presenilin-associated rhomboid-like protein, mitochondrial isoform X4 [Homo sapiens]
Protein Classification
rhomboid family protein( domain architecture ID 229382)
rhomboid family protein may be a membrane-bound serine protease that catalyzes regulated intramembrane proteolysis, resulting in the release of functional polypeptides from their membrane anchors
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| Rhomboid super family | cl21536 | Rhomboid family; This family contains integral membrane proteins that are related to ... |
219-266 | 5.79e-04 | ||
Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite. The actual alignment was detected with superfamily member pfam01694: Pssm-ID: 451297 Cd Length: 147 Bit Score: 39.51 E-value: 5.79e-04
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| Name | Accession | Description | Interval | E-value | ||
| Rhomboid | pfam01694 | Rhomboid family; This family contains integral membrane proteins that are related to ... |
219-266 | 5.79e-04 | ||
Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite. Pssm-ID: 426384 Cd Length: 147 Bit Score: 39.51 E-value: 5.79e-04
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| Name | Accession | Description | Interval | E-value | ||
| Rhomboid | pfam01694 | Rhomboid family; This family contains integral membrane proteins that are related to ... |
219-266 | 5.79e-04 | ||
Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite. Pssm-ID: 426384 Cd Length: 147 Bit Score: 39.51 E-value: 5.79e-04
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