NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1622841166|ref|XP_015004130|]
View 

transcription initiation factor TFIID subunit 4 [Macaca mulatta]

Protein Classification

TAFH and TAF4 domain-containing protein( domain architecture ID 11167152)

TAFH and TAF4 domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
TAF4 pfam05236
Transcription initiation factor TFIID component TAF4 family; This region of similarity is ...
832-1080 6.85e-119

Transcription initiation factor TFIID component TAF4 family; This region of similarity is found in Transcription initiation factor TFIID component TAF4.


:

Pssm-ID: 461598 [Multi-domain]  Cd Length: 264  Bit Score: 366.21  E-value: 6.85e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  832 INDVASMAGVNLSEESARIL-----ATNSELVGTLTRSCKDETFLLQAPLQRRILEIGKKHGITELHPDVVSYVSHATQQ 906
Cdd:pfam05236    1 LNDVLAMAGVNLREEEERLLssqeaSTNSEAVGTVVRSCKDEPFLNPYPLQRKILEIAKKNGLKEIDPDVLELLSHACEE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  907 RLQNLVEKISETAQQKNFSYKDDDRYEQASDVRAQLKFFEQLDQIEKQRKDEQEREILMRAAKSRSRQEDPEQLRLKQKA 986
Cdd:pfam05236   81 RLRNLLEKLIVISRHRRDGEKTDHRYEQTSDVRKQLKFLAQKDKEEEERRVAEEREGLLKAAKSRSNQEDPEQLKLKQEA 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  987 KEMQQQELAQMRQRDANLTALAAIGPRKKRKVD----CPGPGSGAEGSGPGSVVPGSSGVGAPRQFT------RQRITRV 1056
Cdd:pfam05236  161 KEMQKEEDEKMRHRAANLTALAAIGPRKKKYSWmsssASGSGGGGSGSSKPSSSSGSSSKGTSQTQSsaisreARRIKRV 240
                          250       260
                   ....*....|....*....|....
gi 1622841166 1057 NLRDLIFCLENERETSHSLLLYKA 1080
Cdd:pfam05236  241 TLRDLLFALEQEREGSRSALLYGY 264
TAFH pfam07531
NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the ...
590-673 1.29e-40

NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the product of the nervy gene in Drosophila and the human mtg8b protein, which is hypothesized to be a transcription factor.


:

Pssm-ID: 462195  Cd Length: 90  Bit Score: 144.33  E-value: 1.29e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  590 NVKKCKNFLSTLIKLAssGKQSTETAANVKELVQNLLDGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQLTPDS 669
Cdd:pfam07531    1 NVKKCKNFLSTLIKLA--GEQSPETGENVKELVQGLLNGKIEPEEFTSKLQEELNSSPQPYLVPFLKKSLPALRQELLNS 78

                   ....
gi 1622841166  670 AAFI 673
Cdd:pfam07531   79 ARFI 82
PHA03247 super family cl33720
large tegument protein UL36; Provisional
408-798 8.74e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 8.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  408 QSLPRTPTATTSGIRATLTPTVLAP--RLPQPPQNPTNIQNFQLPPGMVLVRSENGQLLMIPQQALAQMQAQAHAQPQTT 485
Cdd:PHA03247  2595 SARPRAPVDDRGDPRGPAPPSPLPPdtHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAA 2674
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  486 MA--------------------------PRPATPTSAPPVQISTVQAPGTPIIARQVTPTTIIKQVSQAQTTVqPSATLQ 539
Cdd:PHA03247  2675 QAssppqrprrraarptvgsltsladppPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAG-PATPGG 2753
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  540 RSPGVQPQLVLGGAAQTASLGTATavqtGTPQRTVPGATATSSAATETMENVKKcknflSTLIKLASSGKQSTETAAnvk 619
Cdd:PHA03247  2754 PARPARPPTTAGPPAPAPPAAPAA----GPPRRLTRPAVASLSESRESLPSPWD-----PADPPAAVLAPAAALPPA--- 2821
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  620 elvqnlldgkieaedftsrlyrelnSSPQPyLVPFLKRSLPALRQLTPdsaafiqqsqqqpppPASQATTALT-AVVLSS 698
Cdd:PHA03247  2822 -------------------------ASPAG-PLPPPTSAQPTAPPPPP---------------GPPPPSLPLGgSVAPGG 2860
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  699 SVQR--TAGKTAATVTSALQPPVLSLTQPtQVGVGKQGQPTPLVIQQPPKPGALIRPPQVTlTQTPMVALRQPHNRimlt 776
Cdd:PHA03247  2861 DVRRrpPSRSPAAKPAAPARPPVRRLARP-AVSRSTESFALPPDQPERPPQPQAPPPPQPQ-PQPPPPPQPQPPPP---- 2934
                          410       420
                   ....*....|....*....|..
gi 1622841166  777 tPQQIQLNPLQPVPVVKPAVLP 798
Cdd:PHA03247  2935 -PPPRPQPPLAPTTDPAGAGEP 2955
 
