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Conserved domains on  [gi|1046888501|ref|XP_017448886|]
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transcription factor HIVEP3 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
207-231 4.14e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.05  E-value: 4.14e-06
                           10        20
                   ....*....|....*....|....*
gi 1046888501  207 LQKHIRSHTGERPYPCGPCGFSFKT 231
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 1943-2320 6.77e-06

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 51.71  E-value: 6.77e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 1943 SRPSLTRKHSLTKTDSSPQRCSPARAQASVASTPGPQTGPGRDLSPHLCGSPRPElsclTPYPIGR-EVPAGLESATVTG 2021
Cdd:PHA03307    58 GAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPS----SPDPPPPtPPPASPPPSPAPD 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 2022 TPRCSPTRRRSLGRAESSPPHTVLPGTWALGGPCSPSVDkyGLGLGPVPRALLQPVPLPHTLLSRSPETCASAWKTESRS 2101
Cdd:PHA03307   134 LSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQA--ALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSS 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 2102 PSAGPAPlSSRPSSAPHDFHGhlPSRSEENLFSHLPLHSQHLNRTPCPLIPIGGIQMVQARPGAHPTLLSGPCAAWVSGF 2181
Cdd:PHA03307   212 PISASAS-SPAPAPGRSAADD--AGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSS 288

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 2182 SGGGSDltGAREAQERSRWSPTESPSASVSPVAKVSKFTLSSELEEERTSRGPGRPPAWEPHRAEAPAETMG-THSPCPP 2260
Cdd:PHA03307   289 SSPRER--SPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPpADPSSPR 366

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1046888501 2261 QLPQGHPLAPSWR-----------GLLESPHALANLKASSFPPLDRSSSMDCLAETSTCFPPRSRNL--SGEP 2320
Cdd:PHA03307   367 KRPRPSRAPSSPAasagrptrrraRAAVAGRARRRDATGRFPAGRPRPSPLDAGAASGAFYARYPLLtpSGEP 439
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1736-1761 2.17e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 2.17e-05
                           10        20
                   ....*....|....*....|....*.
gi 1046888501 1736 MLKKHIRTHTDVRPYVCRHCHFAFKT 1761
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1722-1744 1.64e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 40.36  E-value: 1.64e-04
                           10        20
                   ....*....|....*....|...
gi 1046888501 1722 YVCEECGIRCKKPSMLKKHIRTH 1744
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 1035-1274 8.73e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 8.73e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 1035 QASLSRPPEAELEATPKGKQESSEEPSASKPSTKSSMAQISVATIQGGLSGSKSQMQDRPPLGSSPPytealQVFQPLGT 1114
Cdd:PHA03247  2780 PRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPP-----PPSLPLGG 2854

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 1115 QLPPPVSLFSLQQLLPQEQEQSSeffPTQAMAGLLSSPySVPPLPPSLFQAPPLPLQPTVLHPSQLHLPQLLPHAADIPF 1194
Cdd:PHA03247  2855 SVAPGGDVRRRPPSRSPAAKPAA---PARPPVRRLARP-AVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQ 2930

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 1195 QQPPS-FLPMPCPAPST-LSGYFLPLQSQFALQLPGEIESHLPSIKTSLPPLATGPPGPSSSTEYSSDIQLPPVTPQATS 1272
Cdd:PHA03247  2931 PPPPPpPRPQPPLAPTTdPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASS 3010


