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Conserved domains on  [gi|1039781485|ref|XP_017168011|]
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chromaffin granule amine transporter isoform X2 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 127-435 2.89e-162

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17384:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 373  Bit Score: 463.58  E-value: 2.89e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 127 EFLEEeNVRIGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSV 206
Cdd:cd17384    25 DYLNE-NVRVGLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSV 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 207 AGLGMLASVYTDNYERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQFCILWPSKVSPESAM 286
Cdd:cd17384   104 AGMGMLASLYPDDKERGKAMGIALGGLALGVLVGPPFGGVMYEFVGKSAPFLILAFLALLDGALQLFILQPSVKSEESEE 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 287 GTPLLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCS 366
Cdd:cd17384   184 GTPWKTLLKDPYILIAAGAICFSNSGIAILEPCLPIWMMETMCPPKWQLGTAFLPDSIGYLIGTNLFGPLAHKIGRWLCS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 367 LVGMVAVGISLLCVPLAHNIFGLIGPNAGLG----------------------------------------FAIGPSTGG 406
Cdd:cd17384   264 LLGMLLVGISLILIPLAKNIYGLIIPHFGLGlgigmvdssmmpllaylvdlrhssvygsvyaiadvafclaFALGPSLGG 343

                         330       340
                  ....*....|....*....|....*....
gi 1039781485 407 VIVPVIGFPWLMVIIGTINIIYAPLCCFL 435
Cdd:cd17384   344 AIVKSIGFPWLMRIIGIINILYAPLLFFL 372
 
Name Accession Description Interval E-value
MFS_SLC18A1_2_VAT1_2 cd17384
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...
 127-435 2.89e-162

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340942 [Multi-domain]  Cd Length: 373  Bit Score: 463.58  E-value: 2.89e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 127 EFLEEeNVRIGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSV 206
Cdd:cd17384    25 DYLNE-NVRVGLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSV 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 207 AGLGMLASVYTDNYERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQFCILWPSKVSPESAM 286
Cdd:cd17384   104 AGMGMLASLYPDDKERGKAMGIALGGLALGVLVGPPFGGVMYEFVGKSAPFLILAFLALLDGALQLFILQPSVKSEESEE 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 287 GTPLLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCS 366
Cdd:cd17384   184 GTPWKTLLKDPYILIAAGAICFSNSGIAILEPCLPIWMMETMCPPKWQLGTAFLPDSIGYLIGTNLFGPLAHKIGRWLCS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 367 LVGMVAVGISLLCVPLAHNIFGLIGPNAGLG----------------------------------------FAIGPSTGG 406
Cdd:cd17384   264 LLGMLLVGISLILIPLAKNIYGLIIPHFGLGlgigmvdssmmpllaylvdlrhssvygsvyaiadvafclaFALGPSLGG 343

                         330       340
                  ....*....|....*....|....*....
gi 1039781485 407 VIVPVIGFPWLMVIIGTINIIYAPLCCFL 435
Cdd:cd17384   344 AIVKSIGFPWLMRIIGIINILYAPLLFFL 372
2_A_01_02 TIGR00880
Multidrug resistance protein;
137-278 4.86e-30

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 113.90  E-value: 4.86e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 137 GILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASVY 216
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039781485 217 TDNyERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQFCILWPS 278
Cdd:TIGR00880  81 PPE-ERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
136-401 2.05e-24

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 103.90  E-value: 2.05e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 136 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 215
Cdd:COG2814    47 AGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADL 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 216 YTDNyERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQFCILWPSKVSPESAMGTPLLTLLK 295
Cdd:COG2814   127 VPPE-RRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLR 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 296 DPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGI 375
Cdd:COG2814   206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285

                         250       260
                  ....*....|....*....|....*.
gi 1039781485 376 SLLCVPLAHNIFGLIGPNAGLGFAIG 401
Cdd:COG2814   286 GLLLLALAGSLWLLLLALFLLGFGFG 311
MFS_1 pfam07690
Major Facilitator Superfamily;
136-409 7.40e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 72.45  E-value: 7.40e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 136 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 215
Cdd:pfam07690  34 IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADW 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 216 YTDNyERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLdGALQFCILWPSKVSPESAM--------G 287
Cdd:pfam07690 114 FPPE-ERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLL-AAVLLLLPRPPPESKRPKPaeearlslI 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 288 TPLLTLLKDPYILVAAGsICLANMGVAILEPTLPIWmMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSL 367
Cdd:pfam07690 192 VAWKALLRDPVLWLLLA-LLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL 269

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1039781485 368 VGMVAVGISLLCVPLAHNIFGLIGPNAGL---GFAIGPSTGGVIV 409
Cdd:pfam07690 270 LALLLLILAALGLLLLSLTLSSLWLLLALlllGFGFGLVFPALNA 314
emrD PRK11652
multidrug transporter EmrD;
153-200 1.46e-03

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 40.66  E-value: 1.46e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1039781485 153 FVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIG 200
Cdd:PRK11652   62 FYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLG 109
 
Name Accession Description Interval E-value
MFS_SLC18A1_2_VAT1_2 cd17384
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...
 127-435 2.89e-162

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340942 [Multi-domain]  Cd Length: 373  Bit Score: 463.58  E-value: 2.89e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 127 EFLEEeNVRIGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSV 206
Cdd:cd17384    25 DYLNE-NVRVGLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSV 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 207 AGLGMLASVYTDNYERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQFCILWPSKVSPESAM 286
Cdd:cd17384   104 AGMGMLASLYPDDKERGKAMGIALGGLALGVLVGPPFGGVMYEFVGKSAPFLILAFLALLDGALQLFILQPSVKSEESEE 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 287 GTPLLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCS 366
Cdd:cd17384   184 GTPWKTLLKDPYILIAAGAICFSNSGIAILEPCLPIWMMETMCPPKWQLGTAFLPDSIGYLIGTNLFGPLAHKIGRWLCS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 367 LVGMVAVGISLLCVPLAHNIFGLIGPNAGLG----------------------------------------FAIGPSTGG 406
Cdd:cd17384   264 LLGMLLVGISLILIPLAKNIYGLIIPHFGLGlgigmvdssmmpllaylvdlrhssvygsvyaiadvafclaFALGPSLGG 343

                         330       340
                  ....*....|....*....|....*....
gi 1039781485 407 VIVPVIGFPWLMVIIGTINIIYAPLCCFL 435
Cdd:cd17384   344 AIVKSIGFPWLMRIIGIINILYAPLLFFL 372
MFS_SLC18A3_VAChT cd17383
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ...
 131-435 1.36e-82

Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340941 [Multi-domain]  Cd Length: 378  Bit Score: 260.32  E-value: 1.36e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 131 EENVRIGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLG 210
Cdd:cd17383    27 NEDIAIGVLFASKAIVQLLVNPFSGTLIDRVGYDIPMMIGLTVMFLSTAVFAFGESYAVLFFARSLQGVGSAFADTAGLA 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 211 MLASVYTDNYERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQFCILWP----SKVSPESAM 286
Cdd:cd17383   107 MIADRFTEEAERSKALGIALAFISFGCLVAPPFGGILYEFAGKEVPFLILAFVCLLDGLLLLLVMKPvrreTRANMPEPV 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 287 GTPLLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGR--WL 364
Cdd:cd17383   187 GTPIHRLLMDPYIAVCAGALTMANVSLAFLEPTIANWMKDTMNASEWQMGLVWLPAFFPHVLGVYLTVKLAAKYPHyqWL 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 365 CSLVGMVAVGISLLCVPLAHNIFGLIGPNAGLGF----------------------------------------AIGPST 404
Cdd:cd17383   267 MAAVGLAIEGASCFIVPFCTNFGVLIIPLCGICFgialvdtallptlgflvdvrhvsvygsvyaiadisyslayALGPIV 346

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1039781485 405 GGVIVPVIGFPWLMVIIGTINIIYAPLCCFL 435
Cdd:cd17383   347 AGQIVHSIGFTQLNIGIGLANLLYAPVLLLL 377
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 133-431 4.92e-48

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 169.68  E-value: 4.92e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 133 NVRIGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGML 212
Cdd:cd17325    30 VAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALI 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 213 ASVYTDNyERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQFCILWPSKVSPESA------M 286
Cdd:cd17325   110 ADIAPPE-ERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRavsaarL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 287 GTPLLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCS 366
Cdd:cd17325   189 RSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLI 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 367 LVGMVAVGISLLCVPLAHNIFGLIGPNA-------------------------------------GLGFAIGPSTGGVIV 409
Cdd:cd17325   269 LIGLLLSAVALLLLPLATSFWLLLLLLAllglglglvfpatlalladivppegrgtamglfntafSLGMVLGPLLGGFLY 348

                         330       340
                  ....*....|....*....|..
gi 1039781485 410 PVIGFPWLMVIIGTINIIYAPL 431
Cdd:cd17325   349 DAFGFATPFLAAAALLLLAAVL 370
2_A_01_02 TIGR00880
Multidrug resistance protein;
137-278 4.86e-30

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 113.90  E-value: 4.86e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 137 GILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASVY 216
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039781485 217 TDNyERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQFCILWPS 278
Cdd:TIGR00880  81 PPE-ERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
136-401 2.05e-24

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 103.90  E-value: 2.05e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 136 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 215
Cdd:COG2814    47 AGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADL 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 216 YTDNyERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQFCILWPSKVSPESAMGTPLLTLLK 295
Cdd:COG2814   127 VPPE-RRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLR 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 296 DPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGI 375
Cdd:COG2814   206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285

                         250       260
                  ....*....|....*....|....*.
gi 1039781485 376 SLLCVPLAHNIFGLIGPNAGLGFAIG 401
Cdd:COG2814   286 GLLLLALAGSLWLLLLALFLLGFGFG 311
MFS_1 pfam07690
Major Facilitator Superfamily;
136-409 7.40e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 72.45  E-value: 7.40e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 136 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 215
Cdd:pfam07690  34 IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADW 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 216 YTDNyERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLdGALQFCILWPSKVSPESAM--------G 287
Cdd:pfam07690 114 FPPE-ERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLL-AAVLLLLPRPPPESKRPKPaeearlslI 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 288 TPLLTLLKDPYILVAAGsICLANMGVAILEPTLPIWmMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSL 367
Cdd:pfam07690 192 VAWKALLRDPVLWLLLA-LLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL 269

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1039781485 368 VGMVAVGISLLCVPLAHNIFGLIGPNAGL---GFAIGPSTGGVIV 409
Cdd:pfam07690 270 LALLLLILAALGLLLLSLTLSSLWLLLALlllGFGFGLVFPALNA 314
MFS_SLC18B1 cd17385
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...
 136-427 9.12e-14

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340943 [Multi-domain]  Cd Length: 390  Bit Score: 72.64  E-value: 9.12e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 136 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAF-----SGT--YALLFVARTLQGIGSSFSSVAG 208
Cdd:cd17385    36 IGLVFGCFALVIFLTSPIFGKYLVKIGAKFMFVAGMFVSGGCTILFGFldrvpDGTvfIALCFLVRIVEAVGFAAFITAS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 209 LGMLASVYTDNYerGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQFCILwPSKVSPESAMGT 288
Cdd:cd17385   116 FAIIAKEFPNNI--ATVLGTLETFSGLGLMLGPPLGGFLYQAGGYELPFLVLGCLLLLTVPLNMFIL-PRYDDDPSPKSG 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 289 PLLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPeWQLGLAFLPASVAYLIGTNLFGVLANKMG-RWLCSL 367
Cdd:cd17385   193 SMLKLLKIPSVLLLCLSIVSGSVSLGFLDPTLSPHLRQFKLSP-GQVGLMFLILAGSYAISAPLWGWLSDKKKiPKWLMV 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 368 VGMVAVGISLLCV---PLAH-------NIFGLIGPNAGLGFA-------------------------------------- 399
Cdd:cd17385   272 IGSIITGVGFLLLgpaPLLPikselwmVIIGLVLLGLSLGAAlvptfpellncareygfpdnlstyglvsglfnaafslg 351

                         330       340       350
                  ....*....|....*....|....*....|
gi 1039781485 400 --IGPSTGGVIVPVIGFPWLMVIIGTINII 427
Cdd:cd17385   352 afIGPTLGGFLLERLGFEWAATIQAGLAFV 381
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 136-427 3.72e-13

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 70.70  E-value: 3.72e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 136 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASv 215
Cdd:cd17489    33 AGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVAD- 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 216 YTDNYERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALldGALQFCILWP---SKVSPESAMGTPLLT 292
Cdd:cd17489   112 IIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLAL--LALLLVFLVKdppPVAAEEAEAGTRAFR 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 293 LLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTmcsPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVA 372
Cdd:cd17489   190 RLVEKKVLPPALILFLASIAYGAISTFLPLYAAER---GISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLL 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 373 VGISLLCVPLAHNI-------------FGLIGPNAG------------------------LGFAIGPSTGGVIVPVIGFP 415
Cdd:cd17489   267 LALGLLLLSFAGSPwmlllaavlyglgFGLLFPALQalavdlvpphrrgaangtffiffdLGIGLGGLLLGLVAELFGYR 346

                         330
                  ....*....|..
gi 1039781485 416 WLMVIIGTINII 427
Cdd:cd17489   347 AMFLLAAVVVLL 358
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 126-401 8.27e-12

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 66.68  E-value: 8.27e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 126 IEFLEEENVRIGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSS 205
Cdd:cd06174    23 LQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLID 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 206 VAGLGMLASVYTDNyERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQFCILWP-------- 277
Cdd:cd06174   103 PAVLALIADLFPER-ERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVpdppesar 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 278 --SKVSPESAMGTPLLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGV 355
Cdd:cd06174   182 akNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGL 261

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1039781485 356 LANK-MGRWLCSLVGMVAVGISLLCVPLAHNIFGLIGPNAGLGFAIG 401
Cdd:cd06174   262 LSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLG 308
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 136-401 8.47e-12

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 66.42  E-value: 8.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 136 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 215
Cdd:cd17324    36 AGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 216 YTDNyERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLalldGALQFCILW------PSKVSPESAMGTP 289
Cdd:cd17324   116 VPPE-KRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVL----ALLAALLLWrllpslPPKKPGSLGLLSS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 290 LLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVG 369
Cdd:cd17324   191 LLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIAL 270

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1039781485 370 MVAVGISLLCVPLAHNIFGLIGPNAGLGFAIG 401
Cdd:cd17324   271 LLLAAALLLLTLLGPSPLLLLVGLVLWGLGFF 302
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 136-431 8.53e-11

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 63.40  E-value: 8.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 136 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 215
Cdd:cd17329    37 VGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADV 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 216 YTD-NYERGRAMGIALGGLALGllvgapFGSVMYEFVGKSSPFLILAFLALLDGALQFCILW-------PSKVSPESAMG 287
Cdd:cd17329   117 TTPeNRTRAFSLLYWAINLGVA------IGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFllpetrpKRRAAEKTEIL 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 288 TPLLTLLKD-PYILVAAGSICLAnMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCS 366
Cdd:cd17329   191 RGYKIVLRDrAFLLFLLASFLIS-LIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKIL 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 367 LVGMVAVGISLLCVPLAHNIFGLIG-------------PNA------------------------GLGFAIGPSTGGVIV 409
Cdd:cd17329   270 MIGILLFAIGFAVLAFANTLAVLILamivltlgemlvfPAVqtlvaalappdkrgsymgfyalawGLGRAIGPLVGGLLL 349

                         330       340
                  ....*....|....*....|..
gi 1039781485 410 PVIGFPWLMVIIGTINIIYAPL 431
Cdd:cd17329   350 DLLGPGLPWLILAALGLIAAAL 371
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
133-405 2.39e-10

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 61.81  E-value: 2.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 133 NVRIGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGML 212
Cdd:COG2271    44 AAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLI 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 213 ASVYTDNyERGRAMGIALGGLALGLLVGAPFGSVMYEFVGksspflilaflalldgaLQFCILWPskvspesAMGTPLLT 292
Cdd:COG2271   124 AEWFPPK-ERGRALGIFNAGGPLGGALAPPLLGWLLAAFG-----------------WRAAFLIL-------GLPGLLLA 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 293 LLKdpyILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGR--WLCSLVGM 370
Cdd:COG2271   179 LLR---FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGL 255

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1039781485 371 VAVGISLLCVPLAHNIFGLIGPNAGLGFAIGPSTG 405
Cdd:COG2271   256 LLAALALLLLALLPSPALAIALLFLAGFGLGGAFG 290
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 152-405 1.21e-09

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 59.88  E-value: 1.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 152 PFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASVYTDNyERGRAMGIALG 231
Cdd:cd17321    49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGE-RRGRALGLWGA 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 232 GLALGLLVGAPFGSVMYEFVGKSSpflilaflalldgalqfcILWpskvspesaMGTP--LLTLLKDPYILVAAGSICLA 309
Cdd:cd17321   128 VVGIGAALGPLLGGLLLELFGWRW------------------IFL---------INVPigLVALLLARTFSGAVLAAFLL 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 310 NMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGISLLCVPLAHN---- 385
Cdd:cd17321   181 GAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGAdssv 260

                         250       260
                  ....*....|....*....|...
gi 1039781485 386 ---IFGLIGPNAGLGFAIGPSTG 405
Cdd:cd17321   261 wllLPGLVLLGLGLGLFATPLTN 283
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 136-387 1.36e-09

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 59.51  E-value: 1.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 136 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAglGMLASV 215
Cdd:cd17330    36 VGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVA--QAYIAD 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 216 YTDNYERGRAMGIALGGLALGLLVGAPFGSVMYEFVGksspflilaflalldgalqfcILWPSKVSPESAMGTPLLTLLK 295
Cdd:cd17330   114 ITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYG---------------------YALPFLVAAALALLNLVLVLFF 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 296 DPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLI-GTNLFGVLANKMGRWLCSLVGMVAVG 374
Cdd:cd17330   173 LPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILaQLLLIPRLAKRLGERKLLRLGLLLAI 252

                         250
                  ....*....|...
gi 1039781485 375 ISLLCVPLAHNIF 387
Cdd:cd17330   253 IGLLLLPFASSVP 265
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
136-401 7.17e-09

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 57.60  E-value: 7.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 136 IGILFASKALMQLLVNPFVGPLTNR-------------IGYhIPMFVGFMIMFLSTlMFAFSGTYALLFVARTLQGIGSS 202
Cdd:COG2211    48 VGLILLVARLWDAITDPLIGALSDRtrtrwgrrrpwilIGA-IPLALSFVLLFTAP-DLSPTGKLIYALVTYLLLGLAYT 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 203 FSSVAGLGMLASVYTDNYERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQFCILWPSKVSP 282
Cdd:COG2211   126 LVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTK 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 283 ESAMGTP--------LLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFG 354
Cdd:COG2211   206 ERPVPEEekvslkesLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWP 285

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1039781485 355 VLANKMGRWLCSLVGMVAVGISLLCVPLA--HNIFGLIGPNAGLGFAIG 401
Cdd:COG2211   286 RLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLG 334
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
133-401 2.99e-08

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 55.63  E-value: 2.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 133 NVRIGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGML 212
Cdd:COG0738    42 DAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYV 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 213 ASVYTDNyeRGRAMgialgglaLGLLVGAPFGSVMYEFVG----KSSPFLILAFLALLDGALQFCIL----------WPS 278
Cdd:COG0738   122 AALGPET--AASRL--------NLLHAFFSLGALLGPLLGglliLLGLSLSWHLPYLILAVLLLLLAllflrsklpeIEE 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 279 KVSPESAMGTPLLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLAN 358
Cdd:COG0738   192 EEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLK 271

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1039781485 359 KMGRW----LCSLVGMVAVGISLLCVPLAHNIFGLIGpnAGLGFAIG 401
Cdd:COG0738   272 RFGPVrllrLSALLAAVGLLLALLAPGPWLALIGLAL--VGLGLSLM 316
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 136-226 2.02e-07

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 52.51  E-value: 2.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 136 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 215
Cdd:COG0477    51 LGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAEL 130

                          90
                  ....*....|.
gi 1039781485 216 YTDNyERGRAM 226
Cdd:COG0477   131 FPAR-ERGRAL 140
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 136-401 2.09e-07

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 52.96  E-value: 2.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 136 IGILFASKALMQLlvnpFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 215
Cdd:cd17320    40 LSAYLLGFALGQL----LYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 216 YTDNyERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALqFCILWPSKVSPE------SAMGTP 289
Cdd:cd17320   116 YSGA-ELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLL-VLLFLPETLPEEkrkpllSSLLRA 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 290 LLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMG-----RWL 364
Cdd:cd17320   194 YKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGprrllRLG 273

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1039781485 365 CSLVGMVAVGISLLCVPLAHNIFGLIGPNAGLGFAIG 401
Cdd:cd17320   274 LLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFG 310
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 136-418 3.06e-07

