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Conserved domains on  [gi|1034595608|ref|XP_016879045|]
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inactive rhomboid protein 1 isoform X3 [Homo sapiens]

Protein Classification

inactive rhomboid protein( domain architecture ID 10576411)

inactive rhomboid protein regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation; does not exhibit any protease activity on its own

CATH:  1.20.1540.10
MEROPS:  S54
SCOP:  4000471

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Rhomboid_SP pfam12595
Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 ...
114-308 1.39e-112

Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 amino acids in length. The family is found in association with pfam01694. Rhomboid is a seven-transmembrane spanning protein that resides in the Golgi and acts as a serine protease to cleave Spitz.


:

Pssm-ID: 463639  Cd Length: 193  Bit Score: 342.24  E-value: 1.39e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595608 114 VSKDSDSTQKWQRKSIRHCSQRYGKLKPQVLRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQKIIDPLARGRAFRVADD 193
Cdd:pfam12595   1 VSKDSDSTQRWQRKSLRHCSMRYGKLKPQVIREMELPSQDNPSLTSTETPPPLYLPKSHHGMQRIVDPLARGRAFRMVEE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595608 194 tAEGLSAPHTPVTPGAASLCSFSSSRSGFHRLPRRRKRESVAKMSFRAAAALMKGRSVRDGTFRRAQRRSFTPASFLEED 273
Cdd:pfam12595  81 -VDGYSVPQTPITPGVASLCSFTSSRSGLNRLPRRRKRESVAKMSFRAAAALMKGRSLRESTLRRRRRRSFTPPSFLEED 159
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1034595608 274 TTDFPDELDTSFFAREGiLHEELSTYPDEVFESPS 308
Cdd:pfam12595 160 TVDFADELDTSFFSKDD-LHEELSSMADEVFESPS 193
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
670-813 5.37e-35

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


:

Pssm-ID: 426384  Cd Length: 147  Bit Score: 130.03  E-value: 5.37e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595608 670 PEVPDQFYRLWLSLFLHAGILHCLVSICFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPY-RAEVGPAGSQFG 748
Cdd:pfam01694   1 PVQPGQLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLsTPSVGASGAIFG 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034595608 749 ILACLFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPW--IDNFAHISGFISGLFLSFAFLPYI 813
Cdd:pfam01694  81 LLGALLVLGPRNRILLFGLIGALLALLLFILLNLVLGLLPGngVSNLAHLGGLLVGLLLGFILLRRP 147
 
Name Accession Description Interval E-value
Rhomboid_SP pfam12595
Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 ...
114-308 1.39e-112

Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 amino acids in length. The family is found in association with pfam01694. Rhomboid is a seven-transmembrane spanning protein that resides in the Golgi and acts as a serine protease to cleave Spitz.


Pssm-ID: 463639  Cd Length: 193  Bit Score: 342.24  E-value: 1.39e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595608 114 VSKDSDSTQKWQRKSIRHCSQRYGKLKPQVLRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQKIIDPLARGRAFRVADD 193
Cdd:pfam12595   1 VSKDSDSTQRWQRKSLRHCSMRYGKLKPQVIREMELPSQDNPSLTSTETPPPLYLPKSHHGMQRIVDPLARGRAFRMVEE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595608 194 tAEGLSAPHTPVTPGAASLCSFSSSRSGFHRLPRRRKRESVAKMSFRAAAALMKGRSVRDGTFRRAQRRSFTPASFLEED 273
Cdd:pfam12595  81 -VDGYSVPQTPITPGVASLCSFTSSRSGLNRLPRRRKRESVAKMSFRAAAALMKGRSLRESTLRRRRRRSFTPPSFLEED 159
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1034595608 274 TTDFPDELDTSFFAREGiLHEELSTYPDEVFESPS 308
Cdd:pfam12595 160 TVDFADELDTSFFSKDD-LHEELSSMADEVFESPS 193
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
670-813 5.37e-35

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 130.03  E-value: 5.37e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595608 670 PEVPDQFYRLWLSLFLHAGILHCLVSICFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPY-RAEVGPAGSQFG 748
Cdd:pfam01694   1 PVQPGQLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLsTPSVGASGAIFG 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034595608 749 ILACLFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPW--IDNFAHISGFISGLFLSFAFLPYI 813
Cdd:pfam01694  81 LLGALLVLGPRNRILLFGLIGALLALLLFILLNLVLGLLPGngVSNLAHLGGLLVGLLLGFILLRRP 147
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
675-811 1.32e-21

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 93.39  E-value: 1.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595608 675 QFYRLWLSLFLHAGILHclvsICFQMTVL----RDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAE--VGPAGSQFG 748
Cdd:COG0705    42 ELWRLLTSMFLHGGFLH----LLFNMLALwvfgPLLERRLGSKRFLLLYLLSGLGGGLLQLLFSPGSGYplVGASGAIFG 117
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034595608 749 ILACLFV-ELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPW--IDNFAHISGFISGLFLSFAFLP 811
Cdd:COG0705   118 LLGALLVlGPRRRVLLLFIPIPALLFLLVWLLLGLLFGLLGGggIAWEAHLGGLLAGLLLALLLRK 183
PTZ00101 PTZ00101
rhomboid-1 protease; Provisional
675-803 9.07e-14

rhomboid-1 protease; Provisional


Pssm-ID: 185445  Cd Length: 278  Bit Score: 72.58  E-value: 9.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595608 675 QFYRLWLSLFLHAGILHCLVSICFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNL--ASAIFLPYRaeVGPAGSQFGILAC 752
Cdd:PTZ00101  101 EIHRLILPIFLHANIFHTFFNVFFQLRMGFTLEKNYGIVKIIILYFLTGIYGNIlsSSVTYCPIK--VGASTSGMGLLGI 178
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1034595608 753 LFVELFQSWQILARPWRAFFKL----LAVVLFLFTFGLLPwIDNFAHISGFISGL 803
Cdd:PTZ00101  179 VTSELILLWHVIRHRERVVFNIiffsLISFFYYFTFNGSN-IDHVGHLGGLLSGI 232
 
