NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1039775738|ref|XP_017177223|]
View 

nuclear pore complex protein Nup205 isoform X2 [Mus musculus]

Protein Classification

nuclear pore complex Nup192/Nup205 family protein( domain architecture ID 10571003)

nuclear pore complex Nup192/Nup205 family protein; similar to Homo sapiens Nup205 and Saccharomyces cerevisiae Nup192, which are components (nucleoporins, NUPs) of the nuclear pore complex (NPC) that can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Nup192 pfam11894
Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic ...
 125-1644 0e+00

Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic nucleoporins of several different sizes. All of them are long and form the scaffold of the nuclear pore complex. Nup192 in particular modulates the permeability of the central channel of the NPC central or nuclear pore complex.


:

Pssm-ID: 463387  Cd Length: 1484  Bit Score: 1085.36  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  125 ELVSMTTRFTDELME-QGLTYKVLTLLSQIDVNNEfekLQRERGLGSEKHRKevsDLIKECRQSLAESLFAWACQSPLPK 203
Cdd:pfam11894    3 SATTLVTNILDSFKEiHGLLQRLLDLVNKADILGE---IQDNRFLGTIKFRR---DSLFKEHELLAQILFGLVAQRGLPK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  204 DDTLLLIGHLERVtveanGSLDAVNLCLLMALLYCFDtsfidqSTEERddmihhLPLLTERQYVSTIHSRLQDSqpWKLP 283
Cdd:pfam11894   77 DDFLKLIDHAKKA-----DKYDFLTLHYLPALLAAFG------SLEDL------SVLQDVRELHSKITKSLDSE--WPLY 137

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  284 --GLQATVRLAWALALRG-ISQLPD-VTALAEFTEADEAIAELAIADNVFLFLseAVVLAEN------------------ 341
Cdd:pfam11894  138 tdGLKAAIIFVFLAEFIGwCKQEPEeRAKQFDFKEDIEKPMDEALEDGAFEFL--LSIAADTsnkdwedplrydfrsllq 215

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  342 --------------FYQEEFYIRRIHSLITDFLAFMPMKVKQLKNRADEDARMIHMSIQMGneppislRRDLEHLMLLIG 407
Cdd:pfam11894  216 rhiprltpeklllsDYFEEFLLRQLHTFITDFISNMADVLTKLRDREEDSLLSQESLLQEG-------RADLERFLLIIA 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  408 ELYKKNPfhlELALEYWcpseplqtptvmgsylgvahqrpPQRQVVLSKFVRQMGDLLPPTIYIPYLKMLQGLANGPQCA 487
Cdd:pfam11894  289 YLYEGRP---DLALEFW-----------------------SDRESNLYGFIEWASSRLPSPLISAFCLMLSSLSSGEENA 342

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  488 HYCFSLLKVNGSSHVENiqgaGGSPVSWEHFFHSLLLYHEHLRKDLPSA----DSVQYRHLPSRGITQKEQDGLIAFLQL 563
Cdd:pfam11894  343 RAAFNFLKDNNNSGKKR----RSSSVSWDHIFDSLNYYIDKLRQKPENFesdgDRQQRQEAIPIELEPESIIFLSSYLRL 418

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  564 TSTIITWSENARLALCEHPQWTPVVVILGLLQCSIPPVLKAELLKTLAAFG-KSPEIAASLWQSLE-----YTQILQTVR 637
Cdd:pfam11894  419 ISSVAKNSEEARLALLEHPSWRFLDVLFGLLSCKVPTPLKAAILNTLSALVkKSEEEAYQIWRSLDrwifgGSQLLPTVP 498

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  638 VPSQRQAIGIEVELNEIESRCEEYPLTRAFCQLISTLVES-----------SFPSNLGAGLRPPGFDPYLQFLRDSVFLR 706
Cdd:pfam11894  499 RTSSYKPRGSYSELEAFESRLEGYPEVRAFLQLLKALLSPpedssslfgklPFPENLGAGYRKPGIWPYLDFVLDEVFLK 578

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  707 fRTRAYRRAAEKWEVAEVVLEVFYKLLRDYEPQLEDFVDQFVE-----LQGEEIIAY-KPPGFSLMYHLLNESPMLELAL 780
Cdd:pfam11894  579 -STRDYKDPAEKWELQLSCLEFIETCLRSFDPSLILFSNPSGInldslVSTSDFATYvKLHPFHAVLNYLFNEKVLKALF 657