                   ..
gi 1046888501 1273 PA 1274
Cdd:PHA03247  3011 LA 3012
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
207-231 4.14e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.05  E-value: 4.14e-06
                           10        20
                   ....*....|....*....|....*
gi 1046888501  207 LQKHIRSHTGERPYPCGPCGFSFKT 231
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1943-2320 6.77e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 51.71  E-value: 6.77e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 1943 SRPSLTRKHSLTKTDSSPQRCSPARAQASVASTPGPQTGPGRDLSPHLCGSPRPElsclTPYPIGR-EVPAGLESATVTG 2021
Cdd:PHA03307    58 GAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPS----SPDPPPPtPPPASPPPSPAPD 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 2022 TPRCSPTRRRSLGRAESSPPHTVLPGTWALGGPCSPSVDkyGLGLGPVPRALLQPVPLPHTLLSRSPETCASAWKTESRS 2101
Cdd:PHA03307   134 LSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQA--ALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSS 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 2102 PSAGPAPlSSRPSSAPHDFHGhlPSRSEENLFSHLPLHSQHLNRTPCPLIPIGGIQMVQARPGAHPTLLSGPCAAWVSGF 2181
Cdd:PHA03307   212 PISASAS-SPAPAPGRSAADD--AGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSS 288

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 2182 SGGGSDltGAREAQERSRWSPTESPSASVSPVAKVSKFTLSSELEEERTSRGPGRPPAWEPHRAEAPAETMG-THSPCPP 2260
Cdd:PHA03307   289 SSPRER--SPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPpADPSSPR 366

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1046888501 2261 QLPQGHPLAPSWR-----------GLLESPHALANLKASSFPPLDRSSSMDCLAETSTCFPPRSRNL--SGEP 2320
Cdd:PHA03307   367 KRPRPSRAPSSPAasagrptrrraRAAVAGRARRRDATGRFPAGRPRPSPLDAGAASGAFYARYPLLtpSGEP 439
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1736-1761 2.17e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 2.17e-05
                           10        20
                   ....*....|....*....|....*.
gi 1046888501 1736 MLKKHIRTHTDVRPYVCRHCHFAFKT 1761
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1722-1744 1.64e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 40.36  E-value: 1.64e-04
                           10        20
                   ....*....|....*....|...
gi 1046888501 1722 YVCEECGIRCKKPSMLKKHIRTH 1744
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1035-1274 8.73e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 8.73e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 1035 QASLSRPPEAELEATPKGKQESSEEPSASKPSTKSSMAQISVATIQGGLSGSKSQMQDRPPLGSSPPytealQVFQPLGT 1114
Cdd:PHA03247  2780 PRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPP-----PPSLPLGG 2854

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 1115 QLPPPVSLFSLQQLLPQEQEQSSeffPTQAMAGLLSSPySVPPLPPSLFQAPPLPLQPTVLHPSQLHLPQLLPHAADIPF 1194
Cdd:PHA03247  2855 SVAPGGDVRRRPPSRSPAAKPAA---PARPPVRRLARP-AVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQ 2930

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 1195 QQPPS-FLPMPCPAPST-LSGYFLPLQSQFALQLPGEIESHLPSIKTSLPPLATGPPGPSSSTEYSSDIQLPPVTPQATS 1272
Cdd:PHA03247  2931 PPPPPpPRPQPPLAPTTdPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASS 3010


                   ..
gi 1046888501 1273 PA 1274
Cdd:PHA03247  3011 LA 3012
ZnF_C2H2 smart00355
zinc finger;
1722-1744 6.79e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.90  E-value: 6.79e-03
                            10        20
                    ....*....|....*....|...
gi 1046888501  1722 YVCEECGIRCKKPSMLKKHIRTH 1744
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
207-231 4.14e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.05  E-value: 4.14e-06
                           10        20
                   ....*....|....*....|....*
gi 1046888501  207 LQKHIRSHTGERPYPCGPCGFSFKT 231
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1943-2320 6.77e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 51.71  E-value: 6.77e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 1943 SRPSLTRKHSLTKTDSSPQRCSPARAQASVASTPGPQTGPGRDLSPHLCGSPRPElsclTPYPIGR-EVPAGLESATVTG 2021
Cdd:PHA03307    58 GAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPS----SPDPPPPtPPPASPPPSPAPD 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 2022 TPRCSPTRRRSLGRAESSPPHTVLPGTWALGGPCSPSVDkyGLGLGPVPRALLQPVPLPHTLLSRSPETCASAWKTESRS 2101
Cdd:PHA03307   134 LSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQA--ALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSS 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 2102 PSAGPAPlSSRPSSAPHDFHGhlPSRSEENLFSHLPLHSQHLNRTPCPLIPIGGIQMVQARPGAHPTLLSGPCAAWVSGF 2181
Cdd:PHA03307   212 PISASAS-SPAPAPGRSAADD--AGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSS 288