Name Accession Description Interval E-value
TAF4 pfam05236
Transcription initiation factor TFIID component TAF4 family; This region of similarity is ...
832-1080 6.85e-119

Transcription initiation factor TFIID component TAF4 family; This region of similarity is found in Transcription initiation factor TFIID component TAF4.


Pssm-ID: 461598 [Multi-domain]  Cd Length: 264  Bit Score: 366.21  E-value: 6.85e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  832 INDVASMAGVNLSEESARIL-----ATNSELVGTLTRSCKDETFLLQAPLQRRILEIGKKHGITELHPDVVSYVSHATQQ 906
Cdd:pfam05236    1 LNDVLAMAGVNLREEEERLLssqeaSTNSEAVGTVVRSCKDEPFLNPYPLQRKILEIAKKNGLKEIDPDVLELLSHACEE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  907 RLQNLVEKISETAQQKNFSYKDDDRYEQASDVRAQLKFFEQLDQIEKQRKDEQEREILMRAAKSRSRQEDPEQLRLKQKA 986
Cdd:pfam05236   81 RLRNLLEKLIVISRHRRDGEKTDHRYEQTSDVRKQLKFLAQKDKEEEERRVAEEREGLLKAAKSRSNQEDPEQLKLKQEA 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  987 KEMQQQELAQMRQRDANLTALAAIGPRKKRKVD----CPGPGSGAEGSGPGSVVPGSSGVGAPRQFT------RQRITRV 1056
Cdd:pfam05236  161 KEMQKEEDEKMRHRAANLTALAAIGPRKKKYSWmsssASGSGGGGSGSSKPSSSSGSSSKGTSQTQSsaisreARRIKRV 240
                          250       260
                   ....*....|....*....|....
gi 1622841166 1057 NLRDLIFCLENERETSHSLLLYKA 1080
Cdd:pfam05236  241 TLRDLLFALEQEREGSRSALLYGY 264
TAFH pfam07531
NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the ...
590-673 1.29e-40

NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the product of the nervy gene in Drosophila and the human mtg8b protein, which is hypothesized to be a transcription factor.


Pssm-ID: 462195  Cd Length: 90  Bit Score: 144.33  E-value: 1.29e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  590 NVKKCKNFLSTLIKLAssGKQSTETAANVKELVQNLLDGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQLTPDS 669
Cdd:pfam07531    1 NVKKCKNFLSTLIKLA--GEQSPETGENVKELVQGLLNGKIEPEEFTSKLQEELNSSPQPYLVPFLKKSLPALRQELLNS 78

