NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|966970257|ref|XP_015006233|]
View 

leucine-rich repeat and transmembrane domain-containing protein 2 isoform X1 [Macaca mulatta]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-199 1.48e-18

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 1.48e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966970257  51 EVDCSGLGLTTVPPDVPAAT--RTLLLLNNKLSALPSWaFANLSSLQRLDLSNNFLDQLPHSIfGDLTNLTELQLRNNSI 128
Cdd:COG4886  140 ELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGNQL 217

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966970257 129 RTLDRDlLRHAPLLRHLDLSINGLAQLPpglfdgllalrsLSLRSNRLQNLD----RLTFEP----LANLQLLQVGDNP 199
Cdd:COG4886  218 TDLPEP-LANLTNLETLDLSNNQLTDLP------------ELGNLTNLEELDlsnnQLTDLPplanLTNLKTLDLSNNQ 283
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 174-261 3.30e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 46.23  E-value: 3.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966970257   174 NRLQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWMEWFSYRGGRLDQLACTLPKELRGKDMRMVPMEM----FNY 249
Cdd:TIGR00864    5 NKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPLLDsgcdEEY 84

                           90
                   ....*....|..
gi 966970257   250 CSQLEDENSSAG 261
Cdd:TIGR00864   85 VACLKDNSSGGG 96
PHA03264 super family cl42984
envelope glycoprotein D; Provisional
 265-335 2.32e-03

envelope glycoprotein D; Provisional


The actual alignment was detected with superfamily member PHA03264:

Pssm-ID: 223029 [Multi-domain]  Cd Length: 416  Bit Score: 39.60  E-value: 2.32e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966970257 265 PGPPCTKASPEPAKPksgAEPEPEPSTACPQKQRHRPASVrramGTVIIAGVvcgivcIMMVVAAAYGCIY 335
Cdd:PHA03264 328 PAPDADRPEGWPSLE---AITFPPPTPATPAVPRARPVIV----GTGIAAAA------IACVAAAGAVAYF 385
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-199 1.48e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 1.48e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966970257  51 EVDCSGLGLTTVPPDVPAAT--RTLLLLNNKLSALPSWaFANLSSLQRLDLSNNFLDQLPHSIfGDLTNLTELQLRNNSI 128
Cdd:COG4886  140 ELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGNQL 217

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966970257 129 RTLDRDlLRHAPLLRHLDLSINGLAQLPpglfdgllalrsLSLRSNRLQNLD----RLTFEP----LANLQLLQVGDNP 199
Cdd:COG4886  218 TDLPEP-LANLTNLETLDLSNNQLTDLP------------ELGNLTNLEELDlsnnQLTDLPplanLTNLKTLDLSNNQ 283
LRR_8 pfam13855
Leucine rich repeat;
92-152 9.84e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.24  E-value: 9.84e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966970257   92 SSLQRLDLSNNFLDQLPHSIFGDLTNLTELQLRNNSIRTLDRDLLRHAPLLRHLDLSINGL 152
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
57-202 1.91e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 56.24  E-value: 1.91e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966970257  57 LGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQrldLSNNFLDQLPHSIfGDLTNLTELQlRNNSIrtldrDLL 136
Cdd:PRK15370 188 LGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLY---ANSNQLTSIPATL-PDTIQEMELS-INRIT-----ELP 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966970257 137 RHAP-LLRHLDLSINGLAQLPPGLFDGllaLRSLSLRSNRLQNL---------------DRLTFEPLA---NLQLLQVGD 197
Cdd:PRK15370 258 ERLPsALQSLDLFHNKISCLPENLPEE---LRYLSVYDNSIRTLpahlpsgithlnvqsNSLTALPETlppGLKTLEAGE 334


                 ....*
gi 966970257 198 NPWEC 202
Cdd:PRK15370 335 NALTS 339
LRRNT smart00013
Leucine rich repeat N-terminal domain;
39-70 9.12e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.92  E-value: 9.12e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 966970257    39 CPFSCKCdsRSLEVDCSGLGLTTVPPDVPAAT 70
Cdd:smart00013   2 CPAPCNC--SGTAVDCSGRGLTEVPLDLPPDT 31
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 93-156 3.17e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.78  E-value: 3.17e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966970257  93 SLQRLDLSNNFLDQLphSIFGDLTNLTELQLRNNSIRTLDR--DLLRHAPLLRHLDLSINGLAQLP 156
Cdd:cd21340  121 SLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 174-261 3.30e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 46.23  E-value: 3.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966970257   174 NRLQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWMEWFSYRGGRLDQLACTLPKELRGKDMRMVPMEM----FNY 249
Cdd:TIGR00864    5 NKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPLLDsgcdEEY 84

                           90
                   ....*....|..
gi 966970257   250 CSQLEDENSSAG 261
Cdd:TIGR00864   85 VACLKDNSSGGG 96
LRRCT smart00082
Leucine rich repeat C-terminal domain;
198-237 5.03e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 37.79  E-value: 5.03e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 966970257   198 NPWECDCNLREFKHWMEWFSYRGGRLDqLACTLPKELRGK 237
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVD-LRCASPSSLRGP 39
PHA03264 PHA03264
envelope glycoprotein D; Provisional
 265-335 2.32e-03

envelope glycoprotein D; Provisional


Pssm-ID: 223029 [Multi-domain]  Cd Length: 416  Bit Score: 39.60  E-value: 2.32e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966970257 265 PGPPCTKASPEPAKPksgAEPEPEPSTACPQKQRHRPASVrramGTVIIAGVvcgivcIMMVVAAAYGCIY 335
Cdd:PHA03264 328 PAPDADRPEGWPSLE---AITFPPPTPATPAVPRARPVIV----GTGIAAAA------IACVAAAGAVAYF 385
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-199 1.48e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 1.48e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966970257  51 EVDCSGLGLTTVPPDVPAAT--RTLLLLNNKLSALPSWaFANLSSLQRLDLSNNFLDQLPHSIfGDLTNLTELQLRNNSI 128
Cdd:COG4886  140 ELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGNQL 217

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966970257 129 RTLDRDlLRHAPLLRHLDLSINGLAQLPpglfdgllalrsLSLRSNRLQNLD----RLTFEP----LANLQLLQVGDNP 199
Cdd:COG4886  218 TDLPEP-LANLTNLETLDLSNNQLTDLP------------ELGNLTNLEELDlsnnQLTDLPplanLTNLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
71-198 3.11e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.29  E-value: 3.11e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966970257  71 RTLLLLNNKLSALPsWAFANLSSLQRLDLSNNFLDQLPHSIfGDLTNLTELQLRNNSIRTLDRDLLRhAPLLRHLDLSIN 150
Cdd:COG4886  116 ESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLPEPL-GNLTNLKSLDLSNNQLTDLPEELGN-LTNLKELDLSNN 192

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966970257 151 GLAQLPPGLFDgllalrslslrSNRLQNLD----RLT-----FEPLANLQLLQVGDN 198
Cdd:COG4886  193 QITDLPEPLGN-----------LTNLEELDlsgnQLTdlpepLANLTNLETLDLSNN 238
LRR_8 pfam13855
Leucine rich repeat;
92-152 9.84e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.24  E-value: 9.84e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966970257   92 SSLQRLDLSNNFLDQLPHSIFGDLTNLTELQLRNNSIRTLDRDLLRHAPLLRHLDLSINGL 152
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
87-198 3.73e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.35  E-value: 3.73e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966970257  87 AFANLSSLQRLDLSNNFLDQLPHSIfGDLTNLTELQLRNNSIRTLDRDlLRHAPLLRHLDLSINGLAQLPPGLFDgllal 166
Cdd:COG4886  108 ELSNLTNLESLDLSGNQLTDLPEEL-ANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEELGN----- 180

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 966970257 167 rslslrSNRLQNLD----RLTFEP-----LANLQLLQVGDN 198
Cdd:COG4886  181 ------LTNLKELDlsnnQITDLPeplgnLTNLEELDLSGN 215
LRR_8 pfam13855
Leucine rich repeat;
71-128 5.37e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.84  E-value: 5.37e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 966970257   71 RTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDQL-PHSiFGDLTNLTELQLRNNSI 128
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGA-FSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
57-202 1.91e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 56.24  E-value: 1.91e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966970257  57 LGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQrldLSNNFLDQLPHSIfGDLTNLTELQlRNNSIrtldrDLL 136
Cdd:PRK15370 188 LGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLY---ANSNQLTSIPATL-PDTIQEMELS-INRIT-----ELP 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966970257 137 RHAP-LLRHLDLSINGLAQLPPGLFDGllaLRSLSLRSNRLQNL---------------DRLTFEPLA---NLQLLQVGD 197
Cdd:PRK15370 258 ERLPsALQSLDLFHNKISCLPENLPEE---LRYLSVYDNSIRTLpahlpsgithlnvqsNSLTALPETlppGLKTLEAGE 334


                 ....*
gi 966970257 198 NPWEC 202
Cdd:PRK15370 335 NALTS 339
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
59-159 8.19e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.85  E-value: 8.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966970257  59 LTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQRLDlsnNFLDQLPHSIFGDLTNLTelqLRNNSIRTLDRDLlrh 138
Cdd:PRK15370 295 IRTLPAHLPSGITHLNVQSNSLTALPETLPPGLKTLEAGE---NALTSLPASLPPELQVLD---VSKNQITVLPETL--- 365

                         90       100
                 ....*....|....*....|.
gi 966970257 139 APLLRHLDLSINGLAQLPPGL 159
Cdd:PRK15370 366 PPTITTLDVSRNALTNLPENL 386
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
51-159 1.02e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.85  E-value: 1.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966970257  51 EVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSwafaNL-SSLQRLDLSNNFLDQLPHSIfgdLTNLTELQLRNNSIR 129
Cdd:PRK15370 245 EMELSINRITELPERLPSALQSLDLFHNKISCLPE----NLpEELRYLSVYDNSIRTLPAHL---PSGITHLNVQSNSLT 317

                         90       100       110
                 ....*....|....*....|....*....|
gi 966970257 130 TLDRDLlrhAPLLRHLDLSINGLAQLPPGL 159
Cdd:PRK15370 318 ALPETL---PPGLKTLEAGENALTSLPASL 344
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 39-67 6.97e-06

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 42.23  E-value: 6.97e-06
                          10        20
                  ....*....|....*....|....*....
gi 966970257   39 CPFSCKCdsRSLEVDCSGLGLTTVPPDVP 67
Cdd:pfam01462   2 CPVPCHC--SATVVNCSDRGLTAVPRDLP 28
LRRNT smart00013
Leucine rich repeat N-terminal domain;
39-70 9.12e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.92  E-value: 9.12e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 966970257    39 CPFSCKCdsRSLEVDCSGLGLTTVPPDVPAAT 70
Cdd:smart00013   2 CPAPCNC--SGTAVDCSGRGLTEVPLDLPPDT 31
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 93-156 3.17e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.78  E-value: 3.17e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966970257  93 SLQRLDLSNNFLDQLphSIFGDLTNLTELQLRNNSIRTLDR--DLLRHAPLLRHLDLSINGLAQLP 156
Cdd:cd21340  121 SLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 174-261 3.30e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 46.23  E-value: 3.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966970257   174 NRLQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWMEWFSYRGGRLDQLACTLPKELRGKDMRMVPMEM----FNY 249
Cdd:TIGR00864    5 NKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPLLDsgcdEEY 84

                           90
                   ....*....|..
gi 966970257   250 CSQLEDENSSAG 261
Cdd:TIGR00864   85 VACLKDNSSGGG 96
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 72-198 4.62e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.01  E-value: 4.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966970257  72 TLLLLNNK-LSALPswAFANLSSLQRLDLSNNFLDQLPHsiFGDLTNLTELQLRNNSIRTLDRdlLRHAPLLRHLDLS-- 148
Cdd:cd21340    5 THLYLNDKnITKID--NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGgn 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966970257 149 ----INGLA-------------QLPPG---LFDgllaLRSLSLRSNRLQNLD----RLT----FEPLANLQLLQVGDN 198
Cdd:cd21340   79 risvVEGLEnltnleelhienqRLPPGeklTFD----PRSLAALSNSLRVLNisgnNIDslepLAPLRNLEQLDASNN 152
LRR_8 pfam13855
Leucine rich repeat;
116-199 1.08e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966970257  116 TNLTELQLRNNSIRTLDRDLLRHAPLLRHLDLsinglaqlppglfdgllalrslslRSNRLQNLDRLTFEPLANLQLLQV 195
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDL------------------------SNNLLTTLSPGAFSGLPSLRYLDL 56


                  ....
gi 966970257  196 GDNP 199
Cdd:pfam13855  57 SGNR 60
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 93-132 1.75e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.77  E-value: 1.75e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 966970257   93 SLQRLDLSNNFLDQLPhsIFGDLTNLTELQL-RNNSIRTLD 132
Cdd:pfam12799   2 NLEVLDLSNNQITDIP--PLAKLPNLETLDLsGNNKITDLS 40
PLN03150 PLN03150
hypothetical protein; Provisional
 42-128 3.47e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.50  E-value: 3.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966970257  42 SCKCDSRSLEVDCSGLGLTT------VPPDVPAAT--RTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLD-QLPHSIf 112
Cdd:PLN03150 408 DCQFDSTKGKWFIDGLGLDNqglrgfIPNDISKLRhlQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIPESL- 486

                         90
                 ....*....|....*.
gi 966970257 113 GDLTNLTELQLRNNSI 128
Cdd:PLN03150 487 GQLTSLRILNLNGNSL 502
LRRCT smart00082
Leucine rich repeat C-terminal domain;
198-237 5.03e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 37.79  E-value: 5.03e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 966970257   198 NPWECDCNLREFKHWMEWFSYRGGRLDqLACTLPKELRGK 237
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVD-LRCASPSSLRGP 39
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 71-128 8.60e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 8.60e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966970257  71 RTLLLLN---NKLSALpsWAFANLSSLQRLDLSNNFLDQLPH--SIFGDLTNLTELQLRNNSI 128
Cdd:cd21340  120 NSLRVLNisgNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPV 180
PHA03264 PHA03264
envelope glycoprotein D; Provisional
 265-335 2.32e-03

envelope glycoprotein D; Provisional


Pssm-ID: 223029 [Multi-domain]  Cd Length: 416  Bit Score: 39.60  E-value: 2.32e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966970257 265 PGPPCTKASPEPAKPksgAEPEPEPSTACPQKQRHRPASVrramGTVIIAGVvcgivcIMMVVAAAYGCIY 335
Cdd:PHA03264 328 PAPDADRPEGWPSLE---AITFPPPTPATPAVPRARPVIV----GTGIAAAA------IACVAAAGAVAYF 385
LRR smart00370
Leucine-rich repeats, outliers;
91-114 2.45e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 2.45e-03
                           10        20
                   ....*....|....*....|....
gi 966970257    91 LSSLQRLDLSNNFLDQLPHSIFGD 114
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
91-114 2.45e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 2.45e-03
                           10        20
                   ....*....|....*....|....
gi 966970257    91 LSSLQRLDLSNNFLDQLPHSIFGD 114
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 55-152 2.49e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 2.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966970257  55 SGLGLTTVPPDVPAATRTLLLLNNKLSALPSW-----AFANLSSLQRLDLSNN-FLDQLPHSIFGDLTN--LTELQLRNN 126
Cdd:cd00116   39 AAKALASALRPQPSLKELCLSLNETGRIPRGLqsllqGLTKGCGLQELDLSDNaLGPDGCGVLESLLRSssLQELKLNNN 118

                         90       100       110
                 ....*....|....*....|....*....|.
gi 966970257 127 SI-----RTLDRDLLRHAPLLRHLDLSINGL 152
Cdd:cd00116  119 GLgdrglRLLAKGLKDLPPALEKLVLGRNRL 149
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-201 3.21e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.15  E-value: 3.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966970257  69 ATRTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDQLPHSIFGDLTNLTELQLRNN-------SIRTLD------RDL 135
Cdd:COG4886   49 LTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNeelsnltNLESLDlsgnqlTDL 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966970257 136 ---LRHAPLLRHLDLSINGLAQLPPGLFDgllalrslslrsnrLQNLDRL------------TFEPLANLQLLQVGDNPW 200
Cdd:COG4886  129 peeLANLTNLKELDLSNNQLTDLPEPLGN--------------LTNLKSLdlsnnqltdlpeELGNLTNLKELDLSNNQI 194


                 .
gi 966970257 201 E 201
Cdd:COG4886  195 T 195
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 116-150 3.49e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 3.49e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 966970257  116 TNLTELQLRNNSIRTLdrDLLRHAPLLRHLDLSIN 150
Cdd:pfam12799   1 PNLEVLDLSNNQITDI--PPLAKLPNLETLDLSGN 33
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 71-201 4.24e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.06  E-value: 4.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966970257  71 RTLLLLNNKLSA-LPSWAFANLSSLQRLDLS-NNFLDQLPHsifGDLTNLTELQLRNNSIRTLDRDLLRHAPLLRHLDLS 148
Cdd:PLN00113  96 QTINLSNNQLSGpIPDDIFTTSSSLRYLNLSnNNFTGSIPR---GSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLG 172

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 966970257 149 INGLAQLPPglfdgllalrslslrsNRLQNLDRLTFEPLANLQLlqVGDNPWE 201
Cdd:PLN00113 173 GNVLVGKIP----------------NSLTNLTSLEFLTLASNQL--VGQIPRE 207
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
71-193 4.65e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 38.76  E-value: 4.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966970257  71 RTLLLLNNKLSALPSwaFANLSSLQRLDLSNNFLDQLPHSIFGDLTNLTELQLRNNSIRTLDRDLLRHAPLLRHLDLSIN 150
Cdd:COG4886  253 EELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLL 330

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 966970257 151 GLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLL 193
Cdd:COG4886  331 KGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 71-109 5.28e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 5.28e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 966970257   71 RTLLLLNNKLSALPswAFANLSSLQRLDLS-NNFLDQLPH 109
Cdd:pfam12799   4 EVLDLSNNQITDIP--PLAKLPNLETLDLSgNNKITDLSD 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH