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Conserved domains on  [gi|1039776046|ref|XP_017177317|]
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MICOS complex subunit Mic60 isoform X3 [Mus musculus]

Protein Classification

MICOS complex subunit MIC60( domain architecture ID 12101363)

MICOS complex subunit MIC60 is a component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 43-701 0e+00

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


:

Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 585.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  43 AGKIAGAGLLFVGGGIGGTILYAKWDSHFRESVEKTIPYSDKLFGMVLGSAPYTVPlpkKPVQSGPLKISSVSEVMKDSK 122
Cdd:pfam09731   4 FGKFFVALVLIVGVGYGGVVLYAYKDDNFRDFFEEYIPYGEEVVLYALGEDPPLAP---KPKTFRPLQPSVVSAVTGESK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 123 LPVAQSQKTKGDTPASAG-DTLSVPAPAVQHEDTIKTECPNTNEGKSTsettALAKSLEDALNRTSSVTLQTITAQNAAV 201
Cdd:pfam09731  81 EPKEEKKQVKIPRQSGVSsEVAEEEKEATKDAAEAKAQLPKSEQEKEK----ALEEVLKEAISKAESATAVAKEAKDDAI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 202 QAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALKErrkavdeaadallkakeeleKMKTIIEDAKKREIAGATPHITA 281
Cdd:pfam09731 157 QAVKAHTDSLKEASDTAEISREKATDSALQKAEALAE--------------------KLKEVINLAKQSEEEAAPPLLDA 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 282 AEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSITPDITPGWKGMSisdlagKLSTDDLNSLIA 361
Cdd:pfam09731 217 APETPPKLPEHLDNVEEKVEKAQSLAKLVDQYKELVASERIVFQQELVSIFPDIIPVLKEDN------LLSNDDLNSLIA 290

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 362 HAHRRIDQLNRELAQQKATEKQHIELALEKHKlEEKRTFDSAVAKALEHHRS----EIQAEQDRKVEEVRDAMENEMRTQ 437
Cdd:pfam09731 291 HAHREIDQLSKKLAELKKREEKHIERALEKQK-EELDKLAEELSARLEEVRAadeaQLRLEFEREREEIRESYEEKLRTE 369

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 438 LRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSEKLSEQElefrrrsqeqmDSFTLDINTAYARLRGIEQAVQSHAVAEEE 517
Cdd:pfam09731 370 LERQAEAHEEHLKDVLVEQEIELQREFLQDIKEKVEEER-----------AGRLLKLNELLANLKGLEKATSSHSEVEDE 438

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 518 ARKAHQLWLSVEALKYSMKTSSAEMPTIPLGSAVEAIRVNCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLA 597
Cdd:pfam09731 439 NRKAQQLWLAVEALRSTLEDGSADSRPRPLVRELKALKELASDDEVVKAALASLPEEAYQRGVYTEAALRERFRRVAKEV 518

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 598 RRVAMIDETRNSLYQYFLSYLQSLLLFPPKQlkppAELYPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQ 677
Cdd:pfam09731 519 RKVSLIDPEGAGLLSHALSYLLSKLMFKPKQ----GEADPAGDDVESILARAEYYLEEGDLDSAAREMNSLKGWSKKLAS 594

                         650       660
                  ....*....|....*....|....
gi 1039776046 678 DWLKEARMTLETKQIVEILTAYAS 701
Cdd:pfam09731 595 DWLKEARRRLEVQQALELLQAEAA 618
 
Name Accession Description Interval E-value
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 43-701 0e+00

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 585.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  43 AGKIAGAGLLFVGGGIGGTILYAKWDSHFRESVEKTIPYSDKLFGMVLGSAPYTVPlpkKPVQSGPLKISSVSEVMKDSK 122
Cdd:pfam09731   4 FGKFFVALVLIVGVGYGGVVLYAYKDDNFRDFFEEYIPYGEEVVLYALGEDPPLAP---KPKTFRPLQPSVVSAVTGESK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 123 LPVAQSQKTKGDTPASAG-DTLSVPAPAVQHEDTIKTECPNTNEGKSTsettALAKSLEDALNRTSSVTLQTITAQNAAV 201
Cdd:pfam09731  81 EPKEEKKQVKIPRQSGVSsEVAEEEKEATKDAAEAKAQLPKSEQEKEK----ALEEVLKEAISKAESATAVAKEAKDDAI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 202 QAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALKErrkavdeaadallkakeeleKMKTIIEDAKKREIAGATPHITA 281
Cdd:pfam09731 157 QAVKAHTDSLKEASDTAEISREKATDSALQKAEALAE--------------------KLKEVINLAKQSEEEAAPPLLDA 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 282 AEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSITPDITPGWKGMSisdlagKLSTDDLNSLIA 361
Cdd:pfam09731 217 APETPPKLPEHLDNVEEKVEKAQSLAKLVDQYKELVASERIVFQQELVSIFPDIIPVLKEDN------LLSNDDLNSLIA 290