                   ....
gi 1622841166  670 AAFI 673
Cdd:pfam07531   79 ARFI 82
HFD_TAF4 cd08045
histone-fold domain found in transcription initiation factor TFIID subunit 4 (TAF4) and ...
867-966 2.70e-37

histone-fold domain found in transcription initiation factor TFIID subunit 4 (TAF4) and similar proteins; TAF4, also called TATA Binding Protein (TBP) associated factor 4, RNA polymerase II TBP-associated factor subunit C, TBP-associated factor 4, transcription initiation factor TFIID 130 kDa subunit (TAF(II)130, TAFII-130, TAFII130), or transcription initiation factor TFIID 135 kDa subunit (TAF(II)135, TAFII-135, TAFII135), is a component of the TFIID complex that is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TFIID is one of the general transcription factors required for accurate and regulated initiation by RNA polymerase II. It plays a central role in mediating promoter responses to various activators and repressors. TAF4 potentiates transcriptional activation by the AF-2S of retinoic acid, vitamin D3 and thyroid hormone. TAF4 also acts as a component of the TFTC-HAT complex and some MLL1/MLL complexes. TAF4 interacts with ATF7 and the interaction inhibits ATF7-mediated transactivation.


Pssm-ID: 467027 [Multi-domain]  Cd Length: 100  Bit Score: 135.05  E-value: 2.70e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  867 DETFLLQAPLQRRILEIGKKHGITELHPDVVSYVSHATQQRLQNLVEKISETAQQKNFSYKDDDRYEQASDVRAQLKFFE 946
Cdd:cd08045      1 EESFLNPPPLQKKIQKIAKKHGLKEVSPDVLSLLSLAVQERLRDLLEKLIVASKHRVDSEKPDYRYEVTSDVRRQLKALE 80
                           90       100
                   ....*....|....*....|
gi 1622841166  947 QLDQIEKQRKDEQEREILMR 966
Cdd:cd08045     81 RLEREEEERRREEERERLLR 100
TAFH smart00549
TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila ...
590-673 1.19e-32

TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila TAF110. Also known as nervy homology region 1 (NHR1).


Pssm-ID: 197785 [Multi-domain]  Cd Length: 92  Bit Score: 121.80  E-value: 1.19e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166   590 NVKKCKNFLSTLIKLASSGKQsTETAANVKELVQNLLDGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQLTPDS 669
Cdd:smart00549    1 NVSKCKRFLTTLIQLSNDISQ-PEVAERVRTLVLGLVNGTITAEEFTSRLQEALNSPLQPYLIPFLKNSLPLLRRELLHC 79

