Thrombospondin type 1 repeat; This is a thrombospondin type I repeat (TSR) found in properdin. Properdin, also known as factor P (fP), is a glycoprotein constructed from a common pool of structure units or modules, which are homologous to the thrombospondin type 1 repeat, TSR. It is positive regulator of the complement system that stabilizes the alternative pathway C3-convertase C3bBb. Properdin also inhibits the factor H-mediated cleavage of C3b by factor I. In addition, properdin acts as a pattern recognition molecule capable of identifying and interacting with microbial surfaces, apoptotic cells, and necrotic cells. However this role of pattern recognition is controversial. Studies indicate that this domain is a TSR variants. It is present at the N-terminal of properdin and has been denoted as TSR-0. It is suggested that the TSR-0 domain of properdin which possesses only the six Cys residues and no CWR-layered motif (which is usually found in other TSR domains) may constitute a truncated TSR domain.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1040696600  21 QMVQCFSAFSISTGKCADLLGE-IEKDFCCINPSYGFAEADGV-CRSCGH 68
Cdd:pfam18487   1 DPVLCFTQFEESSGKCKGLLGGgVSVEDCCLNPAYGFQEPGGGlCQSCRS 50

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1040696600   71 WSEWSSWSQCSVSCTEGVTQRRRFCYGNGNCSDPEDLG--TIQTKPCVKKDC 120
Cdd:smart00209   1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTgeDVETRACNEQPC 52

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1040696600  184 WSTWGNWGRCPVTCieeGRNTQkeVRTRTCTNPSPStaPPGRFCEGSEKDTRPCSGLPfCP 244
Cdd:smart00209   1 WSEWSEWSPCSVTC---GGGVQ--TRTRSCCSPPPQ--NGGGPCTGEDVETRACNEQP-CP 53

Thrombospondin type 1 repeat; This is a thrombospondin type I repeat (TSR) found in properdin. Properdin, also known as factor P (fP), is a glycoprotein constructed from a common pool of structure units or modules, which are homologous to the thrombospondin type 1 repeat, TSR. It is positive regulator of the complement system that stabilizes the alternative pathway C3-convertase C3bBb. Properdin also inhibits the factor H-mediated cleavage of C3b by factor I. In addition, properdin acts as a pattern recognition molecule capable of identifying and interacting with microbial surfaces, apoptotic cells, and necrotic cells. However this role of pattern recognition is controversial. Studies indicate that this domain is a TSR variants. It is present at the N-terminal of properdin and has been denoted as TSR-0. It is suggested that the TSR-0 domain of properdin which possesses only the six Cys residues and no CWR-layered motif (which is usually found in other TSR domains) may constitute a truncated TSR domain.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1040696600  21 QMVQCFSAFSISTGKCADLLGE-IEKDFCCINPSYGFAEADGV-CRSCGH 68
Cdd:pfam18487   1 DPVLCFTQFEESSGKCKGLLGGgVSVEDCCLNPAYGFQEPGGGlCQSCRS 50

Thrombospondin type 1 domain;

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1040696600 128 SKWGNWQPCSVTCENGQKKRQRACSNPAPkCGGSCSGEPQEIEPCSAD 175
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP-GGEPCTGDDIETQACKMD 47

Thrombospondin type 1 domain;

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1040696600  72 SEWSSWSQCSVSCTEGVTQRRRFCYGNGNCSDPEDLGTIQTKPCVKKDC 120
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFPGGEPCTGDDIETQACKMDKC 49

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1040696600  184 WSTWGNWGRCPVTCieeGRNTQkeVRTRTCTNPSPStaPPGRFCEGSEKDTRPCSGLPfCP 244
Cdd:smart00209   1 WSEWSEWSPCSVTC---GGGVQ--TRTRSCCSPPPQ--NGGGPCTGEDVETRACNEQP-CP 53

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1040696600  257 ACSVTCGVGRQMQSRICDSPSPKHGGKPCHGIEQKSGLCRTlAKCP 302
Cdd:smart00209   9 PCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNE-QPCP 53

Thrombospondin type 1 repeat; This is a thrombospondin type I repeat (TSR) found in properdin. Properdin, also known as factor P (fP), is a glycoprotein constructed from a common pool of structure units or modules, which are homologous to the thrombospondin type 1 repeat, TSR. It is positive regulator of the complement system that stabilizes the alternative pathway C3-convertase C3bBb. Properdin also inhibits the factor H-mediated cleavage of C3b by factor I. In addition, properdin acts as a pattern recognition molecule capable of identifying and interacting with microbial surfaces, apoptotic cells, and necrotic cells. However this role of pattern recognition is controversial. Studies indicate that this domain is a TSR variants. It is present at the N-terminal of properdin and has been denoted as TSR-0. It is suggested that the TSR-0 domain of properdin which possesses only the six Cys residues and no CWR-layered motif (which is usually found in other TSR domains) may constitute a truncated TSR domain.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1040696600  21 QMVQCFSAFSISTGKCADLLGE-IEKDFCCINPSYGFAEADGV-CRSCGH 68
Cdd:pfam18487   1 DPVLCFTQFEESSGKCKGLLGGgVSVEDCCLNPAYGFQEPGGGlCQSCRS 50

Thrombospondin type 1 domain;

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1040696600 128 SKWGNWQPCSVTCENGQKKRQRACSNPAPkCGGSCSGEPQEIEPCSAD 175
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP-GGEPCTGDDIETQACKMD 47

Thrombospondin type 1 domain;

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1040696600  72 SEWSSWSQCSVSCTEGVTQRRRFCYGNGNCSDPEDLGTIQTKPCVKKDC 120
Cdd:pfam00090   1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFPGGEPCTGDDIETQACKMDKC 49

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1040696600  184 WSTWGNWGRCPVTCieeGRNTQkeVRTRTCTNPSPStaPPGRFCEGSEKDTRPCSGLPfCP 244
Cdd:smart00209   1 WSEWSEWSPCSVTC---GGGVQ--TRTRSCCSPPPQ--NGGGPCTGEDVETRACNEQP-CP 53

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1040696600  257 ACSVTCGVGRQMQSRICDSPSPKHGGKPCHGIEQKSGLCRTlAKCP 302
Cdd:smart00209   9 PCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNE-QPCP 53

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.

                          10        20
                  ....*....|....*....|..
gi 1040696600  72 SEWSSWSQCSVSCTEGVTQRRR 93
Cdd:pfam19028   4 SEWSEWSECSVTCGGGVQTRTR 25