NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1034569550|ref|XP_016872144|]
View 

transmembrane protein 180 isoform X1 [Homo sapiens]

Protein Classification

major facilitator superfamily domain-containing 13A( domain architecture ID 13024743)

major facilitator superfamily domain-containing 13A (MFSD13A) is a multi-pass membrane protein that acts as a cation symporter

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
MFS_MFSD13A cd17481
Major facilitator superfamily domain containing 13A; Human major facilitator superfamily ...
17-500 0e+00

Major facilitator superfamily domain containing 13A; Human major facilitator superfamily domain containing 13A (MFSD1A) protein is also called transmembrane protein 180. Its function is still unknown. MFSD13A belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement


:

Pssm-ID: 341034  Cd Length: 429  Bit Score: 640.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550  17 VVYGSLALFTTILHNVFLLYYVDTFVSVYKINKMAFWVGETVFLLWNSLNDPLFGWLSDRQFLSSQPrSGAGLSSRAVVL 96
Cdd:cd17481     1 VAYGSLAFFLSILHNVFLLYYVDVFVSVYKIDKASFWIGETIFLIWNSLNDPLFGWLSDRKFLSSSS-SGAHISSPAVVL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550  97 ARVQALGWHGPLLALSFLAFWVPWAPAGLQFLLCLCLYDGFLTLVDLHHHALLADLALSAHDRTHLNFYCSLFSAAGSLS 176
Cdd:cd17481    80 KRLRALSINGPLFALSFLAFWVPWAPPGLQFVVCLCLYDGFLTMVDLNHNALLADLAVSAEDRTRLNSYCSVFSAIGSLS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 177 VFASYAFWNKEDFSSFRAFCVTLAVSSGLGFLGATQLLrrrveaarkdpgcsglvvdsglcgeellvgseeadsitlgry 256
Cdd:cd17481   160 VFLSYAVWDKENLGSFRIFCACLAIISAVGFFLSSALL------------------------------------------ 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 257 lrqlarhrNFLWFVSMDLVQVFHCHFNSNFFPLFLEHLLSDHISLSTGSILLGLSYVAPHLNNLYFLSLCRRWGVYAVVR 336
Cdd:cd17481   198 --------NFLWFVVMNLVQVFHCHFNSNFFPLFLEHLLGDHISPSTGSVLLGISFVAPHLNNLYFLSLCRRYGVYNVVR 269
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 337 GLFLLKLGLSLLMLLAGPDHLSLLCLFIASNRVFTEGTCKLLTLVVTDLVDEDLVLNHRKQAASALLFGMVALVTKPGQT 416
Cdd:cd17481   270 GLFLIKLGLSLAMLLAGPDLLWLLCLFIASNRVFTEGTCKLLNLVISDLVDEDYVLNHRKQAISALVFGTAALLSKPGQT 349
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 417 FAPLLGTWLLCFYTGHDLFQQSLITPVgsahPWPEPPAPAPAQAPTLRQGCFYLLVLVPITCALLQLFTWSQFTLHGRRL 496
Cdd:cd17481   350 LAPLIGTWLLCVQTGSDLFQTGAEPGS----IKQQQSSADEASTQTLRQGCFYLLVYVPIVCALIQLLAWSQFTLHGRRL 425

                  ....
gi 1034569550 497 HMVK 500
Cdd:cd17481   426 QYVK 429
 
Name Accession Description Interval E-value
MFS_MFSD13A cd17481
Major facilitator superfamily domain containing 13A; Human major facilitator superfamily ...
17-500 0e+00

Major facilitator superfamily domain containing 13A; Human major facilitator superfamily domain containing 13A (MFSD1A) protein is also called transmembrane protein 180. Its function is still unknown. MFSD13A belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement


Pssm-ID: 341034  Cd Length: 429  Bit Score: 640.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550  17 VVYGSLALFTTILHNVFLLYYVDTFVSVYKINKMAFWVGETVFLLWNSLNDPLFGWLSDRQFLSSQPrSGAGLSSRAVVL 96
Cdd:cd17481     1 VAYGSLAFFLSILHNVFLLYYVDVFVSVYKIDKASFWIGETIFLIWNSLNDPLFGWLSDRKFLSSSS-SGAHISSPAVVL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550  97 ARVQALGWHGPLLALSFLAFWVPWAPAGLQFLLCLCLYDGFLTLVDLHHHALLADLALSAHDRTHLNFYCSLFSAAGSLS 176
Cdd:cd17481    80 KRLRALSINGPLFALSFLAFWVPWAPPGLQFVVCLCLYDGFLTMVDLNHNALLADLAVSAEDRTRLNSYCSVFSAIGSLS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 177 VFASYAFWNKEDFSSFRAFCVTLAVSSGLGFLGATQLLrrrveaarkdpgcsglvvdsglcgeellvgseeadsitlgry 256
Cdd:cd17481   160 VFLSYAVWDKENLGSFRIFCACLAIISAVGFFLSSALL------------------------------------------ 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 257 lrqlarhrNFLWFVSMDLVQVFHCHFNSNFFPLFLEHLLSDHISLSTGSILLGLSYVAPHLNNLYFLSLCRRWGVYAVVR 336
Cdd:cd17481   198 --------NFLWFVVMNLVQVFHCHFNSNFFPLFLEHLLGDHISPSTGSVLLGISFVAPHLNNLYFLSLCRRYGVYNVVR 269
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 337 GLFLLKLGLSLLMLLAGPDHLSLLCLFIASNRVFTEGTCKLLTLVVTDLVDEDLVLNHRKQAASALLFGMVALVTKPGQT 416
Cdd:cd17481   270 GLFLIKLGLSLAMLLAGPDLLWLLCLFIASNRVFTEGTCKLLNLVISDLVDEDYVLNHRKQAISALVFGTAALLSKPGQT 349
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 417 FAPLLGTWLLCFYTGHDLFQQSLITPVgsahPWPEPPAPAPAQAPTLRQGCFYLLVLVPITCALLQLFTWSQFTLHGRRL 496
Cdd:cd17481   350 LAPLIGTWLLCVQTGSDLFQTGAEPGS----IKQQQSSADEASTQTLRQGCFYLLVYVPIVCALIQLLAWSQFTLHGRRL 425

                  ....
gi 1034569550 497 HMVK 500
Cdd:cd17481   426 QYVK 429
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
11-426 1.60e-12

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 69.55  E-value: 1.60e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550  11 LGLPTAVVYGSLALFTTILHNVFLLYYVDTFVSVYKINkmAFWVGeTVFL---LWNSLNDPLFGWLSDRqflsSQPRSGA 87
Cdd:COG2211     7 LSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLS--AALVG-LILLvarLWDAITDPLIGALSDR----TRTRWGR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550  88 glssravvlaRVQALGWHGPLLALSFLAFWV--PWAPAG--LQFLLCLCLYDGFLTLVDLHHHALLADLALSAHDRTHLN 163
Cdd:COG2211    80 ----------RRPWILIGAIPLALSFVLLFTapDLSPTGklIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLS 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 164 FYCSLFSAAGSLSVFAS----YAFWNKEDFSSFRAFCVTLAVSSGLGFLGATQLLRRRVEAARKdpgcsglvvdsglcge 239
Cdd:COG2211   150 SWRFAFAGLGGLLASVLppplVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEE---------------- 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 240 ellvgseeadSITLGRYLRQLARHRNFLWFVSMDLVQVFHCHFNSNFFPLFLEHLLsdHISLSTGSILLGLSYVAphlnn 319
Cdd:COG2211   214 ----------KVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVL--GLSAALVGLLLALYFLA----- 276
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 320 lYFLS------LCRRWGVYAVVRGLFLLKLGLSLLMLLAGPDHLSLLCLFIASNRVFTEGTCKLLTLVVTDLVDEDLVLN 393
Cdd:COG2211   277 -ALLGaplwprLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKT 355
                         410       420       430
                  ....*....|....*....|....*....|...
gi 1034569550 394 HRKQAasALLFGMVALVTKPGQTFAPLLGTWLL 426
Cdd:COG2211   356 GRRRE--GLYFGIFTFAIKLGQALAGALAGLLL 386
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
19-426 2.54e-09