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  781 SLLEEGVKQLDTYApfpGKKHLEKAVQHCLALLNLTLQKENLFMDLLR----ESQLALIVSPL---------EQLLQGIN 847
Cdd:pfam11894  658 SIIDEGVDELDNYL---GKSPLELLVLLALEIIDKVLDLQETYLDELLpilkKSQNIYRPKNVgnhglssfyDALLFNLS 734

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  848 prtkkadNVVNIARYLYHGnnNPELAFESAKILCCISCNSNI----------QVKMVGDFTHDQSvSQKLMAGFVECLDY 917
Cdd:pfam11894  735 -------LVLNLGLYVGYG--HPELALASLKILEKISSSPKFsassagrllhRNKLLTIFESVDE-SERIKRGFIEQLEA 804

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  918 EDTEEfvrveegselEKKLAAIRHETRIHILNLLITSLERNP--PNLALYLLGFELKKPISTTNLQDPgVLGCPRTCLHA 995
Cdd:pfam11894  805 PIDEE----------EQGAESIGLQIKEAILDFLNSNLSASPkrPTIAHFLLGFDVRNDLSLGPDQST-FIASPRSLLHS 873

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  996 ILNILEKGTEGRDGPVAVREYP-QLADLCYQVIYQLCACSDTSGPTMRYLRtSQDFLFSQLQHLPFSNKEHE-------- 1066
Cdd:pfam11894  874 LLLLLLSSLDLISEGDYIDYAPaRLAELILEILYKLCRNPLTSSITLRYLR-ENCFLFRHLLSLPPKIDPNTlwngqsfd 952

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738 1067 -------------ISMLSQMSWLMKTASIELRVTSLNRQRSHTQRLLHLLLDDMPVKpysdgeggmedenrsvsgflhfD 1133
Cdd:pfam11894  953 gvffisspsagalLSFLNQRSLLLQYLSLELHSTSQSGSPSKKKRYVDLLLGNNILD----------------------G 1010

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738 1134 TATKVRRKILSILDSIDFS-QEIPEPLQLDFFDRAQIEQVIANCEHKNLQ-GQTVCNVKLLHRVLVAEV---NALQGMAA 1208
Cdd:pfam11894 1011 GEPIGSPTIFDFLDFLNFEfINFEPQPQLEFFDIKNLSLDLDKCELDDADsGNKLYDISKLHELLRLELkqlLLVQGESK 1090

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738 1209 IGQRPLLMEEISTILQYVVGRNKLLQCLHAKRHALESWRQLVEIILTACpqeLIQAEDRQLIIRDLLQDVHDKV-----L 1283
Cdd:pfam11894 1091 AGQEKEIMAEINKILEFATKYNRQKQLRAAQLSFLHSWVQLVQVLVSDG---DLSSTVRSNFILEVLQAILPKIndyveL 1167

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738 1284 DDEAAQELMPVVAGAVFTLTAHLSQAVRTEQRQplvsgpgeaqyafmldssltsspaaesrpvgFASIGDSSLHIILKKL 1363
Cdd:pfam11894 1168 DIAFAEELASLASVLLFDLYAKLRQCINLDEEQ-------------------------------KGNLSSDRLHQLFKTC 1216

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738 1364 LDFILKTgGGFQRVRTHLYGSLLYYLQIAQRPDepdtleaakktmwerltapeDVFSKLQRENMAIIESYGAALMEVVCR 1443
Cdd:pfam11894 1217 IDGILSS-GSTQKLRSDLYVILNNYLQIVFKNR--------------------SSEESLRKETLQIIKSYGEKLIEVICN 1275

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738 1444 DACDGHEIGRMLALALLDRIVSVD--KQHQWLLYLSNSGYLKVLVDSLVDDDRTLQSLLTPQPPLLKALY--TYESKMAF 1519
Cdd:pfam11894 1276 DAIGGEGTCRITALLLLDSLVHLDsnKSNFILETLSKNNYLLLLVRSLKRTDEELRECLAPDPESLDPLYetAFESKLAL 1355

                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738 1520 LTRVAKEQQGSAELLRSGVIVRLAQCQVYDMRPEMdshGMFgmRDPPVFIPTPVDRYRQILLPALQLCQVILTSSMSQHL 1599
Cdd:pfam11894 1356 LIRIAQTRLGAQQLLQNGLFSVLESCKFLAIDPDL---GLS--LDNPLSLPDALERYFELLVPVLQLITAILLSLGSSNK 1430

                         1610      1620      1630      1640      1650
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039775738 1600 QAAGQVLQFLVSHSDTIQAILR---------CQDVSTGSLQELALLTGIISKAA 1644
Cdd:pfam11894 1431 SAIEQVRKFLKHHRDLVVGVLKrdalpesgiGYAELEEGLQELAKLFVLLATLT 1484
 
Name Accession Description Interval E-value
Nup192 pfam11894
Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic ...
 125-1644 0e+00

Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic nucleoporins of several different sizes. All of them are long and form the scaffold of the nuclear pore complex. Nup192 in particular modulates the permeability of the central channel of the NPC central or nuclear pore complex.


