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Conserved domains on  [gi|1039750927|ref|XP_017172432|]
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uroplakin-1b isoform X1 [Mus musculus]

Protein Classification

tetraspanin family protein( domain architecture ID 13626501)

tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

Gene Ontology:  GO:0005886
PubMed:  15763890|11756464|19709882|16024509
SCOP:  4001512

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 120-230 3.76e-32

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


:

Pssm-ID: 239409  Cd Length: 114  Bit Score: 114.17  E-value: 3.76e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039750927 120 LFLKQMLMRYQNNSPPTNDDEWKNNG--VTKTWDRLMLQDHCCGVNGPSDWQKYTSAFRvENNDADYPWPRQCCVMDKLK 197
Cdd:cd03156     3 LFFKKDLEDSFKNLLKNNYGNYNSTGdaITSTWNRVMIELKCCGVNGPTDFVDSTSFFR-QKNEPNSPYPESCCKRNSNS 81

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1039750927 198 EPLNLDACKLGVPGYYHSQGCYELISGPMDRHA 230
Cdd:cd03156    82 QIVDLDCPKLGSPNSYNKKGCYEKLSNPIERYA 114
Tetraspanin pfam00335
Tetraspanin family;
14-161 1.68e-07

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 50.01  E-value: 1.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039750927  14 LLIFGHVIVGMCGIALTAECIFFVSDQHSLYplleATNNDDIFGAAWIGMFVGICLFCLSVLAIVGIMKSNRKILLAYFI 93
Cdd:pfam00335   4 LLFLFNLLFWLLGLLLLGVGVWLLSAFSLLL----LGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFV 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039750927  94 MMFIVYGFEVASCITAATQRDffTTNLFLKQMLMRYQNNSppTNDDEWKNNGVTKTWDRLMLQDHCCG 161
Cdd:pfam00335  80 LLLLLFLAELAAGILAFVYRD--KLSGLLSNWLKKSLEDG--YRDWLDLYSCLNSALDSLQSEFGCCG 143
 
Name Accession Description Interval E-value
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 120-230 3.76e-32

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


Pssm-ID: 239409  Cd Length: 114  Bit Score: 114.17  E-value: 3.76e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039750927 120 LFLKQMLMRYQNNSPPTNDDEWKNNG--VTKTWDRLMLQDHCCGVNGPSDWQKYTSAFRvENNDADYPWPRQCCVMDKLK 197
Cdd:cd03156     3 LFFKKDLEDSFKNLLKNNYGNYNSTGdaITSTWNRVMIELKCCGVNGPTDFVDSTSFFR-QKNEPNSPYPESCCKRNSNS 81

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1039750927 198 EPLNLDACKLGVPGYYHSQGCYELISGPMDRHA 230
Cdd:cd03156    82 QIVDLDCPKLGSPNSYNKKGCYEKLSNPIERYA 114
Tetraspanin pfam00335
Tetraspanin family;
14-161 1.68e-07

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 50.01  E-value: 1.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039750927  14 LLIFGHVIVGMCGIALTAECIFFVSDQHSLYplleATNNDDIFGAAWIGMFVGICLFCLSVLAIVGIMKSNRKILLAYFI 93
Cdd:pfam00335   4 LLFLFNLLFWLLGLLLLGVGVWLLSAFSLLL----LGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFV 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039750927  94 MMFIVYGFEVASCITAATQRDffTTNLFLKQMLMRYQNNSppTNDDEWKNNGVTKTWDRLMLQDHCCG 161
Cdd:pfam00335  80 LLLLLFLAELAAGILAFVYRD--KLSGLLSNWLKKSLEDG--YRDWLDLYSCLNSALDSLQSEFGCCG 143
 
Name Accession Description Interval E-value
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 120-230 3.76e-32

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


Pssm-ID: 239409  Cd Length: 114  Bit Score: 114.17  E-value: 3.76e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039750927 120 LFLKQMLMRYQNNSPPTNDDEWKNNG--VTKTWDRLMLQDHCCGVNGPSDWQKYTSAFRvENNDADYPWPRQCCVMDKLK 197
Cdd:cd03156     3 LFFKKDLEDSFKNLLKNNYGNYNSTGdaITSTWNRVMIELKCCGVNGPTDFVDSTSFFR-QKNEPNSPYPESCCKRNSNS 81

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1039750927 198 EPLNLDACKLGVPGYYHSQGCYELISGPMDRHA 230
Cdd:cd03156    82 QIVDLDCPKLGSPNSYNKKGCYEKLSNPIERYA 114
Tetraspanin pfam00335
Tetraspanin family;
14-161 1.68e-07

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 50.01  E-value: 1.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039750927  14 LLIFGHVIVGMCGIALTAECIFFVSDQHSLYplleATNNDDIFGAAWIGMFVGICLFCLSVLAIVGIMKSNRKILLAYFI 93
Cdd:pfam00335   4 LLFLFNLLFWLLGLLLLGVGVWLLSAFSLLL----LGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFV 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039750927  94 MMFIVYGFEVASCITAATQRDffTTNLFLKQMLMRYQNNSppTNDDEWKNNGVTKTWDRLMLQDHCCG 161
Cdd:pfam00335  80 LLLLLFLAELAAGILAFVYRD--KLSGLLSNWLKKSLEDG--YRDWLDLYSCLNSALDSLQSEFGCCG 143
CD151_like_LEL cd03155
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. ...
 143-218 1.25e-06

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD151strongly associates with integrins, especially alpha3beta1, alpha6beta1, alpha7beta1, and alpha6beta4; it may play roles in cell-cell adhesion, cell migration, platelet aggregation, and angiogenesis. For example, CD151 is is involved in regulation of migration of neutrophils, endothelial cells, and various tumor cell lines; it associates specifically with laminin-binding integrins and strengthens alpha6beta1 integrin-mediated adhesion to laminin-1; CD151 also specifically attenuates adhesion-dependent activation of Ras and correspdonding downstream effects, and is involved in epithelial cell-cell adhesion as a modulator of PKC- and Cdc42-dependent actin cytoskeletal reorganization.


Pssm-ID: 239408 [Multi-domain]  Cd Length: 110  Bit Score: 46.19  E-value: 1.25e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039750927 143 NNGVTKTWDRLMLQDHCCGVNGPSDWQKytSAFRVENNDADYPWPRQCCvmdklKEPLNLDACKLGVPG--YYHSQGC 218
Cdd:cd03155    28 EEALTLTVDELQQEFKCCGSNNYTDWQD--SEWINSNEANGRLVPDSCC-----KTVVDRCGCLRDHPSniYKVEGGC 98
NET-5_like_LEL cd03165
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. ...
 122-230 4.45e-06

Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human tetraspan NET-5.


Pssm-ID: 239418 [Multi-domain]  Cd Length: 98  Bit Score: 44.28  E-value: 4.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039750927 122 LKQMLMRYQNNSPPtnddewknnGVTKTWDRLMLQDHCCGVNGPSDWQKYTSAFRVenndadypwPRQCCVMDKlkepln 201
Cdd:cd03165    15 LKEGLELYGTRNNR---------GLTNAWDITQTEFRCCGVTNYTDWYEVLGENRV---------PDSCCQEDS------ 70

                          90       100
                  ....*....|....*....|....*....
gi 1039750927 202 lDACKLGVPGYYHSQGCYELISGPMDRHA 230
Cdd:cd03165    71 -QDCGRNPTELWWKTGCYEKVQQWLVDNL 98
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 142-230 1.10e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 42.88  E-value: 1.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039750927 142 KNNGVTKTWDRLMLQDHCCGVNGPSDWQKYTSAFrvenndadypwPRQCCvmdklkeplnlDACKLGVPGYYHSQGCYEL 221
Cdd:cd03127    24 VDDDFQEAMDALQSTFECCGVNGPTDYLDLRLLV-----------PSSCC-----------KGTDGNCGLNLYTEGCLEK 81


                  ....*....
gi 1039750927 222 ISGPMDRHA 230
Cdd:cd03127    82 LVDFLRSNL 90
CD53_like_LEL cd03164
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. ...
 142-170 6.65e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD53 is a tetraspanin of the lymphoid-myeloid lineage and has been implicated in apoptosis protection. It associates with integrin alpha4beta1. Some of the cellular responses modulated by CD53 may be mediated by JNK activation and/or via the AKT pathway.


Pssm-ID: 239417 [Multi-domain]  Cd Length: 86  Bit Score: 40.54  E-value: 6.65e-05
                          10        20
                  ....*....|....*....|....*....
gi 1039750927 142 KNNGVTKTWDRLMLQDHCCGVNGPSDWQK 170
Cdd:cd03164    24 KDNNTSEAWDMIQSNLQCCGINGTTDWGS 52
TM4SF8_like_LEL cd03163
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. ...
 142-222 1.06e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 8 (TM4SF8) or Tspan-3 and related proteins. Tspan-3 has been reported to form a complex with integrin beta1 and OSP/claudin-11, which may be involved in oligodendrocyte proliferation and migration.


Pssm-ID: 239416  Cd Length: 105  Bit Score: 40.49  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039750927 142 KNNGV---TKTWDRLMLQDHCCGVNGPSDWQkYTSAFrveNNDADYPWPRQCCvmdklKEplNLDAC--KLGVPGYYHSQ 216
Cdd:cd03163    22 KYNGTnaeSRAVDYLQRQLQCCGIHNYTDWE-NTPWF---KESKNNSVPLSCC-----KE--TFTSCtgSLTQPKDLYQE 90


                  ....*.
gi 1039750927 217 GCYELI 222
Cdd:cd03163    91 GCEAKL 96
CD63_LEL cd03166
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins ...
 122-224 6.83e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD63 is present in platelets, neutrophils, and endothelial cells, amongst others. In platelets it associates with the integrin alphaIIBbeta3 and may modulate alphaIIbbeta3-dependent cytoskeletal reorganization.


Pssm-ID: 239419  Cd Length: 99  Bit Score: 38.23  E-value: 6.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039750927 122 LKQMLMRYQnnspptnddewKNNGVTKTWDRLMLQDHCCGVNGPSDWQKYTSAF--RVenndadypwPRQCCVmdklkep 199
Cdd:cd03166    15 FNQMISNYN-----------KTNDFRKILDRMQKDLKCCGANNYTDWENIPSLDtdSV---------PDSCCI------- 67

                          90       100
                  ....*....|....*....|....*..
gi 1039750927 200 lNLDA-CKLGVPG-YYHSQGCYELISG 224
Cdd:cd03166    68 -NVTKgCGINFDEkVIHLEGCVTKIEG 93
TM4SF2_6_like_LEL cd03161
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. ...
 137-228 9.65e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 2 (TM4SF2) or Tspan-7, transmembrane 4 superfamily 6 (TM4SF6) or Tspan-6, and related proteins. TM4SF2 has been identified as involved in some forms of X-linked mental retardation.


Pssm-ID: 239414  Cd Length: 104  Bit Score: 35.03  E-value: 9.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039750927 137 NDDEWKNNGVtktwDRLMLQDHCCGVNGPSDWqkytsafrvenNDADYPW----PRQCCVMDK---LKEPLNLDACKLGV 209
Cdd:cd03161    23 NGDDERSDAV----DTVQRTLHCCGVENYTDW-----------LNSPYFLekgiPLSCCKNRSdcsPQDLKNLTKAATKV 87

                          90
                  ....*....|....*....
gi 1039750927 210 pgyyHSQGCYELISGPMDR 228
Cdd:cd03161    88 ----YQQGCFTLVTSFMEA 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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