                    ....
gi 1622841166   670 AAFI 673
Cdd:smart00549   80 ARLI 83
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
851-1009 1.38e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.20  E-value: 1.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  851 LATNSELVGTLTRSCKDETFLLQApLQRRILEIgkKHGITELHPDVVSYvshatQQRLQNLVEKISETAQQKNFsYKDDD 930
Cdd:TIGR02168  241 LEELQEELKEAEEELEELTAELQE-LEEKLEEL--RLEVSELEEEIEEL-----QKELYALANEISRLEQQKQI-LRERL 311
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  931 RYEQASDVRAQlkffEQLDQiEKQRKDEQEREILMRAAKSRSRQEDPEQLRLKQKAKEMQQQEL-AQMRQRDANLTALAA 1009
Cdd:TIGR02168  312 ANLERQLEELE----AQLEE-LESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELeSRLEELEEQLETLRS 386
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
902-1009 1.22e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.00  E-value: 1.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  902 HATQQRLQNLVEKISETAQQKNFsykDDDRYEQASDVRAQLKffEQLDQIEKQRKDEQEREIlmrAAKSRSRQEDPEQLR 981
Cdd:COG1196    284 EEAQAEEYELLAELARLEQDIAR---LEERRRELEERLEELE--EELAELEEELEELEEELE---ELEEELEEAEEELEE 355
                           90       100
                   ....*....|....*....|....*...
gi 1622841166  982 LKQKAKEMQQQELAQMRQRDANLTALAA 1009
Cdd:COG1196    356 AEAELAEAEEALLEAEAELAEAEEELEE 383
PHA03247 PHA03247
large tegument protein UL36; Provisional
408-798 8.74e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 8.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  408 QSLPRTPTATTSGIRATLTPTVLAP--RLPQPPQNPTNIQNFQLPPGMVLVRSENGQLLMIPQQALAQMQAQAHAQPQTT 485
Cdd:PHA03247  2595 SARPRAPVDDRGDPRGPAPPSPLPPdtHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAA 2674
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  486 MA--------------------------PRPATPTSAPPVQISTVQAPGTPIIARQVTPTTIIKQVSQAQTTVqPSATLQ 539
Cdd:PHA03247  2675 QAssppqrprrraarptvgsltsladppPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAG-PATPGG 2753
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  540 RSPGVQPQLVLGGAAQTASLGTATavqtGTPQRTVPGATATSSAATETMENVKKcknflSTLIKLASSGKQSTETAAnvk 619
Cdd:PHA03247  2754 PARPARPPTTAGPPAPAPPAAPAA----GPPRRLTRPAVASLSESRESLPSPWD-----PADPPAAVLAPAAALPPA--- 2821
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  620 elvqnlldgkieaedftsrlyrelnSSPQPyLVPFLKRSLPALRQLTPdsaafiqqsqqqpppPASQATTALT-AVVLSS 698
Cdd:PHA03247  2822 -------------------------ASPAG-PLPPPTSAQPTAPPPPP---------------GPPPPSLPLGgSVAPGG 2860
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  699 SVQR--TAGKTAATVTSALQPPVLSLTQPtQVGVGKQGQPTPLVIQQPPKPGALIRPPQVTlTQTPMVALRQPHNRimlt 776
Cdd:PHA03247  2861 DVRRrpPSRSPAAKPAAPARPPVRRLARP-AVSRSTESFALPPDQPERPPQPQAPPPPQPQ-PQPPPPPQPQPPPP---- 2934
                          410       420
                   ....*....|....*....|..
gi 1622841166  777 tPQQIQLNPLQPVPVVKPAVLP 798
Cdd:PHA03247  2935 -PPPRPQPPLAPTTDPAGAGEP 2955
 
Name Accession Description Interval E-value
TAF4 pfam05236
Transcription initiation factor TFIID component TAF4 family; This region of similarity is ...
832-1080 6.85e-119

Transcription initiation factor TFIID component TAF4 family; This region of similarity is found in Transcription initiation factor TFIID component TAF4.


Pssm-ID: 461598 [Multi-domain]  Cd Length: 264  Bit Score: 366.21  E-value: 6.85e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  832 INDVASMAGVNLSEESARIL-----ATNSELVGTLTRSCKDETFLLQAPLQRRILEIGKKHGITELHPDVVSYVSHATQQ 906
Cdd:pfam05236    1 LNDVLAMAGVNLREEEERLLssqeaSTNSEAVGTVVRSCKDEPFLNPYPLQRKILEIAKKNGLKEIDPDVLELLSHACEE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  907 RLQNLVEKISETAQQKNFSYKDDDRYEQASDVRAQLKFFEQLDQIEKQRKDEQEREILMRAAKSRSRQEDPEQLRLKQKA 986
Cdd:pfam05236   81 RLRNLLEKLIVISRHRRDGEKTDHRYEQTSDVRKQLKFLAQKDKEEEERRVAEEREGLLKAAKSRSNQEDPEQLKLKQEA 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  987 KEMQQQELAQMRQRDANLTALAAIGPRKKRKVD----CPGPGSGAEGSGPGSVVPGSSGVGAPRQFT------RQRITRV 1056
Cdd:pfam05236  161 KEMQKEEDEKMRHRAANLTALAAIGPRKKKYSWmsssASGSGGGGSGSSKPSSSSGSSSKGTSQTQSsaisreARRIKRV 240
                          250       260
                   ....*....|....*....|....
gi 1622841166 1057 NLRDLIFCLENERETSHSLLLYKA 1080
Cdd:pfam05236  241 TLRDLLFALEQEREGSRSALLYGY 264
TAFH pfam07531
NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the ...
590-673 1.29e-40

NHR1 homology to TAF; This corresponds to the region NHR1 that is conserved between the product of the nervy gene in Drosophila and the human mtg8b protein, which is hypothesized to be a transcription factor.


