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Conserved domains on  [gi|1040675485|ref|XP_017208307|]
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bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1b isoform X1 [Danio rerio]

Protein Classification

bifunctional heparan sulfate N-deacetylase/N-sulfotransferase( domain architecture ID 10572471)

bifunctional heparan sulfate N-deacetylase/N-sulfotransferase catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HSNSD pfam12062
heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase ...
 92-519 0e+00

heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase enzymes. This protein is found in eukaryotes. This proteinenzyme is often found associated with pfam00685.


:

Pssm-ID: 463450  Cd Length: 429  Bit Score: 904.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040675485  92 TDPVVLVFVESLYSQLGQDIVAILESGRFRYQTEIApgKGDMPTLTDKNRGRFTLVIYENILKYVNLDAWNRELLDKYCV 171
Cdd:pfam12062   1 TDPKVLVFVESLYSQLGQEIIAILESNRFKYKTEIA--KKDLPVLTNKDKGRYSLIIYENYLKYLNMDKWNRELLDKYCR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040675485 172 EYGVGIIGFFKANENSLQSAQLKGFPLFLHSNLGLRDCSVNPKSPLLFITKAREVEHGPLPGDDWTVFQSNHTTYEPVLL 251
Cdd:pfam12062  79 EYGVGIIGFFKANENSLLSAQLKGFPLFLHTNLRLKDCTVNPKSPLLRITRPGEVEQGPLPGDDWTVFQSNHSTYEPVLL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040675485 252 ARGRSTEASGAPG---PLHAAVVQDLGLHDGIQRVLFGNNLNFWLHKLVLVDAVSFLTGKRLSLALERYILVDIDDIFVG 328
Cdd:pfam12062 159 AKVKSGEESPSPGldaALLATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFLDALSYLTGKRLSLSLDRYILVDIDDIFVG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040675485 329 KEGTRMKVSDVKALLETQNELRNHVPNFTFNLGFSGKFFHAGTDEEDLGDDLLLSYSKEFWWFPHMWSHMQPHLFHNQSV 408
Cdd:pfam12062 239 KEGTRMKVEDVKALLETQNRLRTLVPNFTFNLGFSGKYFHNGTDEEDEGDDLLLENVKEFWWFPHMWSHMQPHLFHNQTV 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040675485 409 LAEQMLLNHKFAEEHGIPTNMGYAVAPHHSGVYPIHLQLYEAWKKVWGIKVTSTEEYPHLKPARFRRGFVHSGISVLPRQ 488
Cdd:pfam12062 319 LEEQMLLNKKFAQEHGIPTDSGYAVAPHHSGVYPVHEQLYEAWKKVWNIKVTSTEEYPHLKPARLRRGFIHRGIMVLPRQ 398

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1040675485 489 TCGLFTHTIFYNEYPGGSKELDKLIYGGELF 519
Cdd:pfam12062 399 TCGLFTHTIFYDEYPGGPKKLDKSIQGGELF 429
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
609-859 2.59e-43

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 157.89  E-value: 2.59e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040675485 609 PKLLIIGPQKTGTTALYLFLSMHSDLTSNypskETFEEIQFFNGRNYHKGIDWY-------MEHFPLPSNTSSDFYFEKS 681
Cdd:pfam00685   2 DDVLIVTYPKSGTTWLQEILSLIPNRGDF----EKSEEPHLFNNHNRSPFLEWYpgdtyfdVAEGPVRLNALPSPRIIKT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040675485 682 ANYFDSevaaRRAAALLPKAKIITILINPADRAYSWYQHQRAHDDPVAQKYTFHDVITagrdapiklrvLQSRCLVPGLY 761
Cdd:pfam00685  78 HLPLHL----LPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVED-----------FLNGKVNCGSY 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040675485 762 ATHLQRWLTHYHPSQILVLDGQMLRTEPASVMDKIQKFLGLINT----LNYHKILAFDPKKGFWCQLL-------DGGKT 830
Cdd:pfam00685 143 FDHVKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTeeelDKIVKHLSFENMKGNPCLNYsklpkevSPFFR 222

                         250       260
                  ....*....|....*....|....*....
gi 1040675485 831 KCLGKSKgrrYPDMDVDSRTFLREYYHEH 859
Cdd:pfam00685 223 KGLVGDW---KNYFTPEQAEKFDEIYQEK 248
 
Name Accession Description Interval E-value
HSNSD pfam12062
heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase ...
 92-519 0e+00

heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase enzymes. This protein is found in eukaryotes. This proteinenzyme is often found associated with pfam00685.


Pssm-ID: 463450  Cd Length: 429  Bit Score: 904.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040675485  92 TDPVVLVFVESLYSQLGQDIVAILESGRFRYQTEIApgKGDMPTLTDKNRGRFTLVIYENILKYVNLDAWNRELLDKYCV 171
Cdd:pfam12062   1 TDPKVLVFVESLYSQLGQEIIAILESNRFKYKTEIA--KKDLPVLTNKDKGRYSLIIYENYLKYLNMDKWNRELLDKYCR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040675485 172 EYGVGIIGFFKANENSLQSAQLKGFPLFLHSNLGLRDCSVNPKSPLLFITKAREVEHGPLPGDDWTVFQSNHTTYEPVLL 251
Cdd:pfam12062  79 EYGVGIIGFFKANENSLLSAQLKGFPLFLHTNLRLKDCTVNPKSPLLRITRPGEVEQGPLPGDDWTVFQSNHSTYEPVLL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040675485 252 ARGRSTEASGAPG---PLHAAVVQDLGLHDGIQRVLFGNNLNFWLHKLVLVDAVSFLTGKRLSLALERYILVDIDDIFVG 328
Cdd:pfam12062 159 AKVKSGEESPSPGldaALLATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFLDALSYLTGKRLSLSLDRYILVDIDDIFVG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040675485 329 KEGTRMKVSDVKALLETQNELRNHVPNFTFNLGFSGKFFHAGTDEEDLGDDLLLSYSKEFWWFPHMWSHMQPHLFHNQSV 408
Cdd:pfam12062 239 KEGTRMKVEDVKALLETQNRLRTLVPNFTFNLGFSGKYFHNGTDEEDEGDDLLLENVKEFWWFPHMWSHMQPHLFHNQTV 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040675485 409 LAEQMLLNHKFAEEHGIPTNMGYAVAPHHSGVYPIHLQLYEAWKKVWGIKVTSTEEYPHLKPARFRRGFVHSGISVLPRQ 488
Cdd:pfam12062 319 LEEQMLLNKKFAQEHGIPTDSGYAVAPHHSGVYPVHEQLYEAWKKVWNIKVTSTEEYPHLKPARLRRGFIHRGIMVLPRQ 398

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1040675485 489 TCGLFTHTIFYNEYPGGSKELDKLIYGGELF 519
Cdd:pfam12062 399 TCGLFTHTIFYDEYPGGPKKLDKSIQGGELF 429
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
609-859 2.59e-43

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 157.89  E-value: 2.59e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040675485 609 PKLLIIGPQKTGTTALYLFLSMHSDLTSNypskETFEEIQFFNGRNYHKGIDWY-------MEHFPLPSNTSSDFYFEKS 681
Cdd:pfam00685   2 DDVLIVTYPKSGTTWLQEILSLIPNRGDF----EKSEEPHLFNNHNRSPFLEWYpgdtyfdVAEGPVRLNALPSPRIIKT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040675485 682 ANYFDSevaaRRAAALLPKAKIITILINPADRAYSWYQHQRAHDDPVAQKYTFHDVITagrdapiklrvLQSRCLVPGLY 761
Cdd:pfam00685  78 HLPLHL----LPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVED-----------FLNGKVNCGSY 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040675485 762 ATHLQRWLTHYHPSQILVLDGQMLRTEPASVMDKIQKFLGLINT----LNYHKILAFDPKKGFWCQLL-------DGGKT 830
Cdd:pfam00685 143 FDHVKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTeeelDKIVKHLSFENMKGNPCLNYsklpkevSPFFR 222

                         250       260
                  ....*....|....*....|....*....
gi 1040675485 831 KCLGKSKgrrYPDMDVDSRTFLREYYHEH 859
Cdd:pfam00685 223 KGLVGDW---KNYFTPEQAEKFDEIYQEK 248
 
Name Accession Description Interval E-value
HSNSD pfam12062
heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase ...
 92-519 0e+00

heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase enzymes. This protein is found in eukaryotes. This proteinenzyme is often found associated with pfam00685.


Pssm-ID: 463450  Cd Length: 429  Bit Score: 904.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040675485  92 TDPVVLVFVESLYSQLGQDIVAILESGRFRYQTEIApgKGDMPTLTDKNRGRFTLVIYENILKYVNLDAWNRELLDKYCV 171
Cdd:pfam12062   1 TDPKVLVFVESLYSQLGQEIIAILESNRFKYKTEIA--KKDLPVLTNKDKGRYSLIIYENYLKYLNMDKWNRELLDKYCR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040675485 172 EYGVGIIGFFKANENSLQSAQLKGFPLFLHSNLGLRDCSVNPKSPLLFITKAREVEHGPLPGDDWTVFQSNHTTYEPVLL 251
Cdd:pfam12062  79 EYGVGIIGFFKANENSLLSAQLKGFPLFLHTNLRLKDCTVNPKSPLLRITRPGEVEQGPLPGDDWTVFQSNHSTYEPVLL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040675485 252 ARGRSTEASGAPG---PLHAAVVQDLGLHDGIQRVLFGNNLNFWLHKLVLVDAVSFLTGKRLSLALERYILVDIDDIFVG 328
Cdd:pfam12062 159 AKVKSGEESPSPGldaALLATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFLDALSYLTGKRLSLSLDRYILVDIDDIFVG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040675485 329 KEGTRMKVSDVKALLETQNELRNHVPNFTFNLGFSGKFFHAGTDEEDLGDDLLLSYSKEFWWFPHMWSHMQPHLFHNQSV 408
Cdd:pfam12062 239 KEGTRMKVEDVKALLETQNRLRTLVPNFTFNLGFSGKYFHNGTDEEDEGDDLLLENVKEFWWFPHMWSHMQPHLFHNQTV 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040675485 409 LAEQMLLNHKFAEEHGIPTNMGYAVAPHHSGVYPIHLQLYEAWKKVWGIKVTSTEEYPHLKPARFRRGFVHSGISVLPRQ 488
Cdd:pfam12062 319 LEEQMLLNKKFAQEHGIPTDSGYAVAPHHSGVYPVHEQLYEAWKKVWNIKVTSTEEYPHLKPARLRRGFIHRGIMVLPRQ 398

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1040675485 489 TCGLFTHTIFYNEYPGGSKELDKLIYGGELF 519
Cdd:pfam12062 399 TCGLFTHTIFYDEYPGGPKKLDKSIQGGELF 429
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
609-859 2.59e-43

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 157.89  E-value: 2.59e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040675485 609 PKLLIIGPQKTGTTALYLFLSMHSDLTSNypskETFEEIQFFNGRNYHKGIDWY-------MEHFPLPSNTSSDFYFEKS 681
Cdd:pfam00685   2 DDVLIVTYPKSGTTWLQEILSLIPNRGDF----EKSEEPHLFNNHNRSPFLEWYpgdtyfdVAEGPVRLNALPSPRIIKT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040675485 682 ANYFDSevaaRRAAALLPKAKIITILINPADRAYSWYQHQRAHDDPVAQKYTFHDVITagrdapiklrvLQSRCLVPGLY 761
Cdd:pfam00685  78 HLPLHL----LPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVED-----------FLNGKVNCGSY 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040675485 762 ATHLQRWLTHYHPSQILVLDGQMLRTEPASVMDKIQKFLGLINT----LNYHKILAFDPKKGFWCQLL-------DGGKT 830
Cdd:pfam00685 143 FDHVKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTeeelDKIVKHLSFENMKGNPCLNYsklpkevSPFFR 222

                         250       260
                  ....*....|....*....|....*....
gi 1040675485 831 KCLGKSKgrrYPDMDVDSRTFLREYYHEH 859
Cdd:pfam00685 223 KGLVGDW---KNYFTPEQAEKFDEIYQEK 248
Sulfotransfer_3 pfam13469
Sulfotransferase family;
611-802 2.35e-10

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 60.38  E-value: 2.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040675485 611 LLIIGPQKTGTTALYLFLSMHSDLTSNYpskETFEEIQFFNGRnYHKGIDWYMEHFPLPSNTssDFYFEKSANYFDSeva 690
Cdd:pfam13469   1 IFIVGLPRSGTTLLHRLLAAHPDVRPPE---ETWFVIPRILAL-LQAWGKSLEALARVPSYA--RWLCDKSPSHLFH--- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040675485 691 ARRAAALLPKAKIITILINPADRAYSWYQHQRAHDdpvAQKYTFHDVITAGRDAPiklrvlqsrclvpgLYATHLQRWLT 770
Cdd:pfam13469  72 LDLLLKAFPDAKFIHLHRDPVDTVISSYCSLFGFT---LSSYSTAFLRDIGLALA--------------RWSRAYERLMA 134

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1040675485 771 HYH---PSQILVLDGQMLRTEPASVMDKIQKFLGL 802
Cdd:pfam13469 135 ARArvpPGRFLDVRYEDLVADPEGTLRRILEFLGL 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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