thyroid adenoma-associated protein (THADA)/TRM732 family protein is a DUF2428 domain-containing protein; similar to Homo sapiens thyroid adenoma-associated protein (THADA) and the tRNA -methyltransferase non-catalytic subunit TRM732
THADA/TRM732, DUF2428; This conserved domain is found in Thyroid adenoma-associated proteins ...
938-1239
1.90e-83
THADA/TRM732, DUF2428; This conserved domain is found in Thyroid adenoma-associated proteins (THADA) and the yeast homolog, TRM732. Trm732 forms a complex with the methyltransferase Trm7 to 2'- O-methylate tRNA residue 32 (Nm32), being required for Trm7 methylation activity. In humans, mutations of the Trm7 homolog FTSJ1, which interacts with THADA, impair Nm32 modifications, associated with non-syndromic X-linked intellectual disability. It has been suggested that these proteins may play a role in additional biological processes not related to translation. This domain contains a RRSAGLP conserved motif that is required for tRNA modification activity (Funk HM et.al., Preprint from bioRxiv, 03 Jun 2021 DOI: 10.1101/2021.06.03.446962).
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Pssm-ID: 463054 [Multi-domain] Cd Length: 260 Bit Score: 274.62 E-value: 1.90e-83
THADA/TRM732, DUF2428; This conserved domain is found in Thyroid adenoma-associated proteins ...
938-1239
1.90e-83
THADA/TRM732, DUF2428; This conserved domain is found in Thyroid adenoma-associated proteins (THADA) and the yeast homolog, TRM732. Trm732 forms a complex with the methyltransferase Trm7 to 2'- O-methylate tRNA residue 32 (Nm32), being required for Trm7 methylation activity. In humans, mutations of the Trm7 homolog FTSJ1, which interacts with THADA, impair Nm32 modifications, associated with non-syndromic X-linked intellectual disability. It has been suggested that these proteins may play a role in additional biological processes not related to translation. This domain contains a RRSAGLP conserved motif that is required for tRNA modification activity (Funk HM et.al., Preprint from bioRxiv, 03 Jun 2021 DOI: 10.1101/2021.06.03.446962).
Pssm-ID: 463054 [Multi-domain] Cd Length: 260 Bit Score: 274.62 E-value: 1.90e-83
THADA/TRM732, DUF2428; This conserved domain is found in Thyroid adenoma-associated proteins ...
938-1239
1.90e-83
THADA/TRM732, DUF2428; This conserved domain is found in Thyroid adenoma-associated proteins (THADA) and the yeast homolog, TRM732. Trm732 forms a complex with the methyltransferase Trm7 to 2'- O-methylate tRNA residue 32 (Nm32), being required for Trm7 methylation activity. In humans, mutations of the Trm7 homolog FTSJ1, which interacts with THADA, impair Nm32 modifications, associated with non-syndromic X-linked intellectual disability. It has been suggested that these proteins may play a role in additional biological processes not related to translation. This domain contains a RRSAGLP conserved motif that is required for tRNA modification activity (Funk HM et.al., Preprint from bioRxiv, 03 Jun 2021 DOI: 10.1101/2021.06.03.446962).
Pssm-ID: 463054 [Multi-domain] Cd Length: 260 Bit Score: 274.62 E-value: 1.90e-83
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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