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Conserved domains on  [gi|1039744922|ref|XP_017171183|]
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protein FAM81B isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
30-312 4.58e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.27  E-value: 4.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744922   30 QLEDRLSHQERTVAFLLEQAFRIKEDISaclhgsqgfrkEESLARKLLESHIQTITSIVKKLNQNIELLEDQIRIrdqvt 109
Cdd:TIGR02168  744 QLEERIAQLSKELTELEAEIEELEERLE-----------EAEEELAEAEAEIEELEAQIEQLKEELKALREALDE----- 807
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744922  110 tgTNFAVQDLNIKhiqgVGDLRGRVARCDSSIVKLSGDIQFIRHECRQMEKSVQELASALETISKNLDVKVMQLlgkiea 189
Cdd:TIGR02168  808 --LRAELTLLNEE----AANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESEL------ 875
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744922  190 sasEHTSNLKMVRgdyQHEMNLLEFKFNSLSKNIyEEVETnqkwtENQFIKYGKDHLshmneclkvvQEKLEKSENKMEE 269
Cdd:TIGR02168  876 ---EALLNERASL---EEALALLRSELEELSEEL-RELES-----KRSELRRELEEL----------REKLAQLELRLEG 933
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1039744922  270 KMLQLSSKLENFMNSQKQEAEInkVKTIENKVSKKMSQLEKRI 312
Cdd:TIGR02168  934 LEVRIDNLQERLSEEYSLTLEE--AEALENKIEDDEEEARRRL 974
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
30-312 4.58e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.27  E-value: 4.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744922   30 QLEDRLSHQERTVAFLLEQAFRIKEDISaclhgsqgfrkEESLARKLLESHIQTITSIVKKLNQNIELLEDQIRIrdqvt 109
Cdd:TIGR02168  744 QLEERIAQLSKELTELEAEIEELEERLE-----------EAEEELAEAEAEIEELEAQIEQLKEELKALREALDE----- 807
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744922  110 tgTNFAVQDLNIKhiqgVGDLRGRVARCDSSIVKLSGDIQFIRHECRQMEKSVQELASALETISKNLDVKVMQLlgkiea 189
Cdd:TIGR02168  808 --LRAELTLLNEE----AANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESEL------ 875
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744922  190 sasEHTSNLKMVRgdyQHEMNLLEFKFNSLSKNIyEEVETnqkwtENQFIKYGKDHLshmneclkvvQEKLEKSENKMEE 269
Cdd:TIGR02168  876 ---EALLNERASL---EEALALLRSELEELSEEL-RELES-----KRSELRRELEEL----------REKLAQLELRLEG 933
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1039744922  270 KMLQLSSKLENFMNSQKQEAEInkVKTIENKVSKKMSQLEKRI 312
Cdd:TIGR02168  934 LEVRIDNLQERLSEEYSLTLEE--AEALENKIEDDEEEARRRL 974
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
30-312 4.58e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.27  E-value: 4.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744922   30 QLEDRLSHQERTVAFLLEQAFRIKEDISaclhgsqgfrkEESLARKLLESHIQTITSIVKKLNQNIELLEDQIRIrdqvt 109
Cdd:TIGR02168  744 QLEERIAQLSKELTELEAEIEELEERLE-----------EAEEELAEAEAEIEELEAQIEQLKEELKALREALDE----- 807
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744922  110 tgTNFAVQDLNIKhiqgVGDLRGRVARCDSSIVKLSGDIQFIRHECRQMEKSVQELASALETISKNLDVKVMQLlgkiea 189
Cdd:TIGR02168  808 --LRAELTLLNEE----AANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESEL------ 875
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039744922  190 sasEHTSNLKMVRgdyQHEMNLLEFKFNSLSKNIyEEVETnqkwtENQFIKYGKDHLshmneclkvvQEKLEKSENKMEE 269
Cdd:TIGR02168  876 ---EALLNERASL---EEALALLRSELEELSEEL-RELES-----KRSELRRELEEL----------REKLAQLELRLEG 933
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1039744922  270 KMLQLSSKLENFMNSQKQEAEInkVKTIENKVSKKMSQLEKRI 312
Cdd:TIGR02168  934 LEVRIDNLQERLSEEYSLTLEE--AEALENKIEDDEEEARRRL 974
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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