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Conserved domains on  [gi|1034562021|ref|XP_016857877|]
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DENN domain-containing protein 2D isoform X6 [Homo sapiens]

Protein Classification

DENN and dDENN domain-containing protein( domain architecture ID 10489616)

DENN and dDENN domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 4-153 4.45e-61

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


:

Pssm-ID: 460461  Cd Length: 186  Bit Score: 191.63  E-value: 4.45e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562021   4 IYPFMQG-LREAAFPAPGKTVTLKsfiPDSGTEFISLTRPLDSHL--EHVDFSSLLHCLSFEQILQIFASAVLERKIIFL 80
Cdd:pfam02141  38 IERFIANlLYEVPFPPPGRTQKLK---PLGGTEPILLQRPEDSELplEGVDLHLLFRCLSPENILQLFEAALLERRIIFL 114

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034562021  81 AEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMRFQQEVmDSPMEEVLLVNLCEG 153
Cdd:pfam02141 115 SSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPFIIGVHSRYFDLL-EDPLDDVVLVDLDTG 186
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 192-257 1.76e-13

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 64.23  E-value: 1.76e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034562021  192 NEHVSGPFVQFFVKIVGHYASYIKR---EANGQGHFQERSFCKALtSKTNRRFVKKFVKTQLFSLFIQE 257
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLRElrkEPGPVITFDKESFLKSR-PSSERPFLSKFLETQMFSQFIEE 68
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 4-153 4.45e-61

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 191.63  E-value: 4.45e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562021   4 IYPFMQG-LREAAFPAPGKTVTLKsfiPDSGTEFISLTRPLDSHL--EHVDFSSLLHCLSFEQILQIFASAVLERKIIFL 80
Cdd:pfam02141  38 IERFIANlLYEVPFPPPGRTQKLK---PLGGTEPILLQRPEDSELplEGVDLHLLFRCLSPENILQLFEAALLERRIIFL 114

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034562021  81 AEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMRFQQEVmDSPMEEVLLVNLCEG 153
Cdd:pfam02141 115 SSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPFIIGVHSRYFDLL-EDPLDDVVLVDLDTG 186
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 2-153 2.81e-55

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 177.00  E-value: 2.81e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562021    2 AVIYPFMQGLREAAFPAPGKTVTLKSFIPdsgTEFISLTRPLDSHLEHVDFS--SLLHCLSFEQILQIFASAVLERKIIF 79
Cdd:smart00799  33 NLPLELLISLLLYPVPPPGGSLVLVSLGP---GDLIELQRPLDSSLPLIDFSlhELFECLGVENILQLFAALLLERRIIF 109

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034562021   80 LAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEG 153
Cdd:smart00799 110 TSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGVHSSYFEEVKELPDEDVVVVDLDTG 183
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 192-257 1.76e-13

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 64.23  E-value: 1.76e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034562021  192 NEHVSGPFVQFFVKIVGHYASYIKR---EANGQGHFQERSFCKALtSKTNRRFVKKFVKTQLFSLFIQE 257
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLRElrkEPGPVITFDKESFLKSR-PSSERPFLSKFLETQMFSQFIEE 68
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 224-272 3.20e-10

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 54.51  E-value: 3.20e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1034562021 224 FQERSFCKALtSKTNRRFVKKFVKTQLFSLFIQEAEKSKNPPAGYFQQK 272
Cdd:pfam03455   1 FDKEAFLKSL-PSDSRPFLSQFLETQMFNEFIEERLESSDPSIDLFDEE 48
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 4-153 4.45e-61

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 191.63  E-value: 4.45e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562021   4 IYPFMQG-LREAAFPAPGKTVTLKsfiPDSGTEFISLTRPLDSHL--EHVDFSSLLHCLSFEQILQIFASAVLERKIIFL 80
Cdd:pfam02141  38 IERFIANlLYEVPFPPPGRTQKLK---PLGGTEPILLQRPEDSELplEGVDLHLLFRCLSPENILQLFEAALLERRIIFL 114

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034562021  81 AEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMRFQQEVmDSPMEEVLLVNLCEG 153
Cdd:pfam02141 115 SSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPFIIGVHSRYFDLL-EDPLDDVVLVDLDTG 186
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 2-153 2.81e-55

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 177.00  E-value: 2.81e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562021    2 AVIYPFMQGLREAAFPAPGKTVTLKSFIPdsgTEFISLTRPLDSHLEHVDFS--SLLHCLSFEQILQIFASAVLERKIIF 79
Cdd:smart00799  33 NLPLELLISLLLYPVPPPGGSLVLVSLGP---GDLIELQRPLDSSLPLIDFSlhELFECLGVENILQLFAALLLERRIIF 109

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034562021   80 LAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLCEG 153
Cdd:smart00799 110 TSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGVHSSYFEEVKELPDEDVVVVDLDTG 183
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 192-257 1.76e-13

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 64.23  E-value: 1.76e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034562021  192 NEHVSGPFVQFFVKIVGHYASYIKR---EANGQGHFQERSFCKALtSKTNRRFVKKFVKTQLFSLFIQE 257
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLRElrkEPGPVITFDKESFLKSR-PSSERPFLSKFLETQMFSQFIEE 68
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 224-272 3.20e-10

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 54.51  E-value: 3.20e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1034562021 224 FQERSFCKALtSKTNRRFVKKFVKTQLFSLFIQEAEKSKNPPAGYFQQK 272
Cdd:pfam03455   1 FDKEAFLKSL-PSDSRPFLSQFLETQMFNEFIEERLESSDPSIDLFDEE 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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