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Conserved domains on  [gi|1046844362|ref|XP_017445231|]
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TATA box-binding protein-like 1 isoform X4 [Rattus norvegicus]

Protein Classification

TBP family protein( domain architecture ID 10139978)

TBP family protein similar to TATA-box-binding protein (TBP), a general transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID

Gene Ontology:  GO:0006352|GO:0003677

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TLF cd04517
TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and ...
9-212 4.66e-91

TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the basal transcription machinery. Yet, in contrast to TBPs, TLFs seem not to interact with the TATA-box and even have a negative effect on the transcription of TATA-containing promoters. Recent results indicate that TLFs are involved in the transcription via TATA-less promoters.


:

Pssm-ID: 239953  Cd Length: 174  Bit Score: 264.58  E-value: 4.66e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046844362   9 LDILITNVVCVFRTRCHLNLRKIALEGANVIYKRDVGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSL 88
Cdd:cd04517     1 LDILIVNVVCQFSLRCHIDLRKLALAGRNVEYNPRYPKVTMRLREPRATASVWSSGKITITGATSEEEAKQAARRAARLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046844362  89 QKLGFQVI-FTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTGnldlmh 167
Cdd:cd04517    81 QKLGFKVVrFSNFRVVNVLATCSMPFPIRLDELAAKNRSSASYEPELHPGVVYRITGPRATLSIFSTGSVTVTG------ 154
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1046844362 168 tcselhhsllmdaalscvgsrssssGPNVKAVATAVEQIYPFVFE 212
Cdd:cd04517   155 -------------------------ARSMEDVREAVEKIYPIVFE 174
 
Name Accession Description Interval E-value
TLF cd04517
TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and ...
9-212 4.66e-91

TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the basal transcription machinery. Yet, in contrast to TBPs, TLFs seem not to interact with the TATA-box and even have a negative effect on the transcription of TATA-containing promoters. Recent results indicate that TLFs are involved in the transcription via TATA-less promoters.


Pssm-ID: 239953  Cd Length: 174  Bit Score: 264.58  E-value: 4.66e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046844362   9 LDILITNVVCVFRTRCHLNLRKIALEGANVIYKRDVGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSL 88
Cdd:cd04517     1 LDILIVNVVCQFSLRCHIDLRKLALAGRNVEYNPRYPKVTMRLREPRATASVWSSGKITITGATSEEEAKQAARRAARLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046844362  89 QKLGFQVI-FTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTGnldlmh 167
Cdd:cd04517    81 QKLGFKVVrFSNFRVVNVLATCSMPFPIRLDELAAKNRSSASYEPELHPGVVYRITGPRATLSIFSTGSVTVTG------ 154
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1046844362 168 tcselhhsllmdaalscvgsrssssGPNVKAVATAVEQIYPFVFE 212
Cdd:cd04517   155 -------------------------ARSMEDVREAVEKIYPIVFE 174
PLN00062 PLN00062
TATA-box-binding protein; Provisional
13-161 1.19e-43

TATA-box-binding protein; Provisional


Pssm-ID: 177693 [Multi-domain]  Cd Length: 179  Bit Score: 144.45  E-value: 1.19e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046844362  13 ITNVVCVFRTRCHLNLRKIALEGANVIYK-RDVGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSLQKL 91
Cdd:PLN00062    4 LQNIVSTVNLDCKLDLKKIALQARNAEYNpKRFAAVIMRIREPKTTALIFASGKMVCTGAKSEHDSKLAARKYARIIQKL 83
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046844362  92 GFQVIFTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTG 161
Cdd:PLN00062   84 GFPAKFKDFKIQNIVGSCDVKFPIRLEGLAYAHGAFSSYEPELFPGLIYRMKQPKIVLLIFVSGKIVITG 153
TBP pfam00352
Transcription factor TFIID (or TATA-binding protein, TBP);
10-91 1.12e-26

Transcription factor TFIID (or TATA-binding protein, TBP);