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 362 HAHRRIDQLNRELAQQKATEKQHIELALEKHKlEEKRTFDSAVAKALEHHRS----EIQAEQDRKVEEVRDAMENEMRTQ 437
Cdd:pfam09731 291 HAHREIDQLSKKLAELKKREEKHIERALEKQK-EELDKLAEELSARLEEVRAadeaQLRLEFEREREEIRESYEEKLRTE 369

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 438 LRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSEKLSEQElefrrrsqeqmDSFTLDINTAYARLRGIEQAVQSHAVAEEE 517
Cdd:pfam09731 370 LERQAEAHEEHLKDVLVEQEIELQREFLQDIKEKVEEER-----------AGRLLKLNELLANLKGLEKATSSHSEVEDE 438

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 518 ARKAHQLWLSVEALKYSMKTSSAEMPTIPLGSAVEAIRVNCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLA 597
Cdd:pfam09731 439 NRKAQQLWLAVEALRSTLEDGSADSRPRPLVRELKALKELASDDEVVKAALASLPEEAYQRGVYTEAALRERFRRVAKEV 518

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 598 RRVAMIDETRNSLYQYFLSYLQSLLLFPPKQlkppAELYPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQ 677
Cdd:pfam09731 519 RKVSLIDPEGAGLLSHALSYLLSKLMFKPKQ----GEADPAGDDVESILARAEYYLEEGDLDSAAREMNSLKGWSKKLAS 594

                         650       660
                  ....*....|....*....|....
gi 1039776046 678 DWLKEARMTLETKQIVEILTAYAS 701
Cdd:pfam09731 595 DWLKEARRRLEVQQALELLQAEAA 618
PTZ00121 PTZ00121
MAEBL; Provisional
 211-532 3.08e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 57.46  E-value: 3.08e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  211 LKTAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMktiiEDAKKREIAGATPHITAAEGRLHNMI 290
Cdd:PTZ00121  1295 AKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKA----AEAAKAEAEAAADEAEAAEEKAEAAE 1370

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  291 VDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDfRKELDSITPDITPGWKGMSISDLAGKLSTDDLNSLIAHAHRRIDQL 370
Cdd:PTZ00121  1371 KKKEEAKKKADAAKKKAEEKKKADEAKKKAEED-KKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEA 1449

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  371 NR--------ELAQQKATEKQHIELAleKHKLEEKRTFDSAVAKALEHHR----SEIQAEQDRKVEEVRDAMENEMRTQL 438
Cdd:PTZ00121  1450 KKkaeeakkaEEAKKKAEEAKKADEA--KKKAEEAKKADEAKKKAEEAKKkadeAKKAAEAKKKADEAKKAEEAKKADEA 1527

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  439 RR-QAAAHTDHLR--------DVLKVQEQELKYEFEQGLSEKLSEQE---LEFRR----------RSQEQMDSFTLDINT 496
Cdd:PTZ00121  1528 KKaEEAKKADEAKkaeekkkaDELKKAEELKKAEEKKKAEEAKKAEEdknMALRKaeeakkaeeaRIEEVMKLYEEEKKM 1607

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1039776046  497 AYARLRGIEQAvqshAVAEEEARKAHQLWLSVEALK 532
Cdd:PTZ00121  1608 KAEEAKKAEEA----KIKAEELKKAEEEKKKVEQLK 1639
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 227-532 3.06e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 54.17  E-value: 3.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 227 AQWRTVEGALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKReiagatphITAAEGRLHNMIVDLDNVVKKVQAAQSE 306
Cdd:COG1196   232 LKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE--------LEELELELEEAQAEEYELLAELARLEQD 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 307 akvvsqyHELVVQARDDFRKELDSItpditpgwkgmsisdlagklsTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIE 386
Cdd:COG1196   304 -------IARLEERRRELEERLEEL---------------------EEELAELEEELEELEEELEELEEELEEAEEELEE 355

