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Conserved domains on  [gi|1622843598|ref|XP_015006375|]
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amiloride-sensitive sodium channel subunit alpha isoform X3 [Macaca mulatta]

Protein Classification

epithelial sodium channel family protein( domain architecture ID 10017482)

epithelial sodium channel (ENaC) family protein acts as sodium channel transporter; similar to Homo sapiens acid-sensing ion channel 1 and amiloride-sensitive sodium channel subunits alpha/beta/gamma/delta

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ENaC TIGR00859
sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC ...
54-647 0e+00

sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the vertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


:

Pssm-ID: 273304 [Multi-domain]  Cd Length: 595  Bit Score: 964.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598  54 SYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTIC 133
Cdd:TIGR00859   1 SYRELLVWFCNNTTTHGAIRIVCSRGGRLKRALWALLTLLALALLLWQCGLLVRYYLSYPVSVSLSVNSDKLTFPAVTLC 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 134 TLNPYRYPEIKEELEELDRITQQTLFDLYKYDSSPTLVAGSRGR-RDLRGTLSHLLQRLRVPSPLHGaRQARSVASSVRD 212
Cdd:TIGR00859  81 NLNPYRYSKVKHLLEELDLETAQTLLSLYGYNSSLARSARSNNRnRIPLVVLDETLPRHPVPRDLFT-RQVHNKLISNRS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 213 NNPQVDWKDWKIGFELCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQA 292
Cdd:TIGR00859 160 NSPQVNASDWKVGFKLCNNNGSDCFYRTYTSGVQAVREWYRFHYINIFAQVPAEDKDRMGYQLEDFILTCRFDGESCDAR 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 293 NYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGVNNGLSLMLRTEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPG 372
Cdd:TIGR00859 240 NFTHFHHPMYGNCYTFNSGENSNLLTSSMPGAENGLKLVLDIEQDEYLPLLSTEAGARVMVHSQDEPPFIDDLGFGVRPG 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 373 VETSISMRKEALDRLGGDYGDCTKNGSDVPVKNLYPSKYTQQVCIHSCFQENMIKECGCAYIFYPRPQNMEYCDYRKHSS 452
Cdd:TIGR00859 320 TETSISMQEDELQRLGGPYGDCTENGSDVPVENLYNSSYSIQACLRSCFQRYMVENCGCAYYHYPLPGGAEYCNYEQHPD 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 453 WGYCYYKLQADFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFEMLSRQNNYTINNKRNGVAKVNIFFKELN 532
Cdd:TIGR00859 400 WAYCYYKLYAEFDQEELGCFSVCREPCNFTEYKLTLSMARWPSAASEDWLLHVLSRQNEYNITLIRNGIAKLNIFFEELN 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 533 YKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELIFDlLVITFLLLLRRFRSRYWSPGRGDRGAQEVASTQASS 612
Cdd:TIGR00859 480 YRTIEESPAYNVVTLLSNLGGQMGLWMGASVLCVLELLELIID-LIFITLLRLLWRFRKWWQRRRGPPYAEPPEPVSADT 558
                         570       580       590
                  ....*....|....*....|....*....|....*..
gi 1622843598 613 PPSHFCPHPTSLYLSQLGPAPSP--ALTAPPPAYATL 647
Cdd:TIGR00859 559 PPSLQLDDPPTFPSALPLPHASGlsLPGTPPPNYNTL 595
 
Name Accession Description Interval E-value
ENaC TIGR00859
sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC ...
54-647 0e+00

sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the vertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273304 [Multi-domain]  Cd Length: 595  Bit Score: 964.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598  54 SYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTIC 133
Cdd:TIGR00859   1 SYRELLVWFCNNTTTHGAIRIVCSRGGRLKRALWALLTLLALALLLWQCGLLVRYYLSYPVSVSLSVNSDKLTFPAVTLC 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 134 TLNPYRYPEIKEELEELDRITQQTLFDLYKYDSSPTLVAGSRGR-RDLRGTLSHLLQRLRVPSPLHGaRQARSVASSVRD 212
Cdd:TIGR00859  81 NLNPYRYSKVKHLLEELDLETAQTLLSLYGYNSSLARSARSNNRnRIPLVVLDETLPRHPVPRDLFT-RQVHNKLISNRS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 213 NNPQVDWKDWKIGFELCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQA 292
Cdd:TIGR00859 160 NSPQVNASDWKVGFKLCNNNGSDCFYRTYTSGVQAVREWYRFHYINIFAQVPAEDKDRMGYQLEDFILTCRFDGESCDAR 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 293 NYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGVNNGLSLMLRTEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPG 372
Cdd:TIGR00859 240 NFTHFHHPMYGNCYTFNSGENSNLLTSSMPGAENGLKLVLDIEQDEYLPLLSTEAGARVMVHSQDEPPFIDDLGFGVRPG 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 373 VETSISMRKEALDRLGGDYGDCTKNGSDVPVKNLYPSKYTQQVCIHSCFQENMIKECGCAYIFYPRPQNMEYCDYRKHSS 452
Cdd:TIGR00859 320 TETSISMQEDELQRLGGPYGDCTENGSDVPVENLYNSSYSIQACLRSCFQRYMVENCGCAYYHYPLPGGAEYCNYEQHPD 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 453 WGYCYYKLQADFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFEMLSRQNNYTINNKRNGVAKVNIFFKELN 532
Cdd:TIGR00859 400 WAYCYYKLYAEFDQEELGCFSVCREPCNFTEYKLTLSMARWPSAASEDWLLHVLSRQNEYNITLIRNGIAKLNIFFEELN 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 533 YKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELIFDlLVITFLLLLRRFRSRYWSPGRGDRGAQEVASTQASS 612
Cdd:TIGR00859 480 YRTIEESPAYNVVTLLSNLGGQMGLWMGASVLCVLELLELIID-LIFITLLRLLWRFRKWWQRRRGPPYAEPPEPVSADT 558
                         570       580       590
                  ....*....|....*....|....*....|....*..
gi 1622843598 613 PPSHFCPHPTSLYLSQLGPAPSP--ALTAPPPAYATL 647
Cdd:TIGR00859 559 PPSLQLDDPPTFPSALPLPHASGlsLPGTPPPNYNTL 595
ASC pfam00858
Amiloride-sensitive sodium channel;
62-572 8.78e-114

Amiloride-sensitive sodium channel;


Pssm-ID: 459966 [Multi-domain]  Cd Length: 439  Bit Score: 348.77  E-value: 8.78e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598  62 FCNNTTIHGaIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNIN--LNSDKLVFPAVTICTLNPYR 139
Cdd:pfam00858   1 FCENTSIHG-VRYIKSKDGFLRRLFWLLLFLASLIFLIYLISLLFEKYLSYPVITVIEeiLYVWNVPFPAVTICNLNPFR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 140 YPEIKEELEELDRITQQTLFDLYKYDSSPtlvagsrgrrdlrgtlshllqrlrvpsplhgarqarsvassvrdnnpqvdw 219
Cdd:pfam00858  80 YSALKELSLFYDNLSFLLYLKFKFLEKIL--------------------------------------------------- 108
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 220 kdwkigfelcnqnksdcFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFN--QVSCNqANYSHF 297
Cdd:pfam00858 109 -----------------KSLTSNTEELEDELKLLLDFTNELLNSLSGYILNLGLRCEDLIVSCSFGgeKEDCS-ANFTPI 170
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 298 HHpMYGNCYTFNDKNNSNLWMSSM---PGVNNGLSLMLRTEQND-FIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGV 373
Cdd:pfam00858 171 LT-EYGNCYTFNSKDNGSKLYPRRlkgAGSGRGLSLILNIQQSEtYSPLDYQAAGFKVSIHSPGEPPDVDKRGFSVPPGT 249
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 374 ETSISMRKEALDRLGGDYGDCTKNgsdvPVKNLYPSKYTQQVCIHSCFQENMIKECGCAYIFYPRPQNMeycdyrKHSSW 453
Cdd:pfam00858 250 ETSVGIQPTEITTLKRPYGNCTFD----DEKLLYFKSYSQSNCLLECRQNYILKLCGCVPFFYPLPPGT------KTGAD 319
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 454 GYCYYKLQADFSS--DHLGCFtKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFEMLSRQNNYTINNKRNGVAKVNIFFKEL 531
Cdd:pfam00858 320 IPCLLNYEDHLLEvnEGLSCQ-DCLPPCNETEYETEISYSTWPSLSSQLFLLYYELSTYNNSSSTIRENLAKLNIYFKEL 398
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|.
gi 1622843598 532 NYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAEL 572
Cdd:pfam00858 399 NYETYRRSPAYTWTDLLSSIGGQLGLFLGASVLSLVEIVYF 439
 
Name Accession Description Interval E-value
ENaC TIGR00859
sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC ...
54-647 0e+00

sodium channel transporter; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the vertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273304 [Multi-domain]  Cd Length: 595  Bit Score: 964.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598  54 SYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTIC 133
Cdd:TIGR00859   1 SYRELLVWFCNNTTTHGAIRIVCSRGGRLKRALWALLTLLALALLLWQCGLLVRYYLSYPVSVSLSVNSDKLTFPAVTLC 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 134 TLNPYRYPEIKEELEELDRITQQTLFDLYKYDSSPTLVAGSRGR-RDLRGTLSHLLQRLRVPSPLHGaRQARSVASSVRD 212
Cdd:TIGR00859  81 NLNPYRYSKVKHLLEELDLETAQTLLSLYGYNSSLARSARSNNRnRIPLVVLDETLPRHPVPRDLFT-RQVHNKLISNRS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 213 NNPQVDWKDWKIGFELCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFNQVSCNQA 292
Cdd:TIGR00859 160 NSPQVNASDWKVGFKLCNNNGSDCFYRTYTSGVQAVREWYRFHYINIFAQVPAEDKDRMGYQLEDFILTCRFDGESCDAR 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 293 NYSHFHHPMYGNCYTFNDKNNSNLWMSSMPGVNNGLSLMLRTEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPG 372
Cdd:TIGR00859 240 NFTHFHHPMYGNCYTFNSGENSNLLTSSMPGAENGLKLVLDIEQDEYLPLLSTEAGARVMVHSQDEPPFIDDLGFGVRPG 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 373 VETSISMRKEALDRLGGDYGDCTKNGSDVPVKNLYPSKYTQQVCIHSCFQENMIKECGCAYIFYPRPQNMEYCDYRKHSS 452
Cdd:TIGR00859 320 TETSISMQEDELQRLGGPYGDCTENGSDVPVENLYNSSYSIQACLRSCFQRYMVENCGCAYYHYPLPGGAEYCNYEQHPD 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 453 WGYCYYKLQADFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFEMLSRQNNYTINNKRNGVAKVNIFFKELN 532
Cdd:TIGR00859 400 WAYCYYKLYAEFDQEELGCFSVCREPCNFTEYKLTLSMARWPSAASEDWLLHVLSRQNEYNITLIRNGIAKLNIFFEELN 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 533 YKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAELIFDlLVITFLLLLRRFRSRYWSPGRGDRGAQEVASTQASS 612
Cdd:TIGR00859 480 YRTIEESPAYNVVTLLSNLGGQMGLWMGASVLCVLELLELIID-LIFITLLRLLWRFRKWWQRRRGPPYAEPPEPVSADT 558
                         570       580       590
                  ....*....|....*....|....*....|....*..
gi 1622843598 613 PPSHFCPHPTSLYLSQLGPAPSP--ALTAPPPAYATL 647
Cdd:TIGR00859 559 PPSLQLDDPPTFPSALPLPHASGlsLPGTPPPNYNTL 595
ASC pfam00858
Amiloride-sensitive sodium channel;
62-572 8.78e-114

Amiloride-sensitive sodium channel;


Pssm-ID: 459966 [Multi-domain]  Cd Length: 439  Bit Score: 348.77  E-value: 8.78e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598  62 FCNNTTIHGaIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNIN--LNSDKLVFPAVTICTLNPYR 139
Cdd:pfam00858   1 FCENTSIHG-VRYIKSKDGFLRRLFWLLLFLASLIFLIYLISLLFEKYLSYPVITVIEeiLYVWNVPFPAVTICNLNPFR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 140 YPEIKEELEELDRITQQTLFDLYKYDSSPtlvagsrgrrdlrgtlshllqrlrvpsplhgarqarsvassvrdnnpqvdw 219
Cdd:pfam00858  80 YSALKELSLFYDNLSFLLYLKFKFLEKIL--------------------------------------------------- 108
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 220 kdwkigfelcnqnksdcFYQTYSSGVDAVREWYRFHYINILSRLPETLPSLEEDTLGNFIFACRFN--QVSCNqANYSHF 297
Cdd:pfam00858 109 -----------------KSLTSNTEELEDELKLLLDFTNELLNSLSGYILNLGLRCEDLIVSCSFGgeKEDCS-ANFTPI 170
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 298 HHpMYGNCYTFNDKNNSNLWMSSM---PGVNNGLSLMLRTEQND-FIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGV 373
Cdd:pfam00858 171 LT-EYGNCYTFNSKDNGSKLYPRRlkgAGSGRGLSLILNIQQSEtYSPLDYQAAGFKVSIHSPGEPPDVDKRGFSVPPGT 249
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 374 ETSISMRKEALDRLGGDYGDCTKNgsdvPVKNLYPSKYTQQVCIHSCFQENMIKECGCAYIFYPRPQNMeycdyrKHSSW 453
Cdd:pfam00858 250 ETSVGIQPTEITTLKRPYGNCTFD----DEKLLYFKSYSQSNCLLECRQNYILKLCGCVPFFYPLPPGT------KTGAD 319
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 454 GYCYYKLQADFSS--DHLGCFtKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFEMLSRQNNYTINNKRNGVAKVNIFFKEL 531
Cdd:pfam00858 320 IPCLLNYEDHLLEvnEGLSCQ-DCLPPCNETEYETEISYSTWPSLSSQLFLLYYELSTYNNSSSTIRENLAKLNIYFKEL 398
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|.
gi 1622843598 532 NYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAEL 572
Cdd:pfam00858 399 NYETYRRSPAYTWTDLLSSIGGQLGLFLGASVLSLVEIVYF 439
deg-1 TIGR00867
degenerin; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of ...
62-572 1.38e-66

degenerin; The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the invertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273309 [Multi-domain]  Cd Length: 600  Bit Score: 229.73  E-value: 1.38e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598  62 FCNNTTIHGaIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEYFSYPVSLNINLNSDKLVFPAVTICTLNPYRY- 140
Cdd:TIGR00867   2 FCYKTTFHG-IPMVATASNSFSRAFWVALFLICLLMFAYQAYILISKYFQYEKIVDIQLKFETAPFPAITVCNLNPYKYs 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 141 -----PEIKEELEELDRITQQTlfdlykyDSSPTLVAGSRGRRDLRGTLSHLLQRLRVPSPLHGAR------------QA 203
Cdd:TIGR00867  81 lvrsvPEISETLDAFDRAIGAS-------NKSEGDELELITERKLHSKTRRQKLKAKGAPELEDGMyepvfsqctcdeQG 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 204 RSVASSVRDNNPQVD-----------------------WKDWKIGfeLCNQN--------------KSDCFYQTYS---- 242
Cdd:TIGR00867 154 MGECKSQRSAEPRGHtsrcicaydrvtgdawpcfpystWTTKKCS--LCNDNgfcpkpnkkgakeqKDPCLCQSESnhcv 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 243 --SGVDAVREWYRFHYINILSRLPETLPSLEED---------------------------------------TLGNFIFA 281
Cdd:TIGR00867 232 shPGKGIIREIWPNLENNDPTTGKPTTEAPETLealgfgnmtdevaittqakenlifamaalsdkarealsyTKHELILK 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 282 CRFNQVSCN-QANYSHFHHPMYGNCYTFNDKNNSNLwMSSMPGVNNGLSLMLRTEQNDFIPLlSTVTGARVMVHGQDEPA 360
Cdd:TIGR00867 312 CSFNGKPCDiDRDFTLHIDPVFGNCYTFNYNRSVNL-SSSRAGPMYGLRLLLFVNQSDYLPT-TEAAGVRLTIHDKDEFP 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 361 FMDDGGFNLRPGVETSISMRKEALDRLGGDYGDCTKNGSDVP-VKNLYpsKYTQQVCIHSCFQENMIKECGCAYIFYPRP 439
Cdd:TIGR00867 390 FPDTFGYSAPTGYISSFGVRLKQMSRLPAPYGNCVDTGKDSSyIYKGY--IYSPEGCHRSCFQRLIIAKCGCADPRFPVP 467
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622843598 440 QNMEYCD---------YRKHSSWgycyyklQADFSSDHLGCftKCRKPCSVTSYQLSAGYSRWPSvTSQEWVFEMLSRQN 510
Cdd:TIGR00867 468 EGTRHCQafnktdrecLETLTGD-------LGELHHSIFKC--RCQQPCQESIYTTTYSAAKWPS-GSLKITLGSCDSNT 537
                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622843598 511 NYTINNK-RNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWSLWFGSSVLSVVEMAEL 572
Cdd:TIGR00867 538 ASECNEYyRENAAMIEVFYEQLNYELLTESEAYTLVNLIADFGGQLGLWLGASVITVCEFVFL 600
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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