | |||||||
SPRY domain in Ran binding proteins 9 and 10; This family includes SPRY domain in Ran binding protein (RBP or RanBPM) 9 and 10, and similar proteins. RanBP9 (also known as RanBPM), a binding partner of Ran, is a small Ras-like GTPase that exerts multiple functions via interactions with various proteins. RanBP9 and RanBP10 also act as androgen receptor (AR) coactivators. Both consist of the N-terminal proline- and glutamine-rich regions, the SPRY domain, and LisH-CTLH and CRA motifs. SPRY domain of RanBPM forms a complex with CD39, a prototypic member of the NTPDase family, thus down-regulating activity substantially. RanBP10 enhances the transcriptional activity of AR in a ligand-dependent manner and exhibits a protein expression pattern different from RanBPM in various cell lines. RanBP10 is highly expressed in AR-positive prostate cancer LNCaP cells, while RanBPM is abundant in WI-38 and MCF-7 cells. Pssm-ID: 293966 Cd Length: 144 Bit Score: 52.14 E-value: 4.98e-07
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| RCC1_2 | pfam13540 | Regulator of chromosome condensation (RCC1) repeat; |
667-696 | 5.60e-07 | |||||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 463914 [Multi-domain] Cd Length: 30 Bit Score: 48.57 E-value: 5.60e-07
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| RCC1_2 | pfam13540 | Regulator of chromosome condensation (RCC1) repeat; |
513-542 | 6.49e-07 | |||||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 463914 [Multi-domain] Cd Length: 30 Bit Score: 48.19 E-value: 6.49e-07
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| SPRY_Ash2 | cd12872 | SPRY domain in Ash2; This SPRY domain is found at the C-terminus of Ash2 (absent, small, or ... |
2053-2174 | 8.66e-07 | |||||||
SPRY domain in Ash2; This SPRY domain is found at the C-terminus of Ash2 (absent, small, or homeotic discs 2) -like proteins, core components of all mixed-lineage leukemia (MLL) family histone methyltransferases. Ash2 is a member of the trithorax group of transcriptional regulators of the Hox genes. Recent studies show that the SPRY domain of Ash2 mediates the interaction with RbBP5 and has an important role in regulating the methyltransferase activity of MLL complexes. In yeast, Ash2 is involved in histone methylation and is required for the earliest stages of embryogenesis. Pssm-ID: 293932 Cd Length: 150 Bit Score: 51.75 E-value: 8.66e-07
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| SPRY_SOCS_Fbox | cd12875 | SPRY domain in Fbxo45 and suppressors of cytokine signaling (SOCS) proteins; This family ... |
2063-2171 | 1.07e-06 | |||||||
SPRY domain in Fbxo45 and suppressors of cytokine signaling (SOCS) proteins; This family consists of the SPRY domain-containing SOCS box protein family (SPSB1-4, also known as SSB-1 to -4) as well as F-box protein 45 (Fbxo45), a novel synaptic E3 and ubiquitin ligase. The SPSB protein is composed of a central SPRY protein interaction domain and a C-terminal SOCS box. SPSB1, SPSB2, and SPSB4 interact with prostate apoptosis response protein 4 (Par-4) and are negative regulators that recruit the ECS E3 ubiquitin ligase complex to polyubiquitinate inducible nitric-oxide synthase (iNOS), resulting in its proteasomal degradation. Fbxo45 is related to this family; it is located N-terminal to the SPRY domain, and known to induce the degradation of a synaptic vesicle-priming factor, Munc13-1, via the SPRY domain, thus playing an important role in the regulation of neurotransmission by modulating Munc13-1 at the synapse. Suppressor of cytokine signaling (SOCS) proteins negatively regulate signaling from JAK-associated cytokine receptor complexes, and play key roles in the regulation of immune homeostasis. Pssm-ID: 293935 Cd Length: 169 Bit Score: 51.69 E-value: 1.07e-06
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| RCC1 | pfam00415 | Regulator of chromosome condensation (RCC1) repeat; |
4060-4112 | 1.56e-06 | |||||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 395335 [Multi-domain] Cd Length: 50 Bit Score: 47.90 E-value: 1.56e-06
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| RCC1 | pfam00415 | Regulator of chromosome condensation (RCC1) repeat; |
421-472 | 3.69e-06 | |||||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 395335 [Multi-domain] Cd Length: 50 Bit Score: 46.74 E-value: 3.69e-06
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| RCC1_2 | pfam13540 | Regulator of chromosome condensation (RCC1) repeat; |
4151-4180 | 5.28e-06 | |||||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 463914 [Multi-domain] Cd Length: 30 Bit Score: 45.88 E-value: 5.28e-06
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| RCC1 | pfam00415 | Regulator of chromosome condensation (RCC1) repeat; |
4272-4321 | 8.49e-06 | |||||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 395335 [Multi-domain] Cd Length: 50 Bit Score: 45.59 E-value: 8.49e-06
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| WD40 | cd00200 | WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
3430-3528 | 1.40e-05 | |||||||
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment. Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 50.41 E-value: 1.40e-05
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| RCC1_2 | pfam13540 | Regulator of chromosome condensation (RCC1) repeat; |
4102-4127 | 5.88e-05 | |||||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 463914 [Multi-domain] Cd Length: 30 Bit Score: 42.80 E-value: 5.88e-05
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| WD40 | smart00320 | WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
3439-3471 | 6.91e-05 | |||||||
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain. Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 42.68 E-value: 6.91e-05
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| SPRY_hnRNP | cd12884 | SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1; This domain, ... |
2111-2173 | 9.72e-05 | |||||||
SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1; This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C-terminus of heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1 (also known as HNRPUL1 ) which is a major constituent of nuclear matrix or scaffold and binds directly to DNA sequences through the N-terminal acidic region named serum amyloid P (SAP). Its function is specifically modulated by E1B-55kDa in adenovirus-infected cells. HNRPUL1 also participates in ATR protein kinase signaling pathways during adenovirus infection. Two transcript variants encoding different isoforms have been found for this gene. When associated with bromodomain-containing protein 7 (BRD7), it activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Pssm-ID: 293942 Cd Length: 177 Bit Score: 46.43 E-value: 9.72e-05
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| RCC1_2 | pfam13540 | Regulator of chromosome condensation (RCC1) repeat; |
4205-4232 | 1.10e-04 | |||||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 463914 [Multi-domain] Cd Length: 30 Bit Score: 42.03 E-value: 1.10e-04
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| RCC1_2 | pfam13540 | Regulator of chromosome condensation (RCC1) repeat; |
616-643 | 1.17e-04 | |||||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 463914 [Multi-domain] Cd Length: 30 Bit Score: 42.03 E-value: 1.17e-04
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| RCC1_2 | pfam13540 | Regulator of chromosome condensation (RCC1) repeat; |
4256-4281 | 1.84e-04 | |||||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 463914 [Multi-domain] Cd Length: 30 Bit Score: 41.26 E-value: 1.84e-04
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| RCC1_2 | pfam13540 | Regulator of chromosome condensation (RCC1) repeat; |
566-592 | 3.03e-04 | |||||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 463914 [Multi-domain] Cd Length: 30 Bit Score: 40.87 E-value: 3.03e-04
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| WD40 | smart00320 | WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
3753-3790 | 3.17e-04 | |||||||
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain. Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 41.14 E-value: 3.17e-04
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| WD40 | pfam00400 | WD domain, G-beta repeat; |
3438-3471 | 4.57e-04 | |||||||
WD domain, G-beta repeat; Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 40.41 E-value: 4.57e-04
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| SPRY_like | cd12886 | SPRY domain-like in bacteria; This family contains SPRY-like domains that are found only in ... |
2073-2180 | 4.66e-04 | |||||||
SPRY domain-like in bacteria; This family contains SPRY-like domains that are found only in bacterial and are mostly uncharacterized. SPRY domains, first identified in the SP1A kinase of Dictyostelium and rabbit Ryanodine receptor (hence the name), are homologous to B30.2. SPRY domains have been identified in at least 11 eukaryotic protein families, covering a wide range of functions, including regulation of cytokine signaling (SOCS), RNA metabolism (DDX1 and hnRNP), immunity to retroviruses (TRIM5alpha), intracellular calcium release (ryanodine receptors or RyR) and regulatory and developmental processes (HERC1 and Ash2L). Pssm-ID: 293944 Cd Length: 129 Bit Score: 43.26 E-value: 4.66e-04
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| SPRY_DDX1 | cd12873 | SPRY domain associated with DEAD box gene DDX1; This SPRY domain is associated with the DEAD ... |
2128-2171 | 5.65e-04 | |||||||
SPRY domain associated with DEAD box gene DDX1; This SPRY domain is associated with the DEAD box gene, DDX1, an RNA-dependent ATPase involved in HIV-1 Rev function and virus replication. It is suggested that DDX1 acts as a cellular cofactor by promoting oligomerization of Rev on the Rev response element (RRE). DDX1 RNA is overexpressed in breast cancer, data showing a strong and independent association between poor prognosis and deregulation of the DEAD box protein DDX1, thus potentially serving as an effective prognostic biomarker for early recurrence in primary breast cancer. DDX1 also interacts with RelA and enhances nuclear factor kappaB-mediated transcription. DEAD-box proteins are associated with all levels of RNA metabolism and function, and have been implicated in translation initiation, transcription, RNA splicing, ribosome assembly, RNA transport, and RNA decay. Pssm-ID: 293933 Cd Length: 155 Bit Score: 43.72 E-value: 5.65e-04
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| RCC1_2 | pfam13540 | Regulator of chromosome condensation (RCC1) repeat; |
457-488 | 6.97e-04 | |||||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 463914 [Multi-domain] Cd Length: 30 Bit Score: 39.71 E-value: 6.97e-04
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| WD40 | cd00200 | WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
3754-3814 | 8.36e-04 | |||||||
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment. Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 45.02 E-value: 8.36e-04
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| WD40 | pfam00400 | WD domain, G-beta repeat; |
3753-3790 | 8.50e-04 | |||||||
WD domain, G-beta repeat; Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 39.64 E-value: 8.50e-04
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| SPRY2_RyR | cd12878 | SPRY domain 2 (SPRY2) of ryanodine receptor (RyR); This SPRY domain (SPRY2) is the second of ... |
2107-2184 | 9.06e-04 | |||||||
SPRY domain 2 (SPRY2) of ryanodine receptor (RyR); This SPRY domain (SPRY2) is the second of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR). There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs, The SPRY2 domain has been shown to bind to the dihydropryidine receptor (DHPR) II-III loop and the ASI region of RyR1 Pssm-ID: 240458 Cd Length: 133 Bit Score: 42.29 E-value: 9.06e-04
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| RCC1 | pfam00415 | Regulator of chromosome condensation (RCC1) repeat; |
373-418 | 9.50e-03 | |||||||
Regulator of chromosome condensation (RCC1) repeat; Pssm-ID: 395335 [Multi-domain] Cd Length: 50 Bit Score: 37.11 E-value: 9.50e-03
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