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Conserved domains on  [gi|966972164|ref|XP_015007114|]
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aquaporin-2 isoform X1 [Macaca mulatta]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 11088534)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11473620|8849412|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 3-261 2.56e-98

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


:

Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 288.83  E-value: 2.56e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164    3 ELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPS-----VLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLV 77
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSlavsgLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164   78 GCHVSFLRATFYVAAQLLGAVAGAALLHEITPADIRGDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENP 157
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164  158 GT-PALSIGFSVALGHLLGvghghrfqppwrnrhtdhsrdrhrdpkrdtytelsrgtdtpeIHYTGCSMNPARSLAPAVV 236
Cdd:pfam00230 161 GTvAPLAIGFAVFLNHLAG------------------------------------------GPYTGASMNPARSFGPAVV 198

                         250       260
                  ....*....|....*....|....*
gi 966972164  237 TGKFDDHWVFWIGPLVGAILGSLLY 261
Cdd:pfam00230 199 LWKWDDHWVYWVGPFIGAALGALVY 223
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 3-261 2.56e-98

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 288.83  E-value: 2.56e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164    3 ELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPS-----VLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLV 77
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSlavsgLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164   78 GCHVSFLRATFYVAAQLLGAVAGAALLHEITPADIRGDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENP 157
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164  158 GT-PALSIGFSVALGHLLGvghghrfqppwrnrhtdhsrdrhrdpkrdtytelsrgtdtpeIHYTGCSMNPARSLAPAVV 236
Cdd:pfam00230 161 GTvAPLAIGFAVFLNHLAG------------------------------------------GPYTGASMNPARSFGPAVV 198

                         250       260
                  ....*....|....*....|....*
gi 966972164  237 TGKFDDHWVFWIGPLVGAILGSLLY 261
Cdd:pfam00230 199 LWKWDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 11-264 9.22e-78

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 236.77  E-value: 9.22e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164  11 RAVFAEFLATLLFVFFGLGSALNW---PQALPSVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSFLRAT 87
Cdd:cd00333    1 RKYLAEFLGTFLLVFFGCGSVLAVklaGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164  88 FYVAAQLLGAVAGAALLHEITPADIRGDLAVNA---------LSNSTTAGQAVTVELFLTLQLVLCIFASTDERRG-ENP 157
Cdd:cd00333   81 PYIIAQLLGAILGAALLYGLYYGLYLEFLGANNivagifgtyPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNGpPPG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164 158 GTPALSIGFSVALGHLLGvghghrfqppwrnrhtdhsrdrhrdpkrdtytelsrgtdtpeIHYTGCSMNPARSLAPAVVT 237
Cdd:cd00333  161 GLAPLAIGLLVAAIGLAG------------------------------------------GPITGASMNPARSLGPALFT 198

                        250       260       270
                 ....*....|....*....|....*....|
gi 966972164 238 G---KFDDHWVFWIGPLVGAILGSLLYNYV 264
Cdd:cd00333  199 GlarHWHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 15-261 3.70e-65

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 204.07  E-value: 3.70e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164   15 AEFLATLLFVFFGLGSAL-------NWPQALPSVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSFLRAT 87
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALgvnvagaYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164   88 FYVAAQLLGAVAGAALLHEITPADIRGDLAVNAL-SNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPA-LSIG 165
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSaSAGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVPRGGFApLAIG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164  166 FSVALGHLLGvghghrfqppwrnrhtdhsrdrhrdpkrdtytelsrgtdtpeIHYTGCSMNPARSLAPAVVTGK--FDDH 243
Cdd:TIGR00861 161 LLVFLIHLSM------------------------------------------GPYTGTGMNPARSLGPALFAGLagWGNH 198

                         250
                  ....*....|....*...
gi 966972164  244 WVFWIGPLVGAILGSLLY 261
Cdd:TIGR00861 199 WVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 11-265 4.20e-48

