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Conserved domains on  [gi|1622966949|ref|XP_015003416|]
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protein transport protein Sec31B isoform X2 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 84-339 3.63e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 121.67  E-value: 3.63e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949   84 SSGVIAGGGDNGMLILYNVThilssGKEPVIAQKQkHTGAVRALDFNPFqvlqGNLLASGASDSEVFIWDLNNLNVPMTL 163
Cdd:cd00200     20 DGKLLATGSGDGTIKVWDLE-----TGELLRTLKG-HTGPVRDVAASAD----GTYLASGSSDKTIRLWDLETGECVRTL 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  164 GSKSQYseppedVKALSWNrQAQHILSSAHPSGKAVVWDLRKNEPIIKVSDHSNRMHCsgLAWHPDiaTQLVLCSEDDRL 243
Cdd:cd00200     90 TGHTSY------VSSVAFS-PDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNS--VAFSPD--GTFVASSSQDGT 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  244 pvIQLWDLRfASSPLKVLESHSRGILSVSWSqADAELLLTSAKDSQILCLNLESSEVVYKLPTQSSWCFEVQWCPrDPSV 323
Cdd:cd00200    159 --IKLWDLR-TGKCVATLTGHTGEVNSVAFS-PDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYL 233

                          250
                   ....*....|....*.
gi 1622966949  324 FSAASFDGWISLYSVM 339
Cdd:cd00200    234 LASGSEDGTIRVWDLR 249
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 774-1081 9.91e-09

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.95  E-value: 9.91e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  774 PPVQQLRDRLFHAQGSAVLGQQSPPFPYPRIVVGAIPHSKETSyRLGSQPSHQVPTPSPRPRVFTPQSSPAMPLAPSHPS 853
Cdd:PHA03247  2626 PPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRAR-RLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPP 2704

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  854 PYQgprmqnisdyrasgsqaiqPLPLGPGVRPASSQPQLLGGQRVQAPNPVGFPGTWPLPGSLLLMACPdiTQPGSTSLS 933
Cdd:PHA03247  2705 PPT-------------------PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGP--ARPARPPTT 2763

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  934 ETPRlfpllplrppgpshmvshAPAPPVSFLVPYPPGGPVAPCSSVLPTTGILTPHPGPQDSWKEAPAPGGNLQRNKLPE 1013
Cdd:PHA03247  2764 AGPP------------------APAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA 2825

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622966949 1014 TFMAPAPITAPVMSLTPE--LQGILPLQ---PPVSGVSHAPPGAPGELSLQQLQHLPPEKMERKELPPEHQSL 1081
Cdd:PHA03247  2826 GPLPPPTSAQPTAPPPPPgpPPPSLPLGgsvAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESF 2898
ACE1-Sec16-like super family cl14807
Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat ...
 574-694 1.38e-04

Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat complex plays an important role in vesicular traffic of newly synthezised proteins from the endoplasmatic reticulum (ER) to the Golgi apparatus by mediating the formation of transport vesicles. COPII consists of an outer coat, made up of the scaffold proteins Sec31 and Sec13, and the cargo adaptor complex, Sec23 and Sec24, which are recruited by the small GTPase Sar1. Sec16 is involved in the early steps of the assembly process. Sec16 forms elongated heterotetramers with Sec13, Sec13-(Sec16)2-Sec13. It interacts with Sec13 by insertion of a single beta-blade to close the six-bladded beta propeller of Sec13. In the same way Sec13 interacts with Sec31 and Nup145C, a nuclear pore protein, all of these contain a structurally related ancestral coatomer element 1 (ACE1). Sec16 is believed to be a key component in maintaining the integrity of the ER exit site.


The actual alignment was detected with superfamily member cd09233:

Pssm-ID: 449359 [Multi-domain]  Cd Length: 314  Bit Score: 45.33  E-value: 1.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  574 LLLGELGPAVELYLKEERFADAIILAQAGGADLLKQTQERYlAKKKTKISSLLACVVQ---KNWKDVVCTCS-------- 642
Cdd:cd09233     73 LLTGNRKEALELALDNGLWAHALLLASSLGKETWAEVVSRF-ARSESKLNDPLQTLYQlfsGNSPEAITELAdnpaeaew 151

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622966949  643 -LKNWREALALLLTYSSTEKfpelcDM-----LGTRMEQEGgraLTSEARLCYVCSGS 694
Cdd:cd09233    152 aLGNWREHLAIILSNRTSNL-----DLealveLGDLLAQRG---LVEAAHICYLLAGV 201
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 84-339 3.63e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 121.67  E-value: 3.63e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949   84 SSGVIAGGGDNGMLILYNVThilssGKEPVIAQKQkHTGAVRALDFNPFqvlqGNLLASGASDSEVFIWDLNNLNVPMTL 163
Cdd:cd00200     20 DGKLLATGSGDGTIKVWDLE-----TGELLRTLKG-HTGPVRDVAASAD----GTYLASGSSDKTIRLWDLETGECVRTL 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  164 GSKSQYseppedVKALSWNrQAQHILSSAHPSGKAVVWDLRKNEPIIKVSDHSNRMHCsgLAWHPDiaTQLVLCSEDDRL 243
Cdd:cd00200     90 TGHTSY------VSSVAFS-PDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNS--VAFSPD--GTFVASSSQDGT 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  244 pvIQLWDLRfASSPLKVLESHSRGILSVSWSqADAELLLTSAKDSQILCLNLESSEVVYKLPTQSSWCFEVQWCPrDPSV 323
Cdd:cd00200    159 --IKLWDLR-TGKCVATLTGHTGEVNSVAFS-PDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYL 233

