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Conserved domains on  [gi|966966049|ref|XP_015004283|]
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brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X2 [Macaca mulatta]

Protein Classification

ARF family guanine-nucleotide exchange factor( domain architecture ID 1001583)

ARF family guanine-nucleotide exchange factor activates ARF proteins by exchanging bound GDP for free GTP

Gene Ontology:  GO:0032012|GO:0015031
PubMed:  11752622

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03076 super family cl33628
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 11-1710 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


The actual alignment was detected with superfamily member PLN03076:

Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1061.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049   11 VSRALEKILadKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKA------------------NFIEADKYFLPF 72
Cdd:PLN03076   14 VSPALEKII--KNASWRKHSKLAHECKAVIERLNSPEKNPPSTSSAAADSasasslpgplhdggsieySLAESELILSPL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049   73 ELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETICNCFQgpQTDEGVQLQIIKALLTAVTSPHI 152
Cdd:PLN03076   92 INACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHD--LGDEGIELLVLKTLLSAVTSTSL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  153 EIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMEnqvlqeARELEKPIQskpqsPVIQAAAVSPkfvr 232
Cdd:PLN03076  170 RIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRME------ADSSTVPIQ-----PIVVAELMEP---- 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  233 lkhsqaqskpttPEKTDlTNGEHARSDSGKVST-----ENGHAPRERGSSL-SGTDDGAQEVVKDILEDVVTSAIKAAEK 306
Cdd:PLN03076  235 ------------AEKSD-SDTSMTQFVQGFITKimqdiDGVLNPATAGKSSgSGAHDGAFETTATVETTNPADLLDSTDK 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  307 HGLtepERVLGELECQECAIPPGVDENSQTNGIADDrqslssadnlESDAQghqvaarFSHVLQKDAFLVFRSLCKLSMK 386
Cdd:PLN03076  302 DML---DAKYWEISMYKSALEGRKGELADGEVEKDD----------DLEVQ-------IGNKLRRDAFLVFRALCKLSMK 361

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  387 -PLGEGPPDPKSheLRSKVVSLQLLLSVLQNAGPVFRTHEMFINAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNF 465
Cdd:PLN03076  362 tPPKEALADPQL--MRGKILALELLKILLENAGAVFRTSDRFLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRF 439

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  466 KMHLKMQIEVFFKEIFLNILET-STSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQG-R 543
Cdd:PLN03076  440 RAGLKAEIGVFFPMIVLRVLENvAQPNFQQKMIVLRFLDKLCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGvP 519

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  544 SGHELGMTPLQELSLRKKGLECLVSILKCMVEW-SKDLYVNPNHQTslgqERLMDQEMGDGKG-LDMARRCSVTSMESTV 621
Cdd:PLN03076  520 PGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWmNKQLRLPDPASL----KKLDAVENNLEPGsLPVANGNGDENGEGSD 595

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  622 SSGTQTTIQDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSTR 701
Cdd:PLN03076  596 SHSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEFLINANKVGESPEEIAAFLKDASGLNKTLIGDYLGERED 675

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  702 FNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNqgQTLFASADTAYVLAYSIIMLTTD 781
Cdd:PLN03076  676 LSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFAERYCKCN--PKAFSSADTAYVLAYSVIMLNTD 753

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  782 LHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKE-----TKE--------------LTIATKSTK 842
Cdd:PLN03076  754 AHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNEIKMKEddlvpQQKqsansnrilgldsiLNIVIRKRG 833

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  843 QNVASEKQRRLLYNLEMEQMAKTAKAlmEAVshakapFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDDTEVASLCLE 922
Cdd:PLN03076  834 EDSYMETSDDLIKHMQEQFKEKARKS--ESV------YYAATDVVILRFMVEVCWAPMLAAFSVPLDQSDDEVVTFQCLE 905

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  923 GIRCAIRIACIFGMQLERDAYVQALARFSLLTASSSItemKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQ 1002
Cdd:PLN03076  906 GFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI---KQKNIDAIKAIVSIADEDGNYLQEAWEHILTCVSRFEHLH 982

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049 1003 LIGTG--------------------VKTRYLSGSGREREGSLKGHTLAGEE--FMGLGLGNLVSGGVDKRQMAS------ 1054
Cdd:PLN03076  983 LLGEGappdatffaapqnesdkskqAKSPILPVLKRKGPGKLQYAAAAVRRgsYDSAGVGGKASGVVTSEQMNNlvsnln 1062

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049 1055 FQESVGETSsqsvvvaVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIW 1134
Cdd:PLN03076 1063 MLEQVGSFE-------MNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIVEIAHYNMNRIRLVWSSIW 1135

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049 1135 HVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMVIRCIAQMVNSQA 1214
Cdd:PLN03076 1136 HVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVEIRELIIRCVSQMVLSRV 1215

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049 1215 ANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCHIVTTIFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIR 1294
Cdd:PLN03076 1216 NNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAFTNSRFNKDISLNAIAFLR 1295

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049 1295 FCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRG----------------WFPILFELSCIINRCKLDVRTRGLTVMFEIM 1358
Cdd:PLN03076 1296 FCATKLAEGDLGSSSRNKDKEAPPSSPQSGKDGkqesgeftdkddhlyfWFPLLAGLSELSFDPRPEIRKSALQVLFDTL 1375

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049 1359 KSYGHTFEKHWWQDLFRIV-FRIFDNMK---------LPEQQSEKSE--------WMTTTCNHALYAICDVFTQFYEALN 1420
Cdd:PLN03076 1376 RNHGHLFSLPLWERVFESVlFPIFDYVRhaidpsggdEPEGQGVDGDqgeldqdaWLYETCTLALQLVVDLFVKFYPTVN 1455

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049 1421 EvLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPEVWDETCNCMLDIFKTTIPHVLLTWRPVGMEEDSSEk 1500
Cdd:PLN03076 1456 P-LLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANATLPDFSYVVSGEYMPAENIQ- 1533

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049 1501 hlDVDLDRQSLSSIDKNPSERGQSqlsnptddswkgrpyanQKLFASLL-IKC--VVQLELIQTIdnivfypatskkeda 1577
Cdd:PLN03076 1534 --DSENAEAASSSTADNDAEAERS-----------------RRLYAAISdAKCraAVQLLLIQAV--------------- 1579

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049 1578 ehmvaaqqdtldadihieTEDQGMYK-YMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSK-PNLLKQET 1655
Cdd:PLN03076 1580 ------------------MEIYNMYRpRLSAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQdPPLLRLEN 1641

                        1770      1780      1790      1800      1810
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 966966049 1656 SSLACCLRILFRMYVDENRRDSWEEIQQRLLTVCSEALAYFItvnsESHREAWTS 1710
Cdd:PLN03076 1642 ESYQICLTFLQNLILDKPPLAKEAEVESRLVELCEEVLQFYI----ETSTAGQDS 1692
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 11-1710 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1061.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049   11 VSRALEKILadKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKA------------------NFIEADKYFLPF 72
Cdd:PLN03076   14 VSPALEKII--KNASWRKHSKLAHECKAVIERLNSPEKNPPSTSSAAADSasasslpgplhdggsieySLAESELILSPL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049   73 ELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETICNCFQgpQTDEGVQLQIIKALLTAVTSPHI 152
Cdd:PLN03076   92 INACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHD--LGDEGIELLVLKTLLSAVTSTSL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  153 EIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMEnqvlqeARELEKPIQskpqsPVIQAAAVSPkfvr 232
Cdd:PLN03076  170 RIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRME------ADSSTVPIQ-----PIVVAELMEP---- 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  233 lkhsqaqskpttPEKTDlTNGEHARSDSGKVST-----ENGHAPRERGSSL-SGTDDGAQEVVKDILEDVVTSAIKAAEK 306
Cdd:PLN03076  235 ------------AEKSD-SDTSMTQFVQGFITKimqdiDGVLNPATAGKSSgSGAHDGAFETTATVETTNPADLLDSTDK 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  307 HGLtepERVLGELECQECAIPPGVDENSQTNGIADDrqslssadnlESDAQghqvaarFSHVLQKDAFLVFRSLCKLSMK 386
Cdd:PLN03076  302 DML---DAKYWEISMYKSALEGRKGELADGEVEKDD----------DLEVQ-------IGNKLRRDAFLVFRALCKLSMK 361

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  387 -PLGEGPPDPKSheLRSKVVSLQLLLSVLQNAGPVFRTHEMFINAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNF 465
Cdd:PLN03076  362 tPPKEALADPQL--MRGKILALELLKILLENAGAVFRTSDRFLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRF 439

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  466 KMHLKMQIEVFFKEIFLNILET-STSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQG-R 543
Cdd:PLN03076  440 RAGLKAEIGVFFPMIVLRVLENvAQPNFQQKMIVLRFLDKLCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGvP 519

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  544 SGHELGMTPLQELSLRKKGLECLVSILKCMVEW-SKDLYVNPNHQTslgqERLMDQEMGDGKG-LDMARRCSVTSMESTV 621
Cdd:PLN03076  520 PGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWmNKQLRLPDPASL----KKLDAVENNLEPGsLPVANGNGDENGEGSD 595

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  622 SSGTQTTIQDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSTR 701
Cdd:PLN03076  596 SHSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEFLINANKVGESPEEIAAFLKDASGLNKTLIGDYLGERED 675

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  702 FNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNqgQTLFASADTAYVLAYSIIMLTTD 781
Cdd:PLN03076  676 LSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFAERYCKCN--PKAFSSADTAYVLAYSVIMLNTD 753

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  782 LHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKE-----TKE--------------LTIATKSTK 842
Cdd:PLN03076  754 AHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNEIKMKEddlvpQQKqsansnrilgldsiLNIVIRKRG 833

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  843 QNVASEKQRRLLYNLEMEQMAKTAKAlmEAVshakapFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDDTEVASLCLE 922
Cdd:PLN03076  834 EDSYMETSDDLIKHMQEQFKEKARKS--ESV------YYAATDVVILRFMVEVCWAPMLAAFSVPLDQSDDEVVTFQCLE 905

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  923 GIRCAIRIACIFGMQLERDAYVQALARFSLLTASSSItemKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQ 1002
Cdd:PLN03076  906 GFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI---KQKNIDAIKAIVSIADEDGNYLQEAWEHILTCVSRFEHLH 982

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049 1003 LIGTG--------------------VKTRYLSGSGREREGSLKGHTLAGEE--FMGLGLGNLVSGGVDKRQMAS------ 1054
Cdd:PLN03076  983 LLGEGappdatffaapqnesdkskqAKSPILPVLKRKGPGKLQYAAAAVRRgsYDSAGVGGKASGVVTSEQMNNlvsnln 1062

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049 1055 FQESVGETSsqsvvvaVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIW 1134
Cdd:PLN03076 1063 MLEQVGSFE-------MNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIVEIAHYNMNRIRLVWSSIW 1135

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049 1135 HVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMVIRCIAQMVNSQA 1214
Cdd:PLN03076 1136 HVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVEIRELIIRCVSQMVLSRV 1215

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049 1215 ANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCHIVTTIFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIR 1294
Cdd:PLN03076 1216 NNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAFTNSRFNKDISLNAIAFLR 1295

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049 1295 FCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRG----------------WFPILFELSCIINRCKLDVRTRGLTVMFEIM 1358
Cdd:PLN03076 1296 FCATKLAEGDLGSSSRNKDKEAPPSSPQSGKDGkqesgeftdkddhlyfWFPLLAGLSELSFDPRPEIRKSALQVLFDTL 1375

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049 1359 KSYGHTFEKHWWQDLFRIV-FRIFDNMK---------LPEQQSEKSE--------WMTTTCNHALYAICDVFTQFYEALN 1420
Cdd:PLN03076 1376 RNHGHLFSLPLWERVFESVlFPIFDYVRhaidpsggdEPEGQGVDGDqgeldqdaWLYETCTLALQLVVDLFVKFYPTVN 1455

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049 1421 EvLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPEVWDETCNCMLDIFKTTIPHVLLTWRPVGMEEDSSEk 1500
Cdd:PLN03076 1456 P-LLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANATLPDFSYVVSGEYMPAENIQ- 1533

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049 1501 hlDVDLDRQSLSSIDKNPSERGQSqlsnptddswkgrpyanQKLFASLL-IKC--VVQLELIQTIdnivfypatskkeda 1577
Cdd:PLN03076 1534 --DSENAEAASSSTADNDAEAERS-----------------RRLYAAISdAKCraAVQLLLIQAV--------------- 1579

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049 1578 ehmvaaqqdtldadihieTEDQGMYK-YMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSK-PNLLKQET 1655
Cdd:PLN03076 1580 ------------------MEIYNMYRpRLSAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQdPPLLRLEN 1641

                        1770      1780      1790      1800      1810
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 966966049 1656 SSLACCLRILFRMYVDENRRDSWEEIQQRLLTVCSEALAYFItvnsESHREAWTS 1710
Cdd:PLN03076 1642 ESYQICLTFLQNLILDKPPLAKEAEVESRLVELCEEVLQFYI----ETSTAGQDS 1692
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 642-826 6.50e-96

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 307.08  E-value: 6.50e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049   642 QKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSTRFNKEVMYAYVDQLDFCEKEF 721
Cdd:pfam01369    1 RKKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049   722 VSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGqtLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNR 801
Cdd:pfam01369   81 DEALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPG--VFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLR 158

                          170       180
                   ....*....|....*....|....*
gi 966966049   802 GINDSKDLPEEYLSSIYEEIEGKKI 826
Cdd:pfam01369  159 GINDGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 642-826 2.95e-85

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 276.41  E-value: 2.95e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  642 QKEIIEHGIELFNKKPKRGIQFLQEQGML-GTSVEDIAQFLHQEERLDSTQVGDFLGDSTRFNKEVMYAYVDQLDFCEKE 720
Cdd:cd00171     1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  721 FVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGqTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMN 800
Cdd:cd00171    81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPG-IFSSSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNL 159

                         170       180
                  ....*....|....*....|....*.
gi 966966049  801 RGINDSKDLPEEYLSSIYEEIEGKKI 826
Cdd:cd00171   160 RGINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 640-826 3.47e-80

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 262.23  E-value: 3.47e-80
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049    640 KQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGT-SVEDIAQFLHQEERLDSTQVGDFLGDSTRFNKEVMYAYVDQLDFCE 718
Cdd:smart00222    2 KGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLANeDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFSA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049    719 KEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIK 798
Cdd:smart00222   82 KDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSKANADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFIK 161

                           170       180
                    ....*....|....*....|....*...
gi 966966049    799 MNRGINDSKDLPEEYLSSIYEEIEGKKI 826
Cdd:smart00222  162 NVRGSNDGEDLPREFLEELYDSIKNNEI 189
 
Name Accession Description Interval E-value
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 11-1710 0e+00

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 1061.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049   11 VSRALEKILadKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKA------------------NFIEADKYFLPF 72
Cdd:PLN03076   14 VSPALEKII--KNASWRKHSKLAHECKAVIERLNSPEKNPPSTSSAAADSasasslpgplhdggsieySLAESELILSPL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049   73 ELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETICNCFQgpQTDEGVQLQIIKALLTAVTSPHI 152
Cdd:PLN03076   92 INACGTGSAKIVDPALDCIQKLIAHGYLRGEADPSGGPEALLLAKLIESVCKCHD--LGDEGIELLVLKTLLSAVTSTSL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  153 EIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMEnqvlqeARELEKPIQskpqsPVIQAAAVSPkfvr 232
Cdd:PLN03076  170 RIHGDCLLQAVRTCYDIYLGSKNVVNQTTAKASLIQMLVIVFRRME------ADSSTVPIQ-----PIVVAELMEP---- 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  233 lkhsqaqskpttPEKTDlTNGEHARSDSGKVST-----ENGHAPRERGSSL-SGTDDGAQEVVKDILEDVVTSAIKAAEK 306
Cdd:PLN03076  235 ------------AEKSD-SDTSMTQFVQGFITKimqdiDGVLNPATAGKSSgSGAHDGAFETTATVETTNPADLLDSTDK 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  307 HGLtepERVLGELECQECAIPPGVDENSQTNGIADDrqslssadnlESDAQghqvaarFSHVLQKDAFLVFRSLCKLSMK 386
Cdd:PLN03076  302 DML---DAKYWEISMYKSALEGRKGELADGEVEKDD----------DLEVQ-------IGNKLRRDAFLVFRALCKLSMK 361

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  387 -PLGEGPPDPKSheLRSKVVSLQLLLSVLQNAGPVFRTHEMFINAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNF 465
Cdd:PLN03076  362 tPPKEALADPQL--MRGKILALELLKILLENAGAVFRTSDRFLGAIKQYLCLSLLKNSASSLMIIFQLSCSIFISLVSRF 439

