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Conserved domains on  [gi|1039771867|ref|XP_017176434|]
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uncharacterized protein LOC381693 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 450-758 9.44e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 146.33  E-value: 9.44e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  450 NRTVFRVH-KGVKAFSFCRRKNLLVTGGLDRIIRVWNpYLPGKPTGVLRGHRAPVMYVHVAFEENKVFSMSADNTVKVWD 528
Cdd:cd00200      1 LRRTLKGHtGGVTCVAFSPDGKLLATGSGDGTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  529 LETHGCCCTIsskaSGIKGELTACLYLPGPRALCVAT--GTLAFLHLKVGSvpESHLVRSHQEPVVCCRYNPAFRHVVSC 606
Cdd:cd00200     80 LETGECVRTL----TGHTSYVSSVAFSPDGRILSSSSrdKTIKVWDVETGK--CLTTLRGHTDWVNSVAFSPDGTFVASS 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  607 CEASVVKVWDFETGRQVSEFIGtHgNAGITCLTFDSSGRRLVTGGRDGCLKIWSYNNGHCLHTLQHDENQseVCDCTYME 686
Cdd:cd00200    154 SQDGTIKLWDLRTGKCVATLTG-H-TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG--VNSVAFSP 229

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039771867  687 VNRNrcVIAVGWDRRINVYfdiprDFHHFRKPQphwqdDLnHGHKEDILCVAQCP-PFLLATSSYDGEIIVWN 758
Cdd:cd00200    230 DGYL--LASGSEDGTIRVW-----DLRTGECVQ-----TL-SGHTNSVTSLAWSPdGKRLASGSADGTIRIWD 289
EF-hand_7 pfam13499
EF-hand domain pair;
113-177 1.31e-04

EF-hand domain pair;


:

Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 41.08  E-value: 1.31e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039771867  113 RLNALFQEHEKRGSQLLDMETFKCMMKQSLRSHSKSIGQIEQLFMKIDYEAVGRIQWDSFCTYLQ 177
Cdd:pfam13499    3 KLKEAFKLLDSDGDGYLDVEELKKLLRKLEEGEPLSDEEVEELFKEFDLDKDGRISFEEFLELYS 67
WD40 pfam00400
WD domain, G-beta repeat;
882-917 1.61e-03

WD domain, G-beta repeat;


:

Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.61e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1039771867  882 VTSWRAHVSMVTSLELIEGGSIVLSSSLDCTVRLWS 917
Cdd:pfam00400    4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 450-758 9.44e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 146.33  E-value: 9.44e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  450 NRTVFRVH-KGVKAFSFCRRKNLLVTGGLDRIIRVWNpYLPGKPTGVLRGHRAPVMYVHVAFEENKVFSMSADNTVKVWD 528
Cdd:cd00200      1 LRRTLKGHtGGVTCVAFSPDGKLLATGSGDGTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  529 LETHGCCCTIsskaSGIKGELTACLYLPGPRALCVAT--GTLAFLHLKVGSvpESHLVRSHQEPVVCCRYNPAFRHVVSC 606
Cdd:cd00200     80 LETGECVRTL----TGHTSYVSSVAFSPDGRILSSSSrdKTIKVWDVETGK--CLTTLRGHTDWVNSVAFSPDGTFVASS 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  607 CEASVVKVWDFETGRQVSEFIGtHgNAGITCLTFDSSGRRLVTGGRDGCLKIWSYNNGHCLHTLQHDENQseVCDCTYME 686
Cdd:cd00200    154 SQDGTIKLWDLRTGKCVATLTG-H-TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG--VNSVAFSP 229

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039771867  687 VNRNrcVIAVGWDRRINVYfdiprDFHHFRKPQphwqdDLnHGHKEDILCVAQCP-PFLLATSSYDGEIIVWN 758
Cdd:cd00200    230 DGYL--LASGSEDGTIRVW-----DLRTGECVQ-----TL-SGHTNSVTSLAWSPdGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
440-920 3.74e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.42  E-value: 3.74e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  440 LALPQRQAECNRTVFRVHKGVKAFSFCRRKNLLVTGGLDRIIRVWNPyLPGKPTGVLRGHRAPVMYVHVAFEENKVFSMS 519
Cdd:COG2319     19 ALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDA-AAGALLATLLGHTAAVLSVAFSPDGRLLASAS 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  520 ADNTVKVWDLETHGCcctisskasgikgeltaclylpgpralcvatgtlaflhlkvgsvpeSHLVRSHQEPVVCCRYNPA 599
Cdd:COG2319     98 ADGTVRLWDLATGLL----------------------------------------------LRTLTGHTGAVRSVAFSPD 131

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  600 FRHVVSCCEASVVKVWDFETGRQVSEFIGTHGnaGITCLTFDSSGRRLVTGGRDGCLKIWSYNNGHCLHTLQHDENqsEV 679
Cdd:COG2319    132 GKTLASGSADGTVRLWDLATGKLLRTLTGHSG--AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG--AV 207

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  680 CDCTYmevNRNRCVIAVG-WDRRINVYfDIPRdfhhfRKPQphwqdDLNHGHKEDILCVAqcppF-----LLATSSYDGE 753
Cdd:COG2319    208 RSVAF---SPDGKLLASGsADGTVRLW-DLAT-----GKLL-----RTLTGHSGSVRSVA----FspdgrLLASGSADGT 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  754 IIVWNVISGHMYCKLntpspmdgqdhrEGPDRSVSQLAFlktrltkldSA-SAALISNGPGGSVCFWKLFSGSGLvanFT 832
Cdd:COG2319    270 VRLWDLATGELLRTL------------TGHSGGVNSVAF---------SPdGKLLASGSDDGTVRLWDLATGKLL---RT 325

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  833 PSREKAQVSGIVVTS-GDTLAYlADQHGFIHVYDIQEYGLQGTelqapntvtsWRAHVSMVTSLELIEGGSIVLSSSLDC 911
Cdd:COG2319    326 LTGHTGAVRSVAFSPdGKTLAS-GSDDGTVRLWDLATGELLRT----------LTGHTGAVTSVAFSPDGRTLASGSADG 394


                   ....*....
gi 1039771867  912 TVRLWSQDG 920
Cdd:COG2319    395 TVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 619-660 1.00e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 1.00e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1039771867   619 TGRQVSEFIGtHgNAGITCLTFDSSGRRLVTGGRDGCLKIWS 660
Cdd:smart00320    1 SGELLKTLKG-H-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
620-660 1.11e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 1.11e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1039771867  620 GRQVSEFIGtHgNAGITCLTFDSSGRRLVTGGRDGCLKIWS 660
Cdd:pfam00400    1 GKLLKTLEG-H-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
EF-hand_7 pfam13499
EF-hand domain pair;
113-177 1.31e-04

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 41.08  E-value: 1.31e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039771867  113 RLNALFQEHEKRGSQLLDMETFKCMMKQSLRSHSKSIGQIEQLFMKIDYEAVGRIQWDSFCTYLQ 177
Cdd:pfam13499    3 KLKEAFKLLDSDGDGYLDVEELKKLLRKLEEGEPLSDEEVEELFKEFDLDKDGRISFEEFLELYS 67
WD40 pfam00400
WD domain, G-beta repeat;
882-917 1.61e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.61e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1039771867  882 VTSWRAHVSMVTSLELIEGGSIVLSSSLDCTVRLWS 917
Cdd:pfam00400    4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 882-917 2.13e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 2.13e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1039771867   882 VTSWRAHVSMVTSLELIEGGSIVLSSSLDCTVRLWS 917
Cdd:smart00320    5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 450-758 9.44e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 146.33  E-value: 9.44e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  450 NRTVFRVH-KGVKAFSFCRRKNLLVTGGLDRIIRVWNpYLPGKPTGVLRGHRAPVMYVHVAFEENKVFSMSADNTVKVWD 528
Cdd:cd00200      1 LRRTLKGHtGGVTCVAFSPDGKLLATGSGDGTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  529 LETHGCCCTIsskaSGIKGELTACLYLPGPRALCVAT--GTLAFLHLKVGSvpESHLVRSHQEPVVCCRYNPAFRHVVSC 606
Cdd:cd00200     80 LETGECVRTL----TGHTSYVSSVAFSPDGRILSSSSrdKTIKVWDVETGK--CLTTLRGHTDWVNSVAFSPDGTFVASS 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  607 CEASVVKVWDFETGRQVSEFIGtHgNAGITCLTFDSSGRRLVTGGRDGCLKIWSYNNGHCLHTLQHDENQseVCDCTYME 686
Cdd:cd00200    154 SQDGTIKLWDLRTGKCVATLTG-H-TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG--VNSVAFSP 229

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039771867  687 VNRNrcVIAVGWDRRINVYfdiprDFHHFRKPQphwqdDLnHGHKEDILCVAQCP-PFLLATSSYDGEIIVWN 758
Cdd:cd00200    230 DGYL--LASGSEDGTIRVW-----DLRTGECVQ-----TL-SGHTNSVTSLAWSPdGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
440-920 3.74e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.42  E-value: 3.74e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  440 LALPQRQAECNRTVFRVHKGVKAFSFCRRKNLLVTGGLDRIIRVWNPyLPGKPTGVLRGHRAPVMYVHVAFEENKVFSMS 519
Cdd:COG2319     19 ALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDA-AAGALLATLLGHTAAVLSVAFSPDGRLLASAS 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  520 ADNTVKVWDLETHGCcctisskasgikgeltaclylpgpralcvatgtlaflhlkvgsvpeSHLVRSHQEPVVCCRYNPA 599
Cdd:COG2319     98 ADGTVRLWDLATGLL----------------------------------------------LRTLTGHTGAVRSVAFSPD 131

