BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17); KCTD17 is a BTB/POZ domain-containing protein that functions as a substrate-adaptor for cullin3-RING ubiquitin ligases that polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD17 BTB domains form pentamers.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265  31 KWVRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEELQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVLE 110
Cdd:cd18391    1 KWVRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEELQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVLE 80

                         90       100
                 ....*....|....*....|.
gi 966969265 111 EAEFYNIGPLIRIIKDRMEEK 131
Cdd:cd18391   81 EAEFYNIGPLIRIIKDRMEEK 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17); KCTD17 is a BTB/POZ domain-containing protein that functions as a substrate-adaptor for cullin3-RING ubiquitin ligases that polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD17 BTB domains form pentamers.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265  31 KWVRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEELQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVLE 110
Cdd:cd18391    1 KWVRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEELQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVLE 80

                         90       100
                 ....*....|....*....|.
gi 966969265 111 EAEFYNIGPLIRIIKDRMEEK 131
Cdd:cd18391   81 EAEFYNIGPLIRIIKDRMEEK 101

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265    32 WVRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEElqsDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEgVLEE 111
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFK---ESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEE-LLEL 76

                           90       100
                   ....*....|....*....|
gi 966969265   112 AEFYNIGPLIRIIKDRMEEK 131
Cdd:smart00225  77 ADYLQIPGLVELCEEFLLKL 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17); KCTD17 is a BTB/POZ domain-containing protein that functions as a substrate-adaptor for cullin3-RING ubiquitin ligases that polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD17 BTB domains form pentamers.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265  31 KWVRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEELQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVLE 110
Cdd:cd18391    1 KWVRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEELQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVLE 80

                         90       100
                 ....*....|....*....|.
gi 966969265 111 EAEFYNIGPLIRIIKDRMEEK 131
Cdd:cd18391   81 EAEFYNIGPLIRIIKDRMEEK 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 5 (KCTD5); KCTD5 is a BTB/POZ domain-containing protein that functions as a substrate adaptor for cullin3 based ubiquitin E3 ligases. It is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 forms pentamers mediated by its BTB domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265  31 KWVRLNVGGTVFLTTRQTLCREQKSFLSRLCQGE-ELQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVL 109
Cdd:cd18390    5 KWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADpDLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVL 84

                         90       100
                 ....*....|....*....|....*...
gi 966969265 110 EEAEFYNIGPLIRIIKDRMEEKDYTVTQ 137
Cdd:cd18390   85 EEAEFYNITSLIKLVKDKIRERDSKTSQ 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins; This family includes two protein groups: voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins. Kv channels are membrane proteins with fundamental physiological roles. They are responsible for a variety of electrical phenomena, such as the repolarization of the action potential, spike frequency adaptation, synaptic repolarization, and smooth muscle contraction. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels, and others. All family members contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265  33 VRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEELQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVLEEA 112
Cdd:cd18187    1 VVLNVSGTRFVTNRQTLTRHPDTLLGRMFKPGREFTFPNETGEYFIDRDPTVFRTILNYYRTGKLNCPDGISIPDLREEC 80

                 ...
gi 966969265 113 EFY 115
Cdd:cd18187   81 DFY 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265  33 VRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEELQSdRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAE-EGVLEE 111
Cdd:cd18316    1 VKLNVGGTLFTTSRSTLLKDPDSLLAALFSGRWPLP-RDEDGSIFIDRDPELFRHILNFLRTGKLPLPSDFVElEELLAE 79

                 ....
gi 966969265 112 AEFY 115
Cdd:cd18316   80 AEFY 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 7 (KCTD7); KCTD7 is a BTB/POZ domain-containing protein that has an impact on K+ fluxes, neurotransmitter synthesis, and neuronal function. It functions as a regulator of potassium conductance in neurons, and is involved in the control of excitability of cortical neurons. Mutations in KCTD7 may cause progressive myoclonus epilepsy (PME). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265  33 VRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEElQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVlDKDMAEEgVLEEA 112
Cdd:cd18366    6 VPLNVGGMHFTTRLSTLRKYEDSMLAAMFSGRH-HIPKDSEGRYFIDRDGSYFGYILNFLRDGDLP-PRERARA-VYKEA 82

                 ....*....
gi 966969265 113 EFYNIGPLI 121
Cdd:cd18366   83 QYYGIGPLI 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3); KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265  33 VRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEeLQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVLdKDMAEEGVLEEA 112
Cdd:cd18392    4 IQLNVGGTRFSTSRQTLMWIPDSFFSSLLSGR-ISSLKDETGAIFIDRDPTAFVPILNFLRTKELDL-RGVNINVLRHEA 81

                 ....*..
gi 966969265 113 EFYNIGP 119
Cdd:cd18392   82 EFYGITP 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1); SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265  33 VRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEeLQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVLdKDMAEEGVLEEA 112
Cdd:cd18393    4 IHLNVGGKRFSTSRQTLTWIPDSFFSSLLSGR-ISTLKDETGAIFIDRDPTVFAPILNFLRTKELDP-RGIHVSLLLHEA 81

                         90
                 ....*....|....*..
gi 966969265 113 EFYNIGPLIRIIKDRME 129
Cdd:cd18393   82 QFYGITPLVRRLQLCEE 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 4 (KCTD4); KCTD4 is a BTB/POZ domain-containing protein with an unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265  33 VRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEeLQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVLE-E 111
Cdd:cd18364    2 VTLNVGGYLYITQRQTLTKYPDSFLEGMVNGK-IQCTVDADGNYFIDRDGLLFRHVLNFLRNGELLLPEGFQENQLLAlE 80

                 ....*.
gi 966969265 112 AEFYNI 117
Cdd:cd18364   81 ADFYQL 86

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265    32 WVRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEElqsDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEgVLEE 111
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFK---ESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEE-LLEL 76

                           90       100
                   ....*....|....*....|
gi 966969265   112 AEFYNIGPLIRIIKDRMEEK 131
Cdd:smart00225  77 ADYLQIPGLVELCEEFLLKL 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD8, KCTD12, KCTD16 and similar proteins; This subfamily of KCTD proteins includes KCTD8, KCTD12 (also called predominantly fetal expressed T1 domain/Pfetin), and KCTD16. They act as auxiliary subunits of GABAB receptors associated with mood disorders. KCTD8 interacts as a tetramer with GABRB1 and GABRB2. KCTD12 regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. KCTD16 interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion, and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265  33 VRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEELQS-DRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAE-EGVLE 110
Cdd:cd18367    5 VELNVGGQVYTTSLSTLIKDPDSLLGRMFSGKNRQElARDSKGRYFLDRDGVLFRYILDYLRNQKLVLPENFPErERLKR 84

                         90
                 ....*....|....*
gi 966969265 111 EAEFYNIGPLIRIIK 125
Cdd:cd18367   85 EAEYFQLPELVKALR 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD1 and KCTD15; This subfamily of KCTD proteins includes KCTD1 and KCTD15. KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265  33 VRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEE---LQSDRDEtgaYLIDRDPTYFGPILNFLRHGKLVLDKDMAE-EGV 108
Cdd:cd18361    1 VHIDVGGHIYTSSLETLTKYPESRLGKLFNGSIpivLDSLKQH---YFIDRDGKMFRHILNFLRTSKLLLPDDFTEfDLL 77

                         90
                 ....*....|....*..
gi 966969265 109 LEEAEFYNIGPLIRIIK 125
Cdd:cd18361   78 YEEARYYELQPMVKQLE 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD11; KCTD11 may function as an antagonist of the Hedgehog pathway of cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in the undifferentiated state. It is a probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. It contains a BTB/POZ domain; in some cases the domain may be truncated. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. Variants of the human/mouse KCTD11 appear to contain truncated BTB/POZ domains.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265  33 VRLNVGGTVFLTTRQTLCREQKSFLSRLCQG---EELQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVL 109
Cdd:cd18370    1 VTLNVGGTLYSTTLETLTRFPDSMLGAMFRAgtpIPPNLNMQGGGHYFIDRDGKAFRHILNFLRLGRLDLPRGYGETALL 80

                 ....*..
gi 966969265 110 E-EAEFY 115
Cdd:cd18370   81 RaEADFY 87

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel regulatory protein (KCNRG); KCNRG, also called potassium channel regulator or protein CLLD4, is an endoplasmic reticulum (ER)-associated tumor suppressor that regulates Kv1 family potassium channel proteins by retaining a fraction of the channels in endomembranes. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265  33 VRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEElQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAE-EGVLEE 111
Cdd:cd18375    3 VTLNVGGKKFTTRPSTLRRFPDSRLARMLDGKD-QDFKVVNGQFFVDRDGSLFSYILDYLRTGQLTLPTEFSDyNRLARE 81

                 ....*....
gi 966969265 112 AEFYNIGPL 120
Cdd:cd18375   82 AEFYGLYSL 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2); This subfamily of KCTD proteins, also called the BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein (BACURD) subfamily, includes KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2). KCTD10 is a BTB/POZ domain-containing protein that interacts with proliferating cell nuclear antigen (PCNA) and polymerase delta, and participates in DNA repair, DNA replication, and cell-cycle control. Its down-regulation could inhibit cell proliferation. KCTD10 also plays crucial roles in embryonic angiogenesis and heart development in mammals by negatively regulating the Notch signaling pathway. KCTD13 is a BTB/POZ domain-containing protein that may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of RhoA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. TNFAIP1, also called protein B12, is a BTB/POZ domain-containing protein that is involved in DNA replication, DNA damage repair, cell apoptosis, and is implicated in human diseases including cancer, Alzheimer's disease (AD) and type 2 diabetic nephropathy. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD10 and KCTD13 BTB domains form a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265  33 VRLNVGGTVFLTTRQTLCReQKSFLSRLCQGE-ELQSDRDetGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAE-EGVLE 110
Cdd:cd18369    1 VKLNVGGSLHYTTIGTLTK-QDTMLRAMFSGRmEVLTDSE--GWILIDRCGKHFGTILNYLRDGSVPLPESRRElAELLA 77

                         90
                 ....*....|.
gi 966969265 111 EAEFYNIGPLI 121
Cdd:cd18369   78 EAKYYLVQGLV 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16); KCTD16 is a BTB/POZ domain-containing protein that is an auxiliary subunit of GABAB receptors associated with mood disorders. It interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265  33 VRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEELQSD---RDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVL 109
Cdd:cd18398    5 VELNVGGQVYFTRHATLVSIPHSLLWKMFSPKRDTANdlaKDSKGRFFIDRDGFLFRYILDYLRDRQVVLPDHFPEKGRL 84

                         90
                 ....*....|....*.
gi 966969265 110 E-EAEFYNIGPLIRII 124
Cdd:cd18398   85 KrEAEYFQLPDLVKLL 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCND/Kv4 subfamily of Shal-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv4, also known as subfamily D, contains three alpha subunit members, Kv4.1 (KCND1), Kv4.2 (KCND2), and Kv4.3 (KCND3), which are orthologs of the Shal gene in Drosophila. They are A-type potassium channels that mediate the native, fast inactivating (A-type) K+ current (IA) described both in the nervous system (A currents) and the heart (transient outward current). Kv4/KCND subfamily alpha subunits form functional homo- or hetero-tetrameric channels through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. They are modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265  33 VRLNVGGTVFLTTRQTLCREQKSFLSRlcQGEELQSDrDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVLEEA 112
Cdd:cd18380    2 IVINVSGRRFETWKNTLEKYPDTLLGS--TEKEFFYD-DDTKEYFFDRDPEIFRHILNFYRTGKLHYPRHECISAYDDEL 78

                 ....*..
gi 966969265 113 EFYNIGP 119
Cdd:cd18380   79 AFFGILP 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 12 (KCTD12); KCTD12, also called predominantly fetal expressed T1 domain (Pfetin), is a BTB/POZ domain-containing protein that is an auxiliary subunit of GABAB receptors associated with mood disorders. It regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. It also regulates colorectal cancer cell stemness through the ERK pathway. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265  33 VRLNVGGTVFLTTRQTLCREQKSFLSRL-CQGEELQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVLE- 110
Cdd:cd18397    5 VELNVGGQVYVTRHTTLVSVPDSLLWHMfSQQKPGELARDSKGRFFLDRDGFLFRYILDYLRDLQLVLPDYFPERSRLQr 84

                         90
                 ....*....|....
gi 966969265 111 EAEFYNIGPLIRII 124
Cdd:cd18397   85 EAEFFQLPELVKRL 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNC/Kv3 subfamily of Shaw-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains four alpha subunit members, Kv3.1 (KCNC1), Kv3.2 (KCNC2), Kv3.3 (KCNC3), and Kv3.4 (KCNC4), which are orthologs of the Shaw gene in Drosophila. Unlike other Kv subfamilies, Kv3 channels typically open only at positive potentials and both, activation and deactivation, in response to changes in voltage are very rapid. They are uniquely associated with the ability of certain neurons to fire action potentials and to release neurotransmitter at high rates of up to 1,000 Hz. Kv3/KCNC subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265  33 VRLNVGGTVFLTTRQTLCREQKSFLSRLCQGEELQSDRD-ETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVLEE 111
Cdd:cd18379    1 IVINVGGVRHETYKSTLRNLPDTRLAWLTETEASAFDYDpVTGEFFFDRHPGVFAQILNYYRTGKLHCPADVCGPLFEEE 80

                 ....*.
gi 966969265 112 AEFYNI 117
Cdd:cd18379   81 LAFWGI 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3); KCND3, also called voltage-gated potassium channel subunit Kv4.3, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. Mutations in KCND3 cause spinocerebellar ataxia. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND3 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265  35 LNVGGTVFLTTRQTLCREQKSFLSRlcqGEELQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVLEEAEF 114
Cdd:cd18419   39 LNVSGRRFQTWRTTLERYPDTLLGS---TEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDEELAF 115

                         90
                 ....*....|..
gi 966969265 115 YNIGPliRIIKD 126
Cdd:cd18419  116 YGILP--EIIGD 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv6, also known as subfamily G, includes KCNG1 (Kv6.1), KCNG2 (Kv6.2 or KCNF2), KCNG3 (Kv6.3) and KCNG4 (Kv6.4), which are regulatory alpha subunits and do not form functional channels on their own. KCNG1 can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit, can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNG3, also called voltage-gated potassium channel subunit Kv10.1, is an electrically silent modulatory subunit that can form functional heterotetrameric channels with KCNB1, and further promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1. KCNG4 is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265  33 VRLNVGGTVFLTTRQTLCREQKSFLSRL--CQGEE----LQSDRDET-GAYLIDRDPTYFGPILNFLRHGKLVLDKDMAE 105
Cdd:cd18382    1 VIINVGGARYSLPWSTLDRFPLTRLSRLkaCRSEDdilrVCDDYDVErNEFFFDRSPEAFGVILLFLRAGKLRLLREMCA 80

                         90
                 ....*....|..
gi 966969265 106 EGVLEEAEFYNI 117
Cdd:cd18382   81 LSFQEELAYWGI 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 1 (KCND1); KCND1, also called voltage-gated potassium channel subunit Kv4.1, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. It may contribute to I (To) current in heart and I (Sa) current in neurons. Its properties are modulated by interactions with other alpha subunits and with regulatory subunits. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265  35 LNVGGTVFLTTRQTLCREQKSFLSRlcQGEELQSDRDeTGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVLEEAEF 114
Cdd:cd18417   39 VNVSGRRFQTWKNTLDRYPDTLLGS--SEKEFFYNED-TQEYFFDRDPEMFRHILNFYRTGRLHYPRHECIQAFDEELSF 115

                 ....*..
gi 966969265 115 YNIGPLI 121
Cdd:cd18417  116 YGIIPEI 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw; Shaw, also called Shaw2, is a voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shaw is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265  33 VRLNVGGTVFLTTRQTLCREQKSFLSRLCqgEELQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVLEEA 112
Cdd:cd18416    4 VVLNVGGIRHETYKATLKKIPATRLSRLT--EALANYDPVLNEYFFDRHPGVFAQILNYYRTGKLHYPTDVCGPLFEEEL 81

                 ....*
gi 966969265 113 EFYNI 117
Cdd:cd18416   82 EFWGL 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3; KCNC1 (also called NGK2, voltage-gated potassium channel subunit Kv3.1, or voltage-gated potassium channel subunit Kv4) and KCNC3 (also called KSHIIID or voltage-gated potassium channel subunit Kv3.3) play important roles in the rapid repolarization of fast-firing brain neurons. Assuming opened or closed conformations in response to the voltage difference across the membrane, the proteins form tetrameric potassium-selective channels through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC1 and KCNC3 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265  35 LNVGGTVFLTTRQTLCREQKSFLSRLCQGEELQS-DRD-ETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAEEGVLEEA 112
Cdd:cd18414    7 INVGGTRHETYRSTLRTLPGTRLAWLAEPDAHSNfDYDpRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEEL 86

                 ....*
gi 966969265 113 EFYNI 117
Cdd:cd18414   87 AFWGI 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 3 (KCNG3); KCNG3, also called voltage-gated potassium channel subunit Kv6.3 or voltage-gated potassium channel subunit Kv10.1, is an electrically silent modulatory subunit that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG3 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265  33 VRLNVGGTVFLTTRQTLCREQKSFLSRL--CQGE----ELQSDRD-ETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAe 105
Cdd:cd18422    1 VTLNVGGTRYSFSREVIKDFPLRRVSRLhgCLSEqdvlEVCDDYDrERNEYFFDRHSEAFGFIMLYVKYGKLRFVPQMC- 79

                         90
                 ....*....|.
gi 966969265 106 egvleEAEFYN 116
Cdd:cd18422   80 -----ELSFYN 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 1 (KCNB1); KCNB1, also called delayed rectifier potassium channel 1 (DRK1) or voltage-gated potassium channel subunit Kv2.1, mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB1 is involved in the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265  33 VRLNVGGTVFLTTRQTLCREQKSFLSRL--CQGE----ELQSDRD-ETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAE 105
Cdd:cd18411   12 VKLNVGGLAHEVLWRTLDRLPRTRLGKLrdCNTHeslmEICDDYNlEENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCA 91

                         90
                 ....*....|..
gi 966969265 106 EGVLEEAEFYNI 117
Cdd:cd18411   92 LSFSQELDYWGI 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNS/Kv9 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv9, also known as subfamily S, includes KCNS1 (Kv9.1), KCNS2 (Kv9.2) and KCNS3 (Kv9.3). They are regulatory alpha subunits that cannot form functional homo-tetrameric channels. Both KCNS1 and KCNS2 are delayed-rectifier K(+) channel alpha subunits that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. KCNS3 is a delayed-rectifier K(+) channel alpha subunit linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265  33 VRLNVGGTVFLTTRQTLCREQKSFLSRL--CQGEE----LQSDRDETG-AYLIDRDPTYFGPILNFLRHGKLVLDKDMAE 105
Cdd:cd18384    1 IRINVGGFRRRLSASALLRFPGTRLGRLlaCHSEEaileLCDDYDVAArEFYFDRNPGFFLYVLHFYRTGKLHVMDELCV 80

                         90
                 ....*....|....*
gi 966969265 106 EGVLEEAEFYNIGPL 120
Cdd:cd18384   81 FSFSQEIEYWGINEF 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shab and similar proteins; Shab is a slow delayed rectifier voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shab is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265  33 VRLNVGGTVFLTTRQTLCREQKSFLSRL--CQGEE----LQSDRD-ETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAE 105
Cdd:cd18413    4 VVINVGGVKHEVLWRTLDRMPHTRLGKLrdSNTHEaiveLCDDYSlADNEYFFDRHPRSFASILNFYRTGKLHLVEEMCV 83

                         90
                 ....*....|....*
gi 966969265 106 EGVLEEAEFYNIGPL 120
Cdd:cd18413   84 LAFSDDLEYWGVDEL 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 2 (KCNB2); KCNB2, also called voltage-gated potassium channel subunit Kv2.2, mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB2 contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966969265  33 VRLNVGGTVFLTTRQTLCREQKSFLSRL--CQGEE--LQSDRD---ETGAYLIDRDPTYFGPILNFLRHGKLVLDKDMAE 105
Cdd:cd18412   19 VKINVGGLNHEVLWRTLDRLPRTRLGKLrdCNTHEslLEVCDDynlNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCA 98

                         90
                 ....*....|..
gi 966969265 106 EGVLEEAEFYNI 117
Cdd:cd18412   99 LSFGQELDYWGI 110