                          250
                   ....*....|....*.
gi 1622966949  324 FSAASFDGWISLYSVM 339
Cdd:cd00200    234 LASGSEDGTIRVWDLR 249
WD40 COG2319
WD40 repeat [General function prediction only];
6-338 3.82e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.39  E-value: 3.82e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949    6 LERPAVQAWSPASQYPLYLATGTSAQQLDSSFSTNGTLEIFEVDFRDPSLDLKHKGVLSASSRFHklIWGSFGSGLLESS 85
Cdd:COG2319     13 SADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGH--TAAVLSVAFSPDG 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949   86 GVIAGGGDNGMLILYNVthilSSGKEPviAQKQKHTGAVRALDFNPfqvlQGNLLASGASDSEVFIWDLNNLNVPMTLgs 165
Cdd:COG2319     91 RLLASASADGTVRLWDL----ATGLLL--RTLTGHTGAVRSVAFSP----DGKTLASGSADGTVRLWDLATGKLLRTL-- 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  166 ksqySEPPEDVKALSWNRQAQhILSSAHPSGKAVVWDLRKNEPIIKVSDHSNRMHCsgLAWHPDiATQLVLCSEDDRlpv 245
Cdd:COG2319    159 ----TGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS--VAFSPD-GKLLASGSADGT--- 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  246 IQLWDLRfASSPLKVLESHSRGILSVSWSqADAELLLTSAKDSQILCLNLESSEVVYKLPTQSSWCFEVQWCPrDPSVFS 325
Cdd:COG2319    228 VRLWDLA-TGKLLRTLTGHSGSVRSVAFS-PDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLA 304

                          330
                   ....*....|...
gi 1622966949  326 AASFDGWISLYSV 338
Cdd:COG2319    305 SGSDDGTVRLWDL 317
PHA03247 PHA03247
large tegument protein UL36; Provisional
 774-1081 9.91e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.95  E-value: 9.91e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  774 PPVQQLRDRLFHAQGSAVLGQQSPPFPYPRIVVGAIPHSKETSyRLGSQPSHQVPTPSPRPRVFTPQSSPAMPLAPSHPS 853
Cdd:PHA03247  2626 PPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRAR-RLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPP 2704

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  854 PYQgprmqnisdyrasgsqaiqPLPLGPGVRPASSQPQLLGGQRVQAPNPVGFPGTWPLPGSLLLMACPdiTQPGSTSLS 933
Cdd:PHA03247  2705 PPT-------------------PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGP--ARPARPPTT 2763

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  934 ETPRlfpllplrppgpshmvshAPAPPVSFLVPYPPGGPVAPCSSVLPTTGILTPHPGPQDSWKEAPAPGGNLQRNKLPE 1013
Cdd:PHA03247  2764 AGPP------------------APAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA 2825

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622966949 1014 TFMAPAPITAPVMSLTPE--LQGILPLQ---PPVSGVSHAPPGAPGELSLQQLQHLPPEKMERKELPPEHQSL 1081
Cdd:PHA03247  2826 GPLPPPTSAQPTAPPPPPgpPPPSLPLGgsvAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESF 2898
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 828-1066 4.67e-08

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 57.47  E-value: 4.67e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  828 PTPSPRPRVFTPQSSPAMPLAPSHPSPYQGPR--MQNISDYRA----SGSQAIQPLPLGPgvRPASSQPQLLGGQRVQAP 901
Cdd:pfam03154  197 AGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHtlIQQTPTLHPqrlpSPHPPLQPMTQPP--PPSQVSPQPLPQPSLHGQ 274

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  902 NPvgfPGTWPLPGSLLLMACPDITQP-GSTSLSETPRLFPLLPLRPPGPSHMVSHAPAPPVSFLVPYPPGgpvapcSSVL 980
Cdd:pfam03154  275 MP---PMPHSLQTGPSHMQHPVPPQPfPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPR------EQPL 345

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  981 PTTGILTPH--PGPQDSWKEAPAPggnlQRNKLPETFMAPAPITAPVmSLTPElqgilPLQPPVSGVS-HAPPGA-PGEL 1056
Cdd:pfam03154  346 PPAPLSMPHikPPPTTPIPQLPNP----QSHKHPPHLSGPSPFQMNS-NLPPP-----PALKPLSSLStHHPPSAhPPPL 415

