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Conserved domains on  [gi|1039768122|ref|XP_017175781|]
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zinc finger protein 69 isoform X3 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 18089501)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217|GO:0003700
PubMed:  8183940|22803940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
KRAB super family cl42959
krueppel associated box;
1-33 6.96e-10

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 54.52  E-value: 6.96e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1039768122    1 MLENYRNLVSVaGYQLSKPTVISQLEKGEGPCM 33
Cdd:smart00349  30 MLENYSNLVSL-GFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
120-351 1.02e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 1.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768122 120 NKLENPESSNVILEQKHRKHKPARKRNKYKLDSIDHPVSCmrARRYPCNVCEKMFKQPIHLVEHMRTHTG-EKPFRCKEC 198
Cdd:COG5048   218 QNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA--SESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQC 295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768122 199 GRAFSQSASLNTHQR--IHTGE--KPFACEE--CGKAFRHRSSLNQHHRTHTGEKPFTC--DKCQKAFSQNI-----SLV 265
Cdd:COG5048   296 NISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSL 375

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768122 266 QHLRTHSGEKPFSC--SECGKPFRQIRHLSEHVRIHTGEKP--YKCTSCCKTFSHRAYLTHHQRIHTGERPYKCkECGKA 341
Cdd:COG5048   376 QQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKS 454

                         250
                  ....*....|
gi 1039768122 342 FRQRIHLSNH 351
Cdd:COG5048   455 FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
375-400 6.77e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.77e-04
                          10        20
                  ....*....|....*....|....*.
gi 1039768122 375 SFKKHQRHHTGEKPYECTECGKSFSY 400
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
1-33 6.96e-10

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 54.52  E-value: 6.96e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1039768122    1 MLENYRNLVSVaGYQLSKPTVISQLEKGEGPCM 33
Cdd:smart00349  30 MLENYSNLVSL-GFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
120-351 1.02e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 1.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768122 120 NKLENPESSNVILEQKHRKHKPARKRNKYKLDSIDHPVSCmrARRYPCNVCEKMFKQPIHLVEHMRTHTG-EKPFRCKEC 198
Cdd:COG5048   218 QNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA--SESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQC 295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768122 199 GRAFSQSASLNTHQR--IHTGE--KPFACEE--CGKAFRHRSSLNQHHRTHTGEKPFTC--DKCQKAFSQNI-----SLV 265
Cdd:COG5048   296 NISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSL 375

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768122 266 QHLRTHSGEKPFSC--SECGKPFRQIRHLSEHVRIHTGEKP--YKCTSCCKTFSHRAYLTHHQRIHTGERPYKCkECGKA 341
Cdd:COG5048   376 QQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKS 454

                         250
                  ....*....|
gi 1039768122 342 FRQRIHLSNH 351
Cdd:COG5048   455 FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
179-204 1.33e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.33e-04
                          10        20
                  ....*....|....*....|....*.
gi 1039768122 179 HLVEHMRTHTGEKPFRCKECGRAFSQ 204
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
375-400 6.77e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.77e-04
                          10        20
                  ....*....|....*....|....*.
gi 1039768122 375 SFKKHQRHHTGEKPYECTECGKSFSY 400
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 329-409 7.80e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.55  E-value: 7.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768122 329 GERPYKCK--ECGKAFRQRIHLSNHRtVHtgvkayecNRCGKAYRHDSSFKKHQRHHTGEKPYECTECGKSFSYNSSLSR 406
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM-LH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1039768122 407 HQK 409
Cdd:COG5189   417 HRK 419
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
1-33 6.96e-10

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 54.52  E-value: 6.96e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1039768122    1 MLENYRNLVSVaGYQLSKPTVISQLEKGEGPCM 33
Cdd:smart00349  30 MLENYSNLVSL-GFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
120-351 1.02e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 1.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768122 120 NKLENPESSNVILEQKHRKHKPARKRNKYKLDSIDHPVSCmrARRYPCNVCEKMFKQPIHLVEHMRTHTG-EKPFRCKEC 198
Cdd:COG5048   218 QNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA--SESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQC 295

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768122 199 GRAFSQSASLNTHQR--IHTGE--KPFACEE--CGKAFRHRSSLNQHHRTHTGEKPFTC--DKCQKAFSQNI-----SLV 265
Cdd:COG5048   296 NISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSL 375