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 59.24  E-value: 2.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550  19 YGSLA--LFTTILHNVFLLYYVDtfvsVYKINkmAFWVGETVFL--LWNSLNDPLFGWLSDRqflsSQPRSGAGLSsrAV 94
Cdd:pfam13347   4 SGALAagIKYAGLATYLLYFYTD----VLGLS--AAAVGLVLLVarLVDAFTDPIVGHIIDR----TRTRWGRRRP--WL 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550  95 VLArvqalgwhGPLLALSFLAFWVP--WAPAGLQ--FLLCLCLYDGFLTLVDLHHHALLADLALSAHDRTHLNFYCSLFS 170
Cdd:pfam13347  72 LLS--------AIILAVSFILLFTPpeLGRAPLFiwLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFS 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 171 AAGSLSV----FASYAFWN--KEDFSSFRAFCVTLAVSSGLGFLGATQLLRRRVEAARKDPGCSglvvdsglcgeellvg 244
Cdd:pfam13347 144 VGGGLLAaalaFPLVLILGgtGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEDTGQ---------------- 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 245 seeADSITLGRYLRQLARHRNFLWFVSMDLVQVFHCHFNSNFFPLFLEHLLSDhisLSTGSILLGLSYVAPHLNNLYFLS 324
Cdd:pfam13347 208 ---KEAGSLLDMLKEVFRNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLGN---GFAASAFPLVFTIGALLGIPLWPP 281
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 325 LCRRWGVYAVVRGLFLLKLGLSLLMLLAGPDHLSLLCLFIASNRVFTEGTCKLLTLVVTDLVDEDLVLNHRKqaASALLF 404
Cdd:pfam13347 282 LAKRIGKKNTYILGALITIAGFALALLLGPNNTLLFLVLYIIIGFGYGSSFFLPWSMLADVVDYGELRTGKR--REGTFF 359
                         410       420
                  ....*....|....*....|..
gi 1034569550 405 GMVALVTKPGQTFAPLLGTWLL 426
Cdd:pfam13347 360 AMWSFISKLATGVGLGVSGLLL 381
 
Name Accession Description Interval E-value
MFS_MFSD13A cd17481
Major facilitator superfamily domain containing 13A; Human major facilitator superfamily ...
17-500 0e+00

Major facilitator superfamily domain containing 13A; Human major facilitator superfamily domain containing 13A (MFSD1A) protein is also called transmembrane protein 180. Its function is still unknown. MFSD13A belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement


Pssm-ID: 341034  Cd Length: 429  Bit Score: 640.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550  17 VVYGSLALFTTILHNVFLLYYVDTFVSVYKINKMAFWVGETVFLLWNSLNDPLFGWLSDRQFLSSQPrSGAGLSSRAVVL 96
Cdd:cd17481     1 VAYGSLAFFLSILHNVFLLYYVDVFVSVYKIDKASFWIGETIFLIWNSLNDPLFGWLSDRKFLSSSS-SGAHISSPAVVL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550  97 ARVQALGWHGPLLALSFLAFWVPWAPAGLQFLLCLCLYDGFLTLVDLHHHALLADLALSAHDRTHLNFYCSLFSAAGSLS 176
Cdd:cd17481    80 KRLRALSINGPLFALSFLAFWVPWAPPGLQFVVCLCLYDGFLTMVDLNHNALLADLAVSAEDRTRLNSYCSVFSAIGSLS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 177 VFASYAFWNKEDFSSFRAFCVTLAVSSGLGFLGATQLLrrrveaarkdpgcsglvvdsglcgeellvgseeadsitlgry 256
Cdd:cd17481   160 VFLSYAVWDKENLGSFRIFCACLAIISAVGFFLSSALL------------------------------------------ 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 257 lrqlarhrNFLWFVSMDLVQVFHCHFNSNFFPLFLEHLLSDHISLSTGSILLGLSYVAPHLNNLYFLSLCRRWGVYAVVR 336
Cdd:cd17481   198 --------NFLWFVVMNLVQVFHCHFNSNFFPLFLEHLLGDHISPSTGSVLLGISFVAPHLNNLYFLSLCRRYGVYNVVR 269
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 337 GLFLLKLGLSLLMLLAGPDHLSLLCLFIASNRVFTEGTCKLLTLVVTDLVDEDLVLNHRKQAASALLFGMVALVTKPGQT 416
Cdd:cd17481   270 GLFLIKLGLSLAMLLAGPDLLWLLCLFIASNRVFTEGTCKLLNLVISDLVDEDYVLNHRKQAISALVFGTAALLSKPGQT 349
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 417 FAPLLGTWLLCFYTGHDLFQQSLITPVgsahPWPEPPAPAPAQAPTLRQGCFYLLVLVPITCALLQLFTWSQFTLHGRRL 496
Cdd:cd17481   350 LAPLIGTWLLCVQTGSDLFQTGAEPGS----IKQQQSSADEASTQTLRQGCFYLLVYVPIVCALIQLLAWSQFTLHGRRL 425

