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Conserved domains on  [gi|1039778028|ref|XP_017177616|]
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vomeronasal 2, receptor, 14 isoform X1 [Mus musculus]

Protein Classification

vomeronasal type-2 receptor( domain architecture ID 11570779)

vomeronasal type-2 receptor is a G-protein coupled receptor (GPCR) that is involved in detecting protein pheromones for social and sexual cues between the same species; GPCRs transmit physiological signals from the outside of the cell to the inside via G proteins by binding to an extracellular agonist, which induces conformational changes that lead to the activation of heterotrimeric G proteins, which then bind to and activate numerous downstream effector proteins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PBP1_pheromone_receptor cd06365
Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within ...
43-503 9.48e-155

Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily, which also includes the metabotropic glutamate receptor, the GABAb receptor, the calcium-sensing receptor (CaSR), the T1R taste receptor, and a small group of uncharacterized orphan receptors.


:

Pssm-ID: 380588 [Multi-domain]  Cd Length: 464  Bit Score: 460.96  E-value: 9.48e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028  43 CAFILAAVQTPIENDY---FNKTLNVLKTTKNHKYALALVFAMDEINRNPDLLPNMSLIIRYTLGRCDGKTVIPTPYLFR 119
Cdd:cd06365     4 GVFPIHTFSEGKKKDFkepPSPLLCFRFSIKYYQHLLAFLFAIEEINKNPDLLPNITLGFHIYDSCSSERLALESSLSIL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 120 KKKESPIPNYFCNEETMCSYLLTGPHWEVSLGfwkhMNSFLS-PRILQLTYGPFHSIFSDDEQYPYLYQMAPKDTSLALA 198
Cdd:cd06365    84 SGNSEPIPNYSCREQRKLVAFIGDLSSSTSVA----MARILGlYKYPQISYGAFDPLLSDKVQFPSFYRTVPSDTSQSLA 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 199 MVSFILYFSWNWIGLVIPDDDQGNQFLLELKKQSENKEICFAFVKMISVDDVSFpqNTEMYYNQIVMSSTNVIIIYGETY 278
Cdd:cd06365   160 IVQLLKHFGWTWVGLIISDDDYGEQFSQDLKKEMEKNGICVAFVEKIPTNSSLK--RIIKYINQIIKSSANVIIIYGDTD 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 279 NFIDLIFRMWEPPILQRIWITTKQLNFPTRKKDISHGTFYGSLTFLPHHGVISGFKNFVQTwFHLRNT--DLYLVMQEWK 356
Cdd:cd06365   238 SLLELLFRLWEQLVTGKVWITTSQWDISTLPFEFYLNLFNGTLGFSQHSGEIPGFKEFLQS-VHPSKYpeDIFLKTLWES 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 357 YFNYEDSASTCKILKNNSSNASFDWLMEQKFDMTFSENSHNIYNAVHAIAHALHEMNLQQADNQAIDNGKGASSHCLKVN 436
Cdd:cd06365   317 YFNCKWPDQNCKSLQNCCGNESLETLDVHSFDMTMSRLSYNVYNAVYAVAHALHEMLLCQPKTGPGNCSDRRNFQPWQLH 396
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039778028 437 SFLRRIYFTNPPGDKVFMKQRVIMHDEYDIVHFVNLSQHLGIKMKLGKFSPYLPHGRHSHLYVDRIE 503
Cdd:cd06365   397 HYLKKVQFTNPAGDEVNFDEKGDLPTKYDILNWQIFPNGTGTKVKVGTFDPSAPSGQQLIINDSMIE 463
7tmC_V2R_pheromone cd15283
vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G ...
585-836 1.29e-142

vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors; This group represents vomeronasal type-2 pheromone receptors (V2Rs). Members of the V2R family of vomeronasal GPCRs are involved in detecting protein pheromones for social and sexual cues between the same species. V2Rs and G-alpha(o) protein are coexpressed in the basal layer of the vomeronasal organ (VNO), which is the sensory organ of the accessory olfactory system present in amphibians, reptiles, and non-primate mammals such as mice and rodents, but it is non-functional or absent in humans, apes, and monkeys. On the other hand, members of the V1R receptor family and G-alpha(i2) protein are coexpressed in the apical neurons of the VNO. Activation of V1R or V2R causes activation of phospholipase pathway, producing the second messengers diacylglycerol (DAG) and IP3. However, in contrast to V1Rs, V2Rs contain the long N-terminal extracellular domain, which is believed to bind pheromones.


:

Pssm-ID: 320410 [Multi-domain]  Cd Length: 252  Bit Score: 421.69  E-value: 1.29e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 585 PLGMALALMAFCFSAFTAVVLCVFVKHHDTPIVKANNRSLSYLLLMSLMSCFLCSFFFIGLPNRAICVLQQITFGIVFTM 664
Cdd:cd15283     1 PLGIALTVLSLLGSVLTAAVLVVFIKHRDTPIVKANNSELSYLLLLSLKLCFLCSLLFIGQPSTWTCMLRQTAFGISFVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 665 AVSTVLAKTVTVVLAFKVTDPGRRLRNFLVSGTPNYIIPICSLLQCVLCAIWLAVSPPFVDIDEHTLHGHIIIVCNKGSV 744
Cdd:cd15283    81 CISCILAKTIVVVAAFKATRPGSNIMKWFGPGQQRAIIFICTLVQVVICAIWLATSPPFPDKNMHSEHGKIILECNEGSV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 745 TAFYCILGYLACLALGNFSVAFLAKNLPDTFNEAKFLTFSMLVFCSVWVTFLPVYHSTKGKHMVAVEIFSILASSAGILG 824
Cdd:cd15283   161 VAFYCVLGYIGLLALVSFLLAFLARKLPDNFNEAKFITFSMLVFCAVWVAFVPAYISSPGKYMVAVEIFAILASSAGLLG 240
                         250
                  ....*....|..
gi 1039778028 825 CIFVPKIYIILM 836
Cdd:cd15283   241 CIFAPKCYIILL 252
NCD3G pfam07562
Nine Cysteines Domain of family 3 GPCR; This conserved sequence contains several ...
512-565 3.83e-23

Nine Cysteines Domain of family 3 GPCR; This conserved sequence contains several highly-conserved Cys residues that are predicted to form disulphide bridges. It is predicted to lie outside the cell membrane, tethered to the pfam00003 in several receptor proteins.


:

Pssm-ID: 462210  Cd Length: 53  Bit Score: 93.09  E-value: 3.83e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1039778028 512 PSSVCSADCSPGFRRLWKEGMAACCFVCSPCPENEISNeTNMDQCVNCPEYQYA 565
Cdd:pfam07562   1 PSSVCSESCPPGQRKSQQGGAPVCCWDCVPCPEGEISN-TDSDTCKKCPEGQWP 53
 
Name Accession Description Interval E-value
PBP1_pheromone_receptor cd06365
Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within ...
43-503 9.48e-155

Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily, which also includes the metabotropic glutamate receptor, the GABAb receptor, the calcium-sensing receptor (CaSR), the T1R taste receptor, and a small group of uncharacterized orphan receptors.


Pssm-ID: 380588 [Multi-domain]  Cd Length: 464  Bit Score: 460.96  E-value: 9.48e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028  43 CAFILAAVQTPIENDY---FNKTLNVLKTTKNHKYALALVFAMDEINRNPDLLPNMSLIIRYTLGRCDGKTVIPTPYLFR 119
Cdd:cd06365     4 GVFPIHTFSEGKKKDFkepPSPLLCFRFSIKYYQHLLAFLFAIEEINKNPDLLPNITLGFHIYDSCSSERLALESSLSIL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 120 KKKESPIPNYFCNEETMCSYLLTGPHWEVSLGfwkhMNSFLS-PRILQLTYGPFHSIFSDDEQYPYLYQMAPKDTSLALA 198
Cdd:cd06365    84 SGNSEPIPNYSCREQRKLVAFIGDLSSSTSVA----MARILGlYKYPQISYGAFDPLLSDKVQFPSFYRTVPSDTSQSLA 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 199 MVSFILYFSWNWIGLVIPDDDQGNQFLLELKKQSENKEICFAFVKMISVDDVSFpqNTEMYYNQIVMSSTNVIIIYGETY 278
Cdd:cd06365   160 IVQLLKHFGWTWVGLIISDDDYGEQFSQDLKKEMEKNGICVAFVEKIPTNSSLK--RIIKYINQIIKSSANVIIIYGDTD 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 279 NFIDLIFRMWEPPILQRIWITTKQLNFPTRKKDISHGTFYGSLTFLPHHGVISGFKNFVQTwFHLRNT--DLYLVMQEWK 356
Cdd:cd06365   238 SLLELLFRLWEQLVTGKVWITTSQWDISTLPFEFYLNLFNGTLGFSQHSGEIPGFKEFLQS-VHPSKYpeDIFLKTLWES 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 357 YFNYEDSASTCKILKNNSSNASFDWLMEQKFDMTFSENSHNIYNAVHAIAHALHEMNLQQADNQAIDNGKGASSHCLKVN 436
Cdd:cd06365   317 YFNCKWPDQNCKSLQNCCGNESLETLDVHSFDMTMSRLSYNVYNAVYAVAHALHEMLLCQPKTGPGNCSDRRNFQPWQLH 396
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039778028 437 SFLRRIYFTNPPGDKVFMKQRVIMHDEYDIVHFVNLSQHLGIKMKLGKFSPYLPHGRHSHLYVDRIE 503
Cdd:cd06365   397 HYLKKVQFTNPAGDEVNFDEKGDLPTKYDILNWQIFPNGTGTKVKVGTFDPSAPSGQQLIINDSMIE 463
7tmC_V2R_pheromone cd15283
vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G ...
585-836 1.29e-142

vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors; This group represents vomeronasal type-2 pheromone receptors (V2Rs). Members of the V2R family of vomeronasal GPCRs are involved in detecting protein pheromones for social and sexual cues between the same species. V2Rs and G-alpha(o) protein are coexpressed in the basal layer of the vomeronasal organ (VNO), which is the sensory organ of the accessory olfactory system present in amphibians, reptiles, and non-primate mammals such as mice and rodents, but it is non-functional or absent in humans, apes, and monkeys. On the other hand, members of the V1R receptor family and G-alpha(i2) protein are coexpressed in the apical neurons of the VNO. Activation of V1R or V2R causes activation of phospholipase pathway, producing the second messengers diacylglycerol (DAG) and IP3. However, in contrast to V1Rs, V2Rs contain the long N-terminal extracellular domain, which is believed to bind pheromones.


Pssm-ID: 320410 [Multi-domain]  Cd Length: 252  Bit Score: 421.69  E-value: 1.29e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 585 PLGMALALMAFCFSAFTAVVLCVFVKHHDTPIVKANNRSLSYLLLMSLMSCFLCSFFFIGLPNRAICVLQQITFGIVFTM 664
Cdd:cd15283     1 PLGIALTVLSLLGSVLTAAVLVVFIKHRDTPIVKANNSELSYLLLLSLKLCFLCSLLFIGQPSTWTCMLRQTAFGISFVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 665 AVSTVLAKTVTVVLAFKVTDPGRRLRNFLVSGTPNYIIPICSLLQCVLCAIWLAVSPPFVDIDEHTLHGHIIIVCNKGSV 744
Cdd:cd15283    81 CISCILAKTIVVVAAFKATRPGSNIMKWFGPGQQRAIIFICTLVQVVICAIWLATSPPFPDKNMHSEHGKIILECNEGSV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 745 TAFYCILGYLACLALGNFSVAFLAKNLPDTFNEAKFLTFSMLVFCSVWVTFLPVYHSTKGKHMVAVEIFSILASSAGILG 824
Cdd:cd15283   161 VAFYCVLGYIGLLALVSFLLAFLARKLPDNFNEAKFITFSMLVFCAVWVAFVPAYISSPGKYMVAVEIFAILASSAGLLG 240
                         250
                  ....*....|..
gi 1039778028 825 CIFVPKIYIILM 836
Cdd:cd15283   241 CIFAPKCYIILL 252
7tm_3 pfam00003
7 transmembrane sweet-taste receptor of 3 GCPR; This is a domain of seven transmembrane ...
580-830 2.92e-73

7 transmembrane sweet-taste receptor of 3 GCPR; This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G pfam07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor pfam01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness.


Pssm-ID: 459626 [Multi-domain]  Cd Length: 247  Bit Score: 240.25  E-value: 2.92e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 580 LSYEDPLGMALALMAFCFSAFTAVVLCVFVKHHDTPIVKANNRSLSYLLLMSLMSCFLCSFFFIGLPNrAICVLQQITFG 659
Cdd:pfam00003   1 LDLSAPWGIVLEALAALGILLTLVLLVVFLLHRKTPIVKASNRSLSFLLLLGLLLLFLLAFLFIGKPT-VTCALRRFLFG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 660 IVFTMAVSTVLAKTVTVVLAFKVTDPGRRLRNFLVsgtpnyIIPICSLLQCVLCAIWLAVsPPFVDIDEHTlHGHIIIVC 739
Cdd:pfam00003  80 VGFTLCFSCLLAKTFRLVLIFRRRKPGPRGWQLLL------LALGLLLVQVIILTEWLID-PPFPEKDNLS-EGKIILEC 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 740 NKGSVTAF-YCILGYLACLALGNFSVAFLAKNLPDTFNEAKFLTFSMLVFCSVWVTFLPVY-HSTKGKHM---VAVEIFS 814
Cdd:pfam00003 152 EGSTSIAFlDFVLAYVGLLLLAGFLLAFKTRKLPDNFNEAKFITFSMLLSVLIWVAFIPMYlYGNKGKGTwdpVALAIFA 231
                         250
                  ....*....|....*.
gi 1039778028 815 ILASSAGILGCIFVPK 830
Cdd:pfam00003 232 ILASGWVLLGLYFIPK 247
NCD3G pfam07562
Nine Cysteines Domain of family 3 GPCR; This conserved sequence contains several ...
512-565 3.83e-23

Nine Cysteines Domain of family 3 GPCR; This conserved sequence contains several highly-conserved Cys residues that are predicted to form disulphide bridges. It is predicted to lie outside the cell membrane, tethered to the pfam00003 in several receptor proteins.


Pssm-ID: 462210  Cd Length: 53  Bit Score: 93.09  E-value: 3.83e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1039778028 512 PSSVCSADCSPGFRRLWKEGMAACCFVCSPCPENEISNeTNMDQCVNCPEYQYA 565
Cdd:pfam07562   1 PSSVCSESCPPGQRKSQQGGAPVCCWDCVPCPEGEISN-TDSDTCKKCPEGQWP 53
ANF_receptor pfam01094
Receptor family ligand binding region; This family includes extracellular ligand binding ...
75-423 3.78e-18

Receptor family ligand binding region; This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure.


Pssm-ID: 460062 [Multi-domain]  Cd Length: 347  Bit Score: 86.67  E-value: 3.78e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028  75 ALALVFAMDEINRNPDLLPN--MSLIIRYTlgRCDGKTVIPTPYLFRKKKESPIPNYFCNEE-TMCSYLLTgpHWEVSlg 151
Cdd:pfam01094   3 LLAVRLAVEDINADPGLLPGtkLEYIILDT--CCDPSLALAAALDLLKGEVVAIIGPSCSSVaSAVASLAN--EWKVP-- 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 152 fwkhmnsflsprilQLTYGPFHSIFSDDEQYPYLYQMAPKDTSLALAMVSFILYFSWNWIGLVIPDDDQGNQFLLELKKQ 231
Cdd:pfam01094  77 --------------LISYGSTSPALSDLNRYPTFLRTTPSDTSQADAIVDILKHFGWKRVALIYSDDDYGESGLQALEDA 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 232 SENKEICFAFVKMISVDDvSFPQNTEMYYNQIVMSSTnVIII--YGET-YNFIDLI--------FRMWeppILQRIWITT 300
Cdd:pfam01094 143 LRERGIRVAYKAVIPPAQ-DDDEIARKLLKEVKSRAR-VIVVccSSETaRRLLKAArelgmmgeGYVW---IATDGLTTS 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 301 KQLNFPTRKKdishgTFYGSLTFLPHHGVISGFKNFVQTWFHLRNTDLylvmqewkyfnyedsastckilknnssnasfd 380
Cdd:pfam01094 218 LVILNPSTLE-----AAGGVLGFRLHPPDSPEFSEFFWEKLSDEKELY-------------------------------- 260
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1039778028 381 wLMEQKFDMTFSEnshNIYNAVHAIAHALHEMNLQQADNQAID 423
Cdd:pfam01094 261 -ENLGGLPVSYGA---LAYDAVYLLAHALHNLLRDDKPGRACG 299
 
Name Accession Description Interval E-value
PBP1_pheromone_receptor cd06365
Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within ...
43-503 9.48e-155

Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily, which also includes the metabotropic glutamate receptor, the GABAb receptor, the calcium-sensing receptor (CaSR), the T1R taste receptor, and a small group of uncharacterized orphan receptors.


Pssm-ID: 380588 [Multi-domain]  Cd Length: 464  Bit Score: 460.96  E-value: 9.48e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028  43 CAFILAAVQTPIENDY---FNKTLNVLKTTKNHKYALALVFAMDEINRNPDLLPNMSLIIRYTLGRCDGKTVIPTPYLFR 119
Cdd:cd06365     4 GVFPIHTFSEGKKKDFkepPSPLLCFRFSIKYYQHLLAFLFAIEEINKNPDLLPNITLGFHIYDSCSSERLALESSLSIL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 120 KKKESPIPNYFCNEETMCSYLLTGPHWEVSLGfwkhMNSFLS-PRILQLTYGPFHSIFSDDEQYPYLYQMAPKDTSLALA 198
Cdd:cd06365    84 SGNSEPIPNYSCREQRKLVAFIGDLSSSTSVA----MARILGlYKYPQISYGAFDPLLSDKVQFPSFYRTVPSDTSQSLA 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 199 MVSFILYFSWNWIGLVIPDDDQGNQFLLELKKQSENKEICFAFVKMISVDDVSFpqNTEMYYNQIVMSSTNVIIIYGETY 278
Cdd:cd06365   160 IVQLLKHFGWTWVGLIISDDDYGEQFSQDLKKEMEKNGICVAFVEKIPTNSSLK--RIIKYINQIIKSSANVIIIYGDTD 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 279 NFIDLIFRMWEPPILQRIWITTKQLNFPTRKKDISHGTFYGSLTFLPHHGVISGFKNFVQTwFHLRNT--DLYLVMQEWK 356
Cdd:cd06365   238 SLLELLFRLWEQLVTGKVWITTSQWDISTLPFEFYLNLFNGTLGFSQHSGEIPGFKEFLQS-VHPSKYpeDIFLKTLWES 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 357 YFNYEDSASTCKILKNNSSNASFDWLMEQKFDMTFSENSHNIYNAVHAIAHALHEMNLQQADNQAIDNGKGASSHCLKVN 436
Cdd:cd06365   317 YFNCKWPDQNCKSLQNCCGNESLETLDVHSFDMTMSRLSYNVYNAVYAVAHALHEMLLCQPKTGPGNCSDRRNFQPWQLH 396
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039778028 437 SFLRRIYFTNPPGDKVFMKQRVIMHDEYDIVHFVNLSQHLGIKMKLGKFSPYLPHGRHSHLYVDRIE 503
Cdd:cd06365   397 HYLKKVQFTNPAGDEVNFDEKGDLPTKYDILNWQIFPNGTGTKVKVGTFDPSAPSGQQLIINDSMIE 463
7tmC_V2R_pheromone cd15283
vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G ...
585-836 1.29e-142

vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors; This group represents vomeronasal type-2 pheromone receptors (V2Rs). Members of the V2R family of vomeronasal GPCRs are involved in detecting protein pheromones for social and sexual cues between the same species. V2Rs and G-alpha(o) protein are coexpressed in the basal layer of the vomeronasal organ (VNO), which is the sensory organ of the accessory olfactory system present in amphibians, reptiles, and non-primate mammals such as mice and rodents, but it is non-functional or absent in humans, apes, and monkeys. On the other hand, members of the V1R receptor family and G-alpha(i2) protein are coexpressed in the apical neurons of the VNO. Activation of V1R or V2R causes activation of phospholipase pathway, producing the second messengers diacylglycerol (DAG) and IP3. However, in contrast to V1Rs, V2Rs contain the long N-terminal extracellular domain, which is believed to bind pheromones.


Pssm-ID: 320410 [Multi-domain]  Cd Length: 252  Bit Score: 421.69  E-value: 1.29e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 585 PLGMALALMAFCFSAFTAVVLCVFVKHHDTPIVKANNRSLSYLLLMSLMSCFLCSFFFIGLPNRAICVLQQITFGIVFTM 664
Cdd:cd15283     1 PLGIALTVLSLLGSVLTAAVLVVFIKHRDTPIVKANNSELSYLLLLSLKLCFLCSLLFIGQPSTWTCMLRQTAFGISFVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 665 AVSTVLAKTVTVVLAFKVTDPGRRLRNFLVSGTPNYIIPICSLLQCVLCAIWLAVSPPFVDIDEHTLHGHIIIVCNKGSV 744
Cdd:cd15283    81 CISCILAKTIVVVAAFKATRPGSNIMKWFGPGQQRAIIFICTLVQVVICAIWLATSPPFPDKNMHSEHGKIILECNEGSV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 745 TAFYCILGYLACLALGNFSVAFLAKNLPDTFNEAKFLTFSMLVFCSVWVTFLPVYHSTKGKHMVAVEIFSILASSAGILG 824
Cdd:cd15283   161 VAFYCVLGYIGLLALVSFLLAFLARKLPDNFNEAKFITFSMLVFCAVWVAFVPAYISSPGKYMVAVEIFAILASSAGLLG 240
                         250
                  ....*....|..
gi 1039778028 825 CIFVPKIYIILM 836
Cdd:cd15283   241 CIFAPKCYIILL 252
7tmC_V2R_AA_sensing_receptor-like cd15044
vomeronasal type-2 pheromone receptors, amino acid-sensing receptors and closely related ...
585-836 1.40e-80

vomeronasal type-2 pheromone receptors, amino acid-sensing receptors and closely related proteins; member of the class C family of seven-transmembrane G protein-coupled receptors; This group is composed of vomeronasal type-2 pheromone receptors (V2Rs), a subgroup of broad-spectrum amino-acid sensing receptors including calcium-sensing receptor (CaSR) and GPRC6A, as well as their closely related proteins. Members of the V2R family of vomeronasal GPCRs are involved in detecting protein pheromones for social and sexual cues between the same species. V2Rs and G-alpha(o) protein are co-expressed in the basal layer of the vomeronasal organ (VNO), which is the sensory organ of the accessory olfactory system present in amphibians, reptiles, and non-primate mammals such as mice and rodents, but it is non-functional or absent in humans, apes, and monkeys. On the other hand, members of the V1R receptor family and G-alpha(i2) protein are co-expressed in the apical neurons of the VNO. Activation of V1R or V2R causes activation of phospholipase pathway, producing the second messengers diacylglycerol (DAG) and IP3. However, in contrast to V1Rs, V2Rs contain the long N-terminal extracellular domain, which is believed to bind pheromones. CaSR is a widely expressed GPCR that is involved in sensing small changes in extracellular levels of calcium ion to maintain a constant level of the extracellular calcium via modulating the synthesis and secretion of calcium regulating hormones, such as parathyroid hormone (PTH), in order to regulate Ca(2+)transport into or out of the extracellular fluid via kidney, intestine, and/or bone. For instance, when Ca2+ is high, CaSR downregulates PTH synthesis and secretion, leading to an increase in renal Ca2+ excretion, a decrease in intestinal Ca2+ absorption, and a reduction in release of skeletal Ca2+. GRPC6A (GPCR, class C, group 6, subtype A) is a widely expressed amino acid-sensing GPCR that is most closely related to CaSR. GPRC6A is most potently activated by the basic amino acids L-arginine, L-lysine, and L-ornithine and less potently by small aliphatic amino acids. Moreover, the receptor can be either activated or modulated by divalent cations such as Ca2+. GPRC6A is expressed in the testis, but not the ovary and specifically also binds to the osteoblast-derived hormone osteocalcin (OCN), which regulates testosterone production by the testis and male fertility independently of the hypothalamic-pituitary axis. Furthermore, GPRC6A knockout studies suggest that GRPC6A is involved in regulation of bone metabolism, male reproduction, energy homeostasis, glucose metabolism, and in activation of inflammation response, as well as prostate cancer growth and progression, among others.


Pssm-ID: 320172 [Multi-domain]  Cd Length: 251  Bit Score: 259.71  E-value: 1.40e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 585 PLGMALALMAFCFSAFTAVVLCVFVKHHDTPIVKANNRSLSYLLLMSLMSCFLCSFFFIGLPNRAICVLQQITFGIVFTM 664
Cdd:cd15044     1 PLGILLVILSILGIIFVLVVGGVFVRYRNTPIVKANNRELSYLILLSLFLCFSSSLFFIGEPQDWTCKLRQTMFGVSFTL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 665 AVSTVLAKTVTVVLAFKVTDPGRRlRNFLVSGTPNYIIPICSLLQCVLCAIWLAVSPPFVDIDEHTLHGHIIIVCNKGSV 744
Cdd:cd15044    81 CISCILTKTLKVLLAFSADKPLTQ-KFLMCLYLPILIVFTCTGIQVVICTVWLIFAPPTVEVNVSPLPRVIILECNEGSI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 745 TAFYCILGYLACLALGNFSVAFLAKNLPDTFNEAKFLTFSMLVFCSVWVTFLPVYHSTKGKHMVAVEIFSILASSAGILG 824
Cdd:cd15044   160 LAFGTMLGYIAFLAFLCFLFAFKARKLPDNYNEAKFITFGMLVFFIVWISFVPAYLSTKGKFVVAVEIIAILASSYGLLG 239
                         250
                  ....*....|..
gi 1039778028 825 CIFVPKIYIILM 836
Cdd:cd15044   240 CIFLPKCYVILL 251
7tm_3 pfam00003
7 transmembrane sweet-taste receptor of 3 GCPR; This is a domain of seven transmembrane ...
580-830 2.92e-73

7 transmembrane sweet-taste receptor of 3 GCPR; This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G pfam07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor pfam01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness.


Pssm-ID: 459626 [Multi-domain]  Cd Length: 247  Bit Score: 240.25  E-value: 2.92e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 580 LSYEDPLGMALALMAFCFSAFTAVVLCVFVKHHDTPIVKANNRSLSYLLLMSLMSCFLCSFFFIGLPNrAICVLQQITFG 659
Cdd:pfam00003   1 LDLSAPWGIVLEALAALGILLTLVLLVVFLLHRKTPIVKASNRSLSFLLLLGLLLLFLLAFLFIGKPT-VTCALRRFLFG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 660 IVFTMAVSTVLAKTVTVVLAFKVTDPGRRLRNFLVsgtpnyIIPICSLLQCVLCAIWLAVsPPFVDIDEHTlHGHIIIVC 739
Cdd:pfam00003  80 VGFTLCFSCLLAKTFRLVLIFRRRKPGPRGWQLLL------LALGLLLVQVIILTEWLID-PPFPEKDNLS-EGKIILEC 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 740 NKGSVTAF-YCILGYLACLALGNFSVAFLAKNLPDTFNEAKFLTFSMLVFCSVWVTFLPVY-HSTKGKHM---VAVEIFS 814
Cdd:pfam00003 152 EGSTSIAFlDFVLAYVGLLLLAGFLLAFKTRKLPDNFNEAKFITFSMLLSVLIWVAFIPMYlYGNKGKGTwdpVALAIFA 231
                         250
                  ....*....|....*.
gi 1039778028 815 ILASSAGILGCIFVPK 830
Cdd:pfam00003 232 ILASGWVLLGLYFIPK 247
7tmC_V2R-like cd15280
vomeronasal type-2 receptor-like proteins, member of the class C family of seven-transmembrane ...
585-838 2.18e-59

vomeronasal type-2 receptor-like proteins, member of the class C family of seven-transmembrane G protein-coupled receptors; This group represents vomeronasal type-2 receptor-like proteins that are closely related to the V2R family of vomeronasal GPCRs. Members of the V2R family of vomeronasal GPCRs are involved in detecting protein pheromones for social and sexual cues between the same species. V2Rs and G-alpha(o) protein are coexpressed in the basal layer of the vomeronasal organ (VNO), which is the sensory organ of the accessory olfactory system present in amphibians, reptiles, and non-primate mammals such as mice and rodents, but it is non-functional or absent in humans, apes, and monkeys. On the other hand, members of the V1R receptor family and G-alpha(i2) protein are co-expressed in the apical neurons of the VNO. Activation of V1R or V2R causes activation of phospholipase pathway, generating the secondary messengers diacylglycerol (DAG) and IP3. However, in contrast to V1Rs, V2Rs contain the long N-terminal extracellular domain, which is believed to bind pheromones. Human V2R1-like protein, also known as putative calcium-sensing receptor-like 1 (CASRL1), is not included here because it is a nonfunctional pseudogene.


Pssm-ID: 320407 [Multi-domain]  Cd Length: 253  Bit Score: 202.71  E-value: 2.18e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 585 PLGMALALMAFCFSAFTAVVLCVFVKHHDTPIVKANNRSLSYLLLMSLMSCFLCSFFFIGLPNRAICVLQQITFGIVFTM 664
Cdd:cd15280     1 ALGITLIALSIFGALVVLAVTVVYIMHRHTPLVKANDRELSFLIQMSLVITFLTSILFIGKPENWSCMARQITLALGFSL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 665 AVSTVLAKTVTVVLAFKVTDPGRRLrnflVSGTPNY---IIPICSLLQCVLCAIWLAVSPPFVDIDEHTLHGHIIIVCNK 741
Cdd:cd15280    81 CLSSILGKTISLFLRYRASKSETRL----DSMHPIYqkiIVLICVLIEVGICTAYLILEPPRMYKNTEVQNVKIIFECNE 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 742 GSVTAFYCILGYLACLALGNFSVAFLAKNLPDTFNEAKFLTFSMLVFCSVWVTFLPVYHSTKGKHMVAVEIFSILASSAG 821
Cdd:cd15280   157 GSIEFLCSIFGFDVFLALLCFLTAFVARKLPDNFNEGKFITFGMLVFFIVWISFVPAYLSTRGKFKVAVEIFAILASSFG 236
                         250
                  ....*....|....*..
gi 1039778028 822 ILGCIFVPKIYIILMRP 838
Cdd:cd15280   237 LLGCIFVPKCYIILLKP 253
7tm_classC_mGluR-like cd13953
metabotropic glutamate receptor-like class C family of seven-transmembrane G protein-coupled ...
585-835 2.47e-56

metabotropic glutamate receptor-like class C family of seven-transmembrane G protein-coupled receptors superfamily; The class C GPCRs consist of glutamate receptors (mGluR1-8), the extracellular calcium-sensing receptors (caSR), the gamma-amino-butyric acid type B receptors (GABA-B), the vomeronasal type-2 pheromone receptors (V2R), the type 1 taste receptors (TAS1R), and the promiscuous L-alpha-amino acid receptor (GPRC6A), as well as several orphan receptors. Structurally, these receptors are typically composed of a large extracellular domain containing a Venus flytrap module which possesses the orthosteric agonist-binding site, a cysteine-rich domain (CRD) with the exception of GABA-B receptors, and the seven-transmembrane domains responsible for G protein activation. Moreover, the Venus flytrap module shows high structural homology with bacterial periplasmic amino acid-binding proteins, which serve as primary receptors in transport of a variety of soluble substrates such as amino acids and polysaccharides, among many others. The class C GPCRs exist as either homo- or heterodimers, which are essential for their function. The GABA-B1 and GABA-B2 receptors form a heterodimer via interactions between the N-terminal Venus flytrap modules and the C-terminal coiled-coiled domains. On the other hand, heterodimeric CaSRs and Tas1Rs and homodimeric mGluRs utilize Venus flytrap interactions and intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD), which can also acts as a molecular link to mediate the signal between the Venus flytrap and the 7TMs. Furthermore, members of the class C GPCRs bind a variety of endogenous ligands, ranging from amino acids, ions, to pheromones and sugar molecules, and play important roles in many physiological processes such as synaptic transmission, calcium homeostasis, and the sensation of sweet and umami tastes.


Pssm-ID: 320091 [Multi-domain]  Cd Length: 251  Bit Score: 193.99  E-value: 2.47e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 585 PLGMALALMAFCFSAFTAVVLCVFVKHHDTPIVKANNRSLSYLLLMSLMSCFLCSFFFIGLPNRAICVLQQITFGIVFTM 664
Cdd:cd13953     1 PLAIVLLVLAALGLLLTIFIWVVFIRYRNTPVVKASNRELSYLLLFGILLCFLLAFLFLLPPSDVLCGLRRFLFGLSFTL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 665 AVSTVLAKTVTVVLAFKVTDPGRRLRNFLVSGTPNYIIPICSLLQCVLCAIWLAVSPPFVDIDEHTlHGHIIIVCNKGSV 744
Cdd:cd13953    81 VFSTLLVKTNRIYRIFKSGLRSSLRPKLLSNKSQLLLVLFLLLVQVAILIVWLILDPPKVEKVIDS-DNKVVELCCSTGN 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 745 TAFYCILGYLACLALGNFSVAFLAKNLPDTFNEAKFLTFSMLVFCSVWVTFLPVYHSTKGKHMVAVEIFSILASSAGILG 824
Cdd:cd13953   160 IGLILSLVYNILLLLICTYLAFKTRKLPDNFNEARYIGFSSLLSLVIWIAFIPTYFTTSGPYRDAILSFGLLLNATVLLL 239
                         250
                  ....*....|.
gi 1039778028 825 CIFVPKIYIIL 835
Cdd:cd13953   240 CLFLPKIYIIL 250
7tmC_CaSR cd15282
calcium-sensing receptor, member of the class C of seven-transmembrane G protein-coupled ...
585-835 8.48e-54

calcium-sensing receptor, member of the class C of seven-transmembrane G protein-coupled receptors; CaSR is a widely expressed GPCR that is involved in sensing small changes in extracellular levels of calcium ion to maintain a constant level of the extracellular calcium via modulating the synthesis and secretion of calcium regulating hormones, such as parathyroid hormone (PTH), in order to regulate Ca(2+)transport into or out of the extracellular fluid via kidney, intestine, and/or bone. For instance, when Ca2+ is high, CaSR downregulates PTH synthesis and secretion, leading to an increase in renal Ca2+ excretion, a decrease in intestinal Ca2+ absorption, and a reduction in release of skeletal Ca2+. CaSR is coupled to both G(q/11)-dependent activation of phospholipase and, subsequently, intracellular calcium mobilization and protein kinase C activation as well as G(i/o)-dependent inhibition of adenylate cyclase leading to inhibition of cAMP formation. CaSR is closely related to GRPC6A (GPCR, class C, group 6, subtype A), which is an amino acid-sensing GPCR that is most potently activated by the basic amino acids L-arginine, L-lysine, and L-ornithine. These receptors contain a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD), and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B1, GPRC6A, mGlu, and TASR1 receptors.


Pssm-ID: 320409 [Multi-domain]  Cd Length: 252  Bit Score: 187.08  E-value: 8.48e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 585 PLGMALALMAFCFSAFTAVVLCVFVKHHDTPIVKANNRSLSYLLLMSLMSCFLCSFFFIGLPNRAICVLQQITFGIVFTM 664
Cdd:cd15282     1 PFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLICCFSSSLIFIGEPQDWTCRLRQPAFGISFVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 665 AVSTVLAKTVTVVLAFKVTDPGRRLRNFLVSGTPNYIIPICSLLQCVLCAIWLAVSPPFVDIDEHTLHGHIIIVCNKGSV 744
Cdd:cd15282    81 CISCILVKTNRVLLVFEAKIPTSLHRKWWGLNLQFLLVFLCTFVQIVICVIWLYTAPPSSYRNHELEDEIIFITCNEGSL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 745 TAFYCILGYLACLALGNFSVAFLAKNLPDTFNEAKFLTFSMLVFCSVWVTFLPVYHSTKGKHMVAVEIFSILASSAGILG 824
Cdd:cd15282   161 MALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILASSFGLLA 240
                         250
                  ....*....|.
gi 1039778028 825 CIFVPKIYIIL 835
Cdd:cd15282   241 CIFFNKVYIIL 251
7tmC_GPRC6A cd15281
class C of seven-transmembrane G protein-coupled receptors, subtype 6A; GRPC6A (GPCR, class C, ...
586-835 1.85e-48

class C of seven-transmembrane G protein-coupled receptors, subtype 6A; GRPC6A (GPCR, class C, group 6, subtype A) is a widely expressed amino acid-sensing GPCR that is most closely related to CaSR. GPRC6A is most potently activated by the basic amino acids L-arginine, L-lysine, and L-ornithine and less potently by small aliphatic amino acids. Moreover, the receptor can be either activated or modulated by divalent cations such as Ca2+ and Mg2+. GPRC6A is expressed in the testis, but not the ovary and specifically also binds to the osteoblast-derived hormone osteocalcin (OCN), which regulates testosterone production by the testis and male fertility independently of the hypothalamic-pituitary axis. Furthermore, GPRC6A knockout studies suggest that GRPC6A is involved in regulation of bone metabolism, male reproduction, energy homeostasis, glucose metabolism, and in activation of inflammation response, as well as prostate cancer growth and progression, among others. GPRC6A has been suggested to couple to the Gq subtype of G proteins, leading to IP3 production and intracellular calcium mobilization. GPRC6A contains a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD), and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B, GPRC6A, mGlu, and TAS1R receptors.


Pssm-ID: 320408  Cd Length: 249  Bit Score: 172.27  E-value: 1.85e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 586 LGMALALMAFCFSAFTAVVLCVFVKHHDTPIVKANNRSLSYLLLMSLMSCFLCSFFFIGLPNRAICVLQQITFGIVFTMA 665
Cdd:cd15281     2 FAIVLLILSALGVLLIFFISALFTKNLNTPVVKAGGGPLCYVILLSHFGSFISTVFFIGEPSDLTCKTRQTLFGISFTLC 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 666 VSTVLAKTVTVVLAFKVtDPgrRLRNFL-VSGTPNYIIPICSLLQCVLCAIWLAVSPPFVDiDEHTLHGHIIIVCNKGSV 744
Cdd:cd15281    82 VSCILVKSLKILLAFSF-DP--KLQELLkCLYKPIMIVFICTGIQVIICTVWLVFYKPFVD-KNFSLPESIILECNEGSY 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 745 TAFYCILGYLACLALGNFSVAFLAKNLPDTFNEAKFLTFSMLVFCSVWVTFLPVYHSTKGKHMVAVEIFSILASSAGILG 824
Cdd:cd15281   158 VAFGLMLGYIALLAFICFIFAFKGRKLPENYNEAKFITFGMLIYFIAWITFIPIYATTFGKYVPAVEMIVILISNYGILS 237
                         250
                  ....*....|.
gi 1039778028 825 CIFVPKIYIIL 835
Cdd:cd15281   238 CTFLPKCYIIL 248
7tmC_mGluRs cd15045
metabotropic glutamate receptors, member of the class C family of seven-transmembrane G ...
591-836 6.94e-36

metabotropic glutamate receptors, member of the class C family of seven-transmembrane G protein-coupled receptors; The metabotropic glutamate receptors (mGluRs) are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group I mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to (Gi/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320173 [Multi-domain]  Cd Length: 253  Bit Score: 136.61  E-value: 6.94e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 591 ALMAFCFSAF----TAVVLCVFVKHHDTPIVKANNRSLSYLLLMSLMSCFLCSFFFIGLPNRAICVLQQITFGIVFTMAV 666
Cdd:cd15045     3 AIGAMAFASLgillTLFVLVVFVRYRDTPVVKASGRELSYVLLAGILLSYVMTFVLVAKPSTIVCGLQRFGLGLCFTVCY 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 667 STVLAKTVTVVLAFKVTDPGRRLRNFLvsgTPNYIIPICSLL---QCVLCAIWLAVSPPfvdideHTLHGHII-----IV 738
Cdd:cd15045    83 AAILTKTNRIARIFRLGKKSAKRPRFI---SPRSQLVITGLLvsvQVLVLAVWLILSPP------RATHHYPTrdknvLV 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 739 CNKGSVTAFYCILGYLACLALGNFSVAFLAKNLPDTFNEAKFLTFSMLVFCSVWVTFLPVYHSTKGKHMVAVEIFSILAS 818
Cdd:cd15045   154 CSSALDASYLIGLAYPILLIILCTVYAFKTRKIPEGFNEAKYIGFTMYTTCIIWLAFVPLYFTTASNIEVRITTLSVSIS 233
                         250       260
                  ....*....|....*....|
gi 1039778028 819 SAG--ILGCIFVPKIYIILM 836
Cdd:cd15045   234 LSAtvQLACLFAPKVYIILF 253
PBP1_GPCR_family_C-like cd06350
ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory ...
74-340 2.50e-33

ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory transmission on the cellular surface through initial binding of glutamate; categorized into ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (m; Ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory transmission on the cellular surface through initial binding of glutamate and are categorized into ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (mGluRs). The metabotropic glutamate receptors (mGluR) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. The mGluRs are coupled to G proteins and are thus distinct from the iGluRs which internally contain ligand-gated ion channels. The mGluR structure is divided into three regions: the extracellular region, the seven-spanning transmembrane region and the cytoplasmic region. The extracellular region is further divided into the ligand-binding domain (LBD) and the cysteine-rich domain. The LBD has sequence similarity to the LIVBP, which is a bacterial periplasmic protein (PBP), as well as to the extracellular region of both iGluR and the gamma-aminobutyric acid (GABA)b receptor. iGluRs are divided into three main subtypes based on pharmacological profile: NMDA, AMPA, and kainate receptors. All family C GPCRs have a large extracellular N terminus that contain a domain with homology to bacterial periplasmic amino acid-binding proteins.