Pssm-ID: 425630 [Multi-domain]  Cd Length: 84  Bit Score: 97.89  E-value: 1.12e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046844362  10 DILITNVVCVFRTRCHLNLRKIALEGA-NVIYKRDV-GKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARS 87
Cdd:pfam00352   1 DIKIQNVVASADLGFPIDLEKLALKLLeNVEYEPERfPGLVYRLREPKVTALIFSSGKIVITGAKSEEDAKKAIRKIAPI 80

                  ....
gi 1046844362  88 LQKL 91
Cdd:pfam00352  81 LQKL 84
SPT15 COG2101
TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];
13-161 1.50e-24

TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];


Pssm-ID: 441704  Cd Length: 180  Bit Score: 95.27  E-value: 1.50e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046844362  13 ITNVVCVFRTRCHLNLRKIALEGANVIYKRDV--GKVLmKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSLQK 90
Cdd:COG2101     6 IENIVASGSLGQELDLEKLAEDLPNAEYNPEQfpGLVY-RLKEPKTAALIFRSGKMVCTGAKSEEDLIEAVEKVIEKLRK 84
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046844362  91 LGFQVI-FTDFKVVNVLAVCNMPFEIRLpeftknNR-------PHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTG 161
Cdd:COG2101    85 LGIEIPdEPEITVQNIVASADLGREINL------NAlaiglglENIEYEPEQFPGLVYRLDDPKVVLLLFSSGKLVITG 157
 
Name Accession Description Interval E-value
TLF cd04517
TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and ...
9-212 4.66e-91

TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the basal transcription machinery. Yet, in contrast to TBPs, TLFs seem not to interact with the TATA-box and even have a negative effect on the transcription of TATA-containing promoters. Recent results indicate that TLFs are involved in the transcription via TATA-less promoters.


Pssm-ID: 239953  Cd Length: 174  Bit Score: 264.58  E-value: 4.66e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046844362   9 LDILITNVVCVFRTRCHLNLRKIALEGANVIYKRDVGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSL 88
Cdd:cd04517     1 LDILIVNVVCQFSLRCHIDLRKLALAGRNVEYNPRYPKVTMRLREPRATASVWSSGKITITGATSEEEAKQAARRAARLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046844362  89 QKLGFQVI-FTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTGnldlmh 167
Cdd:cd04517    81 QKLGFKVVrFSNFRVVNVLATCSMPFPIRLDELAAKNRSSASYEPELHPGVVYRITGPRATLSIFSTGSVTVTG------ 154
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1046844362 168 tcselhhsllmdaalscvgsrssssGPNVKAVATAVEQIYPFVFE 212
Cdd:cd04517   155 -------------------------ARSMEDVREAVEKIYPIVFE 174
TBP_TLF cd00652
TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription ...
10-212 5.52e-76

TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA. New members of the TBP family, called TBP-like proteins (TBLP, TLF, TLP) or TBP-related factors (TRF1, TRF2,TRP), are similar to the core domain of TBPs, with identical or chemically similar amino acids at many equivalent positions, suggesting similar structure. However, TLFs contain distinct, conserved amino acids at several positions that distinguish them from TBP.


Pssm-ID: 238352 [Multi-domain]  Cd Length: 174  Bit Score: 226.27  E-value: 5.52e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046844362  10 DILITNVVCVFRTRCHLNLRKIALEGANVIYKRD-VGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSL 88
Cdd:cd00652     1 SPKIQNIVATVNLGCELDLRKIALAARNAEYNPKrFPGVIMRLREPKTTALIFSSGKMVITGAKSEEDAKLAARKYARIL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046844362  89 QKLGFQVI-FTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTGnldlmh 167
Cdd:cd00652    81 QKLGFPVEkFPEFKVQNIVASCDLGFPIRLEELALKHPENASYEPELFPGLIYRMDEPKVVLLIFVSGKIVITG------ 154
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1046844362 168 tcselhhsllmdaalscvgsrssssGPNVKAVATAVEQIYPFVFE 212
Cdd:cd00652   155 -------------------------AKSREDIYEAVEKIYPILKE 174
TBP_eukaryotes cd04516
eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are ...
13-161 9.84e-48

eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


Pssm-ID: 239952  Cd Length: 174  Bit Score: 154.68  E-value: 9.84e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046844362  13 ITNVVCVFRTRCHLNLRKIALEGANVIY--KRdVGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSLQK 90
Cdd:cd04516     4 IQNIVATVNLGCKLDLKKIALRARNAEYnpKR-FAAVIMRIREPKTTALIFSSGKMVCTGAKSEDDSKLAARKYARIIQK 82
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1046844362  91 LGFQVIFTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTG 161
Cdd:cd04516    83 LGFPAKFTDFKIQNIVGSCDVKFPIRLEGLAHAHKQFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTG 153
PLN00062 PLN00062
TATA-box-binding protein; Provisional
13-161 1.19e-43

TATA-box-binding protein; Provisional


Pssm-ID: 177693 [Multi-domain]  Cd Length: 179  Bit Score: 144.45  E-value: 1.19e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046844362  13 ITNVVCVFRTRCHLNLRKIALEGANVIYK-RDVGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSLQKL 91
Cdd:PLN00062    4 LQNIVSTVNLDCKLDLKKIALQARNAEYNpKRFAAVIMRIREPKTTALIFASGKMVCTGAKSEHDSKLAARKYARIIQKL 83
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046844362  92 GFQVIFTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTG 161
Cdd:PLN00062   84 GFPAKFKDFKIQNIVGSCDVKFPIRLEGLAYAHGAFSSYEPELFPGLIYRMKQPKIVLLIFVSGKIVITG 153
TBP pfam00352
Transcription factor TFIID (or TATA-binding protein, TBP);
10-91 1.12e-26

Transcription factor TFIID (or TATA-binding protein, TBP);


Pssm-ID: 425630 [Multi-domain]  Cd Length: 84  Bit Score: 97.89  E-value: 1.12e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046844362  10 DILITNVVCVFRTRCHLNLRKIALEGA-NVIYKRDV-GKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARS 87
Cdd:pfam00352   1 DIKIQNVVASADLGFPIDLEKLALKLLeNVEYEPERfPGLVYRLREPKVTALIFSSGKIVITGAKSEEDAKKAIRKIAPI 80

                  ....
gi 1046844362  88 LQKL 91
Cdd:pfam00352  81 LQKL 84
SPT15 COG2101
TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];
13-161 1.50e-24

TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];


Pssm-ID: 441704  Cd Length: 180  Bit Score: 95.27  E-value: 1.50e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046844362  13 ITNVVCVFRTRCHLNLRKIALEGANVIYKRDV--GKVLmKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSLQK 90
Cdd:COG2101     6 IENIVASGSLGQELDLEKLAEDLPNAEYNPEQfpGLVY-RLKEPKTAALIFRSGKMVCTGAKSEEDLIEAVEKVIEKLRK 84
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046844362  91 LGFQVI-FTDFKVVNVLAVCNMPFEIRLpeftknNR-------PHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTG 161
Cdd:COG2101    85 LGIEIPdEPEITVQNIVASADLGREINL------NAlaiglglENIEYEPEQFPGLVYRLDDPKVVLLLFSSGKLVITG 157
TBP_archaea cd04518
archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and ...
13-161 4.11e-24

archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and eukaryotes, that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


Pssm-ID: 239954  Cd Length: 174  Bit Score: 93.85  E-value: 4.11e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046844362  13 ITNVVCVFRTRCHLNLRKIALEGANVIYKRDVGK-VLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSLQKL 91
Cdd:cd04518     4 IENIVASVDLGQELDLEKVAAELPNAEYNPDQFPgLVYRLEDPKIAALIFRSGKMVCTGAKSVEDLHRAVKEIIKKLKDY 83
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1046844362  92 GFQVIF-TDFKVVNVLAVCNMPFEIRLpeftknNR-----PHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTG 161
Cdd:cd04518    84 GIKVIEkPEIKVQNIVASADLGREVNL------DAiaiglPNAEYEPEQFPGLVYRLDEPKVVLLLFSSGKMVITG 153
PRK00394 PRK00394
transcription factor; Reviewed
11-161 7.99e-24

transcription factor; Reviewed


Pssm-ID: 234746  Cd Length: 179  Bit Score: 93.38  E-value: 7.99e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046844362  11 ILITNVVCVFRTRCHLNLRKIALEGANVIYKRDV--GKVLmKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSL 88
Cdd:PRK00394    1 IKIENIVASTDLGQELDLEKVAEDLPNAEYNPEQfpGLVY-RLEDPKIAALIFRSGKVVCTGAKSVEDLHEAVKIIIKKL 79
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1046844362  89 QKLGFQVIF-TDFKVVNVLAVCNMPFEIRLPEFTKN-NRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTG 161
Cdd:PRK00394   80 KELGIKVIDePEIKVQNIVASADLGVELNLNAIAIGlGLENIEYEPEQFPGLVYRLDDPKVVVLLFGSGKLVITG 154
TBP pfam00352
Transcription factor TFIID (or TATA-binding protein, TBP);
99-161 4.97e-22

Transcription factor TFIID (or TATA-binding protein, TBP);


Pssm-ID: 425630 [Multi-domain]  Cd Length: 84  Bit Score: 85.95  E-value: 4.97e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1046844362  99 DFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTG 161
Cdd:pfam00352   1 DIKIQNVVASADLGFPIDLEKLALKLLENVEYEPERFPGLVYRLREPKVTALIFSSGKIVITG 63
PRK00394 PRK00394
transcription factor; Reviewed
10-92 2.16e-10

transcription factor; Reviewed


Pssm-ID: 234746  Cd Length: 179  Bit Score: 57.55  E-value: 2.16e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046844362  10 DILITNVVCVFRTRCHLNLRKIA----LEGAN--------VIYKrdvgkvlmkLRKPRITATIWSSGKIICTGATSEEEA 77
Cdd:PRK00394   91 EIKVQNIVASADLGVELNLNAIAiglgLENIEyepeqfpgLVYR---------LDDPKVVVLLFGSGKLVITGAKSEEDA 161
                          90
                  ....*....|....*
gi 1046844362  78 KFGARRLARSLQKLG 92
Cdd:PRK00394  162 EKAVEKILEKLEELG 176
SPT15 COG2101
TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];
10-93 3.36e-10

TATA-box binding protein (TBP), component of TFIID and TFIIIB [Transcription];


Pssm-ID: 441704  Cd Length: 180  Bit Score: 57.13  E-value: 3.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046844362  10 DILITNVVCVFRTRCHLNLRKIA----LEGAN--------VIYKrdvgkvlmkLRKPRITATIWSSGKIICTGATSEEEA 77
Cdd:COG2101    94 EITVQNIVASADLGREINLNALAiglgLENIEyepeqfpgLVYR---------LDDPKVVLLLFSSGKLVITGAKDEEEA 164
                          90
                  ....*....|....*.
gi 1046844362  78 KFGARRLARSLQKLGF 93
Cdd:COG2101   165 ERAVDKLRERLEELGL 180
TBP_archaea cd04518
archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and ...
1-91 1.93e-09

archaeal TATA box binding protein (TBP): TBPs are transcription factors present in archaea and eukaryotes, that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation complexes: SL1, TFIID and TFIIIB, directing transcription by RNA polymerases I, II and III, respectively. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site. TBP's binding in the minor groove induces a dramatic DNA bending while its own structure barely changes. The conserved core domain of TBP, which binds to the TATA box, has a bipartite structure, with intramolecular symmetry generating a saddle-shaped structure that sits astride the DNA.


Pssm-ID: 239954  Cd Length: 174  Bit Score: 54.95  E-value: 1.93e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046844362   1 MDADSDVALDILITNVVCVFRTRCHLNLRKIALEGANVIYKRDV--GKVLmKLRKPRITATIWSSGKIICTGATSEEEAK 78
Cdd:cd04518    83 YGIKVIEKPEIKVQNIVASADLGREVNLDAIAIGLPNAEYEPEQfpGLVY-RLDEPKVVLLLFSSGKMVITGAKSEEDAK 161
                          90
                  ....*....|...
gi 1046844362  79 FGARRLARSLQKL 91
Cdd:cd04518   162 RAVEKLLSRLKEL 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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