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Conserved domains on  [gi|1622838643|ref|XP_015005513|]
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GAS2-like protein 1 [Macaca mulatta]

Protein Classification

calponin homology domain-containing protein( domain architecture ID 10206868)

calponin homology (CH) domain-containing protein may bind actin filament (F-actin) or serve a regulatory function

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CH_SF super family cl00030
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
 18-152 3.97e-61

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


The actual alignment was detected with superfamily member cd21268:

Pssm-ID: 469584  Cd Length: 142  Bit Score: 200.62  E-value: 3.97e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  18 PFRSSEAYVEAMKEDLAEWLNALYGLGLPGGGDGflTGLATGTTLCQHANAVTEA---------ARALAAARPARGVAFQ 88
Cdd:cd21268     1 PFKSSEEYLYAMKEDLAEWLNTLYNLDITADNFF--EKLETGVLLCKHANNVTRAarefqaqhpERASPLKLPPREVIFY 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622838643  89 AHSVVPGSFMARDNVATFIGWCRTELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLGL 152
Cdd:cd21268    79 RPSAKPGSFQARDNVSNFINWCRQLLGIPEVLLFETDDLVLRKNEKNFVLCLLEVARRGAKFGM 142
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 208-276 1.18e-42

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


:

Pssm-ID: 460480  Cd Length: 69  Bit Score: 148.13  E-value: 1.18e-42
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622838643 208 LDELVREILGRCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRSHVMVRVGGGWDTLEHYLDKHDPCRC 276
Cdd:pfam02187   1 LDDEVRRIVAQCTCPTKFPVEKVGEGKYRFGDSQKLVFVRILRSHVMVRVGGGWDTLEEYLLKHDPCRA 69
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 283-681 3.09e-08

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.26  E-value: 3.09e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  283 PPQPRVRTFSPQRLSPTPSPRPASPVPGSERRGSRPEMTPLSLRSTKEG----------PETPPRPRDQLPPHPRSRRYS 352
Cdd:PHA03247  2554 PLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVddrgdprgpaPPSPLPPDTHAPDPPPPSPSP 2633

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  353 GDSDSSASSAQSGPLGTRSDDTGTGPRRERPSRRLTTGTPASPRRPPalrsqSRDRLDRGRPRGAPGGRGAQLSAPSPAR 432
Cdd:PHA03247  2634 AANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPP-----QRPRRRAARPTVGSLTSLADPPPPPPTP 2708

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  433 RARSQSREEQAVLLVRRDRDGQHSWVPRGRGTGGSGRSTPQTPRARSPAAPRLSRVSSPSPELGTTPASI---FRTPLQL 509
Cdd:PHA03247  2709 EPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGpprRLTRPAV 2788

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  510 DPQQEQQLFRRLEEEFLANARALEAVASVTPTGPAPDPARAPDPPAPDSAYCSSSSSSSSLSVLGGKCGQPGDSGRTANG 589
Cdd:PHA03247  2789 ASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPS 2868

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  590 LPGPRSQALSS----SSDEGSPCPGMGGPLDAPGSSLAGPEPLRTWARGRMDTQPDRKPSRIPTPRGPRRPSGPAELGTW 665
Cdd:PHA03247  2869 RSPAAKPAAPArppvRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD 2948

                          410
                   ....*....|....*.
gi 1622838643  666 HALHSVTPRAEPDSWM 681
Cdd:PHA03247  2949 PAGAGEPSGAVPQPWL 2964
 
Name Accession Description Interval E-value
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
 18-152 3.97e-61

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409117  Cd Length: 142  Bit Score: 200.62  E-value: 3.97e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  18 PFRSSEAYVEAMKEDLAEWLNALYGLGLPGGGDGflTGLATGTTLCQHANAVTEA---------ARALAAARPARGVAFQ 88
Cdd:cd21268     1 PFKSSEEYLYAMKEDLAEWLNTLYNLDITADNFF--EKLETGVLLCKHANNVTRAarefqaqhpERASPLKLPPREVIFY 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622838643  89 AHSVVPGSFMARDNVATFIGWCRTELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLGL 152
Cdd:cd21268    79 RPSAKPGSFQARDNVSNFINWCRQLLGIPEVLLFETDDLVLRKNEKNFVLCLLEVARRGAKFGM 142
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 208-276 1.18e-42

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


Pssm-ID: 460480  Cd Length: 69  Bit Score: 148.13  E-value: 1.18e-42
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622838643 208 LDELVREILGRCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRSHVMVRVGGGWDTLEHYLDKHDPCRC 276
Cdd:pfam02187   1 LDDEVRRIVAQCTCPTKFPVEKVGEGKYRFGDSQKLVFVRILRSHVMVRVGGGWDTLEEYLLKHDPCRA 69
GAS2 smart00243
Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
 206-278 6.12e-40

Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain


Pssm-ID: 128539  Cd Length: 73  Bit Score: 140.66  E-value: 6.12e-40
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622838643  206 RNLDELVREILGRCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRSHVMVRVGGGWDTLEHYLDKHDPCRCSS 278
Cdd:smart00243   1 DKIDDEVKRIVEDCKCPTKFQVEKISEGKYRFGDSQILRLVRILRSTVMVRVGGGWETLDEYLLKHDPCRAKG 73
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 27-149 1.74e-09

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 55.76  E-value: 1.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  27 EAMKEDLAEWLNALYGLGLPGGGDGF-LTGLATGTTLCQHANAVTEAaralaaarpargvAFQAHSVVPGSFMARDNVAT 105
Cdd:pfam00307   1 LELEKELLRWINSHLAEYGPGVRVTNfTTDLRDGLALCALLNKLAPG-------------LVDKKKLNKSEFDKLENINL 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1622838643 106 FIGWCRTELGVPEVLMfETEDLVLRKNeKSVVLCLLEVARRGAR 149
Cdd:pfam00307  68 ALDVAEKKLGVPKVLI-EPEDLVEGDN-KSVLTYLASLFRRFQA 109
PHA03247 PHA03247
large tegument protein UL36; Provisional
 283-681 3.09e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.26  E-value: 3.09e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  283 PPQPRVRTFSPQRLSPTPSPRPASPVPGSERRGSRPEMTPLSLRSTKEG----------PETPPRPRDQLPPHPRSRRYS 352
Cdd:PHA03247  2554 PLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVddrgdprgpaPPSPLPPDTHAPDPPPPSPSP 2633

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  353 GDSDSSASSAQSGPLGTRSDDTGTGPRRERPSRRLTTGTPASPRRPPalrsqSRDRLDRGRPRGAPGGRGAQLSAPSPAR 432
Cdd:PHA03247  2634 AANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPP-----QRPRRRAARPTVGSLTSLADPPPPPPTP 2708

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  433 RARSQSREEQAVLLVRRDRDGQHSWVPRGRGTGGSGRSTPQTPRARSPAAPRLSRVSSPSPELGTTPASI---FRTPLQL 509
Cdd:PHA03247  2709 EPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGpprRLTRPAV 2788

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  510 DPQQEQQLFRRLEEEFLANARALEAVASVTPTGPAPDPARAPDPPAPDSAYCSSSSSSSSLSVLGGKCGQPGDSGRTANG 589
Cdd:PHA03247  2789 ASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPS 2868

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  590 LPGPRSQALSS----SSDEGSPCPGMGGPLDAPGSSLAGPEPLRTWARGRMDTQPDRKPSRIPTPRGPRRPSGPAELGTW 665
Cdd:PHA03247  2869 RSPAAKPAAPArppvRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD 2948

                          410
                   ....*....|....*.
gi 1622838643  666 HALHSVTPRAEPDSWM 681
Cdd:PHA03247  2949 PAGAGEPSGAVPQPWL 2964
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 31-140 2.73e-06

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 46.15  E-value: 2.73e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643   31 EDLAEWLNALYGLGLPGGGDGFLTGLATGTTLCQHANAVTEAARALAAARPArgvafqahsvvPGSFMARDNVATFIGWC 110
Cdd:smart00033   1 KTLLRWVNSLLAEYDKPPVTNFSSDLKDGVALCALLNSLSPGLVDKKKVAAS-----------LSRFKKIENINLALSFA 69

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1622838643  111 RTELGVPEvlMFETEDLVL-RKNEKSVVLCL 140
Cdd:smart00033  70 EKLGGKVV--LFEPEDLVEgPKLILGVIWTL 98
SCP1 COG5199
Calponin [Cytoskeleton];
97-149 4.82e-05

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 44.53  E-value: 4.82e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622838643  97 FMARDNVATFIGWCRtELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGAR 149
Cdd:COG5199    67 FVQMENISSFINGLK-KLRVPEYELFQTNDLFEAKDLRQVVICLYSLSRYAQK 118
 
Name Accession Description Interval E-value
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
 18-152 3.97e-61

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409117  Cd Length: 142  Bit Score: 200.62  E-value: 3.97e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  18 PFRSSEAYVEAMKEDLAEWLNALYGLGLPGGGDGflTGLATGTTLCQHANAVTEA---------ARALAAARPARGVAFQ 88
Cdd:cd21268     1 PFKSSEEYLYAMKEDLAEWLNTLYNLDITADNFF--EKLETGVLLCKHANNVTRAarefqaqhpERASPLKLPPREVIFY 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622838643  89 AHSVVPGSFMARDNVATFIGWCRTELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLGL 152
Cdd:cd21268    79 RPSAKPGSFQARDNVSNFINWCRQLLGIPEVLLFETDDLVLRKNEKNFVLCLLEVARRGAKFGM 142
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 208-276 1.18e-42

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


Pssm-ID: 460480  Cd Length: 69  Bit Score: 148.13  E-value: 1.18e-42
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622838643 208 LDELVREILGRCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRSHVMVRVGGGWDTLEHYLDKHDPCRC 276
Cdd:pfam02187   1 LDDEVRRIVAQCTCPTKFPVEKVGEGKYRFGDSQKLVFVRILRSHVMVRVGGGWDTLEEYLLKHDPCRA 69
CH_GAS2-like cd21204
calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth ...
 23-151 2.64e-41

calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth arrest-specific protein 2 (GAS-2) family includes GAS-2, and GAS-2 like proteins, GAS2L1-3. GAS-2 may play a role in apoptosis by acting as a cell death substrate for caspases. GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2) may be involved in the cross-linking of microtubules and microfilaments. GAS2L3, also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. Members of this family contain a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409053  Cd Length: 131  Bit Score: 146.64  E-value: 2.64e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  23 EAYVEAMKEDLAEWLNALYGLGLPGGGDGflTGLATGTTLCQHANAVTEAARALAAARPARG-----VAFQAHSVVPGSF 97
Cdd:cd21204     1 EEALLPMKEDLAEWLNDLLGDDLTPDNFL--DELRNGVVLCQLAQKIQEAAEKAREAGKKNGpppsyKLKCNENAKPGSF 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622838643  98 MARDNVATFIGWCRtELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLG 151
Cdd:cd21204    79 FARDNVANFLRWCR-KLGVDEVLLFESEDLVLHKNPRQVLLCLLELARIAARYG 131
GAS2 smart00243
Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
 206-278 6.12e-40

Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain


Pssm-ID: 128539  Cd Length: 73  Bit Score: 140.66  E-value: 6.12e-40
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622838643  206 RNLDELVREILGRCTCPDQFPMIKVSEGKYRVGDSSLLIFVRVLRSHVMVRVGGGWDTLEHYLDKHDPCRCSS 278
Cdd:smart00243   1 DKIDDEVKRIVEDCKCPTKFQVEKISEGKYRFGDSQILRLVRILRSTVMVRVGGGWETLDEYLLKHDPCRAKG 73
CH_GAS2 cd21267
calponin homology (CH) domain found in growth arrest-specific protein 2; Growth ...
 23-152 1.36e-18

calponin homology (CH) domain found in growth arrest-specific protein 2; Growth arrest-specific protein 2 (GAS-2) may play a role in apoptosis by acting as a cell death substrate for caspases. It contains a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409116  Cd Length: 136  Bit Score: 82.68  E-value: 1.36e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  23 EAYVEAMKEDLAEWLNALYGLGLPGGGDGFLtgLATGTTLCQHANAVTEAARALAAARPARGVAFQAHSV-----VP-GS 96
Cdd:cd21267     2 EASLLPMKEDLALWLTNLLGKEITAESFMEK--LDNGALLCQLAETLQEKFKENSADANKPGKSLPVRKIpcranAPsGS 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622838643  97 FMARDNVATFIGWCRtELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLGL 152
Cdd:cd21267    80 FFARDNTANFLSWCR-DVGVGDTCLFESEGLVLHKQPREVCLCLLELGRIAARFGV 134
CH_GAS2L3 cd21269
calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth ...
 23-151 5.97e-16

calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth arrest-specific protein 2-like 3 (GAS2L3), also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. It contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409118  Cd Length: 130  Bit Score: 74.87  E-value: 5.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  23 EAYVEAMKEDLAEWLNALYGLGLPGGGDGFLtgLATGTTLCQHANAVTEAARALAAARPARGVAFQA----HSVVPGSFM 98
Cdd:cd21269     1 EATLVPMQEDLSIWLSGMLGKEVKAERFMEE--LDNGVLLCQLIGVLQSKIKECCSTEELKHFPMRKvpckKDAPSGSFF 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622838643  99 ARDNVATFIGWCRtELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGARLG 151
Cdd:cd21269    79 ARDNTANFLSWCR-AIGVDETYLFESEGLVLHKDPRQVCLCLLEIGRIVSRYG 130
CH_SF cd00014
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
 30-145 5.89e-11

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


Pssm-ID: 409031 [Multi-domain]  Cd Length: 103  Bit Score: 59.66  E-value: 5.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  30 KEDLAEWLNALYGLGLPGGGDGFLTGLATGTTLCQHANAVTEAARALAaarpargvafqaHSVVPGSFMARDNVATFIGW 109
Cdd:cd00014     1 EEELLKWINEVLGEELPVSITDLFESLRDGVLLCKLINKLSPGSIPKI------------NKKPKSPFKKRENINLFLNA 68

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1622838643 110 CRtELGVPEVLMFETEDLVLRKNEKSVVLCLLEVAR 145
Cdd:cd00014    69 CK-KLGLPELDLFEPEDLYEKGNLKKVLGTLWALAL 103
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 27-149 1.74e-09

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 55.76  E-value: 1.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  27 EAMKEDLAEWLNALYGLGLPGGGDGF-LTGLATGTTLCQHANAVTEAaralaaarpargvAFQAHSVVPGSFMARDNVAT 105
Cdd:pfam00307   1 LELEKELLRWINSHLAEYGPGVRVTNfTTDLRDGLALCALLNKLAPG-------------LVDKKKLNKSEFDKLENINL 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1622838643 106 FIGWCRTELGVPEVLMfETEDLVLRKNeKSVVLCLLEVARRGAR 149
Cdd:pfam00307  68 ALDVAEKKLGVPKVLI-EPEDLVEGDN-KSVLTYLASLFRRFQA 109
PHA03247 PHA03247
large tegument protein UL36; Provisional
 283-681 3.09e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.26  E-value: 3.09e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  283 PPQPRVRTFSPQRLSPTPSPRPASPVPGSERRGSRPEMTPLSLRSTKEG----------PETPPRPRDQLPPHPRSRRYS 352
Cdd:PHA03247  2554 PLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVddrgdprgpaPPSPLPPDTHAPDPPPPSPSP 2633

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  353 GDSDSSASSAQSGPLGTRSDDTGTGPRRERPSRRLTTGTPASPRRPPalrsqSRDRLDRGRPRGAPGGRGAQLSAPSPAR 432
Cdd:PHA03247  2634 AANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPP-----QRPRRRAARPTVGSLTSLADPPPPPPTP 2708

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  433 RARSQSREEQAVLLVRRDRDGQHSWVPRGRGTGGSGRSTPQTPRARSPAAPRLSRVSSPSPELGTTPASI---FRTPLQL 509
Cdd:PHA03247  2709 EPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGpprRLTRPAV 2788

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  510 DPQQEQQLFRRLEEEFLANARALEAVASVTPTGPAPDPARAPDPPAPDSAYCSSSSSSSSLSVLGGKCGQPGDSGRTANG 589
Cdd:PHA03247  2789 ASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPS 2868

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  590 LPGPRSQALSS----SSDEGSPCPGMGGPLDAPGSSLAGPEPLRTWARGRMDTQPDRKPSRIPTPRGPRRPSGPAELGTW 665
Cdd:PHA03247  2869 RSPAAKPAAPArppvRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD 2948

                          410
                   ....*....|....*.
gi 1622838643  666 HALHSVTPRAEPDSWM 681
Cdd:PHA03247  2949 PAGAGEPSGAVPQPWL 2964
CH_SCP1-like cd21210
calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar ...
 56-145 2.17e-06

calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar proteins; The family includes transgelins from Saccharomyces cerevisiae and Schizosaccharomyces pombe, which are also called SCP1 and STG1, respectively. Transgelin, also called calponin homolog 1, has actin-binding and actin-bundling activity. It stabilizes actin filaments against disassembly. Transgelin contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409059 [Multi-domain]  Cd Length: 101  Bit Score: 46.59  E-value: 2.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  56 LATGTTLCQHANAVTEAAralaaarparGVAFQAhsvVPGSFMARDNVATFIGWCRtELGVPEVLMFETEDLVLRKNEKS 135
Cdd:cd21210    26 LKDGVVLCKLANRILPAD----------IRKYKE---SKMPFVQMENISAFLNAAR-KLGVPENDLFQTVDLFERKNPAQ 91

                          90
                  ....*....|
gi 1622838643 136 VVLCLLEVAR 145
Cdd:cd21210    92 VLQCLHALSR 101
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 31-140 2.73e-06

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 46.15  E-value: 2.73e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643   31 EDLAEWLNALYGLGLPGGGDGFLTGLATGTTLCQHANAVTEAARALAAARPArgvafqahsvvPGSFMARDNVATFIGWC 110
Cdd:smart00033   1 KTLLRWVNSLLAEYDKPPVTNFSSDLKDGVALCALLNSLSPGLVDKKKVAAS-----------LSRFKKIENINLALSFA 69

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1622838643  111 RTELGVPEvlMFETEDLVL-RKNEKSVVLCL 140
Cdd:smart00033  70 EKLGGKVV--LFEPEDLVEgPKLILGVIWTL 98
CH_IQGAP cd21206
calponin homology (CH) domain found in the IQ motif containing GTPase activating protein ...
 96-140 2.16e-05

calponin homology (CH) domain found in the IQ motif containing GTPase activating protein family; Members of the IQ motif containing GTPase activating protein (IQGAP) family are associated with the Ras GTP-binding protein and act as essential regulators of cytoskeletal function. There are three known IQGAP family members: IQGAP1, IQGAP2, and IQGAP3. They are multi-domain molecules having a calponin-homology (CH) domain which binds F-actin, IQGAP-specific repeats, a single WW domain, four IQ motifs that mediate interactions with calmodulin, and a RasGAP related domain that binds active Rho family GTPases. IQGAP1 negatively regulates Ras family GTPases by stimulating their intrinsic GTPase activity. It lacks GAP activity. Both IQGAP1 and IQGAP2 specifically bind to Cdc42 and Rac1, but not to RhoA. Despite similarities to part of the sequence of RasGAP, neither IQGAP1 nor IQGAP2 interacts with Ras. IQGAP3 regulates the organization of the cytoskeleton under the regulation of Rac1 and Cdc42 in neuronal cells. The depletion of IQGAP3 is shown to impair neurite or axon outgrowth in neuronal cells with disorganized cytoskeleton.


Pssm-ID: 409055 [Multi-domain]  Cd Length: 118  Bit Score: 44.14  E-value: 2.16e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1622838643  96 SFMARDNVATFIGWCRtELGVPEVLMFETEDLVLRKNEKSVVLCL 140
Cdd:cd21206    64 QFRHTDNINHFLRALK-KIGLPKIFHFETTDLYEKKNIPKVIYCL 107
PHA03247 PHA03247
large tegument protein UL36; Provisional
 277-512 3.70e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 3.70e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  277 SSTAHRPPQPRVRTFSPQRLSPTPSPRPASPVPGSERRGSRPEMTPLSLRSTKEGPETPPRPRDQLPPHPRSRRYSGDSD 356
Cdd:PHA03247  2763 TAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPP 2842

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  357 SSASSAQSGPLGTRSDDtgtGPRRERPSRRLTTGTPASPRRPPAlRSQSRDRLDRG-RPRGAPGGRGAQLSAPSPARRAR 435
Cdd:PHA03247  2843 PGPPPPSLPLGGSVAPG---GDVRRRPPSRSPAAKPAAPARPPV-RRLARPAVSRStESFALPPDQPERPPQPQAPPPPQ 2918

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622838643  436 SQSREEQAVLlvrrdrdgqhswvPRGRGTGGSGRSTPQTPRARSPAAPRLSRVsSPSPELGTTPASIFRTPLQLDPQ 512
Cdd:PHA03247  2919 PQPQPPPPPQ-------------PQPPPPPPPRPQPPLAPTTDPAGAGEPSGA-VPQPWLGALVPGRVAVPRFRVPQ 2981
SCP1 COG5199
Calponin [Cytoskeleton];
97-149 4.82e-05

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 44.53  E-value: 4.82e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622838643  97 FMARDNVATFIGWCRtELGVPEVLMFETEDLVLRKNEKSVVLCLLEVARRGAR 149
Cdd:COG5199    67 FVQMENISSFINGLK-KLRVPEYELFQTNDLFEAKDLRQVVICLYSLSRYAQK 118
CH_dMP20-like cd21207
calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 ...
 95-145 5.23e-04

calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 (dMP20) and similar domains; This subfamily contains Drosophila melanogaster muscle-specific protein 20 (dMP20), Echinococcus granulosus myophilin, Dictyostelium discoideum Rac guanine nucleotide exchange factor B (also called Trix), and similar proteins. dMP20 is present only in the synchronous muscles of D. melanogaster. It may be involved in the system linking the nerve impulse with the contraction or the relaxation process. Trix is involved in the regulation of the late steps of the endocytic pathway. dMP20 contains a single copy of the CH domain, while Trix (triple CH-domain array exchange factor) contains three, two type 3 CH domains which are included in this model, and one type 1 CH domain that is not included in this subfamily, but is part of the superfamily. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409056 [Multi-domain]  Cd Length: 107  Bit Score: 39.99  E-value: 5.23e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622838643  95 GSFMARDNVATFIGWCRtELGVPEVLMFETEDLVLRKNEKSVVLCLLEVAR 145
Cdd:cd21207    58 MAFKLMENIENFLTACK-GYGVPKTDLFQTVDLYEKKNIPQVTNCLFALGR 107
PHA03247 PHA03247
large tegument protein UL36; Provisional
 282-494 8.90e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 8.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  282 RPPQPRVRTFSPQRLSPTPSPRPASPVPGSERRGSRPEMTPLSLRSTKEGPETPPRPRDQ-------LPPHPRSRRYSGD 354
Cdd:PHA03247  2654 DDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHalvsatpLPPGPAAARQASP 2733

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  355 SDSSASSAQSGPLGTRSDdtGTGPRRERPSRRLTTGTPASPRRPPAlrsqsrdrldrGRPRGAPGGRGAQLSAPSPARRA 434
Cdd:PHA03247  2734 ALPAAPAPPAVPAGPATP--GGPARPARPPTTAGPPAPAPPAAPAA-----------GPPRRLTRPAVASLSESRESLPS 2800

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  435 RSQSREEQAVLLVRrdrdgqhswVPRGRGTGGSGRSTPqTPRARSPAAPRLSRVSSPSPE 494
Cdd:PHA03247  2801 PWDPADPPAAVLAP---------AAALPPAASPAGPLP-PPTSAQPTAPPPPPGPPPPSL 2850
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 272-503 1.68e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.70  E-value: 1.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  272 DPCRCSSTAHRPPQPRVRTFSPQRLSPTPSPRPASPVPGSERRGSRPEMTPLSLRST--KEGPETPPRPRDQLPPHPRSR 349
Cdd:PHA03307    81 ANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMlrPVGSPGPPPAASPPAAGASPA 160

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  350 RYSGDSDSSASSAQSGPLGTRSDDTGTGPRRERPSRRLTTGTPASPRRPPALRSQSRDRLDRGRPRGAPGGRGAQLSAPS 429
Cdd:PHA03307   161 AVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSS 240

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622838643  430 PARRARSQSREEQAVLLVRRDRDGQHSWvPRGRGTGGSGRSTPQTPRARSPAAPRLSRVSSPSPELGTTPASIF 503
Cdd:PHA03307   241 SSESSGCGWGPENECPLPRPAPITLPTR-IWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPR 313
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 278-443 2.47e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.31  E-value: 2.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  278 STAHRPPQPRVRTFSPQRLSPTPSPRPASPVPGSERrGSRPEMTPLSLRSTKEGPETPPRPRdQLPPHPRSRRYSGDSDS 357
Cdd:PHA03307   253 NECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSS-SSPRERSPSPSPSSPGSGPAPSSPR-ASSSSSSSRESSSSSTS 330

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  358 SASSAQSGPLGTRSDDTGTGPRRERPSRRLTTGTPAS---PRRPPALRSQSRDRLDRGRPRGAPGGRGAQLSAPSPARRA 434
Cdd:PHA03307   331 SSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKrprPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAG 410


                   ....*....
gi 1622838643  435 RSQSREEQA 443
Cdd:PHA03307   411 RPRPSPLDA 419
PHA03247 PHA03247
large tegument protein UL36; Provisional
 275-406 2.63e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 2.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  275 RCSSTAHRPPQPRVRTFSPQRLSPTPSPRPASPVPgserrgSRPEMTPLSLRSTKEGPETPPRPRDQLPPHPRSrrysGD 354
Cdd:PHA03247  2882 PVRRLARPAVSRSTESFALPPDQPERPPQPQAPPP------PQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDP----AG 2951

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1622838643  355 SDSSASSAQSGPLGTRSDDTGTGPRRERPSRRLTTGTPASPRRPPALRSQSR 406
Cdd:PHA03247  2952 AGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSR 3003
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 262-660 4.51e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 4.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  262 DTLEHYLDKHDPCRCSSTAHRPPQPRVRTFSPQRLSPTPSPRPASPVPGSERRGSRPEMTplslrstkEGPETPPRPRDQ 341
Cdd:PHA03307     9 DLIEAAAEGGEFFPRPPATPGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPP--------TGPPPGPGTEAP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  342 lPPHPRSRRYSGDSDSSASSAQSGPLGTRSDDTGTGPRRERPSRRLTTGTPASPRRPPALRSQSRDRLDRGRPRGAPGGR 421
Cdd:PHA03307    81 -ANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASP 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  422 GAQLSAPSPARrarsqsreeQAVLLVRRDRDGQHSWVPRGRGTGGSGRSTPQTPRARSPAAPRLSRVSSPSPELGTTPAS 501
Cdd:PHA03307   160 AAVASDAASSR---------QAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAAD 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  502 ifrtplqlDPQQEQQLFRRLEEEFLANARALEAVASVTPTGPAPDPARAPDPPAPDSAYCSSSSSSSSLSVLGGKCGQPG 581
Cdd:PHA03307   231 --------DAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSS 302

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  582 DSGRTANGlPGPRSQALSSSSDEGSPCPGMGGPLDAPGSSLAGPEPLR--TWARGRMDTQPDRKPSRIPTPRGPRRPSGP 659
Cdd:PHA03307   303 PGSGPAPS-SPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRspSPSRPPPPADPSSPRKRPRPSRAPSSPAAS 381


                   .
gi 1622838643  660 A 660
Cdd:PHA03307   382 A 382
PHA03379 PHA03379
EBNA-3A; Provisional
 244-540 4.52e-03

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 40.43  E-value: 4.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643 244 IFVRVLRSHVMVRVGGGWDTLEHYLDKhdPCRCSSTAHRPPQPRVRTFSPQRLSPTPSPRPA-SPVPGSERRGS------ 316
Cdd:PHA03379  381 IFLRRLHRLLLMRAGKLTERAREALEK--ASEPTYGTPRPPVEKPRPEVPQSLETATSHGSAqVPEPPPVHDLEpgplhd 458

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643 317 RPEMTPLSLRSTKEGPETPPRPRDQLPPHPRSRRYSGDSDSSAssaqsgplgtrsddTGTGPRRERPSRRLTTGTPASPR 396
Cdd:PHA03379  459 QHSMAPCPVAQLPPGPLQDLEPGDQLPGVVQDGRPACAPVPAP--------------AGPIVRPWEASLSQVPGVAFAPV 524

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643 397 RPPALrsqsrdrldRGRPRGAPGGRGAQLSAPSPARRARSQSREEQAVLLVrRDRDGQHSWVPRGRGTGGSGRSTPQTPR 476
Cdd:PHA03379  525 MPQPM---------PVEPVPVPTVALERPVCPAPPLIAMQGPGETSGIVRV-RERWRPAPWTPNPPRSPSQMSVRDRLAR 594

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622838643 477 ARSPAAPRLSRVSSPSPELGTTPAsifRTPLQLDPQQEQQLFRRLEEEFLANARALEAVASVTP 540
Cdd:PHA03379  595 LRAEAQPYQASVEVQPPQLTQVSP---QQPMEYPLEPEQQMFPGSPFSQVADVMRAGGVPAMQP 655
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 256-417 8.61e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 39.38  E-value: 8.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  256 RVGGGWDTLEHYLDKHDPCRcSSTAHRPPQPRVRTFSPQRLSPTPSPRPASPVPGSERRGSRPEMTPLSLRSTKEGPETP 335
Cdd:PHA03307   763 LVPAKLAEALALLEPAEPQR-GAGSSPPVRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGSESSGPARPPGA 841

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838643  336 ---PRPRDQLPPHPRSRRYSGDSDSSASSAQSGPLGTRSDDTGTGPRRERPSRRLTTGTPASPRRPPALRSQSRDRLDRG 412
Cdd:PHA03307   842 aarPPPARSSESSKSKPAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRPAPRVKLGPMPPGGP 921


                   ....*
gi 1622838643  413 RPRGA 417
Cdd:PHA03307   922 DPRGG 926
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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