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Conserved domains on  [gi|1034557310|ref|XP_016856378|]
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N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 isoform X1 [Homo sapiens]

Protein Classification

dimethylarginine dimethylaminohydrolase family protein( domain architecture ID 1904273)

dimethylarginine dimethylaminohydrolase (DdaH) family protein similar to Pseudomonas aeruginosa N(G),N(G)-dimethylarginine dimethylaminohydrolase that hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DdaH super family cl43535
N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism];
7-183 3.97e-17

N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism];


The actual alignment was detected with superfamily member COG1834:

Pssm-ID: 441439 [Multi-domain]  Cd Length: 264  Bit Score: 76.75  E-value: 3.97e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034557310   7 GQVDMMKEALEKLQLNIVEMKDEnATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFkDYAVSTVPVADG--LHLKSF 84
Cdd:COG1834    91 GEEAAYREWLEELGIPVVRLPEP-GVFEGGDVLLDGDTLLVGYGFRTNRAGIEWLARLL-GYEVVPLELVDPrfLHLDTA 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034557310  85 CSMAGPNLIAI---GSSESAQKALKimqqmsDHRYDKLTVPDD----IAANCiyLNIPNKgHVLLHrtpeeyPESAKVYE 157
Cdd:COG1834   169 FCPLAPGLALVypeAFDPESLALLK------EPGWDLIEVPEEeaawLGCNV--LSLGGR-RVVSP------AGNPRLNA 233

                         170       180
                  ....*....|....*....|....*...
gi 1034557310 158 KLKDHML--IPVSMSELEKVDGLLTCCS 183
Cdd:COG1834   234 ALRAAGFevIEVDLSEFLKGGGGFHCLT 261
 
Name Accession Description Interval E-value
DdaH COG1834
N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism];
7-183 3.97e-17

N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism];


Pssm-ID: 441439 [Multi-domain]  Cd Length: 264  Bit Score: 76.75  E-value: 3.97e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034557310   7 GQVDMMKEALEKLQLNIVEMKDEnATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFkDYAVSTVPVADG--LHLKSF 84
Cdd:COG1834    91 GEEAAYREWLEELGIPVVRLPEP-GVFEGGDVLLDGDTLLVGYGFRTNRAGIEWLARLL-GYEVVPLELVDPrfLHLDTA 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034557310  85 CSMAGPNLIAI---GSSESAQKALKimqqmsDHRYDKLTVPDD----IAANCiyLNIPNKgHVLLHrtpeeyPESAKVYE 157
Cdd:COG1834   169 FCPLAPGLALVypeAFDPESLALLK------EPGWDLIEVPEEeaawLGCNV--LSLGGR-RVVSP------AGNPRLNA 233

                         170       180
                  ....*....|....*....|....*...
gi 1034557310 158 KLKDHML--IPVSMSELEKVDGLLTCCS 183
Cdd:COG1834   234 ALRAAGFevIEVDLSEFLKGGGGFHCLT 261
PRK01388 PRK01388
arginine deiminase; Provisional
 22-87 1.45e-04

arginine deiminase; Provisional


Pssm-ID: 234949  Cd Length: 406  Bit Score: 41.30  E-value: 1.45e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034557310  22 NIVEMKDENATLDGGDVLFTGRE-FFVGLSKRTNQRGAEILADT-FKDYAVSTVPVAD------GLHLKSFCSM 87
Cdd:PRK01388  203 PVWDDRHGNATLEGGDVLVLGKGvVAIGMSERTSPQAIEQLARSlFKKGAAKRVLAVEipksraFMHLDTVFTM 276
 
Name Accession Description Interval E-value
DdaH COG1834
N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism];
7-183 3.97e-17

N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism];


Pssm-ID: 441439 [Multi-domain]  Cd Length: 264  Bit Score: 76.75  E-value: 3.97e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034557310   7 GQVDMMKEALEKLQLNIVEMKDEnATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFkDYAVSTVPVADG--LHLKSF 84
Cdd:COG1834    91 GEEAAYREWLEELGIPVVRLPEP-GVFEGGDVLLDGDTLLVGYGFRTNRAGIEWLARLL-GYEVVPLELVDPrfLHLDTA 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034557310  85 CSMAGPNLIAI---GSSESAQKALKimqqmsDHRYDKLTVPDD----IAANCiyLNIPNKgHVLLHrtpeeyPESAKVYE 157
Cdd:COG1834   169 FCPLAPGLALVypeAFDPESLALLK------EPGWDLIEVPEEeaawLGCNV--LSLGGR-RVVSP------AGNPRLNA 233

                         170       180
                  ....*....|....*....|....*...
gi 1034557310 158 KLKDHML--IPVSMSELEKVDGLLTCCS 183
Cdd:COG1834   234 ALRAAGFevIEVDLSEFLKGGGGFHCLT 261
PRK01388 PRK01388
arginine deiminase; Provisional
 22-87 1.45e-04

arginine deiminase; Provisional


Pssm-ID: 234949  Cd Length: 406  Bit Score: 41.30  E-value: 1.45e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034557310  22 NIVEMKDENATLDGGDVLFTGRE-FFVGLSKRTNQRGAEILADT-FKDYAVSTVPVAD------GLHLKSFCSM 87
Cdd:PRK01388  203 PVWDDRHGNATLEGGDVLVLGKGvVAIGMSERTSPQAIEQLARSlFKKGAAKRVLAVEipksraFMHLDTVFTM 276
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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