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 2182 SGGGSDltGAREAQERSRWSPTESPSASVSPVAKVSKFTLSSELEEERTSRGPGRPPAWEPHRAEAPAETMG-THSPCPP 2260
Cdd:PHA03307   289 SSPRER--SPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPpADPSSPR 366

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1046888501 2261 QLPQGHPLAPSWR-----------GLLESPHALANLKASSFPPLDRSSSMDCLAETSTCFPPRSRNL--SGEP 2320
Cdd:PHA03307   367 KRPRPSRAPSSPAasagrptrrraRAAVAGRARRRDATGRFPAGRPRPSPLDAGAASGAFYARYPLLtpSGEP 439
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1736-1761 2.17e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 2.17e-05
                           10        20
                   ....*....|....*....|....*.
gi 1046888501 1736 MLKKHIRTHTDVRPYVCRHCHFAFKT 1761
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1722-1744 1.64e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 40.36  E-value: 1.64e-04
                           10        20
                   ....*....|....*....|...
gi 1046888501 1722 YVCEECGIRCKKPSMLKKHIRTH 1744
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1871-2271 2.70e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 2.70e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 1871 PQPPDA----------TSDAAPRGSSISEATRLTASScSTPSQGTQGLPRLGLAPLEKGTSSALSPKATSPRRPWSPSKE 1940
Cdd:PHA03247  2554 PLPPAAppaapdrsvpPPRPAPRPSEPAVTSRARRPD-APPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPS 2632

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 1941 A------GSRPSLTRKHSLTKTDSSPQRCSP---ARAQASVASTPGPQTGPGRDLSPHLCGS----PRPELSCLTPYPIG 2007
Cdd:PHA03247  2633 PaanepdPHPPPTVPPPERPRDDPAPGRVSRprrARRLGRAAQASSPPQRPRRRAARPTVGSltslADPPPPPPTPEPAP 2712

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 2008 REVPAGLESATVTGTPRCSPTRRRSLGRAESSPPHTVLPGTWA-LGGPCSPSvdkyglglGPvprallqPVPLPHTLLSR 2086
Cdd:PHA03247  2713 HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPArPARPPTTA--------GP-------PAPAPPAAPAA 2777

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 2087 SPETCASAWKTESRSPSAGPAPLSSRPSSAPHDFHGhlpsrseenlfshlPLHSQHLNRTPCPLIPiggiqmvqARPGAH 2166
Cdd:PHA03247  2778 GPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLA--------------PAAALPPAASPAGPLP--------PPTSAQ 2835

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 2167 PTLLSGPCAAWVSGFSGGGSDLTGAREAQERSRWSPTESPSASVSPVAK------VSKFTLSSELEEERTSRGPgRPPAW 2240
Cdd:PHA03247  2836 PTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRrlarpaVSRSTESFALPPDQPERPP-QPQAP 2914

                          410       420       430
                   ....*....|....*....|....*....|..
gi 1046888501 2241 EPHRAEAPAETMGTHSPCPPQLPQGH-PLAPS 2271
Cdd:PHA03247  2915 PPPQPQPQPPPPPQPQPPPPPPPRPQpPLAPT 2946
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1901-2138 4.01e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 45.64  E-value: 4.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 1901 PSQ--GTQGLPRLGLAPLEKGTSSALSPKATSPRRPWSPSKEAGSRPSLTRKHSLTktdSSPQRCSPARAQASVASTPGP 1978
Cdd:PRK12323   365 PGQsgGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVA---AAPARRSPAPEALAAARQASA 441

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 1979 QTGPGRDLSPhlcgsPRPelsclTPYPIGREVPAGLESATVTGTPRCSPTRRRSLGRA----ESSPPHTVLPGTWALGGP 2054
Cdd:PRK12323   442 RGPGGAPAPA-----PAP-----AAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPapadDDPPPWEELPPEFASPAP 511

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 2055 CSPSVDKYGLGLGPVPRALLQPVPLPHTLLSRSPETCASAWKTESRSPSAGPAPLSSRPSSAPHDFHGHLPSrseenLFS 2134
Cdd:PRK12323   512 AQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPA-----LAA 586


                   ....
gi 1046888501 2135 HLPL 2138
Cdd:PRK12323   587 RLPV 590
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1035-1274 8.73e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 8.73e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 1035 QASLSRPPEAELEATPKGKQESSEEPSASKPSTKSSMAQISVATIQGGLSGSKSQMQDRPPLGSSPPytealQVFQPLGT 1114
Cdd:PHA03247  2780 PRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPP-----PPSLPLGG 2854

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 1115 QLPPPVSLFSLQQLLPQEQEQSSeffPTQAMAGLLSSPySVPPLPPSLFQAPPLPLQPTVLHPSQLHLPQLLPHAADIPF 1194
Cdd:PHA03247  2855 SVAPGGDVRRRPPSRSPAAKPAA---PARPPVRRLARP-AVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQ 2930

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 1195 QQPPS-FLPMPCPAPST-LSGYFLPLQSQFALQLPGEIESHLPSIKTSLPPLATGPPGPSSSTEYSSDIQLPPVTPQATS 1272
Cdd:PHA03247  2931 PPPPPpPRPQPPLAPTTdPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASS 3010


                   ..
gi 1046888501 1273 PA 1274
Cdd:PHA03247  3011 LA 3012
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 1750-1771 1.66e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 1.66e-03
                           10        20
                   ....*....|....*....|..
gi 1046888501 1750 YVCRHCHFAFKTKGNLTKHMKS 1771
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRT 22
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1978-2327 3.98e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 3.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 1978 PQTGPGRDLSPHLCgSPRPELSCLTPYPIGREVPAGLESATVTGTPRCSPtrrRSLGRAESSPPHTVLPGTWALGGPCSP 2057
Cdd:PHA03247  2560 PPAAPDRSVPPPRP-APRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDP---RGPAPPSPLPPDTHAPDPPPPSPSPAA 2635

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 2058 SVDKYGLGLGPVPRALLQPVPLPHTLlSRSPETCASAWKTESRSPSAGPAPLSSRPSSAP--HDFHGHLPSRSEEnlfsh 2135
Cdd:PHA03247  2636 NEPDPHPPPTVPPPERPRDDPAPGRV-SRPRRARRLGRAAQASSPPQRPRRRAARPTVGSltSLADPPPPPPTPE----- 2709

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 2136 lPLHSQHLNRTPCPLIPIGGIQMVQARPGAHPTLLSGPCAAWVSGFSGGGSDLTGAREAQERSRWSPTESPSASVSPVAK 2215
Cdd:PHA03247  2710 -PAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAV 2788

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 2216 VSkftLSSELEEERTSRGPGRPPAWEPHRAEAPAETMGTHSPCPPQlPQGHPLAPSW-RGLLESPHALANLKASSFPPLD 2294
Cdd:PHA03247  2789 AS---LSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPP-TSAQPTAPPPpPGPPPPSLPLGGSVAPGGDVRR 2864

                          330       340       350
                   ....*....|....*....|....*....|...
gi 1046888501 2295 RSSSMDCLAETSTCFPPRSRNLSGEPRTRPDSP 2327
Cdd:PHA03247  2865 RPPSRSPAAKPAAPARPPVRRLARPAVSRSTES 2897
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1871-2232 4.37e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 4.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 1871 PQPPDATSDAAPRGSSISEATRLTASSCSTPSQGTQGLPRLGLAPLEKGTSSALS------PKATSPRRPWSPSKEAGSR 1944
Cdd:PHA03247  2645 TVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLAdpppppPTPEPAPHALVSATPLPPG 2724

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 1945 PSLTRKHSL--------------TKTDSSPQR-CSPARAQASVASTP--GPQTGPGRDLSPHLCGSPRPELSCLTPYPIG 2007
Cdd:PHA03247  2725 PAAARQASPalpaapappavpagPATPGGPARpARPPTTAGPPAPAPpaAPAAGPPRRLTRPAVASLSESRESLPSPWDP 2804

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 2008 REVPAGLESATVTGTPRCSPTrrrslgrAESSPPHTVLPGTWALGGPCSPSVDKYGLGLGPVPRALLQPVPLPhtllsrS 2087
Cdd:PHA03247  2805 ADPPAAVLAPAAALPPAASPA-------GPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRS------P 2871

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 2088 PETCASAWKTESRSPSAGPAPLSSRPSSAPHDfhGHLPSRSEENLFSHLPLHSQHLNRTPCPLIPIGGIQMVQARPGAHP 2167
Cdd:PHA03247  2872 AAKPAAPARPPVRRLARPAVSRSTESFALPPD--QPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDP 2949

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1046888501 2168 TLLSGPCAA----WVSGFSGGGSDLTGAREAQER-SRWSPTES-PSASVSPVAKVSKFTLSSELEEERTSR 2232
Cdd:PHA03247  2950 AGAGEPSGAvpqpWLGALVPGRVAVPRFRVPQPApSREAPASStPPLTGHSLSRVSSWASSLALHEETDPP 3020
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1965-2328 5.12e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 5.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 1965 PARAQASVASTPGPQTGPGRDLSPHLCGSP-RPELSCLTPYPIGREVPA-------GLESATV----------------- 2019
Cdd:PHA03247  2483 PAEARFPFAAGAAPDPGGGGPPDPDAPPAPsRLAPAILPDEPVGEPVHPrmltwirGLEELASddagdpppplppaappa 2562

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 2020 -----TGTPRCSPTRR----RSLGRAESSPPHTVLPGTwalggPCSPSVDkyglglgpvPRALLQPVPLP-HTLLSRSPE 2089
Cdd:PHA03247  2563 apdrsVPPPRPAPRPSepavTSRARRPDAPPQSARPRA-----PVDDRGD---------PRGPAPPSPLPpDTHAPDPPP 2628

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 2090 TCASAWKTESRSPSAGPAPLSSRPSSAPHDFHGHLPSRSEENLFSHLPLHSQHLNRTPCPLIPIGGIQMVqARPGAHPTL 2169
Cdd:PHA03247  2629 PSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSL-ADPPPPPPT 2707

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 2170 LSGPCAAWVSGfsgggSDLTGAREAQERSRWSPTESPSASVSPVAKVskftlsseleeerTSRGPGRPPAwephraeaPA 2249
Cdd:PHA03247  2708 PEPAPHALVSA-----TPLPPGPAAARQASPALPAAPAPPAVPAGPA-------------TPGGPARPAR--------PP 2761

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888501 2250 ETMGTHSPCPPQLPQGHP----LAPSWRGLLESPHALANLKASSFPP---LDRSSSMDCLAETSTCFPPRSRNLSGEPRT 2322
Cdd:PHA03247  2762 TTAGPPAPAPPAAPAAGPprrlTRPAVASLSESRESLPSPWDPADPPaavLAPAAALPPAASPAGPLPPPTSAQPTAPPP 2841


                   ....*.
gi 1046888501 2323 RPDSPE 2328
Cdd:PHA03247  2842 PPGPPP 2847
ZnF_C2H2 smart00355
zinc finger;
1722-1744 6.79e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.90  E-value: 6.79e-03
                            10        20
                    ....*....|....*....|...
gi 1046888501  1722 YVCEECGIRCKKPSMLKKHIRTH 1744
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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