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 160.68  E-value: 4.20e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164  11 RAVFAEFLATLLFVFFGLGSA--LNWPQALPSVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSFLRATF 88
Cdd:COG0580    4 KRLLAEFLGTFILVLLGCGVVavLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKDVLP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164  89 YVAAQLLGAVAGAALLHEI---TPADIRGDLAVNAL-----SNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTP 160
Cdd:COG0580   84 YIIAQLLGAFLGAALVYLIyggHFDATEDGGAKLGVfatspAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAAPGGLAP 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164 161 aLSIGFSVALGHLLGVGhghrfqppwrnrhtdhsrdrhrdpkrdtytelsrgtdtpeihYTGCSMNPARSLAPAVVTGKF 240
Cdd:COG0580  164 -LAIGLLVAAIGLSLGP------------------------------------------LTGYAINPARDLGPRLFHALG 200

                        250       260       270
                 ....*....|....*....|....*....|.
gi 966972164 241 D------DHWVFWIGPLVGAILGSLLYNYVL 265
Cdd:COG0580  201 KggsdwgYLWVPIVAPILGAALAALLYRALF 231
PLN00166 PLN00166
aquaporin TIP2; Provisional
 6-265 6.07e-35

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 127.36  E-value: 6.07e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164   6 SIAFSRAVFAEFLATLLFVFFGLGSALNW----------PQALPSVlQIAMAFGLGIGTLVQAlgHISGAHINPAVTVAC 75
Cdd:PLN00166  14 SVASLKAYLSEFIATLLFVFAGVGSAIAFakltsdaaldPAGLVAV-AVAHAFALFVGVSIAA--NISGGHLNPAVTLGL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164  76 LVGCHVSFLRATFYVAAQLLGAVAGAALLHEITPADirgDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGE 155
Cdd:PLN00166  91 AIGGNITIITGFFYWIAQCLGSIVACLLLVFVTNGE---SVPTHGVAAGLGAIEGVVMEIVVTFALVYTVYATAADPKKG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164 156 NPGTPA-LSIGFSVAlGHLLGVGhghrfqppwrnrhtdhsrdrhrdpkrdtytelsrgtdtpeiHYTGCSMNPARSLAPA 234
Cdd:PLN00166 168 SLGTIApIAIGFIVG-ANILAAG-----------------------------------------PFSGGSMNPARSFGPA 205

                        250       260       270
                 ....*....|....*....|....*....|.
gi 966972164 235 VVTGKFDDHWVFWIGPLVGAILGSLLYNYVL 265
Cdd:PLN00166 206 VVSGDFSQIWIYWVGPLVGGALAGLIYGDVF 236
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 3-261 2.56e-98

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 288.83  E-value: 2.56e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164    3 ELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPS-----VLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLV 77
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSlavsgLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164   78 GCHVSFLRATFYVAAQLLGAVAGAALLHEITPADIRGDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENP 157
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164  158 GT-PALSIGFSVALGHLLGvghghrfqppwrnrhtdhsrdrhrdpkrdtytelsrgtdtpeIHYTGCSMNPARSLAPAVV 236
Cdd:pfam00230 161 GTvAPLAIGFAVFLNHLAG------------------------------------------GPYTGASMNPARSFGPAVV 198

                         250       260
                  ....*....|....*....|....*
gi 966972164  237 TGKFDDHWVFWIGPLVGAILGSLLY 261
Cdd:pfam00230 199 LWKWDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 11-264 9.22e-78

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 236.77  E-value: 9.22e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164  11 RAVFAEFLATLLFVFFGLGSALNW---PQALPSVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSFLRAT 87
Cdd:cd00333    1 RKYLAEFLGTFLLVFFGCGSVLAVklaGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164  88 FYVAAQLLGAVAGAALLHEITPADIRGDLAVNA---------LSNSTTAGQAVTVELFLTLQLVLCIFASTDERRG-ENP 157
Cdd:cd00333   81 PYIIAQLLGAILGAALLYGLYYGLYLEFLGANNivagifgtyPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNGpPPG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164 158 GTPALSIGFSVALGHLLGvghghrfqppwrnrhtdhsrdrhrdpkrdtytelsrgtdtpeIHYTGCSMNPARSLAPAVVT 237
Cdd:cd00333  161 GLAPLAIGLLVAAIGLAG------------------------------------------GPITGASMNPARSLGPALFT 198

                        250       260       270
                 ....*....|....*....|....*....|
gi 966972164 238 G---KFDDHWVFWIGPLVGAILGSLLYNYV 264
Cdd:cd00333  199 GlarHWHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 15-261 3.70e-65

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 204.07  E-value: 3.70e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164   15 AEFLATLLFVFFGLGSAL-------NWPQALPSVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSFLRAT 87
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALgvnvagaYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164   88 FYVAAQLLGAVAGAALLHEITPADIRGDLAVNAL-SNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPA-LSIG 165
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSaSAGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVPRGGFApLAIG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164  166 FSVALGHLLGvghghrfqppwrnrhtdhsrdrhrdpkrdtytelsrgtdtpeIHYTGCSMNPARSLAPAVVTGK--FDDH 243
Cdd:TIGR00861 161 LLVFLIHLSM------------------------------------------GPYTGTGMNPARSLGPALFAGLagWGNH 198

                         250
                  ....*....|....*...
gi 966972164  244 WVFWIGPLVGAILGSLLY 261
Cdd:TIGR00861 199 WVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 11-265 4.20e-48

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 160.68  E-value: 4.20e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164  11 RAVFAEFLATLLFVFFGLGSA--LNWPQALPSVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSFLRATF 88
Cdd:COG0580    4 KRLLAEFLGTFILVLLGCGVVavLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKDVLP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164  89 YVAAQLLGAVAGAALLHEI---TPADIRGDLAVNAL-----SNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTP 160
Cdd:COG0580   84 YIIAQLLGAFLGAALVYLIyggHFDATEDGGAKLGVfatspAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAAPGGLAP 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164 161 aLSIGFSVALGHLLGVGhghrfqppwrnrhtdhsrdrhrdpkrdtytelsrgtdtpeihYTGCSMNPARSLAPAVVTGKF 240
Cdd:COG0580  164 -LAIGLLVAAIGLSLGP------------------------------------------LTGYAINPARDLGPRLFHALG 200

                        250       260       270
                 ....*....|....*....|....*....|.
gi 966972164 241 D------DHWVFWIGPLVGAILGSLLYNYVL 265
Cdd:COG0580  201 KggsdwgYLWVPIVAPILGAALAALLYRALF 231
PLN00166 PLN00166
aquaporin TIP2; Provisional
 6-265 6.07e-35

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 127.36  E-value: 6.07e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164   6 SIAFSRAVFAEFLATLLFVFFGLGSALNW----------PQALPSVlQIAMAFGLGIGTLVQAlgHISGAHINPAVTVAC 75
Cdd:PLN00166  14 SVASLKAYLSEFIATLLFVFAGVGSAIAFakltsdaaldPAGLVAV-AVAHAFALFVGVSIAA--NISGGHLNPAVTLGL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164  76 LVGCHVSFLRATFYVAAQLLGAVAGAALLHEITPADirgDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGE 155
Cdd:PLN00166  91 AIGGNITIITGFFYWIAQCLGSIVACLLLVFVTNGE---SVPTHGVAAGLGAIEGVVMEIVVTFALVYTVYATAADPKKG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164 156 NPGTPA-LSIGFSVAlGHLLGVGhghrfqppwrnrhtdhsrdrhrdpkrdtytelsrgtdtpeiHYTGCSMNPARSLAPA 234
Cdd:PLN00166 168 SLGTIApIAIGFIVG-ANILAAG-----------------------------------------PFSGGSMNPARSFGPA 205

                        250       260       270
                 ....*....|....*....|....*....|.
gi 966972164 235 VVTGKFDDHWVFWIGPLVGAILGSLLYNYVL 265
Cdd:PLN00166 206 VVSGDFSQIWIYWVGPLVGGALAGLIYGDVF 236
PLN00027 PLN00027
aquaporin TIP; Provisional
 11-268 5.65e-33

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 122.20  E-value: 5.65e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164  11 RAVFAEFLATLLFVFFGLGSALNWPQ------ALPSVL---QIAMAFGLGIGTLVQAlgHISGAHINPAVTVACLVGCHV 81
Cdd:PLN00027  21 KAALAEFISTLIFVFAGEGSGMAFNKltdngsTTPAGLvaaALAHAFALFVAVSVGA--NISGGHVNPAVTFGAFIGGNI 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164  82 SFLRATFYVAAQLLGAVAGAALLHEITpadirGDLAVNA--LSNSTTAGQAVTVELFLTLQLVLCIFAST-DERRGENPG 158
Cdd:PLN00027  99 TLLRGILYWIAQLLGSVVACLLLKFST-----GGLETSAfsLSSGVGVWNAFVFEIVMTFGLVYTVYATAvDPKKGDLGI 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164 159 TPALSIGFSVALGHLLGVGhghrfqppwrnrhtdhsrdrhrdpkrdtytelsrgtdtpeihYTGCSMNPARSLAPAVVTG 238
Cdd:PLN00027 174 IAPIAIGFIVGANILAGGA------------------------------------------FDGASMNPAVSFGPAVVSW 211

                        250       260       270
                 ....*....|....*....|....*....|
gi 966972164 239 KFDDHWVFWIGPLVGAILGSLLYNYVLFPP 268
Cdd:PLN00027 212 TWTNHWVYWAGPLIGGGIAGLVYELIFIGS 241
PLN00167 PLN00167
aquaporin TIP5; Provisional
 11-268 2.46e-30

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 115.39  E-value: 2.46e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164  11 RAVFAEFLATLLFVFFGLGSALNWPQALP-------SVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSF 83
Cdd:PLN00167  23 RSYLAEFISTFFFVFAAVGSAMSSRKLMPdaasdpsSLLIVAIANAFALSSAVYIAANISGGHVNPAVTFGMAVGGHISV 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164  84 LRATFYVAAQLLGAVAGAALLHEITpadIRGDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALS 163
Cdd:PLN00167 103 PTAMFYWISQMLASVMACLFLKVTT---VGQHVPTYKIAEEMTGFGASVLEGVLTFGLVYTVYAAGDPRRGLLGAIGPLA 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164 164 IGFsVALGHLLGVGhghrfqppwrnrhtdhsrdrhrdpkrdtytelsrgtdtpeiHYTGCSMNPARSLAPAVVTGKFDDH 243
Cdd:PLN00167 180 IGL-VAGANVLAAG-----------------------------------------PFSGGSMNPACAFGSAVVAGSFKNQ 217

                        250       260
                 ....*....|....*....|....*
gi 966972164 244 WVFWIGPLVGAILGSLLYNYVLFPP 268
Cdd:PLN00167 218 AVYWVGPLLGGAVAGLLYDNVVFPT 242
PRK05420 PRK05420
aquaporin Z; Provisional
 10-265 6.53e-30

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 113.52  E-value: 6.53e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164  10 SRAVFAEFLATLLFVFFGLGSAL---NWPQALPSVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSFLRA 86
Cdd:PRK05420   2 FKKLAAEFFGTFWLVFGGCGSAVlaaAFPELGIGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKEL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164  87 TFYVAAQLLGAVAGAALLHEITPADIRGDLAVNAL-SN----------STTAgqAVTVELFLTLQLVLCIFASTDERrgE 155
Cdd:PRK05420  82 VPYIIAQVVGGIAAAAVLYLIASGKAGFDLAGSGFaSNgygehspggySLLA--ALVCEVVLTAFFLLVILGATDKR--A 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164 156 NPGTPALSIGFSVALGHLLGvghghrfqppwrnrhtdhsrdrhrdpkrdtytelsrgtdtpeIHYTGCSMNPARSLAPAV 235
Cdd:PRK05420 158 PAGFAPIAIGLALTLIHLIS------------------------------------------IPVTNTSVNPARSTGVAL 195

                        250       260       270
                 ....*....|....*....|....*....|..
gi 966972164 236 VTGKF--DDHWVFWIGPLVGAILGSLLYNYVL 265
Cdd:PRK05420 196 FVGGWalEQLWLFWVAPIVGAIIGGLIYRLLL 227
PLN00184 PLN00184
aquaporin NIP1; Provisional
 6-280 4.71e-23

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 96.63  E-value: 4.71e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164   6 SIAFSRAVFAEFLATLLFVFFGLGSALNWPQ-----ALPSvlqIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCH 80
Cdd:PLN00184  50 SVPFLQKLIAEVLGTYFLVFTGCASVVVNMQndnvvTLPG---IAIVWGLTIMVLIYSLGHISGAHINPAVTIAFASCGR 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164  81 VSFLRATFYVAAQLLGAVAGAALLHEITPADI-----RGDLAVNALSNSTTAgQAVTVELFLTLQLVLCIFA-STDERR- 153
Cdd:PLN00184 127 FPLKQVPAYVISQVIGSTLAAATLRLLFGLDHdvcsgKHDVFIGSSPVGSDL-QAFVMEFIVTFYLMFIISGvATDNRAi 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164 154 GENPGtpaLSIGFSVALGHLLGVGhghrfqppwrnrhtdhsrdrhrdpkrdtytelsrgtdtpeihYTGCSMNPARSLAP 233
Cdd:PLN00184 206 GELAG---LAIGSTVLLNVLIAAP------------------------------------------VSSASMNPGRSLGP 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 966972164 234 AVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLF--PPAKSLSERLAVLK 280
Cdd:PLN00184 241 AMVYGCYKGIWIYIVAPTLGAIAGAWVYNTVRYtdKPLREITKSGSFLK 289
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 11-261 1.15e-22

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 94.92  E-value: 1.15e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164  11 RAVFAEFLATLLFVF--FGLGSALNWPQALPSVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSFLRATF 88
Cdd:PLN00183  46 RMVLAEMVGTFILMFcvCGIIASTQLSGGEVGLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWSKVPL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164  89 YVAAQLLGAVagAALLHEITPADIRGDLAVNALSNSTTAgqAVTVELFLTLQLVLCIFASTDERRGENPGTpALSIGFSV 168
Cdd:PLN00183 126 YITAQTVGSV--LATYVGVSVYGVKADLMTTKPAQGCSS--AFWVEFIATFIVMFLAASLTSQPQSLGHLS-GFVIGIAI 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164 169 ALGHLLgvghghrfqppwrnrhtdhsrdrhrdpkrdtytelsrgtdTPEIhyTGCSMNPARSLAPAVVTGKFDDHWVFWI 248
Cdd:PLN00183 201 GLAVLI----------------------------------------TGPV--SGGSMNPARSLGPAIVSWDFKDIWIYIT 238

                        250
                 ....*....|...
gi 966972164 249 GPLVGAILGSLLY 261
Cdd:PLN00183 239 APTIGAVAGALMF 251
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 7-285 1.16e-22

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 95.36  E-value: 1.16e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164   7 IAFSRAVFAEFLATLLFVFFGLGSAL--NWPQALPSVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSFL 84
Cdd:PLN00182  39 VCLTQKLIAEMIGTYFIIFSGCGVVVvnVLYGGTITFPGICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWY 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164  85 RATFYVAAQLLGAVAGA---ALLHEITPADIRGDLAVNalsnstTAGQAVTVELFLTLQLVLCIFA-STDERrgenpgtp 160
Cdd:PLN00182 119 QVPLYIGAQLTGSLLASltlRLMFNVTPEAFFGTTPTD------SSGQALVAEIIISFLLMFVISGvATDSR-------- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164 161 alsigfsvALGHLLGVGHGHRFQppwrnrhtdhsrdrhrdpkrdtyteLSRGTDTPeihYTGCSMNPARSLAPAVVTGKF 240
Cdd:PLN00182 185 --------AVGELAGIAVGMTII-------------------------LNVFVAGP---ISGASMNPARSLGPAIVMGRY 228

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 966972164 241 DDHWVFWIGPLVGAILGSLLYNYVLF--PPAKSLSERLAVLKGLEPD 285
Cdd:PLN00182 229 KGIWVYIVGPFVGIIAGGFVYNLIRFtdKPLRELTKSASFLRSVSQK 275
PLN00026 PLN00026
aquaporin NIP; Provisional
 7-267 2.51e-20

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 89.15  E-value: 2.51e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164   7 IAFSRAVFAEFLATLLFVFFGLGSAL--NWPQALPSVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSFL 84
Cdd:PLN00026  68 VSLTRKLGAEFVGTFILIFAATAGPIvnQKYDGAETLIGNAACAGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPWK 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164  85 RATFYVAAQLLGAVAGAALLHEITPADIRGDLAVNALSnsttAGQAVTVELFLTLQLVLCIFA-STDERR-GENPGtpaL 162
Cdd:PLN00026 148 HVPAYIAAQVSASICASFALKGVFHPFMSGGVTVPSVS----TGQAFALEFIITFNLLFVVTAvATDTRAvGELAG---I 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164 163 SIGFSVALGHLLGvghghrfqppwrnrhtdhsrdrhrDPKrdtytelsrgtdtpeihyTGCSMNPARSLAPAVVTGKFDD 242
Cdd:PLN00026 221 AVGATVMLNILVA------------------------GPS------------------TGGSMNPVRTLGPAVAAGNYRA 258

                        250       260
                 ....*....|....*....|....*
gi 966972164 243 HWVFWIGPLVGAILGSLLYNYVLFP 267
Cdd:PLN00026 259 IWIYLVAPTLGALAGAGTYTAVKLR 283
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 2-268 2.68e-18

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 83.25  E-value: 2.68e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164   2 WELRSIAFS-RAVFAEFLATLLFVFFGLGSALNW--PQALPSVLQIAMAFGLG--IGTLVQAlgHISGAHINPAVTVA-C 75
Cdd:PTZ00016  41 WAPREYRPNvREYVAEFLGTFVLLFFGEGVVATThtVGNNGDYLAITIGWGLGvtFGLLVSA--GISGGHLNPAVTLGnA 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164  76 LVGChVSFLRATFYVAAQLLGAVAGAALLHEITPADIR---GDLAVNALSNSTTAG-----------QAVTVELFLTLQL 141
Cdd:PTZ00016 119 VFGK-FPWKKLPGYFVAQLLGAFVGAACVYGLYYGFFKdhgIPELPWETMANGFAGvfatypregnfYAIFSELILTAIL 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164 142 VLCIFASTDERRGENPGTPALSIGFSV-ALGHLLGVGhghrfqppwrnrhtdhsrdrhrdpkrdtytelsrgtdtpeihy 220
Cdd:PTZ00016 198 LLVILAITDPNNCPAFNYLPVAVGLLVfVIGISFGGN------------------------------------------- 234

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966972164 221 TGCSMNPARSLAP----AVVTGK--FD-DHWVFWI---GPLVGAILGSLLYNYVLFPP 268
Cdd:PTZ00016 235 TGYALNPARDLGPrlfsAILWGSevFTkDNYYFWVplvAPFVGAVLGMFLYDKFIPPL 292
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 10-107 7.29e-04

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 40.61  E-value: 7.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966972164  10 SRAVFAEFLATLLFVFfgLGSALNW-PQALPSVlqIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVgchVS--FLRA 86
Cdd:PLN00183 161 SSAFWVEFIATFIVMF--LAASLTSqPQSLGHL--SGFVIGIAIGLAVLITGPVSGGSMNPARSLGPAI---VSwdFKDI 233

                         90       100
                 ....*....|....*....|.
gi 966972164  87 TFYVAAQLLGAVAGAALLHEI 107
Cdd:PLN00183 234 WIYITAPTIGAVAGALMFHLL 254
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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