NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1039746197|ref|XP_017171514|]
View 

zinc finger SWIM domain-containing protein 8 isoform X7 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 519-672 2.96e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 44.76  E-value: 2.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746197 519 PYTALQPHLPcSPQYLTHPAHPAHPMPHM------PRPAVFPVPS--SAYPQGVHPAFLG------------AQYPYSVT 578
Cdd:pfam03154 358 PPTTPIPQLP-NPQSHKHPPHLSGPSPFQmnsnlpPPPALKPLSSlsTHHPPSAHPPPLQlmpqsqqlppppAQPPVLTQ 436

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746197 579 PPSLAATAVSFP-------VPSMAPITVHPYHTEPGLPLPTSVACEFRGQGAVSSVHPASTFPAIQGASLPALTTQPSPL 651
Cdd:pfam03154 437 SQSLPPPAASHPptsglhqVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPP 516

                         170       180
                  ....*....|....*....|...
gi 1039746197 652 VSGGFPPPE--EETHSQPVNPHS 672
Cdd:pfam03154 517 VQIKEEALDeaEEPESPPPPPRS 539
 
Name Accession Description Interval E-value
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 519-672 2.96e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 44.76  E-value: 2.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746197 519 PYTALQPHLPcSPQYLTHPAHPAHPMPHM------PRPAVFPVPS--SAYPQGVHPAFLG------------AQYPYSVT 578
Cdd:pfam03154 358 PPTTPIPQLP-NPQSHKHPPHLSGPSPFQmnsnlpPPPALKPLSSlsTHHPPSAHPPPLQlmpqsqqlppppAQPPVLTQ 436

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746197 579 PPSLAATAVSFP-------VPSMAPITVHPYHTEPGLPLPTSVACEFRGQGAVSSVHPASTFPAIQGASLPALTTQPSPL 651
Cdd:pfam03154 437 SQSLPPPAASHPptsglhqVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPP 516

                         170       180
                  ....*....|....*....|...
gi 1039746197 652 VSGGFPPPE--EETHSQPVNPHS 672
Cdd:pfam03154 517 VQIKEEALDeaEEPESPPPPPRS 539
PHA03247 PHA03247
large tegument protein UL36; Provisional
 514-670 3.34e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 3.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746197  514 SPGLHPYTALQPHLPCSPQYLTHPAHPAHPMPHMPRPAVFPVPSSAypqgvhPAFLGAQYPYSVTPPSLAATAVSFPVPS 593
Cdd:PHA03247  2770 APPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPA------AALPPAASPAGPLPPPTSAQPTAPPPPP 2843

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746197  594 MAPitvhpyhtEPGLPLPTSVA--CEFRGQGAVSSVHP---ASTFPAIQGASLPALTTQPSPLvsgGFPPPEEETHSQPV 668
Cdd:PHA03247  2844 GPP--------PPSLPLGGSVApgGDVRRRPPSRSPAAkpaAPARPPVRRLARPAVSRSTESF---ALPPDQPERPPQPQ 2912


                   ..
gi 1039746197  669 NP 670
Cdd:PHA03247  2913 AP 2914
 
Name Accession Description Interval E-value
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 519-672 2.96e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 44.76  E-value: 2.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746197 519 PYTALQPHLPcSPQYLTHPAHPAHPMPHM------PRPAVFPVPS--SAYPQGVHPAFLG------------AQYPYSVT 578
Cdd:pfam03154 358 PPTTPIPQLP-NPQSHKHPPHLSGPSPFQmnsnlpPPPALKPLSSlsTHHPPSAHPPPLQlmpqsqqlppppAQPPVLTQ 436

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746197 579 PPSLAATAVSFP-------VPSMAPITVHPYHTEPGLPLPTSVACEFRGQGAVSSVHPASTFPAIQGASLPALTTQPSPL 651
Cdd:pfam03154 437 SQSLPPPAASHPptsglhqVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPP 516

                         170       180
                  ....*....|....*....|...
gi 1039746197 652 VSGGFPPPE--EETHSQPVNPHS 672
Cdd:pfam03154 517 VQIKEEALDeaEEPESPPPPPRS 539
PHA03247 PHA03247
large tegument protein UL36; Provisional
 514-670 3.34e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 3.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746197  514 SPGLHPYTALQPHLPCSPQYLTHPAHPAHPMPHMPRPAVFPVPSSAypqgvhPAFLGAQYPYSVTPPSLAATAVSFPVPS 593
Cdd:PHA03247  2770 APPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPA------AALPPAASPAGPLPPPTSAQPTAPPPPP 2843

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746197  594 MAPitvhpyhtEPGLPLPTSVA--CEFRGQGAVSSVHP---ASTFPAIQGASLPALTTQPSPLvsgGFPPPEEETHSQPV 668
Cdd:PHA03247  2844 GPP--------PPSLPLGGSVApgGDVRRRPPSRSPAAkpaAPARPPVRRLARPAVSRSTESF---ALPPDQPERPPQPQ 2912


                   ..
gi 1039746197  669 NP 670
Cdd:PHA03247  2913 AP 2914
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 545-674 3.76e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.85  E-value: 3.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746197 545 PHMPRPAVFPVPSSAYPQGVHPAflgaqyPYSVTPPSLAATAVSFPVPSMAPITVHPyhTEPGLPLPTSVACEfrgqgav 624
Cdd:PRK14951  384 PEAAAPAAAPVAQAAAAPAPAAA------PAAAASAPAAPPAAAPPAPVAAPAAAAP--AAAPAAAPAAVALA------- 448

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1039746197 625 ssvhPASTFPAIQGASLPALTTQPSPLVSGGFPPPEEETHSQPVNPHSLH 674
Cdd:PRK14951  449 ----PAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEEG 494
PHA03247 PHA03247
large tegument protein UL36; Provisional
 515-670 9.13e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 9.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746197  515 PGLHPYTALQ--PHLPCSPQYLTHPAHPAHPMPHMPRPAVFPVPSSAYPQGVHPAFLGAQYPYSVTPPSLAATAVSFPVP 592
Cdd:PHA03247  2690 PTVGSLTSLAdpPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAP 2769

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039746197  593 smAPITVHPYHTEPGLPLPTSVACEFRGQGAVSSVHPASTfPAIQGASLPALTTQPSPlvSGGFPPPeeeTHSQPVNP 670
Cdd:PHA03247  2770 --APPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP-PAAVLAPAAALPPAASP--AGPLPPP---TSAQPTAP 2839
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH