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Conserved domains on  [gi|982964220|ref|XP_015315424|]
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zinc finger and SCAN domain-containing protein 26 isoform X1 [Bos taurus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SCAN super family cl42860
leucine rich region;
52-157 4.39e-51

leucine rich region;


The actual alignment was detected with superfamily member smart00431:

Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 169.02  E-value: 4.39e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982964220    52 KRFRQLRYEETTGPREALSRLRELCRQWLQPETHTKEQILELLVLEQFLTILPEELQARLREHHLESGEDAVVFLEDLQL 131
Cdd:smart00431   6 QRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQILELLVLEQFLTILPGELQAWVREHHPESGEEAVTLLEDLER 85

                           90       100
                   ....*....|....*....|....*.
gi 982964220   132 ELGGTGQQEdPNQAKKQEVLMEKTAP 157
Cdd:smart00431  86 ELDEPGQQV-SAHVHGQEVLLEKMVP 110
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
290-469 3.34e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 3.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982964220 290 KAFQRSSHLVRHQKIHLG-EKPYQCKECGKVFSQNAGLLEHLR--IHTGE--KPYLCIH--CGKNFRRSSHLNRHQRIHS 362
Cdd:COG5048  268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982964220 363 QEEPCQCK--ECGKTFSQAL-----LLTHHQRIHSHSRSHQC--NECGKTFSLTSDLIRHHRIHTGEKP--FKCTICQKA 431
Cdd:COG5048  348 SISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKS 427

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 982964220 432 FRLNSHLAQHVRIHNEEKPYKCNECGeAFRQRSGLFQH 469
Cdd:COG5048  428 FNRHYNLIPHKKIHTNHAPLLCSILK-SFRRDLDLSNH 464
 
Name Accession Description Interval E-value
SCAN smart00431
leucine rich region;
52-157 4.39e-51

leucine rich region;


Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 169.02  E-value: 4.39e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982964220    52 KRFRQLRYEETTGPREALSRLRELCRQWLQPETHTKEQILELLVLEQFLTILPEELQARLREHHLESGEDAVVFLEDLQL 131
Cdd:smart00431   6 QRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQILELLVLEQFLTILPGELQAWVREHHPESGEEAVTLLEDLER 85

                           90       100
                   ....*....|....*....|....*.
gi 982964220   132 ELGGTGQQEdPNQAKKQEVLMEKTAP 157
Cdd:smart00431  86 ELDEPGQQV-SAHVHGQEVLLEKMVP 110
SCAN pfam02023
SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found ...
 47-135 1.50e-44

SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.


Pssm-ID: 460417 [Multi-domain]  Cd Length: 89  Bit Score: 151.10  E-value: 1.50e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982964220   47 QEPLCKRFRQLRYEETTGPREALSRLRELCRQWLQPETHTKEQILELLVLEQFLTILPEELQARLREHHLESGEDAVVFL 126
Cdd:pfam02023   1 PEASRQRFRQFCYQEAEGPREALSQLRELCHQWLRPEKHTKEQILELLVLEQFLTILPEEIQSWVREHHPESGEEAVALA 80


                  ....*....
gi 982964220  127 EDLQLELGG 135
Cdd:pfam02023  81 EDLLLERGE 89
SCAN cd07936
SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 ...
 52-130 5.59e-36

SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several vertebrate proteins that contain C2H2 zinc finger motifs, many of which may be transcription factors playing roles in cell survival and differentiation. This protein-interaction domain is able to mediate homo- and hetero-oligomerization of SCAN-containing proteins. Some SCAN-containing proteins, including those of lower vertebrates, do not contain zinc finger motifs. It has been noted that the SCAN domain resembles a domain-swapped version of the C-terminal domain of the HIV capsid protein. This domain model features elements common to the three general groups of SCAN domains (SCAN-A1, SCAN-A2, and SCAN-B). The SCAND1 protein is truncated at the C-terminus with respect to this model, the SCAND2 protein appears to have a truncated central helix.


Pssm-ID: 153421  Cd Length: 85  Bit Score: 128.15  E-value: 5.59e-36
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 982964220  52 KRFRQLRYEETTGPREALSRLRELCRQWLQPETHTKEQILELLVLEQFLTILPEELQARLREHHLESGEDAVVFLEDLQ 130
Cdd:cd07936    6 QRFRAFQYQEASGPREALQRLRELCRQWLRPEIHTKEQILELLVLEQFLIILPPEVQAWVRERKPESGEEAATLAEDLL 84
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
290-469 3.34e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 3.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982964220 290 KAFQRSSHLVRHQKIHLG-EKPYQCKECGKVFSQNAGLLEHLR--IHTGE--KPYLCIH--CGKNFRRSSHLNRHQRIHS 362
Cdd:COG5048  268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982964220 363 QEEPCQCK--ECGKTFSQAL-----LLTHHQRIHSHSRSHQC--NECGKTFSLTSDLIRHHRIHTGEKP--FKCTICQKA 431
Cdd:COG5048  348 SISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKS 427

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 982964220 432 FRLNSHLAQHVRIHNEEKPYKCNECGeAFRQRSGLFQH 469
Cdd:COG5048  428 FNRHYNLIPHKKIHTNHAPLLCSILK-SFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
297-322 1.28e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.28e-04
                          10        20
                  ....*....|....*....|....*.
gi 982964220  297 HLVRHQKIHLGEKPYQCKECGKVFSQ 322
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
SCAN smart00431
leucine rich region;
52-157 4.39e-51

leucine rich region;


Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 169.02  E-value: 4.39e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982964220    52 KRFRQLRYEETTGPREALSRLRELCRQWLQPETHTKEQILELLVLEQFLTILPEELQARLREHHLESGEDAVVFLEDLQL 131
Cdd:smart00431   6 QRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQILELLVLEQFLTILPGELQAWVREHHPESGEEAVTLLEDLER 85

                           90       100
                   ....*....|....*....|....*.
gi 982964220   132 ELGGTGQQEdPNQAKKQEVLMEKTAP 157
Cdd:smart00431  86 ELDEPGQQV-SAHVHGQEVLLEKMVP 110
SCAN pfam02023
SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found ...
 47-135 1.50e-44

SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.


Pssm-ID: 460417 [Multi-domain]  Cd Length: 89  Bit Score: 151.10  E-value: 1.50e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982964220   47 QEPLCKRFRQLRYEETTGPREALSRLRELCRQWLQPETHTKEQILELLVLEQFLTILPEELQARLREHHLESGEDAVVFL 126
Cdd:pfam02023   1 PEASRQRFRQFCYQEAEGPREALSQLRELCHQWLRPEKHTKEQILELLVLEQFLTILPEEIQSWVREHHPESGEEAVALA 80


                  ....*....
gi 982964220  127 EDLQLELGG 135
Cdd:pfam02023  81 EDLLLERGE 89
SCAN cd07936
SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 ...
 52-130 5.59e-36

SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several vertebrate proteins that contain C2H2 zinc finger motifs, many of which may be transcription factors playing roles in cell survival and differentiation. This protein-interaction domain is able to mediate homo- and hetero-oligomerization of SCAN-containing proteins. Some SCAN-containing proteins, including those of lower vertebrates, do not contain zinc finger motifs. It has been noted that the SCAN domain resembles a domain-swapped version of the C-terminal domain of the HIV capsid protein. This domain model features elements common to the three general groups of SCAN domains (SCAN-A1, SCAN-A2, and SCAN-B). The SCAND1 protein is truncated at the C-terminus with respect to this model, the SCAND2 protein appears to have a truncated central helix.


Pssm-ID: 153421  Cd Length: 85  Bit Score: 128.15  E-value: 5.59e-36
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 982964220  52 KRFRQLRYEETTGPREALSRLRELCRQWLQPETHTKEQILELLVLEQFLTILPEELQARLREHHLESGEDAVVFLEDLQ 130
Cdd:cd07936    6 QRFRAFQYQEASGPREALQRLRELCRQWLRPEIHTKEQILELLVLEQFLIILPPEVQAWVRERKPESGEEAATLAEDLL 84
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
290-469 3.34e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 3.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982964220 290 KAFQRSSHLVRHQKIHLG-EKPYQCKECGKVFSQNAGLLEHLR--IHTGE--KPYLCIH--CGKNFRRSSHLNRHQRIHS 362
Cdd:COG5048  268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982964220 363 QEEPCQCK--ECGKTFSQAL-----LLTHHQRIHSHSRSHQC--NECGKTFSLTSDLIRHHRIHTGEKP--FKCTICQKA 431
Cdd:COG5048  348 SISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKS 427

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 982964220 432 FRLNSHLAQHVRIHNEEKPYKCNECGeAFRQRSGLFQH 469
Cdd:COG5048  428 FNRHYNLIPHKKIHTNHAPLLCSILK-SFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
243-441 2.70e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 2.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982964220 243 QHSDLIKHESSHRKEKLCEAEVC-QSLSLPGHQKICSREKG-----HQCHECGKAFQRSSHLVRHQ--KIHLGE--KPYQ 312
Cdd:COG5048  244 SPSSLSSSDSSSSASESPRSSLPtASSQSSSPNESDSSSEKgfslpIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFS 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982964220 313 CKE--CGKVFSQNAGLLEHLRIHTGEKPYLCI--HCGKNFRRSSHLNRHQRIHSQEEPCQCKE-------CGKTFSQALL 381
Cdd:COG5048  324 CPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKDLKNDKKsetlsnsCIRNFKRDSN 403

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 982964220 382 LTHHQRIHSHSRSHQCN--ECGKTFSLTSDLIRHHRIHTGEKPFkCTICQKAFRLNSHLAQH 441
Cdd:COG5048  404 LSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL-LCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
239-450 1.21e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 1.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982964220 239 QAFFQHSDLIKHESSHRKEKLCEAEVCQSLSLPGhqkICSREKGHQCHECGKAFQRSSHLVRHQKIHL-GEKPYQCKECG 317
Cdd:COG5048  163 QSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSI---PSSSENSPLSSSYSIPSSSSDQNLENSSSSLpLTTNSQLSPKS 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982964220 318 KVFSQNAGLLEHLRIHTGEKPYLCIHCGKNFRRSSHLNRHQRIHS-QEEPCQCKECGKTFSQALLLTHHQRIHSHS---- 392
Cdd:COG5048  240 LLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKgFSLPIKSKQCNISFSRSSPLTRHLRSVNHSgesl 319

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 982964220 393 RSHQCNE--CGKTFSLTSDLIRHHRIHTGEKPFKC--TICQKAFRLNSHLAQHVRIHNEEKP 450
Cdd:COG5048  320 KPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKDL 381
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
283-456 5.85e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 5.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982964220 283 HQCHECGKAFQRSSHLVRHQKIHLGEKPYQC--KECGKVFSQNAGLLEHLRIHTGEKPYLCIHCGK--NFRRSSHLNRHQ 358
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPlsNSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982964220 359 RIHSQeEPCQCKECGKTFSQALLLTHHQRIHSHSRS---HQCNECGKTFSLTSDLI-------------------RHHRI 416
Cdd:COG5048  114 SSNSN-DNNLLSSHSLPPSSRDPQLPDLLSISNLRNnplPGNNSSSVNTPQSNSLHpplpanslskdpssnlsllISSNV 192

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 982964220 417 HTGEKPFKCTICQKAFRLNSHLAQHVRIHNEEKPYKCNEC 456
Cdd:COG5048  193 STSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN 232
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
337-408 8.82e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 8.82e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 982964220 337 KPYLCIHCGKNFRRSSHLNRHQRIHSQEEPCQC--KECGKTFSQALLLTHHQRIHSHSRSH-QCNECGKTFSLTS 408
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKAS 106
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
309-363 1.27e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.27e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 982964220 309 KPYQCKECGKVFSQNAGLLEHLRIHTGEKPYLCIH--CGKNFRRSSHLNRHQRIHSQ 363
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHN 88
zf-H2C2_2 pfam13465
Zinc-finger double domain;
297-322 1.28e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.28e-04
                          10        20
                  ....*....|....*....|....*.
gi 982964220  297 HLVRHQKIHLGEKPYQCKECGKVFSQ 322
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
393-454 7.14e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 7.14e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 982964220 393 RSHQCNECGKTFSLTSDLIRHHRIHTGEKPFKCT--ICQKAFRLNSHLAQHVRIHNEEKPYKCN 454
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS 95
zf-H2C2_2 pfam13465
Zinc-finger double domain;
409-432 7.85e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 7.85e-04
                          10        20
                  ....*....|....*....|....
gi 982964220  409 DLIRHHRIHTGEKPFKCTICQKAF 432
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
437-462 1.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.09e-03
                          10        20
                  ....*....|....*....|....*.
gi 982964220  437 HLAQHVRIHNEEKPYKCNECGEAFRQ 462
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 283-305 1.70e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.70e-03
                          10        20
                  ....*....|....*....|...
gi 982964220  283 HQCHECGKAFQRSSHLVRHQKIH 305
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
326-350 2.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.08e-03
                          10        20
                  ....*....|....*....|....*
gi 982964220  326 LLEHLRIHTGEKPYLCIHCGKNFRR 350
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
421-476 2.15e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 2.15e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 982964220 421 KPFKCTICQKAFRLNSHLAQHVRIHNEEKPYKCNECGEAFRQRSG--LFQHQRYHHKN 476
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNN 89
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 419-474 2.33e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 2.33e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 982964220 419 GEKPFKCTI--CQKAF---------RLNSHLAQ----------HVRIHNEEKPYKCNECGEAFRQRSGLFQHQRYHH 474
Cdd:COG5189  346 DGKPYKCPVegCNKKYknqnglkyhMLHGHQNQklhenpspekMNIFSAKDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 311-333 6.52e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 6.52e-03
                          10        20
                  ....*....|....*....|...
gi 982964220  311 YQCKECGKVFSQNAGLLEHLRIH 333
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 451-473 9.76e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.43  E-value: 9.76e-03
                          10        20
                  ....*....|....*....|...
gi 982964220  451 YKCNECGEAFRQRSGLFQHQRYH 473
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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