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Conserved domains on  [gi|966965969|ref|XP_015004257|]
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zinc finger protein 217 isoform X1 [Macaca mulatta]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 10443135)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
486-511 9.31e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 9.31e-06
                           10        20
                   ....*....|....*....|....*.
gi 966965969   486 YLNIHLRTHTGEKPYKCEFCDYAAAQ 511
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 751-972 4.63e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 4.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966965969  751 RSRRTGCPPALLG----KDVPPLSSFCKPKPKSAFPAQSKSLPSAKGKQSPPGPGKAPLTSGIDSSTLAP-SNLKSHRPQ 825
Cdd:PHA03247 2682 RPRRRAARPTVGSltslADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPgGPARPARPP 2761

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966965969  826 QNVGVQGAATrqqqsemfPKTSVSPAPDKTKRP-------ETKLKPLPVAPSQPTLGSSNINGSIDYPPKNDSPWAPPgr 898
Cdd:PHA03247 2762 TTAGPPAPAP--------PAAPAAGPPRRLTRPavaslseSRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPP-- 2831

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966965969  899 dyfcnrsasNTAAEFGEPLPKRLKSTVVALDVD-QPGANYRRgydlpkyhmvRGitsllPQECVYPSPALPPKPR 972
Cdd:PHA03247 2832 ---------TSAQPTAPPPPPGPPPPSLPLGGSvAPGGDVRR----------RP-----PSRSPAAKPAAPARPP 2882
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 473-494 6.73e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 6.73e-04
                           10        20
                   ....*....|....*....|..
gi 966965969   473 ECSYCGKFFRSNYYLNIHLRTH 494
Cdd:pfam00096    2 KCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
500-524 6.84e-04

C2H2-type zinc-finger domain;


:

Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 37.92  E-value: 6.84e-04
                           10        20
                   ....*....|....*....|....*
gi 966965969   500 YKCEFCDYAAAQKTSLRYHLERHHK 524
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 159-179 7.23e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 7.23e-03
                           10        20
                   ....*....|....*....|.
gi 966965969   159 CNMCGRRFKEPWFLKNHMRTH 179
Cdd:pfam00096    3 CPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
486-511 9.31e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 9.31e-06
                           10        20
                   ....*....|....*....|....*.
gi 966965969   486 YLNIHLRTHTGEKPYKCEFCDYAAAQ 511
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA03247 PHA03247
large tegument protein UL36; Provisional
 751-972 4.63e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 4.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966965969  751 RSRRTGCPPALLG----KDVPPLSSFCKPKPKSAFPAQSKSLPSAKGKQSPPGPGKAPLTSGIDSSTLAP-SNLKSHRPQ 825
Cdd:PHA03247 2682 RPRRRAARPTVGSltslADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPgGPARPARPP 2761

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966965969  826 QNVGVQGAATrqqqsemfPKTSVSPAPDKTKRP-------ETKLKPLPVAPSQPTLGSSNINGSIDYPPKNDSPWAPPgr 898
Cdd:PHA03247 2762 TTAGPPAPAP--------PAAPAAGPPRRLTRPavaslseSRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPP-- 2831

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966965969  899 dyfcnrsasNTAAEFGEPLPKRLKSTVVALDVD-QPGANYRRgydlpkyhmvRGitsllPQECVYPSPALPPKPR 972
Cdd:PHA03247 2832 ---------TSAQPTAPPPPPGPPPPSLPLGGSvAPGGDVRR----------RP-----PSRSPAAKPAAPARPP 2882
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 473-494 6.73e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 6.73e-04
                           10        20
                   ....*....|....*....|..
gi 966965969   473 ECSYCGKFFRSNYYLNIHLRTH 494
Cdd:pfam00096    2 KCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
500-524 6.84e-04