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 387 LALEKHKLEEKRtfdSAVAKALEHHRSEIQAEQDRKVEEVRDAME-----NEMRTQLRRQAAAHTDHLRDVLKVQEQELK 461
Cdd:COG1196   356 AEAELAEAEEAL---LEAEAELAEAEEELEELAEELLEALRAAAElaaqlEELEEAEEALLERLERLEEELEELEEALAE 432

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039776046 462 YEFEQGLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARLRGIEQAVQshAVAEEEARKAHQLWLSVEALK 532
Cdd:COG1196   433 LEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALA--ELLEELAEAAARLLLLLEAEA 501
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 172-510 4.39e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 50.44  E-value: 4.39e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  172 TTALAKSLEDALN-------RTSSVTLQ--TITAQNAAVQA-VKAHSNILKTamdNSEIagEKKSAQWRTVEGALKERRK 241
Cdd:TIGR02168  624 GVLVVDDLDNALElakklrpGYRIVTLDgdLVRPGGVITGGsAKTNSSILER---RREI--EELEEKIEELEEKIAELEK 698

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  242 AVDEAADALLKAKEELEKMKTIIEDaKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQAR 321
Cdd:TIGR02168  699 ALAELRKELEELEEELEQLRKELEE-LSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEEL 777

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  322 DDFRKELDSITPDITPGWKGMSISDLAGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEK---------- 391
Cdd:TIGR02168  778 AEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIeelsediesl 857

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  392 -HKLEEKRTFDSAVAKALEHHrSEIQAEQDRKVEEVRDAMENEM---------RTQLRRQAAAHTDHLRDvLKVQEQELK 461
Cdd:TIGR02168  858 aAEIEELEELIEELESELEAL-LNERASLEEALALLRSELEELSeelreleskRSELRRELEELREKLAQ-LELRLEGLE 935

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039776046  462 YEFEQgLSEKLSEQ---ELEFrrrSQEQMDSFTLDINTAYARLRGIEQAVQS 510
Cdd:TIGR02168  936 VRIDN-LQERLSEEyslTLEE---AEALENKIEDDEEEARRRLKRLENKIKE 983
 
Name Accession Description Interval E-value
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 43-701 0e+00

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 585.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  43 AGKIAGAGLLFVGGGIGGTILYAKWDSHFRESVEKTIPYSDKLFGMVLGSAPYTVPlpkKPVQSGPLKISSVSEVMKDSK 122
Cdd:pfam09731   4 FGKFFVALVLIVGVGYGGVVLYAYKDDNFRDFFEEYIPYGEEVVLYALGEDPPLAP---KPKTFRPLQPSVVSAVTGESK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 123 LPVAQSQKTKGDTPASAG-DTLSVPAPAVQHEDTIKTECPNTNEGKSTsettALAKSLEDALNRTSSVTLQTITAQNAAV 201
Cdd:pfam09731  81 EPKEEKKQVKIPRQSGVSsEVAEEEKEATKDAAEAKAQLPKSEQEKEK----ALEEVLKEAISKAESATAVAKEAKDDAI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 202 QAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALKErrkavdeaadallkakeeleKMKTIIEDAKKREIAGATPHITA 281
Cdd:pfam09731 157 QAVKAHTDSLKEASDTAEISREKATDSALQKAEALAE--------------------KLKEVINLAKQSEEEAAPPLLDA 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 282 AEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSITPDITPGWKGMSisdlagKLSTDDLNSLIA 361
Cdd:pfam09731 217 APETPPKLPEHLDNVEEKVEKAQSLAKLVDQYKELVASERIVFQQELVSIFPDIIPVLKEDN------LLSNDDLNSLIA 290

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 362 HAHRRIDQLNRELAQQKATEKQHIELALEKHKlEEKRTFDSAVAKALEHHRS----EIQAEQDRKVEEVRDAMENEMRTQ 437
Cdd:pfam09731 291 HAHREIDQLSKKLAELKKREEKHIERALEKQK-EELDKLAEELSARLEEVRAadeaQLRLEFEREREEIRESYEEKLRTE 369

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 438 LRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSEKLSEQElefrrrsqeqmDSFTLDINTAYARLRGIEQAVQSHAVAEEE 517
Cdd:pfam09731 370 LERQAEAHEEHLKDVLVEQEIELQREFLQDIKEKVEEER-----------AGRLLKLNELLANLKGLEKATSSHSEVEDE 438

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 518 ARKAHQLWLSVEALKYSMKTSSAEMPTIPLGSAVEAIRVNCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLA 597
Cdd:pfam09731 439 NRKAQQLWLAVEALRSTLEDGSADSRPRPLVRELKALKELASDDEVVKAALASLPEEAYQRGVYTEAALRERFRRVAKEV 518

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 598 RRVAMIDETRNSLYQYFLSYLQSLLLFPPKQlkppAELYPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQ 677
Cdd:pfam09731 519 RKVSLIDPEGAGLLSHALSYLLSKLMFKPKQ----GEADPAGDDVESILARAEYYLEEGDLDSAAREMNSLKGWSKKLAS 594

                         650       660
                  ....*....|....*....|....
gi 1039776046 678 DWLKEARMTLETKQIVEILTAYAS 701
Cdd:pfam09731 595 DWLKEARRRLEVQQALELLQAEAA 618
PTZ00121 PTZ00121
MAEBL; Provisional
 211-532 3.08e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 57.46  E-value: 3.08e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  211 LKTAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEKMktiiEDAKKREIAGATPHITAAEGRLHNMI 290
Cdd:PTZ00121  1295 AKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKA----AEAAKAEAEAAADEAEAAEEKAEAAE 1370

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  291 VDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDfRKELDSITPDITPGWKGMSISDLAGKLSTDDLNSLIAHAHRRIDQL 370
Cdd:PTZ00121  1371 KKKEEAKKKADAAKKKAEEKKKADEAKKKAEED-KKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEA 1449

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  371 NR--------ELAQQKATEKQHIELAleKHKLEEKRTFDSAVAKALEHHR----SEIQAEQDRKVEEVRDAMENEMRTQL 438
Cdd:PTZ00121  1450 KKkaeeakkaEEAKKKAEEAKKADEA--KKKAEEAKKADEAKKKAEEAKKkadeAKKAAEAKKKADEAKKAEEAKKADEA 1527

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  439 RR-QAAAHTDHLR--------DVLKVQEQELKYEFEQGLSEKLSEQE---LEFRR----------RSQEQMDSFTLDINT 496
Cdd:PTZ00121  1528 KKaEEAKKADEAKkaeekkkaDELKKAEELKKAEEKKKAEEAKKAEEdknMALRKaeeakkaeeaRIEEVMKLYEEEKKM 1607

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1039776046  497 AYARLRGIEQAvqshAVAEEEARKAHQLWLSVEALK 532
Cdd:PTZ00121  1608 KAEEAKKAEEA----KIKAEELKKAEEEKKKVEQLK 1639
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 227-532 3.06e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 54.17  E-value: 3.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 227 AQWRTVEGALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKReiagatphITAAEGRLHNMIVDLDNVVKKVQAAQSE 306
Cdd:COG1196   232 LKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE--------LEELELELEEAQAEEYELLAELARLEQD 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 307 akvvsqyHELVVQARDDFRKELDSItpditpgwkgmsisdlagklsTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIE 386
Cdd:COG1196   304 -------IARLEERRRELEERLEEL---------------------EEELAELEEELEELEEELEELEEELEEAEEELEE 355

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 387 LALEKHKLEEKRtfdSAVAKALEHHRSEIQAEQDRKVEEVRDAME-----NEMRTQLRRQAAAHTDHLRDVLKVQEQELK 461
Cdd:COG1196   356 AEAELAEAEEAL---LEAEAELAEAEEELEELAEELLEALRAAAElaaqlEELEEAEEALLERLERLEEELEELEEALAE 432

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039776046 462 YEFEQGLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARLRGIEQAVQshAVAEEEARKAHQLWLSVEALK 532
Cdd:COG1196   433 LEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALA--ELLEELAEAAARLLLLLEAEA 501
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
227-455 1.67e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 51.45  E-value: 1.67e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  227 AQWRTVEGALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKR----EIAGATPHITAAEGRLHNmiVDLDNVVKKVQA 302
Cdd:COG4913    692 EQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRleaaEDLARLELRALLEERFAA--ALGDAVERELRE 769

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  303 A------QSEAKVVSQYHELV--------------------VQARDDFRKELDSITPDITPG-----------WKGMSIS 345
Cdd:COG4913    770 NleeridALRARLNRAEEELEramrafnrewpaetadldadLESLPEYLALLDRLEEDGLPEyeerfkellneNSIEFVA 849

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  346 DLAGKLSTDdlnslIAHAHRRIDQLNRELAQQKATEKQHIELALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEE 425
Cdd:COG4913    850 DLLSKLRRA-----IREIKERIDPLNDSLKRIPFGPGRYLRLEARPRPDPEVREFRQELRAVTSGASLFDEELSEARFAA 924

                          250       260       270
                   ....*....|....*....|....*....|.
gi 1039776046  426 VRDAMEnemrtQLRRQAAAHTDH-LRDVLKV 455
Cdd:COG4913    925 LKRLIE-----RLRSEEEESDRRwRARVLDV 950
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 172-510 4.39e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 50.44  E-value: 4.39e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  172 TTALAKSLEDALN-------RTSSVTLQ--TITAQNAAVQA-VKAHSNILKTamdNSEIagEKKSAQWRTVEGALKERRK 241
Cdd:TIGR02168  624 GVLVVDDLDNALElakklrpGYRIVTLDgdLVRPGGVITGGsAKTNSSILER---RREI--EELEEKIEELEEKIAELEK 698

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  242 AVDEAADALLKAKEELEKMKTIIEDaKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQAR 321
Cdd:TIGR02168  699 ALAELRKELEELEEELEQLRKELEE-LSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEEL 777

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  322 DDFRKELDSITPDITPGWKGMSISDLAGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEK---------- 391
Cdd:TIGR02168  778 AEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIeelsediesl 857

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  392 -HKLEEKRTFDSAVAKALEHHrSEIQAEQDRKVEEVRDAMENEM---------RTQLRRQAAAHTDHLRDvLKVQEQELK 461
Cdd:TIGR02168  858 aAEIEELEELIEELESELEAL-LNERASLEEALALLRSELEELSeelreleskRSELRRELEELREKLAQ-LELRLEGLE 935

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039776046  462 YEFEQgLSEKLSEQ---ELEFrrrSQEQMDSFTLDINTAYARLRGIEQAVQS 510
Cdd:TIGR02168  936 VRIDN-LQERLSEEyslTLEE---AEALENKIEDDEEEARRRLKRLENKIKE 983
ARGLU pfam15346
Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is ...
 404-523 3.07e-05

Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.


Pssm-ID: 405931 [Multi-domain]  Cd Length: 151  Bit Score: 44.66  E-value: 3.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 404 VAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAhtdhlrdvlKVQEQELKYEFEQGLSEKLSEQELEFRRRS 483
Cdd:pfam15346  24 VEEELEKRKDEIEAEVERRVEEARKIMEKQVLEELEREREA---------ELEEERRKEEEERKKREELERILEENNRKI 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1039776046 484 QEQMDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQ 523
Cdd:pfam15346  95 EEAQRKEAEERLAMLEEQRRMKEERQRREKEEEEREKREQ 134
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 354-522 1.97e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.06  E-value: 1.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  354 DDLNSLIAHAHRRIDQLNREL--AQQKATEKQ-HIELALEKH-----KLEEKRTFDSAVAKALEHHRSEIQ------AEQ 419
Cdd:TIGR02169  691 SSLQSELRRIENRLDELSQELsdASRKIGEIEkEIEQLEQEEeklkeRLEELEEDLSSLEQEIENVKSELKeleariEEL 770

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  420 DRKVEEVRDAMEN-----------EMRTQLRRQAAAHTDhLRDVLKVQEQEL-KYEFEQGLSEKLSEQELEFRRRSQEQM 487
Cdd:TIGR02169  771 EEDLHKLEEALNDlearlshsripEIQAELSKLEEEVSR-IEARLREIEQKLnRLTLEKEYLEKEIQELQEQRIDLKEQI 849