Pssm-ID: 462195  Cd Length: 90  Bit Score: 144.33  E-value: 1.29e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  590 NVKKCKNFLSTLIKLAssGKQSTETAANVKELVQNLLDGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQLTPDS 669
Cdd:pfam07531    1 NVKKCKNFLSTLIKLA--GEQSPETGENVKELVQGLLNGKIEPEEFTSKLQEELNSSPQPYLVPFLKKSLPALRQELLNS 78

                   ....
gi 1622841166  670 AAFI 673
Cdd:pfam07531   79 ARFI 82
HFD_TAF4 cd08045
histone-fold domain found in transcription initiation factor TFIID subunit 4 (TAF4) and ...
867-966 2.70e-37

histone-fold domain found in transcription initiation factor TFIID subunit 4 (TAF4) and similar proteins; TAF4, also called TATA Binding Protein (TBP) associated factor 4, RNA polymerase II TBP-associated factor subunit C, TBP-associated factor 4, transcription initiation factor TFIID 130 kDa subunit (TAF(II)130, TAFII-130, TAFII130), or transcription initiation factor TFIID 135 kDa subunit (TAF(II)135, TAFII-135, TAFII135), is a component of the TFIID complex that is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TFIID is one of the general transcription factors required for accurate and regulated initiation by RNA polymerase II. It plays a central role in mediating promoter responses to various activators and repressors. TAF4 potentiates transcriptional activation by the AF-2S of retinoic acid, vitamin D3 and thyroid hormone. TAF4 also acts as a component of the TFTC-HAT complex and some MLL1/MLL complexes. TAF4 interacts with ATF7 and the interaction inhibits ATF7-mediated transactivation.


Pssm-ID: 467027 [Multi-domain]  Cd Length: 100  Bit Score: 135.05  E-value: 2.70e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  867 DETFLLQAPLQRRILEIGKKHGITELHPDVVSYVSHATQQRLQNLVEKISETAQQKNFSYKDDDRYEQASDVRAQLKFFE 946
Cdd:cd08045      1 EESFLNPPPLQKKIQKIAKKHGLKEVSPDVLSLLSLAVQERLRDLLEKLIVASKHRVDSEKPDYRYEVTSDVRRQLKALE 80
                           90       100
                   ....*....|....*....|
gi 1622841166  947 QLDQIEKQRKDEQEREILMR 966
Cdd:cd08045     81 RLEREEEERRREEERERLLR 100
TAFH smart00549
TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila ...
590-673 1.19e-32

TAF homology; Domain in Drosophila nervy, CBFA2T1, human TAF105, human TAF130, and Drosophila TAF110. Also known as nervy homology region 1 (NHR1).


Pssm-ID: 197785 [Multi-domain]  Cd Length: 92  Bit Score: 121.80  E-value: 1.19e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166   590 NVKKCKNFLSTLIKLASSGKQsTETAANVKELVQNLLDGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQLTPDS 669
Cdd:smart00549    1 NVSKCKRFLTTLIQLSNDISQ-PEVAERVRTLVLGLVNGTITAEEFTSRLQEALNSPLQPYLIPFLKNSLPLLRRELLHC 79

                    ....
gi 1622841166   670 AAFI 673
Cdd:smart00549   80 ARLI 83
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
905-1000 7.36e-05

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 46.07  E-value: 7.36e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  905 QQRLQNLVEKISETAQQKnfsykdDDRYEqasdVRAQLkFFEQLDQIEKQR-KDEQEREILMRAAKSRSRQEdpeQLRLK 983
Cdd:pfam13868  183 EREIARLRAQQEKAQDEK------AERDE----LRAKL-YQEEQERKERQKeREEAEKKARQRQELQQAREE---QIELK 248
                           90
                   ....*....|....*..
gi 1622841166  984 QKAKEMQQQELAQMRQR 1000
Cdd:pfam13868  249 ERRLAEEAEREEEEFER 265
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
851-1009 1.38e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.20  E-value: 1.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  851 LATNSELVGTLTRSCKDETFLLQApLQRRILEIgkKHGITELHPDVVSYvshatQQRLQNLVEKISETAQQKNFsYKDDD 930
Cdd:TIGR02168  241 LEELQEELKEAEEELEELTAELQE-LEEKLEEL--RLEVSELEEEIEEL-----QKELYALANEISRLEQQKQI-LRERL 311
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  931 RYEQASDVRAQlkffEQLDQiEKQRKDEQEREILMRAAKSRSRQEDPEQLRLKQKAKEMQQQEL-AQMRQRDANLTALAA 1009
Cdd:TIGR02168  312 ANLERQLEELE----AQLEE-LESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELeSRLEELEEQLETLRS 386
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
905-1000 1.07e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 42.60  E-value: 1.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  905 QQRLQNLVEKISETAQ--QKNFSYKDDDRYEQASDVRAQLKFFEQLDQIEKQRKD------EQEREILMRAA-----KSR 971
Cdd:pfam13868   87 QKRQEEYEEKLQEREQmdEIVERIQEEDQAEAEEKLEKQRQLREEIDEFNEEQAEwkelekEEEREEDERILeylkeKAE 166
                           90       100
                   ....*....|....*....|....*....
gi 1622841166  972 SRQEDPEQLRLKQKAKEMQQQELAQMRQR 1000
Cdd:pfam13868  167 REEEREAEREEIEEEKEREIARLRAQQEK 195
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
902-1009 1.22e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.00  E-value: 1.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  902 HATQQRLQNLVEKISETAQQKNFsykDDDRYEQASDVRAQLKffEQLDQIEKQRKDEQEREIlmrAAKSRSRQEDPEQLR 981
Cdd:COG1196    284 EEAQAEEYELLAELARLEQDIAR---LEERRRELEERLEELE--EELAELEEELEELEEELE---ELEEELEEAEEELEE 355
                           90       100
                   ....*....|....*....|....*...
gi 1622841166  982 LKQKAKEMQQQELAQMRQRDANLTALAA 1009
Cdd:COG1196    356 AEAELAEAEEALLEAEAELAEAEEELEE 383
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
902-1000 2.60e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 41.44  E-value: 2.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  902 HATQQRLQNLVEKISEtaQQKNFSYKDDDRyEQASDVRAqLKFFEQLDQIEKQRKDEQEREILMRA----------AKSR 971
Cdd:pfam13868  122 LEKQRQLREEIDEFNE--EQAEWKELEKEE-EREEDERI-LEYLKEKAEREEEREAEREEIEEEKEreiarlraqqEKAQ 197
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1622841166  972 SRQEDPEQLRLK----QKAKEMQQQELAQMRQR 1000
Cdd:pfam13868  198 DEKAERDELRAKlyqeEQERKERQKEREEAEKK 230
RRP36 pfam06102
rRNA biogenesis protein RRP36; RRP36 is involved in the early processing steps of the pre-rRNA.
911-991 6.88e-03

rRNA biogenesis protein RRP36; RRP36 is involved in the early processing steps of the pre-rRNA.


