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Conserved domains on  [gi|1039780433|ref|XP_017167897|]
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striatin-4 isoform X2 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 311-633 9.68e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 196.02  E-value: 9.68e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 311 PKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQkavtakknaalDVEPIHAFRAHRGPVLAVTMGSNSEYCYSG 390
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 391 GADARIHSWKIPDLNmdpydgydpsvLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDpsssGPSCLCTFPMDGE 470
Cdd:cd00200    70 SSDKTIRLWDLETGE-----------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD----VETGKCLTTLRGH 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 471 HGIPTSVAFTSTEpaHVVASFRSGDTV-LYDLEAGSALLTLEsrGSSGPaqINQVVSHPSQPLTITAHDDRGIRFLDNRT 549
Cdd:cd00200   135 TDWVNSVAFSPDG--TFVASSSQDGTIkLWDLRTGKCVATLT--GHTGE--VNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 550 GKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWSLDNKTCVQEITAhrkkHEEAIHAVACHPSKALIASAGADAL 629
Cdd:cd00200   209 GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG----HTNSVTSLAWSPDGKRLASGSADGT 284


                  ....
gi 1039780433 630 AKVF 633
Cdd:cd00200   285 IRIW 288
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 311-633 9.68e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 196.02  E-value: 9.68e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 311 PKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQkavtakknaalDVEPIHAFRAHRGPVLAVTMGSNSEYCYSG 390
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 391 GADARIHSWKIPDLNmdpydgydpsvLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDpsssGPSCLCTFPMDGE 470
Cdd:cd00200    70 SSDKTIRLWDLETGE-----------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD----VETGKCLTTLRGH 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 471 HGIPTSVAFTSTEpaHVVASFRSGDTV-LYDLEAGSALLTLEsrGSSGPaqINQVVSHPSQPLTITAHDDRGIRFLDNRT 549
Cdd:cd00200   135 TDWVNSVAFSPDG--TFVASSSQDGTIkLWDLRTGKCVATLT--GHTGE--VNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 550 GKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWSLDNKTCVQEITAhrkkHEEAIHAVACHPSKALIASAGADAL 629
Cdd:cd00200   209 GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG----HTNSVTSLAWSPDGKRLASGSADGT 284


                  ....
gi 1039780433 630 AKVF 633
Cdd:cd00200   285 IRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
307-632 4.61e-56

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 195.13  E-value: 4.61e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 307 KTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAvtakknaaldvEPIHAFRAHRGPVLAVTMGSNSEY 386
Cdd:COG2319   108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG-----------KLLRTLTGHSGAVTSVAFSPDGKL 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 387 CYSGGADARIHSWKIPDLNmdpydgydpsvLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSssGPSCLCTFP 466
Cdd:COG2319   177 LASGSDDGTVRLWDLATGK-----------LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA--TGKLLRTLT 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 467 mdGEHGIPTSVAFtSTEPAHVVASFRSGDTVLYDLEAGSALLTLESRGSSgpaqINQVVSHPSQPLTITAHDDRGIRFLD 546
Cdd:COG2319   244 --GHSGSVRSVAF-SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG----VNSVAFSPDGKLLASGSDDGTVRLWD 316

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 547 NRTGKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWSLDNKTCVQEITAhrkkHEEAIHAVACHPSKALIASAGA 626
Cdd:COG2319   317 LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG----HTGAVTSVAFSPDGRTLASGSA 392


                  ....*.
gi 1039780433 627 DALAKV 632
Cdd:COG2319   393 DGTVRL 398
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 414-453 2.47e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 58.48  E-value: 2.47e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039780433  414 PSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD 453
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
419-453 2.49e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 55.81  E-value: 2.49e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1039780433 419 HVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD 453
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 311-633 9.68e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 196.02  E-value: 9.68e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 311 PKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQkavtakknaalDVEPIHAFRAHRGPVLAVTMGSNSEYCYSG 390
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 391 GADARIHSWKIPDLNmdpydgydpsvLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDpsssGPSCLCTFPMDGE 470
Cdd:cd00200    70 SSDKTIRLWDLETGE-----------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD----VETGKCLTTLRGH 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 471 HGIPTSVAFTSTEpaHVVASFRSGDTV-LYDLEAGSALLTLEsrGSSGPaqINQVVSHPSQPLTITAHDDRGIRFLDNRT 549
Cdd:cd00200   135 TDWVNSVAFSPDG--TFVASSSQDGTIkLWDLRTGKCVATLT--GHTGE--VNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 550 GKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWSLDNKTCVQEITAhrkkHEEAIHAVACHPSKALIASAGADAL 629
Cdd:cd00200   209 GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG----HTNSVTSLAWSPDGKRLASGSADGT 284


                  ....
gi 1039780433 630 AKVF 633
Cdd:cd00200   285 IRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
307-632 4.61e-56

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 195.13  E-value: 4.61e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 307 KTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAvtakknaaldvEPIHAFRAHRGPVLAVTMGSNSEY 386
Cdd:COG2319   108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG-----------KLLRTLTGHSGAVTSVAFSPDGKL 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 387 CYSGGADARIHSWKIPDLNmdpydgydpsvLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSssGPSCLCTFP 466
Cdd:COG2319   177 LASGSDDGTVRLWDLATGK-----------LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA--TGKLLRTLT 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 467 mdGEHGIPTSVAFtSTEPAHVVASFRSGDTVLYDLEAGSALLTLESRGSSgpaqINQVVSHPSQPLTITAHDDRGIRFLD 546
Cdd:COG2319   244 --GHSGSVRSVAF-SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG----VNSVAFSPDGKLLASGSDDGTVRLWD 316

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 547 NRTGKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWSLDNKTCVQEITAhrkkHEEAIHAVACHPSKALIASAGA 626
Cdd:COG2319   317 LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG----HTGAVTSVAFSPDGRTLASGSA 392


                  ....*.
gi 1039780433 627 DALAKV 632
Cdd:COG2319   393 DGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 298-588 2.47e-46

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 165.59  E-value: 2.47e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 298 LSDSKDAFKKTWN-----PKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKavtakknaaldVEPIHAFRAHR 372
Cdd:cd00200    25 ATGSGDGTIKVWDletgeLLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET-----------GECVRTLTGHT 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 373 GPVLAVTMGSNSEYCYSGGADARIHSWKIPDlnmdpydgydpSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIW 452
Cdd:cd00200    94 SYVSSVAFSPDGRILSSSSRDKTIKVWDVET-----------GKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 453 DPSSSgpSCLCTFPmdGEHGIPTSVAFTSTEPAHVVASfrSGDTV-LYDLEAGSALLTLESRgssgPAQINQVVSHPSQP 531
Cdd:cd00200   163 DLRTG--KCVATLT--GHTGEVNSVAFSPDGEKLLSSS--SDGTIkLWDLSTGKCLGTLRGH----ENGVNSVAFSPDGY 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039780433 532 LTITAHDDRGIRFLDNRTGKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWS 588
Cdd:cd00200   233 LLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
298-591 4.36e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 162.39  E-value: 4.36e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 298 LSDSKDAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAvtakknaaldvEPIHAFRAHR 372
Cdd:COG2319   136 ASGSADGTVRLWDLAtgkllRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG-----------KLLRTLTGHT 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 373 GPVLAVTMGSNSEYCYSGGADARIHSWkipdlnmDPYDGydpsVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIW 452
Cdd:COG2319   205 GAVRSVAFSPDGKLLASGSADGTVRLW-------DLATG----KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 453 DPSssGPSCLCTFpmDGEHGIPTSVAFTSTepAHVVASFRSGDTV-LYDLEAGSALLTLESRGssgpAQINQVVSHPSQP 531
Cdd:COG2319   274 DLA--TGELLRTL--TGHSGGVNSVAFSPD--GKLLASGSDDGTVrLWDLATGKLLRTLTGHT----GAVRSVAFSPDGK 343

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 532 LTITAHDDRGIRFLDNRTGKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWSLDN 591
Cdd:COG2319   344 TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
313-633 3.52e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 154.30  E-value: 3.52e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 313 FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWnlqkavtakknAALDVEPIHAFRAHRGPVLAVTMGSNSEYCYSGGA 392
Cdd:COG2319    30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLL-----------DAAAGALLATLLGHTAAVLSVAFSPDGRLLASASA 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 393 DARIHSWKIpdlnmdpydgyDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSsgPSCLCTFPmdGEHG 472
Cdd:COG2319    99 DGTVRLWDL-----------ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT--GKLLRTLT--GHSG 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 473 IPTSVAFTSTEpaHVVASFRSGDTV-LYDLEAGSALLTLesRGSSGPaqINQVVSHPSQPLTITAHDDRGIRFLDNRTGK 551
Cdd:COG2319   164 AVTSVAFSPDG--KLLASGSDDGTVrLWDLATGKLLRTL--TGHTGA--VRSVAFSPDGKLLASGSADGTVRLWDLATGK 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 552 SVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWSLDNKTCVQEITAHrkkhEEAIHAVACHPSKALIASAGADALAK 631
Cdd:COG2319   238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH----SGGVNSVAFSPDGKLLASGSDDGTVR 313


                  ..
gi 1039780433 632 VF 633
Cdd:COG2319   314 LW 315
WD40 COG2319
WD40 repeat [General function prediction only];
432-633 1.26e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.43  E-value: 1.26e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 432 AFSPTSQRLASCSADGTVRIWDPSSSGPSclctfPMDGEHGIPTSVAFTSTEPAHVVASFRSGDTVLYDLEAGSALLTLE 511
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALL-----LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 512 SRGSSgpaqINQVVSHPSQPLTITAHDDRGIRFLDNRTGKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWSLDN 591
Cdd:COG2319    76 GHTAA----VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1039780433 592 KTCVQEITAhrkkHEEAIHAVACHPSKALIASAGADALAKVF 633
Cdd:COG2319   152 GKLLRTLTG----HSGAVTSVAFSPDGKLLASGSDDGTVRLW 189
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 414-453 2.47e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 58.48  E-value: 2.47e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039780433  414 PSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD 453
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
419-453 2.49e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 55.81  E-value: 2.49e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1039780433 419 HVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD 453
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 549-588 2.46e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 2.46e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039780433  549 TGKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWS 588
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 308-347 3.47e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 3.47e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039780433  308 TWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWN 347
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
550-588 3.77e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.65  E-value: 3.77e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1039780433 550 GKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWS 588
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
309-347 5.92e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 5.92e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1039780433 309 WNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWN 347
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 428-573 7.00e-04

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 42.21  E-value: 7.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039780433 428 VW--GLAF-SPTSQR-LASCSADGTVRIWDPSSSG-PSCLCTFpmdGEHGIpTSVAfTSTEPAHVVASFRSGDTVLYDLE 502
Cdd:cd22857   179 VWvtDLTFlSKDDHRkIVTGTGYHQVRLYDTRAQRrPVVSVDF---GETPI-KAVA-EDPDGHTVYVGDTSGDLASIDLR 253

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039780433 503 AGSALLTLesRGSSGpAQINQVVSHPSQPLTITAHDDRGIRFLDNRTGKSVHSMVA--HLdavTCLAVDPNGV 573
Cdd:cd22857   254 TGKLLGCF--KGKCG-GSIRSIARHPELPLIASCGLDRYLRIWDTETRQLLSKVYLkqRL---TAVVFDSSFS 320
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 550-587 1.79e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 40.83  E-value: 1.79e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1039780433 550 GKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLW 587
Cdd:pfam20426 114 GRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVW 151
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 363-400 2.92e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 2.92e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1039780433  363 EPIHAFRAHRGPVLAVTMGSNSEYCYSGGADARIHSWK 400
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
363-399 6.59e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 6.59e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1039780433 363 EPIHAFRAHRGPVLAVTMGSNSEYCYSGGADARIHSW 399
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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