Pssm-ID: 380573  Cd Length: 350  Bit Score: 132.03  E-value: 2.50e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028  74 YALALVFAMDEINRNPDLLPNMSL--IIRYTlgrCDGKTV-IPTPYLFRKKKESPIPNYFCNEETMCSYLLT--GP-HWE 147
Cdd:cd06350    29 LVEAMIYAIEEINNDSSLLPNVTLgyDIRDT---CSSSSVaLESSLEFLLDNGIKLLANSNGQNIGPPNIVAviGAaSSS 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 148 VSLGFWKHMNSFLSPrilQLTYGPFHSIFSDDEQYPYLYQMAPKDTSLALAMVSFILYFSWNWIGLVIPDDDQGNQFLLE 227
Cdd:cd06350   106 VSIAVANLLGLFKIP---QISYASTSPELSDKIRYPYFLRTVPSDTLQAKAIADLLKHFNWNYVSTVYSDDDYGRSGIEA 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 228 LKKQSENKEICFAFVKMISvddvsfPQNTEMYYNQIV-----MSSTNVIIIYGETYNFIDLIFRMWEPPILQRIWITTKQ 302
Cdd:cd06350   183 FEREAKERGICIAQTIVIP------ENSTEDEIKRIIdklksSPNAKVVVLFLTESDARELLKEAKRRNLTGFTWIGSDG 256
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1039778028 303 LNFPTRKKDISHGTFYGSLTFLPHHGVISGFKNFVQTW 340
Cdd:cd06350   257 WGDSLVILEGYEDVLGGAIGVVPRSKEIPGFDDYLKSY 294
7tmC_mGluRs_group2_3 cd15934
metabotropic glutamate receptors in group 2 and 3, member of the class C family of ...
589-835 7.47e-33

metabotropic glutamate receptors in group 2 and 3, member of the class C family of seven-transmembrane G protein-coupled receptors; The metabotropic glutamate receptors (mGluRs) are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. The mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group I mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to (Gi/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320600  Cd Length: 252  Bit Score: 127.73  E-value: 7.47e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 589 ALALMAFCFSAF----TAVVLCVFVKHHDTPIVKANNRSLSYLLLMSLMSCFLCSFFFIGLPNRAICVLQQITFGIVFTM 664
Cdd:cd15934     1 PWAIVPVVFALLgilaTLFVIVVFIRYNDTPVVKASGRELSYVLLTGILLCYLMTFVLLAKPSVITCALRRLGLGLGFSI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 665 AVSTVLAKTVTVvlaFKVTDPGRRlrnflvSGT-PNYIIP-----ICSLL---QCVLCAIWLAVSPPFVDIDeHTLHGHI 735
Cdd:cd15934    81 CYAALLTKTNRI---SRIFNSGKR------SAKrPRFISPksqlvICLGLisvQLIGVLVWLVVEPPGTRID-YPRRDQV 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 736 IIVCNkGSVTAFYCILGYLACLALGNFSVAFLAKNLPDTFNEAKFLTFSMLVFCSVWVTFLPVYHSTKGKHMVAVEIFSI 815
Cdd:cd15934   151 VLKCK-ISDSSLLISLVYNMLLIILCTVYAFKTRKIPENFNEAKFIGFTMYTTCIIWLAFVPIYFGTSNDFKIQTTTLCV 229
                         250       260
                  ....*....|....*....|..
gi 1039778028 816 LAS-SAGI-LGCIFVPKIYIIL 835
Cdd:cd15934   230 SISlSASVaLGCLFAPKVYIIL 251
7tmC_mGluR2 cd15447
metabotropic glutamate receptor 2 in group 2, member of the class C family of ...
601-835 9.21e-33

metabotropic glutamate receptor 2 in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors; The metabotropic glutamate receptors (mGluRs) in group 2 include mGluR 2 and 3. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320563  Cd Length: 254  Bit Score: 127.35  E-value: 9.21e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 601 TAVVLCVFVKHHDTPIVKANNRSLSYLLLMSLMSCFLCSFFFIGLPNRAICVLQQITFGIVFTMAVSTVLAKTVTVVLAF 680
Cdd:cd15447    17 TLFVVGVFVKNNETPVVKASGRELCYILLLGVLLCYLMTFIFIAKPSTAVCTLRRLGLGTSFAVCYSALLTKTNRIARIF 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 681 KVTDPGRRLRNFLvsgTPNYIIPICSLL---QCVLCAIWLAVSPPFVDIDEHTLHGHIIIV-CNKGSVTAFYCiLGYLAC 756
Cdd:cd15447    97 SGAKDGAQRPRFI---SPASQVAICLALiscQLLVVLIWLLVEAPGTRKETAPERRYVVTLkCNSRDSSMLIS-LTYNVL 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 757 LALGNFSVAFLAKNLPDTFNEAKFLTFSMLVFCSVWVTFLPVYHSTKGKHMVAVEIFSILASSAG--ILGCIFVPKIYII 834
Cdd:cd15447   173 LIILCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGsvVLGCLFAPKLHII 252

                  .
gi 1039778028 835 L 835
Cdd:cd15447   253 L 253
7tmC_TAS1R1 cd15289
type 1 taste receptor subtype 1, member of the class C of seven-transmembrane G ...
588-835 3.99e-32

type 1 taste receptor subtype 1, member of the class C of seven-transmembrane G protein-coupled receptors; This group represents TAS1R1, which is a member of the type I taste receptor (TAS1R) family that belongs to the class C of G protein-coupled receptors. The functional TAS1Rs are obligatory heterodimers built from three known members, TAS1R1-3. TAS1R1 combines with TAS1R3 to form an umami taste receptor, which is responsible for the perception of savory taste, such as the food additive mono-sodium glutamate (MSG); whereas the combination of TAS1R2-TAS1R3 forms a sweet-taste receptor for sugars and D-amino acids. On the other hand, the type II taste receptors (TAS2Rs), which belong to the class A family of GPCRs, recognize bitter tasting compounds. In the case of sweet, for example, the TAS1R2-TAS1R3 heterodimer activates phospholipase C (PLC) via alpha-gustducin, a heterodimeric G protein that is involved in perception of sweet and bitter tastes. This activation leads to generation of inositol (1, 4, 5)-trisphosphate (IP3) and diacylglycerol (DAG), and consequently increases intracellular Ca2+ mobilization and activates a cation channel, TRPM5. In contrast to the TAS1R2-TAS1R3 heterodimer, TAS1R3 alone could activate adenylate cyclase leading to cAMP formation in the absence of alpha-gustducin. Each TAS1R contains a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD) and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B1, GPRC6A, mGlu, and TAS1R receptors.


Pssm-ID: 320416  Cd Length: 253  Bit Score: 125.61  E-value: 3.99e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 588 MALALMAF--CFSAFTAVVLCVFVKHHDTPIVK-ANNRSlsylllmslmsCFL---------CSFF-FIGLPNRAICVLQ 654
Cdd:cd15289     2 VSWALLTAltLLLLLLAGTALLFALNLTTPVVKsAGGRT-----------CFLmlgslaaasCSLYcHFGEPTWLACLLK 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 655 QITFGIVFTMAVSTVLAKTVTVVLAFKVTDPGRRL-RNFLVSGTPNYIIPICSLLQCVLCAIWLAVSPPFVDIDEHTLHG 733
Cdd:cd15289    71 QPLFSLSFTVCLSCIAVRSFQIVCIFKLASKLPRFyETWAKNHGPELFILISSAVQLLISLLWLVLNPPVPTKDYDRYPD 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 734 HIIIVCNKGSVTAFYCILGYLACLALGNFSVAFLAKNLPDTFNEAKFLTFSMLVFCSVWVTFLPVYHSTKGKHMVAVEIF 813
Cdd:cd15289   151 LIVLECSQTLSVGSFLELLYNCLLSISCFVFSYMGKDLPANYNEAKCITFSLLIYFISWISFFTTYSIYRGKYLMAINVL 230
                         250       260
                  ....*....|....*....|..
gi 1039778028 814 SILASSAGILGCIFVPKIYIIL 835
Cdd:cd15289   231 AILSSLLGIFGGYFLPKVYIIL 252
7tmC_TAS1R3 cd15290
type 1 taste receptor subtype 3, member of the class C of seven-transmembrane G ...
585-835 8.91e-32

type 1 taste receptor subtype 3, member of the class C of seven-transmembrane G protein-coupled receptors; This group represents TAS1R3, which is a member of the type I taste receptor (TAS1R) family that belongs to the class C of G protein-coupled receptors. The functional TAS1Rs are obligatory heterodimers built from three known members, TAS1R1-3. TAS1R1 combines with TAS1R3 to form an umami taste receptor, which is responsible for the perception of savory taste, such as the food additive mono-sodium glutamate (MSG); whereas the combination of TAS1R2-TAS1R3 forms a sweet-taste receptor for sugars and D-amino acids. On the other hand, the type II taste receptors (TAS2Rs), which belong to the class A family of GPCRs, recognize bitter tasting compounds. In the case of sweet, for example, the TAS1R2-TAS1R3 heterodimer activates phospholipase C (PLC) via alpha-gustducin, a heterodimeric G protein that is involved in perception of sweet and bitter tastes. This activation leads to generation of inositol (1, 4, 5)-trisphosphate (IP3) and diacylglycerol (DAG), and consequently increases intracellular Ca2+ mobilization and activates a cation channel, TRPM5. In contrast to the TAS1R2-TAS1R3 heterodimer, TAS1R3 alone could activate adenylate cyclase leading to cAMP formation in the absence of alpha-gustducin. Each TAS1R contains a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD) and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B1, GPRC6A, mGlu, and TAS1R receptors.


Pssm-ID: 320417 [Multi-domain]  Cd Length: 253  Bit Score: 124.40  E-value: 8.91e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 585 PLGMALALMAFCFSAFTAVVLCVFVKHHDTPIVKANNRSLSYLLLMSLMSCFLCSFFFIGLPNRAICVLQQITFGIVFTM 664
Cdd:cd15290     1 PESLGLLLLGVLLLVLQCSVGVLFLKHRGTPLVQASGGPLSIFALLSLMGACLSLLLFLGQPSDVVCRLQQPLNALFLTV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 665 AVSTVLAKTVTVVLAFKVTDPGRRLRNFLVSGTPNYIIPICSLLQCVLCAIWLAVSPPFVDIDEH-TLHGHIIIVCNKGS 743
Cdd:cd15290    81 CLSTILSISLQIFLVTEFPKCAASHLHWLRGPGSWLVVLICCLVQAGLCGWYVQDGPSLSEYDAKmTLFVEVFLRCPVEP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 744 VTAFYCILGYLACLALGNFSVAFLAKNLPDTFNEAKFLTFSMLVFCSVWVTFLPVYHSTKGKHMVAVEIFSILASSAGIL 823
Cdd:cd15290   161 WLGFGLMHGFNGALALISFMCTFMAQKPLKQYNLARDITFSTLIYCVTWVIFIPIYAGLQVKLRSIAQVGFILLSNLGLL 240
                         250
                  ....*....|..
gi 1039778028 824 GCIFVPKIYIIL 835
Cdd:cd15290   241 AAYYLPKCYLLL 252
7tmC_mGluR_group3 cd15286
metabotropic glutamate receptors in group 3, member of the class C family of ...
585-845 8.58e-31

metabotropic glutamate receptors in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors; The metabotropic glutamate receptors (mGluRs) in group 3 include mGluRs 4, 6, 7, and 8. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320413  Cd Length: 271  Bit Score: 122.22  E-value: 8.58e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 585 PLGMA-LALMAfcfsafTAVVLCVFVKHHDTPIVKANNRSLSYLLLMSLMSCFLCSFFFIGLPNRAICVLQQITFGIVFT 663
Cdd:cd15286     6 PVALAvLGIIA------TLFVLVTFVRYNDTPIVRASGRELSYVLLTGIFLCYAITFLMVAEPGVGVCSLRRLFLGLGMS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 664 MAVSTVLAKTVTVVLAFK-----VTDPGrrlrnfLVSGTPNYIIPI-CSLLQCVLCAIWLAVSPP--FVDIDEHTL---- 731
Cdd:cd15286    80 LSYAALLTKTNRIYRIFEqgkksVTPPR------FISPTSQLVITFsLISVQLLGVLAWFAVDPPhaLIDYEEGRTpdpe 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 732 HGHIIIVCNKgSVTAFYCILGYLACLALGNFSVAFLAKNLPDTFNEAKFLTFSMLVFCSVWVTFLPVY----HSTKGKHM 807
Cdd:cd15286   154 QARGVLRCDM-SDLSLICCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIVWLAFIPIFfgtaQSAEKLYI 232
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1039778028 808 VAVEIFSILASSAGI-LGCIFVPKIYIILMRPERNSTQK 845
Cdd:cd15286   233 QTATLTVSMSLSASVsLGMLYMPKVYVILFHPEQNVQKR 271
7tmC_mGluR4 cd15452
metabotropic glutamate receptor 4 in group 3, member of the class C family of ...
585-847 9.12e-30

metabotropic glutamate receptor 4 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors; The receptors in group 3 include mGluRs 4, 6, 7, and 8. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320568 [Multi-domain]  Cd Length: 327  Bit Score: 120.86  E-value: 9.12e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 585 PLGMALALMAFCFSAFTAVVLCVFVKHHDTPIVKANNRSLSYLLLMSLMSCFLCSFFFIGLPNRAICVLQQITFGIVFTM 664
Cdd:cd15452     1 PWAVVPLLLAVLGIIATLFVVVTFVRYNDTPIVKASGRELSYVLLTGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 665 AVSTVLAKTVTVvlaFKVTDPGRRlrnfLVSGtPNYIIPICSL--------LQCVLCAIWLAVSP--PFVDI-DEHTLHG 733
Cdd:cd15452    81 SYAALLTKTNRI---YRIFEQGKR----SVSA-PRFISPASQLvitfslisLQLLGVCVWFLVDPshSVVDYeDQRTPDP 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 734 HI---IIVCNKGSVTaFYCILGYLACLALGNFSVAFLAKNLPDTFNEAKFLTFSMLVFCSVWVTFLPVY----HSTKGKH 806
Cdd:cd15452   153 QFargVLKCDISDLS-LICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFfgtsQSAEKMY 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1039778028 807 MVAVEIFSILASSAGI-LGCIFVPKIYIILMRPERNSTQKIR 847
Cdd:cd15452   232 IQTTTLTISVSLSASVsLGMLYMPKVYVILFHPEQNVPKRKR 273
7tmC_mGluR_group2 cd15284
metabotropic glutamate receptors in group 2, member of the class C family of ...
601-835 1.16e-29

metabotropic glutamate receptors in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors; The metabotropic glutamate receptors (mGluRs) in group 2 include mGluR 2 and 3. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320411  Cd Length: 254  Bit Score: 118.41  E-value: 1.16e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 601 TAVVLCVFVKHHDTPIVKANNRSLSYLLLMSLMSCFLCSFFFIGLPNRAICVLQQITFGIVFTMAVSTVLAKTVTVVLAF 680
Cdd:cd15284    17 TLFVIGVFIKHNNTPLVKASGRELCYILLFGVFLCYCMTFIFIAKPSPAICTLRRLGLGTSFAVCYSALLTKTNRIARIF 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 681 KVTDPGRRLRNFLvsgTPNYIIPICSLL---QCVLCAIWLAVSPPFVDIDEHTLHGHIIIV-CNKGSvTAFYCILGYLAC 756
Cdd:cd15284    97 SGVKDGAQRPRFI---SPSSQVFICLALisvQLLVVSVWLLVEAPGTRRYTLPEKRETVILkCNVRD-SSMLISLTYDVV 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 757 LALGNFSVAFLAKNLPDTFNEAKFLTFSMLVFCSVWVTFLPVYHSTKGKHMVAVEIFSILASSAG--ILGCIFVPKIYII 834
Cdd:cd15284   173 LVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGfvVLGCLFAPKVHII 252

                  .
gi 1039778028 835 L 835
Cdd:cd15284   253 L 253
7tmC_mGluR3 cd15448
metabotropic glutamate receptor 3 in group 2, member of the class C family of ...
601-835 2.87e-29

metabotropic glutamate receptor 3 in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors; The metabotropic glutamate receptors (mGluRs) in group 2 include mGluR 2 and 3. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320564  Cd Length: 254  Bit Score: 117.36  E-value: 2.87e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 601 TAVVLCVFVKHHDTPIVKANNRSLSYLLLMSLMSCFLCSFFFIGLPNRAICVLQQITFGIVFTMAVSTVLAKTVTVVLAF 680
Cdd:cd15448    17 TCMVITVFIKHNNTPLVKASGRELCYILLFGVFLSYCMTFFFIAKPSPVICTLRRLGLGTSFAVCYSALLTKTNCIARIF 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 681 KVTDPGRRLRNFLVSGTPNYIIPICSLLQCVLCAIWLAVSPPfvDIDEHTL---HGHIIIVCNKGSvTAFYCILGYLACL 757
Cdd:cd15448    97 DGVKNGAQRPKFISPSSQVFICLSLILVQIVVVSVWLILEAP--GTRRYTLpekRETVILKCNVKD-SSMLISLTYDVVL 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 758 ALGNFSVAFLAKNLPDTFNEAKFLTFSMLVFCSVWVTFLPVYHSTKGKHMVAVEIFSILASSAG--ILGCIFVPKIYIIL 835
Cdd:cd15448   174 VILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGfvVLGCLFAPKVHIIL 253
7tmC_mGluR_group1 cd15285
metabotropic glutamate receptors in group 1, member of the class C family of ...
591-836 1.73e-28

metabotropic glutamate receptors in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors; Group 1 mGluRs includes mGluR1 and mGluR5, as well as their closely related invertebrate receptors. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320412  Cd Length: 250  Bit Score: 115.04  E-value: 1.73e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 591 ALMAFCFSAF----TAVVLCVFVKHHDTPIVKANNRSLSYLLLMSLMSCFLCSFFFIGLPNRAICVLQQITFGIVFTMAV 666
Cdd:cd15285     3 AIVAMVFACVgilaTLFVTVVFIRHNDTPVVKASTRELSYIILAGILLCYASTFALLAKPSTISCYLQRILPGLSFAMIY 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 667 STVLAKT--VTVVLA-FKVTDPGRRLRnFLVSGTPNYIIPICSLLQCVLCAIWLAVSPPfVDIDEHTLHGHIIIVCNKgS 743
Cdd:cd15285    83 AALVTKTnrIARILAgSKKKILTRKPR-FMSASAQVVITGILISVEVAIIVVMLILEPP-DATLDYPTPKRVRLICNT-S 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 744 VTAFYCILGYLACLALGNFSVAFLAKNLPDTFNEAKFLTFSMLVFCSVWVTFLPVYHSTKGKHMVAVeiFSILASSAGIL 823
Cdd:cd15285   160 TLGFVVPLGFDFLLILLCTLYAFKTRNLPENFNEAKFIGFTMYTTCVIWLAFLPIYFGSDNKEITLC--FSVSLSATVAL 237
                         250
                  ....*....|...
gi 1039778028 824 GCIFVPKIYIILM 836
Cdd:cd15285   238 VFLFFPKVYIILF 250
PBP1_CaSR cd06364
ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors ...
73-453 1.04e-27

ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily; Ligand-binding domain of the CaSR calcium-sensing receptor, which is a member of the family C receptors within the G-protein coupled receptor superfamily. CaSR provides feedback control of extracellular calcium homeostasis by responding sensitively to acute fluctuations in extracellular ionized Ca2+ concentration. This ligand-binding domain has homology to the bacterial leucine-isoleucine-valine binding protein (LIVBP) and a leucine binding protein (LBP). CaSR is widely expressed in mammalian tissues and is active in tissues that are not directly involved in extracellular calcium homeostasis. Moreover, CaSR responds to aromatic, aliphatic, and polar amino acids, but not to positively charged or branched chain amino acids, which suggests that changes in plasma amino acid levels are likely to modulate whole body calcium metabolism. Additionally, the family C GPCRs includes at least two receptors with broad-spectrum amino acid-sensing properties: GPRC6A which recognizes basic and various aliphatic amino acids, its gold-fish homolog the 5.24 chemoreceptor, and a specific taste receptor (T1R) which responds to aliphatic, polar, charged, and branched amino acids, but not to aromatic amino acids.


Pssm-ID: 380587 [Multi-domain]  Cd Length: 473  Bit Score: 117.74  E-value: 1.04e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028  73 KYALALVFAMDEINRNPDLLPNMSLIIRyTLGRCD--GKTVIPTpYLFRKKKESPIPNYFCNeetmcsyllTGPHWEVSL 150
Cdd:cd06364    37 RWAQTMIFAIEEINNSPDLLPNITLGYR-IYDSCAtiSKALRAA-LALVNGQEETNLDERCS---------GGPPVAAVI 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 151 GFWKHMNSFLSPRILqltyGPFH----------SIFSDDEQYPYLYQMAPKDTSLALAMVSFILYFSWNWIGLVIPDDDQ 220
Cdd:cd06364   106 GESGSTLSIAVARTL----GLFYipqvsyfascACLSDKKQFPSFLRTIPSDYYQSRALAQLVKHFGWTWVGAIASDDDY 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 221 GNQFLLELKKQSENKEICFAFVKMISVddvsfpqntemYYNQ--------IVMSST-NVIIIY---GETYNFIDLIF--- 285
Cdd:cd06364   182 GRNGIKAFLEEAEKLGICIAFSETIPR-----------TYSQekilriveVIKKSTaKVIVVFsseGDLEPLIKELVrqn 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 286 ---RMWeppILQRIWITTKQLNFPtrkkdISHGTFYGSLTFLPHHGVISGFKNFVQTWFHLRNTDLYLVMQEWKY-FNye 361
Cdd:cd06364   251 itgRQW---IASEAWITSSLLATP-----EYFPVLGGTIGFAIRRGEIPGLKEFLLRVHPSKSPSNPFVKEFWEEtFN-- 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 362 dsastCK---ILKNNSSNASF------DWLMEQK---FDMTFSENSHNIYNAVHAIAHALHEMNLQQADNQAIDNGKGAS 429
Cdd:cd06364   321 -----CSlssSSKSNSSSSSRppctgsENLENVQnpyTDVSQLRISYNVYKAVYAIAHALHDLLQCEPGKGPFSNGSCAD 395
                         410       420
                  ....*....|....*....|....*..
gi 1039778028 430 SHCLK---VNSFLRRIYFTNPPGDKVF 453
Cdd:cd06364   396 IKKVEpwqLLYYLKHVNFTTKFGEEVY 422
7tmC_TAS1R cd15046
type 1 taste receptors, member of the class C of seven-transmembrane G protein-coupled ...
585-836 2.51e-27

type 1 taste receptors, member of the class C of seven-transmembrane G protein-coupled receptors; This subfamily represents the type I taste receptors (TAS1Rs) that belongs to the class C family of G protein-coupled receptors. The functional TAS1Rs are obligatory heterodimers built from three known members, TAS1R1-3. TAS1R1 combines with TAS1R3 to form an umami taste receptor, which is responsible for the perception of savory taste, such as the food additive mono-sodium glutamate (MSG); whereas the combination of TAS1R2-TAS1R3 forms a sweet-taste receptor for sugars and D-amino acids. On the other hand, the type II taste receptors (TAS2Rs), which belong to the class A family of GPCRs, recognize bitter tasting compounds. In the case of sweet, for example, the TAS1R2-TAS1R3 heterodimer activates phospholipase C (PLC) via alpha-gustducin, a heterodimeric G protein that is involved in perception of sweet and bitter tastes. This activation leads to generation of inositol (1, 4, 5)-trisphosphate (IP3) and diacylglycerol (DAG), and consequently increases intracellular Ca2+ mobilization and activates a cation channel, TRPM5. In contrast to the TAS1R2-TAS1R3 heterodimer, TAS1R3 alone could activate adenylate cyclase leading to cAMP formation in the absence of alpha-gustducin. Each TAS1R contains a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD) and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B1, GPRC6A, mGlu, and TAS1R receptors.


Pssm-ID: 320174 [Multi-domain]  Cd Length: 253  Bit Score: 111.85  E-value: 2.51e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 585 PLGMALALMAFCFSAFTAVVLCVFVKHHDTPIVKANNRSLSYLLLMSLMSCFLCSFFFIGLPNRAICVLQQITFGIVFTM 664
Cdd:cd15046     1 APTVAVLLLAALGLLSTLAILVIFWRNFNTPVVRSAGGPMCFLMLTLLLVAYMSVPVYFGPPKVSTCLLRQALFPLCFTV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 665 AVSTVLAKTVTVVLAFKVTDPGRRLRNFLVSGT-PNYIIPICSLLQCVLCAIWLAVSP--PFVDIDEHTlhGHIIIVCNK 741
Cdd:cd15046    81 CLACIAVRSFQIVCIFKMASRFPRAYSYWVKYHgPYVSIAFITVLKMVIVVIGMLATPpsPTTDTDPDP--KITIVSCNP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 742 GSVTAFYCILGYLACLALGNFSVAFLAKNLPDTFNEAKFLTFSMLVFCSVWVTFLPVYHSTKGKHMVAVEIFSILASSAG 821
Cdd:cd15046   159 NYRNSSLFNTSLDLLLSVVCFSFSYMGKDLPTNYNEAKFITFSLTFYFTSWISFCTFMLAYSGVLVTIVDLLATLLSLLA 238
                         250
                  ....*....|....*
gi 1039778028 822 ILGCIFVPKIYIILM 836
Cdd:cd15046   239 FSLGYFLPKCYIILF 253
7tmC_mGluR6 cd15453
metabotropic glutamate receptor 6 in group 3, member of the class C family of ...
601-847 1.30e-26

metabotropic glutamate receptor 6 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors; The receptors in group 3 include mGluRs 4, 6, 7, and 8. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320569 [Multi-domain]  Cd Length: 273  Bit Score: 110.12  E-value: 1.30e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 601 TAVVLCVFVKHHDTPIVKANNRSLSYLLLMSLMSCFLCSFFFIGLPNRAICVLQQITFGIVFTMAVSTVLAKTVTVvlaF 680
Cdd:cd15453    17 TTTVVITFVRFNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAFRRLFLGLGTTLSYSALLTKTNRI---Y 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 681 KVTDPGRRlrnflvSGT-PNYIIPICSL--------LQCVLCAIWLAVSPP--FVDIDEHTL----HGHIIIVCNKGSVT 745
Cdd:cd15453    94 RIFEQGKR------SVTpPPFISPTSQLvitfsltsLQVVGVIAWLGAQPPhsVIDYEEQRTvdpeQARGVLKCDMSDLS 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 746 AFYCiLGYLACLALGNFSVAFLAKNLPDTFNEAKFLTFSMLVFCSVWVTFLPVYHST-KGKHMVAVEIFSILAS---SAG 821
Cdd:cd15453   168 LIGC-LGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTaQSAEKIYIQTTTLTVSlslSAS 246
                         250       260
                  ....*....|....*....|....*..
gi 1039778028 822 I-LGCIFVPKIYIILMRPERNSTQKIR 847
Cdd:cd15453   247 VsLGMLYVPKTYVILFHPEQNVQKRKR 273
7tmC_mGluR7 cd15451
metabotropic glutamate receptor 7 in group 3, member of the class C family of ...
601-847 1.24e-24

metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors; The receptors in group 3 include mGluRs 4, 6, 7, and 8. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320567  Cd Length: 307  Bit Score: 105.49  E-value: 1.24e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 601 TAVVLCVFVKHHDTPIVKANNRSLSYLLLMSLMSCFLCSFFFIGLPNRAICVLQQITFGIVFTMAVSTVLAKTVTVvlaF 680
Cdd:cd15451    17 TIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRIFLGLGMCISYAALLTKTNRI---Y 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 681 KVTDPGRRLRNFLVSGTPNYIIPICSLLQCVL---CAIWLAVSPP--FVDIDEH-TLHGHIIIVCNKGSVT--AFYCILG 752
Cdd:cd15451    94 RIFEQGKKSVTAPRLISPTSQLAITSSLISVQllgVLIWFAVDPPniIIDYDEQkTMNPEQARGVLKCDITdlQIICSLG 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 753 YLACLALGNFSVAFLAKNLPDTFNEAKFLTFSMLVFCSVWVTFLPVYHST-----KGKHMVAVEIFSILASSAGILGCIF 827
Cdd:cd15451   174 YSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTaqsaeKLYIQTTTLTISMNLSASVALGMLY 253
                         250       260
                  ....*....|....*....|
gi 1039778028 828 VPKIYIILMRPERNSTQKIR 847
Cdd:cd15451   254 MPKVYIIIFHPELNVQKRKR 273
7tmC_mGluR8 cd15454
metabotropic glutamate receptor 8 in group 3, member of the class C family of ...
601-847 2.12e-24

metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors; The receptors in group 3 include mGluRs 4, 6, 7, and 8. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320570 [Multi-domain]  Cd Length: 311  Bit Score: 104.72  E-value: 2.12e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 601 TAVVLCVFVKHHDTPIVKANNRSLSYLLLMSLMSCFLCSFFFIGLPNRAICVLQQITFGIVFTMAVSTVLAKTVTVvlaF 680
Cdd:cd15454    17 TTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYAITFLMIATPDTGICSFRRVFLGLGMCFSYAALLTKTNRI---H 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 681 KVTDPGRRlrnflVSGTPNYIIPICSL--------LQCVLCAIWLAVSPPFVDID------EHTLHGHIIIVCNKGSVTa 746
Cdd:cd15454    94 RIFEQGKK-----SVTAPKFISPASQLvitfslisVQLLGVFVWFAVDPPHTIVDygeqrtLDPEKARGVLKCDISDLS- 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 747 FYCILGYLACLALGNFSVAFLAKNLPDTFNEAKFLTFSMLVFCSVWVTFLPVYHSTKG---KHMVAVEIFSI-LASSAGI 822
Cdd:cd15454   168 LICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQsaeRMYIQTTTLTIsMSLSASV 247
                         250       260
                  ....*....|....*....|....*.
gi 1039778028 823 -LGCIFVPKIYIILMRPERNSTQKIR 847
Cdd:cd15454   248 sLGMLYMPKVYIIIFHPEQNVQKRKR 273
PBP1_taste_receptor cd06363
ligand-binding domain of the T1R taste receptor; Ligand-binding domain of the T1R taste ...
67-491 4.93e-24

ligand-binding domain of the T1R taste receptor; Ligand-binding domain of the T1R taste receptor. The T1R is a member of the family C receptors within the G-protein coupled receptor superfamily, which also includes the metabotropic glutamate receptors, GABAb receptors, the calcium-sensing receptor (CaSR), the V2R pheromone receptors, and a small group of uncharacterized orphan receptors.


Pssm-ID: 380586 [Multi-domain]  Cd Length: 418  Bit Score: 105.85  E-value: 4.93e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028  67 KTTKNHKYALALV--FAMDEINRNPDLLPNMsliiryTLG-----RC-DGKTVIPTPYLFRKKKESPIPNYfcneetmCS 138
Cdd:cd06363    35 DRFNLHGYHLAQAmrFAVEEINNSSDLLPGV------TLGyeifdTCsDAVNFRPTLSFLSQNGSHDIEVQ-------CN 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 139 YL--------LTGPH-WEVSLGFWKHMNSFLSPrilQLTYGPFHSIFSDDEQYPYLYQMAPKDTSLALAMVSFILYFSWN 209
Cdd:cd06363   102 YTnyqprvvaVIGPDsSELALTTAKLLGFFLMP---QISYGASSEELSNKLLYPSFLRTVPSDKYQVEAMVQLLQEFGWN 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 210 WIGLVIPDDDQGNQFLLELKKQSENKEICFAFVKMISVDDVSFPQNTEMyYNQIVMSSTNVIIIYG---ETYNFIDLIFR 286
Cdd:cd06363   179 WVAFLGSDDEYGQDGLQLFSEKAANTGICVAYQGLIPTDTDPKPKYQDI-LKKINQTKVNVVVVFApkqAAKAFFEEVIR 257
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 287 MwepPILQRIWI--TTKQLN-FPTRKKDI-SHGTFYGsltFLPHHGVISGFKNFVqtwfhlrntdlylvmqEWKYFnyed 362
Cdd:cd06363   258 Q---NLTGKVWIasEAWSLNdTVTSLPGIqSIGTVLG---FAIQTGTLPGFQEFI----------------YAFAF---- 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 363 sastckilknnssnasfdwlmeqkfdmtfsenshNIYNAVHAIAHALHemNLQQADNQAIDNGKGASSHCL-----KVNS 437
Cdd:cd06363   312 ----------------------------------SVYAAVYAVAHALH--NLLGCNSGACPKGRVVYPWQLleelkKVNF 355
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039778028 438 FL--RRIYFtNPPGDKVFmkqrvimhdEYDIVHFVNLSQHLGIKMkLGKFSPYLPH 491
Cdd:cd06363   356 TLlnQTIRF-DENGDPNF---------GYDIVQWIWNNSSWTFEV-VGSYSTYPIQ 400
PBP1_mGluR cd06362
ligand binding domain of metabotropic glutamate receptors (mGluR); Ligand binding domain of ...
74-470 2.30e-23

ligand binding domain of metabotropic glutamate receptors (mGluR); Ligand binding domain of the metabotropic glutamate receptors (mGluR), which are members of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into cellular responses. mGluRs bind to glutamate and function as an excitatory neurotransmitter; they are involved in learning, memory, anxiety, and the perception of pain. Eight subtypes of mGluRs have been cloned so far, and are classified into three groups according to their sequence similarities, transduction mechanisms, and pharmacological profiles. Group I is composed of mGlu1R and mGlu5R that both stimulate PLC hydrolysis. Group II includes mGlu2R and mGlu3R, which inhibit adenylyl cyclase, as do mGlu4R, mGlu6R, mGlu7R, and mGlu8R, which form group III.


Pssm-ID: 380585 [Multi-domain]  Cd Length: 460  Bit Score: 104.30  E-value: 2.30e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028  74 YALALVFAMDEINRNPDLLPNMSL--IIR-------YTLGRcdgkTVIPTPYLFRKKKESPipnyFCNEETMCSYLLTGP 144
Cdd:cd06362    32 RLEAMLFAIDEINSRPDLLPNITLgfVILddcssdtTALEQ----ALHFIRDSLLSQESAG----FCQCSDDPPNLDESF 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 145 HWE------------VSLgfwkHMNSFLSP-RILQLTYGPFHSIFSDDEQYPYLYQMAPKDTSLALAMVSFILYFSWNWI 211
Cdd:cd06362   104 QFYdvvgvigaesssVSI----QVANLLRLfKIPQISYASTSDELSDKERYPYFLRTVPSDSFQAKAIVDILLHFNWTYV 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 212 GLVIPDDDQGNQFLLELKKQSENKEICFAFVKMISVDDvsfpqnTEMYYNQIVMS-----STNVIIIY---GETYNFIDL 283
Cdd:cd06362   180 SVVYSEGSYGEEGYKAFKKLARKAGICIAESERISQDS------DEKDYDDVIQKllqkkNARVVVLFadqEDIRGLLRA 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 284 IFRMwepPILQR-IWITTKqlNFPTRKKDIsHGT---FYGSLTFLPHHGVISGFKNFVQT---WFHLRNtdlylvmqewK 356
Cdd:cd06362   254 AKRL---GASGRfIWLGSD--GWGTNIDDL-KGNedvALGALTVQPYSEEVPRFDDYFKSltpSNNTRN----------P 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 357 YFN-YEDSASTCKILKNNSSNASFDWLMEQKFDMTFSENS-HNIYNAVHAIAHALHEMNL---QQADNQAIDNGKGASSH 431
Cdd:cd06362   318 WFReFWQELFQCSFRPSRENSCNDDKLLINKSEGYKQESKvSFVIDAVYAFAHALHKMHKdlcPGDTGLCQDLMKCIDGS 397
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1039778028 432 CLKvnSFLRRIYFTNPPGDKV-FMKQRVIMhDEYDIVHFV 470
Cdd:cd06362   398 ELL--EYLLNVSFTGEAGGEIrFDENGDGP-GRYDIMNFQ 434
NCD3G pfam07562
Nine Cysteines Domain of family 3 GPCR; This conserved sequence contains several ...
512-565 3.83e-23

Nine Cysteines Domain of family 3 GPCR; This conserved sequence contains several highly-conserved Cys residues that are predicted to form disulphide bridges. It is predicted to lie outside the cell membrane, tethered to the pfam00003 in several receptor proteins.


Pssm-ID: 462210  Cd Length: 53  Bit Score: 93.09  E-value: 3.83e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1039778028 512 PSSVCSADCSPGFRRLWKEGMAACCFVCSPCPENEISNeTNMDQCVNCPEYQYA 565
Cdd:pfam07562   1 PSSVCSESCPPGQRKSQQGGAPVCCWDCVPCPEGEISN-TDSDTCKKCPEGQWP 53
7tmC_mGluR5 cd15450
metabotropic glutamate receptor 5 in group 1, member of the class C family of ...
601-835 4.02e-23

metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors; Group 1 mGluRs includes mGluR1 and mGluR5, as well as their closely related invertebrate receptors. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320566  Cd Length: 250  Bit Score: 99.29  E-value: 4.02e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 601 TAVVLCVFVKHHDTPIVKANNRSLSYLLLMSLMSCFLCSFFFIGLPNRAICVLQQITFGIVFTMAVSTVLAKT--VTVVL 678
Cdd:cd15450    17 TLFVTVIFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTnrIARIL 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 679 AFKVTDPGRRLRNFLVSGTPNYIIPICSLLQCVLCAIWLAVSPPFVDIDEHTLHgHIIIVCNKGSVtAFYCILGYLACLA 758
Cdd:cd15450    97 AGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIR-EVYLICNTTNL-GVVTPLGYNGLLI 174
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039778028 759 LGNFSVAFLAKNLPDTFNEAKFLTFSMLVFCSVWVTFLPVYHSTKGKhmVAVEIFSILASSAGILGCIFVPKIYIIL 835
Cdd:cd15450   175 LSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYK--IITMCFSVSLSATVALGCMFVPKVYIIL 249
7tmC_TAS1R2a-like cd15287
type 1 taste receptor subtype 2a and similar proteins, member of the class C of ...
589-835 1.73e-22

type 1 taste receptor subtype 2a and similar proteins, member of the class C of seven-transmembrane G protein-coupled receptors; This group includes TAS1R2a and its similar proteins found in fish. They are members of the type I taste receptor (TAS1R) family that belongs to the class C of G protein-coupled receptors. The functional TAS1Rs are obligatory heterodimers built from three known members, TAS1R1-3. TAS1R1 combines with TAS1R3 to form an umami taste receptor, which is responsible for the perception of savory taste, such as the food additive mono-sodium glutamate (MSG); whereas the combination of TAS1R2-TAS1R3 forms a sweet-taste receptor for sugars and D-amino acids. On the other hand, the type II taste receptors (TAS2Rs), which belong to the class A family of GPCRs, recognize bitter tasting compounds. In the case of sweet, for example, the TAS1R2-TAS1R3 heterodimer activates phospholipase C (PLC) via alpha-gustducin, a heterodimeric G protein that is involved in perception of sweet and bitter tastes. This activation leads to generation of inositol (1, 4, 5)-trisphosphate (IP3) and diacylglycerol (DAG), and consequently increases intracellular Ca2+ mobilization and activates a cation channel, TRPM5. In contrast to the TAS1R2-TAS1R3 heterodimer, TAS1R3 alone could activate adenylate cyclase leading to cAMP formation in the absence of alpha-gustducin. Each TAS1R contains a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD) and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B1, GPRC6A, mGlu, and TAS1R receptors.


Pssm-ID: 320414  Cd Length: 252  Bit Score: 97.45  E-value: 1.73e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 589 ALALM--AFCFSAFTAVVLCVFVKHHDTPIVKANNRSLSYLLLMSLMSCFLCSFFFIGLPNRAICVLQQITFGIVFTMAV 666
Cdd:cd15287     3 AILIMvgACVLVGLTLAVSVLFAINYNTPVVRSAGGPMCFLILGCLSLCSVSVFFYFGKPTVASCILRYFPFLLFYTVCL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 667 STVLAKTVTVVLAFKVTDPGRRLRNFLVSGTPNY-IIPICSLLQCVLCAIWLAVSPPFVDIDEHTLHGHIIIVC--NKGS 743
Cdd:cd15287    83 ACFVVRSFQIVCIFKIAAKFPKLHSWWVKYHGQWlLIAVAFVIQALLLITGFSFSPPKPYNDTSWYPDKIILSCdiNLKA 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 744 VTAFYCILGYLACLAlgnFSVAFLAKNLPDTFNEAKFLTFSMLVFCSVWVTFLPVYHSTKGKHMVAVEIFSILASSAGIL 823
Cdd:cd15287   163 TSMSLVLLLSLCCLC---FIFSYMGKDLPKNYNEAKAITFCLLLLILTWIIFATEYMLYRGKYIQLLNALAVLSSLYSFL 239
                         250
                  ....*....|..
gi 1039778028 824 GCIFVPKIYIIL 835
Cdd:cd15287   240 LWYFLPKCYIII 251
7tmC_mGluR1 cd15449
metabotropic glutamate receptor 1 in group 1, member of the class C family of ...
601-835 3.16e-21

metabotropic glutamate receptor 1 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors; Group 1 mGluRs includes mGluR1 and mGluR5, as well as their closely related invertebrate receptors. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320565  Cd Length: 250  Bit Score: 93.93  E-value: 3.16e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 601 TAVVLCVFVKHHDTPIVKANNRSLSYLLLMSLMSCFLCSFFFIGLPNRAICVLQQITFGIVFTMAVSTVLAKT--VTVVL 678
Cdd:cd15449    17 TMFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTnrIARIL 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 679 AFKVTDPGRRLRNFLVSGTPNYIIPICSLLQCVLCAIWLAVSPPfVDIDEHTLHGHIIIVCNKGSVtAFYCILGYLACLA 758
Cdd:cd15449    97 AGSKKKICTRKPRFMSAWAQVVIASILISVQLTLVVTLIIMEPP-MPILSYPSIKEVYLICNTSNL-GVVAPLGYNGLLI 174
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039778028 759 LGNFSVAFLAKNLPDTFNEAKFLTFSMLVFCSVWVTFLPVYHSTKGKhmVAVEIFSILASSAGILGCIFVPKIYIIL 835
Cdd:cd15449   175 MSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYK--IITTCFAVSLSVTVALGCMFTPKMYIII 249
PBP1_GPC6A-like cd06361
ligand-binding domain of the promiscuous L-alpha-amino acid receptor GPRC6A which is a ...
75-345 9.28e-20

ligand-binding domain of the promiscuous L-alpha-amino acid receptor GPRC6A which is a broad-spectrum amino acid-sensing receptor; This family includes the ligand-binding domain of the promiscuous L-alpha-amino acid receptor GPRC6A which is a broad-spectrum amino acid-sensing receptor, and its fish homolog, the 5.24 chemoreceptor. GPRC6A is a member of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into cellular responses.


Pssm-ID: 380584 [Multi-domain]  Cd Length: 401  Bit Score: 92.43  E-value: 9.28e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028  75 ALALVFAMDEINRNPdLLPNMSLIIRYtlgrCD-----GKTVIPTPYLFRkkkespiPNYFCNEETMCSY--------LL 141
Cdd:cd06361    38 SLAMIHAIEMINNST-LLPGIKLGYEI----YDtcsdvTKALQATLRLLS-------KFNSSNELLECDYtdyvppvkAV 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 142 TGPHW-EVSLGFWKHMNSFLSPrilQLTYGPFHSIFSDDEQYPYLYQMAPKDTSLALAMVSFILYFSWNWIGLVIPDDDQ 220
Cdd:cd06361   106 IGASYsEISIAVARLLNLQLIP---QISYESSAPILSDKLRFPSFLRTVPSDFHQTKAMAKLISHFGWNWVGIIYTDDDY 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 221 GNQFLLELKKQSENKEICFAFVKMI--SVDDVSFPQNTEMYYNQIVMSST-NVIIIYGETYNFIDLIFRMWEPPIlQRIW 297
Cdd:cd06361   183 GRSALESFIIQAEAENVCIAFKEVLpaYLSDPTMNVRINDTIQTIQSSSQvNVVVLFLKPSLVKKLFKEVIERNI-SKIW 261
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1039778028 298 ITTKqlNFPTRK-----KDISH-GTFYGsLTFlpHHGVISGFKNFVQTWFHLRN 345
Cdd:cd06361   262 IASD--NWSTAReilkmPNINKvGKILG-FTF--KSGNISSFHNYLKNLLIYSI 310
ANF_receptor pfam01094
Receptor family ligand binding region; This family includes extracellular ligand binding ...
75-423 3.78e-18

Receptor family ligand binding region; This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure.


Pssm-ID: 460062 [Multi-domain]  Cd Length: 347  Bit Score: 86.67  E-value: 3.78e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028  75 ALALVFAMDEINRNPDLLPN--MSLIIRYTlgRCDGKTVIPTPYLFRKKKESPIPNYFCNEE-TMCSYLLTgpHWEVSlg 151
Cdd:pfam01094   3 LLAVRLAVEDINADPGLLPGtkLEYIILDT--CCDPSLALAAALDLLKGEVVAIIGPSCSSVaSAVASLAN--EWKVP-- 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 152 fwkhmnsflsprilQLTYGPFHSIFSDDEQYPYLYQMAPKDTSLALAMVSFILYFSWNWIGLVIPDDDQGNQFLLELKKQ 231
Cdd:pfam01094  77 --------------LISYGSTSPALSDLNRYPTFLRTTPSDTSQADAIVDILKHFGWKRVALIYSDDDYGESGLQALEDA 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 232 SENKEICFAFVKMISVDDvSFPQNTEMYYNQIVMSSTnVIII--YGET-YNFIDLI--------FRMWeppILQRIWITT 300
Cdd:pfam01094 143 LRERGIRVAYKAVIPPAQ-DDDEIARKLLKEVKSRAR-VIVVccSSETaRRLLKAArelgmmgeGYVW---IATDGLTTS 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 301 KQLNFPTRKKdishgTFYGSLTFLPHHGVISGFKNFVQTWFHLRNTDLylvmqewkyfnyedsastckilknnssnasfd 380
Cdd:pfam01094 218 LVILNPSTLE-----AAGGVLGFRLHPPDSPEFSEFFWEKLSDEKELY-------------------------------- 260
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1039778028 381 wLMEQKFDMTFSEnshNIYNAVHAIAHALHEMNLQQADNQAID 423
Cdd:pfam01094 261 -ENLGGLPVSYGA---LAYDAVYLLAHALHNLLRDDKPGRACG 299
7tmC_TAS1R2 cd15288
type 1 taste receptor subtype 2, member of the class C of seven-transmembrane G ...
585-835 2.38e-12

type 1 taste receptor subtype 2, member of the class C of seven-transmembrane G protein-coupled receptors; This group represents TAS1R2, which is a member of the type I taste receptor (TAS1R) family that belongs to the class C of G protein-coupled receptors. The functional TAS1Rs are obligatory heterodimers built from three known members, TAS1R1-3. TAS1R1 combines with TAS1R3 to form an umami taste receptor, which is responsible for the perception of savory taste, such as the food additive mono-sodium glutamate (MSG); whereas the combination of TAS1R2-TAS1R3 forms a sweet-taste receptor for sugars and D-amino acids. On the other hand, the type II taste receptors (TAS2Rs), which belong to the class A family of GPCRs, recognize bitter tasting compounds. In the case of sweet, for example, the TAS1R2-TAS1R3 heterodimer activates phospholipase C (PLC) via alpha-gustducin, a heterodimeric G protein that is involved in perception of sweet and bitter tastes. This activation leads to generation of inositol (1, 4, 5)-trisphosphate (IP3) and diacylglycerol (DAG), and consequently increases intracellular Ca2+ mobilization and activates a cation channel, TRPM5. In contrast to the TAS1R2-TAS1R3 heterodimer, TAS1R3 alone could activate adenylate cyclase leading to cAMP formation in the absence of alpha-gustducin. Each TAS1R contains a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD) and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B1, GPRC6A, mGlu, and TAS1R receptors.


Pssm-ID: 320415  Cd Length: 254  Bit Score: 67.89  E-value: 2.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 585 PLGMALALMAFCFSAFTAVVLCVFVKHHDTPIVKANNRSLSYLLLMSLMSCFLCSFFFIGLPNRAICVLQQITFGIVFTM 664
Cdd:cd15288     1 GPTIVVALLAALGFLSTLAILVIFGRHFQTPVVRSAGGRMCFLMLAPLLVAYVNVPVYVGIPTVFTCLCRQTLFPLCFTV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 665 AVSTVLAKTVTVVLAFKVTDPGRRLRNFLVSGTPNYI-IPICSLLQCVLCAIWLAVSPPFVDIDEHTLHGHIIIV-CNKG 742
Cdd:cd15288    81 CISCIAVRSFQIVCIFKMARRLPRAYSYWVKYNGPYVfVALITLLKVVIVVINVLAHPTAPTTRADPDDPQVMILqCNPN 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 743 SVTAFYCILGYLACLALGNFSVAFLAKNLPDTFNEAKFLTFSMLVFCSVWV---TFLPVYHStkgkhmVAVEIFSILASS 819
Cdd:cd15288   161 YRLALLFNTSLDLLLSVLGFCFAYMGKELPTNYNEAKFITLCMTFYFASSVflcTFMSVYEG------VLVTIFDALVTV 234
                         250
                  ....*....|....*....
gi 1039778028 820 AGILGC---IFVPKIYIIL 835
Cdd:cd15288   235 INLLGIslgYFGPKCYMIL 253
PBP1_glutamate_receptors-like cd06269
ligand-binding domain of family C G-protein couples receptors (GPCRs), membrane bound guanylyl ...
77-273 6.27e-11

ligand-binding domain of family C G-protein couples receptors (GPCRs), membrane bound guanylyl cyclases such as natriuretic peptide receptors (NPRs), and N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of ionotropic glutamate rece; This CD represents the ligand-binding domain of the family C G-protein couples receptors (GPCRs), membrane bound guanylyl cyclases such as the family of natriuretic peptide receptors (NPRs), and the N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the ionotropic glutamate receptors, all of which are structurally similar and related to the periplasmic-binding fold type 1 family. The family C GPCRs consists of metabotropic glutamate receptor (mGluR), a calcium-sensing receptor (CaSR), gamma-aminobutyric acid receptor (GABAbR), the promiscuous L-alpha-amino acid receptor GPR6A, families of taste and pheromone receptors, and orphan receptors. Truncated splicing variants of the orphan receptors are not included in this CD. The family C GPCRs are activated by endogenous agonists such as amino acids, ions, and sugar based molecules. Their amino terminal ligand-binding region is homologous to the bacterial leucine-isoleucine-valine binding protein (LIVBP) and a leucine binding protein (LBP). The ionotropic glutamate receptors (iGluRs) have an integral ion channel and are subdivided into three major groups based on their pharmacology and structural similarities: NMDA receptors, AMPA receptors, and kainate receptors. The family of membrane bound guanylyl cyclases is further divided into three subfamilies: the ANP receptor (GC-A)/C-type natriuretic peptide receptor (GC-B), the heat-stable enterotoxin receptor (GC-C)/sensory organ specific membrane GCs such as retinal receptors (GC-E, GC-F), and olfactory receptors (GC-D and GC-G).


Pssm-ID: 380493 [Multi-domain]  Cd Length: 332  Bit Score: 64.75  E-value: 6.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028  77 ALVFAMDEINRNPDLLPNMSLIIRYTLGRCDGkTVIPTPYLFRKKKESPipnyfcneetmcsYLLTGPHWEVS------- 149
Cdd:cd06269    21 AFELALSDVNSRPDLLPKTTLGLAIRDSECNP-TQALLSACDLLAAAKV-------------VAILGPGCSASaapvanl 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 150 LGFWkhmnsflspRILQLTYGPFHSIFSDDEQYPYLYQMAPKDTSLALAMVSFILYFSWNWIGLVIPDDDQGNQFLLELK 229
Cdd:cd06269    87 ARHW---------DIPVLSYGATAPGLSDKSRYAYFLRTVPPDSKQADAMLALVRRLGWNKVVLIYSDDEYGEFGLEGLE 157
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1039778028 230 KQSENKEICFAFVkmisvddVSFPQNTEMYYNQIVM----SSTNVIII 273
Cdd:cd06269   158 ELFQEKGGLITSR-------QSFDENKDDDLTKLLRnlrdTEARVIIL 198
7tmC_GABA-B-like cd15047
gamma-aminobutyric acid type B receptor and related proteins, member of the class C family of ...
635-834 4.48e-09

gamma-aminobutyric acid type B receptor and related proteins, member of the class C family of seven-transmembrane G protein-coupled receptors; The type B receptor for gamma-aminobutyric acid, GABA-B, is activated by its endogenous ligand GABA, the principal inhibitory neurotransmitter. The functional GABA-B receptor is an obligatory heterodimer composed of two related subunits, GABA-B1, which is primarily involved in GABA ligand binding, and GABA-B2, which is responsible for both G-protein coupling and trafficking of the heterodimer to the plasma membrane. Activation of GABA-B couples to G(i/o)-type G proteins, which in turn modulate three major downstream effectors: adenylate cyclase, voltage-sensitive Ca2+ channels, and inwardly-rectifying K+ channels. Consequently, GABA-B receptor produces slow and sustained inhibitory responses by decreased neurotransmitter release via inhibition of Ca2+ channels and by postsynaptic hyperpolarization via the activation of K+ channels through the G-protein beta-gamma dimer. The GABA-B is expressed in both pre- and postsynaptic sites of glutamatergic and GABAergic neurons in the brain where it regulates synaptic activity. Thus, the GABA-B receptor agonist, baclofen, is used to treat muscle tightness and cramping caused by spasticity in multiple sclerosis patients. Moreover, GABA-B antagonists improves cognitive performance in mammals, while GABA-B agonists suppress cognitive behavior. In most of the class C family members, the extracellular Venus-flytrap domain in the N-terminus is connected to the seven-transmembrane (7TM) via a cysteine-rich domain (CRD). However, in the GABA-B receptor, the CRD is absent in both subunits and the Venus-flytrap ligand-binding domain is directly connected to the 7TM via a 10-15 amino acids linker, suggesting that GABA-B receptor may utilize a different activation mechanism. Also included in this group are orphan receptors, GPR156 and GPR158, which are closely related to the GABA-B receptor family.


Pssm-ID: 320175  Cd Length: 263  Bit Score: 58.34  E-value: 4.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 635 CFLCS----FFFI--GLPNRAICVLQQITFGIVFTMAVSTVLAKTVTVVLAFkvTDPGRRLRNFlvsgTPNYIIPICSLL 708
Cdd:cd15047    48 CILCYisviLFGLddSKPSSFLCTARPWLLSIGFTLVFGALFAKTWRIYRIF--TNKKLKRIVI----KDKQLLKIVGIL 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 709 ---QCVLCAIWLAVSPP-------FVDIDEHTLHGHIIIVC-NKGSVTAFYCILGYLAC-LALGNFsVAFLAKNLPDT-F 775
Cdd:cd15047   122 lliDIIILILWTIVDPLkptrvlvLSEISDDVKYEYVVHCCsSSNGIIWLGILLAYKGLlLLFGCF-LAWKTRNVDIEeF 200
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039778028 776 NEAKFLTFSM--LVFCSVWVTFLPVYHSTKGKHMVAVEIFSILASSAGILGCIFVPKIYII 834
Cdd:cd15047   201 NESKYIGISIynVLFLSVIGVPLSFVLTDSPDTSYLIISAAILFCTTATLCLLFVPKFWLL 261
PBP1_GABAb_receptor cd06366
ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for ...
80-214 3.79e-08

ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA); Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA). GABA is the major inhibitory neurotransmitter in the mammalian CNS and, like glutamate and other transmitters, acts via both ligand gated ion channels (GABAa receptors) and G-protein coupled receptors (GABAb receptor or GABAbR). GABAa receptors are members of the ionotropic receptor superfamily which includes alpha-adrenergic and glycine receptors. The GABAb receptor is a member of a receptor superfamily which includes the mGlu receptors. The GABAb receptor is coupled to G alpha-i proteins, and activation causes a decrease in calcium, an increase in potassium membrane conductance, and inhibition of cAMP formation. The response is thus inhibitory and leads to hyperpolarization and decreased neurotransmitter release, for example.


Pssm-ID: 380589 [Multi-domain]  Cd Length: 404  Bit Score: 56.48  E-value: 3.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028  80 FAMDEINRNPDLLPNMSLIIRYTLGRCDGKTVIPT--PYLFRKKKESPIPNYFCNEETMcsylltgPHWEVSlgfwKHMN 157
Cdd:cd06366    26 MALEHINNRSDILPGYNLELIWNDTQCDPGLGLKAlyDLLYTPPPKVMLLGPGCSSVTE-------PVAEAS----KYWN 94
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039778028 158 sflsprILQLTYGPFHSIFSDDEQYPYLYQMAPKDTSLALAMVSFILYFSWNWIGLV 214
Cdd:cd06366    95 ------LVQLSYAATSPALSDRKRYPYFFRTVPSDTAFNPARIALLKHFGWKRVATI 145
PBP1_mGluR_groupII cd06375
ligand binding domain of the group II metabotropic glutamate receptor; Ligand binding domain ...
77-240 2.72e-07

ligand binding domain of the group II metabotropic glutamate receptor; Ligand binding domain of the group II metabotropic glutamate receptor, a family that contains mGlu2R and mGlu3R, all of which inhibit adenylyl cyclase. The metabotropic glutamate receptor is a member of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into intracellular responses. The mGluRs are classified into three groups which comprise eight subtypes


Pssm-ID: 380598 [Multi-domain]  Cd Length: 462  Bit Score: 54.06  E-value: 2.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028  77 ALVFAMDEINRNPDLLPNMSL--------------------IIRYTLGRCD-GKTVIPTPYLFRKKKESPIPnyfcneet 135
Cdd:cd06375    39 AMLFAIDRINRDPHLLPGVRLgvhildtcsrdtyaleqsleFVRASLTKVDdSEYMCPDDGSYAIQEDSPLP-------- 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 136 mCSYLLTGPHWEVSLGFWKHMNSFlspRILQLTYGPFHSIFSDDEQYPYLYQMAPKDTSLALAMVSFILYFSWNWIGLVI 215
Cdd:cd06375   111 -IAGVIGGSYSSVSIQVANLLRLF---QIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVA 186
                         170       180
                  ....*....|....*....|....*
gi 1039778028 216 PDDDQGNQFLLELKKQSENKEICFA 240
Cdd:cd06375   187 SEGDYGETGIEAFEQEARLRNICIA 211
PBP1_SAP_GC-like cd06370
Ligand-binding domain of membrane bound guanylyl cyclases; Ligand-binding domain of membrane ...
72-426 1.32e-06

Ligand-binding domain of membrane bound guanylyl cyclases; Ligand-binding domain of membrane bound guanylyl cyclases (GCs), which are known to be activated by sperm-activating peptides (SAPs), such as speract or resact. These ligand peptides are released by a range of invertebrates to stimulate the metabolism and motility of spermatozoa and are also potent chemoattractants. These GCs contain a single transmembrane segment, an extracellular ligand binding domain, and intracellular protein kinase-like and cyclase catalytic domains. GCs of insect and nematodes, which exhibit high sequence similarity to the speract receptor are also included in this model.


Pssm-ID: 380593 [Multi-domain]  Cd Length: 400  Bit Score: 51.48  E-value: 1.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028  72 HKYALALVFAMDEINRNPDLLPNMSLIIRYTLGRCDGKTVIPTPYLFRKKKESPI--PNYFCN-EETMCSylltgphwev 148
Cdd:cd06370    20 RVISGAITLAVDDVNNDPNLLPGHTLSFVWNDTRCDELLSIRAMTELWKRGVSAFigPGCTCAtEARLAA---------- 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 149 slgfwkhmnSFLSPRIlqlTYGPFHSIFSDDEQYPYLYQMAPKDTSLALAMVSFILYFSWNWIGLVIPDDDQGNQFLLEL 228
Cdd:cd06370    90 ---------AFNLPMI---SYKCADPEVSDKSLYPTFARTIPPDSQISKSVIALLKHFNWNKVSIVYENETKWSKIADTI 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 229 KKQSENKEICFAFVKMISvDDVSFPQNTEMYYNQIVMSS---TNVIIIYGETYNFIDLIFRMWEPPILQR-----IWITT 300
Cdd:cd06370   158 KELLELNNIEINHEEYFP-DPYPYTTSHGNPFDKIVEETkekTRIYVFLGDYSLLREFMYYAEDLGLLDNgdyvvIGVEL 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 301 KQLNFPTRKKDISHGTFYgsLTFLPHHGVISGFKNFvqtwfhlrntdLYLVMQEWKYFNYEdsaSTCKILKNNSSNASF- 379
Cdd:cd06370   237 DQYDVDDPAKYPNFLSGD--YTKNDTKEALEAFRSV-----------LIVTPSPPTNPEYE---KFTKKVKEYNKLPPFn 300
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1039778028 380 -DWLMEQKFDMTFSENSHNIYNAVHAIAHALHEMnlqQADNQAIDNGK 426
Cdd:cd06370   301 fPNPEGIEKTKEVPIYAAYLYDAVMLYARALNET---LAEGGDPRDGT 345
7tmC_GPR158-like cd15293
orphan GPR158 and similar proteins, member of the class C family of seven-transmembrane G ...
646-836 1.19e-05

orphan GPR158 and similar proteins, member of the class C family of seven-transmembrane G protein-coupled receptors; This group includes orphan receptors GPR158, GPR158-like (also called GPR179) and similar proteins. These orphan receptors are closely related to the type B receptor for gamma-aminobutyric acid (GABA-B), which is activated by its endogenous ligand GABA, the principal inhibitory neurotransmitter. The functional GABA-B receptor is an obligatory heterodimer composed of two related subunits, GABA-B1, which is primarily involved in GABA ligand binding, and GABA-B2, which is responsible for both G-protein coupling and trafficking of the heterodimer to the plasma membrane. Activation of GABA-B couples to G(i/o)-type G proteins, which in turn modulate three major downstream effectors: adenylate cyclase, voltage-sensitive Ca2+ channels, and inwardly-rectifying K+ channels. Consequently, GABA-B receptor produces slow and sustained inhibitory responses by decreased neurotransmitter release via inhibition of Ca2+ channels and by postsynaptic hyperpolarization via the activation of K+ channels through the G-protein beta-gamma dimer. The GABA-B is expressed in both pre- and postsynaptic sites of glutamatergic and GABAergic neurons in the brain where it regulates synaptic activity. Thus, the GABA-B receptor agonist, baclofen, is used to treat muscle tightness and cramping caused by spasticity in multiple sclerosis patients. Moreover, GABA-B antagonists improves cognitive performance in mammals, while GABA-B agonists suppress cognitive behavior. In most of the class C family members, the extracellular Venus-flytrap domain in the N-terminus is connected to the seven-transmembrane (7TM) via a cysteine-rich domain (CRD). However, in the GABA-B receptor, the CRD is absent in both subunits and the Venus-flytrap ligand-binding domain is directly connected to the 7TM via a 10-15 amino acids linker, suggesting that GABA-B receptor may utilize a different activation mechanism.


Pssm-ID: 320420  Cd Length: 252  Bit Score: 47.59  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 646 PNRAICVLQQITFGIVFTMAVSTVLAKTVTVVLAFKV-TDPGRRLRNflvSGTPNYIIPICsLLQCVLCAIWLAVSPPFV 724
Cdd:cd15293    62 PSVFRCILRPWFRHLGFAIVYGALILKTYRILVVFRSrSARRVHLTD---RDLLKRLGLIV-LVVLGYLAAWTAVNPPNV 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 725 DIDEHTLHGHIII-VCNkgSVTAFYCILGYLACLALGNFSVAFLAKNLPDTFNEAKFLTFSMLVFCSVWVTFLPVYHSTK 803
Cdd:cd15293   138 EVGLTLTSSGLKFnVCS--LDWWDYVMAIAELLFLLWGVYLCYAVRKAPSAFNESRYISLAIYNELLLSVIFNIIRFFLL 215
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1039778028 804 GK----HMVAVEIFSILASSAGILGCIFVPKIYIILM 836
Cdd:cd15293   216 PSlhpdLLFLLFFLHTQLTVTVTLLLIFGPKFYLVLR 252
PBP1_mGluR_groupI cd06374
ligand binding domain of the group I metabotropic glutamate receptor; Ligand binding domain of ...
77-485 1.80e-05

ligand binding domain of the group I metabotropic glutamate receptor; Ligand binding domain of the group I metabotropic glutamate receptor, a family containing mGlu1R and mGlu5R, all of which stimulate phospholipase C (PLC) hydrolysis. The metabotropic glutamate receptor is a member of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into intracellular responses. The mGluRs are classified into three groups which comprise eight subtypes.


Pssm-ID: 380597 [Multi-domain]  Cd Length: 474  Bit Score: 48.11  E-value: 1.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028  77 ALVFAMDEINRNPDLLPNMSL--IIRYTlgrCDGKTViPTPYLFRKKKESPIPNYFCNEETMCSYLLTGPHWEVSlgfwK 154
Cdd:cd06374    46 AMFRTLDKINKDPNLLPNITLgiEIRDS---CWYSPV-ALEQSIEFIRDSVASVEDEKDTQNTPDPTPLSPPENR----K 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 155 HMNSFLSP----------------RILQLTYGPFHSIFSDDEQYPYLYQMAPKDTSLALAMVSFILYFSWNWIGLVIPDD 218
Cdd:cd06374   118 PIVGVIGPgsssvtiqvqnllqlfHIPQIGYSATSIDLSDKSLYKYFLRVVPSDYLQARAMLDIVKRYNWTYVSTVHTEG 197
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 219 DQGNQFLLELKKQSENKEICFAfvkmisvddvsfpQNTEMYYNqivmsstnviiiyGETYNFIDLIFRMWEPPILQRIWI 298
Cdd:cd06374   198 NYGESGIEAFKELAAEEGICIA-------------HSDKIYSN-------------AGEEEFDRLLRKLMNTPNKARVVV 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 299 ------TTKQLNFPTRKKDISHG-TFYGSLTFLPHHGVISGFKNFVQTWFHLRNTDLYLVMQEWKYFNYEdsastckiLK 371
Cdd:cd06374   252 cfcegeTVRGLLKAMRRLNATGHfLLIGSDGWADRKDVVEGYEDEAAGGITIKIHSPEVESFDEYYFNLK--------PE 323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 372 NNSSNASFDWLMEQKFDMTF-----------------SENSHNIY---------NAVHAIAHALHEMnlqqadnQAIDNG 425
Cdd:cd06374   324 TNSRNPWFREFWQHRFDCRLpghpdenpyfkkcctgeESLLGNYVqdsklgfviNAIYAMAHALHRM-------QEDLCG 396
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039778028 426 KGASSHC---LKVN-----SFLRRIYFTNPPGDKVFMKQRVIMHDEYDIVHFVNLSQHLGIKMKLGKF 485
Cdd:cd06374   397 GYSVGLCpamLPINgslllDYLLNVSFVGVSGDTIMFDENGDPPGRYDIMNFQKTGEGSYDYVQVGSW 464
PBP1_ABC_transporter_GPCR_C-like cd04509
Family C of G-protein coupled receptors and their close homologs, the type 1 ...
77-241 6.53e-05

Family C of G-protein coupled receptors and their close homologs, the type 1 periplasmic-binding proteins of ATP-binding cassette transporter-like systems; This CD includes members of the family C of G-protein coupled receptors and their close homologs, the type 1 periplasmic-binding proteins of ATP-binding cassette transporter-like systems. The family C GPCR includes glutamate/glycine-gated ion channels such as the NMDA receptor, G-protein-coupled receptors, metabotropic glutamate, GABA-B, calcium sensing, pheromone receptors, and atrial natriuretic peptide-guanylate cyclase receptors. The glutamate receptors that form cation-selective ion channels, iGluR, can be classified into three different subgroups according to their binding-affinity for the agonists NMDA (N-methyl-D-asparate), AMPA (alpha-amino-3-dihydro-5-methyl-3-oxo-4-isoxazolepropionic acid), and kainate. L-glutamate is a major neurotransmitter in the brain of vertebrates and acts through either mGluRs or iGluRs. mGluRs subunits possess seven transmembrane segments and a large N-terminal extracellular domain. ABC-type leucine-isoleucine-valine binding protein (LIVBP) is a bacterial periplasmic binding protein that has homology with the amino-terminal domain of the glutamate-receptor ion channels (iGluRs). The extracellular regions of iGluRs are made of two PBP-like domains in tandem, a LIVBP-like domain that constitutes the N terminus (included in this model) followed by a domain related to lysine-arginine-ornithine-binding protein (LAOBP) that belongs to the type 2 periplasmic binding fold protein superfamily. The uncharacterized periplasmic components of various ABC-type transport systems are also included in this family.


Pssm-ID: 380490  Cd Length: 306  Bit Score: 45.76  E-value: 6.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028  77 ALVFAMDEINRNPDLLPNMSLIIRYTLGRCDGKTVIPTPYLF-RKKKESPIPNYFCNEETmcsyLLTGPHWEVSLGFWKH 155
Cdd:cd04509    32 AMEQALDDINADPNLLPNNTLGIVIYDDCCDPKQALEQSNKFvNDLIQKDTSDVRCTNGE----PPVFVKPEGIKGVIGH 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 156 MNSFLSPR---------ILQLTYGPFHSIFSDDEQYPYLYQMAPKDTSLALAMVSFILYFSWNWIGLVIPDDDQGNQFLL 226
Cdd:cd04509   108 LCSSVTIPvsnilelfgIPQITYAATAPELSDDRGYQLFLRVVPLDSDQAPAMADIVKEKVWQYVSIVHDEGQYGEGGAR 187
                         170
                  ....*....|....*
gi 1039778028 227 ELKKQSENKEICFAF 241
Cdd:cd04509   188 AFQDGLKKGGLCIAF 202
PBP1_NPR_GC-like cd06352
ligand-binding domain of membrane guanylyl-cyclase receptors; Ligand-binding domain of ...
81-273 1.18e-04

ligand-binding domain of membrane guanylyl-cyclase receptors; Ligand-binding domain of membrane guanylyl-cyclase receptors. Membrane guanylyl cyclases (GC) have a single membrane-spanning region and are activated by endogenous and exogenous peptides. This family can be divided into three major subfamilies: the natriuretic peptide receptors (NPRs), sensory organ-specific membrane GCs, and the enterotoxin/guanylin receptors. The binding of peptide ligands to the receptor results in the activation of the cytosolic catalytic domain. Three types of NPRs have been cloned from mammalian tissues: NPR-A/GC-A, NPR-B/ GC-B, and NPR-C. In addition, two of the GCs, GC-D and GC-G, appear to be pseudogenes in humans. Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are produced in the heart, and both bind to the NPR-A. NPR-C, also termed the clearance receptor, binds each of the natriuretic peptides and can alter circulating levels of these peptides. The ligand binding domain of the NPRs exhibits strong structural similarity to the type 1 periplasmic binding fold protein family.


Pssm-ID: 380575 [Multi-domain]  Cd Length: 391  Bit Score: 45.42  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028  81 AMDEINRNPDLLPNMSLIIRYTLGRCDGKTVIPTPYLFRKKKEspiPNYF----CNEETMCSYLLTGphwevslgFWKhm 156
Cdd:cd06352    27 AIERINSEGLLLPGFNFEFTYRDSCCDESEAVGAAADLIYKRN---VDVFigpaCSAAADAVGRLAT--------YWN-- 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039778028 157 nsflsprILQLTYGPFHSIFSDDEQYPYLYQMAPKDTSLALAMVSFILYFSWNWIGLVIPDDDQGNQFL---LELKKQSE 233
Cdd:cd06352    94 -------IPIITWGAVSASFLDKSRYPTLTRTSPNSLSLAEALLALLKQFNWKRAAIIYSDDDSKCFSIandLEDALNQE 166
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1039778028 234 NKEICFAFVKMISVDDVSFpqnTEMYynQIVMSSTNVIII 273
Cdd:cd06352   167 DNLTISYYEFVEVNSDSDY---SSIL--QEAKKRARIIVL 201
PBP1_GABAb_receptor_plant cd19990
periplasmic ligand-binding domain of Arabidopsis thaliana glutamate receptors and its close ...
181-230 4.79e-03

periplasmic ligand-binding domain of Arabidopsis thaliana glutamate receptors and its close homologs in other plants; This group includes the ligand-binding domain of Arabidopsis thaliana glutamate receptors, which have sequence similarity with animal ionotropic glutamate receptor and its close homologs in other plants. The ligand-binding domain of GABAb receptors are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA). GABA is the major inhibitory neurotransmitter in the mammalian CNS and, like glutamate and other transmitters, acts via both ligand gated ion channels (GABAa receptors) and G-protein coupled receptors (GABAb receptor or GABAbR). GABAa receptors are members of the ionotropic receptor superfamily which includes alpha-adrenergic and glycine receptors. The GABAb receptor is a member of a receptor superfamily which includes the mGlu receptors. The GABAb receptor is coupled to G alpha-i proteins, and activation causes a decrease in calcium, an increase in potassium membrane conductance, and inhibition of cAMP formation. The response is thus inhibitory and leads to hyperpolarization and decreased neurotransmitter release, for example.


Pssm-ID: 380645 [Multi-domain]  Cd Length: 373  Bit Score: 40.29  E-value: 4.79e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1039778028 181 QYPYLYQMAPKDTSLALAMVSFILYFSWNWIGLVIPDDDQGNQFLLELKK 230
Cdd:cd19990   105 RWPFFIRMTHNDSSQMKAIAAIVQSYGWRRVVLIYEDDDYGSGIIPYLSD 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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