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Conserved domains on  [gi|1039790226|ref|XP_017168360|]
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anoctamin-8 isoform X1 [Mus musculus]

Protein Classification

anoctamin family protein( domain architecture ID 10518511)

anoctamin family protein similar to anoctamin (anion channel with 8 transmembrane domains), which is a calcium-activated protein and may mediate the calcium-dependent exposure of phospholipids to the extracellular surface, a process called phospholipid scrambling

Gene Ontology:  GO:0005509|GO:0005254|GO:1902476
PubMed:  24692353|21607626|23532839|28724583|19015192
SCOP:  4004881
TCDB:  1.A.17

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
 237-443 1.06e-70

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


:

Pssm-ID: 461349  Cd Length: 377  Bit Score: 241.33  E-value: 1.06e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226  237 ICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTFTEAdqTSRDVSCVVFALFNVIWSTLFLEEWKRRGAELAYKWGTL 316
Cdd:pfam04547    1 IRDYFGEKIAFYFAFLGFYTKWLLPPAIVGLLVFLYGLA--TLFDPYTVFFAIFMSLWATLFLEFWKRREAELAYRWGTT 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226  317 DSpgEAVEEPRPQFRGI-RRISPITRAEEFYYPPWKRLLFQLLVSLPLC--LACLICVFILMlgcfqlqelvlsvkglpr 393
Cdd:pfam04547   79 GF--EEEEEPRPEFKGEkERINPVTGEKEPYYPPWKRRLRRYLLSIPLVllLIALLVLGVII------------------ 138

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1039790226  394 lvrFLPKVmlallvsvsaegYKKLAVWLNDMENYRLESTYERHLIIKVVL 443
Cdd:pfam04547  139 ---YLNFV------------YTKLAKKLTDWENHRTQSEYENSLILKVFL 173
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
 814-983 1.05e-68

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


:

Pssm-ID: 461349  Cd Length: 377  Bit Score: 235.94  E-value: 1.05e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226  814 RQKRHNRSSWIDPPEEEHSPQLTQAELESCMKKYEDtFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRSDAFKL 893
Cdd:pfam04547  211 KKKKKEEPSVSIKDEPEESEFLERVEKEYELEPYDG-LDDYLEMVIQFGYVTLFSAAFPLAPLFALLNNIIEIRSDAFKL 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226  894 CTGLQRPFGRRVESIGQWQKVMEAMGVLAIVVNCYLIGQCGQLQRLFPWlspeAAIVS-VVVLEHLALLVKYLIHVAIPD 972
Cdd:pfam04547  290 CTELRRPVPERADSIGPWLNILEFLSWLAVITNAALIYAFTSDQYWSLL----ALLLAfVIVFEHVVLLLKFLIAWLIPD 365

                          170
                   ....*....|.
gi 1039790226  973 IPGWVAEEMAK 983
Cdd:pfam04547  366 VPEWVRKERKR 376
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
1031-1210 4.93e-08

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK12323:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 700  Bit Score: 57.19  E-value: 4.93e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1031 GGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPVlrlkqiiplQTRPPAPTGCAPPPRSPADTRLPAFLSLR 1110
Cdd:PRK12323   370 GGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPA---------AAAAARAVAAAPARRSPAPEALAAARQAS 440

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1111 FLKAPERGPSPPRPGKLFAFSAREPSANGAPGGGARAHRSAGDEPAAAePEPRPEDagsasPPagcwrwdaPWgcGDNPP 1190
Cdd:PRK12323   441 ARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAA-PAPADDD-----PP--------PW--EELPP 504

                          170       180
                   ....*....|....*....|
gi 1039790226 1191 RVPADVPADAPAQPACWPTA 1210
Cdd:PRK12323   505 EFASPAPAQPDAAPAGWVAE 524
 
Name Accession Description Interval E-value
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
 237-443 1.06e-70

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


Pssm-ID: 461349  Cd Length: 377  Bit Score: 241.33  E-value: 1.06e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226  237 ICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTFTEAdqTSRDVSCVVFALFNVIWSTLFLEEWKRRGAELAYKWGTL 316
Cdd:pfam04547    1 IRDYFGEKIAFYFAFLGFYTKWLLPPAIVGLLVFLYGLA--TLFDPYTVFFAIFMSLWATLFLEFWKRREAELAYRWGTT 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226  317 DSpgEAVEEPRPQFRGI-RRISPITRAEEFYYPPWKRLLFQLLVSLPLC--LACLICVFILMlgcfqlqelvlsvkglpr 393
Cdd:pfam04547   79 GF--EEEEEPRPEFKGEkERINPVTGEKEPYYPPWKRRLRRYLLSIPLVllLIALLVLGVII------------------ 138

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1039790226  394 lvrFLPKVmlallvsvsaegYKKLAVWLNDMENYRLESTYERHLIIKVVL 443
Cdd:pfam04547  139 ---YLNFV------------YTKLAKKLTDWENHRTQSEYENSLILKVFL 173
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
 814-983 1.05e-68

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


Pssm-ID: 461349  Cd Length: 377  Bit Score: 235.94  E-value: 1.05e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226  814 RQKRHNRSSWIDPPEEEHSPQLTQAELESCMKKYEDtFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRSDAFKL 893
Cdd:pfam04547  211 KKKKKEEPSVSIKDEPEESEFLERVEKEYELEPYDG-LDDYLEMVIQFGYVTLFSAAFPLAPLFALLNNIIEIRSDAFKL 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226  894 CTGLQRPFGRRVESIGQWQKVMEAMGVLAIVVNCYLIGQCGQLQRLFPWlspeAAIVS-VVVLEHLALLVKYLIHVAIPD 972
Cdd:pfam04547  290 CTELRRPVPERADSIGPWLNILEFLSWLAVITNAALIYAFTSDQYWSLL----ALLLAfVIVFEHVVLLLKFLIAWLIPD 365

                          170
                   ....*....|.
gi 1039790226  973 IPGWVAEEMAK 983
Cdd:pfam04547  366 VPEWVRKERKR 376
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1031-1210 4.93e-08

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 57.19  E-value: 4.93e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1031 GGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPVlrlkqiiplQTRPPAPTGCAPPPRSPADTRLPAFLSLR 1110
Cdd:PRK12323   370 GGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPA---------AAAAARAVAAAPARRSPAPEALAAARQAS 440

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1111 FLKAPERGPSPPRPGKLFAFSAREPSANGAPGGGARAHRSAGDEPAAAePEPRPEDagsasPPagcwrwdaPWgcGDNPP 1190
Cdd:PRK12323   441 ARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAA-PAPADDD-----PP--------PW--EELPP 504

                          170       180
                   ....*....|....*....|
gi 1039790226 1191 RVPADVPADAPAQPACWPTA 1210
Cdd:PRK12323   505 EFASPAPAQPDAAPAGWVAE 524
KLF14_N cd21576
N-terminal domain of Kruppel-like factor 14; Kruppel-like factor 14 (KLF14; also known as ...
 1043-1212 3.58e-03

N-terminal domain of Kruppel-like factor 14; Kruppel-like factor 14 (KLF14; also known as Krueppel-like factor 14 or basic transcription element-binding protein 5/BTEB5) is a protein that in humans is encoded by the KLF14 gene. KLF14 regulates the transcription of various genes, including TGFbetaRII (the type II receptor for TGFbeta). KLF14 is expressed in many tissues, lacks introns, and is subject to parent-specific expression. It also appears to be a master regulator of gene expression in adipose tissue. KLF14 is associated with coronary artery disease, hypercholesterolemia, and type 2 diabetes. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF14 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF14.


Pssm-ID: 409238 [Multi-domain]  Cd Length: 195  Bit Score: 40.19  E-value: 3.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1043 PDPVAERGAAKAKGSERPRRPgALLPPGPvlRLKQIIPLQTRPPAPtgcaPPPRSPADTRLPAFLSLRFLK--APERGPS 1120
Cdd:cd21576     29 PDPEGAGGAAGSEVGAAPPES-ALPGPGP--PGPAWVPPLLQVPAP----SPGAGGAAPHLLAASVLADLRggAGEGSRE 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1121 PPRPGKLFAFSAREPSANGAPGGGARAHRSAGDEpAAAEPEPRPEDAGSASPPAGCWRWDAPWGCGDNPPRV-PADVPAD 1199
Cdd:cd21576    102 DSGEAPRASSGSSDPARGSSPTLGSEPAPASGED-AVSGPESSFGAPAIPSAPAAPGAPAVSGEVPGGAPGAgPAPAAGP 180

                          170
                   ....*....|....
gi 1039790226 1200 APAQPACWPTA-RH 1212
Cdd:cd21576    181 APRRRPVTPAAkRH 194
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 1020-1175 6.03e-03

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 40.82  E-value: 6.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1020 AEQQARRERDTGGREEARAEAPGPDPVAERGAAKAKGSERP-RRPGALLPPGPVLRLKQIIPLQTRPPAPTG-----CAP 1093
Cdd:COG5180    208 DEAQEEPPDLTGGADHPRPEAASSPKVDPPSTSEARSRPATvDAQPEMRPPADAKERRRAAIGDTPAAEPPGlpvleAGS 287

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1094 PPRS---PADTRLPAFLSLRFLKAPERGPSPPRPGKLFAFSAREPSANGAPgggarahrsAGDEPAAAEPEPRPedagSA 1170
Cdd:COG5180    288 EPQSdapEAETARPIDVKGVASAPPATRPVRPPGGARDPGTPRPGQPTERP---------AGVPEAASDAGQPP----SA 354


                   ....*
gi 1039790226 1171 SPPAG 1175
Cdd:COG5180    355 YPPAE 359
 
Name Accession Description Interval E-value
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
 237-443 1.06e-70

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


Pssm-ID: 461349  Cd Length: 377  Bit Score: 241.33  E-value: 1.06e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226  237 ICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTFTEAdqTSRDVSCVVFALFNVIWSTLFLEEWKRRGAELAYKWGTL 316
Cdd:pfam04547    1 IRDYFGEKIAFYFAFLGFYTKWLLPPAIVGLLVFLYGLA--TLFDPYTVFFAIFMSLWATLFLEFWKRREAELAYRWGTT 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226  317 DSpgEAVEEPRPQFRGI-RRISPITRAEEFYYPPWKRLLFQLLVSLPLC--LACLICVFILMlgcfqlqelvlsvkglpr 393
Cdd:pfam04547   79 GF--EEEEEPRPEFKGEkERINPVTGEKEPYYPPWKRRLRRYLLSIPLVllLIALLVLGVII------------------ 138

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1039790226  394 lvrFLPKVmlallvsvsaegYKKLAVWLNDMENYRLESTYERHLIIKVVL 443
Cdd:pfam04547  139 ---YLNFV------------YTKLAKKLTDWENHRTQSEYENSLILKVFL 173
Anoctamin pfam04547
Calcium-activated chloride channel; The family carries eight putative transmembrane domains, ...
 814-983 1.05e-68

Calcium-activated chloride channel; The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.


Pssm-ID: 461349  Cd Length: 377  Bit Score: 235.94  E-value: 1.05e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226  814 RQKRHNRSSWIDPPEEEHSPQLTQAELESCMKKYEDtFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIRSDAFKL 893
Cdd:pfam04547  211 KKKKKEEPSVSIKDEPEESEFLERVEKEYELEPYDG-LDDYLEMVIQFGYVTLFSAAFPLAPLFALLNNIIEIRSDAFKL 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226  894 CTGLQRPFGRRVESIGQWQKVMEAMGVLAIVVNCYLIGQCGQLQRLFPWlspeAAIVS-VVVLEHLALLVKYLIHVAIPD 972
Cdd:pfam04547  290 CTELRRPVPERADSIGPWLNILEFLSWLAVITNAALIYAFTSDQYWSLL----ALLLAfVIVFEHVVLLLKFLIAWLIPD 365

                          170
                   ....*....|.
gi 1039790226  973 IPGWVAEEMAK 983
Cdd:pfam04547  366 VPEWVRKERKR 376
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1031-1210 4.93e-08

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 57.19  E-value: 4.93e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1031 GGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPVlrlkqiiplQTRPPAPTGCAPPPRSPADTRLPAFLSLR 1110
Cdd:PRK12323   370 GGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPA---------AAAAARAVAAAPARRSPAPEALAAARQAS 440

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1111 FLKAPERGPSPPRPGKLFAFSAREPSANGAPGGGARAHRSAGDEPAAAePEPRPEDagsasPPagcwrwdaPWgcGDNPP 1190
Cdd:PRK12323   441 ARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAA-PAPADDD-----PP--------PW--EELPP 504

                          170       180
                   ....*....|....*....|
gi 1039790226 1191 RVPADVPADAPAQPACWPTA 1210
Cdd:PRK12323   505 EFASPAPAQPDAAPAGWVAE 524
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1019-1210 3.83e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.94  E-value: 3.83e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1019 HAEQQARRERDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPVLRLKQIIPlqtrPPAPTGCAPPPRSP 1098
Cdd:PHA03247  2642 PPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPP----PPPTPEPAPHALVS 2717

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1099 ADTRLPAFLSLR-FLKAPERGPSPPRPGKLFAF------SAREPSANGAPGGGARAHRSAGDEPAAAEPEPRPEDAGSAS 1171
Cdd:PHA03247  2718 ATPLPPGPAAARqASPALPAAPAPPAVPAGPATpggparPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRES 2797

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1039790226 1172 PPAGcwrWDAPWGCGDNPPRVPADVPADAPAQPACWPTA 1210
Cdd:PHA03247  2798 LPSP---WDPADPPAAVLAPAAALPPAASPAGPLPPPTS 2833
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 1113-1210 2.91e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 51.53  E-value: 2.91e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1113 KAPERGPSPPRPGKLFAFSAREPSANGAPGGGARAHRSAGD-EPAAAEPEPRPEDAGSASPPAGCWRWDAPWGCGDNPPR 1191
Cdd:PRK07764   593 GAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAaAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAK 672

                           90
                   ....*....|....*....
gi 1039790226 1192 VPADVPADAPAQPACWPTA 1210
Cdd:PRK07764   673 AGGAAPAAPPPAPAPAAPA 691
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 1020-1209 3.31e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 51.53  E-value: 3.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1020 AEQQARRERDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPvlrlkqiiPLQTRPPAPTGCAPPPRSPA 1099
Cdd:PRK07764   600 PPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPE--------HHPKHVAVPDASDGGDGWPA 671

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1100 DTRLPAFLSlrflkAPERGPSPPRPGklfafSAREPSANGAPGGGARAHRSAGDEPAAAEP-------EPRPEDAGSASP 1172
Cdd:PRK07764   672 KAGGAAPAA-----PPPAPAPAAPAA-----PAGAAPAQPAPAPAATPPAGQADDPAAQPPqaaqgasAPSPAADDPVPL 741

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1039790226 1173 PAGCWRWDAPWGCGDNPPRVPADVPADAPAQPACWPT 1209
Cdd:PRK07764   742 PPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSP 778
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1040-1210 7.37e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 7.37e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1040 APGPDPVA----ERGAAKAKGSERPRRPgallPPGPVLRLKQIIPLQTRPPAPTGCAPPPRSPADTrlPAFLSLRFLKAP 1115
Cdd:PHA03247  2628 PPSPSPAAnepdPHPPPTVPPPERPRDD----PAPGRVSRPRRARRLGRAAQASSPPQRPRRRAAR--PTVGSLTSLADP 2701

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1116 ERGPSPPRPgklfafsAREPSANGAPGGGARAHRSAGDEPAAAEPEPRPEDAGSASP--PAGCWRWDAPWG-CGDNPPRV 1192
Cdd:PHA03247  2702 PPPPPTPEP-------APHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPggPARPARPPTTAGpPAPAPPAA 2774

                          170
                   ....*....|....*...
gi 1039790226 1193 PADVPADAPAQPACWPTA 1210
Cdd:PHA03247  2775 PAAGPPRRLTRPAVASLS 2792
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1023-1177 8.63e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 50.26  E-value: 8.63e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1023 QARRERDTGGREEARAEAPGPDPVAERGAAKAKGSerPRRPGALLPPGPVLRLkqiiPLQTRPPAPTGCAPPPRSPADTR 1102
Cdd:PRK12323   434 AAARQASARGPGGAPAPAPAPAAAPAAAARPAAAG--PRPVAAAAAAAPARAA----PAAAPAPADDDPPPWEELPPEFA 507

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039790226 1103 LPAFLSLRFLKAPERGPSPPRPGKLFAFSAREPSANGAPGGGARAhRSAGDEPAAAEPEPRPEDAGSASPPAGCW 1177
Cdd:PRK12323   508 SPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPR-AAAATEPVVAPRPPRASASGLPDMFDGDW 581
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1023-1205 9.82e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 9.82e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1023 QARRERDTGGREEARAEAPGPDPVAERGAAKAkgSERPRRPGALLPPGPVLRlkqiiPLQTRPPAP-TGCAPPPRSPADT 1101
Cdd:PHA03247  2583 TSRARRPDAPPQSARPRAPVDDRGDPRGPAPP--SPLPPDTHAPDPPPPSPS-----PAANEPDPHpPPTVPPPERPRDD 2655

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1102 RLPAFLSLrflkaPERGPSPPRPGKLFAfSAREPSANGAPGGGARAHRSAGDEPAAAEPEPRPEDAGSASP-PAGcwrwd 1180
Cdd:PHA03247  2656 PAPGRVSR-----PRRARRLGRAAQASS-PPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPlPPG----- 2724

                          170       180
                   ....*....|....*....|....*
gi 1039790226 1181 APWGCGDNPPRVPADVPADAPAQPA 1205
Cdd:PHA03247  2725 PAAARQASPALPAAPAPPAVPAGPA 2749
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1030-1205 1.06e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 49.85  E-value: 1.06e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1030 TGGREEARAEAPGPDPVAeRGAAKAKGSERPRRPGALLPPGPVLRlkqiiPLQTRPPAPTGCAPPPRSPAD-------TR 1102
Cdd:PRK07003   368 PGGGVPARVAGAVPAPGA-RAAAAVGASAVPAVTAVTGAAGAALA-----PKAAAAAAATRAEAPPAAPAPpatadrgDD 441

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1103 LPAFLSLRFLKAPERGPSPPRPGKLFAFSAREPSANGAPGGGARAHRSAGDEPAAAEPEPR-PEDAGSASPPAGCWRWDA 1181
Cdd:PRK07003   442 AADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAAtPAAVPDARAPAAASREDA 521

                          170       180
                   ....*....|....*....|....
gi 1039790226 1182 PwgcgdNPPRVPAdvPADAPAQPA 1205
Cdd:PRK07003   522 P-----AAAAPPA--PEARPPTPA 538
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 1030-1205 2.22e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 48.83  E-value: 2.22e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1030 TGGREEARAEApGPDPVAERGAAKAKGSERPRRPGALLPPGPVlrlkqiIPLQTRPPAPTGCAPPPRSPADTRLPAFLSL 1109
Cdd:PRK07764   578 LGGDWQVEAVV-GPAPGAAGGEGPPAPASSGPPEEAARPAAPA------APAAPAAPAPAGAAAAPAEASAAPAPGVAAP 650

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1110 RFLKAPERGPSPPRPGKLFAFSAREPSANGAPGGGARAHRSAGDEPAAAEPEPRP------------------EDAGSAS 1171
Cdd:PRK07764   651 EHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPaatppagqaddpaaqppqAAQGASA 730

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1039790226 1172 PPAGCWR--------WDAPWGCGDNPPRVPADVPADAPAQPA 1205
Cdd:PRK07764   731 PSPAADDpvplppepDDPPDPAGAPAQPPPPPAPAPAAAPAA 772
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1036-1209 2.91e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 2.91e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1036 ARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPVLRLKQIIPLQTRPPAPTGCAPPPRSPADTR-------LPAFLS 1108
Cdd:PHA03247  2772 PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTApppppgpPPPSLP 2851

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1109 LRFLKAP-----ERGPSPPRPGKLfAFSAREPSANGAPGGGARAHRSAGDEPAAAEPEPRPEDAGSASPPAGCWRWDAPW 1183
Cdd:PHA03247  2852 LGGSVAPggdvrRRPPSRSPAAKP-AAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQ 2930

                          170       180
                   ....*....|....*....|....*.
gi 1039790226 1184 GCGDNPPRVPADVPADAPAQPACWPT 1209
Cdd:PHA03247  2931 PPPPPPPRPQPPLAPTTDPAGAGEPS 2956
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1036-1205 3.30e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 3.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1036 ARAEAPGPDPVAERGAAKAKGSERPRRP----GALLPPGPVLRLKQiiplqTRPPAPTGCAPP-PRSPADTRLPAFLSLR 1110
Cdd:PHA03247  2822 ASPAGPLPPPTSAQPTAPPPPPGPPPPSlplgGSVAPGGDVRRRPP-----SRSPAAKPAAPArPPVRRLARPAVSRSTE 2896

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1111 FLKAPERGPSPPRPGKLfAFSAREPSANGAPGGGARAHRSAGDEPAAAEPEPRPEDAGSASPPAgcwrwDAPWGCGDNPP 1190
Cdd:PHA03247  2897 SFALPPDQPERPPQPQA-PPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAV-----PQPWLGALVPG 2970

                          170
                   ....*....|....*...
gi 1039790226 1191 RVPA---DVPADAPAQPA 1205
Cdd:PHA03247  2971 RVAVprfRVPQPAPSREA 2988
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 1033-1211 5.01e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 47.67  E-value: 5.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1033 REEARAEAPGPDPVAERGAAKAKGSERPRRPGallppgpvlrlkqiiplqtrPPAPTGCAPPPRSPADTRLPAflslrfl 1112
Cdd:PRK07764   380 RLERRLGVAGGAGAPAAAAPSAAAAAPAAAPA--------------------PAAAAPAAAAAPAPAAAPQPA------- 432

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1113 KAPERGPSPPrpgklfafSAREPSANGAPGGGARAhrsagdepAAAEPEPRPEDAGSASPPAGCWRWDAPWGCGDNPPRV 1192
Cdd:PRK07764   433 PAPAPAPAPP--------SPAGNAPAGGAPSPPPA--------AAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAA 496

                          170       180
                   ....*....|....*....|....
gi 1039790226 1193 PADVPADAPAQPAC-----WPTAR 1211
Cdd:PRK07764   497 PAAPAAPAGADDAAtlrerWPEIL 520
PHA03378 PHA03378
EBNA-3B; Provisional
 1041-1210 5.77e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 47.37  E-value: 5.77e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1041 PGPD--PVAERGAAKAKGSERPRRPGALLPPGP-VLRLKQIIPLQTRPP--APTgCAPPPRSPADTRLPaflslrflkaP 1115
Cdd:PHA03378   649 PTPHqpPQVEITPYKPTWTQIGHIPYQPSPTGAnTMLPIQWAPGTMQPPprAPT-PMRPPAAPPGRAQR----------P 717

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1116 ERGPSPPRPGKLFAFSAREPSanGAPGggaRAHRSAGDEPAAAEPEPRPedaGSASPPAGCWRWDAPWGCGDNPPrVPAD 1195
Cdd:PHA03378   718 AAATGRARPPAAAPGRARPPA--AAPG---RARPPAAAPGRARPPAAAP---GRARPPAAAPGAPTPQPPPQAPP-APQQ 788

                          170
                   ....*....|....*...
gi 1039790226 1196 VPADAPA---QPACWPTA 1210
Cdd:PHA03378   789 RPRGAPTpqpPPQAGPTS 806
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1044-1210 1.05e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 46.77  E-value: 1.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1044 DPVAERGAAKAkGSERPRRPGALLPPGPV---LRLKQIIPLQTRPPAPTGCAPPPRS--PADTRLPAflslrflkAPERG 1118
Cdd:PRK07003   359 EPAVTGGGAPG-GGVPARVAGAVPAPGARaaaAVGASAVPAVTAVTGAAGAALAPKAaaAAAATRAE--------APPAA 429

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1119 PSPPRPGKlfafSAREPSANGAPGGGARAHRSAGDEPAAAEPEPRPEDAGSASPPAGCWRWDAPWgcgdnPPRVPADVPA 1198
Cdd:PRK07003   430 PAPPATAD----RGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAF-----EPAPRAAAPS 500

                          170
                   ....*....|..
gi 1039790226 1199 DAPAQPACWPTA 1210
Cdd:PRK07003   501 AATPAAVPDARA 512
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1020-1211 1.10e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 46.38  E-value: 1.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1020 AEQQARRERDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPvlRLKQIIPLQTRPPAPTGCAPPPRSPA 1099
Cdd:PRK07003   423 AEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADS--GSASAPASDAPPDAAFEPAPRAAAPS 500

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1100 DTRLPAFLSLRFLKAPERGPSPPRPGKLFAFSAREPSANGAP---GGGARAH----RSAG-----DEPAAAEPEPRPEDA 1167
Cdd:PRK07003   501 AATPAAVPDARAPAAASREDAPAAAAPPAPEARPPTPAAAAPaarAGGAAAAldvlRNAGmrvssDRGARAAAAAKPAAA 580

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1039790226 1168 GSASPPAGcwrwdapwgcgdnPPRVPADVPadAPAQPACWPTAR 1211
Cdd:PRK07003   581 PAAAPKPA-------------APRVAVQVP--TPRARAATGDAP 609
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1033-1209 1.12e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.41  E-value: 1.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1033 REEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPVLrlkqiiplQTRPPAPtgcapPPRSPADTRLPAflSLRFL 1112
Cdd:PRK12323   420 AAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAA--------AARPAAA-----GPRPVAAAAAAA--PARAA 484

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1113 KAPERGPSPPR-------PGKLFAFSAREPSANGAPGGGARAHRSAGDEPAAAEPEPRPEDAGSASPPAgcwrwDAPwgc 1185
Cdd:PRK12323   485 PAAAPAPADDDpppweelPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRA-----AAA--- 556

                          170       180       190
                   ....*....|....*....|....*....|
gi 1039790226 1186 gdnPPRVPADVPADA------PAQPACWPT 1209
Cdd:PRK12323   557 ---TEPVVAPRPPRAsasglpDMFDGDWPA 583
PHA03379 PHA03379
EBNA-3A; Provisional
 1021-1203 1.20e-04

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 46.59  E-value: 1.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1021 EQQARRERDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGA--LLPPGPVLRLKQIIP--LQTRPPAPTgcapPPR 1096
Cdd:PHA03379   403 EALEKASEPTYGTPRPPVEKPRPEVPQSLETATSHGSAQVPEPPPvhDLEPGPLHDQHSMAPcpVAQLPPGPL----QDL 478

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1097 SPADtRLPAFLslrflKAPERGPSP-PRPGKLFAfSAREPSANGAPGGGARAHRSagdEPAAAEPEPRP----EDAGSAS 1171
Cdd:PHA03379   479 EPGD-QLPGVV-----QDGRPACAPvPAPAGPIV-RPWEASLSQVPGVAFAPVMP---QPMPVEPVPVPtvalERPVCPA 548

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1039790226 1172 PPAGCW--------------RW-DAPWgcGDNPPRVPADVPA-DAPAQ 1203
Cdd:PHA03379   549 PPLIAMqgpgetsgivrvreRWrPAPW--TPNPPRSPSQMSVrDRLAR 594
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1033-1208 1.32e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.32  E-value: 1.32e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1033 REEARAEAPGPDPVAERGAAKAKGSERPRRPGA----LLPPGPVLRLKQIIPLQTRPPAPTGCAPPPRSPADTRLPAfls 1108
Cdd:PHA03307   270 WEASGWNGPSSRPGPASSSSSPRERSPSPSPSSpgsgPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPS--- 346

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1109 lrflkaPERGPSPPRPgklfafsaREPSANGAPGGGARAHRSAGdEPAAAEPEPRPEDAGSASPPAGCWRWDAPWGCGDN 1188
Cdd:PHA03307   347 ------PSRSPSPSRP--------PPPADPSSPRKRPRPSRAPS-SPAASAGRPTRRRARAAVAGRARRRDATGRFPAGR 411

                          170       180
                   ....*....|....*....|
gi 1039790226 1189 PPRVPADVPADAPAQPACWP 1208
Cdd:PHA03307   412 PRPSPLDAGAASGAFYARYP 431
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 1019-1175 1.45e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.13  E-value: 1.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1019 HAEQQARRERDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGAllpPGPvlrlkqiiPLQTRPPAPTGCAPPPRSP 1098
Cdd:PRK07764   656 HVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPA---PAP--------AATPPAGQADDPAAQPPQA 724

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039790226 1099 ADTRLPAFLSlrflkAPERGPSPPRPGKLFAFSAREPSANGAPGGGARAhrSAGDEPAAAEPEPRPEDAGSASPPAG 1175
Cdd:PRK07764   725 AQGASAPSPA-----ADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAA--APAAAPPPSPPSEEEEMAEDDAPSMD 794
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1036-1211 1.75e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 1.75e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1036 ARAEAPGPDP----------VAERGAAKAKGSERPRRPGALLPP----GPVLRLKQIIPlqTRPPAPTG--CAPPPRSPA 1099
Cdd:PHA03247  2699 ADPPPPPPTPepaphalvsaTPLPPGPAAARQASPALPAAPAPPavpaGPATPGGPARP--ARPPTTAGppAPAPPAAPA 2776

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1100 DTRLPAflslrflkAPERGPSPPRPGKLFAFSAREPSANGAPGGGARAHRSAGDEPAAAEPEP-RPEDAGSASPPAGCWR 1178
Cdd:PHA03247  2777 AGPPRR--------LTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPtSAQPTAPPPPPGPPPP 2848

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1039790226 1179 WDAPWGC----GDNPPRVPADVPADAPAQPACWPTAR 1211
Cdd:PHA03247  2849 SLPLGGSvapgGDVRRRPPSRSPAAKPAAPARPPVRR 2885
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 1020-1204 1.87e-04

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 45.33  E-value: 1.87e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1020 AEQQARRERDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPVlrlkQIIPLQTRPPAPTGCAPPPRSPA 1099
Cdd:PTZ00436   173 ARKQELRKREKDRERARREDAAAAAAAKQKAAAKKAAAPSGKKSAKAAAPAKA----AAAPAKAAAPPAKAAAAPAKAAA 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1100 DTRLPAFLSLRFLKAPERGPSPPRPGKLFAFSAREPSANGA--PGGGARAHRSAGDEPAAAEPEPrpedAGSASPPAgcw 1177
Cdd:PTZ00436   249 APAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAapPAKAAAAPAKAAAAPAKAAAAP----AKAAAPPA--- 321

                          170       180
                   ....*....|....*....|....*..
gi 1039790226 1178 RWDAPWGCGDNPPRVPADVPADAPAQP 1204
Cdd:PTZ00436   322 KAAAPPAKAATPPAKAAAPPAKAAAAP 348
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1026-1206 3.18e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.16  E-value: 3.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1026 RERDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPPGPVlrlkqiiplqtRPPAPTGCAPPPRSPADTRL-- 1103
Cdd:PHA03307   790 VRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGSESSGPA-----------RPPGAAARPPPARSSESSKSkp 858

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1104 PAFLSLRFLKAPERGPSPPRPgklfafsaREPSANGAPGGGARAHRSAGDEPAAAEPEPRPEDagSASPPAGcwrwDAPW 1183
Cdd:PHA03307   859 AAAGGRARGKNGRRRPRPPEP--------RARPGAAAPPKAAAAAPPAGAPAPRPRPAPRVKL--GPMPPGG----PDPR 924

                          170       180
                   ....*....|....*....|...
gi 1039790226 1184 GCGDNPPRVPADVPadAPAQPAC 1206
Cdd:PHA03307   925 GGFRRVPPGDLHTP--APSAAAL 945
dnaA PRK14086
chromosomal replication initiator protein DnaA;
1030-1175 4.15e-04

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 44.43  E-value: 4.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1030 TGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALlPPGPVLRLKQIIPLQTRPPAP-TGCAPPPRSPADTRLPAFLS 1108
Cdd:PRK14086   122 GGPRADDRPPGLPRQDQLPTARPAYPAYQQRPEPGAW-PRAADDYGWQQQRLGFPPRAPyASPASYAPEQERDREPYDAG 200

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039790226 1109 LRFLKAPERGPSPPRPGKLFAFSAREPSANGAPGGGARaHRSAGDEPAAAEPEPRPEDAGSASPPAG 1175
Cdd:PRK14086   201 RPEYDQRRRDYDHPRPDWDRPRRDRTDRPEPPPGAGHV-HRGGPGPPERDDAPVVPIRPSAPGPLAA 266
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1027-1209 4.16e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 4.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1027 ERDTGGREEARAE--APGPDPVAERGAAKAKGSERPRRPGALLP----PGPVLRLKQII---PLQTRPPA-PTGCAPPPR 1096
Cdd:PHA03247   239 ERRVVISHPLRGDiaAPAPPPVVGEGADRAPETARGATGPPPPPeaaaPNGAAAPPDGVwgaALAGAPLAlPAPPDPPPP 318

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1097 SPAD----------------------TRLPAFL------------SLRFLKAPERGP---SPPRPGKLFAFSAREPSANG 1139
Cdd:PHA03247   319 APAGdaeeeddedgamevvsplprprQHYPLGFpkrrrptwtppsSLEDLSAGRHHPkraSLPTRKRRSARHAATPFARG 398

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1140 ApgGGARAHRSAGDEPAAAePEPRPEDAGSASPPAGCWRWDAPWGCGDNPPRVPADVPADAPAQPACWPT 1209
Cdd:PHA03247   399 P--GGDDQTRPAAPVPASV-PTPAPTPVPASAPPPPATPLPSAEPGSDDGPAPPPERQPPAPATEPAPDD 465
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1019-1208 4.24e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.78  E-value: 4.24e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1019 HAEQQARRERDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLPP-------GPVLRLKQIIPLQTRPPAPTGC 1091
Cdd:PHA03307    77 TEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPpspapdlSEMLRPVGSPGPPPAASPPAAG 156

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1092 APPPRSPADTRLPAFLSLRFLKAPERGPSPPRPGKLFAFSarePSANGAPGGGARAHRSAGDepAAAEPEPRPEDAGSAS 1171
Cdd:PHA03307   157 ASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPS---TPPAAASPRPPRRSSPISA--SASSPAPAPGRSAADD 231

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1039790226 1172 PPAGCWRWDAPWGCG-DNPPRVPADVPADAPAQPACWP 1208
Cdd:PHA03307   232 AGASSSDSSSSESSGcGWGPENECPLPRPAPITLPTRI 269
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1039-1212 6.80e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.01  E-value: 6.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1039 EAPGPDPVAER-GAAKAKGSERPRRPGALLPPG--------PVLRLKQIIPLQTRPPAPTGCAPPPRSPADTRLPaflsl 1109
Cdd:PHA03307   124 ASPPPSPAPDLsEMLRPVGSPGPPPAASPPAAGaspaavasDAASSRQAALPLSSPEETARAPSSPPAEPPPSTP----- 198

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1110 rflkAPERGPSPPRPGKLFAFSAREPSANGAPGGGARAHRSA-----------GDEPAAAEPEPRPEDAGSASPPAGCWR 1178
Cdd:PHA03307   199 ----PAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSsdssssessgcGWGPENECPLPRPAPITLPTRIWEASG 274

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1039790226 1179 W-----DAPWGCGDNPPRVPADVPA-DAPAQPACWPTARH 1212
Cdd:PHA03307   275 WngpssRPGPASSSSSPRERSPSPSpSSPGSGPAPSSPRA 314
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 1020-1181 8.47e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.82  E-value: 8.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1020 AEQQARRERDTGGREEARAEAPGPDPVAergAAKAKGSERPRRPGALLPPGPVlrlkqiiplqTRPPAPTGCAPPPRSPA 1099
Cdd:PRK07764   378 LERLERRLGVAGGAGAPAAAAPSAAAAA---PAAAPAPAAAAPAAAAAPAPAA----------APQPAPAPAPAPAPPSP 444

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1100 DTRLPAflslrflkapERGPSPPRPGKLFAFSAREPSANGAPGGGARAHRSAGDEPAAAEPEPRPEDAGSASPPAGCWR- 1178
Cdd:PRK07764   445 AGNAPA----------GGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATLRe 514


                   ....
gi 1039790226 1179 -WDA 1181
Cdd:PRK07764   515 rWPE 518
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1038-1211 9.58e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 9.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1038 AEAPGPDPvaerGAAKAKGSERPRRPG----ALLPPGPV------LRLKQIIPLQTRPPAPTGCAPPPRSPAdtrLPAFL 1107
Cdd:PHA03247  2491 AAGAAPDP----GGGGPPDPDAPPAPSrlapAILPDEPVgepvhpRMLTWIRGLEELASDDAGDPPPPLPPA---APPAA 2563

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1108 SLRFLKAPERGPSPPRPgklfAFSARE--PSANGAPGGGARAHRSAGDEPAAAEPEPRPEDAGSASPPAGCWRWDA-PWG 1184
Cdd:PHA03247  2564 PDRSVPPPRPAPRPSEP----AVTSRArrPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAAnEPD 2639

                          170       180
                   ....*....|....*....|....*..
gi 1039790226 1185 CGDNPPRVPADVPADAPAQPACWPTAR 1211
Cdd:PHA03247  2640 PHPPPTVPPPERPRDDPAPGRVSRPRR 2666
PHA03381 PHA03381
tegument protein VP22; Provisional
 1040-1192 1.31e-03

tegument protein VP22; Provisional


Pssm-ID: 177618 [Multi-domain]  Cd Length: 290  Bit Score: 42.31  E-value: 1.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1040 APGPDPVAERGAAKAKGSERPRRPGALLPPGPVlRLKQIIPLQTRPPAPTGCAPP---PRSPADTRLPAFLSLRFLKAPE 1116
Cdd:PHA03381    27 SPDASPARVSFEEPADRARRGAGQARGRSQAER-RFHHYDEARADYPYYTGSSSEderPADPRPSRRPHAQPEASGPGPA 105

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1117 RGPSPPRPGKLFAFSAREPSANGAP----GGGARAHRSAGDEPAAAEPEPRPEDAGSASPPAGCWRW----------DAP 1182
Cdd:PHA03381   106 RGARGPAGSRGRGRRAESPSPRDPPnpkgASAPRGRKSACADSAALLDAPAPAAPKRQKTPAGLARKlhfstaptspTAP 185

                          170
                   ....*....|
gi 1039790226 1183 WgcgdnPPRV 1192
Cdd:PHA03381   186 W-----TPRV 190
PHA03321 PHA03321
tegument protein VP11/12; Provisional
 1028-1212 1.43e-03

tegument protein VP11/12; Provisional


Pssm-ID: 223041 [Multi-domain]  Cd Length: 694  Bit Score: 43.02  E-value: 1.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1028 RDTGGREEARAEAPGPDPVAERGAAKAKGSERPRRPGALLP-PGPVLRLKQIIPL---QTRPPAPTGC-----------A 1092
Cdd:PHA03321   428 RQPPGAPAPRRDNDPPPPPRARPGSTPACARRARAQRARDAgPEYVDPLGALRRLpagAAPPPEPAAApspatyytrmgG 507

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1093 PPPRSPAdtRLPAFLSLRflkaPERGPSPPRPGKLFAFSAREPSANGAPGGGARAHRSAGDEPAAAEPE----------- 1161
Cdd:PHA03321   508 GPPRLPP--RNRATETLR----PDWGPPAAAPPEQMEDPYLEPDDDRFDRRDGAAAAATSHPREAPAPDddpiyegvsds 581

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1162 ------------------PRPEDAGSA----SPPAGCW-RWDAP---WGCGD--NPPRVPADVPADAPAQPA--CWPTAR 1211
Cdd:PHA03321   582 eepvyeeiptprvyqnplPRPMEGAGEppdlDAPTSPWvEEENPiygWGDSPlfSPPPAARFPPPDPALSPEppALPAHR 661


                   .
gi 1039790226 1212 H 1212
Cdd:PHA03321   662 P 662
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1040-1173 1.47e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 1.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1040 APGpDPVAERG---AAKAKGSERPRRPGALLPPGPVLRLKQIIPLQTRPPA--PTGCAPPPRSPADTRLPAFLSLRFLKA 1114
Cdd:PHA03247  2857 APG-GDVRRRPpsrSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPErpPQPQAPPPPQPQPQPPPPPQPQPPPPP 2935

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039790226 1115 PERGPSPPRPgklfafsAREPSANGAPGGGARAHRSAGDEPAAAE------PEPRPEDAGSASPP 1173
Cdd:PHA03247  2936 PPRPQPPLAP-------TTDPAGAGEPSGAVPQPWLGALVPGRVAvprfrvPQPAPSREAPASST 2993
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1081-1207 1.83e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.56  E-value: 1.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1081 LQTRPPAPTGCAPPPRS---PADTRLPAFLSLRFL-KAPERGPSPPRPGKLFAFSAREPSANGAPGGGARA------HRS 1150
Cdd:PRK12323   361 LAFRPGQSGGGAGPATAaaaPVAQPAPAAAAPAAAaPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEalaaarQAS 440

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039790226 1151 AGDEPAAAEPEPRPED--AGSASPPAGCWRWDAPWGCGDNPPRVPADVPADAPAQPACW 1207
Cdd:PRK12323   441 ARGPGGAPAPAPAPAAapAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPW 499
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1028-1207 1.92e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.47  E-value: 1.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1028 RDTGGREEARAEAPGPDPVAERGAAkAKGSERPRRPGALLPPGPVLRLKQIIPLQTRP-----PAPTGCAPPPRSPADTR 1102
Cdd:PHA03307   759 SNPSLVPAKLAEALALLEPAEPQRG-AGSSPPVRAEAAFRRPGRLRRSGPAADAASRTaskrkSRSHTPDGGSESSGPAR 837

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1103 lpaflslrflkAPERGPSPPRPGKLFAFSAREPSANGAPGGGARAHRSAGDEPAAAEPEPRPEDAGSASPPAGcwrwdaP 1182
Cdd:PHA03307   838 -----------PPGAAARPPPARSSESSKSKPAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKAAAAAPPAG------A 900

                          170       180
                   ....*....|....*....|....*..
gi 1039790226 1183 WGCGDNPPRVPADV--PADAPAQPACW 1207
Cdd:PHA03307   901 PAPRPRPAPRVKLGpmPPGGPDPRGGF 927
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 1045-1212 2.49e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.01  E-value: 2.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1045 PVAERGAAKAKGSERPRRPGALLP-PGPvlrlkqiiplqtRPPAPTGCAPPPRSPADTRLPAflslrflkAPERGPSPPR 1123
Cdd:PRK14951   366 PAAAAEAAAPAEKKTPARPEAAAPaAAP------------VAQAAAAPAPAAAPAAAASAPA--------APPAAAPPAP 425

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1124 PgklfafSAREPSANGAPG-GGARAHRSAGDEPAAAEPEPRPEDAGSASPPAgcwrwdapwgcgdnpPRVPADVPADAPA 1202
Cdd:PRK14951   426 V------AAPAAAAPAAAPaAAPAAVALAPAPPAQAAPETVAIPVRVAPEPA---------------VASAAPAPAAAPA 484

                          170
                   ....*....|
gi 1039790226 1203 QPACWPTARH 1212
Cdd:PRK14951   485 AARLTPTEEG 494
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 1050-1180 2.62e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 41.97  E-value: 2.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1050 GAAKAKGSERPRRPGALLPPGPvlrlKQIIPLQTRPPA---PTGCAPPPRSPADTRLPaflSLRFLKAPergPSPPRPGK 1126
Cdd:PRK14959   379 SAPSGSAAEGPASGGAATIPTP----GTQGPQGTAPAAgmtPSSAAPATPAPSAAPSP---RVPWDDAP---PAPPRSGI 448

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039790226 1127 LFAFSAREPSANGAPGGGARAHRSAGDEPAAAEPeprpeDAGSASPPAGCWRWD 1180
Cdd:PRK14959   449 PPRPAPRMPEASPVPGAPDSVASASDAPPTLGDP-----SDTAEHTPSGPRTWD 497
KLF14_N cd21576
N-terminal domain of Kruppel-like factor 14; Kruppel-like factor 14 (KLF14; also known as ...
 1043-1212 3.58e-03

N-terminal domain of Kruppel-like factor 14; Kruppel-like factor 14 (KLF14; also known as Krueppel-like factor 14 or basic transcription element-binding protein 5/BTEB5) is a protein that in humans is encoded by the KLF14 gene. KLF14 regulates the transcription of various genes, including TGFbetaRII (the type II receptor for TGFbeta). KLF14 is expressed in many tissues, lacks introns, and is subject to parent-specific expression. It also appears to be a master regulator of gene expression in adipose tissue. KLF14 is associated with coronary artery disease, hypercholesterolemia, and type 2 diabetes. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF14 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF14.


Pssm-ID: 409238 [Multi-domain]  Cd Length: 195  Bit Score: 40.19  E-value: 3.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1043 PDPVAERGAAKAKGSERPRRPgALLPPGPvlRLKQIIPLQTRPPAPtgcaPPPRSPADTRLPAFLSLRFLK--APERGPS 1120
Cdd:cd21576     29 PDPEGAGGAAGSEVGAAPPES-ALPGPGP--PGPAWVPPLLQVPAP----SPGAGGAAPHLLAASVLADLRggAGEGSRE 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1121 PPRPGKLFAFSAREPSANGAPGGGARAHRSAGDEpAAAEPEPRPEDAGSASPPAGCWRWDAPWGCGDNPPRV-PADVPAD 1199
Cdd:cd21576    102 DSGEAPRASSGSSDPARGSSPTLGSEPAPASGED-AVSGPESSFGAPAIPSAPAAPGAPAVSGEVPGGAPGAgPAPAAGP 180

                          170
                   ....*....|....
gi 1039790226 1200 APAQPACWPTA-RH 1212
Cdd:cd21576    181 APRRRPVTPAAkRH 194
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 1020-1175 6.03e-03

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 40.82  E-value: 6.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1020 AEQQARRERDTGGREEARAEAPGPDPVAERGAAKAKGSERP-RRPGALLPPGPVLRLKQIIPLQTRPPAPTG-----CAP 1093
Cdd:COG5180    208 DEAQEEPPDLTGGADHPRPEAASSPKVDPPSTSEARSRPATvDAQPEMRPPADAKERRRAAIGDTPAAEPPGlpvleAGS 287

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039790226 1094 PPRS---PADTRLPAFLSLRFLKAPERGPSPPRPGKLFAFSAREPSANGAPgggarahrsAGDEPAAAEPEPRPedagSA 1170
Cdd:COG5180    288 EPQSdapEAETARPIDVKGVASAPPATRPVRPPGGARDPGTPRPGQPTERP---------AGVPEAASDAGQPP----SA 354


                   ....*
gi 1039790226 1171 SPPAG 1175
Cdd:COG5180    355 YPPAE 359
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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