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 52.22  E-value: 3.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 136 IGILFASKALMQLLVNPFVGPLTNRIGYHIP-MFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFsSVAGLGMLAS 214
Cdd:cd17490    33 IGIILGAYGISQMLLRIPLGILSDRIGKRKLfIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAAT-WVSFTVLYAS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 215 vYTDNYERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLalldGALQFCILWPSKVSPESAMGTP----- 289
Cdd:cd17490   112 -YFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALA----GVLGFILSLFIKEERREKKPVLtelke 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 290 LLTLLKDPYILVAAG-SICLANMGVAILEPTLPIWMMQTMCSpEWQLGLAFLPASVAYLIGTNLFGVLA-NKMGRWLCSL 367
Cdd:cd17490   187 LLSVLKDKKLLFFSLlAILQQMITFSTTFGFTPLIAKQLGAS-SFQLGLLSIIYLLPNALASLLSGTLFyKKLGERNTII 265

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1039781485 368 VGMVAVGISLLCVPLAHNIFGLIGPNAGLGFAIGpstggvivpvIGFPWLM 418
Cdd:cd17490   266 IGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTG----------ILFPLLM 306
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 136-403 5.15e-07

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 51.85  E-value: 5.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 136 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAF-----SGTYALLFVARTLQGIGSSFSSVAGLG 210
Cdd:cd06173    36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALlallgSLSLWLLLVLAFLLGIASAFFGPARQA 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 211 MLASVyTDNYERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQFCILWPSKVSPESAMGTP- 289
Cdd:cd06173   116 LLPEL-VPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLl 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 290 ------LLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRW 363
Cdd:cd06173   195 rdlregLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRG 274

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1039781485 364 LCSLVGMVAVGISLLCVPLAHNIFGLIGPNAGLGFAIGPS 403
Cdd:cd06173   275 RLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLF 314
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
136-226 7.55e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 51.13  E-value: 7.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 136 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 215
Cdd:COG2814   245 AGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324

                          90
                  ....*....|.
gi 1039781485 216 YTDNyERGRAM 226
Cdd:COG2814   325 APPE-ARGRAS 334
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
136-429 1.04e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 50.65  E-value: 1.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 136 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 215
Cdd:COG2223    42 LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKW 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 216 YTDNyERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLAlldGALQFCILWPSKVSPESAMGTP------ 289
Cdd:COG2223   122 FPPD-RRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILL---LVVAVLAWLFLRDPPAGAAAAAkaslrd 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 290 LLTLLKDP--------YILVAAGSICLANMGVAILEPTLPIWMMQTmcspewqLGLAFLPASVAyLIGTNLFGVLANKMG 361
Cdd:COG2223   198 QLEALRDPrfwllsllYFGTFGSFIGFSSWLPPYLVDQFGLSAATA-------GLLAALFALLG-ALGRPLGGWLSDRIG 269

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039781485 362 RWLCSLVGMVAVGISLLCVPLA-HNIFGLIGPNAGLGFAIGPSTGGV--IVPVIgFPWLMV--IIGTINIIYA 429
Cdd:COG2223   270 GRRVLLIVFALMALGLLLLALAlGSLWLFLVLFLLLGLALGGGNGAVfaLVPDI-FPTKNAgaVYGLVGAAGG 341
MFS_1 pfam07690
Major Facilitator Superfamily;
305-446 2.50e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 49.34  E-value: 2.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 305 SICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGISLLCVPLAH 384
Cdd:pfam07690   4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 385 NIFGLIG-------------PNA------------------------GLGFAIGPSTGGVIVPVIGFPWLMVIIGTINII 427
Cdd:pfam07690  84 SLWLLLVlrvlqglgagalfPAAlaliadwfppeergralglvsagfGLGAALGPLLGGLLASLFGWRAAFLILAILSLL 163

                         170
                  ....*....|....*....
gi 1039781485 428 YAPLCCFLQNPPAKEEELA 446
Cdd:pfam07690 164 AAVLLLLPRPPPESKRPKP 182
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 146-401 2.69e-06

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 49.47  E-value: 2.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 146 MQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVART-LQGIGSSFSSVAGLGMLASvYTDNYeRGR 224
Cdd:cd17352    50 VSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYGvLGGLGLGLIYSPAIVIVGQ-YFEKK-RGL 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 225 AMGIALGGLALGLLVGAPFGSVMYEFVGksspflilaflalldgaLQFCILWPSKVSPESAMGTPLLTLLKDPYILVAAG 304
Cdd:cd17352   128 ATGIAVAGSGVGTFVFPPLLRYLLDNYG-----------------WRGALLILGGLCLNLCVCGLLLRLLKDPTFVLLAL 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 305 SICLANMGVAILEPTLPIWMMqTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANK--MGRWLCSLVGMVAVGISLLCVPL 382
Cdd:cd17352   191 GVSFAMLGFFVPFVYLPSYAK-SLGIDESDAAFLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLILGLSLLAFPL 269

                         250
                  ....*....|....*....
gi 1039781485 383 AHNIFGLIGPNAGLGFAIG 401
Cdd:cd17352   270 ATTYVGLIVFSVLFGFCSG 288
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 136-401 4.40e-06

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 48.72  E-value: 4.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 136 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 215
Cdd:cd17474    36 VGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 216 YTDNyERGRAMGIALGGLAlgllvgapFGSVMYEFVG----KSSPFLILAFLALLDGALQFCILWPSKVSPESAMGTPLL 291
Cdd:cd17474   116 FEGG-ERAKAMGLYEAALG--------LGIAVGPLLGgllaAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSAT 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 292 TL------LKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFG-VLANKMGRWL 364
Cdd:cd17474   187 KLrdlkkaLRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARR 266

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1039781485 365 CSLVGMVAVGISLLCVPLAHNIFGLIGPNAGLGFAIG 401
Cdd:cd17474   267 ILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLG 303
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 136-207 1.35e-05

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 47.19  E-value: 1.35e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039781485 136 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSG---TYALLFVARTLQGIGSSFSSVA 207
Cdd:cd17503   216 SGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTpdtSLWLIILPLFIRGLGMGLVFMP 290
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
299-431 6.25e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 44.96  E-value: 6.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 299 ILVAAGSICLANMGVAILEPTLPiWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGISLL 378
Cdd:COG2814    12 LLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 379 CVPLAHNI-------------------------------------FGLIGPNAGLGFAIGPSTGGVIVPVIGFPWLMVII 421
Cdd:COG2814    91 LCALAPSLwlllaarflqglgagalfpaalaliadlvpperrgraLGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVN 170

                         170
                  ....*....|
gi 1039781485 422 GTINIIYAPL 431
Cdd:COG2814   171 AVLALLALLL 180
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 136-226 6.79e-05

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 44.85  E-value: 6.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 136 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 215
Cdd:cd17478    33 AGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQA 112

                          90
                  ....*....|.
gi 1039781485 216 YTDNyeRGRAM 226
Cdd:cd17478   113 AGGR--RGLAM 121
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
136-215 1.99e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 43.74  E-value: 1.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 136 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGT--YALLFVARTLQGIGSSFSSVAGLGMLA 213
Cdd:COG2211   266 VGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPgnLWLLLVLAALAGIGLGAILVLPWAMLA 345


                  ..
gi 1039781485 214 SV 215
Cdd:COG2211   346 DV 347
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 136-226 2.07e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 43.32  E-value: 2.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 136 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 215
Cdd:cd17477    33 IGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNAL 112

                          90
                  ....*....|.
gi 1039781485 216 yTDNYERGRAM 226
Cdd:cd17477   113 -ATNENRGRVL 122
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 134-226 3.77e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 42.56  E-value: 3.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 134 VRIGILFASKALMQLLVNPFVGPLTN-RIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGML 212
Cdd:cd17474   234 IIIGLLFAGWSVLLALGSLFVGRLLKkRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLV 313

                          90
                  ....*....|....
gi 1039781485 213 ASVyTDNYERGRAM 226
Cdd:cd17474   314 TEL-APEEERGTAS 326
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 144-215 4.74e-04

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 42.59  E-value: 4.74e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039781485 144 ALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAF--SGTYALLFVARTLQGIGSSFSSVAGLGMLASV 215
Cdd:cd17332   266 LSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFlpPGNLVLILVLAVLAGIGYGGANLLPWAMLADV 339
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 153-227 8.82e-04

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 41.41  E-value: 8.82e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039781485 153 FVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGI-GSSFSSVAGlGMLASVYTDNyERGRAMG 227
Cdd:cd17323    53 IWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFfGSSPLAIGA-GTIADLFTPE-ERGKAMG 126
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
136-226 1.26e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 41.01  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 136 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 215
Cdd:COG2807    55 AGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRW 134

                          90
                  ....*....|.
gi 1039781485 216 YTDNyeRGRAM 226
Cdd:COG2807   135 FPDR--VGLMT 143
emrD PRK11652
multidrug transporter EmrD;
153-200 1.46e-03

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 40.66  E-value: 1.46e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1039781485 153 FVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIG 200
Cdd:PRK11652   62 FYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLG 109
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 136-226 3.16e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 39.86  E-value: 3.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 136 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 215
Cdd:cd17473   235 IGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSL 314

                          90
                  ....*....|.
gi 1039781485 216 YTDNyERGRAM 226
Cdd:cd17473   315 VPPE-LRGRAM 324
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 135-208 4.37e-03

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 39.16  E-value: 4.37e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039781485 135 RIGILFASKALMQLLVNPFVGPLTNRIGYHiPMFVGFMIMF-LSTLMFAFSGTYALLFVARTLQGIGSSFSSVAG 208
Cdd:cd17388    39 HYGVLLALYALMQFIFAPILGALSDRFGRR-PVLLLSLAGAaLDYLLMAFAPTLWWLYLGRIIAGITGATGAVAA 112
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 136-226 5.25e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 39.09  E-value: 5.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 136 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASV 215
Cdd:cd17473    37 VPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDY 116

                          90
                  ....*....|.
gi 1039781485 216 YTDnYERGRAM 226
Cdd:cd17473   117 FEG-EERAKML 126
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 136-199 6.50e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 38.75  E-value: 6.50e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039781485 136 IGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGI 199
Cdd:cd17390    33 IGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGI 96
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 137-214 6.78e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 38.71  E-value: 6.78e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039781485 137 GILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTY-ALLFVARTLQGIGSSFSSVAGLGMLAS 214
Cdd:cd17504   220 GLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSlWALVVALLLIGIGLGLAFASLPNIVVE 298
PRK14995 PRK14995
SmvA family efflux MFS transporter;
145-226 6.81e-03

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 38.94  E-value: 6.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 145 LMQLLVNPfVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASVYTDNYERGR 224
Cdd:PRK14995   53 VMAGMVLP-MGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFTEEKQRNM 131


                  ..
gi 1039781485 225 AM 226
Cdd:PRK14995  132 AL 133
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 133-216 6.94e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 38.74  E-value: 6.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 133 NVRIGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGssfssVAGLGML 212
Cdd:cd17316    35 LLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIG-----IGGEYPG 109


                  ....
gi 1039781485 213 ASVY 216
Cdd:cd17316   110 ASTY 113
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 149-427 7.10e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 38.79  E-value: 7.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 149 LVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASVYTDNYERGRAMGI 228
Cdd:cd17355    53 LAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGI 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 229 ALGGLALGLLVGAPFGSVMYEFVGKSS--------------PFLILAFLALLDGAlqfciLWPSKVSPESAMGTPLLTLL 294
Cdd:cd17355   133 LTAGGGLGSLVFLPLGAALIEAFGWRTallvlallallvlvPVLLLLRRRPADLA-----LRAYDDASPASPGSTLKEAL 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 295 KDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEwQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVG 374
Cdd:cd17355   208 RSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPA-AAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRA 286

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039781485 375 ISLLCVPLAHN-IFGLIGPNAGLGF---AIGPSTGGVIVPVIGFPWLMVIIGTINII 427
Cdd:cd17355   287 LGLALLLLLPFpPLALLLFAALFGLgwgATVPLTAALAARYFGARSYGTLFGLVFAP 343
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 134-215 9.48e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 38.31  E-value: 9.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039781485 134 VRIGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAF---SGTYALLFVARTLQGIGSSFSSVAGLG 210
Cdd:cd17321   204 LQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALlgaDSSVWLLLPGLVLLGLGLGLFATPLTN 283


                  ....*
gi 1039781485 211 MLASV 215
Cdd:cd17321   284 AALSS 288
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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