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768122 266 QHLRTHSGEKPFSC--SECGKPFRQIRHLSEHVRIHTGEKP--YKCTSCCKTFSHRAYLTHHQRIHTGERPYKCkECGKA 341
Cdd:COG5048   376 QQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKS 454

                         250
                  ....*....|
gi 1039768122 342 FRQRIHLSNH 351
Cdd:COG5048   455 FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
247-407 4.43e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 4.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768122 247 KPFTCDKCQKAFSQNISLVQHLRT--HSGE--KPFSCSE--CGKPFRQIRHLSEHVRIHTGEKPYKC--TSCCKTFS--- 315
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpll 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768122 316 ---HRAYLTHHQRIHTgERPYKC--KECGKAFRQRIHLSNHRTVHTGVKAYECN--RCGKAYRHDSSFKKHQRHHTgEKP 388
Cdd:COG5048   368 nnePPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHT-NHA 445

                         170
                  ....*....|....*....
gi 1039768122 389 YECTECGKSFSYNSSLSRH 407
Cdd:COG5048   446 PLLCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
179-204 1.33e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.33e-04
                          10        20
                  ....*....|....*....|....*.
gi 1039768122 179 HLVEHMRTHTGEKPFRCKECGRAFSQ 204
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
191-254 4.41e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 4.41e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039768122 191 KPFRCKECGRAFSQSASLNTHQRIHTGEKPFAC--EECGKAFRHRSSLNQHHRTHTGEKPFTCDKC 254
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKS 97
zf-H2C2_2 pfam13465
Zinc-finger double domain;
291-316 4.53e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.53e-04
                          10        20
                  ....*....|....*....|....*.
gi 1039768122 291 HLSEHVRIHTGEKPYKCTSCCKTFSH 316
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
375-400 6.77e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.77e-04
                          10        20
                  ....*....|....*....|....*.
gi 1039768122 375 SFKKHQRHHTGEKPYECTECGKSFSY 400
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
207-232 9.36e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.36e-04
                          10        20
                  ....*....|....*....|....*.
gi 1039768122 207 SLNTHQRIHTGEKPFACEECGKAFRH 232
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
235-260 2.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.09e-03
                          10        20
                  ....*....|....*....|....*.
gi 1039768122 235 SLNQHHRTHTGEKPFTCDKCQKAFSQ 260
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
323-344 2.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.20e-03
                          10        20
                  ....*....|....*....|..
gi 1039768122 323 HQRIHTGERPYKCKECGKAFRQ 344
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 389-411 7.62e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 7.62e-03
                          10        20
                  ....*....|....*....|...
gi 1039768122 389 YECTECGKSFSYNSSLSRHQKIH 411
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 329-409 7.80e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.55  E-value: 7.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768122 329 GERPYKCK--ECGKAFRQRIHLSNHRtVHtgvkayecNRCGKAYRHDSSFKKHQRHHTGEKPYECTECGKSFSYNSSLSR 406
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM-LH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1039768122 407 HQK 409
Cdd:COG5189   417 HRK 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
76-383 9.65e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.14  E-value: 9.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768122  76 EDDIVCSPLKKASSYSDTLESHRatcgkgtrraiwtHKKKRQEgNKLENPESSNVILEQKHRKHKPARKRNKYKLDSIDH 155
Cdd:COG5048    59 EKPSQCSYSGCDKSFSRPLELSR-------------HLRTHHN-NPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLS 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768122 156 PVSCMRARRYP--CNVCEKMFKQPIHLVEHMRTHTGEK-------PFRCKECGRAFSQSASLNTHQRIHTGEKPFACEEC 226
Cdd:COG5048   125 SHSLPPSSRDPqlPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSP 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768122 227 GKAFRHRSSLNQHHRTHTGEKPFTCDKCQKAFSQNISLVQHLRTHSGEKPFSCSECGKPFRQIRHLSEHVRIHTGE---- 302
Cdd:COG5048   205 LSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssek 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039768122 303 ---KPYKCTSCCKTFSHRAYLTHHQR--IHTGE--RPYKCKE--CGKAFRQRIHLSNHRTVHTGVKAYEC--NRCGKAYR 371
Cdd:COG5048   285 gfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFS 364

                         330
                  ....*....|..
gi 1039768122 372 HDSSFKKHQRHH 383
Cdd:COG5048   365 PLLNNEPPQSLQ 376
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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