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  466 KMHLKMQIEVFFKEIFLNILET-STSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQG-R 543
Cdd:PLN03076  440 RAGLKAEIGVFFPMIVLRVLENvAQPNFQQKMIVLRFLDKLCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQGvP 519

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  544 SGHELGMTPLQELSLRKKGLECLVSILKCMVEW-SKDLYVNPNHQTslgqERLMDQEMGDGKG-LDMARRCSVTSMESTV 621
Cdd:PLN03076  520 PGVETTLLPPQEAAMKLEAMKCLVAILRSMGDWmNKQLRLPDPASL----KKLDAVENNLEPGsLPVANGNGDENGEGSD 595

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  622 SSGTQTTIQDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSTR 701
Cdd:PLN03076  596 SHSELSSETSDAATIEQRRAYKLELQEGISLFNRKPKKGIEFLINANKVGESPEEIAAFLKDASGLNKTLIGDYLGERED 675

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  702 FNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNqgQTLFASADTAYVLAYSIIMLTTD 781
Cdd:PLN03076  676 LSLKVMHAYVDSFDFQGMEFDEAIRAFLQGFRLPGEAQKIDRIMEKFAERYCKCN--PKAFSSADTAYVLAYSVIMLNTD 753

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  782 LHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKE-----TKE--------------LTIATKSTK 842
Cdd:PLN03076  754 AHNPMVKNKMSADDFIRNNRGIDDGKDLPEEFMRSLYERISKNEIKMKEddlvpQQKqsansnrilgldsiLNIVIRKRG 833

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  843 QNVASEKQRRLLYNLEMEQMAKTAKAlmEAVshakapFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDDTEVASLCLE 922
Cdd:PLN03076  834 EDSYMETSDDLIKHMQEQFKEKARKS--ESV------YYAATDVVILRFMVEVCWAPMLAAFSVPLDQSDDEVVTFQCLE 905

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  923 GIRCAIRIACIFGMQLERDAYVQALARFSLLTASSSItemKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQ 1002
Cdd:PLN03076  906 GFRHAIHVTAVMSMKTHRDAFVTSLAKFTSLHSPADI---KQKNIDAIKAIVSIADEDGNYLQEAWEHILTCVSRFEHLH 982

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049 1003 LIGTG--------------------VKTRYLSGSGREREGSLKGHTLAGEE--FMGLGLGNLVSGGVDKRQMAS------ 1054
Cdd:PLN03076  983 LLGEGappdatffaapqnesdkskqAKSPILPVLKRKGPGKLQYAAAAVRRgsYDSAGVGGKASGVVTSEQMNNlvsnln 1062

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049 1055 FQESVGETSsqsvvvaVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIW 1134
Cdd:PLN03076 1063 MLEQVGSFE-------MNRIFTRSQKLNSEAIIDFVKALCKVSMEELRSPSDPRVFSLTKIVEIAHYNMNRIRLVWSSIW 1135

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049 1135 HVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMVIRCIAQMVNSQA 1214
Cdd:PLN03076 1136 HVLSDFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVIVMRKSNAVEIRELIIRCVSQMVLSRV 1215

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049 1215 ANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCHIVTTIFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIR 1294
Cdd:PLN03076 1216 NNVKSGWKSMFMVFTTAAYDDHKNIVLLAFEIIEKIIREYFPYITETETTTFTDCVNCLIAFTNSRFNKDISLNAIAFLR 1295

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049 1295 FCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRG----------------WFPILFELSCIINRCKLDVRTRGLTVMFEIM 1358
Cdd:PLN03076 1296 FCATKLAEGDLGSSSRNKDKEAPPSSPQSGKDGkqesgeftdkddhlyfWFPLLAGLSELSFDPRPEIRKSALQVLFDTL 1375

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049 1359 KSYGHTFEKHWWQDLFRIV-FRIFDNMK---------LPEQQSEKSE--------WMTTTCNHALYAICDVFTQFYEALN 1420
Cdd:PLN03076 1376 RNHGHLFSLPLWERVFESVlFPIFDYVRhaidpsggdEPEGQGVDGDqgeldqdaWLYETCTLALQLVVDLFVKFYPTVN 1455

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049 1421 EvLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPEVWDETCNCMLDIFKTTIPHVLLTWRPVGMEEDSSEk 1500
Cdd:PLN03076 1456 P-LLKKVLMLLVSFIKRPHQSLAGIGIAAFVRLMSNAGHLFSDEKWLEVVLSLKEAANATLPDFSYVVSGEYMPAENIQ- 1533

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049 1501 hlDVDLDRQSLSSIDKNPSERGQSqlsnptddswkgrpyanQKLFASLL-IKC--VVQLELIQTIdnivfypatskkeda 1577
Cdd:PLN03076 1534 --DSENAEAASSSTADNDAEAERS-----------------RRLYAAISdAKCraAVQLLLIQAV--------------- 1579

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049 1578 ehmvaaqqdtldadihieTEDQGMYK-YMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSK-PNLLKQET 1655
Cdd:PLN03076 1580 ------------------MEIYNMYRpRLSAKNTLVLFDALHTVASHAHKINSDTALRSKLQELGSMTQMQdPPLLRLEN 1641

                        1770      1780      1790      1800      1810
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 966966049 1656 SSLACCLRILFRMYVDENRRDSWEEIQQRLLTVCSEALAYFItvnsESHREAWTS 1710
Cdd:PLN03076 1642 ESYQICLTFLQNLILDKPPLAKEAEVESRLVELCEEVLQFYI----ETSTAGQDS 1692
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 642-826 6.50e-96

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 307.08  E-value: 6.50e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049   642 QKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSTRFNKEVMYAYVDQLDFCEKEF 721
Cdd:pfam01369    1 RKKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKPDEFNIEVLKAFVDLFDFKGLRI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049   722 VSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGqtLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNR 801
Cdd:pfam01369   81 DEALRLFLESFRLPGEAQKIDRIMEAFAERYYEQNPG--VFANADAAYVLAYSIIMLNTDLHNPNVKKKMTLEDFIRNLR 158

                          170       180
                   ....*....|....*....|....*
gi 966966049   802 GINDSKDLPEEYLSSIYEEIEGKKI 826
Cdd:pfam01369  159 GINDGKDFPDEYLEEIYDSIKKNEI 183
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 642-826 2.95e-85

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 276.41  E-value: 2.95e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  642 QKEIIEHGIELFNKKPKRGIQFLQEQGML-GTSVEDIAQFLHQEERLDSTQVGDFLGDSTRFNKEVMYAYVDQLDFCEKE 720
Cdd:cd00171     1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLeDDSPKEIAKFLYETEGLNKKAIGEYLGENNEFNSLVLHEFVDLFDFSGLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  721 FVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGqTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMN 800
Cdd:cd00171    81 LDEALRKFLQSFRLPGEAQKIDRLLEKFSERYCECNPG-IFSSSADAAYTLAYSIIMLNTDLHNPNVKKKMTLEDFIKNL 159

                         170       180
                  ....*....|....*....|....*.
gi 966966049  801 RGINDSKDLPEEYLSSIYEEIEGKKI 826
Cdd:cd00171   160 RGINDGEDFPREFLKELYDSIKNNEI 185
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 640-826 3.47e-80

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 262.23  E-value: 3.47e-80
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049    640 KQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGT-SVEDIAQFLHQEERLDSTQVGDFLGDSTRFNKEVMYAYVDQLDFCE 718
Cdd:smart00222    2 KGRKKLLSEGIVKFNDKPKKGIQSLQEKGFLANeDPQDVADFLSKNEGLNKKAIGDYLGEHDEFNRLVLHAFVDLFDFSA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049    719 KEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIK 798
Cdd:smart00222   82 KDLDQALREFLESFRLPGEAQKIDRLLEAFSSRYCECNPGVFSKANADAAYTLAYSLIMLNTDLHNPNVKKKMTLEDFIK 161

                           170       180
                    ....*....|....*....|....*...
gi 966966049    799 MNRGINDSKDLPEEYLSSIYEEIEGKKI 826
Cdd:smart00222  162 NVRGSNDGEDLPREFLEELYDSIKNNEI 189
BIG2_C pfam20252
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin ...
 1553-1759 5.61e-58

BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin A-inhibited guanine nucleotide-exchange protein. The function of this region is unknown.


Pssm-ID: 466403  Cd Length: 178  Bit Score: 198.23  E-value: 5.61e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  1553 VVQLELIQTIDNIVfypatskkedaehmvaaqqdtldadihietedQGMYKYMSSQHLFKLLDCLQESHSFSKAFNSNYE 1632
Cdd:pfam20252    1 VVQLLLIQTVNEIL--------------------------------DEHYESLPSDHLLRLLDCLEKSYTFARSFNSDLE 48

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  1633 QRTVLWRAGFkGKSKPNLLKQETSSLACCLRILFRMYVDENRR-DSWEEIQQRLLTVCSEALAYFITVN-SESHRE--AW 1708
Cdd:pfam20252   49 LRTALWRAGF-MKQLPNLLKQETSSLSTYLRILFRLYADDEPRtSQREEVEERLIPLCEDILEYYLSLDeEEKQRElaAW 127

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 966966049  1709 TSLLLLLLTKTLKINDEKFKAHASMYYPYLCEIMQFDLIPELRAVLRKFFL 1759
Cdd:pfam20252  128 TPVVVLILQGLLALPDDDFRRHLPEFYPLLCDLILCELSPEVRLALREFFS 178
Sec7_N pfam12783
Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 ...
 369-524 6.66e-53

Guanine nucleotide exchange factor in Golgi transport N-terminal; The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF.


Pssm-ID: 463703  Cd Length: 154  Bit Score: 182.69  E-value: 6.66e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049   369 LQKDAFLVFRSLCKLS-MKPLGEgpPDPKSHELRSKVVSLQLLLSVLQNAGPVFRTHEMFINAIKQYLCVALSKNGVSSV 447
Cdd:pfam12783    1 AAKDAFLVFRDLCKLSnGKPLSK--SDPKSHAERSKLFSLELIESILENHGDVFLKHPELLQLLKQYLCPSLLRNLSSSS 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966966049   448 PDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILEtSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLN 524
Cdd:pfam12783   79 FPVFVRSLRIFLLLLRRFRSHLKLEIEVFLSLLILPLLE-SDSSLWQKALVLEVLRRLCSDPQLLVEIYLNYDCDLG 154
DCB pfam16213
dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and ...
 28-197 2.92e-41

dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and GIG1-like proteins from metazoa. Mon2 and BIG1 like proteins play an important role in the cytoplasm-to-vacuole transport pathway and are required for Golgi homeostasis.


Pssm-ID: 465072 [Multi-domain]  Cd Length: 172  Bit Score: 150.10  E-value: 2.92e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049    28 QHSQLRRACQVALDEIKAEIEKQ-------------RL---GTAAPPKANFIEA-DKYFLPFELACQSKSPRVVSTSLDC 90
Cdd:pfam16213    1 QGSKLLEALQSDLRTLSSEAKRKyppvkeasekgilRLrtvHSSSPLMQNLLSAsEDILKPFVLACETKNPKLVQIALGC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049    91 LQKLIAYGHITGNApdsgapgkrlIDRIVETICNCFQGPQTdegVQLQIIKALLTAVTSPHIeIHEGTILQTVRTCYNIY 170
Cdd:pfam16213   81 LQKLISHDAISQSA----------APYILDTLWMLMELGSE---IELKVLQTVLLLITTNSV-IHGDTLAKALVLCFRLH 146

                          170       180
                   ....*....|....*....|....*..
gi 966966049   171 LaSKNLINQTTAKATLTQMLNVIFTRM 197
Cdd:pfam16213  147 F-SKDPTVQNTASATLRQLVSVVFERV 172
DUF1981 pfam09324
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized ...
 1166-1247 2.47e-37

Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized domains are found in various plant and yeast protein transport proteins.


Pssm-ID: 462756  Cd Length: 84  Bit Score: 135.31  E-value: 2.47e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966966049  1166 KFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMVIRCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQ 1245
Cdd:pfam09324    1 KFLEKEELSNFKFQKDFLKPFEYIMSNNSSVDVKELVLECILQMIQSKGDNIKSGWKTIFGVLTAAAKDSNESLVRLAFQ 80


                   ..
gi 966966049  1246 TT 1247
Cdd:pfam09324   81 IL 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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