Name Accession Description Interval E-value
Rhomboid_SP pfam12595
Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 ...
114-308 1.39e-112

Rhomboid serine protease; This domain family is found in eukaryotes, and is approximately 210 amino acids in length. The family is found in association with pfam01694. Rhomboid is a seven-transmembrane spanning protein that resides in the Golgi and acts as a serine protease to cleave Spitz.


Pssm-ID: 463639  Cd Length: 193  Bit Score: 342.24  E-value: 1.39e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595608 114 VSKDSDSTQKWQRKSIRHCSQRYGKLKPQVLRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQKIIDPLARGRAFRVADD 193
Cdd:pfam12595   1 VSKDSDSTQRWQRKSLRHCSMRYGKLKPQVIREMELPSQDNPSLTSTETPPPLYLPKSHHGMQRIVDPLARGRAFRMVEE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595608 194 tAEGLSAPHTPVTPGAASLCSFSSSRSGFHRLPRRRKRESVAKMSFRAAAALMKGRSVRDGTFRRAQRRSFTPASFLEED 273
Cdd:pfam12595  81 -VDGYSVPQTPITPGVASLCSFTSSRSGLNRLPRRRKRESVAKMSFRAAAALMKGRSLRESTLRRRRRRSFTPPSFLEED 159
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1034595608 274 TTDFPDELDTSFFAREGiLHEELSTYPDEVFESPS 308
Cdd:pfam12595 160 TVDFADELDTSFFSKDD-LHEELSSMADEVFESPS 193
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
670-813 5.37e-35

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 130.03  E-value: 5.37e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595608 670 PEVPDQFYRLWLSLFLHAGILHCLVSICFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPY-RAEVGPAGSQFG 748
Cdd:pfam01694   1 PVQPGQLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLsTPSVGASGAIFG 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034595608 749 ILACLFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPW--IDNFAHISGFISGLFLSFAFLPYI 813
Cdd:pfam01694  81 LLGALLVLGPRNRILLFGLIGALLALLLFILLNLVLGLLPGngVSNLAHLGGLLVGLLLGFILLRRP 147
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
675-811 1.32e-21

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 93.39  E-value: 1.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595608 675 QFYRLWLSLFLHAGILHclvsICFQMTVL----RDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAE--VGPAGSQFG 748
Cdd:COG0705    42 ELWRLLTSMFLHGGFLH----LLFNMLALwvfgPLLERRLGSKRFLLLYLLSGLGGGLLQLLFSPGSGYplVGASGAIFG 117
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034595608 749 ILACLFV-ELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPW--IDNFAHISGFISGLFLSFAFLP 811
Cdd:COG0705   118 LLGALLVlGPRRRVLLLFIPIPALLFLLVWLLLGLLFGLLGGggIAWEAHLGGLLAGLLLALLLRK 183
PTZ00101 PTZ00101
rhomboid-1 protease; Provisional
675-803 9.07e-14

rhomboid-1 protease; Provisional


Pssm-ID: 185445  Cd Length: 278  Bit Score: 72.58  E-value: 9.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595608 675 QFYRLWLSLFLHAGILHCLVSICFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNL--ASAIFLPYRaeVGPAGSQFGILAC 752
Cdd:PTZ00101  101 EIHRLILPIFLHANIFHTFFNVFFQLRMGFTLEKNYGIVKIIILYFLTGIYGNIlsSSVTYCPIK--VGASTSGMGLLGI 178
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1034595608 753 LFVELFQSWQILARPWRAFFKL----LAVVLFLFTFGLLPwIDNFAHISGFISGL 803
Cdd:PTZ00101  179 VTSELILLWHVIRHRERVVFNIiffsLISFFYYFTFNGSN-IDHVGHLGGLLSGI 232
7TMR-DISM_7TM pfam07695
7TM diverse intracellular signalling; This entry represents the transmembrane region of the ...
664-808 1.87e-04

7TM diverse intracellular signalling; This entry represents the transmembrane region of the 7TM-DISM (7TM Receptors with Diverse Intracellular Signalling Modules).


Pssm-ID: 429600 [Multi-domain]  Cd Length: 207  Bit Score: 43.42  E-value: 1.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595608 664 LLPFLNPEVPDQF--YRLWLSLFLHAGILHCLvsicFQMTVLrDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVg 741
Cdd:pfam07695  52 GFQYLWPNAPPWLnnKLLYLSLLLLLPFFALL----FARSFL-ELKKYLPRLLRLLLGLALLLALLLLLLPLFPYTLSL- 125
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034595608 742 PAGSQFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFT--------FGLLP---WIDNFAHISGFISGLFLSFA 808
Cdd:pfam07695 126 PLAQLLALLFILFLLLLGIIAWRKGYKPARYFLLAWLLLLIGalidilslLGLLPsnfFTNYLLQIGSALEVLLLSLA 203
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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