                          250
                   ....*....|.
gi 1622966949 1057 SLQ-QLQHLPP 1066
Cdd:pfam03154  416 QLMpQSQQLPP 426
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 120-153 7.73e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 7.73e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1622966949   120 HTGAVRALDFNPfqvlQGNLLASGASDSEVFIWD 153
Cdd:smart00320   11 HTGPVTSVAFSP----DGKYLASGSDDGTIKLWD 40
ACE1-Sec16-like cd09233
Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat ...
 574-694 1.38e-04

Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat complex plays an important role in vesicular traffic of newly synthezised proteins from the endoplasmatic reticulum (ER) to the Golgi apparatus by mediating the formation of transport vesicles. COPII consists of an outer coat, made up of the scaffold proteins Sec31 and Sec13, and the cargo adaptor complex, Sec23 and Sec24, which are recruited by the small GTPase Sar1. Sec16 is involved in the early steps of the assembly process. Sec16 forms elongated heterotetramers with Sec13, Sec13-(Sec16)2-Sec13. It interacts with Sec13 by insertion of a single beta-blade to close the six-bladded beta propeller of Sec13. In the same way Sec13 interacts with Sec31 and Nup145C, a nuclear pore protein, all of these contain a structurally related ancestral coatomer element 1 (ACE1). Sec16 is believed to be a key component in maintaining the integrity of the ER exit site.


Pssm-ID: 187750 [Multi-domain]  Cd Length: 314  Bit Score: 45.33  E-value: 1.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  574 LLLGELGPAVELYLKEERFADAIILAQAGGADLLKQTQERYlAKKKTKISSLLACVVQ---KNWKDVVCTCS-------- 642
Cdd:cd09233     73 LLTGNRKEALELALDNGLWAHALLLASSLGKETWAEVVSRF-ARSESKLNDPLQTLYQlfsGNSPEAITELAdnpaeaew 151

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622966949  643 -LKNWREALALLLTYSSTEKfpelcDM-----LGTRMEQEGgraLTSEARLCYVCSGS 694
Cdd:cd09233    152 aLGNWREHLAIILSNRTSNL-----DLealveLGDLLAQRG---LVEAAHICYLLAGV 201
PTZ00420 PTZ00420
coronin; Provisional
 80-207 2.41e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 45.33  E-value: 2.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949   80 GLLESSGVIA------GGGDNGMLILYNVTHilssgKEPVIAQKqKHTGAVRALDFNPfqvLQGNLLASGASDSEVFIWD 153
Cdd:PTZ00420    33 GIACSSGFVAvpweveGGGLIGAIRLENQMR-----KPPVIKLK-GHTSSILDLQFNP---CFSEILASGSEDLTIRVWE 103

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622966949  154 L--NNLNVPMTLGSKSQYSEPPEDVKALSWNRQAQHILSSAHPSGKAVVWDLrKNE 207
Cdd:PTZ00420   104 IphNDESVKEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDI-ENE 158
WD40 pfam00400
WD domain, G-beta repeat;
120-153 5.44e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 5.44e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1622966949  120 HTGAVRALDFNPfqvlQGNLLASGASDSEVFIWD 153
Cdd:pfam00400   10 HTGSVTSLAFSP----DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 84-339 3.63e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 121.67  E-value: 3.63e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949   84 SSGVIAGGGDNGMLILYNVThilssGKEPVIAQKQkHTGAVRALDFNPFqvlqGNLLASGASDSEVFIWDLNNLNVPMTL 163
Cdd:cd00200     20 DGKLLATGSGDGTIKVWDLE-----TGELLRTLKG-HTGPVRDVAASAD----GTYLASGSSDKTIRLWDLETGECVRTL 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  164 GSKSQYseppedVKALSWNrQAQHILSSAHPSGKAVVWDLRKNEPIIKVSDHSNRMHCsgLAWHPDiaTQLVLCSEDDRL 243
Cdd:cd00200     90 TGHTSY------VSSVAFS-PDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNS--VAFSPD--GTFVASSSQDGT 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  244 pvIQLWDLRfASSPLKVLESHSRGILSVSWSqADAELLLTSAKDSQILCLNLESSEVVYKLPTQSSWCFEVQWCPrDPSV 323
Cdd:cd00200    159 --IKLWDLR-TGKCVATLTGHTGEVNSVAFS-PDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYL 233

                          250
                   ....*....|....*.
gi 1622966949  324 FSAASFDGWISLYSVM 339
Cdd:cd00200    234 LASGSEDGTIRVWDLR 249
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-337 4.87e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 121.29  E-value: 4.87e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949   13 AWSPASQYplyLATGtsaqqldssfSTNGTLEIFEVDFRDPSLDLK-HKGVLSassrfhKLIWGSFGSgllessgVIAGG 91
Cdd:cd00200     16 AFSPDGKL---LATG----------SGDGTIKVWDLETGELLRTLKgHTGPVR------DVAASADGT-------YLASG 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949   92 GDNGMLILYNVthilsSGKEPVIAQKQkHTGAVRALDFNPfqvlQGNLLASGASDSEVFIWDLNNLNVPMTLGSKSQyse 171
Cdd:cd00200     70 SSDKTIRLWDL-----ETGECVRTLTG-HTSYVSSVAFSP----DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD--- 136

