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Conserved domains on  [gi|1039765245|ref|XP_017175263|]
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leucine-rich repeat and IQ domain-containing protein 3 isoform X3 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
4-124 1.50e-09

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.79  E-value: 1.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765245   4 GTITKELTSHEEWSHYNENIIEDQKDFVFVKYSGLHLKSM-ENLQTCISLRVCIFSNNFLTDI-QPLQSCKKLIKLDLHG 81
Cdd:COG4886    89 LTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSN 168

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1039765245  82 NQIKTLPDknFWSGLKNLKLLYLHDNGFSKLKNicVLSGCVSL 124
Cdd:COG4886   169 NQLTDLPE--ELGNLTNLKELDLSNNQITDLPE--PLGNLTNL 207
IQCG-IQCD super family cl49618
IQ (isoleucine-glutamine) motif containing G and D (IQCG and IQCD); IQCG and IQCD belong to ...
 219-243 3.67e-04

IQ (isoleucine-glutamine) motif containing G and D (IQCG and IQCD); IQCG and IQCD belong to the IQ motif-containing protein family which contain a C-terminal conserved IQ (isoleucine-glutamine) motif and a coiled-coil domain. The IQCG protein (also known as DRC9 and CFAP122) is essential for sperm flagellum formation in mice. The IQCD protein (also known as DRC10) is involved in sperm fertilization and the acrosome reaction. Both proteins are components of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility. IQCG and IQCD proteins contain a central coiled-coil domain and a C-terminal IQ (isoleucine-glutamine) motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, that interacts with calmodulin (CaM) in a calcium-independent manner. IQ motif-containing proteins that are known to bind calmodulin (CaM) have a wide diversity of biological functions, and they include neuronal growth proteins, myosins, voltage-operated channels, phosphatases, Ras exchange proteins, sperm surface proteins, Ras Gap-like proteins, spindle-associated proteins, and several proteins in plants.


The actual alignment was detected with superfamily member cd23766:

Pssm-ID: 483958  Cd Length: 40  Bit Score: 37.53  E-value: 3.67e-04
                          10        20
                  ....*....|....*....|....*
gi 1039765245 219 VLIIQRWIRGFIVRKHLSPYFKHKK 243
Cdd:cd23766    14 AIKIQAWWRGIMVRKGLGPFKKKKK 38
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-124 1.50e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.79  E-value: 1.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765245   4 GTITKELTSHEEWSHYNENIIEDQKDFVFVKYSGLHLKSM-ENLQTCISLRVCIFSNNFLTDI-QPLQSCKKLIKLDLHG 81
Cdd:COG4886    89 LTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSN 168

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1039765245  82 NQIKTLPDknFWSGLKNLKLLYLHDNGFSKLKNicVLSGCVSL 124
Cdd:COG4886   169 NQLTDLPE--ELGNLTNLKELDLSNNQITDLPE--PLGNLTNL 207
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 36-120 1.63e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 1.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765245  36 SGLHLKSMENLQTCISLRVCIFSNNFLTDIQPLQSCKKLIKLDLHGNQIKTLPdkNFwSGLKNLKLLYLHDNgfsklkNI 115
Cdd:cd21340    10 NDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIE--NL-ENLVNLKKLYLGGN------RI 80


                  ....*
gi 1039765245 116 CVLSG 120
Cdd:cd21340    81 SVVEG 85
LRR_8 pfam13855
Leucine rich repeat;
51-109 1.97e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 1.97e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039765245  51 SLRVCIFSNNFLTDIQP--LQSCKKLIKLDLHGNQIKTLPDKNFWsGLKNLKLLYLHDNGF 109
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGAFS-GLPSLRYLDLSGNRL 61
IQCG cd23766
IQ (isoleucine-glutamine) motif containing G (IQCG); IQCG, also called dynein regulatory ...
 219-243 3.67e-04

IQ (isoleucine-glutamine) motif containing G (IQCG); IQCG, also called dynein regulatory complex protein 9 (DRC9), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ (isoleucine-glutamine) motif and a coiled-coil domain. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The expression of IQCG is reduced in the sperm of human asthenospermia patients whose sperm have reduced mobility. It has also been shown to have a role in the calmodulin-mediated calcium signaling pathway in zebrafish haematopoietic development. The human IQCG gene was first reported to be involved in chromosome translocation in a case of acute lymphoid/myeloid leukemia. It expresses predominantly at mice testis during spermatogenesis which interacts with calmodulin in a calcium-dependent manner in the mouse testis. IQCG knockout mice are sterile due to the total immobility of their spermatozoa.


Pssm-ID: 467744  Cd Length: 40  Bit Score: 37.53  E-value: 3.67e-04
                          10        20
                  ....*....|....*....|....*
gi 1039765245 219 VLIIQRWIRGFIVRKHLSPYFKHKK 243
Cdd:cd23766    14 AIKIQAWWRGIMVRKGLGPFKKKKK 38
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-124 1.50e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.79  E-value: 1.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765245   4 GTITKELTSHEEWSHYNENIIEDQKDFVFVKYSGLHLKSM-ENLQTCISLRVCIFSNNFLTDI-QPLQSCKKLIKLDLHG 81
Cdd:COG4886    89 LTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSN 168

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1039765245  82 NQIKTLPDknFWSGLKNLKLLYLHDNGFSKLKNicVLSGCVSL 124
Cdd:COG4886   169 NQLTDLPE--ELGNLTNLKELDLSNNQITDLPE--PLGNLTNL 207
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 36-120 1.63e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 1.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765245  36 SGLHLKSMENLQTCISLRVCIFSNNFLTDIQPLQSCKKLIKLDLHGNQIKTLPdkNFwSGLKNLKLLYLHDNgfsklkNI 115
Cdd:cd21340    10 NDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIE--NL-ENLVNLKKLYLGGN------RI 80


                  ....*
gi 1039765245 116 CVLSG 120
Cdd:cd21340    81 SVVEG 85
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-135 4.38e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.25  E-value: 4.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765245  44 ENLQTCISLRVCIFSNNFLTDI-QPLQSCKKLIKLDLHGNQIKTLPDknfWSGLKNLKLLYLHDNGFSKLKNICVLSgcv 122
Cdd:COG4886   199 EPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPE---LGNLTNLEELDLSNNQLTDLPPLANLT--- 272

                          90
                  ....*....|...
gi 1039765245 123 SLIGLTMFDCPVS 135
Cdd:COG4886   273 NLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-113 2.85e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.94  E-value: 2.85e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039765245  40 LKSMENLQTcisLRVcifSNNFLTDIQPLQSCKKLIKLDLHGNQIKTLPDknfWSGLKNLKLLYLHDNGFSKLK 113
Cdd:COG4886   224 LANLTNLET---LDL---SNNQLTDLPELGNLTNLEELDLSNNQLTDLPP---LANLTNLKTLDLSNNQLTDLK 288
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 39-169 1.83e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 1.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765245  39 HLKSMENLQTCISLRVCIFSNNFLTDIQPLQSCKKLIKLDLHGNQIKT-------------------------------- 86
Cdd:cd21340    35 KITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVveglenltnleelhienqrlppgekltfdprs 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765245  87 -----------------LPDKNFWSGLKNLKLLYLHDNGFSKLKNIC-VLSGCVSLIGLTMFDCPVSLKKGYRHVLVNSI 148
Cdd:cd21340   115 laalsnslrvlnisgnnIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVCKKPKYRDKIILAS 194

                         170       180
                  ....*....|....*....|...
gi 1039765245 149 WPLKALDHHVISDEEI--IQNWR 169
Cdd:cd21340   195 KSLEVLDGKEITDTERqfLKRLK 217
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 57-124 6.93e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.32  E-value: 6.93e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039765245  57 FSNNFLTDIQPLQSCKKLIKLDLHGNQIKTLPDKNFwsgLKNLKLLYLHDNGFSKLKNicvLSGCVSL 124
Cdd:cd21340     9 LNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEF---LTNLTHLYLQNNQIEKIEN---LENLVNL 70
LRR_8 pfam13855
Leucine rich repeat;
51-109 1.97e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 1.97e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039765245  51 SLRVCIFSNNFLTDIQP--LQSCKKLIKLDLHGNQIKTLPDKNFWsGLKNLKLLYLHDNGF 109
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGAFS-GLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-128 1.56e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.00  E-value: 1.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765245  40 LKSMENLQTCISLRVCIFSNNFLTDIQPLQSCKKLIKLDLHGNQIKTLPDKNFWSGLKNLKLLYLHDNGFSKLKNICVLS 119
Cdd:COG4886   240 LTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLL 319


                  ....*....
gi 1039765245 120 GCVSLIGLT 128
Cdd:COG4886   320 LTTLLLLLL 328
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 51-89 3.39e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.61  E-value: 3.39e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1039765245  51 SLRVCIFSNNFLTDIQPLQSCKKLIKLDLHGN-QIKTLPD 89
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSD 41
IQCG cd23766
IQ (isoleucine-glutamine) motif containing G (IQCG); IQCG, also called dynein regulatory ...
 219-243 3.67e-04

IQ (isoleucine-glutamine) motif containing G (IQCG); IQCG, also called dynein regulatory complex protein 9 (DRC9), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ (isoleucine-glutamine) motif and a coiled-coil domain. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The expression of IQCG is reduced in the sperm of human asthenospermia patients whose sperm have reduced mobility. It has also been shown to have a role in the calmodulin-mediated calcium signaling pathway in zebrafish haematopoietic development. The human IQCG gene was first reported to be involved in chromosome translocation in a case of acute lymphoid/myeloid leukemia. It expresses predominantly at mice testis during spermatogenesis which interacts with calmodulin in a calcium-dependent manner in the mouse testis. IQCG knockout mice are sterile due to the total immobility of their spermatozoa.


Pssm-ID: 467744  Cd Length: 40  Bit Score: 37.53  E-value: 3.67e-04
                          10        20
                  ....*....|....*....|....*
gi 1039765245 219 VLIIQRWIRGFIVRKHLSPYFKHKK 243
Cdd:cd23766    14 AIKIQAWWRGIMVRKGLGPFKKKKK 38
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 36-88 9.65e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 9.65e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039765245  36 SGLHLKSMENLQTCISLRVCIFSNNFLTDI----QPLQSCKKLIKLDLHGNQIKTLP 88
Cdd:cd21340   128 SGNNIDSLEPLAPLRNLEQLDASNNQISDLeellDLLSSWPSLRELDLTGNPVCKKP 184
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 72-120 1.21e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 1.21e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1039765245  72 KKLIKLDLHGNQIKTLPdknFWSGLKNLKLLYLHDNgfSKLKNICVLSG 120
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP---PLAKLPNLETLDLSGN--NKITDLSDLAN 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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