Pssm-ID: 463387  Cd Length: 1484  Bit Score: 1085.36  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  125 ELVSMTTRFTDELME-QGLTYKVLTLLSQIDVNNEfekLQRERGLGSEKHRKevsDLIKECRQSLAESLFAWACQSPLPK 203
Cdd:pfam11894    3 SATTLVTNILDSFKEiHGLLQRLLDLVNKADILGE---IQDNRFLGTIKFRR---DSLFKEHELLAQILFGLVAQRGLPK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  204 DDTLLLIGHLERVtveanGSLDAVNLCLLMALLYCFDtsfidqSTEERddmihhLPLLTERQYVSTIHSRLQDSqpWKLP 283
Cdd:pfam11894   77 DDFLKLIDHAKKA-----DKYDFLTLHYLPALLAAFG------SLEDL------SVLQDVRELHSKITKSLDSE--WPLY 137

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  284 --GLQATVRLAWALALRG-ISQLPD-VTALAEFTEADEAIAELAIADNVFLFLseAVVLAEN------------------ 341
Cdd:pfam11894  138 tdGLKAAIIFVFLAEFIGwCKQEPEeRAKQFDFKEDIEKPMDEALEDGAFEFL--LSIAADTsnkdwedplrydfrsllq 215

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  342 --------------FYQEEFYIRRIHSLITDFLAFMPMKVKQLKNRADEDARMIHMSIQMGneppislRRDLEHLMLLIG 407
Cdd:pfam11894  216 rhiprltpeklllsDYFEEFLLRQLHTFITDFISNMADVLTKLRDREEDSLLSQESLLQEG-------RADLERFLLIIA 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  408 ELYKKNPfhlELALEYWcpseplqtptvmgsylgvahqrpPQRQVVLSKFVRQMGDLLPPTIYIPYLKMLQGLANGPQCA 487
Cdd:pfam11894  289 YLYEGRP---DLALEFW-----------------------SDRESNLYGFIEWASSRLPSPLISAFCLMLSSLSSGEENA 342

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  488 HYCFSLLKVNGSSHVENiqgaGGSPVSWEHFFHSLLLYHEHLRKDLPSA----DSVQYRHLPSRGITQKEQDGLIAFLQL 563
Cdd:pfam11894  343 RAAFNFLKDNNNSGKKR----RSSSVSWDHIFDSLNYYIDKLRQKPENFesdgDRQQRQEAIPIELEPESIIFLSSYLRL 418

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  564 TSTIITWSENARLALCEHPQWTPVVVILGLLQCSIPPVLKAELLKTLAAFG-KSPEIAASLWQSLE-----YTQILQTVR 637
Cdd:pfam11894  419 ISSVAKNSEEARLALLEHPSWRFLDVLFGLLSCKVPTPLKAAILNTLSALVkKSEEEAYQIWRSLDrwifgGSQLLPTVP 498

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  638 VPSQRQAIGIEVELNEIESRCEEYPLTRAFCQLISTLVES-----------SFPSNLGAGLRPPGFDPYLQFLRDSVFLR 706
Cdd:pfam11894  499 RTSSYKPRGSYSELEAFESRLEGYPEVRAFLQLLKALLSPpedssslfgklPFPENLGAGYRKPGIWPYLDFVLDEVFLK 578

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  707 fRTRAYRRAAEKWEVAEVVLEVFYKLLRDYEPQLEDFVDQFVE-----LQGEEIIAY-KPPGFSLMYHLLNESPMLELAL 780
Cdd:pfam11894  579 -STRDYKDPAEKWELQLSCLEFIETCLRSFDPSLILFSNPSGInldslVSTSDFATYvKLHPFHAVLNYLFNEKVLKALF 657

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  781 SLLEEGVKQLDTYApfpGKKHLEKAVQHCLALLNLTLQKENLFMDLLR----ESQLALIVSPL---------EQLLQGIN 847
Cdd:pfam11894  658 SIIDEGVDELDNYL---GKSPLELLVLLALEIIDKVLDLQETYLDELLpilkKSQNIYRPKNVgnhglssfyDALLFNLS 734

