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Conserved domains on  [gi|1622838129|ref|XP_015005776|]
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cdc42 effector protein 1 [Macaca mulatta]

Protein Classification

CRIB and BORG_CEP domain-containing protein( domain architecture ID 10210576)

CRIB and BORG_CEP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BORG_CEP pfam14957
Cdc42 effector; The Cdc42 effector (CEP) or binder of Rho GTPases (BORG) proteins are involved ...
 117-215 1.19e-16

Cdc42 effector; The Cdc42 effector (CEP) or binder of Rho GTPases (BORG) proteins are involved in the organization of the actin cytoskeleton. They may function as negative regulators of Rho GTPase signaling.


:

Pssm-ID: 464403  Cd Length: 121  Bit Score: 75.59  E-value: 1.19e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838129 117 KNAISLPQLNQAAYDSLVVGKL-----SFDGSPSSS-------MDGHSSYGLDSGFCTISRLPRSEKPHDRDRDGS---- 180
Cdd:pfam14957   3 KNAISLPQLNEGGSQALTLPKLppkppREPKSLSSSpekkslyEDGPRADSTNSAPLESPTEKLSERSFGSLTDLSsesp 82

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1622838129 181 ----FPSEPGLRRSDSLLSFrlDLDLGPSLLSELLGVMS 215
Cdd:pfam14957  83 kysdRSESPGLKRAESLLSL--HLDLGPSILGDVLSIMD 119
CRIB super family cl00113
PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; ...
 37-64 6.49e-06

PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the Ras-Rac pathway. CRIB-containing effector proteins are functionally diverse and include serine/threonine kinases, tyrosine kinases, actin-binding proteins, and adapter molecules.


The actual alignment was detected with superfamily member pfam00786:

Pssm-ID: 412170  Cd Length: 59  Bit Score: 43.07  E-value: 6.49e-06
                          10        20
                  ....*....|....*....|....*...
gi 1622838129  37 MISPPlGDFRHTMHVGRGGDVFGDTSFL 64
Cdd:pfam00786   1 MISAP-TNFKHTVHVGFDPDTGFFTGLP 27
 
Name Accession Description Interval E-value
BORG_CEP pfam14957
Cdc42 effector; The Cdc42 effector (CEP) or binder of Rho GTPases (BORG) proteins are involved ...
 117-215 1.19e-16

Cdc42 effector; The Cdc42 effector (CEP) or binder of Rho GTPases (BORG) proteins are involved in the organization of the actin cytoskeleton. They may function as negative regulators of Rho GTPase signaling.


Pssm-ID: 464403  Cd Length: 121  Bit Score: 75.59  E-value: 1.19e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838129 117 KNAISLPQLNQAAYDSLVVGKL-----SFDGSPSSS-------MDGHSSYGLDSGFCTISRLPRSEKPHDRDRDGS---- 180
Cdd:pfam14957   3 KNAISLPQLNEGGSQALTLPKLppkppREPKSLSSSpekkslyEDGPRADSTNSAPLESPTEKLSERSFGSLTDLSsesp 82

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1622838129 181 ----FPSEPGLRRSDSLLSFrlDLDLGPSLLSELLGVMS 215
Cdd:pfam14957  83 kysdRSESPGLKRAESLLSL--HLDLGPSILGDVLSIMD 119
PBD pfam00786
P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also ...
 37-64 6.49e-06

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).


Pssm-ID: 395634  Cd Length: 59  Bit Score: 43.07  E-value: 6.49e-06
                          10        20
                  ....*....|....*....|....*...
gi 1622838129  37 MISPPlGDFRHTMHVGRGGDVFGDTSFL 64
Cdd:pfam00786   1 MISAP-TNFKHTVHVGFDPDTGFFTGLP 27
PBD smart00285
P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also ...
 38-71 1.61e-03

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).


Pssm-ID: 197628  Cd Length: 36  Bit Score: 35.65  E-value: 1.61e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1622838129   38 ISPPLgDFRHTMHVGRGG--DVFGDTSFLSNHGGSS 71
Cdd:smart00285   1 ISTPT-NFKHIAHVGFDGqtGGFTGLPTEWKSLLKT 35
 
Name Accession Description Interval E-value
BORG_CEP pfam14957
Cdc42 effector; The Cdc42 effector (CEP) or binder of Rho GTPases (BORG) proteins are involved ...
 117-215 1.19e-16

Cdc42 effector; The Cdc42 effector (CEP) or binder of Rho GTPases (BORG) proteins are involved in the organization of the actin cytoskeleton. They may function as negative regulators of Rho GTPase signaling.


Pssm-ID: 464403  Cd Length: 121  Bit Score: 75.59  E-value: 1.19e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838129 117 KNAISLPQLNQAAYDSLVVGKL-----SFDGSPSSS-------MDGHSSYGLDSGFCTISRLPRSEKPHDRDRDGS---- 180
Cdd:pfam14957   3 KNAISLPQLNEGGSQALTLPKLppkppREPKSLSSSpekkslyEDGPRADSTNSAPLESPTEKLSERSFGSLTDLSsesp 82

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1622838129 181 ----FPSEPGLRRSDSLLSFrlDLDLGPSLLSELLGVMS 215
Cdd:pfam14957  83 kysdRSESPGLKRAESLLSL--HLDLGPSILGDVLSIMD 119
PBD pfam00786
P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also ...
 37-64 6.49e-06

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).


Pssm-ID: 395634  Cd Length: 59  Bit Score: 43.07  E-value: 6.49e-06
                          10        20
                  ....*....|....*....|....*...
gi 1622838129  37 MISPPlGDFRHTMHVGRGGDVFGDTSFL 64
Cdd:pfam00786   1 MISAP-TNFKHTVHVGFDPDTGFFTGLP 27
PBD smart00285
P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also ...
 38-71 1.61e-03

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).


Pssm-ID: 197628  Cd Length: 36  Bit Score: 35.65  E-value: 1.61e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1622838129   38 ISPPLgDFRHTMHVGRGG--DVFGDTSFLSNHGGSS 71
Cdd:smart00285   1 ISTPT-NFKHIAHVGFDGqtGGFTGLPTEWKSLLKT 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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