Pssm-ID: 461829 [Multi-domain]  Cd Length: 158  Bit Score: 38.31  E-value: 6.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  911 LVEKISETAQQKNFSYKDDDRYEQASDVRAQLKffeqldqiekQRKDEQEREILMRA-------AKSRSRQEDPEQLRLK 983
Cdd:pfam06102   38 LSGEFDEDKFRKNYGFLDEYRKKEIEELKKQLK----------KTKDPEEKEELKRTlqsmesrLKAKKRKDREREVLKE 107

                   ....*...
gi 1622841166  984 QKAKEMQQ 991
Cdd:pfam06102  108 HKKEEKEK 115
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
905-1000 7.53e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 39.90  E-value: 7.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  905 QQRLQNLVEKisETAQQKnfsYKDDDRyEQASDVRAQLKFFEQLDQIEKQRKDEQE----REILM-----RAAKSRSRQE 975
Cdd:pfam13868  239 QAREEQIELK--ERRLAE---EAEREE-EEFERMLRKQAEDEEIEQEEAEKRRMKRlehrRELEKqieerEEQRAAEREE 312
                           90       100
                   ....*....|....*....|....*
gi 1622841166  976 DPEQLRLKQKAKEMQQQELAQMRQR 1000
Cdd:pfam13868  313 ELEEGERLREEEAERRERIEEERQK 337
PHA03247 PHA03247
large tegument protein UL36; Provisional
408-798 8.74e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 8.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  408 QSLPRTPTATTSGIRATLTPTVLAP--RLPQPPQNPTNIQNFQLPPGMVLVRSENGQLLMIPQQALAQMQAQAHAQPQTT 485
Cdd:PHA03247  2595 SARPRAPVDDRGDPRGPAPPSPLPPdtHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAA 2674
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  486 MA--------------------------PRPATPTSAPPVQISTVQAPGTPIIARQVTPTTIIKQVSQAQTTVqPSATLQ 539
Cdd:PHA03247  2675 QAssppqrprrraarptvgsltsladppPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAG-PATPGG 2753
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  540 RSPGVQPQLVLGGAAQTASLGTATavqtGTPQRTVPGATATSSAATETMENVKKcknflSTLIKLASSGKQSTETAAnvk 619
Cdd:PHA03247  2754 PARPARPPTTAGPPAPAPPAAPAA----GPPRRLTRPAVASLSESRESLPSPWD-----PADPPAAVLAPAAALPPA--- 2821
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  620 elvqnlldgkieaedftsrlyrelnSSPQPyLVPFLKRSLPALRQLTPdsaafiqqsqqqpppPASQATTALT-AVVLSS 698
Cdd:PHA03247  2822 -------------------------ASPAG-PLPPPTSAQPTAPPPPP---------------GPPPPSLPLGgSVAPGG 2860
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  699 SVQR--TAGKTAATVTSALQPPVLSLTQPtQVGVGKQGQPTPLVIQQPPKPGALIRPPQVTlTQTPMVALRQPHNRimlt 776
Cdd:PHA03247  2861 DVRRrpPSRSPAAKPAAPARPPVRRLARP-AVSRSTESFALPPDQPERPPQPQAPPPPQPQ-PQPPPPPQPQPPPP---- 2934
                          410       420
                   ....*....|....*....|..
gi 1622841166  777 tPQQIQLNPLQPVPVVKPAVLP 798
Cdd:PHA03247  2935 -PPPRPQPPLAPTTDPAGAGEP 2955
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
870-1009 9.25e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.14  E-value: 9.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  870 FLLQAPLQRRILEIGKKHG----------------ITELHPDVVSYvsHATQQRLQNLVEKISETAQQKNFSYKDDDRYE 933
Cdd:COG4717     45 AMLLERLEKEADELFKPQGrkpelnlkelkeleeeLKEAEEKEEEY--AELQEELEELEEELEELEAELEELREELEKLE 122
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841166  934 QASDVRAQLKFFEQL--------DQIEKQRKDEQEREILMRAAKSRSRQEDPEQLRLKQKAKEMQQQELAQMRQRDANLT 1005
Cdd:COG4717    123 KLLQLLPLYQELEALeaelaelpERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELE 202

                   ....
gi 1622841166 1006 ALAA 1009
Cdd:COG4717    203 ELQQ 206
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH