NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|971428935|ref|XP_015152452|]
View 

espin isoform X4 [Gallus gallus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
52-324 3.71e-40

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 150.10  E-value: 3.71e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935  52 LRYLAAEAALRGDARARNGATPAHDAAATGNLACLQWLLTQGGCGVQDTDNSGATILHLAARFGHHEVIEWLLRFGGSDP 131
Cdd:COG0666    1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 132 TAATDTGALPVHYAAAKGDFPSLRLLLGHcPSTLSAQTKTGATPLYLACQEGHLEIIQYLVkDCGADPHVRANDGMTPLH 211
Cdd:COG0666   81 NAKDDGGNTLLHAAARNGDLEIVKLLLEA-GADVNARDKDGETPLHLAAYNGNLEIVKLLL-EAGADVNAQDNDGNTPLH 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 212 AAAQMGHNTVIVWLMSFTtVSLSERDDDGATAMHFAASRGHAKVLSWLLLHGGEITA-DGWGGTPLHDAAENGELECCQI 290
Cdd:COG0666  159 LAAANGNLEIVKLLLEAG-ADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAkDNDGKTALDLAAENGNLEIVKL 237

                        250       260       270
                 ....*....|....*....|....*....|....
gi 971428935 291 LVVNGADLSIRDQDGYTAADLADYNGHIHCAKYL 324
Cdd:COG0666  238 LLEAGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
Ank_2 pfam12796
Ankyrin repeats (3 copies);
8-93 2.60e-12

Ankyrin repeats (3 copies);


:

Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.21  E-value: 2.60e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935    8 QAARQGDVEALRGLRAAGLlRPGLRDALGASPAHHAARAGRLACLRYLAAEAALRGDArarNGATPAHDAAATGNLACLQ 87
Cdd:pfam12796   3 LAAKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD---NGRTALHYAARSGHLEIVK 78


                  ....*.
gi 971428935   88 WLLTQG 93
Cdd:pfam12796  79 LLLEKG 84
WH2 pfam02205
WH2 motif; The WH2 motif (for Wiskott Aldrich syndrome homology region 2) has been shown in ...
 624-649 7.96e-03

WH2 motif; The WH2 motif (for Wiskott Aldrich syndrome homology region 2) has been shown in WASP and Scar1 (mammalian homolog) to be the region that interacts with actin.


:

Pssm-ID: 460490  Cd Length: 28  Bit Score: 34.40  E-value: 7.96e-03
                          10        20
                  ....*....|....*....|....*.
gi 971428935  624 PTGDNSELLAEIKAGKSLKPTPQSKG 649
Cdd:pfam02205   1 GGGGRGALLADIRAGKKLKKVEETND 26
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
52-324 3.71e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 150.10  E-value: 3.71e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935  52 LRYLAAEAALRGDARARNGATPAHDAAATGNLACLQWLLTQGGCGVQDTDNSGATILHLAARFGHHEVIEWLLRFGGSDP 131
Cdd:COG0666    1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 132 TAATDTGALPVHYAAAKGDFPSLRLLLGHcPSTLSAQTKTGATPLYLACQEGHLEIIQYLVkDCGADPHVRANDGMTPLH 211
Cdd:COG0666   81 NAKDDGGNTLLHAAARNGDLEIVKLLLEA-GADVNARDKDGETPLHLAAYNGNLEIVKLLL-EAGADVNAQDNDGNTPLH 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 212 AAAQMGHNTVIVWLMSFTtVSLSERDDDGATAMHFAASRGHAKVLSWLLLHGGEITA-DGWGGTPLHDAAENGELECCQI 290
Cdd:COG0666  159 LAAANGNLEIVKLLLEAG-ADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAkDNDGKTALDLAAENGNLEIVKL 237

                        250       260       270
                 ....*....|....*....|....*....|....
gi 971428935 291 LVVNGADLSIRDQDGYTAADLADYNGHIHCAKYL 324
Cdd:COG0666  238 LLEAGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
Ank_2 pfam12796
Ankyrin repeats (3 copies);
176-268 1.55e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 86.71  E-value: 1.55e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935  176 LYLACQEGHLEIIQYLVKdCGADPHVRANDGMTPLHAAAQMGHNTVIVWLMSFTTVslsERDDDGATAMHFAASRGHAKV 255
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV---NLKDNGRTALHYAARSGHLEI 76

                          90
                  ....*....|...
gi 971428935  256 LSWLLLHGGEITA 268
Cdd:pfam12796  77 VKLLLEKGADINV 89
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 72-312 3.55e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 78.85  E-value: 3.55e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935  72 TPAHDAAATGNLACLQwLLTQGGCGVQDTDNSGATILHLAARFGHHEVIEWLLRFGgsdptaaTDTGALPV--------- 142
Cdd:PHA02874  37 TPLIDAIRSGDAKIVE-LFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNG-------VDTSILPIpciekdmik 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 143 --------------------HYAAAKGDFPSLRLLLGHcPSTLSAQTKTGATPLYLACQEGHLEIIQYLVKDcGADPHVR 202
Cdd:PHA02874 109 tildcgidvnikdaelktflHYAIKKGDLESIKMLFEY-GADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEK-GAYANVK 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 203 ANDGMTPLHAAAQMGHNTVIVWLMSFTTvSLSERDDDGATAMHFAASrgHAKVLSWLLLHGGEIT-ADGWGGTPLHDAAE 281
Cdd:PHA02874 187 DNNGESPLHNAAEYGDYACIKLLIDHGN-HIMNKCKNGFTPLHNAII--HNRSAIELLINNASINdQDIDGSTPLHHAIN 263

                        250       260       270
                 ....*....|....*....|....*....|..
gi 971428935 282 NG-ELECCQILVVNGADLSIRDQDGYTAADLA 312
Cdd:PHA02874 264 PPcDIDIIDILLYHKADISIKDNKGENPIDTA 295
Ank_2 pfam12796
Ankyrin repeats (3 copies);
8-93 2.60e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.21  E-value: 2.60e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935    8 QAARQGDVEALRGLRAAGLlRPGLRDALGASPAHHAARAGRLACLRYLAAEAALRGDArarNGATPAHDAAATGNLACLQ 87
Cdd:pfam12796   3 LAAKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD---NGRTALHYAARSGHLEIVK 78


                  ....*.
gi 971428935   88 WLLTQG 93
Cdd:pfam12796  79 LLLEKG 84
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 7-193 1.74e-08

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 58.10  E-value: 1.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935   7 LQAARQGDVEALRGLRAAGLLRPGLRDALGASPAHHAARAGRLAclrylAAEAALRGDARARN---------GATPAHDA 77
Cdd:cd22192   22 LLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLE-----AAVVLMEAAPELVNepmtsdlyqGETALHIA 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935  78 AATGNLACLQWLLTQGGcgvqDTDNSGAT-----------------ILHLAARFGHHEVIEWLLRfGGSDPTAATDTGAL 140
Cdd:cd22192   97 VVNQNLNLVRELIARGA----DVVSPRATgtffrpgpknliyygehPLSFAACVGNEEIVRLLIE-HGADIRAQDSLGNT 171

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 971428935 141 PVH---------YAAAKGDF--PSLRLLLGHCPSTLsaQTKTGATPLYLACQEGHLEIIQYLVK 193
Cdd:cd22192  172 VLHilvlqpnktFACQMYDLilSYDKEDDLQPLDLV--PNNQGLTPFKLAAKEGNIVMFQHLVQ 233
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 172-201 2.88e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.72  E-value: 2.88e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 971428935   172 GATPLYLACQEGHLEIIQYLVkDCGADPHV 201
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLL-DKGADINA 30
WH2 pfam02205
WH2 motif; The WH2 motif (for Wiskott Aldrich syndrome homology region 2) has been shown in ...
 624-649 7.96e-03

WH2 motif; The WH2 motif (for Wiskott Aldrich syndrome homology region 2) has been shown in WASP and Scar1 (mammalian homolog) to be the region that interacts with actin.


Pssm-ID: 460490  Cd Length: 28  Bit Score: 34.40  E-value: 7.96e-03
                          10        20
                  ....*....|....*....|....*.
gi 971428935  624 PTGDNSELLAEIKAGKSLKPTPQSKG 649
Cdd:pfam02205   1 GGGGRGALLADIRAGKKLKKVEETND 26
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
52-324 3.71e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 150.10  E-value: 3.71e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935  52 LRYLAAEAALRGDARARNGATPAHDAAATGNLACLQWLLTQGGCGVQDTDNSGATILHLAARFGHHEVIEWLLRFGGSDP 131
Cdd:COG0666    1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 132 TAATDTGALPVHYAAAKGDFPSLRLLLGHcPSTLSAQTKTGATPLYLACQEGHLEIIQYLVkDCGADPHVRANDGMTPLH 211
Cdd:COG0666   81 NAKDDGGNTLLHAAARNGDLEIVKLLLEA-GADVNARDKDGETPLHLAAYNGNLEIVKLLL-EAGADVNAQDNDGNTPLH 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 212 AAAQMGHNTVIVWLMSFTtVSLSERDDDGATAMHFAASRGHAKVLSWLLLHGGEITA-DGWGGTPLHDAAENGELECCQI 290
Cdd:COG0666  159 LAAANGNLEIVKLLLEAG-ADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAkDNDGKTALDLAAENGNLEIVKL 237

                        250       260       270
                 ....*....|....*....|....*....|....
gi 971428935 291 LVVNGADLSIRDQDGYTAADLADYNGHIHCAKYL 324
Cdd:COG0666  238 LLEAGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
6-269 6.70e-38

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 143.56  E-value: 6.70e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935   6 ALQAARQGDVEALRGLRAAGLLRPGLRDALGASPAHHAARAGRLACLRYLAAEAALRGDARARNGATPAHDAAATGNLAC 85
Cdd:COG0666   23 LLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEI 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935  86 LQWLLTQGGcGVQDTDNSGATILHLAARFGHHEVIEWLLRFGGsDPTAATDTGALPVHYAAAKGDFPSLRLLLGHCPStL 165
Cdd:COG0666  103 VKLLLEAGA-DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD-V 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 166 SAQTKTGATPLYLACQEGHLEIIQYLVkDCGADPHVRANDGMTPLHAAAQMGHNTVIVWLMSFTTVsLSERDDDGATAMH 245
Cdd:COG0666  180 NARDNDGETPLHLAAENGHLEIVKLLL-EAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGAD-LNAKDKDGLTALL 257

                        250       260
                 ....*....|....*....|....
gi 971428935 246 FAASRGHAKVLSWLLLHGGEITAD 269
Cdd:COG0666  258 LAAAAGAALIVKLLLLALLLLAAA 281
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
101-325 1.11e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.79  E-value: 1.11e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 101 DNSGATILHLAARFGHHEVIEWLLRFGGSDPTAATDTGALPVHYAAAKGDFPSLRLLLGHCPSTLSAQTKTGATPLYLAC 180
Cdd:COG0666   16 LLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 181 QEGHLEIIQYLVKDcGADPHVRANDGMTPLHAAAQMGHNTVIVWLMSFTtVSLSERDDDGATAMHFAASRGHAKVLSWLL 260
Cdd:COG0666   96 RNGDLEIVKLLLEA-GADVNARDKDGETPLHLAAYNGNLEIVKLLLEAG-ADVNAQDNDGNTPLHLAAANGNLEIVKLLL 173

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 971428935 261 LHGGEITA-DGWGGTPLHDAAENGELECCQILVVNGADLSIRDQDGYTAADLADYNGHIHCAKYLR 325
Cdd:COG0666  174 EAGADVNArDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLL 239
Ank_2 pfam12796
Ankyrin repeats (3 copies);
176-268 1.55e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 86.71  E-value: 1.55e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935  176 LYLACQEGHLEIIQYLVKdCGADPHVRANDGMTPLHAAAQMGHNTVIVWLMSFTTVslsERDDDGATAMHFAASRGHAKV 255
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLE-NGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV---NLKDNGRTALHYAARSGHLEI 76

                          90
                  ....*....|...
gi 971428935  256 LSWLLLHGGEITA 268
Cdd:pfam12796  77 VKLLLEKGADINV 89
Ank_2 pfam12796
Ankyrin repeats (3 copies);
108-202 8.20e-19

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 81.70  E-value: 8.20e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935  108 LHLAARFGHHEVIEWLLRFGgSDPTAATDTGALPVHYAAAKGDFPSLRLLLGHCPSTLSAQtktGATPLYLACQEGHLEI 187
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDN---GRTALHYAARSGHLEI 76

                          90
                  ....*....|....*
gi 971428935  188 IQYLVkDCGADPHVR 202
Cdd:pfam12796  77 VKLLL-EKGADINVK 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
210-302 1.11e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 81.32  E-value: 1.11e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935  210 LHAAAQMGHNTVIVWLMSFTtVSLSERDDDGATAMHFAASRGHAKVLSWLLLHG-GEITADGWggTPLHDAAENGELECC 288
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAdVNLKDNGR--TALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 971428935  289 QILVVNGADLSIRD 302
Cdd:pfam12796  78 KLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
143-227 6.51e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 73.61  E-value: 6.51e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935  143 HYAAAKGDFPSLRLLLgHCPSTLSAQTKTGATPLYLACQEGHLEIIQYLVKDCGADphvRANDGMTPLHAAAQMGHNTVI 222
Cdd:pfam12796   2 HLAAKNGNLELVKLLL-ENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN---LKDNGRTALHYAARSGHLEIV 77


                  ....*
gi 971428935  223 VWLMS 227
Cdd:pfam12796  78 KLLLE 82
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 72-312 3.55e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 78.85  E-value: 3.55e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935  72 TPAHDAAATGNLACLQwLLTQGGCGVQDTDNSGATILHLAARFGHHEVIEWLLRFGgsdptaaTDTGALPV--------- 142
Cdd:PHA02874  37 TPLIDAIRSGDAKIVE-LFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNG-------VDTSILPIpciekdmik 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 143 --------------------HYAAAKGDFPSLRLLLGHcPSTLSAQTKTGATPLYLACQEGHLEIIQYLVKDcGADPHVR 202
Cdd:PHA02874 109 tildcgidvnikdaelktflHYAIKKGDLESIKMLFEY-GADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEK-GAYANVK 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 203 ANDGMTPLHAAAQMGHNTVIVWLMSFTTvSLSERDDDGATAMHFAASrgHAKVLSWLLLHGGEIT-ADGWGGTPLHDAAE 281
Cdd:PHA02874 187 DNNGESPLHNAAEYGDYACIKLLIDHGN-HIMNKCKNGFTPLHNAII--HNRSAIELLINNASINdQDIDGSTPLHHAIN 263

                        250       260       270
                 ....*....|....*....|....*....|..
gi 971428935 282 NG-ELECCQILVVNGADLSIRDQDGYTAADLA 312
Cdd:PHA02874 264 PPcDIDIIDILLYHKADISIKDNKGENPIDTA 295
PHA03095 PHA03095
ankyrin-like protein; Provisional
 89-354 1.30e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 77.37  E-value: 1.30e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935  89 LLTQGGcGVQDTDNSGATILHLAARFGHH---EVIEWLLRfGGSDPTAATDTGALPVH-YAAAKGDFPSLRLLLGHCPST 164
Cdd:PHA03095  33 LLAAGA-DVNFRGEYGKTPLHLYLHYSSEkvkDIVRLLLE-AGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGADV 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 165 LsAQTKTGATPL--YLACQEGHLEIIQYLVKDcGADPHVRANDGMTPLHAAAQMGHNTV-IVWLMSFTTVSLSERDDDGA 241
Cdd:PHA03095 111 N-AKDKVGRTPLhvYLSGFNINPKVIRLLLRK-GADVNALDLYGMTPLAVLLKSRNANVeLLRLLIDAGADVYAVDDRFR 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 242 TAMH-FAAS-RGHAKVLSWLLLHGGEITA-DGWGGTPLHDAAENGelECCQILVVN----GADLSIRDQDGYTAADLAD- 313
Cdd:PHA03095 189 SLLHhHLQSfKPRARIVRELIRAGCDPAAtDMLGNTPLHSMATGS--SCKRSLVLPlliaGISINARNRYGQTPLHYAAv 266

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 971428935 314 YNGHIHCAKYLRTVENMSVEhrvlsrdpSADGECrqPDSGM 354
Cdd:PHA03095 267 FNNPRACRRLIALGADINAV--------SSDGNT--PLSLM 297
Ank_2 pfam12796
Ankyrin repeats (3 copies);
244-324 7.78e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.83  E-value: 7.78e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935  244 MHFAASRGHAKVLSWLLLHGGEITA-DGWGGTPLHDAAENGELECCQILVvNGADLSIRDqDGYTAADLADYNGHIHCAK 322
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLqDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ..
gi 971428935  323 YL 324
Cdd:pfam12796  79 LL 80
Ank_2 pfam12796
Ankyrin repeats (3 copies);
41-124 2.32e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.29  E-value: 2.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935   41 HHAARAGRLACLRYLAAEAAlRGDARARNGATPAHDAAATGNLACLQWLLTQggcGVQDTDNSGATILHLAARFGHHEVI 120
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKDNGRTALHYAARSGHLEIV 77


                  ....
gi 971428935  121 EWLL 124
Cdd:pfam12796  78 KLLL 81
PHA03095 PHA03095
ankyrin-like protein; Provisional
 14-344 6.51e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 71.98  E-value: 6.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935  14 DVEALRGLRAAGllrPGL--RDALGASPAH---HAARAGRLACLRYLAaEAALRGDARARNGATPAHDAAATGNLACLQW 88
Cdd:PHA03095  26 TVEEVRRLLAAG---ADVnfRGEYGKTPLHlylHYSSEKVKDIVRLLL-EAGADVNAPERCGFTPLHLYLYNATTLDVIK 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935  89 LLTQGGCGVQDTDNSGATILH--LAARFGHHEVIEWLLRFGgSDPTAATDTGALPVHyaaakgdfpslrLLLGhcpstls 166
Cdd:PHA03095 102 LLIKAGADVNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKG-ADVNALDLYGMTPLA------------VLLK------- 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 167 aqtKTGATPlylacqeghlEIIQYLVkDCGADPHVRANDGMTPLHAAAQMGH-NTVIVWLMSFTTVSLSERDDDGATAMH 245
Cdd:PHA03095 162 ---SRNANV----------ELLRLLI-DAGADVYAVDDRFRSLLHHHLQSFKpRARIVRELIRAGCDPAATDMLGNTPLH 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 246 FAA--SRGHAKVLSWLLLHGGEITA-DGWGGTPLHDAAENGELECCQILVVNGADLSIRDQDGYTAADLADYNGHIHCAK 322
Cdd:PHA03095 228 SMAtgSSCKRSLVLPLLIAGISINArNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVR 307

                        330       340
                 ....*....|....*....|..
gi 971428935 323 ylrtvenmsvehRVLSRDPSAD 344
Cdd:PHA03095 308 ------------AALAKNPSAE 317
Ank_2 pfam12796
Ankyrin repeats (3 copies);
8-93 2.60e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.21  E-value: 2.60e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935    8 QAARQGDVEALRGLRAAGLlRPGLRDALGASPAHHAARAGRLACLRYLAAEAALRGDArarNGATPAHDAAATGNLACLQ 87
Cdd:pfam12796   3 LAAKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD---NGRTALHYAARSGHLEIVK 78


                  ....*.
gi 971428935   88 WLLTQG 93
Cdd:pfam12796  79 LLLEKG 84
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 63-223 6.38e-11

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 66.04  E-value: 6.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935  63 GDARARngaTPAHDAAATGNLACLQWLLTQGgCGVQDTDNSGATILHLAARFGHHEVIEWLLRFGG-SDPTAATDTGALp 141
Cdd:PLN03192 554 GDSKGR---TPLHIAASKGYEDCVLVLLKHA-CNVHIRDANGNTALWNAISAKHHKIFRILYHFASiSDPHAAGDLLCT- 628

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 142 vhyAAAKGDFPSLRLLLGHcPSTLSAQTKTGATPLYLACQEGHLEIIQYLVKDcGAD-PHVRANDGMTP-----LHAAAQ 215
Cdd:PLN03192 629 ---AAKRNDLTAMKELLKQ-GLNVDSEDHQGATALQVAMAEDHVDMVRLLIMN-GADvDKANTDDDFSPtelreLLQKRE 703


                 ....*...
gi 971428935 216 MGHNTVIV 223
Cdd:PLN03192 704 LGHSITIV 711
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 196-324 6.77e-11

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 66.04  E-value: 6.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 196 GADPHVRANDGMTPLHAAAQMGH-NTVIVWLMSFTTVSLseRDDDGATAMHFAASRGHAKVLsWLLLHGGEITADGWGGT 274
Cdd:PLN03192 548 KLDPDIGDSKGRTPLHIAASKGYeDCVLVLLKHACNVHI--RDANGNTALWNAISAKHHKIF-RILYHFASISDPHAAGD 624

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 971428935 275 PLHDAAENGELECCQILVVNGADLSIRDQDGYTAADLADYNGHIHCAKYL 324
Cdd:PLN03192 625 LLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLL 674
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 76-309 8.49e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 65.01  E-value: 8.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935  76 DAAATGNLACLQWLLTQGgCGVQDTDNSGATILHLAARFGHHEVIEWLLRFGGSDPTAATDTGAlPVHYAAAKGDFPSLR 155
Cdd:PHA02875   8 DAILFGELDIARRLLDIG-INPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIES-ELHDAVEEGDVKAVE 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 156 LLLGHCPSTLSAQTKTGATPLYLACQEGHLEIIQYLVKDcGADPHVRANDGMTPLHAAAQMGHNTVIVWLMSfttvslse 235
Cdd:PHA02875  86 ELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIAR-GADPDIPNTDKFSPLHLAVMMGDIKGIELLID-------- 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 971428935 236 rdddgatamhfaasrgHAKVLSwlllhggeiTADGWGGTPLHDAAENGELECCQILVVNGADLSIRDQDGYTAA 309
Cdd:PHA02875 157 ----------------HKACLD---------IEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAA 205
Ank_4 pfam13637
Ankyrin repeats (many copies);
206-260 1.99e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 56.90  E-value: 1.99e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 971428935  206 GMTPLHAAAQMGHNTVIVWLMSFTtVSLSERDDDGATAMHFAASRGHAKVLSWLL 260
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKG-ADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_2 pfam12796
Ankyrin repeats (3 copies);
276-341 1.16e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.89  E-value: 1.16e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 971428935  276 LHDAAENGELECCQILVVNGADLSIRDQDGYTAADLADYNGHIHCAKYLrtVENMSVEHRVLSRDP 341
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLL--LEHADVNLKDNGRTA 64
Ank_4 pfam13637
Ankyrin repeats (many copies);
72-124 1.55e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.20  E-value: 1.55e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 971428935   72 TPAHDAAATGNLACLQWLLtQGGCGVQDTDNSGATILHLAARFGHHEVIEWLL 124
Cdd:pfam13637   3 TALHAAAASGHLELLRLLL-EKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
272-324 6.42e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 52.66  E-value: 6.42e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 971428935  272 GGTPLHDAAENGELECCQILVVNGADLSIRDQDGYTAADLADYNGHIHCAKYL 324
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 88-214 6.61e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 58.91  E-value: 6.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935  88 WLLTQGGCGVQDTDNSGATILHLAA--RFGHHEVIEWLLRFGgSDPTAATDTGALPVHYAAA--KGDFPSLRLLLGH--- 160
Cdd:PHA03100  90 KLLLEYGANVNAPDNNGITPLLYAIskKSNSYSIVEYLLDNG-ANVNIKNSDGENLLHLYLEsnKIDLKILKLLIDKgvd 168

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 971428935 161 --------------CPstLSAQTKTGATPLYLACQEGHLEIIQYLVkDCGADPHVRANDGMTPLHAAA 214
Cdd:PHA03100 169 inaknrvnyllsygVP--INIKDVYGFTPLHYAVYNNNPEFVKYLL-DLGANPNLVNKYGDTPLHIAI 233
Ank_4 pfam13637
Ankyrin repeats (many copies);
174-225 1.29e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.51  E-value: 1.29e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 971428935  174 TPLYLACQEGHLEIIQYLVKDcGADPHVRANDGMTPLHAAAQMGHNTVIVWL 225
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEK-GADINAVDGNGETALHFAASNGNVEVLKLL 53
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 7-193 1.74e-08

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 58.10  E-value: 1.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935   7 LQAARQGDVEALRGLRAAGLLRPGLRDALGASPAHHAARAGRLAclrylAAEAALRGDARARN---------GATPAHDA 77
Cdd:cd22192   22 LLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLE-----AAVVLMEAAPELVNepmtsdlyqGETALHIA 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935  78 AATGNLACLQWLLTQGGcgvqDTDNSGAT-----------------ILHLAARFGHHEVIEWLLRfGGSDPTAATDTGAL 140
Cdd:cd22192   97 VVNQNLNLVRELIARGA----DVVSPRATgtffrpgpknliyygehPLSFAACVGNEEIVRLLIE-HGADIRAQDSLGNT 171

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 971428935 141 PVH---------YAAAKGDF--PSLRLLLGHCPSTLsaQTKTGATPLYLACQEGHLEIIQYLVK 193
Cdd:cd22192  172 VLHilvlqpnktFACQMYDLilSYDKEDDLQPLDLV--PNNQGLTPFKLAAKEGNIVMFQHLVQ 233
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 55-303 1.96e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 58.15  E-value: 1.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935  55 LAAEAALRG--DARARN--GATPAHDAAATGNLACLQWLLTQGGcGVQDTDNSGATILHLAARFGHHEVIE--------- 121
Cdd:PHA02876 159 LIAEMLLEGgaDVNAKDiyCITPIHYAAERGNAKMVNLLLSYGA-DVNIIALDDLSVLECAVDSKNIDTIKaiidnrsni 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 122 -------------------WLLRFGGSDPTAATDTGALPVHYAAAKgdfPSLRLLLghcPSTL------SAQTKTGATPL 176
Cdd:PHA02876 238 nkndlsllkairnedletsLLLYDAGFSVNSIDDCKNTPLHHASQA---PSLSRLV---PKLLergadvNAKNIKGETPL 311

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 177 YLACQEGH-LEIIQYLVKdCGADphVRANDGM--TPLHAAAQMGHNTVIVWLMSFTTVSLSERDDDGATAMHFAASRGHA 253
Cdd:PHA02876 312 YLMAKNGYdTENIRTLIM-LGAD--VNAADRLyiTPLHQASTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNV 388

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 254 KVLSWLLLHGGEITA-----------------------------------DGWGGTPLHDAAENG-ELECCQILVVNGAD 297
Cdd:PHA02876 389 VIINTLLDYGADIEAlsqkigtalhfalcgtnpymsvktlidrganvnskNKDLSTPLHYACKKNcKLDVIEMLLDNGAD 468


                 ....*....
gi 971428935 298 ---LSIRDQ 303
Cdd:PHA02876 469 vnaINIQNQ 477
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 174-324 3.66e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 56.60  E-value: 3.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 174 TPLYLACQEGHLEIIQYLVKDcGADPHVRANDGMTPLHAAAQMGHNTV----IVWLMSFTTVSLSERDDDGATAMHFAAS 249
Cdd:PHA03100  37 LPLYLAKEARNIDVVKILLDN-GADINSSTKNNSTPLHYLSNIKYNLTdvkeIVKLLLEYGANVNAPDNNGITPLLYAIS 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 250 R--GHAKVLSWLLLHGGEITAD-GWGGTPLHDAAENG--ELECCQILVVNGADLS----------------IRDQDGYTA 308
Cdd:PHA03100 116 KksNSYSIVEYLLDNGANVNIKnSDGENLLHLYLESNkiDLKILKLLIDKGVDINaknrvnyllsygvpinIKDVYGFTP 195

                        170
                 ....*....|....*.
gi 971428935 309 ADLADYNGHIHCAKYL 324
Cdd:PHA03100 196 LHYAVYNNNPEFVKYL 211
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 72-251 5.26e-08

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 56.56  E-value: 5.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935  72 TPAHDAAATGNLACLQWLLTQGGCGVQDTDNSGATILHLAARFGHHEVIEWLLRfggSDP-------TAATDTGALPVHY 144
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLME---AAPelvnepmTSDLYQGETALHI 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 145 AAAKGDFPSLRLLLGHCPSTLSAQ-TKT------------GATPL-YLACQeGHLEIIQYLVKDcGADPHVRANDGMTPL 210
Cdd:cd22192   96 AVVNQNLNLVRELIARGADVVSPRaTGTffrpgpknliyyGEHPLsFAACV-GNEEIVRLLIEH-GADIRAQDSLGNTVL 173

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 971428935 211 HAAAqMGHNTVIVWLMSFTTVSLSERDD----------DGATAMHFAASRG 251
Cdd:cd22192  174 HILV-LQPNKTFACQMYDLILSYDKEDDlqpldlvpnnQGLTPFKLAAKEG 223
Ank_4 pfam13637
Ankyrin repeats (many copies);
141-192 1.24e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.81  E-value: 1.24e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 971428935  141 PVHYAAAKGDFPSLRLLLGHCPStLSAQTKTGATPLYLACQEGHLEIIQYLV 192
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGAD-INAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
259-312 1.35e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 48.88  E-value: 1.35e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 971428935  259 LLLHGGE--ITADGWGGTPLHDAAENGELECCQILVVNGADLSIRDQDGYTAADLA 312
Cdd:pfam13857   1 LLEHGPIdlNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
106-158 2.08e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.42  E-value: 2.08e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 971428935  106 TILHLAARFGHHEVIEWLLRFGgSDPTAATDTGALPVHYAAAKGDFPSLRLLL 158
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKG-ADINAVDGNGETALHFAASNGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 171-298 2.28e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 54.49  E-value: 2.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 171 TGATPLYLACQEGHLEIIQYLVKDcGADPHVRANDGMTPLHAAAQMGHNTVIVWLMSFTTVSLSERDDDgatAMHFAASR 250
Cdd:PLN03192 557 KGRTPLHIAASKGYEDCVLVLLKH-ACNVHIRDANGNTALWNAISAKHHKIFRILYHFASISDPHAAGD---LLCTAAKR 632

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 971428935 251 GHAKVLSWLLLHGGEI-TADGWGGTPLHDAAENGELECCQILVVNGADL 298
Cdd:PLN03192 633 NDLTAMKELLKQGLNVdSEDHQGATALQVAMAEDHVDMVRLLIMNGADV 681
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 98-268 2.88e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 54.49  E-value: 2.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935  98 QDTDNSGATILHLAARFGHHEVIEWLLRfGGSDPTAATDTGALPVHYAAAKGDFPSLRLLLGH-CpsTLSAQTKTGATPL 176
Cdd:PLN03192 519 EHDDPNMASNLLTVASTGNAALLEELLK-AKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHaC--NVHIRDANGNTAL 595

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 177 YLACQEGHLEIIQYLVKDCGA-DPHVrandGMTPLHAAAQMGHNTVIVWLMSFTtVSLSERDDDGATAMHFAASRGHAKV 255
Cdd:PLN03192 596 WNAISAKHHKIFRILYHFASIsDPHA----AGDLLCTAAKRNDLTAMKELLKQG-LNVDSEDHQGATALQVAMAEDHVDM 670

                        170
                 ....*....|...
gi 971428935 256 LSWLLLHGGEITA 268
Cdd:PLN03192 671 VRLLIMNGADVDK 683
Ank_4 pfam13637
Ankyrin repeats (many copies);
242-292 3.11e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.65  E-value: 3.11e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 971428935  242 TAMHFAASRGHAKVLSWLLLHGGEITA-DGWGGTPLHDAAENGELECCQILV 292
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAvDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
38-90 3.26e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.65  E-value: 3.26e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 971428935   38 SPAHHAARAGRLACLRYLAaEAALRGDARARNGATPAHDAAATGNLACLQWLL 90
Cdd:pfam13637   3 TALHAAAASGHLELLRLLL-EKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 183-324 1.09e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 51.92  E-value: 1.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 183 GHLEIIQYLVkDCGADPHVRANDGMTPLHAAAQMGHNTVIVWLMSFTTVSlSERDDDGATAMHFAASRGHAKVLSWLLLH 262
Cdd:PHA02875  13 GELDIARRLL-DIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIP-DVKYPDIESELHDAVEEGDVKAVEELLDL 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 971428935 263 GGEITADGW--GGTPLHDAAENGELECCQILVVNGADLSIRDQDGYTAADLADYNGHIHCAKYL 324
Cdd:PHA02875  91 GKFADDVFYkdGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELL 154
Ank_5 pfam13857
Ankyrin repeats (many copies);
89-145 6.77e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.87  E-value: 6.77e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 971428935   89 LLTQGGCGVQDTDNSGATILHLAARFGHHEVIEWLLRFgGSDPTAATDTGALPVHYA 145
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAY-GVDLNLKDEEGLTALDLA 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 78-186 7.66e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.51  E-value: 7.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935  78 AATGNLACLQWLLTqGGCGVQDTDNSGATILHLAARFGHHEVIEWLLRFgGSDPTAATDTGALPVHYAAAKGDFPSLRLL 157
Cdd:PTZ00322  90 AASGDAVGARILLT-GGADPNCRDYDGRTPLHIACANGHVQVVRVLLEF-GADPTLLDKDGKTPLELAEENGFREVVQLL 167

                         90       100
                 ....*....|....*....|....*....
gi 971428935 158 LGHCPSTLSAQTKtgATPLYLACQEGHLE 186
Cdd:PTZ00322 168 SRHSQCHFELGAN--AKPDSFTGKPPSLE 194
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 196-275 1.02e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.13  E-value: 1.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 196 GADPHVRANDGMTPLHAAAQMGHNTVIVWLMSF-TTVSLSERddDGATAMHFAASRGHAKVLSWLLLHGGEITADGWGGT 274
Cdd:PTZ00322 105 GADPNCRDYDGRTPLHIACANGHVQVVRVLLEFgADPTLLDK--DGKTPLELAEENGFREVVQLLSRHSQCHFELGANAK 182


                 .
gi 971428935 275 P 275
Cdd:PTZ00322 183 P 183
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 9-201 1.09e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 48.83  E-value: 1.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935   9 AARQGDVEALRGLRAAGLL----RPGLRdalgaSPAHHAARAGRLACLRYLAAEAALRGDARARNGATPAHDAAATGNLA 84
Cdd:PHA02875  42 AMKFRDSEAIKLLMKHGAIpdvkYPDIE-----SELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLD 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935  85 CLQWLLTQGGcgvqDTDNSGA---TILHLAARFGHHEVIEWLLrfggsDPTAATDT----GALPVHYAAAKGDFPSLRLL 157
Cdd:PHA02875 117 IMKLLIARGA----DPDIPNTdkfSPLHLAVMMGDIKGIELLI-----DHKACLDIedccGCTPLIIAMAKGDIAICKML 187

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 971428935 158 LGHCPSTLSAQTKTGATPLYLACQEGHLEIIQYLVKDcGADPHV 201
Cdd:PHA02875 188 LDSGANIDYFGKNGCVAALCYAIENNKIDIVRLFIKR-GADCNI 230
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 165-307 1.23e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 48.86  E-value: 1.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 165 LSAQTKTGATPLYLACQEGHLEIIQYLVKDCGADPHVRANDGMTPLHAAAQMGHNTVIVWLMSFT--------TVSLSEr 236
Cdd:cd22192   10 LLQQKRISESPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAApelvnepmTSDLYQ- 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 237 dddGATAMHFAASRGHAKVLSWLLLHGGEIT---ADG------------WGGTPLHDAAENGELECCQILVVNGADLSIR 301
Cdd:cd22192   89 ---GETALHIAVVNQNLNLVRELIARGADVVsprATGtffrpgpknliyYGEHPLSFAACVGNEEIVRLLIEHGADIRAQ 165


                 ....*.
gi 971428935 302 DQDGYT 307
Cdd:cd22192  166 DSLGNT 171
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 174-326 1.68e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 48.04  E-value: 1.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 174 TPLYLACQEGHLEIIQYLVKDcGAD-PHVRANDGmTPLHAAAQMGHNTVIVWLM-----------------SFTT----- 230
Cdd:PHA02874  37 TPLIDAIRSGDAKIVELFIKH-GADiNHINTKIP-HPLLTAIKIGAHDIIKLLIdngvdtsilpipciekdMIKTildcg 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 231 VSLSERDDDGATAMHFAASRGHAKVLSWLLLHGGEIT-ADGWGGTPLHDAAENGELECCQILVVNGADLSIRDQDGYTAA 309
Cdd:PHA02874 115 IDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNiEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPL 194

                        170
                 ....*....|....*..
gi 971428935 310 DLADYNGHIHCAKYLRT 326
Cdd:PHA02874 195 HNAAEYGDYACIKLLID 211
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 154-307 2.06e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 47.74  E-value: 2.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 154 LRLLL--GHCPSTlsaQTKTGATPLYLACQEGH-----LEIIQYLVKDcGADPHVRANDGMTPLHAAAQ--MGHNTVIVW 224
Cdd:PHA03100  51 VKILLdnGADINS---STKNNSTPLHYLSNIKYnltdvKEIVKLLLEY-GANVNAPDNNGITPLLYAISkkSNSYSIVEY 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 225 LMSF---TTVSLSerddDGATAMHFAASRGHA--KVLSWLLLHGGEITA-----------------DGWGGTPLHDAAEN 282
Cdd:PHA03100 127 LLDNganVNIKNS----DGENLLHLYLESNKIdlKILKLLIDKGVDINAknrvnyllsygvpinikDVYGFTPLHYAVYN 202

                        170       180
                 ....*....|....*....|....*
gi 971428935 283 GELECCQILVVNGADLSIRDQDGYT 307
Cdd:PHA03100 203 NNPEFVKYLLDLGANPNLVNKYGDT 227
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 118-294 2.26e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 47.95  E-value: 2.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 118 EVIEWLLRFGGSDPTAATDTGALPVHYAAAKGDFPSLRLLL--GHCPSTLSaqtKTGATPLYLACQEGHLEIIQYLVKDc 195
Cdd:PHA02878 148 EITKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLsyGANVNIPD---KTNNSPLHHAVKHYNKPIVHILLEN- 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 196 GADPHVRANDGMTPLHAAAQMGHNTVIVWLMSFTTVSLSERDD-DGATAMHFAASrgHAKVLSWLLLHGGEITADGWGG- 273
Cdd:PHA02878 224 GASTDARDKCGNTPLHISVGYCKDYDILKLLLEHGVDVNAKSYiLGLTALHSSIK--SERKLKLLLEYGADINSLNSYKl 301

                        170       180
                 ....*....|....*....|..
gi 971428935 274 TPLHDAAEN-GELECCQILVVN 294
Cdd:PHA02878 302 TPLSSAVKQyLCINIGRILISN 323
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 146-227 3.48e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.59  E-value: 3.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 146 AAKGDFPSLRLLLGHCPSTlSAQTKTGATPLYLACQEGHLEIIQYLVkDCGADPHVRANDGMTPLHAAAQMGHNTVIVWL 225
Cdd:PTZ00322  90 AASGDAVGARILLTGGADP-NCRDYDGRTPLHIACANGHVQVVRVLL-EFGADPTLLDKDGKTPLELAEENGFREVVQLL 167


                 ..
gi 971428935 226 MS 227
Cdd:PTZ00322 168 SR 169
PHA02946 PHA02946
ankyin-like protein; Provisional
 90-250 7.26e-05

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 46.20  E-value: 7.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935  90 LTQGGCGVQDTDNSGATILHLAARFGHHEVIEWLLRFgGSDPTAATDTGALPVHYAAAKGD--FPSLRLLLGHCPSTLSA 167
Cdd:PHA02946  58 LLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTH-GADPNACDKQHKTPLYYLSGTDDevIERINLLVQYGAKINNS 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 168 QTKTGATPLyLACQEGHLEIIQYLVKdCGADPHVRANDGMTPLHAAAqMGHN---TVIVWLMSFtTVSLSERDDDGATAM 244
Cdd:PHA02946 137 VDEEGCGPL-LACTDPSERVFKKIMS-IGFEARIVDKFGKNHIHRHL-MSDNpkaSTISWMMKL-GISPSKPDHDGNTPL 212


                 ....*.
gi 971428935 245 HFAASR 250
Cdd:PHA02946 213 HIVCSK 218
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 104-127 1.70e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 39.55  E-value: 1.70e-04
                          10        20
                  ....*....|....*....|....
gi 971428935  104 GATILHLAARFGHHEVIEWLLRFG 127
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLLENG 25
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 7-215 1.78e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 45.05  E-value: 1.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935   7 LQAARQGDVEALRGLRAAGLLRPGLrDALGASPAHHAARAGRLACLRYLAAEAALRGDARARNGATPAHDAAATG-NLAC 85
Cdd:PHA02876 245 LKAIRNEDLETSLLLYDAGFSVNSI-DDCKNTPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGyDTEN 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935  86 LQWLLTQGGcGVQDTDNSGATILHLAARFGHHEVIEWLLRFGGSDPTAATDTGALPVHYAAAKGDFPSLRLLLGHCPSTL 165
Cdd:PHA02876 324 IRTLIMLGA-DVNAADRLYITPLHQASTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIE 402

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 971428935 166 SAQTKTGATPLYLACQEGHLEIIQYLVkDCGADPHVRANDGMTPLHAAAQ 215
Cdd:PHA02876 403 ALSQKIGTALHFALCGTNPYMSVKTLI-DRGANVNSKNKDLSTPLHYACK 451
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 245-364 2.03e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.89  E-value: 2.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 245 HFAASrGHAkVLSWLLLHGGEIT--ADGWGGTPLHDAAENGELECCQILVVNGADLSIRDQDGYTAADLADYNGhihcak 322
Cdd:PTZ00322  88 QLAAS-GDA-VGARILLTGGADPncRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENG------ 159

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 971428935 323 yLRTVENMSVEHrvlSRDPSADGECRQPDSGMSSPNTTASAP 364
Cdd:PTZ00322 160 -FREVVQLLSRH---SQCHFELGANAKPDSFTGKPPSLEDSP 197
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 172-201 2.88e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 38.72  E-value: 2.88e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 971428935   172 GATPLYLACQEGHLEIIQYLVkDCGADPHV 201
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLL-DKGADINA 30
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 172-324 3.83e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.83  E-value: 3.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 172 GATPLYLACQEGHLEIIQYLVKDcGADPHVRANDGMTPLHAAAQMGHNTVIVWLMSFTTVSLSERDDDGATAMHFAASRG 251
Cdd:PHA02875  35 GISPIKLAMKFRDSEAIKLLMKH-GAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILK 113

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 971428935 252 HAKVLSWLLLHGGEI---TADGWggTPLHDAAENGELECCQILVVNGADLSIRDQDGYTAADLADYNGHIHCAKYL 324
Cdd:PHA02875 114 KLDIMKLLIARGADPdipNTDKF--SPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKML 187
Ank_5 pfam13857
Ankyrin repeats (many copies);
157-213 4.29e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.87  E-value: 4.29e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 971428935  157 LLGHCPSTLSAQTKTGATPLYLACQEGHLEIIQYLVKDcGADPHVRANDGMTPLHAA 213
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAY-GVDLNLKDEEGLTALDLA 56
Ank_5 pfam13857
Ankyrin repeats (many copies);
191-247 7.36e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.48  E-value: 7.36e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 971428935  191 LVKDCGADPHVRANDGMTPLHAAAQMGHNTVIVWLMSFtTVSLSERDDDGATAMHFA 247
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAY-GVDLNLKDEEGLTALDLA 56
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 9-145 7.51e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.03  E-value: 7.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935   9 AARQGDVEALRGLRAAGLlRPGLRDALGASPAHHAARAGRLACLRYLAAEAALrGDARARNGATPAHDAAATGNLACLQW 88
Cdd:PHA02874 131 AIKKGDLESIKMLFEYGA-DVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAY-ANVKDNNGESPLHNAAEYGDYACIKL 208

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 971428935  89 LLTQGGcGVQDTDNSGATILHLAARFgHHEVIEWLLRFGGSDPTAAtdTGALPVHYA 145
Cdd:PHA02874 209 LIDHGN-HIMNKCKNGFTPLHNAIIH-NRSAIELLINNASINDQDI--DGSTPLHHA 261
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 172-204 1.05e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 1.05e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 971428935  172 GATPLYLAC-QEGHLEIIQYLVkDCGADPHVRAN 204
Cdd:pfam00023   2 GNTPLHLAAgRRGNLEIVKLLL-SKGADVNARDK 34
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 235-317 1.08e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 42.55  E-value: 1.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 235 ERDDDGATAMHF--AASRGHAKVLSWLLLHGGEI-TADGWGGTPLHDAAENGELECCQILVVNGADLSIRDQDGYTAADL 311
Cdd:PLN03192 518 GEHDDPNMASNLltVASTGNAALLEELLKAKLDPdIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWN 597


                 ....*.
gi 971428935 312 ADYNGH 317
Cdd:PLN03192 598 AISAKH 603
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 104-129 1.17e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 1.17e-03
                           10        20
                   ....*....|....*....|....*.
gi 971428935   104 GATILHLAARFGHHEVIEWLLRFGGS 129
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGAD 27
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 172-201 1.56e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.47  E-value: 1.56e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 971428935  172 GATPLYLACQEGHLEIIQYLVkDCGADPHV 201
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLL-ENGADINA 30
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 269-302 1.93e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.50  E-value: 1.93e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 971428935  269 DGWggTPLHDAA-ENGELECCQILVVNGADLSIRD 302
Cdd:pfam00023   1 DGN--TPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
Ank_4 pfam13637
Ankyrin repeats (many copies);
8-55 2.73e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.48  E-value: 2.73e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 971428935    8 QAARQGDVEALRGLRAAGLlRPGLRDALGASPAHHAARAGRLACLRYL 55
Cdd:pfam13637   7 AAAASGHLELLRLLLEKGA-DINAVDGNGETALHFAASNGNVEVLKLL 53
Ank_5 pfam13857
Ankyrin repeats (many copies);
55-111 2.78e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.56  E-value: 2.78e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 971428935   55 LAAEAALRGDARARNGATPAHDAAATGNLACLQWLLTqGGCGVQDTDNSGATILHLA 111
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLA-YGVDLNLKDEEGLTALDLA 56
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 238-307 3.12e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 41.02  E-value: 3.12e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 971428935 238 DDGATAMHFAASRGHAKVLSWLLLHGGEITA-DGWGGTPLHDAAENGELECCQILVVNGADLSIRDQDGYT 307
Cdd:PHA02878 166 HKGNTALHYATENKDQRLTELLLSYGANVNIpDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNT 236
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 172-260 3.97e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 40.55  E-value: 3.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 172 GATPLYLACQEGHLEIIQYLVKDCGADPHVRAND--GMTPLHAAAQMGHNTV-----------IVWLMS---FTTVSLSE 235
Cdd:cd22193  123 GELPLSLAACTNQPDIVQYLLENEHQPADIEAQDsrGNTVLHALVTVADNTKentkfvtrmydMILIRGaklCPTVELEE 202

                         90       100
                 ....*....|....*....|....*.
gi 971428935 236 -RDDDGATAMHFAASRGHAKVLSWLL 260
Cdd:cd22193  203 iRNNDGLTPLQLAAKMGKIEILKYIL 228
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 100-213 5.10e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 40.25  E-value: 5.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 100 TDNSGATILHLAARFGHHEVIEWLLRFgGSDPTAATDTGALPVHYAAAKGDFPSLRLLLGHCPSTlSAQTKTGATPLYLA 179
Cdd:PHA02878 164 DRHKGNTALHYATENKDQRLTELLLSY-GANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAST-DARDKCGNTPLHIS 241

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 971428935 180 CqeGHL---EIIQYLVKDcGADPHVRAN-DGMTPLHAA 213
Cdd:PHA02878 242 V--GYCkdyDILKLLLEH-GVDVNAKSYiLGLTALHSS 276
Ank_5 pfam13857
Ankyrin repeats (many copies);
236-277 5.60e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.79  E-value: 5.60e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 971428935  236 RDDDGATAMHFAASRGHAKVLSWLLLHGGEITA-DGWGGTPLH 277
Cdd:pfam13857  12 LDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLkDEEGLTALD 54
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 89-266 7.04e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 39.65  E-value: 7.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935  89 LLTQGGCGVQDTDNSgATILHLAARFGHHEV----IEWLLRFGGSDPTAATDTGALPVHYAAAK--GDFPSLRLLLGHcP 162
Cdd:PHA03100  54 LLDNGADINSSTKNN-STPLHYLSNIKYNLTdvkeIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDN-G 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428935 163 STLSAQTKTGATPL--YLACQEGHLEIIQYLVK-----------DC----GADPHVRANDGMTPLHAAAQMGH-NTVIVW 224
Cdd:PHA03100 132 ANVNIKNSDGENLLhlYLESNKIDLKILKLLIDkgvdinaknrvNYllsyGVPINIKDVYGFTPLHYAVYNNNpEFVKYL 211

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 971428935 225 LMSFTTVSLseRDDDGATAMHFAASRGHAKVLSWLLLHGGEI 266
Cdd:PHA03100 212 LDLGANPNL--VNKYGDTPLHIAILNNNKEIFKLLLNNGPSI 251
WH2 pfam02205
WH2 motif; The WH2 motif (for Wiskott Aldrich syndrome homology region 2) has been shown in ...
 624-649 7.96e-03

WH2 motif; The WH2 motif (for Wiskott Aldrich syndrome homology region 2) has been shown in WASP and Scar1 (mammalian homolog) to be the region that interacts with actin.


Pssm-ID: 460490  Cd Length: 28  Bit Score: 34.40  E-value: 7.96e-03
                          10        20
                  ....*....|....*....|....*.
gi 971428935  624 PTGDNSELLAEIKAGKSLKPTPQSKG 649
Cdd:pfam02205   1 GGGGRGALLADIRAGKKLKKVEETND 26
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 104-136 9.40e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.57  E-value: 9.40e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 971428935  104 GATILHLAA-RFGHHEVIEWLLRFgGSDPTAATD 136
Cdd:pfam00023   2 GNTPLHLAAgRRGNLEIVKLLLSK-GADVNARDK 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH