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Conserved domains on  [gi|1046874869|ref|XP_017446745|]
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NHL repeat-containing protein 3 isoform X3 [Rattus norvegicus]

Protein Classification

NHL repeat-containing protein( domain architecture ID 110303)

NHL (NCL-1, HT2A and LIN-41) repeat-containing protein may have a catalytic activity or interact with other proteins; NHL is a six-bladed beta-propeller

CATH:  2.40.10.500
Gene Ontology:  GO:0005515
PubMed:  9868369|17979191

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 66-336 3.33e-47

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd14958:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 300  Bit Score: 161.66  E-value: 3.33e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869  66 VAVD-SLNGLVYV-AQRGDDIPkVLVFSEDGYFLRAW--NYTVDtPHGMFVSGtpyEQSVWITDVGSgpygHTVKKYNSL 141
Cdd:cd14958    35 VWDAnSFDANVYVfKGPIEEDT-ILVFDPDGGFLRSWgaGLFYM-PHGLTIDP---DGNIWVTDVGL----HQVFKFDPE 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 142 GDLVQ--VLGTPGKKGTGLNPlqFDNPAELYVDDTGEIYIVDGDGglNNRLVKLSQDFMILWLRGENGTGPAKFNIPHSV 219
Cdd:cd14958   106 GKLLPllTLGERGEPGSDQTH--FCKPTDVAVAPDGDIFVADGYC--NSRIVKFSPDGKLLKSWGEPGSGPGQFNLPHSI 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 220 TLDSVGRVWVADRGNKRLQVFDKDtGEWLGAWDNCFTEEgPSAVRFTPDGRYLIVAQLNLSRLSLLAAPPSGSIGDCTVV 299
Cdd:cd14958   182 ALDEDGRVYVADRENGRIQVFDAD-GKFLTEWTNPELGR-PYALAIDPDGLLYVVDGPPRLNRSLPVRGFVIRIGKGLIL 259

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1046874869 300 STIQLADEVL-----PHLLEVDRKtGAVYVAEIGAKQIQKYV 336
Cdd:cd14958   260 GRFGPGGKAPgqfqnPHDIAVDSG-GDIYVGELGPNRVQKFV 300
 
Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 66-336 3.33e-47

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 161.66  E-value: 3.33e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869  66 VAVD-SLNGLVYV-AQRGDDIPkVLVFSEDGYFLRAW--NYTVDtPHGMFVSGtpyEQSVWITDVGSgpygHTVKKYNSL 141
Cdd:cd14958    35 VWDAnSFDANVYVfKGPIEEDT-ILVFDPDGGFLRSWgaGLFYM-PHGLTIDP---DGNIWVTDVGL----HQVFKFDPE 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 142 GDLVQ--VLGTPGKKGTGLNPlqFDNPAELYVDDTGEIYIVDGDGglNNRLVKLSQDFMILWLRGENGTGPAKFNIPHSV 219
Cdd:cd14958   106 GKLLPllTLGERGEPGSDQTH--FCKPTDVAVAPDGDIFVADGYC--NSRIVKFSPDGKLLKSWGEPGSGPGQFNLPHSI 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 220 TLDSVGRVWVADRGNKRLQVFDKDtGEWLGAWDNCFTEEgPSAVRFTPDGRYLIVAQLNLSRLSLLAAPPSGSIGDCTVV 299
Cdd:cd14958   182 ALDEDGRVYVADRENGRIQVFDAD-GKFLTEWTNPELGR-PYALAIDPDGLLYVVDGPPRLNRSLPVRGFVIRIGKGLIL 259

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1046874869 300 STIQLADEVL-----PHLLEVDRKtGAVYVAEIGAKQIQKYV 336
Cdd:cd14958   260 GRFGPGGKAPgqfqnPHDIAVDSG-GDIYVGELGPNRVQKFV 300
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
66-337 4.33e-16

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 76.98  E-value: 4.33e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869  66 VAVDSlNGLVYVAQRGDDipKVLVFS-EDGYFLRAWNYTVDTPHGMFVSGtpyEQSVWITDVGsgpyGHTVKKYNSLGDL 144
Cdd:COG4257    22 VAVDP-DGAVWFTDQGGG--RIGRLDpATGEFTEYPLGGGSGPHGIAVDP---DGNLWFTDNG----NNRIGRIDPKTGE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 145 VQVLGTPGKKgtglnplqfDNPAELYVDDTGEIYIVDGDgglNNRLVKLSQDfmilwlRGE--NGTGPAKFNIPHSVTLD 222
Cdd:COG4257    92 ITTFALPGGG---------SNPHGIAFDPDGNLWFTDQG---GNRIGRLDPA------TGEvtEFPLPTGGAGPYGIAVD 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 223 SVGRVWVADRGNKRLQVFDKDTGEwLGAWDNCFTEEGPSAVRFTPDGRYLIVAQLN--LSRLSllaaPPSGSigdctvVS 300
Cdd:COG4257   154 PDGNLWVTDFGANAIGRIDPDTGT-LTEYALPTPGAGPRGLAVDPDGNLWVADTGSgrIGRFD----PKTGT------VT 222

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1046874869 301 TIQLAD-EVLPHLLEVDRKtGAVYVAEIGAKQIQKYVP 337
Cdd:COG4257   223 EYPLPGgGARPYGVAVDGD-GRVWFAESGANRIVRFDP 259
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 213-240 2.27e-05

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 40.85  E-value: 2.27e-05
                          10        20
                  ....*....|....*....|....*...
gi 1046874869 213 FNIPHSVTLDSVGRVWVADRGNKRLQVF 240
Cdd:pfam01436   1 FNRPHGVAVDSNGDIYVADSENHRVQVF 28
 
Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 66-336 3.33e-47

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 161.66  E-value: 3.33e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869  66 VAVD-SLNGLVYV-AQRGDDIPkVLVFSEDGYFLRAW--NYTVDtPHGMFVSGtpyEQSVWITDVGSgpygHTVKKYNSL 141
Cdd:cd14958    35 VWDAnSFDANVYVfKGPIEEDT-ILVFDPDGGFLRSWgaGLFYM-PHGLTIDP---DGNIWVTDVGL----HQVFKFDPE 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 142 GDLVQ--VLGTPGKKGTGLNPlqFDNPAELYVDDTGEIYIVDGDGglNNRLVKLSQDFMILWLRGENGTGPAKFNIPHSV 219
Cdd:cd14958   106 GKLLPllTLGERGEPGSDQTH--FCKPTDVAVAPDGDIFVADGYC--NSRIVKFSPDGKLLKSWGEPGSGPGQFNLPHSI 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 220 TLDSVGRVWVADRGNKRLQVFDKDtGEWLGAWDNCFTEEgPSAVRFTPDGRYLIVAQLNLSRLSLLAAPPSGSIGDCTVV 299
Cdd:cd14958   182 ALDEDGRVYVADRENGRIQVFDAD-GKFLTEWTNPELGR-PYALAIDPDGLLYVVDGPPRLNRSLPVRGFVIRIGKGLIL 259

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1046874869 300 STIQLADEVL-----PHLLEVDRKtGAVYVAEIGAKQIQKYV 336
Cdd:cd14958   260 GRFGPGGKAPgqfqnPHDIAVDSG-GDIYVGELGPNRVQKFV 300
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 66-275 2.17e-33

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 124.35  E-value: 2.17e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869  66 VAVDSlNGLVYVAQRGDDipKVLVFSEDGYFLRAW------NYTVDTPHGMFV--SGTpyeqsVWITDVGsgpyGHTVKK 137
Cdd:cd05819    60 VAVDS-DGNLYVADTGNH--RIQKFDPDGNFLASFggsgdgDGEFNGPRGIAVdsSGN-----IYVADTG----NHRIQK 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 138 YNSLGDLVQVLGTPGKkgtglNPLQFDNPAELYVDDTGEIYIVDGDgglNNRLVKLSQDFMILWLRGENGTGPAKFNIPH 217
Cdd:cd05819   128 FDPDGEFLTTFGSGGS-----GPGQFNGPTGVAVDSDGNIYVADTG---NHRIQVFDPDGNFLTTFGSTGTGPGQFNYPT 199

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1046874869 218 SVTLDSVGRVWVADRGNKRLQVFDKDTGEWLGAWDNCFTEEG---PSAVRFTPDGRyLIVA 275
Cdd:cd05819   200 GIAVDSDGNIYVADSGNNRVQVFDPDGAGFGGNGNFLGSDGQfnrPSGLAVDSDGN-LYVA 259
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 66-335 3.77e-32

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 121.27  E-value: 3.77e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869  66 VAVDSlNGLVYVAQRGDDipKVLVFSEDGYFLRAW------NYTVDTPHGMFVSGTpyeQSVWITDVGSgpygHTVKKYN 139
Cdd:cd05819    13 IAVDS-SGNIYVADTGNN--RIQVFDPDGNFITSFgsfgsgDGQFNEPAGVAVDSD---GNLYVADTGN----HRIQKFD 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 140 SLGDLVQVLGtpgkkGTGLNPLQFDNPAELYVDDTGEIYIVDGdggLNNRLVKLSQDFMILWLRGENGTGPAKFNIPHSV 219
Cdd:cd05819    83 PDGNFLASFG-----GSGDGDGEFNGPRGIAVDSSGNIYVADT---GNHRIQKFDPDGEFLTTFGSGGSGPGQFNGPTGV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 220 TLDSVGRVWVADRGNKRLQVFDKDtGEWLGAWDNCFTEEG----PSAVRFTPDGrYLIVAQLNLSRLSLLAA--PPSGSI 293
Cdd:cd05819   155 AVDSDGNIYVADTGNHRIQVFDPD-GNFLTTFGSTGTGPGqfnyPTGIAVDSDG-NIYVADSGNNRVQVFDPdgAGFGGN 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1046874869 294 GDCtVVSTIQLADevlPHLLEVDRKtGAVYVAEIGAKQIQKY 335
Cdd:cd05819   233 GNF-LGSDGQFNR---PSGLAVDSD-GNLYVADTGNNRIQVF 269
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 105-346 2.51e-27

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 108.17  E-value: 2.51e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 105 DTPHGMFVSGtpyEQSVWITDVGsgpyGHTVKKYNSLGDLVQVLGTPGKkgtglNPLQFDNPAELYVDDTGEIYIVDGDg 184
Cdd:cd05819     8 NNPQGIAVDS---SGNIYVADTG----NNRIQVFDPDGNFITSFGSFGS-----GDGQFNEPAGVAVDSDGNLYVADTG- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 185 glNNRLVKLSQD--FMILWlrGENGTGPAKFNIPHSVTLDSVGRVWVADRGNKRLQVFDKDtGEWLGAW------DNCFt 256
Cdd:cd05819    75 --NHRIQKFDPDgnFLASF--GGSGDGDGEFNGPRGIAVDSSGNIYVADTGNHRIQKFDPD-GEFLTTFgsggsgPGQF- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 257 eEGPSAVRFTPDGrYLIVAQLNLSRLSLLAA--PPSGSIGDcTVVSTIQLADevlPHLLEVDRkTGAVYVAEIGAKQIQK 334
Cdd:cd05819   149 -NGPTGVAVDSDG-NIYVADTGNHRIQVFDPdgNFLTTFGS-TGTGPGQFNY---PTGIAVDS-DGNIYVADSGNNRVQV 221

                         250
                  ....*....|..
gi 1046874869 335 YVPWHSRTPALG 346
Cdd:cd05819   222 FDPDGAGFGGNG 233
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 66-335 4.62e-27

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 107.75  E-value: 4.62e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869  66 VAVDSlNGLVYVAQRGDdiPKVLVFSEDGYFLRAWNYTVDTPHGMfvsGTPYEQSV------WITDVGsgpyGHTVKKYN 139
Cdd:cd14956    18 IAVDA-DDNVYVADARN--GRIQVFDKDGTFLRRFGTTGDGPGQF---GRPRGLAVdkdgwlYVADYW----GDRIQVFT 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 140 SLGDLVQVLGTPGKkGTGlnplQFDNPAELYVDDTGEIYIvdGDGGlNNRLVKLSQD--FMILWlrGENGTGPAKFNIPH 217
Cdd:cd14956    88 LTGELQTIGGSSGS-GPG----QFNAPRGVAVDADGNLYV--ADFG-NQRIQKFDPDgsFLRQW--GGTGIEPGSFNYPR 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 218 SVTLDSVGRVWVADRGNKRLQVFDKDtGEWLGAWDNCFTEEG----PSAVRFTPDGRyLIVAQLNLSRLSLLAAP----- 288
Cdd:cd14956   158 GVAVDPDGTLYVADTYNDRIQVFDND-GAFLRKWGGRGTGPGqfnyPYGIAIDPDGN-VFVADFGNNRIQKFTADgtflt 235

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1046874869 289 PSGSIGDctvvSTIQLADevlPHLLEVDRkTGAVYVAEIGAKQIQKY 335
Cdd:cd14956   236 SWGSPGT----GPGQFKN---PWGVVVDA-DGTVYVADSNNNRVQRF 274
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 66-335 1.34e-26

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 106.58  E-value: 1.34e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869  66 VAVDSlNGLVYVAQRGDDipKVLVFSEDGYFLRAW------NYTVDTPHGMFVSGTpyeQSVWITDVgsgpYGHTVKKYN 139
Cdd:cd14957    23 IAVDS-AGNIYVADTGNN--RIQVFTSSGVYSYSIgsggtgSGQFNSPYGIAVDSN---GNIYVADT----DNNRIQVFN 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 140 SLGDLVQVLGTpgkkgTGLNPLQFDNPAELYVDDTGEIYIVDGDgglNNRLVKLSQDFMILWLRGENGTGPAKFNIPHSV 219
Cdd:cd14957    93 SSGVYQYSIGT-----GGSGDGQFNGPYGIAVDSNGNIYVADTG---NHRIQVFTSSGTFSYSIGSGGTGPGQFNGPQGI 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 220 TLDSVGRVWVADRGNKRLQVFDKDtgewlGAWDNCFTEEGPSAVRF-TP-------DGRYLIVAQLNlSRLSLLAAppSG 291
Cdd:cd14957   165 AVDSDGNIYVADTGNHRIQVFTSS-----GTFQYTFGSSGSGPGQFsDPygiavdsDGNIYVADTGN-HRIQVFTS--SG 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1046874869 292 ----SIGdctvvSTIQLADEV-LPHLLEVDrKTGAVYVAEIGAKQIQKY 335
Cdd:cd14957   237 ayqySIG-----TSGSGNGQFnYPYGIAVD-NDGKIYVADSNNNRIQVF 279
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 157-337 5.17e-23

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 96.62  E-value: 5.17e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 157 GLNPLQFDNPAELYVDDTGEIYIVDGDgglNNRLVKLSQDFMILWLRGENGTGPAKFNIPHSVTLDSVGRVWVADRGNKR 236
Cdd:cd05819     1 GTGPGELNNPQGIAVDSSGNIYVADTG---NNRIQVFDPDGNFITSFGSFGSGDGQFNEPAGVAVDSDGNLYVADTGNHR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 237 LQVFDKDtGEWLGAW----DNCFTEEGPSAVRFTPDGRYLIVAQLNlSRLSLLAAppsgsigDCTVVSTI-----QLADE 307
Cdd:cd05819    78 IQKFDPD-GNFLASFggsgDGDGEFNGPRGIAVDSSGNIYVADTGN-HRIQKFDP-------DGEFLTTFgsggsGPGQF 148

                         170       180       190
                  ....*....|....*....|....*....|
gi 1046874869 308 VLPHLLEVDRKtGAVYVAEIGAKQIQKYVP 337
Cdd:cd05819   149 NGPTGVAVDSD-GNIYVADTGNHRIQVFDP 177
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 66-337 1.13e-21

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 93.02  E-value: 1.13e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869  66 VAVDSlNGLVYVAQRGDD-IPKvlvFSEDGYFLRAW------NYTVDTPHGMFV--SGtpyeqSVWITDvgsgPYGHTVK 136
Cdd:cd14955    68 IAVDS-DGNVYVADTGNHrIQK---FDSTGTFLTKWgssgsgDGQFNSPSGIAVdsAG-----NVYVTD----SGNNRIQ 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 137 KYNSLGdlvQVLGTPGKKGTGLNplQFDNPAELYVDDTGEIYIVDGDgglNNRLVKLSQDFMILWLRGENGTGPAKFNIP 216
Cdd:cd14955   135 KFDSSG---TFITKWGSFGSGDG--QFNSPTGIAVDSAGNVYVADTG---NNRIQKFTSTGTFLTKWGSEGSGDGQFNAP 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 217 HSVTLDSVGRVWVADRGNKRLQVFDKdTGEWLGAWDNCFTEEGpsavrftpdgrylivaQLNLsrlsllaapPSGsigdc 296
Cdd:cd14955   207 YGIAVDSAGNVYVADTGNNRIQKFDS-SGTFITKWGSEGSGDG----------------QFNS---------PSG----- 255

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1046874869 297 tvvstiqladevlphlLEVDRkTGAVYVAEIGAKQIQKYVP 337
Cdd:cd14955   256 ----------------IAVDS-AGNVYVADSGNNRIQKFAP 279
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 52-278 1.26e-19

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 87.26  E-value: 1.26e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869  52 WPKNSEYFTGATFCVAVDSlNGLVYV--AQRGddipKVLVFSEDGYFLRAWNYTVDT--PHGMFVSgtPYEQSVWITDVg 127
Cdd:cd14962    48 IGNAGPNRFVSPIGVAIDA-NGNLYVsdAELG----KVFVFDRDGKFLRAIGAGALFkrPTGIAVD--PAGKRLYVVDT- 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 128 sgpYGHTVKKYNSLGDLVQVLGTPGKKgtglnPLQFDNPAELYVDDTGEIYIVDGdggLNNRLVKLSQDFMILWLRGENG 207
Cdd:cd14962   120 ---LAHKVKVFDLDGRLLFDIGKRGSG-----PGEFNLPTDLAVDRDGNLYVTDT---MNFRVQIFDADGKFLRSFGERG 188

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1046874869 208 TGPAKFNIPHSVTLDSVGRVWVADRGNKRLQVFDKdTGEWLGAWDNCFTEEG----PSAVRFTPDGRYLIVAQLN 278
Cdd:cd14962   189 DGPGSFARPKGIAVDSEGNIYVVDAAFDNVQIFNP-EGELLLTVGGPGSGPGefylPSGIAIDKDDRIYVVDQFN 262
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 66-274 1.15e-18

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 84.52  E-value: 1.15e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869  66 VAVDSlNGLVYVAQRGDDipKVLVFSEDGYFLRA--------------WNYTVDTPHGMFVSGTPYEQsVWITDvgsgPY 131
Cdd:cd14954    76 VAVNS-RGRIIVADKDNH--RIQVFDLNGRFLLKfgergtkngqfnypWGVAVDSEGRIYVSDTRNHR-VQVFD----SD 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 132 GHTVKKYNSLGDLvqvlgtpgkkgtglnPLQFDNPAELYVDDTGEIYIVDGDgglNNRLVKLSQDFMILWLRGENGTGPA 211
Cdd:cd14954   148 GQFIRKFGFEGAG---------------PGQLDSPRGVAVNPDGNIVVSDFN---NHRLQVFDPDGQFLRFFGSEGSGNG 209

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1046874869 212 KFNIPHSVTLDSVGRVWVADRGNKRLQVFDKDtGEWL---GAWDNCFTE-EGPSAVRFTPDGRYLIV 274
Cdd:cd14954   210 QFKRPRGVAVDDEGNIIVADSGNHRVQVFSPD-GEFLcsfGTEGNGEGQfDRPSGVAVTPDGRIVVV 275
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 152-335 1.20e-18

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 84.55  E-value: 1.20e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 152 GKKGTGLNplQFDNPAELYVDDTGEIYIVDGDgglNNRLVKLSQD--FMILWlrGENGTGPAKFNIPHSVTLDSVGRVWV 229
Cdd:cd14955     6 GSYGSGDG--QFNSPSGIAVDSAGNVYVADTG---NNRIQKFDSTgtFLTKW--GSSGSGDGQFYSPTGIAVDSDGNVYV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 230 ADRGNKRLQVFDKdTGEWLGAWDNCFTEEG----PSAVRFTPDGrYLIVAQLNLSRL-------SLLAAPPSGSIGDCtv 298
Cdd:cd14955    79 ADTGNHRIQKFDS-TGTFLTKWGSSGSGDGqfnsPSGIAVDSAG-NVYVTDSGNNRIqkfdssgTFITKWGSFGSGDG-- 154

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1046874869 299 vstiQLADevlPHLLEVDrKTGAVYVAEIGAKQIQKY 335
Cdd:cd14955   155 ----QFNS---PTGIAVD-SAGNVYVADTGNNRIQKF 183
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 64-241 3.33e-18

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 83.47  E-value: 3.33e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869  64 FCVAVDSlNGLVYVAQRGDDIpkVLVFSEDGYFLRA------WNYTVDTPHGMFV--SGTPYeqsvwITDVGsgpyGHTV 135
Cdd:cd14957   115 YGIAVDS-NGNIYVADTGNHR--IQVFTSSGTFSYSigsggtGPGQFNGPQGIAVdsDGNIY-----VADTG----NHRI 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 136 KKYNSLGDLVQVLGTPGKkGTGlnplQFDNPAELYVDDTGEIYIVDGDgglNNRLVKLSQDFMILWLRGENGTGPAKFNI 215
Cdd:cd14957   183 QVFTSSGTFQYTFGSSGS-GPG----QFSDPYGIAVDSDGNIYVADTG---NHRIQVFTSSGAYQYSIGTSGSGNGQFNY 254

                         170       180
                  ....*....|....*....|....*.
gi 1046874869 216 PHSVTLDSVGRVWVADRGNKRLQVFD 241
Cdd:cd14957   255 PYGIAVDNDGKIYVADSNNNRIQVFN 280
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 66-240 9.92e-18

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 81.83  E-value: 9.92e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869  66 VAVDSlNGLVYVAQRGDDipKVLVFSEDGYFLRAWNYT------VDTPHGMFVSgtpYEQSVWITDVGSgpygHTVKKYN 139
Cdd:cd14954   123 VAVDS-EGRIYVSDTRNH--RVQVFDSDGQFIRKFGFEgagpgqLDSPRGVAVN---PDGNIVVSDFNN----HRLQVFD 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 140 SLGDLVQVLGTpgkKGTGlnPLQFDNPAELYVDDTGEIYIVDGDgglNNRLVKLSQDFMILWLRGENGTGPAKFNIPHSV 219
Cdd:cd14954   193 PDGQFLRFFGS---EGSG--NGQFKRPRGVAVDDEGNIIVADSG---NHRVQVFSPDGEFLCSFGTEGNGEGQFDRPSGV 264

                         170       180
                  ....*....|....*....|.
gi 1046874869 220 TLDSVGRVWVADRGNKRLQVF 240
Cdd:cd14954   265 AVTPDGRIVVVDRGNHRIQVF 285
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 66-240 1.15e-16

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 78.78  E-value: 1.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869  66 VAVDSLNGLVYVAQRGDDipKVLVFSEDGYFLRAW--------------NYTVDtPHGmfvsgtpyeqSVWITDVGSGpy 131
Cdd:cd14962   105 IAVDPAGKRLYVVDTLAH--KVKVFDLDGRLLFDIgkrgsgpgefnlptDLAVD-RDG----------NLYVTDTMNF-- 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 132 ghTVKKYNSLGDLVQVLGTpgkkgTGLNPLQFDNPAELYVDDTGEIYIVDGDGglnNRLVKLSQDFMILWLRGENGTGPA 211
Cdd:cd14962   170 --RVQIFDADGKFLRSFGE-----RGDGPGSFARPKGIAVDSEGNIYVVDAAF---DNVQIFNPEGELLLTVGGPGSGPG 239

                         170       180
                  ....*....|....*....|....*....
gi 1046874869 212 KFNIPHSVTLDSVGRVWVADRGNKRLQVF 240
Cdd:cd14962   240 EFYLPSGIAIDKDDRIYVVDQFNRRIQVF 268
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 66-240 4.20e-16

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 76.95  E-value: 4.20e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869  66 VAVDSlNGLVYVAQRGDDipKVLVFSEDGYFLRAW-----NYTVDTPHGMFVSGTpyeqSVWITDVGsgpyGHTVKKYNS 140
Cdd:cd14963    61 IAVDS-DGNIYVADLYNG--RIQVFDPDGKFLKYFpekkdRVKLISPAGLAIDDG----KLYVSDVK----KHKVIVFDL 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 141 LGDLVQVLGTPGKKgtglnPLQFDNPAELYVDDTGEIYI--------------------------------------VDG 182
Cdd:cd14963   130 EGKLLLEFGKPGSE-----PGELSYPNGIAVDEDGNIYVadsgngriqvfdkngkfikelngspdgksgfvnprgiaVDP 204

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1046874869 183 DGGL------NNRLVKLSQDFMILWLRGENGTGPAKFNIPHSVTLDSVGRVWVADRGNKRLQVF 240
Cdd:cd14963   205 DGNLyvvdnlSHRVYVFDEQGKELFTFGGRGKDDGQFNLPNGLFIDDDGRLYVTDRENNRVAVY 268
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
66-337 4.33e-16

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 76.98  E-value: 4.33e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869  66 VAVDSlNGLVYVAQRGDDipKVLVFS-EDGYFLRAWNYTVDTPHGMFVSGtpyEQSVWITDVGsgpyGHTVKKYNSLGDL 144
Cdd:COG4257    22 VAVDP-DGAVWFTDQGGG--RIGRLDpATGEFTEYPLGGGSGPHGIAVDP---DGNLWFTDNG----NNRIGRIDPKTGE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 145 VQVLGTPGKKgtglnplqfDNPAELYVDDTGEIYIVDGDgglNNRLVKLSQDfmilwlRGE--NGTGPAKFNIPHSVTLD 222
Cdd:COG4257    92 ITTFALPGGG---------SNPHGIAFDPDGNLWFTDQG---GNRIGRLDPA------TGEvtEFPLPTGGAGPYGIAVD 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 223 SVGRVWVADRGNKRLQVFDKDTGEwLGAWDNCFTEEGPSAVRFTPDGRYLIVAQLN--LSRLSllaaPPSGSigdctvVS 300
Cdd:COG4257   154 PDGNLWVTDFGANAIGRIDPDTGT-LTEYALPTPGAGPRGLAVDPDGNLWVADTGSgrIGRFD----PKTGT------VT 222

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1046874869 301 TIQLAD-EVLPHLLEVDRKtGAVYVAEIGAKQIQKYVP 337
Cdd:COG4257   223 EYPLPGgGARPYGVAVDGD-GRVWFAESGANRIVRFDP 259
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 152-335 9.13e-14

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 70.37  E-value: 9.13e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 152 GKKGTGLNplQFDNPAELYVDDTGEIYIVDGDgglNNRLVKLSQDFMILWLRGENGTGPAKFNIPHSVTLDSVGRVWVAD 231
Cdd:cd14957     8 GSNGSGNG--QFNTPRGIAVDSAGNIYVADTG---NNRIQVFTSSGVYSYSIGSGGTGSGQFNSPYGIAVDSNGNIYVAD 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 232 RGNKRLQVFDKDTGEWL---GAWDNCFTEEGPSAVRFTPDGRyLIVAQLNLSRLSLLAAP--PSGSIGDctvvSTIQLAD 306
Cdd:cd14957    83 TDNNRIQVFNSSGVYQYsigTGGSGDGQFNGPYGIAVDSNGN-IYVADTGNHRIQVFTSSgtFSYSIGS----GGTGPGQ 157

                         170       180
                  ....*....|....*....|....*....
gi 1046874869 307 EVLPHLLEVDRKtGAVYVAEIGAKQIQKY 335
Cdd:cd14957   158 FNGPQGIAVDSD-GNIYVADTGNHRIQVF 185
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 152-337 1.11e-13

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 70.39  E-value: 1.11e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 152 GKKGTGlnPLQFDNPAELYVDDTGEIYIVD------------------------GDGGL--------------------N 187
Cdd:cd14956     3 GGRGSG--PGQFKDPRGIAVDADDNVYVADarngriqvfdkdgtflrrfgttgdGPGQFgrprglavdkdgwlyvadywG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 188 NRLVKLSQDFMILWLRGENGTGPAKFNIPHSVTLDSVGRVWVADRGNKRLQVFDKDtGEWLGAWDNCFTEEG----PSAV 263
Cdd:cd14956    81 DRIQVFTLTGELQTIGGSSGSGPGQFNAPRGVAVDADGNLYVADFGNQRIQKFDPD-GSFLRQWGGTGIEPGsfnyPRGV 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046874869 264 RFTPDGRyLIVAQLNLSRLSLLAAppsgsigDCTVVSTI-----QLADEVLPHLLEVDRKtGAVYVAEIGAKQIQKYVP 337
Cdd:cd14956   160 AVDPDGT-LYVADTYNDRIQVFDN-------DGAFLRKWggrgtGPGQFNYPYGIAIDPD-GNVFVADFGNNRIQKFTA 229
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 66-278 1.90e-13

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 69.63  E-value: 1.90e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869  66 VAVDslNGLVYVAQRGDDipKVLVFSEDGYFLrawnYTV---DTPHGMFvsGTPY------EQSVWITDVGSGpyghTVK 136
Cdd:cd14963    15 VAVS--DGRIYVADTNNH--RVQVFDYEGKFK----KSFggpGTGPGEF--KYPYgiavdsDGNIYVADLYNG----RIQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 137 KYNSLGDLVQVLGTPGKKgtglnpLQFDNPAELYVDDtGEIYIVDGDGglnNRLVKLSQDFMILWLRGENGTGPAKFNIP 216
Cdd:cd14963    81 VFDPDGKFLKYFPEKKDR------VKLISPAGLAIDD-GKLYVSDVKK---HKVIVFDLEGKLLLEFGKPGSEPGELSYP 150

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1046874869 217 HSVTLDSVGRVWVADRGNKRLQVFDKDtGEWL----GAWDNCFTEEGPSAVRFTPDGRYLIVAQLN 278
Cdd:cd14963   151 NGIAVDEDGNIYVADSGNGRIQVFDKN-GKFIkelnGSPDGKSGFVNPRGIAVDPDGNLYVVDNLS 215
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 66-236 2.00e-12

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 67.17  E-value: 2.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869  66 VAVDSlNGLVYVAQRGDD-IPKV--------------LVFSEDGYFLRAwnyTVDTPHG--MFVSGTpyeqsVWITDVGS 128
Cdd:cd14953   137 VAVDA-AGNLYVADTGNHrIRKItpdgvvttvagtggAGYAGDGPATAA---QFNNPTGvaVDAAGN-----LYVADRGN 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 129 gpygHTVKKYNSLGDLVQVLGTPGK---KGTGLNPLQFDNPAELYVDDTGEIYIVDGDgglNNRLVKLSQDFMILWL--- 202
Cdd:cd14953   208 ----HRIRKITPDGVVTTVAGTGTAgfsGDGGATAAQLNNPTGVAVDAAGNLYVADSG---NHRIRKITPAGVVTTVagg 280

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1046874869 203 ----RGENGTG-PAKFNIPHSVTLDSVGRVWVADRGNKR 236
Cdd:cd14953   281 gagfSGDGGPAtSAQFNNPTGVAVDAAGNLYVADTGNNR 319
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 66-251 3.42e-12

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 65.69  E-value: 3.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869  66 VAVDSlNGLVYVAQRGddIPKVLVF------------SEDGYFLRAWNYTVDtPHGmfvsgtpyeqSVWITDVGSGpygh 133
Cdd:cd14962    17 VAADG-RGRIYVADTG--RGAVFVFdlpngkvfvignAGPNRFVSPIGVAID-ANG----------NLYVSDAELG---- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 134 TVKKYNSLGDLVQVLGTPG--KKGTGL--NPLQfdnpAELYVDDTG--EIYIVDGDGglnnrlvKLSQDFmilwlrGENG 207
Cdd:cd14962    79 KVFVFDRDGKFLRAIGAGAlfKRPTGIavDPAG----KRLYVVDTLahKVKVFDLDG-------RLLFDI------GKRG 141

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1046874869 208 TGPAKFNIPHSVTLDSVGRVWVADRGNKRLQVFDKDtGEWLGAW 251
Cdd:cd14962   142 SGPGEFNLPTDLAVDRDGNLYVTDTMNFRVQIFDAD-GKFLRSF 184
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 152-274 4.34e-11

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 62.75  E-value: 4.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 152 GKKGTGLNplQFDNPAELYVDDTGEIYIVDgdggLNNRLVKL-SQDFMILWLRGENGTGPAKFNIPHSVTLDSVGRVWVA 230
Cdd:cd14960   143 GSRGNGDR--QFAGPHFAAVNNNNEIIVTD----FHNHSVKVfNAEGEFLFKFGSNGEGNGQFNAPTGVAVDSNGNIIVA 216

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1046874869 231 DRGNKRLQVFDKdTGEWLGAWDNCF-TEEGPSAVRFTPDGRYLIV 274
Cdd:cd14960   217 DWGNSRIQVFDS-SGSFLSYINTSAdPLYGPQGLALTSDGHVVVA 260
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
226-336 9.60e-11

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 61.25  E-value: 9.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 226 RVWVADRGNKRLQVFDKDTGEWLGAWDncfTEEGPSAVRFTPDGRYLIVAQLNLSRLSLLAAPpsgsigDCTVVSTIQLA 305
Cdd:COG3391    81 RLYVANSGSGRVSVIDLATGKVVATIP---VGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTA------TGKVVATIPVG 151

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1046874869 306 DEvlPHLLEVDRKTGAVYVAEIGAKQIQKYV 336
Cdd:COG3391   152 AG--PHGIAVDPDGKRLYVANSGSNTVSVIV 180
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 66-236 1.03e-10

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 61.78  E-value: 1.03e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869  66 VAVDSlNGLVYVAQRGDD-IPKV----LV----------FSEDGYFLRAwnyTVDTPHGMFV--SGTPYeqsvwITDVGs 128
Cdd:cd14953    82 VAVDA-AGNLYVADTGNHrIRKItpdgVVstlagtgtagFSDDGGATAA---QFNYPTGVAVdaAGNLY-----VADTG- 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 129 gpyGHTVKKYNSLGDLVQVLGTPGKKGTGLNPL---QFDNPAELYVDDTGEIYIVDGDgglNNRLVKLSQDFMI------ 199
Cdd:cd14953   152 ---NHRIRKITPDGVVTTVAGTGGAGYAGDGPAtaaQFNNPTGVAVDAAGNLYVADRG---NHRIRKITPDGVVttvagt 225

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1046874869 200 --LWLRGENGTGPAKFNIPHSVTLDSVGRVWVADRGNKR 236
Cdd:cd14953   226 gtAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGNHR 264
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
164-329 2.86e-09

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 56.63  E-value: 2.86e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 164 DNPAELYVDDTGEIYIVDGDgglNNRLVKLSQDFMILWLRGENGTGPakfnipHSVTLDSVG-RVWVADRGNKRLQVFDK 242
Cdd:COG3391    69 DADGADAGADGRRLYVANSG---SGRVSVIDLATGKVVATIPVGGGP------RGLAVDPDGgRLYVADSGNGRVSVIDT 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 243 DTGEWLGAWDncfTEEGPSAVRFTPDGRYLIVAQLNLSRLSLLAA---PPSGsigdcTVVSTIQLADevLPHLLEVDRKT 319
Cdd:COG3391   140 ATGKVVATIP---VGAGPHGIAVDPDGKRLYVANSGSNTVSVIVSvidTATG-----KVVATIPVGG--GPVGVAVSPDG 209

                         170
                  ....*....|
gi 1046874869 320 GAVYVAEIGA 329
Cdd:COG3391   210 RRLYVANRGS 219
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 149-236 3.38e-09

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 57.15  E-value: 3.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 149 GTPGKKGTGLNPLQFDNPAELYVDDTGEIYIVDGDgglNNRLVKLSQDFMILWLRG------ENGTGP-AKFNIPHSVTL 221
Cdd:cd14953     8 GTAGFSGGGGTAARFNSPSGVAVDAAGNLYVADRG---NHRIRKITPDGVVTTVAGtgtagfADGGGAaAQFNTPSGVAV 84

                          90
                  ....*....|....*
gi 1046874869 222 DSVGRVWVADRGNKR 236
Cdd:cd14953    85 DAAGNLYVADTGNHR 99
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
210-335 2.33e-08

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 54.26  E-value: 2.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 210 PAKFNIPHSVTLDSVGRVWVADRGNKRLQVFDKDTGEWLGAWDNCFTeeGPSAVRFTPDGRyLIVAQLNLSRLSLLaAPP 289
Cdd:COG4257    13 PAPGSGPRDVAVDPDGAVWFTDQGGGRIGRLDPATGEFTEYPLGGGS--GPHGIAVDPDGN-LWFTDNGNNRIGRI-DPK 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1046874869 290 SGSIgdctvvSTIQL-ADEVLPHLLEVDRKtGAVYVAEIGAKQIQKY 335
Cdd:COG4257    89 TGEI------TTFALpGGGSNPHGIAFDPD-GNLWFTDQGGNRIGRL 128
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 152-265 4.74e-08

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 53.71  E-value: 4.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 152 GKKGTGlnPLQFDNPAELYVDDTGEIYIVDGDgglNNRLVKLSQDFMILWLRGENGTGPAKFNIPHSVTLDSVGRVWVAD 231
Cdd:cd14954    14 GKEGSK--DGELCRPWGVAVDKDGRIIVADRS---NNRVQVFDPDGKFLRKFGSYGSRDGQFDRPAGVAVNSRGRIIVAD 88

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1046874869 232 RGNKRLQVFDKDtGEWLGawdnCFTEEGPSAVRF 265
Cdd:cd14954    89 KDNHRIQVFDLN-GRFLL----KFGERGTKNGQF 117
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 152-326 3.34e-07

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 51.12  E-value: 3.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 152 GKKGTGlnPLQFDNPAELYVDDTGEIYIVDgDGglNNRLVKLSQDFMILWLRGENGTGPAKFNIPHSVTLDSVGRVWVAD 231
Cdd:cd14961     1 GSFGGW--PGTLNNPTGVAVTPTGRVVVAD-DG--NKRIQVFDSDGNCLQQFGPKGDAGQDIRYPLDVAVTPDGHIVVTD 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 232 RGNKRLQVFDKDtGEWLGAWDNCFTEegPSAVRFTPDGRYLiVAQLNLSRLSLL-AAPPSGSIGDCTVVSTiQLadeVLP 310
Cdd:cd14961    76 AGDRSVKVFSFD-GRLKLFVRKSFSL--PWGVAVNPSGEIL-VTDSEAGKLFVLtVDFKLGILKKGQKLCS-QL---CRP 147

                         170
                  ....*....|....*.
gi 1046874869 311 HLLEVDRKtGAVYVAE 326
Cdd:cd14961   148 RFVAVSRL-GAVAVTE 162
NHL_brat_like cd14959
NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; ...
 195-274 5.57e-07

NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; Drosophila brain-tumor (brat) has been identified as a tumor suppressor that negatively regulates cell proliferation during development of the Drosophila larval brain. It appears to be recruited to the 3'-untranslated region of hunchback RNA and regulates its translation by forming a complex with Pumilio (Pum) and Nanos (Nos). The NHL domain of brat appears to be involved by interacting with the RNA-binding Puf repeats of Pumilio, a sequence-specific RNA binding protein. This family also contains the Caenorhabditis elegans homolog NCL-1. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271329 [Multi-domain]  Cd Length: 274  Bit Score: 50.35  E-value: 5.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 195 QDFMILWLRGENGTGPAKFNIPHSVTLDSVGRVWVADRGNKRLQVFDKdTGEWLGAWDNCFTEEG----PSAVR-FTPDG 269
Cdd:cd14959     3 SKMIIHCKFGESGSGEGQFNSPSGFCLGEDEDILVADTNNHRIQVFDK-EGEFKFQFGIPGKRDGqlwyPNKVAvCRVTG 81


                  ....*
gi 1046874869 270 RYLIV 274
Cdd:cd14959    82 RYVVT 86
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 164-236 2.19e-06

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 48.36  E-value: 2.19e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1046874869 164 DNPAELYVDDTGEIYIVDGDgglNNRLVKLsqdfmilwLRGENGTGPAKF---NIPHSVTLDSVGRVWVADRGNKR 236
Cdd:cd14952    52 YQPQGVAVDAAGTVYVTDFG---NNRVLKL--------AAGSTTQTVLPFtglNDPTGVAVDAAGNVYVADTGNNR 116
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 66-236 4.21e-06

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 47.20  E-value: 4.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869  66 VAVDSlNGLVYVAQRGDD----------IPKVLVFSedgyflrawnyTVDTPHGMFVSGtpyEQSVWITDVGsgpyGHTV 135
Cdd:cd14952    99 VAVDA-AGNVYVADTGNNrvlklaagsnTQTVLPFT-----------GLSNPDGVAVDG---AGNVYVTDTG----NNRV 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 136 KKYNSLGDLVQVLgtPGkkgTGLNplqfdNPAELYVDDTGEIYIVDGDgglNNRLVKLSQdfmilwlrGENGTGPAKF-- 213
Cdd:cd14952   160 LKLAAGSTTQTVL--PF---TGLN-----SPSGVAVDTAGNVYVTDHG---NNRVLKLAA--------GSTTPTVLPFtg 218

                         170       180
                  ....*....|....*....|....
gi 1046874869 214 -NIPHSVTLDSVGRVWVADRGNKR 236
Cdd:cd14952   219 lNGPLGVAVDAAGNVYVADRGNDR 242
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 118-337 6.32e-06

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 46.81  E-value: 6.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 118 EQSVWITDVgsgpYGHTVKKYNSLGDLVQVLGTPGKKGTGLnplQFDNPAELYV-DDTGEIYIVDGDGGlnnRLVKLSQD 196
Cdd:COG3386    18 DGRLYWVDI----PGGRIHRYDPDGGAVEVFAEPSGRPNGL---AFDPDGRLLVaDHGRGLVRFDPADG---EVTVLADE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 197 FmilwlrgengtgPAKFNIPHSVTLDSVGRVWVAD----RGNKRLQVFDKDtGEwLGAWDNCFTeeGPSAVRFTPDGRYL 272
Cdd:COG3386    88 Y------------GKPLNRPNDGVVDPDGRLYFTDmgeyLPTGALYRVDPD-GS-LRVLADGLT--FPNGIAFSPDGRTL 151

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1046874869 273 IVAQLNLSRLSLLAAPPSGSIGDCTVVSTIQlADEVLPHLLEVDRKtGAVYVAEIGAKQIQKYVP 337
Cdd:COG3386   152 YVADTGAGRIYRFDLDADGTLGNRRVFADLP-DGPGGPDGLAVDAD-GNLWVALWGGGGVVRFDP 214
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 59-236 1.58e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 45.66  E-value: 1.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869  59 FTGATFC--VAVDSlNGLVYVAQRGD----------DIPKVLVFSEdgyflrawnytVDTPHGMFVSGTpyeQSVWITDV 126
Cdd:cd14952     6 FTGLDGPggVAVDA-AGNVYVADSGNnrvlklaagsTTQTVLPFTG-----------LYQPQGVAVDAA---GTVYVTDF 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 127 GSgpyghtvkkynslgDLVQVLgTPGkkGTGLNPLQF---DNPAELYVDDTGEIYIVDGDgglNNRLVKL---SQDFMIL 200
Cdd:cd14952    71 GN--------------NRVLKL-AAG--STTQTVLPFtglNDPTGVAVDAAGNVYVADTG---NNRVLKLaagSNTQTVL 130

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1046874869 201 WLRGENGtgpakfniPHSVTLDSVGRVWVADRGNKR 236
Cdd:cd14952   131 PFTGLSN--------PDGVAVDGAGNVYVTDTGNNR 158
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 213-240 2.27e-05

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 40.85  E-value: 2.27e-05
                          10        20
                  ....*....|....*....|....*...
gi 1046874869 213 FNIPHSVTLDSVGRVWVADRGNKRLQVF 240
Cdd:pfam01436   1 FNRPHGVAVDSNGDIYVADSENHRVQVF 28
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
64-245 2.90e-05

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 45.01  E-value: 2.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869  64 FCVAVDSlNGLVYVAQRGDDipKVLVFS-EDGYFlRAWNYTVD--TPHGMFVSGtpyEQSVWITDVGsgpyGHTVKKYNS 140
Cdd:COG4257   105 HGIAFDP-DGNLWFTDQGGN--RIGRLDpATGEV-TEFPLPTGgaGPYGIAVDP---DGNLWVTDFG----ANAIGRIDP 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 141 LGDLVQVLGTPGkkgtglnplQFDNPAELYVDDTGEIYIVDGDgglNNRLVKLSqdfmilwlrGENGT-----GPAKFNI 215
Cdd:COG4257   174 DTGTLTEYALPT---------PGAGPRGLAVDPDGNLWVADTG---SGRIGRFD---------PKTGTvteypLPGGGAR 232

                         170       180       190
                  ....*....|....*....|....*....|
gi 1046874869 216 PHSVTLDSVGRVWVADRGNKRLQVFDKDTG 245
Cdd:COG4257   233 PYGVAVDGDGRVWFAESGANRIVRFDPDTE 262
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 66-275 4.88e-05

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 44.19  E-value: 4.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869  66 VAVDSlNGLVYVAQRGDDipKVLVFSEDGY--------FLRAWNYTVDtPHGMFVsgtpyeqsvwITDVGSGPYGHTVKK 137
Cdd:cd14961    63 VAVTP-DGHIVVTDAGDR--SVKVFSFDGRlklfvrksFSLPWGVAVN-PSGEIL----------VTDSEAGKLFVLTVD 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 138 YNslgdlVQVLGTPGKKGTGLNplqfdNPAELYVDDTGEIYIVDGDGGLNNRL----VKLSQDFMILW----LRGeNGTG 209
Cdd:cd14961   129 FK-----LGILKKGQKLCSQLC-----RPRFVAVSRLGAVAVTEHLFANGTRSsstrVKVFSSGGQLLgqidSFG-LNLV 197

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046874869 210 PAKFNIPHSVTLDSVGRVWVADRGNKRLQVFDKDTGEWlgawdnCFTEE------GPSAVRFTPDGrYLIVA 275
Cdd:cd14961   198 FPSLICASGVAFDSEGNVIVADTGSGAILCLGKPEGFP------ILKPIvtqglsRPVGLAVTPDG-SLVVL 262
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 66-236 6.20e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 43.74  E-value: 6.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869  66 VAVDSlNGLVYVAQ----------RGDDIPKVLVFSEDGYflrawnytvdtPHGMFVSGtpyEQSVWITDVGSGpyghTV 135
Cdd:cd14952    57 VAVDA-AGTVYVTDfgnnrvlklaAGSTTQTVLPFTGLND-----------PTGVAVDA---AGNVYVADTGNN----RV 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 136 KKYNSLGDLVQVLGTpgkkgTGLNplqfdNPAELYVDDTGEIYIVDGDgglNNRLVKLSQDfmilwlrgenGTGPAKF-- 213
Cdd:cd14952   118 LKLAAGSNTQTVLPF-----TGLS-----NPDGVAVDGAGNVYVTDTG---NNRVLKLAAG----------STTQTVLpf 174

                         170       180
                  ....*....|....*....|....*.
gi 1046874869 214 ---NIPHSVTLDSVGRVWVADRGNKR 236
Cdd:cd14952   175 tglNSPSGVAVDTAGNVYVTDHGNNR 200
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 156-343 1.38e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 42.97  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 156 TGLnplqfDNPAELYVDDTGEIYIVDGDgglNNRLVKLSQdfmilwlrGENGTGPAKFN---IPHSVTLDSVGRVWVADR 232
Cdd:cd14952     7 TGL-----DGPGGVAVDAAGNVYVADSG---NNRVLKLAA--------GSTTQTVLPFTglyQPQGVAVDAAGTVYVTDF 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 233 GNKRLQvfdkdtgeWLGAWDNCFTE------EGPSAVRFTPDGRYLIVAQLNLSRLSLlaapPSGSigdcTVVSTIQLAD 306
Cdd:cd14952    71 GNNRVL--------KLAAGSTTQTVlpftglNDPTGVAVDAAGNVYVADTGNNRVLKL----AAGS----NTQTVLPFTG 134

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1046874869 307 EVLPHLLEVDrKTGAVYVAEIGAKQIQKYVPwHSRTP 343
Cdd:cd14952   135 LSNPDGVAVD-GAGNVYVTDTGNNRVLKLAA-GSTTQ 169
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 163-335 3.10e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 41.80  E-value: 3.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 163 FDNPAELYVDDTGEIYIVDGDGG------LNNRLVklsqdFMIlwlrgeNGTGPAKFNIPHSVTLDSVGRVWVADRGNKR 236
Cdd:cd14962    11 LTRPYGVAADGRGRIYVADTGRGavfvfdLPNGKV-----FVI------GNAGPNRFVSPIGVAIDANGNLYVSDAELGK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 237 LQVFDkdtgewlgawdncfteegpsavrftPDGRYL--IVAQLNLSRlsllaapPSGsigdctvvstiqladevlphlLE 314
Cdd:cd14962    80 VFVFD-------------------------RDGKFLraIGAGALFKR-------PTG---------------------IA 106

                         170       180
                  ....*....|....*....|.
gi 1046874869 315 VDRKTGAVYVAEIGAKQIQKY 335
Cdd:cd14962   107 VDPAGKRLYVVDTLAHKVKVF 127
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 209-293 1.45e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 39.88  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 209 GPAKFNIPHSVTLDSVGRVWVADRGNKRLQVFDKDTGEWlGAWDncFTEEGPSAVRFTPDGRyLIVAQlNLSRLSLLaAP 288
Cdd:COG3386     3 ADAGFRLGEGPVWDPDGRLYWVDIPGGRIHRYDPDGGAV-EVFA--EPSGRPNGLAFDPDGR-LLVAD-HGRGLVRF-DP 76


                  ....*
gi 1046874869 289 PSGSI 293
Cdd:COG3386    77 ADGEV 81
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 169-274 1.64e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 39.49  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 169 LYVDDT--GEIYI--VDGDGGLNNRLVklsqdfmilWLRGENGTGpakfnIPHSVTLDSVGRVWVADRGNKRLQVFDKDt 244
Cdd:COG3386   151 LYVADTgaGRIYRfdLDADGTLGNRRV---------FADLPDGPG-----GPDGLAVDADGNLWVALWGGGGVVRFDPD- 215

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1046874869 245 GEWLGAWDncFTEEGPSAVRF-TPDGRYLIV 274
Cdd:COG3386   216 GELLGRIE--LPERRPTNVAFgGPDLRTLYV 244
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 66-241 8.72e-03

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 37.32  E-value: 8.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869  66 VAVDSlNGLVYVAQrgDDIPKVLVFSEDGYFLRAWNY--TVDT----PHGMFVSGTPyeqSVWITDVGSgpygHTVKKYN 139
Cdd:cd14960   111 VAVDR-NGHIIVVD--NKACCVFIFQPNGKLVTRFGSrgNGDRqfagPHFAAVNNNN---EIIVTDFHN----HSVKVFN 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 140 SLGDLVQVLGTPGKkgtglNPLQFDNPAELYVDDTGEIYIVD-GdgglNNRL--VKLSQDFMilwlrGENGTGPAKFNIP 216
Cdd:cd14960   181 AEGEFLFKFGSNGE-----GNGQFNAPTGVAVDSNGNIIVADwG----NSRIqvFDSSGSFL-----SYINTSADPLYGP 246

                         170       180
                  ....*....|....*....|....*
gi 1046874869 217 HSVTLDSVGRVWVADRGNKRLQVFD 241
Cdd:cd14960   247 QGLALTSDGHVVVADSGNHCFKVYR 271
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
75-245 9.04e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 37.37  E-value: 9.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869  75 VYVAQRGDDipKVLVF-SEDGYFLRAWnYTVDTPHGMFVSgtPYEQSVWITDVGSgpygHTVKKYN-SLGDLVQVLGTPg 152
Cdd:COG3391    82 LYVANSGSG--RVSVIdLATGKVVATI-PVGGGPRGLAVD--PDGGRLYVADSGN----GRVSVIDtATGKVVATIPVG- 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 153 kkgtglnplqfDNPAELYVD-DTGEIYIVDGDgglNNRLVKLsqdfmILWLRGENGTGPAKFNI---PHSVTLDSVGR-V 227
Cdd:COG3391   152 -----------AGPHGIAVDpDGKRLYVANSG---SNTVSVI-----VSVIDTATGKVVATIPVgggPVGVAVSPDGRrL 212

                         170       180
                  ....*....|....*....|....*
gi 1046874869 228 WVADRGN-------KRLQVFDKDTG 245
Cdd:COG3391   213 YVANRGSntsnggsNTVSVIDLATL 237
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 72-246 9.31e-03

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 37.70  E-value: 9.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869  72 NGLVYVaqrGDDIPKVLVFS-EDGYFLraWNYTVDTPHGMFVSGtpyeqSVWITD-----VGSGpYGHTVKKYNSLGDLV 145
Cdd:cd10276   121 DGKIYV---GTGDGRLYYCNaETGKVV--WNRTSTAPELSLRGG-----AAPVGAydvvfVGDG-NGTVVALNTGTGVDI 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046874869 146 QVLGTPGKKGTGLNPLQFDNPAeLYVDDTGEIYIVDGdgglNNRLVKLSQDFM-ILWLRgeNGTGPAkfniphSVTLDSV 224
Cdd:cd10276   190 WEFSVSEPRGRTELPRMIDSSV-TYVVVGGYLYSTSY----QGYLVALDFESGqFLWSR--KASGGT------STSTDAN 256

                         170       180
                  ....*....|....*....|..
gi 1046874869 225 GRVWVADrGNKRLQVFDKDTGE 246
Cdd:cd10276   257 GRVYVGD-GEGSLYCLDASTGD 277
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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