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1039776046  488 DSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 522
Cdd:TIGR02169  850 KSIEKEIENLNGKKEELEEELEELEAALRDLESRL 884
PTZ00121 PTZ00121
MAEBL; Provisional
 196-524 3.45e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.36  E-value: 3.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  196 AQNAAVQAVKAHsNILKTAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEK---MKTIIEDAKKREI 272
Cdd:PTZ00121  1449 AKKKAEEAKKAE-EAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKadeAKKAEEAKKADEA 1527

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  273 AGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSE-AKVVSQYHELVVQARDDFRKELDSITPDITPGWKGMSISDLAGKL 351
Cdd:PTZ00121  1528 KKAEEAKKADEAKKAEEKKKADELKKAEELKKAEeKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKM 1607

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  352 STDDLNSLiAHAHRRIDQLNRELAQQKATEKQHIELALEKHKLEE--KRTFDSAVAKALEHHRSEiqaEQDRKVEEVRDA 429
Cdd:PTZ00121  1608 KAEEAKKA-EEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEElkKAEEENKIKAAEEAKKAE---EDKKKAEEAKKA 1683

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  430 MENEMrtqlrrqaaahtdhlrdvlKVQEQELKYEFEQGLSEKLSEQELEFRRRSQEQMDSftldintAYARLRGIEQAVQ 509
Cdd:PTZ00121  1684 EEDEK-------------------KAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKA-------EEENKIKAEEAKK 1737

                          330
                   ....*....|....*
gi 1039776046  510 ShavAEEEARKAHQL 524
Cdd:PTZ00121  1738 E---AEEDKKKAEEA 1749
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 170-475 3.50e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 44.06  E-value: 3.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  170 SETTALAKSLEDAlNRTSSVTLQTITAQnaAVQAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADA 249
Cdd:pfam12128  664 SEKDKKNKALAER-KDSANERLNSLEAQ--LKQLDKKHQAWLEEQKEQKREARTEKQAYWQVVEGALDAQLALLKAAIAA 740

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  250 L-LKAKEELEKMKTiiedAKKREIAGATPHitaaEGRLHNMIVDLDNVVKKV-QAAQSEAKVVSQ---YHELVVQARDDF 324
Cdd:pfam12128  741 RrSGAKAELKALET----WYKRDLASLGVD----PDVIAKLKREIRTLERKIeRIAVRRQEVLRYfdwYQETWLQRRPRL 812

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  325 RKELDSITpditpgwkgMSISDLagklsTDDLNSLIAHAHRRIDQLNRELaqqKATEKQHIELALEKHKLeekRTFDSAV 404
Cdd:pfam12128  813 ATQLSNIE---------RAISEL-----QQQLARLIADTKLRRAKLEMER---KASEKQQVRLSENLRGL---RCEMSKL 872

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039776046  405 AKALEHHRSE----IQAEQDRKVEEVRDAMENEMrtqlrRQAAAHTDHLRDVLKVQEQELKYEFEQGLSEKLSEQ 475
Cdd:pfam12128  873 ATLKEDANSEqaqgSIGERLAQLEDLKLKRDYLS-----ESVKKYVEHFKNVIADHSGSGLAETWESLREEDHYQ 942
PTZ00121 PTZ00121
MAEBL; Provisional
 365-541 6.24e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 6.24e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  365 RRIDQLNR-ELAQQKATEKQHIElalEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQaa 443
Cdd:PTZ00121  1224 KKAEAVKKaEEAKKDAEEAKKAE---EERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKA-- 1298

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  444 ahtdhlRDVLKVQEQELKYEfEQGLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARlRGIEQAVQSHAVAEEEARKAHQ 523
Cdd:PTZ00121  1299 ------EEKKKADEAKKKAE-EAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAA-KAEAEAAADEAEAAEEKAEAAE 1370

                          170
                   ....*....|....*...
gi 1039776046  524 LWLSVEALKYSMKTSSAE 541
Cdd:PTZ00121  1371 KKKEEAKKKADAAKKKAE 1388
COG4223 COG4223
Uncharacterized conserved protein [Function unknown];
468-702 7.02e-04

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443367 [Multi-domain]  Cd Length: 259  Bit Score: 41.96  E-value: 7.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 468 LSEKLSEQELEFRRRSQEQMDsftLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSaemptiPL 547
Cdd:COG4223    39 LEARLAALRAALAAAREAVAA---AAAAALEARLAALEAKAAAPEAEAAAAARAAALALAAAALRAAVERGQ------PF 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 548 GSAVEAIRVNCSDNEFTQALTAAippesLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLlfppk 627
Cdd:COG4223   110 AAELAALEALAPDAPALAALAAF-----AATGVPTLAALRAEFPAAARAALAAARAPEADASWLDRLLAFARSLV----- 179

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039776046 628 QLKPPAElyPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKEARMTLETKQIVEILTAYASA 702
Cdd:COG4223   180 TVRRVGP--VEGDDPDAILARAEAALAAGDLAGALAELEALPEAAQAAAAPWIAKAEARLAADAALQALAAQALA 252
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
361-504 8.59e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.98  E-value: 8.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  361 AHAHRRIDQLNRELAQQKATEKQHIELALEKHKLEEkrtfDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMR----- 435
Cdd:COG4913    647 REALQRLAEYSWDEIDVASAEREIAELEAELERLDA----SSDDLAALEEQLEELEAELEELEEELDELKGEIGRlekel 722

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  436 TQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSE-KLSEQELEFRRRSQEQMDSFTLDINTAYARLRGI 504
Cdd:COG4913    723 EQAEEELDELQDRLEAAEDLARLELRALLEERFAAaLGDAVERELRENLEERIDALRARLNRAEEELERA 792
PTZ00121 PTZ00121
MAEBL; Provisional
 196-524 1.00e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.82  E-value: 1.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  196 AQNAAVQAVKAHSniLKTAMDNSEIAGEKKSAQWRTVEGALK--ERRKAVDEAADALLKAKEELEKMKTIIEDAKKREIA 273
Cdd:PTZ00121  1270 AAIKAEEARKADE--LKKAEEKKKADEAKKAEEKKKADEAKKkaEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEA 1347

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  274 GATPHITAAegrlhnmivdldnvvKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSitpditpgwkgmsisdlagKLST 353
Cdd:PTZ00121  1348 AKAEAEAAA---------------DEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEE-------------------KKKA 1393

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  354 DDLNSLIAHAHRRIDQLNRELAQQKATEKQhielaleKHKLEEKRTFDSAVAKAlehhrseiqaEQDRKVEEVRDAMENE 433
Cdd:PTZ00121  1394 DEAKKKAEEDKKKADELKKAAAAKKKADEA-------KKKAEEKKKADEAKKKA----------EEAKKADEAKKKAEEA 1456

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  434 MRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSEKLSEQELEFRRRSQEQMDSftldintayARLRGIEQAVQS-HA 512
Cdd:PTZ00121  1457 KKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKA---------DEAKKAEEAKKAdEA 1527

                          330
                   ....*....|..
gi 1039776046  513 VAEEEARKAHQL 524
Cdd:PTZ00121  1528 KKAEEAKKADEA 1539
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 373-545 1.12e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.42  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 373 ELAQQKATEKQHIELALEKHKLEEKRtfdsavaKALEHHRSeiQAEQDRKVEEVRDAMENEMRTqlRRQAAAHTDHLRDV 452
Cdd:pfam17380 449 ERVRLEEQERQQQVERLRQQEEERKR-------KKLELEKE--KRDRKRAEEQRRKILEKELEE--RKQAMIEEERKRKL 517

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 453 LKVQEQELK---YEFEQ---GLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARLRgiEQAVQSHAVAEEEARKAHQLWL 526
Cdd:pfam17380 518 LEKEMEERQkaiYEEERrreAEEERRKQQEMEERRRIQEQMRKATEERSRLEAMER--EREMMRQIVESEKARAEYEATT 595

                         170       180
                  ....*....|....*....|.
gi 1039776046 527 SVEALK--YSMKTSSAEMPTI 545
Cdd:pfam17380 596 PITTIKpiYRPRISEYQPPDV 616
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 372-521 2.08e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.46  E-value: 2.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 372 RELaQQKATEKQHIELALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRdamenEMRTQLRRQAAAHTDHLRD 451
Cdd:COG1196   216 REL-KEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELE-----ELRLELEELELELEEAQAE 289

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 452 VLKVQEQELKYEFEQGLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKA 521
Cdd:COG1196   290 EYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAE 359
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 246-483 2.51e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.90  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 246 AADALLKAKEELEKMKTIIEdAKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFR 325
Cdd:COG4942    18 QADAAAEAEAELEQLQQEIA-ELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELR 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 326 KELDSITPDITP----GWKGMSISDLAGKLSTDDLNSLIAHAhRRIDQLNRELAQQ-KATEKQHIELALEKHKLEEKRTF 400
Cdd:COG4942    97 AELEAQKEELAEllraLYRLGRQPPLALLLSPEDFLDAVRRL-QYLKYLAPARREQaEELRADLAELAALRAELEAERAE 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 401 DSAVAKALEHHRSEIQAEQDRKveevrdameNEMRTQLRRQAAAHTDHLRDvLKVQEQELkyefeQGLSEKLSEQELEFR 480
Cdd:COG4942   176 LEALLAELEEERAALEALKAER---------QKLLARLEKELAELAAELAE-LQQEAEEL-----EALIARLEAEAAAAA 240


                  ...
gi 1039776046 481 RRS 483
Cdd:COG4942   241 ERT 243
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 368-486 2.84e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 41.11  E-value: 2.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  368 DQLNRELAQQKATEKQHIELALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHtd 447
Cdd:TIGR00618  256 LKKQQLLKQLRARIEELRAQEAVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAH-- 333

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1039776046  448 hlrdvlkvQEQELKYEFEQGLSEKLSEQELEFRRRSQEQ 486
Cdd:TIGR00618  334 --------VKQQSSIEEQRRLLQTLHSQEIHIRDAHEVA 364
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 170-478 5.10e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.31  E-value: 5.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 170 SETTALAKSLEDALNRTSSVTLQTITAQNAAVQAVKAHsNILKTAMDNSEIAGE-----KKSAQWRTVEGAL-------K 237
Cdd:COG1196   456 EEEEALLELLAELLEEAALLEAALAELLEELAEAAARL-LLLLEAEADYEGFLEgvkaaLLLAGLRGLAGAVavligveA 534

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 238 ERRKAVDEAADALLKAK--EELEKMKTIIEDAKKREIAGAT--PHITAAEGRLHNMIVDLDNVVKKVQAAQSEAkvvsQY 313
Cdd:COG1196   535 AYEAALEAALAAALQNIvvEDDEVAAAAIEYLKAAKAGRATflPLDKIRARAALAAALARGAIGAAVDLVASDL----RE 610

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 314 HELVVQARDDFRKELDSITPDITPGWKGMSISDLAGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEKHK 393
Cdd:COG1196   611 ADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAE 690

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046 394 LEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEvrdamENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSEKLS 473
Cdd:COG1196   691 EELELEEALLAEEEEERELAEAEEERLEEELE-----EEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEEL 765


                  ....*
gi 1039776046 474 EQELE 478
Cdd:COG1196   766 ERELE 770
PTZ00121 PTZ00121
MAEBL; Provisional
 212-490 5.29e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.51  E-value: 5.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  212 KTAMDNSEIAGEKKSA-QWRTVEGALK--ERRKAVDEAADALLKAKEELEKMKTI--IEDAKKREIAGATPHITA----- 281
Cdd:PTZ00121  1509 KKKADEAKKAEEAKKAdEAKKAEEAKKadEAKKAEEKKKADELKKAEELKKAEEKkkAEEAKKAEEDKNMALRKAeeakk 1588

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  282 AEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSITPDITPGWKG---MSISDLAGKLSTDDLNS 358
Cdd:PTZ00121  1589 AEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKaeeLKKAEEENKIKAAEEAK 1668

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  359 LIAHAHRRIDQLNRELAQQKATEKQHIELALEKHKLEEKRTFDSAVAKALEHHRSEiQAEQDRKVEEVRDAMENEMRT-- 436
Cdd:PTZ00121  1669 KAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKA-EEENKIKAEEAKKEAEEDKKKae 1747

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776046  437 QLRRQAAAHTD--HLRDVLKVQEQELKYE----FEQGLSEKLSEQELEFRRRSQEQMDSF 490
Cdd:PTZ00121  1748 EAKKDEEEKKKiaHLKKEEEKKAEEIRKEkeavIEEELDEEDEKRRMEVDKKIKDIFDNF 1807
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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