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 37.92  E-value: 6.84e-04
                           10        20
                   ....*....|....*....|....*
gi 966965969   500 YKCEFCDYAAAQKTSLRYHLERHHK 524
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 159-179 7.23e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 7.23e-03
                           10        20
                   ....*....|....*....|.
gi 966965969   159 CNMCGRRFKEPWFLKNHMRTH 179
Cdd:pfam00096    3 CPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
486-511 9.31e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 9.31e-06
                           10        20
                   ....*....|....*....|....*.
gi 966965969   486 YLNIHLRTHTGEKPYKCEFCDYAAAQ 511
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA03247 PHA03247
large tegument protein UL36; Provisional
 751-972 4.63e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 4.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966965969  751 RSRRTGCPPALLG----KDVPPLSSFCKPKPKSAFPAQSKSLPSAKGKQSPPGPGKAPLTSGIDSSTLAP-SNLKSHRPQ 825
Cdd:PHA03247 2682 RPRRRAARPTVGSltslADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPgGPARPARPP 2761

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966965969  826 QNVGVQGAATrqqqsemfPKTSVSPAPDKTKRP-------ETKLKPLPVAPSQPTLGSSNINGSIDYPPKNDSPWAPPgr 898
Cdd:PHA03247 2762 TTAGPPAPAP--------PAAPAAGPPRRLTRPavaslseSRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPP-- 2831

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966965969  899 dyfcnrsasNTAAEFGEPLPKRLKSTVVALDVD-QPGANYRRgydlpkyhmvRGitsllPQECVYPSPALPPKPR 972
Cdd:PHA03247 2832 ---------TSAQPTAPPPPPGPPPPSLPLGGSvAPGGDVRR----------RP-----PSRSPAAKPAAPARPP 2882
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 473-494 6.73e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 6.73e-04
                           10        20
                   ....*....|....*....|..
gi 966965969   473 ECSYCGKFFRSNYYLNIHLRTH 494
Cdd:pfam00096    2 KCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
500-524 6.84e-04

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 37.92  E-value: 6.84e-04
                           10        20
                   ....*....|....*....|....*
gi 966965969   500 YKCEFCDYAAAQKTSLRYHLERHHK 524
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 159-179 7.23e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 7.23e-03
                           10        20
                   ....*....|....*....|.
gi 966965969   159 CNMCGRRFKEPWFLKNHMRTH 179
Cdd:pfam00096    3 CPDCGKSFSRKSNLKRHLRTH 23
PHA03247 PHA03247
large tegument protein UL36; Provisional
 751-1001 8.40e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 8.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966965969  751 RSRRTGCPPALLGKDVPplssfCKPKPKSAFPAQSKSLPSAKGKQSPPGPGKAPLTSGI-------------DSSTLAPS 817
Cdd:PHA03247 2585 RARRPDAPPQSARPRAP-----VDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPdphppptvppperPRDDPAPG 2659

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966965969  818 NLKSHR--------PQQNVGVQGAATRQQQSEMFPKTSVSPAPDKTKRPETKlkPLPVAPSQPT-LGSSNINGSidYPPK 888
Cdd:PHA03247 2660 RVSRPRrarrlgraAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPA--PHALVSATPLpPGPAAARQA--SPAL 2735

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966965969  889 NDSPWAPPgrdyfcnrSASNTAAEFGEPLPKRLKSTVVALDVDQPGAnyrRGYDLPKYHMVRGITSLLPQECVYPSPALP 968
Cdd:PHA03247 2736 PAAPAPPA--------VPAGPATPGGPARPARPPTTAGPPAPAPPAA---PAAGPPRRLTRPAVASLSESRESLPSPWDP 2804

                         250       260       270
                  ....*....|....*....|....*....|...
gi 966965969  969 PKPRFLSSSEvdSPNVLTVQKPYGGSGPLYTCV 1001
Cdd:PHA03247 2805 ADPPAAVLAP--AAALPPAASPAGPLPPPTSAQ 2835
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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