                  ....
gi 1034569550 497 HMVK 500
Cdd:cd17481   426 QYVK 429
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
11-426 1.60e-12

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 69.55  E-value: 1.60e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550  11 LGLPTAVVYGSLALFTTILHNVFLLYYVDTFVSVYKINkmAFWVGeTVFL---LWNSLNDPLFGWLSDRqflsSQPRSGA 87
Cdd:COG2211     7 LSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLS--AALVG-LILLvarLWDAITDPLIGALSDR----TRTRWGR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550  88 glssravvlaRVQALGWHGPLLALSFLAFWV--PWAPAG--LQFLLCLCLYDGFLTLVDLHHHALLADLALSAHDRTHLN 163
Cdd:COG2211    80 ----------RRPWILIGAIPLALSFVLLFTapDLSPTGklIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLS 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 164 FYCSLFSAAGSLSVFAS----YAFWNKEDFSSFRAFCVTLAVSSGLGFLGATQLLRRRVEAARKdpgcsglvvdsglcge 239
Cdd:COG2211   150 SWRFAFAGLGGLLASVLppplVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEE---------------- 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 240 ellvgseeadSITLGRYLRQLARHRNFLWFVSMDLVQVFHCHFNSNFFPLFLEHLLsdHISLSTGSILLGLSYVAphlnn 319
Cdd:COG2211   214 ----------KVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVL--GLSAALVGLLLALYFLA----- 276
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 320 lYFLS------LCRRWGVYAVVRGLFLLKLGLSLLMLLAGPDHLSLLCLFIASNRVFTEGTCKLLTLVVTDLVDEDLVLN 393
Cdd:COG2211   277 -ALLGaplwprLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKT 355
                         410       420       430
                  ....*....|....*....|....*....|...
gi 1034569550 394 HRKQAasALLFGMVALVTKPGQTFAPLLGTWLL 426
Cdd:COG2211   356 GRRRE--GLYFGIFTFAIKLGQALAGALAGLLL 386
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
19-426 2.54e-09

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 59.24  E-value: 2.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550  19 YGSLA--LFTTILHNVFLLYYVDtfvsVYKINkmAFWVGETVFL--LWNSLNDPLFGWLSDRqflsSQPRSGAGLSsrAV 94
Cdd:pfam13347   4 SGALAagIKYAGLATYLLYFYTD----VLGLS--AAAVGLVLLVarLVDAFTDPIVGHIIDR----TRTRWGRRRP--WL 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550  95 VLArvqalgwhGPLLALSFLAFWVP--WAPAGLQ--FLLCLCLYDGFLTLVDLHHHALLADLALSAHDRTHLNFYCSLFS 170
Cdd:pfam13347  72 LLS--------AIILAVSFILLFTPpeLGRAPLFiwLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFS 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 171 AAGSLSV----FASYAFWN--KEDFSSFRAFCVTLAVSSGLGFLGATQLLRRRVEAARKDPGCSglvvdsglcgeellvg 244
Cdd:pfam13347 144 VGGGLLAaalaFPLVLILGgtGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEDTGQ---------------- 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 245 seeADSITLGRYLRQLARHRNFLWFVSMDLVQVFHCHFNSNFFPLFLEHLLSDhisLSTGSILLGLSYVAPHLNNLYFLS 324
Cdd:pfam13347 208 ---KEAGSLLDMLKEVFRNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLGN---GFAASAFPLVFTIGALLGIPLWPP 281
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 325 LCRRWGVYAVVRGLFLLKLGLSLLMLLAGPDHLSLLCLFIASNRVFTEGTCKLLTLVVTDLVDEDLVLNHRKqaASALLF 404
Cdd:pfam13347 282 LAKRIGKKNTYILGALITIAGFALALLLGPNNTLLFLVLYIIIGFGYGSSFFLPWSMLADVVDYGELRTGKR--REGTFF 359
                         410       420
                  ....*....|....*....|..
gi 1034569550 405 GMVALVTKPGQTFAPLLGTWLL 426
Cdd:pfam13347 360 AMWSFISKLATGVGLGVSGLLL 381
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
19-426 1.68e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 50.12  E-value: 1.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550  19 YGSLALFTTILHNVFLLYYVDtFVSVYKINKMAFWVGETVFLLWNSLNDPLFGWLSDRQFlssqprsgaglssravvlaR 98
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPA-LLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFG-------------------R 60
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550  99 VQALGWHGPLLALSFLAFWVPWAPAGLQFLLCLClydGFLTLVDLHHHALLADLALSAHDRTHLNFYCSLFSAAGSLSVF 178
Cdd:cd06174    61 RPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLL---GLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGP 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 179 ASYAFWNKEDFSSFRAFCVTLAVSSGLGFLGATQLLRRRVEAARKDPgcsglvvdsglcgeellvgseeaDSITLGRYLR 258
Cdd:cd06174   138 LLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKN-----------------------EEASSKSVLK 194
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 259 QLARHRNFLWFVSMDLVQVFHCHFNSNFFPLFLEHLLSD-HISLSTGSILLGLSYVAPHLNNLYFLSLCRRWGVYAVVRG 337
Cdd:cd06174   195 LLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLgGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLL 274
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 338 LFLLKLGLSLLMLLAGPDHLSLLCLFIASnrVFTEGTCKLLTLVVTDLVDEdlvlnhrkQAASALLFGMVALVTKPGQTF 417
Cdd:cd06174   275 IGLLLMALGLALLLLAPSLLLLLLLLLLL--GFGLGGLLPLSFALIAELFP--------PEIRGTAFGLLNTFGFLGGAI 344

                  ....*....
gi 1034569550 418 APLLGTWLL 426
Cdd:cd06174   345 GPLLAGFLL 353
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
23-429 8.70e-06

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 47.98  E-value: 8.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550  23 ALFTTILHNVFLLYYVDTFvsvykiNKMAFWVGeTVFL---LWNSLNDPLFGWLSDRQflssqpRSGAGLSSRAVVLARV 99
Cdd:cd17332    12 NLIFQIVSTYLLFFYTDVL------GLSAAAAG-TIFLvarIIDAINDPLMGYLIDRT------RSRWGRFRPWLLWGAI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 100 qalgwhgPLLALSFLAFWVPWAPAGLQF---LLCLCLYDGFLTLVDLHHHALLADLALSAHDRTHLNFYCSLFSAAGSLS 176
Cdd:cd17332    79 -------PLALLFVLLFTTPDGSGTGKLiyaLITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLL 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 177 V------FASYaFWNKEDFSSFRAFCVTLAVSSGLGFLGATQLLRRRVEAARkdpgcsglvvdsglcgeellvgsEEADS 250
Cdd:cd17332   152 VtvlpppLVAY-FGGGNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPE-----------------------EEKSK 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 251 ITLGRYLRQLARHRNFLWFVSMDLVQVFHCHFNSNFFPLFLEHLLSDHislSTGSILLGLSYVAPHLNNLYFLSLCRRWG 330
Cdd:cd17332   208 LPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGR---AELVLLLLLILSGALLALLPWPPLKKRFG 284
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569550 331 VYAVVRGLFLLKLGLSLLMLLAGPDHLSLLCLFIASNRVFTEGTCKLLTLVVTDLVDEDLVLNHRKqaASALLFGMVALV 410
Cdd:cd17332   285 KKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLADVIDYGELKTGKR--REGIFYSVMTFF 362
                         410
                  ....*....|....*....
gi 1034569550 411 TKPGQTFAPLLGTWLLCFY 429
Cdd:cd17332   363 RKLGLALAGALVGLILSLA 381
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH