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Conserved domains on  [gi|966974090|ref|XP_015008017|]
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nucleoporin Nup37 isoform X2 [Macaca mulatta]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
3-115 3.21e-12

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.93  E-value: 3.21e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966974090   3 IRLFtsDLQDKNEYKVLEGHTDFINGLVFDPkEGQEIASVSDDHTCRIWNLEGVQTAHFVLHSPGM--SVCWHPEETFkL 80
Cdd:COG2319  186 VRLW--DLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSvrSVAFSPDGRL-L 261

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 966974090  81 MVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHW 115
Cdd:COG2319  262 ASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF 296
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
3-115 3.21e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.93  E-value: 3.21e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966974090   3 IRLFtsDLQDKNEYKVLEGHTDFINGLVFDPkEGQEIASVSDDHTCRIWNLEGVQTAHFVLHSPGM--SVCWHPEETFkL 80
Cdd:COG2319  186 VRLW--DLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSvrSVAFSPDGRL-L 261

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 966974090  81 MVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHW 115
Cdd:COG2319  262 ASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF 296
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-115 4.62e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.81  E-value: 4.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966974090   3 IRLFtsDLQDKNEYKVLEGHTDFINGLVFDPKeGQEIASVSDDHTCRIWNL-EGVQTAHFVLHSPG-MSVCWHPEETFkL 80
Cdd:cd00200  159 IKLW--DLRTGKCVATLTGHTGEVNSVAFSPD-GEKLLSSSSDGTIKLWDLsTGKCLGTLRGHENGvNSVAFSPDGYL-L 234

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 966974090  81 MVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHW 115
Cdd:cd00200  235 ASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAW 269
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 12-52 5.69e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 5.69e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 966974090    12 DKNEYKVLEGHTDFINGLVFDPkEGQEIASVSDDHTCRIWN 52
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
17-52 2.37e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 2.37e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 966974090   17 KVLEGHTDFINGLVFDPkEGQEIASVSDDHTCRIWN 52
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
3-115 3.21e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.93  E-value: 3.21e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966974090   3 IRLFtsDLQDKNEYKVLEGHTDFINGLVFDPkEGQEIASVSDDHTCRIWNLEGVQTAHFVLHSPGM--SVCWHPEETFkL 80
Cdd:COG2319  186 VRLW--DLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSvrSVAFSPDGRL-L 261

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 966974090  81 MVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHW 115
Cdd:COG2319  262 ASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF 296
WD40 COG2319
WD40 repeat [General function prediction only];
3-137 6.52e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.16  E-value: 6.52e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966974090   3 IRLFtsDLQDKNEYKVLEGHTDFINGLVFDPkEGQEIASVSDDHTCRIWNLE-GVQTAHFVLHSPGM-SVCWHPEETFkL 80
Cdd:COG2319  102 VRLW--DLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLAtGKLLRTLTGHSGAVtSVAFSPDGKL-L 177

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966974090  81 MVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVAGNDWLIWDIT 137
Cdd:COG2319  178 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA 234
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-115 4.62e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.81  E-value: 4.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966974090   3 IRLFtsDLQDKNEYKVLEGHTDFINGLVFDPKeGQEIASVSDDHTCRIWNL-EGVQTAHFVLHSPG-MSVCWHPEETFkL 80
Cdd:cd00200  159 IKLW--DLRTGKCVATLTGHTGEVNSVAFSPD-GEKLLSSSSDGTIKLWDLsTGKCLGTLRGHENGvNSVAFSPDGYL-L 234

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 966974090  81 MVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHW 115
Cdd:cd00200  235 ASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAW 269
WD40 COG2319
WD40 repeat [General function prediction only];
2-115 4.91e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 4.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966974090   2 KIRLFtsDLQDKNEYKVLEGHTDFINGLVFDPkEGQEIASVSDDHTCRIWNLE-GVQTAHFVLHS-PGMSVCWHPEETFk 79
Cdd:COG2319  269 TVRLW--DLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTgAVRSVAFSPDGKT- 344

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 966974090  80 LMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHW 115
Cdd:COG2319  345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380
WD40 COG2319
WD40 repeat [General function prediction only];
3-94 2.43e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.54  E-value: 2.43e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966974090   3 IRLFtsDLQDKNEYKVLEGHTDFINGLVFDPKeGQEIASVSDDHTCRIWNLEGVQTAH-FVLHSPG-MSVCWHPEETFkL 80
Cdd:COG2319  312 VRLW--DLATGKLLRTLTGHTGAVRSVAFSPD-GKTLASGSDDGTVRLWDLATGELLRtLTGHTGAvTSVAFSPDGRT-L 387

                         90
                 ....*....|....
gi 966974090  81 MVAEKNGTIRFYDL 94
Cdd:COG2319  388 ASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-93 3.99e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.12  E-value: 3.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966974090   3 IRLFtsDLQDKNEYKVLEGHTDFINGLVFDPKeGQEIASVSDDHTCRIWNLE-GVQTAHFVLHSPG-MSVCWHPEETFkL 80
Cdd:cd00200  201 IKLW--DLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASGSEDGTIRVWDLRtGECVQTLSGHTNSvTSLAWSPDGKR-L 276

                         90
                 ....*....|...
gi 966974090  81 MVAEKNGTIRFYD 93
Cdd:cd00200  277 ASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-170 4.02e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.12  E-value: 4.02e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966974090   2 KIRLFtsDLQDKNEYKVLEGHTDFINGLVFDPKeGQEIASVSDDHTCRIWNLEGVQTAH-FVLH-SPGMSVCWHPEETFk 79
Cdd:cd00200   32 TIKVW--DLETGELLRTLKGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLETGECVRtLTGHtSYVSSVAFSPDGRI- 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966974090  80 LMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVAGNDWLIWDItRSSYPQNKRPVHMDRACLFRWS 159
Cdd:cd00200  108 LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL-RTGKCVATLTGHTGEVNSVAFS 186

                        170
                 ....*....|.
gi 966974090 160 TISENLFATTG 170
Cdd:cd00200  187 PDGEKLLSSSS 197
WD40 COG2319
WD40 repeat [General function prediction only];
3-55 2.13e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.68  E-value: 2.13e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 966974090   3 IRLFtsDLQDKNEYKVLEGHTDFINGLVFDPkEGQEIASVSDDHTCRIWNLEG 55
Cdd:COG2319  354 VRLW--DLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-137 1.62e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.71  E-value: 1.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966974090  15 EYKVLEGHTDFINGLVFDPkEGQEIASVSDDHTCRIWNLEGVQTAH-FVLHSPGMSVC-WHPEETFkLMVAEKNGTIRFY 92
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRtLKGHTGPVRDVaASADGTY-LASGSSDKTIRLW 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 966974090  93 DLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVAGNDWLIWDIT 137
Cdd:cd00200   79 DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE 123
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 12-52 5.69e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 5.69e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 966974090    12 DKNEYKVLEGHTDFINGLVFDPkEGQEIASVSDDHTCRIWN 52
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
17-52 2.37e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 2.37e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 966974090   17 KVLEGHTDFINGLVFDPkEGQEIASVSDDHTCRIWN 52
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
9-104 2.74e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.13  E-value: 2.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966974090   9 DLQDKNEYKVLEGHTDFINGLVFDPkEGQEIASVSDDHTCRIWNLE-GVQTAHFVLH-SPGMSVCWHPEETFkLMVAEKN 86
Cdd:COG2319   64 DAAAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLAtGLLLRTLTGHtGAVRSVAFSPDGKT-LASGSAD 141

                         90
                 ....*....|....*...
gi 966974090  87 GTIRFYDLLAQQAILSLE 104
Cdd:COG2319  142 GTVRLWDLATGKLLRTLT 159
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-52 1.07e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.32  E-value: 1.07e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 966974090   2 KIRLFtsDLQDKNEYKVLEGHTDFINGLVFDPkEGQEIASVSDDHTCRIWN 52
Cdd:cd00200  242 TIRVW--DLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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