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  172 ppeDVKALSWNrQAQHILSSAHPSGKAVVWDLRKNEPIIKVSDHSNRMHCsgLAWHPDiATQLVLCSEDDrlpVIQLWDL 251
Cdd:cd00200    137 ---WVNSVAFS-PDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNS--VAFSPD-GEKLLSSSSDG---TIKLWDL 206

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  252 RfASSPLKVLESHSRGILSVSWSQaDAELLLTSAKDSQILCLNLESSEVVYKLPTQSSWCFEVQWCPRDPSVFSaASFDG 331
Cdd:cd00200    207 S-TGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLAS-GSADG 283


                   ....*.
gi 1622966949  332 WISLYS 337
Cdd:cd00200    284 TIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
6-338 3.82e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.39  E-value: 3.82e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949    6 LERPAVQAWSPASQYPLYLATGTSAQQLDSSFSTNGTLEIFEVDFRDPSLDLKHKGVLSASSRFHklIWGSFGSGLLESS 85
Cdd:COG2319     13 SADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGH--TAAVLSVAFSPDG 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949   86 GVIAGGGDNGMLILYNVthilSSGKEPviAQKQKHTGAVRALDFNPfqvlQGNLLASGASDSEVFIWDLNNLNVPMTLgs 165
Cdd:COG2319     91 RLLASASADGTVRLWDL----ATGLLL--RTLTGHTGAVRSVAFSP----DGKTLASGSADGTVRLWDLATGKLLRTL-- 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  166 ksqySEPPEDVKALSWNRQAQhILSSAHPSGKAVVWDLRKNEPIIKVSDHSNRMHCsgLAWHPDiATQLVLCSEDDRlpv 245
Cdd:COG2319    159 ----TGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS--VAFSPD-GKLLASGSADGT--- 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  246 IQLWDLRfASSPLKVLESHSRGILSVSWSqADAELLLTSAKDSQILCLNLESSEVVYKLPTQSSWCFEVQWCPrDPSVFS 325
Cdd:COG2319    228 VRLWDLA-TGKLLRTLTGHSGSVRSVAFS-PDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLA 304

                          330
                   ....*....|...
gi 1622966949  326 AASFDGWISLYSV 338
Cdd:COG2319    305 SGSDDGTVRLWDL 317
WD40 COG2319
WD40 repeat [General function prediction only];
88-338 9.84e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 114.24  E-value: 9.84e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949   88 IAGGGDNGMLILYNVThilsSGKEpvIAQKQKHTGAVRALDFNPfqvlQGNLLASGASDSEVFIWDLNNLNVPMTLGSKS 167
Cdd:COG2319    177 LASGSDDGTVRLWDLA----TGKL--LRTLTGHTGAVRSVAFSP----DGKLLASGSADGTVRLWDLATGKLLRTLTGHS 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  168 QYseppedVKALSWNRQAQHILsSAHPSGKAVVWDLRKNEPIIKVSDHSNRMHcsGLAWHPDiATQLVLCSEDDRlpvIQ 247
Cdd:COG2319    247 GS------VRSVAFSPDGRLLA-SGSADGTVRLWDLATGELLRTLTGHSGGVN--SVAFSPD-GKLLASGSDDGT---VR 313

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  248 LWDLRfASSPLKVLESHSRGILSVSWSqADAELLLTSAKDSQILCLNLESSEVVYKLPTQSSWCFEVQWCPrDPSVFSAA 327
Cdd:COG2319    314 LWDLA-TGKLLRTLTGHTGAVRSVAFS-PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASG 390

                          250
                   ....*....|.
gi 1622966949  328 SFDGWISLYSV 338
Cdd:COG2319    391 SADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
88-338 2.39e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.00  E-value: 2.39e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949   88 IAGGGDNGMLILYNvthiLSSGKEpvIAQKQKHTGAVRALDFNPfqvlQGNLLASGASDSEVFIWDLNNLNVPMTLgsks 167
Cdd:COG2319    135 LASGSADGTVRLWD----LATGKL--LRTLTGHSGAVTSVAFSP----DGKLLASGSDDGTVRLWDLATGKLLRTL---- 200

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  168 qySEPPEDVKALSWNRQAQhILSSAHPSGKAVVWDLRKNEPIIKVSDHSNRMHCsgLAWHPDiATQLVLCSEDDRlpvIQ 247
Cdd:COG2319    201 --TGHTGAVRSVAFSPDGK-LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRS--VAFSPD-GRLLASGSADGT---VR 271

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  248 LWDLRfASSPLKVLESHSRGILSVSWSqADAELLLTSAKDSQILCLNLESSEVVYKLPTQSSWCFEVQWCPRDPSVFSaA 327
Cdd:COG2319    272 LWDLA-TGELLRTLTGHSGGVNSVAFS-PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS-G 348

                          250
                   ....*....|.
gi 1622966949  328 SFDGWISLYSV 338
Cdd:COG2319    349 SDDGTVRLWDL 359
PHA03247 PHA03247
large tegument protein UL36; Provisional
 774-1081 9.91e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.95  E-value: 9.91e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  774 PPVQQLRDRLFHAQGSAVLGQQSPPFPYPRIVVGAIPHSKETSyRLGSQPSHQVPTPSPRPRVFTPQSSPAMPLAPSHPS 853
Cdd:PHA03247  2626 PPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRAR-RLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPP 2704

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  854 PYQgprmqnisdyrasgsqaiqPLPLGPGVRPASSQPQLLGGQRVQAPNPVGFPGTWPLPGSLLLMACPdiTQPGSTSLS 933
Cdd:PHA03247  2705 PPT-------------------PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGP--ARPARPPTT 2763

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  934 ETPRlfpllplrppgpshmvshAPAPPVSFLVPYPPGGPVAPCSSVLPTTGILTPHPGPQDSWKEAPAPGGNLQRNKLPE 1013
Cdd:PHA03247  2764 AGPP------------------APAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA 2825

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622966949 1014 TFMAPAPITAPVMSLTPE--LQGILPLQ---PPVSGVSHAPPGAPGELSLQQLQHLPPEKMERKELPPEHQSL 1081
Cdd:PHA03247  2826 GPLPPPTSAQPTAPPPPPgpPPPSLPLGgsvAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESF 2898
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 828-1066 4.67e-08

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 57.47  E-value: 4.67e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  828 PTPSPRPRVFTPQSSPAMPLAPSHPSPYQGPR--MQNISDYRA----SGSQAIQPLPLGPgvRPASSQPQLLGGQRVQAP 901
Cdd:pfam03154  197 AGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHtlIQQTPTLHPqrlpSPHPPLQPMTQPP--PPSQVSPQPLPQPSLHGQ 274

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  902 NPvgfPGTWPLPGSLLLMACPDITQP-GSTSLSETPRLFPLLPLRPPGPSHMVSHAPAPPVSFLVPYPPGgpvapcSSVL 980
Cdd:pfam03154  275 MP---PMPHSLQTGPSHMQHPVPPQPfPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPR------EQPL 345

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  981 PTTGILTPH--PGPQDSWKEAPAPggnlQRNKLPETFMAPAPITAPVmSLTPElqgilPLQPPVSGVS-HAPPGA-PGEL 1056
Cdd:pfam03154  346 PPAPLSMPHikPPPTTPIPQLPNP----QSHKHPPHLSGPSPFQMNS-NLPPP-----PALKPLSSLStHHPPSAhPPPL 415

                          250
                   ....*....|.
gi 1622966949 1057 SLQ-QLQHLPP 1066
Cdd:pfam03154  416 QLMpQSQQLPP 426
PHA03247 PHA03247
large tegument protein UL36; Provisional
 794-1076 5.72e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.64  E-value: 5.72e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  794 QQSPPFPYPRIVVGAiphsketsyrlgsqpshqvpTPSPRPRVFTPQSSPAMPLAPSHPSPYQGPrmqnisdyrasgsqA 873
Cdd:PHA03247  2704 PPPTPEPAPHALVSA--------------------TPLPPGPAAARQASPALPAAPAPPAVPAGP--------------A 2749

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  874 IQPLPLGPGVRPASSQPqllggqrvQAPNPVGFPGTWPLPGslllmacpdITQPGSTSLSETPRLFPLLPLRPPGPSHMV 953
Cdd:PHA03247  2750 TPGGPARPARPPTTAGP--------PAPAPPAAPAAGPPRR---------LTRPAVASLSESRESLPSPWDPADPPAAVL 2812

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  954 SHAPAPPVSflvpYPPGGPVAPCSSVLPTTGILTPHP-GPQDSWKEAPAPGGNLQRnKLPETFMAPAPIT---------- 1022
Cdd:PHA03247  2813 APAAALPPA----ASPAGPLPPPTSAQPTAPPPPPGPpPPSLPLGGSVAPGGDVRR-RPPSRSPAAKPAAparppvrrla 2887

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622966949 1023 APVMSLTPELQGILPLQP--PVSGVSHAPPGAPGELSLQQLQHLPPEKMERKELPP 1076
Cdd:PHA03247  2888 RPAVSRSTESFALPPDQPerPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPL 2943
PHA03247 PHA03247
large tegument protein UL36; Provisional
 823-1053 1.10e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.49  E-value: 1.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  823 PSHQVPTPSPRPRVFTP--QSSPAMPLAPSHPSPYQGPRmqnisDYRASGSQAIQPLPLGPGVRPASSQPQllggQRVQA 900
Cdd:PHA03247  2564 PDRSVPPPRPAPRPSEPavTSRARRPDAPPQSARPRAPV-----DDRGDPRGPAPPSPLPPDTHAPDPPPP----SPSPA 2634

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  901 PNPVGFPGTWPLPGSLLLMACPditQPGSTSLSETPRLFPLLPLRPPGPSHMVSHAPAPPVSFLVPY--PPGGPVAPCSS 978
Cdd:PHA03247  2635 ANEPDPHPPPTVPPPERPRDDP---APGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLadPPPPPPTPEPA 2711

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622966949  979 VLPTTGILTPHPGPQDSWKEAPAPggnlqrnklPETFMAPAPITAPVMSLTPELQGI--LPLQPPVSGVSHAPPGAP 1053
Cdd:PHA03247  2712 PHALVSATPLPPGPAAARQASPAL---------PAAPAPPAVPAGPATPGGPARPARppTTAGPPAPAPPAAPAAGP 2779
PHA03247 PHA03247
large tegument protein UL36; Provisional
 797-1054 2.02e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.71  E-value: 2.02e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  797 PPFPYPRIVVGAIpHSKETSYRLGSQPSH-QVPT--PSPRPRVFTPQSSPAMPLAPSHPSPYQGPRmqniSDYRASGSQA 873
Cdd:PHA03247  2570 PPRPAPRPSEPAV-TSRARRPDAPPQSARpRAPVddRGDPRGPAPPSPLPPDTHAPDPPPPSPSPA----ANEPDPHPPP 2644

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  874 IQPLPLGPGVRPASSQPQLLGGQRVQ--APNPVGFPGTW------PLPGSLLLMACPdiTQPGSTSLSETPRLFPLLPLR 945
Cdd:PHA03247  2645 TVPPPERPRDDPAPGRVSRPRRARRLgrAAQASSPPQRPrrraarPTVGSLTSLADP--PPPPPTPEPAPHALVSATPLP 2722

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  946 PPGPSHMVShAPAPPVSFLVPYPPGGPVAPCSSVLP-----TTGILTPHP------GPQDSWKEAPAPGGNLQRNKLP-- 1012
Cdd:PHA03247  2723 PGPAAARQA-SPALPAAPAPPAVPAGPATPGGPARParpptTAGPPAPAPpaapaaGPPRRLTRPAVASLSESRESLPsp 2801

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1622966949 1013 -ETFMAPAPITAPVMSLTPELQGILPLQPPVSGVSHAPPGAPG 1054
Cdd:PHA03247  2802 wDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG 2844
PHA03247 PHA03247
large tegument protein UL36; Provisional
 734-1098 3.03e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 3.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  734 PHGVSPGPATTYRVTQYANLLAAQGSLATAMSfLPHDCAQPPVqqlrdrlfhAQGSAVLGQQSPPfpyPRIVVGAIPHSK 813
Cdd:PHA03247  2703 PPPPTPEPAPHALVSATPLPPGPAAARQASPA-LPAAPAPPAV---------PAGPATPGGPARP---ARPPTTAGPPAP 2769

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  814 ETSYRLGSQPSHQVPTPSPRPRVFTPQSSPAMPLAPSHPSPYQGPRMQNISDYRASGSQA--IQPLPLGPGVRPASSQPQ 891
Cdd:PHA03247  2770 APPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPppTSAQPTAPPPPPGPPPPS 2849

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  892 L-LGG---------QRVQAPNPVGFPGTWPLPgSLLLMACPDITQPGSTSLSETPRLFPLLPLRPPGPSHMVSHAPAPPV 961
Cdd:PHA03247  2850 LpLGGsvapggdvrRRPPSRSPAAKPAAPARP-PVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQ 2928

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  962 SFLVPYPPGGPVAPCSSVLPTTGILTPHPGPQDSWKEAPAPGG-NLQRNKLPEtfmaPAPITAPVMSLTPELQGIlplqp 1040
Cdd:PHA03247  2929 PQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRvAVPRFRVPQ----PAPSREAPASSTPPLTGH----- 2999

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622966949 1041 PVSGVS--------HAPPgAPGELSLQQLQHLPPEKmerkelppEHQSLKSSFEALLQRCSLSATD 1098
Cdd:PHA03247  3000 SLSRVSswasslalHEET-DPPPVSLKQTLWPPDDT--------EDSDADSLFDSDSERSDLEALD 3056
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 731-1079 9.43e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 50.15  E-value: 9.43e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  731 LRGPHGVSPGPATTYRVTQYANLLAAQGSLATAMSFLPHDCAQPPVQQLRDRLFHA--QGSAVLGQQSPPFPYPRIV-VG 807
Cdd:pfam03154  174 LQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTliQQTPTLHPQRLPSPHPPLQpMT 253

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  808 AIPHSKETSYRLGSQPSHQVPTP-----------------SPRPRVFTPQSSPA-MPLAPSHPSPYQGPRMQNISDYRAS 869
Cdd:pfam03154  254 QPPPPSQVSPQPLPQPSLHGQMPpmphslqtgpshmqhpvPPQPFPLTPQSSQSqVPPGPSPAAPGQSQQRIHTPPSQSQ 333

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  870 GSQAI----QPLPLGPGVRP------ASSQPQLLGGQ------RVQAPNPVGFPGTWPLPGSLLLMAC-----PDITQPG 928
Cdd:pfam03154  334 LQSQQppreQPLPPAPLSMPhikpppTTPIPQLPNPQshkhppHLSGPSPFQMNSNLPPPPALKPLSSlsthhPPSAHPP 413

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  929 STSLSETPRLFPLLPLRPPGPSHMVSHAP----APPVSFLVPYPPGGPVAPCSSVLPTTGILTPHPGPQDSwkeAPAPGG 1004
Cdd:pfam03154  414 PLQLMPQSQQLPPPPAQPPVLTQSQSLPPpaasHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTS---TSSAMP 490

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622966949 1005 NLQrnklpetfmapapitaPVMSLTPELQGILPLQPPVSgvshAPPgapgelslQQLQHLPPEKMERKELPPEHQ 1079
Cdd:pfam03154  491 GIQ----------------PPSSASVSSSGPVPAAVSCP----LPP--------VQIKEEALDEAEEPESPPPPP 537
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 848-1081 2.22e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 49.00  E-value: 2.22e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  848 APSHPSPyqgprMQNISDYRASGSQAI---QPLPLgPGVRPASSQPQLLGGQRVQAPNPVGFPGTWPLPGSlllmACPDI 924
Cdd:pfam03154  145 SPSIPSP-----QDNESDSDSSAQQQIlqtQPPVL-QAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQ----GSPAT 214

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  925 TQPGSTSLSetprlfpllplrppgpshmvshaPAPPVSFLVPYPPGGPVAPCSSVLPTTGILTPHPGPQDSWKEAPAPGG 1004
Cdd:pfam03154  215 SQPPNQTQS-----------------------TAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSL 271

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949 1005 NLQrnklpetfMAPAPitAPVMSLTPELQGILPLQP----PVSGVSHAPPGAPGELS--LQQLQHLPPEKME-RKELPPE 1077
Cdd:pfam03154  272 HGQ--------MPPMP--HSLQTGPSHMQHPVPPQPfpltPQSSQSQVPPGPSPAAPgqSQQRIHTPPSQSQlQSQQPPR 341


                   ....
gi 1622966949 1078 HQSL 1081
Cdd:pfam03154  342 EQPL 345
WD40 COG2319
WD40 repeat [General function prediction only];
13-156 2.82e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.98  E-value: 2.82e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949   13 AWSPASQYplyLATGtsaqqldssfSTNGTLEIFEVDFRDPSLDLKHKGVLSASSRFHkliwgsfgsgllESSGVIAGGG 92
Cdd:COG2319    295 AFSPDGKL---LASG----------SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS------------PDGKTLASGS 349

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622966949   93 DNGMLILYNvthiLSSGKEpvIAQKQKHTGAVRALDFNPfqvlQGNLLASGASDSEVFIWDLNN 156
Cdd:COG2319    350 DDGTVRLWD----LATGEL--LRTLTGHTGAVTSVAFSP----DGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 257-340 4.22e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.94  E-value: 4.22e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  257 PLKVLESHSRGILSVSWSqADAELLLTSAKDSQILCLNLESSEVVYKLPTQSSWCFEVQWCPRDPSVFSaASFDGWISLY 336
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLAS-GSSDKTIRLW 78


                   ....
gi 1622966949  337 SVMG 340
Cdd:cd00200     79 DLET 82
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 120-153 7.73e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 7.73e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1622966949   120 HTGAVRALDFNPfqvlQGNLLASGASDSEVFIWD 153
Cdd:smart00320   11 HTGPVTSVAFSP----DGKYLASGSDDGTIKLWD 40
ACE1-Sec16-like cd09233
Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat ...
 574-694 1.38e-04

Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat complex plays an important role in vesicular traffic of newly synthezised proteins from the endoplasmatic reticulum (ER) to the Golgi apparatus by mediating the formation of transport vesicles. COPII consists of an outer coat, made up of the scaffold proteins Sec31 and Sec13, and the cargo adaptor complex, Sec23 and Sec24, which are recruited by the small GTPase Sar1. Sec16 is involved in the early steps of the assembly process. Sec16 forms elongated heterotetramers with Sec13, Sec13-(Sec16)2-Sec13. It interacts with Sec13 by insertion of a single beta-blade to close the six-bladded beta propeller of Sec13. In the same way Sec13 interacts with Sec31 and Nup145C, a nuclear pore protein, all of these contain a structurally related ancestral coatomer element 1 (ACE1). Sec16 is believed to be a key component in maintaining the integrity of the ER exit site.


Pssm-ID: 187750 [Multi-domain]  Cd Length: 314  Bit Score: 45.33  E-value: 1.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  574 LLLGELGPAVELYLKEERFADAIILAQAGGADLLKQTQERYlAKKKTKISSLLACVVQ---KNWKDVVCTCS-------- 642
Cdd:cd09233     73 LLTGNRKEALELALDNGLWAHALLLASSLGKETWAEVVSRF-ARSESKLNDPLQTLYQlfsGNSPEAITELAdnpaeaew 151

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622966949  643 -LKNWREALALLLTYSSTEKfpelcDM-----LGTRMEQEGgraLTSEARLCYVCSGS 694
Cdd:cd09233    152 aLGNWREHLAIILSNRTSNL-----DLealveLGDLLAQRG---LVEAAHICYLLAGV 201
PTZ00420 PTZ00420
coronin; Provisional
 80-207 2.41e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 45.33  E-value: 2.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949   80 GLLESSGVIA------GGGDNGMLILYNVTHilssgKEPVIAQKqKHTGAVRALDFNPfqvLQGNLLASGASDSEVFIWD 153
Cdd:PTZ00420    33 GIACSSGFVAvpweveGGGLIGAIRLENQMR-----KPPVIKLK-GHTSSILDLQFNP---CFSEILASGSEDLTIRVWE 103

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622966949  154 L--NNLNVPMTLGSKSQYSEPPEDVKALSWNRQAQHILSSAHPSGKAVVWDLrKNE 207
Cdd:PTZ00420   104 IphNDESVKEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDI-ENE 158
WD40 pfam00400
WD domain, G-beta repeat;
120-153 5.44e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 5.44e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1622966949  120 HTGAVRALDFNPfqvlQGNLLASGASDSEVFIWD 153
Cdd:pfam00400   10 HTGSVTSLAFSP----DGKLLASGSDDGTVKVWD 39
PHA03378 PHA03378
EBNA-3B; Provisional
 812-1113 2.23e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 42.36  E-value: 2.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  812 SKETSYRLGSQPSH-QVPTPSPRPRVfTPQSSPAMPLAPSHPSPYQGPRMQNISDYRasgSQAIQPLPLGPGVRPASSQP 890
Cdd:PHA03378   579 SPTTSQLASSAPSYaQTPWPVPHPSQ-TPEPPTTQSHIPETSAPRQWPMPLRPIPMR---PLRMQPITFNVLVFPTPHQP 654

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  891 QllggqrvqAPNPVGFPGTWPLPGSLllMACPDITQPGSTSLSETPRLFPLLPLRPPGPSHMVSHAPA---PPVSFLVPY 967
Cdd:PHA03378   655 P--------QVEITPYKPTWTQIGHI--PYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGraqRPAAATGRA 724

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  968 PPggPVAPCSSVLPTTGILTPHPGPQDSWKEAPAPGGNLQRNKLPE-TFMAPAPITAPVMsltpelqGILPLQPPVSGVS 1046
Cdd:PHA03378   725 RP--PAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAaAPGAPTPQPPPQA-------PPAPQQRPRGAPT 795

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949 1047 HAPP----GAPGELSLQQL--QHLPPEKMERKELPPEHQSLKSS--FEALLQRcsLSATDLVLALGAGVGIH------FF 1112
Cdd:PHA03378   796 PQPPpqagPTSMQLMPRAApgQQGPTKQILRQLLTGGVKRGRPSlkKPAALER--QAAAGPTPSPGSGTSDKivqapvFY 873


                   .
gi 1622966949 1113 P 1113
Cdd:PHA03378   874 P 874
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 795-1054 5.34e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.22  E-value: 5.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  795 QSPPFPyprivvGAIPHSKETSYRLGSQPSHQVPTPS--PRPRVFTPQSSPAMPLAPsHPSPYQGPRMQNISDYRASGSQ 872
Cdd:PRK10263   342 QTPPVA------SVDVPPAQPTVAWQPVPGPQTGEPViaPAPEGYPQQSQYAQPAVQ-YNEPLQQPVQPQQPYYAPAAEQ 414

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  873 AIQPLPLGPGVRPASSQPQLlggqrVQAPNPVGFPGTWPLPGSLLLMACPDITQPGSTslsetprlfpllplrppgpshM 952
Cdd:PRK10263   415 PAQQPYYAPAPEQPAQQPYY-----APAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQT---------------------Y 468

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966949  953 VSHAPAPPvsflvPYPPGGPVAPCSSVLPTTGILTPHPG-PQDSWKEAPAPGGNLQRNKL-------PETFMAPAPITAP 1024
Cdd:PRK10263   469 QQPAAQEP-----LYQQPQPVEQQPVVEPEPVVEETKPArPPLYYFEEVEEKRAREREQLaawyqpiPEPVKEPEPIKSS 543

                          250       260       270
                   ....*....|....*....|....*....|
gi 1622966949 1025 VMSLTPelqgilPLQPPVSGVSHAPPGAPG 1054
Cdd:PRK10263   544 LKAPSV------AAVPPVEAAAAVSPLASG 567
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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