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Conserved domains on  [gi|1046887842|ref|XP_017448734|]
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WD repeat-containing protein 31 isoform X2 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
47-353 2.04e-47

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 165.47  E-value: 2.04e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842  47 RVQTKASQEYIPAHVDTVSVVA-ALNSDLCISGGKDKTAVVYNWKTGHVVRRFIGHEREITKIACIPKSNQFFSASRDKT 125
Cdd:COG2319   106 DLATGLLLRTLTGHTGAVRSVAfSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842 126 VLMWDLQgSSQPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPREPYIVQT 205
Cdd:COG2319   186 VRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASG 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842 206 SEDKTIRLWDCRGLQMAHVFPTKQHIQTHCEVSVDGHTCVScssgfGGEGCEATLWDLrQTRERMCEYKGHFQTVASCVF 285
Cdd:COG2319   265 SADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS-----GSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAF 338

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046887842 286 LPKSAalmpMIATSAHDSKVKIWNQDTGACLSTLSlDGSGPLTSLAV-GDITSLLCASFYRGVHLLRMD 353
Cdd:COG2319   339 SPDGK----TLASGSDDGTVRLWDLATGELLRTLT-GHTGAVTSVAFsPDGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
47-353 2.04e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 165.47  E-value: 2.04e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842  47 RVQTKASQEYIPAHVDTVSVVA-ALNSDLCISGGKDKTAVVYNWKTGHVVRRFIGHEREITKIACIPKSNQFFSASRDKT 125
Cdd:COG2319   106 DLATGLLLRTLTGHTGAVRSVAfSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842 126 VLMWDLQgSSQPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPREPYIVQT 205
Cdd:COG2319   186 VRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASG 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842 206 SEDKTIRLWDCRGLQMAHVFPTKQHIQTHCEVSVDGHTCVScssgfGGEGCEATLWDLrQTRERMCEYKGHFQTVASCVF 285
Cdd:COG2319   265 SADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS-----GSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAF 338

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046887842 286 LPKSAalmpMIATSAHDSKVKIWNQDTGACLSTLSlDGSGPLTSLAV-GDITSLLCASFYRGVHLLRMD 353
Cdd:COG2319   339 SPDGK----TLASGSDDGTVRLWDLATGELLRTLT-GHTGAVTSVAFsPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 57-343 1.91e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 157.50  E-value: 1.91e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842  57 IPAHVDTVSVVAAL-NSDLCISGGKDKTAVVYNWKTGHVVRRFIGHEREITKIACIPKSNQFFSASRDKTVLMWDLQgSS 135
Cdd:cd00200     5 LKGHTGGVTCVAFSpDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE-TG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842 136 QPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPREPYIVQTSEDKTIRLWD 215
Cdd:cd00200    84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842 216 CRGLQMAHVFPTKQHIQTHCEVSVDGHTCVSCSSgfggeGCEATLWDLRQTRErMCEYKGHFQTVASCVFLPKSAalmpM 295
Cdd:cd00200   164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS-----DGTIKLWDLSTGKC-LGTLRGHENGVNSVAFSPDGY----L 233

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1046887842 296 IATSAHDSKVKIWNQDTGACLSTLSLdGSGPLTSLAV-GDITSLLCASF 343
Cdd:cd00200   234 LASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWsPDGKRLASGSA 281
PTZ00421 PTZ00421
coronin; Provisional
 99-217 5.70e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 51.05  E-value: 5.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842  99 IGHEREITKIACIPKSNQ-FFSASRDKTVLMWDL------QGSSQPRQQLSGHAMVVTGLAVSPDSSQ-LCTGSRDNSLL 170
Cdd:PTZ00421   72 LGQEGPIIDVAFNPFDPQkLFTASEDGTIMGWGIpeegltQNISDPIVHLQGHTKKVGIVSFHPSAMNvLASAGADMVVN 151

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1046887842 171 LWDVGTGQCVERASVSRNLVTHLCWVPREPYIVQTSEDKTIRLWDCR 217
Cdd:PTZ00421  152 VWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPR 198
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 134-173 6.45e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 6.45e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1046887842  134 SSQPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWD 173
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
135-173 6.31e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 6.31e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1046887842 135 SQPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWD 173
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
47-353 2.04e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 165.47  E-value: 2.04e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842  47 RVQTKASQEYIPAHVDTVSVVA-ALNSDLCISGGKDKTAVVYNWKTGHVVRRFIGHEREITKIACIPKSNQFFSASRDKT 125
Cdd:COG2319   106 DLATGLLLRTLTGHTGAVRSVAfSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842 126 VLMWDLQgSSQPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPREPYIVQT 205
Cdd:COG2319   186 VRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASG 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842 206 SEDKTIRLWDCRGLQMAHVFPTKQHIQTHCEVSVDGHTCVScssgfGGEGCEATLWDLrQTRERMCEYKGHFQTVASCVF 285
Cdd:COG2319   265 SADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS-----GSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAF 338

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046887842 286 LPKSAalmpMIATSAHDSKVKIWNQDTGACLSTLSlDGSGPLTSLAV-GDITSLLCASFYRGVHLLRMD 353
Cdd:COG2319   339 SPDGK----TLASGSDDGTVRLWDLATGELLRTLT-GHTGAVTSVAFsPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
47-332 1.19e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 163.54  E-value: 1.19e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842  47 RVQTKASQEYIPAHVDTVSVVAALNSDLCISGGKDKTAVVYNWKTGHVVRRFIGHEREITKIACIPKSNQFFSASRDKTV 126
Cdd:COG2319    65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842 127 LMWDLQgSSQPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPREPYIVQTS 206
Cdd:COG2319   145 RLWDLA-TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGS 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842 207 EDKTIRLWDCRGLQMAHVFPTKQHIQTHCEVSVDGHTCVScssgfGGEGCEATLWDLrQTRERMCEYKGHFQTVASCVFL 286
Cdd:COG2319   224 ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLAS-----GSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFS 297

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1046887842 287 PKSAalmpMIATSAHDSKVKIWNQDTGACLSTLSlDGSGPLTSLAV 332
Cdd:COG2319   298 PDGK----LLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAF 338
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 57-343 1.91e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 157.50  E-value: 1.91e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842  57 IPAHVDTVSVVAAL-NSDLCISGGKDKTAVVYNWKTGHVVRRFIGHEREITKIACIPKSNQFFSASRDKTVLMWDLQgSS 135
Cdd:cd00200     5 LKGHTGGVTCVAFSpDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE-TG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842 136 QPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPREPYIVQTSEDKTIRLWD 215
Cdd:cd00200    84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842 216 CRGLQMAHVFPTKQHIQTHCEVSVDGHTCVSCSSgfggeGCEATLWDLRQTRErMCEYKGHFQTVASCVFLPKSAalmpM 295
Cdd:cd00200   164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS-----DGTIKLWDLSTGKC-LGTLRGHENGVNSVAFSPDGY----L 233

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1046887842 296 IATSAHDSKVKIWNQDTGACLSTLSLdGSGPLTSLAV-GDITSLLCASF 343
Cdd:cd00200   234 LASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWsPDGKRLASGSA 281
WD40 COG2319
WD40 repeat [General function prediction only];
76-312 2.03e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.77  E-value: 2.03e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842  76 ISGGKDKTAVVYNWKTGHVVRRFIGHEREITKIACIPKSNQFFSASRDKTVLMWDLQGSsQPRQQLSGHAMVVTGLAVSP 155
Cdd:COG2319   178 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG-KLLRTLTGHSGSVRSVAFSP 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842 156 DSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPREPYIVQTSEDKTIRLWDCRGLQMAHVFPTKQHIQTHC 235
Cdd:COG2319   257 DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1046887842 236 EVSVDGHTCVScssgfGGEGCEATLWDLrQTRERMCEYKGHFQTVASCVFLPKSaalmPMIATSAHDSKVKIWNQDT 312
Cdd:COG2319   337 AFSPDGKTLAS-----GSDDGTVRLWDL-ATGELLRTLTGHTGAVTSVAFSPDG----RTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 60-309 2.63e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 149.02  E-value: 2.63e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842  60 HVDTVSVVAAL-NSDLCISGGKDKTAVVYNWKTGHVVRRFIGHEREITKIACIPKSNQFFSASRDKTVLMWDLQgSSQPR 138
Cdd:cd00200    50 HTGPVRDVAASaDGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE-TGKCL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842 139 QQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPREPYIVQTSEDKTIRLWDCRG 218
Cdd:cd00200   129 TTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842 219 LQMAHVFPTKQHIQTHCEVSVDGHTCVSCSsgfggEGCEATLWDLRqTRERMCEYKGHFQTVASCVFLPKSaalmPMIAT 298
Cdd:cd00200   209 GKCLGTLRGHENGVNSVAFSPDGYLLASGS-----EDGTIRVWDLR-TGECVQTLSGHTNSVTSLAWSPDG----KRLAS 278

                         250
                  ....*....|.
gi 1046887842 299 SAHDSKVKIWN 309
Cdd:cd00200   279 GSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
58-353 1.38e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 147.37  E-value: 1.38e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842  58 PAHVDTVSVVAALNSDLCISGGKDKTAVVYNWKTGHVVRRFIGHEREITKIACIPKSNQFFSASRDKTVLMWDLQGsSQP 137
Cdd:COG2319    34 GLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT-GLL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842 138 RQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPREPYIVQTSEDKTIRLWDCR 217
Cdd:COG2319   113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842 218 GLQMAHVFPTKQHIQTHCEVSVDGHTCVScssgfGGEGCEATLWDLrQTRERMCEYKGHFQTVASCVFLPKSaalmPMIA 297
Cdd:COG2319   193 TGKLLRTLTGHTGAVRSVAFSPDGKLLAS-----GSADGTVRLWDL-ATGKLLRTLTGHSGSVRSVAFSPDG----RLLA 262

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1046887842 298 TSAHDSKVKIWNQDTGACLSTLSlDGSGPLTSLAV-GDITSLLCASFYRGVHLLRMD 353
Cdd:COG2319   263 SGSADGTVRLWDLATGELLRTLT-GHSGGVNSVAFsPDGKLLASGSDDGTVRLWDLA 318
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 95-342 1.87e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 130.92  E-value: 1.87e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842  95 VRRFIGHEREITKIACIPKSNQFFSASRDKTVLMWDLQGSSQPRQqLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDV 174
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRT-LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842 175 GTGQCVERASVSRNLVTHLCWVPREPYIVQTSEDKTIRLWDCRGLQMAHVFPTKQHIQTHCEVSVDGHTCVSCSSgfggE 254
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQ----D 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842 255 GCeATLWDLRQTRERMcEYKGHFQTVASCVFLPKSAalmpMIATSAHDSKVKIWNQDTGACLSTLSLDgSGPLTSLAVGD 334
Cdd:cd00200   157 GT-IKLWDLRTGKCVA-TLTGHTGEVNSVAFSPDGE----KLLSSSSDGTIKLWDLSTGKCLGTLRGH-ENGVNSVAFSP 229


                  ....*...
gi 1046887842 335 ITSLLCAS 342
Cdd:cd00200   230 DGYLLASG 237
WD40 COG2319
WD40 repeat [General function prediction only];
67-349 3.76e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.77  E-value: 3.76e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842  67 VAALNSDLCISGGKDKTAVVYNWKTGHVVRRFIGHEREITKIACIPKSNQFFSASRDKTVLMWDLQGSsQPRQQLSGHAM 146
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG-ALLATLLGHTA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842 147 VVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPREPYIVQTSEDKTIRLWDCRGLQMAHVFP 226
Cdd:COG2319    80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842 227 TKQHIQTHCEVSVDGHTCVScssgfGGEGCEATLWDLRqTRERMCEYKGHFQTVASCVFLPKSAalmpMIATSAHDSKVK 306
Cdd:COG2319   160 GHSGAVTSVAFSPDGKLLAS-----GSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGK----LLASGSADGTVR 229

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1046887842 307 IWNQDTGACLSTLSlDGSGPLTSLAV-GDITSLLCASFYRGVHL 349
Cdd:COG2319   230 LWDLATGKLLRTLT-GHSGSVRSVAFsPDGRLLASGSADGTVRL 272
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 137-342 5.56e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.10  E-value: 5.56e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842 137 PRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPREPYIVQTSEDKTIRLWDC 216
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842 217 RGLQMAHVFptKQHIQ--THCEVSVDGHTCVSCSSgfggeGCEATLWDLRQTRERMCeYKGHFQTVASCVFLPKSaalmP 294
Cdd:cd00200    81 ETGECVRTL--TGHTSyvSSVAFSPDGRILSSSSR-----DKTIKVWDVETGKCLTT-LRGHTDWVNSVAFSPDG----T 148

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1046887842 295 MIATSAHDSKVKIWNQDTGACLSTLSlDGSGPLTSLAVGDITSLLCAS 342
Cdd:cd00200   149 FVASSSQDGTIKLWDLRTGKCVATLT-GHTGEVNSVAFSPDGEKLLSS 195
PTZ00421 PTZ00421
coronin; Provisional
 99-217 5.70e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 51.05  E-value: 5.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842  99 IGHEREITKIACIPKSNQ-FFSASRDKTVLMWDL------QGSSQPRQQLSGHAMVVTGLAVSPDSSQ-LCTGSRDNSLL 170
Cdd:PTZ00421   72 LGQEGPIIDVAFNPFDPQkLFTASEDGTIMGWGIpeegltQNISDPIVHLQGHTKKVGIVSFHPSAMNvLASAGADMVVN 151

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1046887842 171 LWDVGTGQCVERASVSRNLVTHLCWVPREPYIVQTSEDKTIRLWDCR 217
Cdd:PTZ00421  152 VWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPR 198
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 134-173 6.45e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 6.45e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1046887842  134 SSQPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWD 173
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 100-220 3.40e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 48.74  E-value: 3.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842 100 GHEREITKIACIPKSNQFF-SASRDKTVLMWDLQgSSQPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQ 178
Cdd:PTZ00421  123 GHTKKVGIVSFHPSAMNVLaSAGADMVVNVWDVE-RGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGT 201

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1046887842 179 CVERASVSRNLVTHLC-WVPREPYIV----QTSEDKTIRLWDCRGLQ 220
Cdd:PTZ00421  202 IVSSVEAHASAKSQRClWAKRKDLIItlgcSKSQQRQIMLWDTRKMA 248
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 91-130 4.91e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 4.91e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1046887842   91 TGHVVRRFIGHEREITKIACIPKSNQFFSASRDKTVLMWD 130
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
135-173 6.31e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 6.31e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1046887842 135 SQPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWD 173
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 158-330 8.77e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.77  E-value: 8.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842 158 SQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPREPYIVQT-SEDKTIRLWDCRGLQMAHVFPTKQHIqthCE 236
Cdd:PLN00181  546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASgSDDGSVKLWSINQGVSIGTIKTKANI---CC 622

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046887842 237 VSVDGHTCVSCSsgFGGEGCEATLWDLRQTRERMCEYKGHFQTVASCVFLPKSAalmpmIATSAHDSKVKIWNqdtgacl 316
Cdd:PLN00181  623 VQFPSESGRSLA--FGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSST-----LVSSSTDNTLKLWD------- 688

                         170
                  ....*....|....*...
gi 1046887842 317 stLSLDGSG----PLTSL 330
Cdd:PLN00181  689 --LSMSISGinetPLHSF 704
WD40 pfam00400
WD domain, G-beta repeat;
92-130 1.12e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.12e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1046887842  92 GHVVRRFIGHEREITKIACIPKSNQFFSASRDKTVLMWD 130
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 139-203 2.39e-04

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 42.75  E-value: 2.39e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1046887842 139 QQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERAsvSRNLVTHLcwvPREPYIV 203
Cdd:pfam20426 118 QSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSSEKR--SRNTQTEF---PRKDHVI 177
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 176-215 6.06e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 6.06e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1046887842  176 TGQCVERASVSRNLVTHLCWVPREPYIVQTSEDKTIRLWD 215
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
177-215 9.61e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.47  E-value: 9.61e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1046887842 177 GQCVERASVSRNLVTHLCWVPREPYIVQTSEDKTIRLWD 215
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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