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  600 FRHVVSCCEASVVKVWDFETGRQVSEFIGTHGnaGITCLTFDSSGRRLVTGGRDGCLKIWSYNNGHCLHTLQHDENqsEV 679
Cdd:COG2319    132 GKTLASGSADGTVRLWDLATGKLLRTLTGHSG--AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG--AV 207

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  680 CDCTYmevNRNRCVIAVG-WDRRINVYfDIPRdfhhfRKPQphwqdDLNHGHKEDILCVAqcppF-----LLATSSYDGE 753
Cdd:COG2319    208 RSVAF---SPDGKLLASGsADGTVRLW-DLAT-----GKLL-----RTLTGHSGSVRSVA----FspdgrLLASGSADGT 269

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  754 IIVWNVISGHMYCKLntpspmdgqdhrEGPDRSVSQLAFlktrltkldSA-SAALISNGPGGSVCFWKLFSGSGLvanFT 832
Cdd:COG2319    270 VRLWDLATGELLRTL------------TGHSGGVNSVAF---------SPdGKLLASGSDDGTVRLWDLATGKLL---RT 325

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  833 PSREKAQVSGIVVTS-GDTLAYlADQHGFIHVYDIQEYGLQGTelqapntvtsWRAHVSMVTSLELIEGGSIVLSSSLDC 911
Cdd:COG2319    326 LTGHTGAVRSVAFSPdGKTLAS-GSDDGTVRLWDLATGELLRT----------LTGHTGAVTSVAFSPDGRTLASGSADG 394


                   ....*....
gi 1039771867  912 TVRLWSQDG 920
Cdd:COG2319    395 TVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 580-917 1.39e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.53  E-value: 1.39e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  580 ESHLVRSHQEPVVCCRYNPAFRHVVSCCEASVVKVWDFETGRQVSEFIGtHgNAGITCLTFDSSGRRLVTGGRDGCLKIW 659
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG-H-TGPVRDVAASADGTYLASGSSDKTIRLW 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  660 SYNNGHCLHTLQHDEnqSEVCDCTYMevNRNRCVIAVGWDRRINVYfdiprdfhHFRKPQPhwQDDLNhGHKEDILCVAQ 739
Cdd:cd00200     79 DLETGECVRTLTGHT--SYVSSVAFS--PDGRILSSSSRDKTIKVW--------DVETGKC--LTTLR-GHTDWVNSVAF 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  740 CP-PFLLATSSYDGEIIVWNvisghmyckLNTPSPMdgqdHR-EGPDRSVSQLAFLKTrltkldsaSAALISNGPGGSVC 817
Cdd:cd00200    144 SPdGTFVASSSQDGTIKLWD---------LRTGKCV----ATlTGHTGEVNSVAFSPD--------GEKLLSSSSDGTIK 202

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  818 FWKLFSGSgLVANFTPSREkaQVSGIVVTSGDTLAYLADQHGFIHVYDIQEYGLQGTeLQApntvtswraHVSMVTSLEL 897
Cdd:cd00200    203 LWDLSTGK-CLGTLRGHEN--GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT-LSG---------HTNSVTSLAW 269

                          330       340
                   ....*....|....*....|
gi 1039771867  898 IEGGSIVLSSSLDCTVRLWS 917
Cdd:cd00200    270 SPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 448-660 2.31e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.75  E-value: 2.31e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  448 ECNRTvFRVHKG-VKAFSFCRRKNLLVTGGLDRIIRVWNPyLPGKPTGVLRGHRAPVMyvHVAFEENK--VFSMSADNTV 524
Cdd:cd00200     84 ECVRT-LTGHTSyVSSVAFSPDGRILSSSSRDKTIKVWDV-ETGKCLTTLRGHTDWVN--SVAFSPDGtfVASSSQDGTI 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  525 KVWDLETHGCCCTISskasGIKGELTACLYLPGPRALCVAT--GTLAFLHLKVGSvpESHLVRSHQEPVVCCRYNPAFRH 602
Cdd:cd00200    160 KLWDLRTGKCVATLT----GHTGEVNSVAFSPDGEKLLSSSsdGTIKLWDLSTGK--CLGTLRGHENGVNSVAFSPDGYL 233

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1039771867  603 VVSCCEASVVKVWDFETGRQVSEFIGThgNAGITCLTFDSSGRRLVTGGRDGCLKIWS 660
Cdd:cd00200    234 LASGSEDGTIRVWDLRTGECVQTLSGH--TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 492-792 6.77e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.60  E-value: 6.77e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  492 PTGVLRGHRAPVMYVHVAFEENKVFSMSADNTVKVWDLETHGCCCTISSKASGIkgelTACLYLP-GPRALCVATGTLAF 570
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPV----RDVAASAdGTYLASGSSDKTIR 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  571 LHlKVGSVPESHLVRSHQEPVVCCRYNPAFRHVVSCCEASVVKVWDFETGRQVSEFIGtHgNAGITCLTFDSSGRRLVTG 650
Cdd:cd00200     77 LW-DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG-H-TDWVNSVAFSPDGTFVASS 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  651 GRDGCLKIWSYNNGHCLHTLQHdeNQSEVCDCTYMEvnRNRCVIAVGWDRRINVYfDIPRDFHHfrkpqphwqdDLNHGH 730
Cdd:cd00200    154 SQDGTIKLWDLRTGKCVATLTG--HTGEVNSVAFSP--DGEKLLSSSSDGTIKLW-DLSTGKCL----------GTLRGH 218

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039771867  731 KEDILCVAQCPP-FLLATSSYDGEIIVWNVISGHMYCKLntpspmdgqdhrEGPDRSVSQLAF 792
Cdd:cd00200    219 ENGVNSVAFSPDgYLLASGSEDGTIRVWDLRTGECVQTL------------SGHTNSVTSLAW 269
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 445-616 5.10e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 67.75  E-value: 5.10e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  445 RQAECNRTvFRVHKG-VKAFSFCRRKNLLVTGGLDRIIRVWNPYlPGKPTGVLRGHRAPVMYVHVAFEENKVFSMSADNT 523
Cdd:cd00200    165 RTGKCVAT-LTGHTGeVNSVAFSPDGEKLLSSSSDGTIKLWDLS-TGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGT 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039771867  524 VKVWDLETHGCCCTISskasgikgeltaclylpgpralcvatgtlaflhlkvgsvpeshlvrSHQEPVVCCRYNPAFRHV 603
Cdd:cd00200    243 IRVWDLRTGECVQTLS----------------------------------------------GHTNSVTSLAWSPDGKRL 276

                          170
                   ....*....|...
gi 1039771867  604 VSCCEASVVKVWD 616
Cdd:cd00200    277 ASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 619-660 1.00e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 1.00e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1039771867   619 TGRQVSEFIGtHgNAGITCLTFDSSGRRLVTGGRDGCLKIWS 660
Cdd:smart00320    1 SGELLKTLKG-H-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
620-660 1.11e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 1.11e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1039771867  620 GRQVSEFIGtHgNAGITCLTFDSSGRRLVTGGRDGCLKIWS 660
Cdd:pfam00400    1 GKLLKTLEG-H-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
EF-hand_7 pfam13499
EF-hand domain pair;
113-177 1.31e-04

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 41.08  E-value: 1.31e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039771867  113 RLNALFQEHEKRGSQLLDMETFKCMMKQSLRSHSKSIGQIEQLFMKIDYEAVGRIQWDSFCTYLQ 177
Cdd:pfam13499    3 KLKEAFKLLDSDGDGYLDVEELKKLLRKLEEGEPLSDEEVEELFKEFDLDKDGRISFEEFLELYS 67
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 489-528 2.11e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 2.11e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1039771867   489 PGKPTGVLRGHRAPVMYVHVAFEENKVFSMSADNTVKVWD 528
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 585-616 8.36e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 8.36e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1039771867   585 RSHQEPVVCCRYNPAFRHVVSCCEASVVKVWD 616
Cdd:smart00320    9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
882-917 1.61e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.61e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1039771867  882 VTSWRAHVSMVTSLELIEGGSIVLSSSLDCTVRLWS 917
Cdd:pfam00400    4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 882-917 2.13e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 2.13e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1039771867   882 VTSWRAHVSMVTSLELIEGGSIVLSSSLDCTVRLWS 917
Cdd:smart00320    5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 453-485 3.25e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 3.25e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1039771867   453 VFRVHKG-VKAFSFCRRKNLLVTGGLDRIIRVWN 485
Cdd:smart00320    7 TLKGHTGpVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
490-528 3.43e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 3.43e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1039771867  490 GKPTGVLRGHRAPVMYVHVAFEENKVFSMSADNTVKVWD 528
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 728-758 8.54e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 8.54e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1039771867   728 HGHKEDILCVAQCP-PFLLATSSYDGEIIVWN 758
Cdd:smart00320    9 KGHTGPVTSVAFSPdGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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