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Conserved domains on  [gi|1046880064|ref|XP_017447327|]
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protein zer-1 homolog isoform X11 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1001123)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Oryctolagus cuniculus monocyte differentiation antigen CD14, a coreceptor for bacterial lipopolysaccharide

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
171-288 5.54e-03

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.92  E-value: 5.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880064 171 FEGFSRLRFLNLGR-MIDGIPVEslLRPLNSLTALDLSGIQTSD-ATFLTQWKdSLMSLVLYNMDLSDdhI-RVIVQLHK 247
Cdd:COG4886   155 LGNLTNLKSLDLSNnQLTDLPEE--LGNLTNLKELDLSNNQITDlPEPLGNLT-NLEELDLSGNQLTD--LpEPLANLTN 229

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1046880064 248 LRHLDISRDRLSSyykfkltrkvLSLLvQKLGNLMSLDISG 288
Cdd:COG4886   230 LETLDLSNNQLTD----------LPEL-GNLTNLEELDLSN 259
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
171-288 5.54e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.92  E-value: 5.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880064 171 FEGFSRLRFLNLGR-MIDGIPVEslLRPLNSLTALDLSGIQTSD-ATFLTQWKdSLMSLVLYNMDLSDdhI-RVIVQLHK 247
Cdd:COG4886   155 LGNLTNLKSLDLSNnQLTDLPEE--LGNLTNLKELDLSNNQITDlPEPLGNLT-NLEELDLSGNQLTD--LpEPLANLTN 229

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1046880064 248 LRHLDISRDRLSSyykfkltrkvLSLLvQKLGNLMSLDISG 288
Cdd:COG4886   230 LETLDLSNNQLTD----------LPEL-GNLTNLEELDLSN 259
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
171-288 5.54e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.92  E-value: 5.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880064 171 FEGFSRLRFLNLGR-MIDGIPVEslLRPLNSLTALDLSGIQTSD-ATFLTQWKdSLMSLVLYNMDLSDdhI-RVIVQLHK 247
Cdd:COG4886   155 LGNLTNLKSLDLSNnQLTDLPEE--LGNLTNLKELDLSNNQITDlPEPLGNLT-NLEELDLSGNQLTD--LpEPLANLTN 229

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1046880064 248 LRHLDISRDRLSSyykfkltrkvLSLLvQKLGNLMSLDISG 288
Cdd:COG4886   230 LETLDLSNNQLTD----------LPEL-GNLTNLEELDLSN 259
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
170-281 8.17e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.53  E-value: 8.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880064 170 TFEGFSRLRFLNLGR-MIDGIPVEslLRPLNSLTALDLSGIQTSDATFLTQWKdSLMSLVLYNMDLSDdhIRVIVQLHKL 248
Cdd:COG4886   200 PLGNLTNLEELDLSGnQLTDLPEP--LANLTNLETLDLSNNQLTDLPELGNLT-NLEELDLSNNQLTD--LPPLANLTNL 274

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1046880064 249 RHLDISRDRLSSYYKFKLTRKVLSLLVQKLGNL 281
Cdd:COG4886   275 KTLDLSNNQLTDLKLKELELLLGLNSLLLLLLL 307
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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