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  848 prtkkadNVVNIARYLYHGnnNPELAFESAKILCCISCNSNI----------QVKMVGDFTHDQSvSQKLMAGFVECLDY 917
Cdd:pfam11894  735 -------LVLNLGLYVGYG--HPELALASLKILEKISSSPKFsassagrllhRNKLLTIFESVDE-SERIKRGFIEQLEA 804

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  918 EDTEEfvrveegselEKKLAAIRHETRIHILNLLITSLERNP--PNLALYLLGFELKKPISTTNLQDPgVLGCPRTCLHA 995
Cdd:pfam11894  805 PIDEE----------EQGAESIGLQIKEAILDFLNSNLSASPkrPTIAHFLLGFDVRNDLSLGPDQST-FIASPRSLLHS 873

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  996 ILNILEKGTEGRDGPVAVREYP-QLADLCYQVIYQLCACSDTSGPTMRYLRtSQDFLFSQLQHLPFSNKEHE-------- 1066
Cdd:pfam11894  874 LLLLLLSSLDLISEGDYIDYAPaRLAELILEILYKLCRNPLTSSITLRYLR-ENCFLFRHLLSLPPKIDPNTlwngqsfd 952

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738 1067 -------------ISMLSQMSWLMKTASIELRVTSLNRQRSHTQRLLHLLLDDMPVKpysdgeggmedenrsvsgflhfD 1133
Cdd:pfam11894  953 gvffisspsagalLSFLNQRSLLLQYLSLELHSTSQSGSPSKKKRYVDLLLGNNILD----------------------G 1010

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738 1134 TATKVRRKILSILDSIDFS-QEIPEPLQLDFFDRAQIEQVIANCEHKNLQ-GQTVCNVKLLHRVLVAEV---NALQGMAA 1208
Cdd:pfam11894 1011 GEPIGSPTIFDFLDFLNFEfINFEPQPQLEFFDIKNLSLDLDKCELDDADsGNKLYDISKLHELLRLELkqlLLVQGESK 1090

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738 1209 IGQRPLLMEEISTILQYVVGRNKLLQCLHAKRHALESWRQLVEIILTACpqeLIQAEDRQLIIRDLLQDVHDKV-----L 1283
Cdd:pfam11894 1091 AGQEKEIMAEINKILEFATKYNRQKQLRAAQLSFLHSWVQLVQVLVSDG---DLSSTVRSNFILEVLQAILPKIndyveL 1167

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738 1284 DDEAAQELMPVVAGAVFTLTAHLSQAVRTEQRQplvsgpgeaqyafmldssltsspaaesrpvgFASIGDSSLHIILKKL 1363
Cdd:pfam11894 1168 DIAFAEELASLASVLLFDLYAKLRQCINLDEEQ-------------------------------KGNLSSDRLHQLFKTC 1216

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738 1364 LDFILKTgGGFQRVRTHLYGSLLYYLQIAQRPDepdtleaakktmwerltapeDVFSKLQRENMAIIESYGAALMEVVCR 1443
Cdd:pfam11894 1217 IDGILSS-GSTQKLRSDLYVILNNYLQIVFKNR--------------------SSEESLRKETLQIIKSYGEKLIEVICN 1275

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738 1444 DACDGHEIGRMLALALLDRIVSVD--KQHQWLLYLSNSGYLKVLVDSLVDDDRTLQSLLTPQPPLLKALY--TYESKMAF 1519
Cdd:pfam11894 1276 DAIGGEGTCRITALLLLDSLVHLDsnKSNFILETLSKNNYLLLLVRSLKRTDEELRECLAPDPESLDPLYetAFESKLAL 1355

                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738 1520 LTRVAKEQQGSAELLRSGVIVRLAQCQVYDMRPEMdshGMFgmRDPPVFIPTPVDRYRQILLPALQLCQVILTSSMSQHL 1599
Cdd:pfam11894 1356 LIRIAQTRLGAQQLLQNGLFSVLESCKFLAIDPDL---GLS--LDNPLSLPDALERYFELLVPVLQLITAILLSLGSSNK 1430

                         1610      1620      1630      1640      1650
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039775738 1600 QAAGQVLQFLVSHSDTIQAILR---------CQDVSTGSLQELALLTGIISKAA 1644
Cdd:pfam11894 1431 SAIEQVRKFLKHHRDLVVGVLKrdalpesgiGYAELEEGLQELAKLFVLLATLT 1484
 
Name Accession Description Interval E-value
Nup192 pfam11894
Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic ...
 125-1644 0e+00

Nuclear pore complex scaffold, nucleoporins 186/192/205; This is a family of eukaryotic nucleoporins of several different sizes. All of them are long and form the scaffold of the nuclear pore complex. Nup192 in particular modulates the permeability of the central channel of the NPC central or nuclear pore complex.


Pssm-ID: 463387  Cd Length: 1484  Bit Score: 1085.36  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  125 ELVSMTTRFTDELME-QGLTYKVLTLLSQIDVNNEfekLQRERGLGSEKHRKevsDLIKECRQSLAESLFAWACQSPLPK 203
Cdd:pfam11894    3 SATTLVTNILDSFKEiHGLLQRLLDLVNKADILGE---IQDNRFLGTIKFRR---DSLFKEHELLAQILFGLVAQRGLPK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  204 DDTLLLIGHLERVtveanGSLDAVNLCLLMALLYCFDtsfidqSTEERddmihhLPLLTERQYVSTIHSRLQDSqpWKLP 283
Cdd:pfam11894   77 DDFLKLIDHAKKA-----DKYDFLTLHYLPALLAAFG------SLEDL------SVLQDVRELHSKITKSLDSE--WPLY 137

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  284 --GLQATVRLAWALALRG-ISQLPD-VTALAEFTEADEAIAELAIADNVFLFLseAVVLAEN------------------ 341
Cdd:pfam11894  138 tdGLKAAIIFVFLAEFIGwCKQEPEeRAKQFDFKEDIEKPMDEALEDGAFEFL--LSIAADTsnkdwedplrydfrsllq 215

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  342 --------------FYQEEFYIRRIHSLITDFLAFMPMKVKQLKNRADEDARMIHMSIQMGneppislRRDLEHLMLLIG 407
Cdd:pfam11894  216 rhiprltpeklllsDYFEEFLLRQLHTFITDFISNMADVLTKLRDREEDSLLSQESLLQEG-------RADLERFLLIIA 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  408 ELYKKNPfhlELALEYWcpseplqtptvmgsylgvahqrpPQRQVVLSKFVRQMGDLLPPTIYIPYLKMLQGLANGPQCA 487
Cdd:pfam11894  289 YLYEGRP---DLALEFW-----------------------SDRESNLYGFIEWASSRLPSPLISAFCLMLSSLSSGEENA 342

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  488 HYCFSLLKVNGSSHVENiqgaGGSPVSWEHFFHSLLLYHEHLRKDLPSA----DSVQYRHLPSRGITQKEQDGLIAFLQL 563
Cdd:pfam11894  343 RAAFNFLKDNNNSGKKR----RSSSVSWDHIFDSLNYYIDKLRQKPENFesdgDRQQRQEAIPIELEPESIIFLSSYLRL 418

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  564 TSTIITWSENARLALCEHPQWTPVVVILGLLQCSIPPVLKAELLKTLAAFG-KSPEIAASLWQSLE-----YTQILQTVR 637
Cdd:pfam11894  419 ISSVAKNSEEARLALLEHPSWRFLDVLFGLLSCKVPTPLKAAILNTLSALVkKSEEEAYQIWRSLDrwifgGSQLLPTVP 498

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  638 VPSQRQAIGIEVELNEIESRCEEYPLTRAFCQLISTLVES-----------SFPSNLGAGLRPPGFDPYLQFLRDSVFLR 706
Cdd:pfam11894  499 RTSSYKPRGSYSELEAFESRLEGYPEVRAFLQLLKALLSPpedssslfgklPFPENLGAGYRKPGIWPYLDFVLDEVFLK 578

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  707 fRTRAYRRAAEKWEVAEVVLEVFYKLLRDYEPQLEDFVDQFVE-----LQGEEIIAY-KPPGFSLMYHLLNESPMLELAL 780
Cdd:pfam11894  579 -STRDYKDPAEKWELQLSCLEFIETCLRSFDPSLILFSNPSGInldslVSTSDFATYvKLHPFHAVLNYLFNEKVLKALF 657

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  781 SLLEEGVKQLDTYApfpGKKHLEKAVQHCLALLNLTLQKENLFMDLLR----ESQLALIVSPL---------EQLLQGIN 847
Cdd:pfam11894  658 SIIDEGVDELDNYL---GKSPLELLVLLALEIIDKVLDLQETYLDELLpilkKSQNIYRPKNVgnhglssfyDALLFNLS 734

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  848 prtkkadNVVNIARYLYHGnnNPELAFESAKILCCISCNSNI----------QVKMVGDFTHDQSvSQKLMAGFVECLDY 917
Cdd:pfam11894  735 -------LVLNLGLYVGYG--HPELALASLKILEKISSSPKFsassagrllhRNKLLTIFESVDE-SERIKRGFIEQLEA 804

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  918 EDTEEfvrveegselEKKLAAIRHETRIHILNLLITSLERNP--PNLALYLLGFELKKPISTTNLQDPgVLGCPRTCLHA 995
Cdd:pfam11894  805 PIDEE----------EQGAESIGLQIKEAILDFLNSNLSASPkrPTIAHFLLGFDVRNDLSLGPDQST-FIASPRSLLHS 873

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738  996 ILNILEKGTEGRDGPVAVREYP-QLADLCYQVIYQLCACSDTSGPTMRYLRtSQDFLFSQLQHLPFSNKEHE-------- 1066
Cdd:pfam11894  874 LLLLLLSSLDLISEGDYIDYAPaRLAELILEILYKLCRNPLTSSITLRYLR-ENCFLFRHLLSLPPKIDPNTlwngqsfd 952

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738 1067 -------------ISMLSQMSWLMKTASIELRVTSLNRQRSHTQRLLHLLLDDMPVKpysdgeggmedenrsvsgflhfD 1133
Cdd:pfam11894  953 gvffisspsagalLSFLNQRSLLLQYLSLELHSTSQSGSPSKKKRYVDLLLGNNILD----------------------G 1010

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738 1134 TATKVRRKILSILDSIDFS-QEIPEPLQLDFFDRAQIEQVIANCEHKNLQ-GQTVCNVKLLHRVLVAEV---NALQGMAA 1208
Cdd:pfam11894 1011 GEPIGSPTIFDFLDFLNFEfINFEPQPQLEFFDIKNLSLDLDKCELDDADsGNKLYDISKLHELLRLELkqlLLVQGESK 1090

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738 1209 IGQRPLLMEEISTILQYVVGRNKLLQCLHAKRHALESWRQLVEIILTACpqeLIQAEDRQLIIRDLLQDVHDKV-----L 1283
Cdd:pfam11894 1091 AGQEKEIMAEINKILEFATKYNRQKQLRAAQLSFLHSWVQLVQVLVSDG---DLSSTVRSNFILEVLQAILPKIndyveL 1167

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738 1284 DDEAAQELMPVVAGAVFTLTAHLSQAVRTEQRQplvsgpgeaqyafmldssltsspaaesrpvgFASIGDSSLHIILKKL 1363
Cdd:pfam11894 1168 DIAFAEELASLASVLLFDLYAKLRQCINLDEEQ-------------------------------KGNLSSDRLHQLFKTC 1216

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738 1364 LDFILKTgGGFQRVRTHLYGSLLYYLQIAQRPDepdtleaakktmwerltapeDVFSKLQRENMAIIESYGAALMEVVCR 1443
Cdd:pfam11894 1217 IDGILSS-GSTQKLRSDLYVILNNYLQIVFKNR--------------------SSEESLRKETLQIIKSYGEKLIEVICN 1275

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738 1444 DACDGHEIGRMLALALLDRIVSVD--KQHQWLLYLSNSGYLKVLVDSLVDDDRTLQSLLTPQPPLLKALY--TYESKMAF 1519
Cdd:pfam11894 1276 DAIGGEGTCRITALLLLDSLVHLDsnKSNFILETLSKNNYLLLLVRSLKRTDEELRECLAPDPESLDPLYetAFESKLAL 1355

                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039775738 1520 LTRVAKEQQGSAELLRSGVIVRLAQCQVYDMRPEMdshGMFgmRDPPVFIPTPVDRYRQILLPALQLCQVILTSSMSQHL 1599
Cdd:pfam11894 1356 LIRIAQTRLGAQQLLQNGLFSVLESCKFLAIDPDL---GLS--LDNPLSLPDALERYFELLVPVLQLITAILLSLGSSNK 1430

                         1610      1620      1630      1640      1650
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039775738 1600 QAAGQVLQFLVSHSDTIQAILR---------CQDVSTGSLQELALLTGIISKAA 1644
Cdd:pfam11894 1431 SAIEQVRKFLKHHRDLVVGVLKrdalpesgiGYAELEEGLQELAKLFVLLATLT 1484
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH