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Conserved domains on  [gi|1046872875|ref|XP_017446413|]
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choline/ethanolaminephosphotransferase 1 isoform X2 [Rattus norvegicus]

Protein Classification

CDP-alcohol phosphatidyltransferase class-I family protein( domain architecture ID 2159)

CDP-alcohol phosphatidyltransferase class-I family protein such as CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase that catalyzes the committed step in the synthesis of acidic phospholipids

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK10832 super family cl00453
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;
43-411 2.90e-44

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;


The actual alignment was detected with superfamily member PLN02359:

Pssm-ID: 469774  Cd Length: 389  Bit Score: 158.40  E-value: 2.90e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875  43 LSRHQLKRLEEHRYQSAGRSLLEP-LMQGYWEWLVGRVPSWIAPNLITIIGLSINICTTILLVFYCPTATEQAPLWAYIA 121
Cdd:PLN02359    4 IGAHGVAALHRYKYSGVDHSYVAKyVLQPFWSRFVNFFPLWMPPNMITLMGFMFLLTSALLGYIYSPHLDTPPPRWVHFA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875 122 CACGLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLSTVFVVLGTCIAVQLGTnpdWMFFCCFAGTFMFYCAHWQTY 201
Cdd:PLN02359   84 HGLLLFLYQTFDAVDGKQARRTNSSSPLGELFDHGCDALACAFETMAFGSTAMCGR---DTFWFWVISAVPFYGATWEHF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875 202 VSGTLRFGIID-VTEVQIFIIIMHLLAVIGGPPFWQ----------SMIPVLN---------IQMKLFPALCTVAgtiFS 261
Cdd:PLN02359  161 FTNTLILPVINgPTEGLMLIYCAHFFTAIVGAEWWAqdfgksipflSWVPFVSeiqtyrivlFLMIAFAVIPTVA---FN 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875 262 CTNYFRVIftggVGKNGSTIAGTSVLSPFLhigsVITLAVMIYKK-SAVQLFEKHPCLYILTFGFVSAKITNKLVVAHM- 339
Cdd:PLN02359  238 VSNVYKVV----QARKGSMLLALAMLYPFV----TLLGGVLIWDYlSPSDLMRNYPHLVVLGTGLAFGFLVGRMILAHLc 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875 340 -------TKSEMHLHDTAF-IGPALLFLDQYFNSFIDEYIVLWIALVFSFFDLIRYCVSVCNQIASHLHIHVFRIKTSTA 411
Cdd:PLN02359  310 depkglkTNMCMSLLYLPFaIANALTARLNDGVPLVDEFWVLLGYCAFTVSLYLHFATSVIHEITTALGIYCFRITRKEA 389
 
Name Accession Description Interval E-value
PLN02359 PLN02359
ethanolaminephosphotransferase
43-411 2.90e-44

ethanolaminephosphotransferase


Pssm-ID: 166000  Cd Length: 389  Bit Score: 158.40  E-value: 2.90e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875  43 LSRHQLKRLEEHRYQSAGRSLLEP-LMQGYWEWLVGRVPSWIAPNLITIIGLSINICTTILLVFYCPTATEQAPLWAYIA 121
Cdd:PLN02359    4 IGAHGVAALHRYKYSGVDHSYVAKyVLQPFWSRFVNFFPLWMPPNMITLMGFMFLLTSALLGYIYSPHLDTPPPRWVHFA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875 122 CACGLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLSTVFVVLGTCIAVQLGTnpdWMFFCCFAGTFMFYCAHWQTY 201
Cdd:PLN02359   84 HGLLLFLYQTFDAVDGKQARRTNSSSPLGELFDHGCDALACAFETMAFGSTAMCGR---DTFWFWVISAVPFYGATWEHF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875 202 VSGTLRFGIID-VTEVQIFIIIMHLLAVIGGPPFWQ----------SMIPVLN---------IQMKLFPALCTVAgtiFS 261
Cdd:PLN02359  161 FTNTLILPVINgPTEGLMLIYCAHFFTAIVGAEWWAqdfgksipflSWVPFVSeiqtyrivlFLMIAFAVIPTVA---FN 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875 262 CTNYFRVIftggVGKNGSTIAGTSVLSPFLhigsVITLAVMIYKK-SAVQLFEKHPCLYILTFGFVSAKITNKLVVAHM- 339
Cdd:PLN02359  238 VSNVYKVV----QARKGSMLLALAMLYPFV----TLLGGVLIWDYlSPSDLMRNYPHLVVLGTGLAFGFLVGRMILAHLc 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875 340 -------TKSEMHLHDTAF-IGPALLFLDQYFNSFIDEYIVLWIALVFSFFDLIRYCVSVCNQIASHLHIHVFRIKTSTA 411
Cdd:PLN02359  310 depkglkTNMCMSLLYLPFaIANALTARLNDGVPLVDEFWVLLGYCAFTVSLYLHFATSVIHEITTALGIYCFRITRKEA 389
EPT1 COG5050
sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases [Lipid transport and ...
56-227 1.07e-26

sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases [Lipid transport and metabolism];


Pssm-ID: 444050  Cd Length: 176  Bit Score: 105.15  E-value: 1.07e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875  56 YQSAGRSLLEPLMQGY-WEWLVGRVPSWIAPNLITIIGLSINICTTILLVFYCPTATeqAPLWAyiaCACGLFIYQSLDA 134
Cdd:COG5050     8 YSVRDRSLLLAFLERYfLRWLAARLPAWVTPNLLTASGALGALAIFVGYLASNGDTG--AYLWL---APVGLIVYWFGDS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875 135 IDGKQARRTNSSSPLGELFDHGCDSLSTVFVVLGTCIAvqLGTNPDWMFFCCFAGTFMFYCAHWQTYVSGTLRFG-IIDV 213
Cdd:COG5050    83 LDGSLARRTGISRPYGEFLDHSLDALATLLIVIGLGLS--PYVRLDVALLALLGYLLLSIHTFWETRVTGEFRLGyLIGP 160
                         170
                  ....*....|....
gi 1046872875 214 TEVQIFIIIMHLLA 227
Cdd:COG5050   161 TELRLILIALTAAM 174
CDP-OH_P_transf pfam01066
CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the ...
82-241 2.50e-06

CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.


Pssm-ID: 460049 [Multi-domain]  Cd Length: 157  Bit Score: 47.17  E-value: 2.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875  82 WIAPNLITIIGLsinICTTILLVFYcptateQAPLWAYIACACgLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLS 161
Cdd:pfam01066   1 LNLPNLLTLLRI---LLVPVFVVLL------LGPGNRILAAVV-FALAALTDFLDGKIARKLNQVTDFGKFLDPLADKLL 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875 162 TVFVVLGTCIAVQLgtnPDWMFFCCFAGTFMFYCAHWQTYVSGTL----RFGIIDvTEVQIFIIIMHLLAVIGGPPFWQS 237
Cdd:pfam01066  71 VAAALIALSILGLL---PWWFVVVILVRELGVTLLRFNVARKGVVipasRGGKIK-TALQMVAIGLLLLPLPGLLPLAGI 146

                  ....
gi 1046872875 238 MIPV 241
Cdd:pfam01066 147 LLWL 150
pgsA TIGR00560
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: ...
85-184 1.60e-03

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: phosphatidylglycerophosphate synthase; glycerophosphate phosphatidyltransferase; PGP synthase. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologs as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273139 [Multi-domain]  Cd Length: 182  Bit Score: 39.26  E-value: 1.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875  85 PNLITIigLSINICTTILLVFYCPTATEQAPLWAyiacACGLFIYQSL-DAIDGKQARRTNSSSPLGELFDHGCDSL--S 161
Cdd:TIGR00560   4 PNWLTL--FRIIALPIFILFFLENVLPIQVSPFI----GALLFIFAAVtDWLDGYLARKWNQVSNFGKFLDPLADKVlvL 77
                          90       100
                  ....*....|....*....|...
gi 1046872875 162 TVFVVLgtciaVQLGTNPDWMFF 184
Cdd:TIGR00560  78 AVLIIL-----VYHGYVPAWFVI 95
 
Name Accession Description Interval E-value
PLN02359 PLN02359
ethanolaminephosphotransferase
43-411 2.90e-44

ethanolaminephosphotransferase


Pssm-ID: 166000  Cd Length: 389  Bit Score: 158.40  E-value: 2.90e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875  43 LSRHQLKRLEEHRYQSAGRSLLEP-LMQGYWEWLVGRVPSWIAPNLITIIGLSINICTTILLVFYCPTATEQAPLWAYIA 121
Cdd:PLN02359    4 IGAHGVAALHRYKYSGVDHSYVAKyVLQPFWSRFVNFFPLWMPPNMITLMGFMFLLTSALLGYIYSPHLDTPPPRWVHFA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875 122 CACGLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLSTVFVVLGTCIAVQLGTnpdWMFFCCFAGTFMFYCAHWQTY 201
Cdd:PLN02359   84 HGLLLFLYQTFDAVDGKQARRTNSSSPLGELFDHGCDALACAFETMAFGSTAMCGR---DTFWFWVISAVPFYGATWEHF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875 202 VSGTLRFGIID-VTEVQIFIIIMHLLAVIGGPPFWQ----------SMIPVLN---------IQMKLFPALCTVAgtiFS 261
Cdd:PLN02359  161 FTNTLILPVINgPTEGLMLIYCAHFFTAIVGAEWWAqdfgksipflSWVPFVSeiqtyrivlFLMIAFAVIPTVA---FN 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875 262 CTNYFRVIftggVGKNGSTIAGTSVLSPFLhigsVITLAVMIYKK-SAVQLFEKHPCLYILTFGFVSAKITNKLVVAHM- 339
Cdd:PLN02359  238 VSNVYKVV----QARKGSMLLALAMLYPFV----TLLGGVLIWDYlSPSDLMRNYPHLVVLGTGLAFGFLVGRMILAHLc 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875 340 -------TKSEMHLHDTAF-IGPALLFLDQYFNSFIDEYIVLWIALVFSFFDLIRYCVSVCNQIASHLHIHVFRIKTSTA 411
Cdd:PLN02359  310 depkglkTNMCMSLLYLPFaIANALTARLNDGVPLVDEFWVLLGYCAFTVSLYLHFATSVIHEITTALGIYCFRITRKEA 389
PTZ00307 PTZ00307
ethanolamine phosphotransferase; Provisional
21-407 3.65e-39

ethanolamine phosphotransferase; Provisional


Pssm-ID: 140328  Cd Length: 417  Bit Score: 145.36  E-value: 3.65e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875  21 GFGHMSTTGCILNKLFQLPTPPlsrHQLKRLEEHRYQSAGRSLLEP-LMQGYWEWLVGRVPSWIAPNLITIIGLSINICT 99
Cdd:PTZ00307    1 MPPKSTARRISLNPLENEYIPP---AYLPNLKKYKYSSTDSSIISRyVLQRYWNFIVNLVPMTVAPNCITFTGFLIGMSS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875 100 TILLVFYCPTATEQAPLWAYIACACGLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLSTVFVVLGTCIAVQLgtnP 179
Cdd:PTZ00307   78 AALLLYFYFFEEGVYPSWVLYYAAFALFAYQTLDAIDGKQARRTGTGSPLGELFDHGCDAFLTPFVLLNVSLATYM---T 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875 180 DWMFFCCFA-GTFMFYCAHWQTYVSGTLRFGIID-VTEVQIFIIIMHLLAVIGGPPFWQSM------IPVLNIQMKLFPA 251
Cdd:PTZ00307  155 PVERFWLSTiSSMSLFTAIWEQFSTGTFDLGYVNgPTEGIILNCVLFIVSGVYGESIWDTPavgpydVAYPPVLSSFFPG 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875 252 ----------------LCTVAGTIFSCTNYFRVIFTGGVGKNGSTiagtsvlsPFLHIGSVITLAVMIYKKSAV--QLFE 313
Cdd:PTZ00307  235 csgtvhiesvrsvlflLFLVSCPFTILTNVVHVVLRPTVHASKVT--------PMLAALPILTMTALHVHVFVVfpNLHV 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875 314 KHPCLYILTFGFVSAKITNKLVVAHMTKSEMHLHDTAFI------GPALLFLDQYFNSFIDEYI--VLWIAL----VFSF 381
Cdd:PTZ00307  307 KFPFALELSYGLLMSITVTRLTLARLSAMPYRTFNWHIVitflalTAASLMHYAGDASVEHKYVepSLGWALtglaVFAA 386
                         410       420
                  ....*....|....*....|....*.
gi 1046872875 382 FDLIRYCVSVCNQIASHLHIHVFRIK 407
Cdd:PTZ00307  387 WQYGHMILSAFTQIARYLSISIMSIK 412
PLN03039 PLN03039
ethanolaminephosphotransferase; Provisional
91-411 7.78e-29

ethanolaminephosphotransferase; Provisional


Pssm-ID: 166679  Cd Length: 337  Bit Score: 115.48  E-value: 7.78e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875  91 IGLSINICTTILLVFYCPTATEQAPLWAYIACACGLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLSTVFVVLGTC 170
Cdd:PLN03039    1 MGFMFLLTSALLGYIYSPKLDSPPPRWVHFAHGLLLFLYQTFDAVDGKQARRTNSSSPLGELFDHGCDALACAFEAMAFG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875 171 IAVQLGTNPDWMFFCcfaGTFMFYCAHWQTYVSGTLRFGIID-VTEVQIFIIIMHLLAVIGGPPFWQ----------SMI 239
Cdd:PLN03039   81 STAMCGRDTFWFWVI---SAIPFFGATWEHYFTNTLILPVINgPTEGLALIFCGHFFTAIVGAEWWAqpfgksiplfSWV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875 240 PVLN---------IQMKLFPALCTVAgtiFSCTNYFRVIFTggvgKNGSTIAGTSVLSPFLhigsVITLAVMIYKK-SAV 309
Cdd:PLN03039  158 PFLNeiqmsrailFMMIAFAVIPTLA---FNTSNVYKVVHS----RNGSMLLALAMLYPFV----TLIAGVLIWDYlSPI 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875 310 QLFEKHPCLYILTFGFVSAKITNKLVVAHMTKSEMHLHDTAFIgpALLFLDQYFNSFIDEYIVLWIALVFSFFDLIRYCV 389
Cdd:PLN03039  227 DLIANYPHLVVLGTGLAFGFLVGRMILAHLCDEPKGLKTNMCM--SLLYLPFALANALTARLNAGVPLVDEFWVLLGYCI 304
                         330       340       350
                  ....*....|....*....|....*....|...
gi 1046872875 390 -----------SVCNQIASHLHIHVFRIKTSTA 411
Cdd:PLN03039  305 ftlslyahfatSVIHEITEALGIYCFRITRKEA 337
EPT1 COG5050
sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases [Lipid transport and ...
56-227 1.07e-26

sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases [Lipid transport and metabolism];


Pssm-ID: 444050  Cd Length: 176  Bit Score: 105.15  E-value: 1.07e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875  56 YQSAGRSLLEPLMQGY-WEWLVGRVPSWIAPNLITIIGLSINICTTILLVFYCPTATeqAPLWAyiaCACGLFIYQSLDA 134
Cdd:COG5050     8 YSVRDRSLLLAFLERYfLRWLAARLPAWVTPNLLTASGALGALAIFVGYLASNGDTG--AYLWL---APVGLIVYWFGDS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875 135 IDGKQARRTNSSSPLGELFDHGCDSLSTVFVVLGTCIAvqLGTNPDWMFFCCFAGTFMFYCAHWQTYVSGTLRFG-IIDV 213
Cdd:COG5050    83 LDGSLARRTGISRPYGEFLDHSLDALATLLIVIGLGLS--PYVRLDVALLALLGYLLLSIHTFWETRVTGEFRLGyLIGP 160
                         170
                  ....*....|....
gi 1046872875 214 TEVQIFIIIMHLLA 227
Cdd:COG5050   161 TELRLILIALTAAM 174
PgsA COG0558
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; ...
82-235 8.28e-11

Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; Phosphatidylglycerophosphate synthase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440324 [Multi-domain]  Cd Length: 177  Bit Score: 60.64  E-value: 8.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875  82 WIAPNLITIIGLsinICTTILLVFYcptATEQAPLWAyiacACGLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLS 161
Cdd:COG0558     9 LNIPNQLTLLRI---LLVPVFALLL---LLGGALLLA----LVLFLLAGLTDALDGYLARRLGQVSRFGAFLDPVADKLL 78
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1046872875 162 TVFVVLGtciAVQLGTNPDWMFFCCFAGTFM-FYCAHW-QTYVSGTLRFGIIDvTEVQIFIIIMHLLAVIG-GPPFW 235
Cdd:COG0558    79 DAAALLG---LVLLGLLPAWLALLILLRELLvSYLRARaAALGVVASYLGKAK-TVLQLVAILLLLLGLPLlGVLLW 151
CDP-OH_P_transf pfam01066
CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the ...
82-241 2.50e-06

CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.


Pssm-ID: 460049 [Multi-domain]  Cd Length: 157  Bit Score: 47.17  E-value: 2.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875  82 WIAPNLITIIGLsinICTTILLVFYcptateQAPLWAYIACACgLFIYQSLDAIDGKQARRTNSSSPLGELFDHGCDSLS 161
Cdd:pfam01066   1 LNLPNLLTLLRI---LLVPVFVVLL------LGPGNRILAAVV-FALAALTDFLDGKIARKLNQVTDFGKFLDPLADKLL 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875 162 TVFVVLGTCIAVQLgtnPDWMFFCCFAGTFMFYCAHWQTYVSGTL----RFGIIDvTEVQIFIIIMHLLAVIGGPPFWQS 237
Cdd:pfam01066  71 VAAALIALSILGLL---PWWFVVVILVRELGVTLLRFNVARKGVVipasRGGKIK-TALQMVAIGLLLLPLPGLLPLAGI 146

                  ....
gi 1046872875 238 MIPV 241
Cdd:pfam01066 147 LLWL 150
PssA COG1183
Phosphatidylserine synthase [Lipid transport and metabolism];
78-188 5.76e-04

Phosphatidylserine synthase [Lipid transport and metabolism];


Pssm-ID: 440796 [Multi-domain]  Cd Length: 237  Bit Score: 41.34  E-value: 5.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875  78 RVPSWIAPNLITIIGLsinICTTILLVFycptATEQAPLWAYIACACGLFiyqsLDAIDGKQARRTNSSSPLGELFDHGC 157
Cdd:COG1183     6 RRAIYLLPNLFTLLNL---FCGFLAIVA----AIEGDFELAALLILLAAV----FDGLDGRVARLLNVQSEFGAELDSLA 74
                          90       100       110
                  ....*....|....*....|....*....|...
gi 1046872875 158 DSLStvFVVLGTCIAVQLGTNPD--WMFFCCFA 188
Cdd:COG1183    75 DMVS--FGVAPALLLYQWGLLPLggLGWLAAFL 105
pgsA TIGR00560
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: ...
85-184 1.60e-03

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: phosphatidylglycerophosphate synthase; glycerophosphate phosphatidyltransferase; PGP synthase. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologs as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273139 [Multi-domain]  Cd Length: 182  Bit Score: 39.26  E-value: 1.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046872875  85 PNLITIigLSINICTTILLVFYCPTATEQAPLWAyiacACGLFIYQSL-DAIDGKQARRTNSSSPLGELFDHGCDSL--S 161
Cdd:TIGR00560   4 PNWLTL--FRIIALPIFILFFLENVLPIQVSPFI----GALLFIFAAVtDWLDGYLARKWNQVSNFGKFLDPLADKVlvL 77
                          90       100
                  ....*....|....*....|...
gi 1046872875 162 TVFVVLgtciaVQLGTNPDWMFF 184
Cdd:TIGR00560  78 AVLIIL-----VYHGYVPAWFVI 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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