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Conserved domains on  [gi|1034631177|ref|XP_016861193|]
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zona pellucida-like domain-containing protein 1 isoform X1 [Homo sapiens]

Protein Classification

zona pellucida domain-containing protein( domain architecture ID 10443513)

zona pellucida (ZP) domain-containing protein may function as a structural component of egg coats, appendicularian mucous houses, and nematode dauer larvae, or as a mechanotransducer in flies, or as a receptor in mammals and nonmammals

Gene Ontology:  GO:0031012

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Zona_pellucida pfam00100
Zona pellucida-like domain;
44-314 3.37e-43

Zona pellucida-like domain;


:

Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 151.61  E-value: 3.37e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631177  44 CGVQAITMKINFCTVLFSGYsETDLALNGRHgDSHCRGFINNNTFPaVVIFIINLStleGCGNnlVVSTIPGVSAYGNat 123
Cdd:pfam00100   1 CTPDTMTVSISKCLLVPSGL-LSSLSLLGGL-DPSCKPVSNTNGSP-AVLFEFPLT---GCGT--TVQVNGTHIIYSN-- 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631177 124 svqvgNISGYIDTPDPPTIISYLPglLYKFSCSYPLEYLVNNTQLASSSAAISVRENNGTFvsTLNLLLYNDSTYNQQLI 203
Cdd:pfam00100  71 -----TLYSSTDLRSGIIRRTITR--RLPFSCSYPRSSLVSLLVVAPPSPVPITVSGSGVF--LVSMDLYYDSSYTSPYS 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631177 204 IPSIGLPLKTKVFAAVQATNL-DGRWNVLMDYCYTTPSGNPNDDIRYDLFL-SCDKDP----QTTVIENGRSQRGRFSFE 277
Cdd:pfam00100 142 PYPVTVLLGDPLYVEVSLLSRtDPNLVLVLDNCWATPSPNPTSSPQYQLIVnGCPNDGdstyPVSSLSNGPSHYVRFSFK 221
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1034631177 278 VFRFVkhkNQKMSTVFLHCVTKLCRADDCPfLMPICS 314
Cdd:pfam00100 222 AFRFV---GSSISQVYLHCSVSVCSSDSNS-CGKSCS 254
 
Name Accession Description Interval E-value
Zona_pellucida pfam00100
Zona pellucida-like domain;
44-314 3.37e-43

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 151.61  E-value: 3.37e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631177  44 CGVQAITMKINFCTVLFSGYsETDLALNGRHgDSHCRGFINNNTFPaVVIFIINLStleGCGNnlVVSTIPGVSAYGNat 123
Cdd:pfam00100   1 CTPDTMTVSISKCLLVPSGL-LSSLSLLGGL-DPSCKPVSNTNGSP-AVLFEFPLT---GCGT--TVQVNGTHIIYSN-- 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631177 124 svqvgNISGYIDTPDPPTIISYLPglLYKFSCSYPLEYLVNNTQLASSSAAISVRENNGTFvsTLNLLLYNDSTYNQQLI 203
Cdd:pfam00100  71 -----TLYSSTDLRSGIIRRTITR--RLPFSCSYPRSSLVSLLVVAPPSPVPITVSGSGVF--LVSMDLYYDSSYTSPYS 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631177 204 IPSIGLPLKTKVFAAVQATNL-DGRWNVLMDYCYTTPSGNPNDDIRYDLFL-SCDKDP----QTTVIENGRSQRGRFSFE 277
Cdd:pfam00100 142 PYPVTVLLGDPLYVEVSLLSRtDPNLVLVLDNCWATPSPNPTSSPQYQLIVnGCPNDGdstyPVSSLSNGPSHYVRFSFK 221
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1034631177 278 VFRFVkhkNQKMSTVFLHCVTKLCRADDCPfLMPICS 314
Cdd:pfam00100 222 AFRFV---GSSISQVYLHCSVSVCSSDSNS-CGKSCS 254
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
44-314 9.78e-21

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 90.91  E-value: 9.78e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631177   44 CGVQAITMKINFCTVLFSGYSETDLALngrhGDSHCRGFINNNTfPAVVIFIINLStleGCGNnlVVSTIPGVSAYGNAT 123
Cdd:smart00241   2 CGEDQMVVSVSTDLLFPGGINVKGLTL----GDPSCRPQFTDAT-SAFVSFEVPLN---GCGT--RRQVNPDGIVYSNTL 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631177  124 SVQVGnisgyidtpdPPTIISYLPGLLYKFSCSYPL-EYLVNNTQLASSSAAISVRENNGTFvsTLNLLLYNDSTYNQql 202
Cdd:smart00241  72 VVSPF----------HPGFITRDDRAAYHFQCFYPEnEKVSLNLDVSTIPPTELSSVSEGPL--TCSYRLYKDDSFGS-- 137
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631177  203 IIPSIGLPLKTKVFAAVQATN-LDGRWNVLMDYCYTTPSGNPNDDIRYDLFLS-CDKDP---QTTVIENGRSQRGRFSFE 277
Cdd:smart00241 138 PYQSADYVLGDPVYHEWECDGaDDPPLGLLVDNCYATPGPDPSSGPKYFIIDNgCPVDGyldSTIPYNSNPLHRARFSVK 217
                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1034631177  278 VFRFVKHknqkmSTVFLHCVTKLCRADDCPF-LMPICS 314
Cdd:smart00241 218 VFKFADR-----SLVYFHCQIRLCDKDDGSScDGPACS 250
 
Name Accession Description Interval E-value
Zona_pellucida pfam00100
Zona pellucida-like domain;
44-314 3.37e-43

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 151.61  E-value: 3.37e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631177  44 CGVQAITMKINFCTVLFSGYsETDLALNGRHgDSHCRGFINNNTFPaVVIFIINLStleGCGNnlVVSTIPGVSAYGNat 123
Cdd:pfam00100   1 CTPDTMTVSISKCLLVPSGL-LSSLSLLGGL-DPSCKPVSNTNGSP-AVLFEFPLT---GCGT--TVQVNGTHIIYSN-- 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631177 124 svqvgNISGYIDTPDPPTIISYLPglLYKFSCSYPLEYLVNNTQLASSSAAISVRENNGTFvsTLNLLLYNDSTYNQQLI 203
Cdd:pfam00100  71 -----TLYSSTDLRSGIIRRTITR--RLPFSCSYPRSSLVSLLVVAPPSPVPITVSGSGVF--LVSMDLYYDSSYTSPYS 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631177 204 IPSIGLPLKTKVFAAVQATNL-DGRWNVLMDYCYTTPSGNPNDDIRYDLFL-SCDKDP----QTTVIENGRSQRGRFSFE 277
Cdd:pfam00100 142 PYPVTVLLGDPLYVEVSLLSRtDPNLVLVLDNCWATPSPNPTSSPQYQLIVnGCPNDGdstyPVSSLSNGPSHYVRFSFK 221
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1034631177 278 VFRFVkhkNQKMSTVFLHCVTKLCRADDCPfLMPICS 314
Cdd:pfam00100 222 AFRFV---GSSISQVYLHCSVSVCSSDSNS-CGKSCS 254
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
44-314 9.78e-21

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 90.91  E-value: 9.78e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631177   44 CGVQAITMKINFCTVLFSGYSETDLALngrhGDSHCRGFINNNTfPAVVIFIINLStleGCGNnlVVSTIPGVSAYGNAT 123
Cdd:smart00241   2 CGEDQMVVSVSTDLLFPGGINVKGLTL----GDPSCRPQFTDAT-SAFVSFEVPLN---GCGT--RRQVNPDGIVYSNTL 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631177  124 SVQVGnisgyidtpdPPTIISYLPGLLYKFSCSYPL-EYLVNNTQLASSSAAISVRENNGTFvsTLNLLLYNDSTYNQql 202
Cdd:smart00241  72 VVSPF----------HPGFITRDDRAAYHFQCFYPEnEKVSLNLDVSTIPPTELSSVSEGPL--TCSYRLYKDDSFGS-- 137
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631177  203 IIPSIGLPLKTKVFAAVQATN-LDGRWNVLMDYCYTTPSGNPNDDIRYDLFLS-CDKDP---QTTVIENGRSQRGRFSFE 277
Cdd:smart00241 138 PYQSADYVLGDPVYHEWECDGaDDPPLGLLVDNCYATPGPDPSSGPKYFIIDNgCPVDGyldSTIPYNSNPLHRARFSVK 217
                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1034631177  278 VFRFVKHknqkmSTVFLHCVTKLCRADDCPF-LMPICS 314
Cdd:smart00241 218 VFKFADR-----SLVYFHCQIRLCDKDDGSScDGPACS 250
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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