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Conserved domains on  [gi|966963638|ref|XP_015003151|]
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5-hydroxytryptamine receptor 7 isoform X2 [Macaca mulatta]

Protein Classification

5-hydroxytryptamine receptor( domain architecture ID 11607407)

5-hydroxytryptamine (5-HT) receptor is a G-protein coupled receptor (GPCR) for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen; the activity of this receptor is mediated by G proteins that stimulate adenylate cyclase

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
97-395 4.18e-152

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


:

Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 431.31  E-value: 4.18e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGgKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15329   16 VGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSG-YWPFGEILCDVWISFDVLLCTASILNLCAI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVML 256
Cdd:cd15329   95 SVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISIPPLFGWKNKVNDPGVCQVSQDFGYQIYATFGAFYIPLIVML 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 257 FMYYQIYKAArksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisifKREQKAATTLGIIVGAF 336
Cdd:cd15329  175 VLYYKIYRAA-----------------------------------------------------KSERKAIKTLGIIMGAF 201
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966963638 337 TVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15329  202 TLCWLPFFILALLRPFLKPIKCSCIPLWLSRLFLWLGYANSFLNPIIYAKFNREFRTPF 260
 
Name Accession Description Interval E-value
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
97-395 4.18e-152

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 431.31  E-value: 4.18e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGgKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15329   16 VGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSG-YWPFGEILCDVWISFDVLLCTASILNLCAI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVML 256
Cdd:cd15329   95 SVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISIPPLFGWKNKVNDPGVCQVSQDFGYQIYATFGAFYIPLIVML 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 257 FMYYQIYKAArksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisifKREQKAATTLGIIVGAF 336
Cdd:cd15329  175 VLYYKIYRAA-----------------------------------------------------KSERKAIKTLGIIMGAF 201
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966963638 337 TVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15329  202 TLCWLPFFILALLRPFLKPIKCSCIPLWLSRLFLWLGYANSFLNPIIYAKFNREFRTPF 260
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
98-384 8.47e-76

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 236.81  E-value: 8.47e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638   98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPL-FGWAQNVNDDKV--CLISQDF------GYTIYSTAVAF 248
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLlFGWTLTVPEGNVtvCFIDFPEdlskpvSYTLLISVLGF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  249 YIPMSVMLFMYYQIYKAARKSAAKHkfpgfprvepdsvialngivklqkeveecanlsrllkherKNISIFKREQKAATT 328
Cdd:pfam00001 161 LLPLLVILVCYTLIIRTLRKSASKQ----------------------------------------KSSERTQRRRKALKT 200
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638  329 LGIIVGAFTVCWLPFFLLSTARPFICGTSCSC-IPLWVErTFLWLGYANSLINPFIY 384
Cdd:pfam00001 201 LAVVVVVFILCWLPYHIVNLLDSLALDCELSRlLDKALS-VTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
101-405 8.99e-12

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 65.96  E-value: 8.99e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 101 LVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR 180
Cdd:PHA03087  59 IIVIYVLTKTKIKTPMDIYLLNLAVSDL-LFVMTLPF-QIYYYILFQWSFGEFACKIVSGLYYIGFYNSMNFITVMSVDR 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 181 YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGW-AQNVNDDKVCLISQDFGYTIYSTAVAF-------YIPM 252
Cdd:PHA03087 137 YIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYtTKKDHETLICCMFYNNKTMNWKLFINFeiniigmLIPL 216
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 253 SVMLFMYYQIYkaarksaakhkfpgfprvepdsvIALngivklqkeveecanlsrllkherKNISIFKREQKAATTLGII 332
Cdd:PHA03087 217 TILLYCYSKIL-----------------------ITL------------------------KGINKSKKNKKAIKLVLII 249
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966963638 333 VGAFTVCWLPF---FLLSTARPFICGTSC---SCIPLWVERTFLwLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRN 405
Cdd:PHA03087 250 VILFVIFWLPFnvsVFVYSLHILHFKSGCkavKYIQYALHVTEI-ISLSHCCINPLIYAFVSEFFNKHKKKSLKLMFTS 327
 
Name Accession Description Interval E-value
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
97-395 4.18e-152

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 431.31  E-value: 4.18e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGgKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15329   16 VGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSG-YWPFGEILCDVWISFDVLLCTASILNLCAI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVML 256
Cdd:cd15329   95 SVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISIPPLFGWKNKVNDPGVCQVSQDFGYQIYATFGAFYIPLIVML 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 257 FMYYQIYKAArksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisifKREQKAATTLGIIVGAF 336
Cdd:cd15329  175 VLYYKIYRAA-----------------------------------------------------KSERKAIKTLGIIMGAF 201
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966963638 337 TVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15329  202 TLCWLPFFILALLRPFLKPIKCSCIPLWLSRLFLWLGYANSFLNPIIYAKFNREFRTPF 260
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
97-395 1.98e-118

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 345.85  E-value: 1.98e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGgKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15064   16 LGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTG-RWILGQVLCDIWISLDVTCCTASILHLCVI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQN-VNDDKVCLISQDFGYTIYSTAVAFYIPMSVM 255
Cdd:cd15064   95 ALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGWRTPdSEDPSECLISQDIGYTIFSTFGAFYIPLLLM 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 256 LFMYYQIYKAArksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisifKREQKAATTLGIIVGA 335
Cdd:cd15064  175 LILYWKIYRAA-----------------------------------------------------ARERKAAKTLGIILGA 201
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 336 FTVCWLPFFLLSTARPFICgtsCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15064  202 FIVCWLPFFLVALIVPLCS---HCWIPLALKSFFLWLGYFNSLINPLIYTFFNKDFRKAF 258
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
98-395 3.57e-91

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 276.37  E-value: 3.57e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd14967   16 GNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPF-SAVYTLLGYWPFGPVLCRFWIALDVLCCTASILNLCAIS 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGW---AQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSV 254
Cdd:cd14967   95 LDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWrdeTQPSVVDCECEFTPNKIYVLVSSVISFFIPLLI 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 255 MLFMYYQIYKAARksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisifkREQKAATTLGIIVG 334
Cdd:cd14967  175 MIVLYARIFRVAR-----------------------------------------------------RELKAAKTLAIIVG 201
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966963638 335 AFTVCWLPFFLLSTARPFIcgtSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd14967  202 AFLLCWLPFFIIYLVSAFC---PPDCVPPILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
97-392 1.65e-80

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 249.20  E-value: 1.65e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15067   15 AGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGGYWLFGRDWCDVWHSFDVLASTASILNLCVI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWaQNVND----DKVCLISQDFGYTIYSTAVAFYIPM 252
Cdd:cd15067   95 SLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFPAIAWW-RAVDPgpspPNQCLFTDDSGYLIFSSCVSFYIPL 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 253 SVMLFMYYQIYKAARKsaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisifkrEQKAATTLGII 332
Cdd:cd15067  174 VVMLFTYYRIYRAAAK-----------------------------------------------------EQKAAKTLGIV 200
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 333 VGAFTVCWLPFFLLSTARPFiCGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15067  201 MGVFILCWLPFFVTNILIGF-CPSNCVSNPDILFPLVTWLGYINSGMNPIIYACSSRDFR 259
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
97-392 3.10e-79

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 247.26  E-value: 3.10e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGgKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15065   15 FGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLG-YWLFGETFCNIWISFDVMCSTASILNLCAI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASIT-LPPLFGWA-----------QNVNDDKVCLISQDFGYTIYST 244
Cdd:cd15065   94 SLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISfLPIHLGWHrlsqdeikglnHASNPKPSCALDLNPTYAVVSS 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 245 AVAFYIPMSVMLFMYYQIYKAARK---SAAKHKFPGFPRVEPdsvialngivklqkeveecANLSRLLKHERKNISifkr 321
Cdd:cd15065  174 LISFYIPCLVMLLIYSRLYLYARKhvvNIKSQKLPSESGSKF-------------------QVPSLSSKHNNQGVS---- 230
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966963638 322 EQKAATTLGIIVGAFTVCWLPFFLLSTARPFiCGTscsCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15065  231 DHKAAVTLGIIMGVFLICWLPFFIINIIAAF-CKT---CIPPKCFKILTWLGYFNSCLNPIIYSIFNSEFR 297
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
98-392 8.16e-79

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 244.96  E-value: 8.16e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPfVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15331   17 GNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMP-LSAVYEVSQHWFLGPEVCDMWISMDVLCCTASILHLVAIA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRpLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQN-----VNDDKVCLISQDFGYTIYSTAVAFYIPM 252
Cdd:cd15331   96 LDRYWAVTN-IDYIRRRTAKRILIMIAVVWFVSLIISIAPLFGWKDEddldrVLKTGVCLISQDYGYTIFSTVGAFYVPL 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 253 SVMLFMYYQIYKAArksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisifKREQKAATTLGII 332
Cdd:cd15331  175 LLMIIIYWKIYQAA-----------------------------------------------------KRERKAARTLAII 201
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 333 VGAFTVCWLPFFLLSTARPFiCGtsCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15331  202 TGAFVVCWLPFFLVALVMPF-CG--AWQISRFLESFFLWLGYFNSLLNPIIYTIFSPDFR 258
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
98-395 6.48e-77

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 239.97  E-value: 6.48e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPF-VSVTdlIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15066   16 GNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFnASVE--ITGRWMFGYFMCDVWNSLDVYFSTASILHLCCI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLF-GW-------AQNVNDDKVCLISQDFGYTIYSTAVAF 248
Cdd:cd15066   94 SVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISFLPIFlGWytteehlQYRKTHPDQCEFVVNKIYALISSSVSF 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 249 YIPMSVMLFMYYQIYKAArksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisifKREQKAATT 328
Cdd:cd15066  174 WIPCIVMIFTYYRIYLEA-----------------------------------------------------KREHKAAKT 200
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 329 LGIIVGAFTVCWLPFFLLSTARPfICGTSCSCIPLWVERTFlWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15066  201 LGIIMGAFILCWLPFFLWYVTTT-LCGDACPYPPILVSILF-WIGYFNSTLNPLIYAYFNRDFREAF 265
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
98-384 8.47e-76

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 236.81  E-value: 8.47e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638   98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPL-FGWAQNVNDDKV--CLISQDF------GYTIYSTAVAF 248
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLlFGWTLTVPEGNVtvCFIDFPEdlskpvSYTLLISVLGF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  249 YIPMSVMLFMYYQIYKAARKSAAKHkfpgfprvepdsvialngivklqkeveecanlsrllkherKNISIFKREQKAATT 328
Cdd:pfam00001 161 LLPLLVILVCYTLIIRTLRKSASKQ----------------------------------------KSSERTQRRRKALKT 200
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638  329 LGIIVGAFTVCWLPFFLLSTARPFICGTSCSC-IPLWVErTFLWLGYANSLINPFIY 384
Cdd:pfam00001 201 LAVVVVVFILCWLPYHIVNLLDSLALDCELSRlLDKALS-VTLWLAYVNSCLNPIIY 256
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
97-392 1.88e-74

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 233.78  E-value: 1.88e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15053   16 FGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNGGKWYLGPILCDIYIAMDVMCSTASIFNLCAI 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGwAQNV--NDDKVCLISqDFGYTIYSTAVAFYIPMSV 254
Cdd:cd15053   96 SIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLFG-LNNVpyRDPEECRFY-NPDFIIYSSISSFYIPCIV 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 255 MLFMYYQIYKAarksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisiFKREQKAATTLGIIVG 334
Cdd:cd15053  174 MLLLYYRIFRA-----------------------------------------------------LRREKKATKTLAIVLG 200
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966963638 335 AFTVCWLPFF---LLSTARPFICGTSCsCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15053  201 VFLFCWLPFFtlnILNAICPKLQNQSC-HVGPALFSLTTWLGYVNSFLNPIIYTIFNIEFR 260
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
82-395 5.23e-74

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 233.38  E-value: 5.23e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  82 VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGgKWIFGHFFCNVFIAM 161
Cdd:cd15051    1 IVLGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRG-EWPLGPVFCNIYISL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 162 DVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASIT-LPPLFGW------AQNVNDDKVCLIS 234
Cdd:cd15051   80 DVMLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSfLPIHLGWntpdgrVQNGDTPNQCRFE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 235 QDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKhkfpgfprvepdsvialngIVKLQKEVeeCANlsrllkheRK 314
Cdd:cd15051  160 LNPPYVLLVAIGTFYLPLLIMCGVYLRIFRIAREQAKR-------------------INALTPAS--TAN--------SS 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 315 NISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFicgtsCSC-IPLWVERTFLWLGYANSLINPFIYAFFNRDLRT 393
Cdd:cd15051  211 KSAATAREHKATVTLAAVLGAFIICWFPYFTYFTYRGL-----CGDnINETALSVVLWLGYANSALNPILYAFLNRDFRR 285

                 ..
gi 966963638 394 TY 395
Cdd:cd15051  286 AF 287
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
82-392 1.03e-73

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 233.09  E-value: 1.03e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  82 VVIGSILTLITLLTIAGNCLVVISV-CFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDlIGGKWIFGHFfCNVFIA 160
Cdd:cd15057    1 IITGCILYLLVLLTLLGNALVIAAVlRFRHLRSKVTNYFIVSLAVSDLLVAILVMPWAAVNE-VAGYWPFGSF-CDVWVS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 161 MDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASIT-LPPLFGW--AQNVNDDKVCLISQDF 237
Cdd:cd15057   79 FDIMCSTASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISfIPVQLGWhrADDTSEALALYADPCQ 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 238 -------GYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKhkfpgfprvepdsvialngIVKLQKEVEECANLSRLLK 310
Cdd:cd15057  159 cdsslnrTYAISSSLISFYIPVAIMIVTYTRIYRIARRQIRR-------------------IAALERAAQESTNPDSSLR 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 311 herkniSIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFiCG---TSCSCIPLWVERTFLWLGYANSLINPFIYAfF 387
Cdd:cd15057  220 ------SSLRRETKALKTLSIIMGVFVCCWLPFFILNCVLPF-CDlrtAQFPCVPDTTFIVFVWLGWANSSLNPIIYA-F 291

                 ....*
gi 966963638 388 NRDLR 392
Cdd:cd15057  292 NADFR 296
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
98-392 2.30e-73

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 230.71  E-value: 2.30e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15061   16 GNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPL-AIIRQLLGYWPLGSHLCDFWISLDVLLCTASILNLCCIS 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKV-CLISQDFGYTIYSTAVAFYIPMSVML 256
Cdd:cd15061   95 LDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVGPSWHGRRGLGsCYYTYDKGYRIYSSMGSFFLPLLLML 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 257 FMYYQIYKaarksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisIFKREQKAATTLGIIVGAF 336
Cdd:cd15061  175 FVYLRIFR-----------------------------------------------------VIAKERKTAKTLAIVVGCF 201
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 337 TVCWLPFFLLSTARPFicgtsCSCIPLWVERT-FLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15061  202 IVCWLPFFIMYLIEPF-----CDCQFSEALSTaFTWLGYFNSVINPFIYAFYNKDFR 253
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
98-395 6.55e-73

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 229.63  E-value: 6.55e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGgKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15060   17 GNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLG-KWLFGIHLCQMWLTCDILCCTASILNLCAIA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGW---AQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSV 254
Cdd:cd15060   96 LDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLIGWndwPENFTETTPCTLTEEKGYVIYSSSGSFFIPLLI 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 255 MLFMYYQIYKAARKsaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisifkrEQKAATTLGIIVG 334
Cdd:cd15060  176 MTIVYVKIFIATSK-----------------------------------------------------ERRAARTLGIIMG 202
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966963638 335 AFTVCWLPFFLLSTARPFiCgTSCsCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15060  203 VFVVCWLPFFLMYVILPF-C-ETC-SPSAKVVNFITWLGYVNSALNPVIYTIFNLDFRRAF 260
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
97-392 2.09e-72

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 228.38  E-value: 2.09e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGgKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15059   16 VGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMG-YWYFGSVWCEIWLALDVLFCTASIVNLCAI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDD---KVCLISQDFGYTIYSTAVAFYIPMS 253
Cdd:cd15059   95 SLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPPLFGWKDEQPWHgaePQCELSDDPGYVLFSSIGSFYIPLL 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 254 VMLFMYYQIYKAARksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisifKREQKAATTLGIIV 333
Cdd:cd15059  175 IMIIVYARIYRAAK----------------------------------------------------RKERRFTLVLGVVM 202
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966963638 334 GAFTVCWLPFFLLSTARPfICGTscSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15059  203 GAFVLCWLPFFFTYPLVV-VCKT--CGVPELLFKFFFWLGYCNSALNPVIYTIFNKDFR 258
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
98-388 1.48e-69

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 221.39  E-value: 1.48e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd00637   15 GNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPF-SLVSLLLGRWWFGDALCKLLGFLQSVSLLASILTLTAIS 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDF------GYTIYSTAVAFYIP 251
Cdd:cd00637   94 VDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPdltlskAYTIFLFVLLFLLP 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 252 MSVMLFMYYQIYKAARKSAAKHkfpgfprvepdsvialngivklqkeveecanlsRLLKHERKNISIFKREQKAATTLGI 331
Cdd:cd00637  174 LLVIIVCYVRIFRKLRRHRRRI---------------------------------RSSSSNSSRRRRRRRERKVTKTLLI 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 332 IVGAFTVCWLPFFLLSTARPFicGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFN 388
Cdd:cd00637  221 VVVVFLLCWLPYFILLLLDVF--GPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
97-395 5.03e-68

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 217.07  E-value: 5.03e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15326   16 VGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPF-SATLEILGYWVFGRIFCDIWAAVDVLCCTASILSLCAI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNV-NDDKVCLISQDFGYTIYSTAVAFYIPMSVM 255
Cdd:cd15326   95 SIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIGPLLGWKEPApPDDKVCEITEEPFYALFSSLGSFYIPLIVI 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 256 LFMYYQIYKAARKsaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisiFKREQKAATTLGIIVGA 335
Cdd:cd15326  175 LVMYCRVYIVALK--------------------------------------------------FSREKKAAKTLGIVVGM 204
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 336 FTVCWLPFFllsTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15326  205 FILCWLPFF---IALPLGSLFSHLKPPETLFKIIFWLGYFNSCLNPIIYPCSSKEFKRAF 261
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
98-395 1.01e-67

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 216.38  E-value: 1.01e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGgKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15330   17 GNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLN-KWTLGQVTCDLFIALDVLCCTSSILHLCAIA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGW--AQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVM 255
Cdd:cd15330   96 LDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPMLGWrtPEDRSDPDACTISKDPGYTIYSTFGAFYIPLILM 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 256 LFMYYQIYKAArksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisifKREQKAATTLGIIVGA 335
Cdd:cd15330  176 LVLYGRIFKAA-----------------------------------------------------ARERKTVKTLGIIMGT 202
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 336 FTVCWLPFFLLSTARPFiCGTSCScIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15330  203 FILCWLPFFIVALVLPF-CESTCH-MPELLGAIINWLGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
97-392 5.41e-67

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 214.67  E-value: 5.41e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15063   16 LGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPF-SAVNEVLDVWIFGHTWCQIWLAVDVWMCTASILNLCAI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGW------AQNVNDDK----VCLISQDFGYTIYSTAV 246
Cdd:cd15063   95 SLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVGWndgkdgIMDYSGSSslpcTCELTNGRGYVIYSALG 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 247 AFYIPMSVMLFMYYQIYKAARksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisifkREQKAA 326
Cdd:cd15063  175 SFYIPMLVMLFFYFRIYRAAR-----------------------------------------------------METKAA 201
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966963638 327 TTLGIIVGAFTVCWLPFFLLSTARPFicgtSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15063  202 KTVAIIVGCFIFCWLPFFTVYLVRAF----CEDCIPPLLFSVFFWLGYCNSALNPCIYALFSRDFR 263
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
97-389 1.88e-64

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 208.56  E-value: 1.88e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15055   16 LGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMPF-SMIRSIETCWYFGDTFCKLHSSLDYILTSASIFNLVLI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLF------GWAQNVNDDKVCLISQDFGYTIYSTAVAFYI 250
Cdd:cd15055   95 AIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSVLLYdnlnqpGLIRYNSCYGECVVVVNFIWGVVDLVLTFIL 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 251 PMSVMLFMYYQIYKAARKSAAkhkfpgfprvepdsviALNGIVKLQKeveecanlsrllKHERKNISIFKREQKAATTLG 330
Cdd:cd15055  175 PCTVMIVLYMRIFVVARSQAR----------------AIRSHTAQVS------------LEGSSKKVSKKSERKAAKTLG 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966963638 331 IIVGAFTVCWLPFFLLSTARPFIcgtscsCIPLWVERTFLWLGYANSLINPFIYAFFNR 389
Cdd:cd15055  227 IVVGVFLLCWLPYYIVSLVDPYI------STPSSVFDVLIWLGYFNSCLNPLIYALFYP 279
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
99-396 2.00e-64

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 207.88  E-value: 2.00e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISI 178
Cdd:cd15334   18 NSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPF-SIMYIVKETWIMGQVVCDIWLSVDITCCTCSILHLSAIAL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 179 DRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQD-FGYTIYSTAVAFYIPMSVMLF 257
Cdd:cd15334   97 DRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLFWRHQTTSREDECIIKHDhIVFTIYSTFGAFYIPLALILI 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 258 MYYQIYKAArksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisifKREQKAATTLGIIVGAFT 337
Cdd:cd15334  177 LYYKIYRAA-----------------------------------------------------TRERKAATTLGLILGAFV 203
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 338 VCWLPFFLlstaRPFICGTSCSCIPLWVERTFL-WLGYANSLINPFIYAFFNRDLRTTYR 396
Cdd:cd15334  204 ICWLPFFV----KEVIVNTCDSCYISEEMSNFLtWLGYINSLINPLIYTIFNEDFKKAFQ 259
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
99-395 2.53e-64

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 207.47  E-value: 2.53e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPfVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISI 178
Cdd:cd15335   18 NSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMP-LSITYIVMDTWTLGYFICEIWLSVDMTCCTCSILHLCVIAL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 179 DRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFgWAQ--NVNDDKVCLISQD-FGYTIYSTAVAFYIPMSVM 255
Cdd:cd15335   97 DRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIPPLF-WRNhhDANIPSQCIIQHDhVIYTIYSTFGAFYIPLTLI 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 256 LFMYYQIYKAArksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisifKREQKAATTLGIIVGA 335
Cdd:cd15335  176 LILYYRIYHAA-----------------------------------------------------SRERKAARILGLILGA 202
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 336 FTVCWLPFFLlstaRPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15335  203 FILSWLPFFI----KELIVGLSVMTVSPEVADFLTWLGYVNSLVNPLLYTSFNEDFKLAF 258
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
82-395 3.16e-64

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 208.50  E-value: 3.16e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  82 VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAM 161
Cdd:cd15056    1 VVLSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPF-GAIELVNNRWIYGETFCLVRTSL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 162 DVMCCTASIMTLCVISIDRYLGITR-PLTYpvRQNGKCMAKMILSVWLLSASIT-LPPLFGW-----------AQNVNDD 228
Cdd:cd15056   80 DVLLTTASIMHLCCIALDRYYAICCqPLVY--KMTPLRVAVMLGGCWVIPTFISfLPIMQGWnhigiedliafNCASGST 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 229 kVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKhkfpgfprvepdsvialngIVKLQKEVeecanlSRL 308
Cdd:cd15056  158 -SCVFMVNKPFAIICSTVAFYIPALLMVLAYYRIYVAAREQAHQ-------------------IRSLQRAG------SSN 211
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 309 LKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSciPLWveRTFLWLGYANSLINPFIYAFFN 388
Cdd:cd15056  212 HEADQHRNSRMRTETKAAKTLGIIMGCFCVCWAPFFVTNIVDPFIGYRVPY--LLW--TAFLWLGYINSGLNPFLYAFFN 287

                 ....*..
gi 966963638 389 RDLRTTY 395
Cdd:cd15056  288 KSFRRAF 294
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
99-395 1.22e-62

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 203.10  E-value: 1.22e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPfVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISI 178
Cdd:cd15333   22 NAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMP-ISIVYTVTGTWTLGQVVCDIWLSSDITCCTASILHLCVIAL 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 179 DRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFgWAQNVNDD--KVCLISQD-FGYTIYSTAVAFYIPMSVM 255
Cdd:cd15333  101 DRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFF-WRQAKAEEevSECVVNTDhILYTVYSTVGAFYIPTLLL 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 256 LFMYYQIYKAARksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisifKREQKAATTLGIIVGA 335
Cdd:cd15333  180 IALYGRIYVEAR----------------------------------------------------ARERKATKTLGIILGA 207
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 336 FTVCWLPFFLLSTARPfICGTSCSCIPLWVErTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15333  208 FIVCWLPFFIISLVLP-ICKDACWFHLAIFD-FFTWLGYLNSLINPIIYTMSNEDFKQAF 265
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
97-395 1.70e-62

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 202.72  E-value: 1.70e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15062   16 GGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPF-SATLEVLGYWAFGRIFCDVWAAVDVLCCTASIMSLCVI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNV-NDDKVCLISQDFGYTIYSTAVAFYIPMSVM 255
Cdd:cd15062   95 SVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIGPLLGWKEPApADEQACGVNEEPGYVLFSSLGSFYLPLAII 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 256 LFMYYQIYKAARKsaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisiFKREQKAATTLGIIVGA 335
Cdd:cd15062  175 LVMYCRVYVVAFK--------------------------------------------------FSREKKAAKTLGIVVGA 204
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 336 FTVCWLPFFLlstARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15062  205 FVLCWFPFFV---VLPLGSLFSTLKPPEPVFKVVFWLGYFNSCLNPIIYPCSSREFKRAF 261
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
97-384 6.31e-62

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 202.68  E-value: 6.31e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSvTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15058   16 VGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGA-TIVVTGKWQLGNFWCELWTSVDVLCVTASIETLCVI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASIT-LPPLFGW-------AQNVNDDKVCLisqDF----GYTIYST 244
Cdd:cd15058   95 AVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSfVPIMNQWwrandpeANDCYQDPTCC---DFrtnmAYAIASS 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 245 AVAFYIPMSVMLFMYYQIYKAARKSAAKhkfpgfprVEPDSVIALNGIVKLQKEVEECANLSRLlkheRKNISIFKREQK 324
Cdd:cd15058  172 VVSFYIPLLIMIFVYARVFLIATRQLQL--------IDKRRLRFQSECPAPQTTSPEGKRSSGR----RPSRLTVVKEHK 239
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 325 AATTLGIIVGAFTVCWLPFFLLSTARPFicgtSCSCIPLWVERTFLWLGYANSLINPFIY 384
Cdd:cd15058  240 ALKTLGIIMGTFTLCWLPFFIANIINVF----NRNLPPGEVFLLLNWLGYINSGLNPIIY 295
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
99-395 7.15e-62

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 200.95  E-value: 7.15e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISI 178
Cdd:cd15328   18 NLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRSLCQVWISFDVLCCTASIWNVTAIAL 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 179 DRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPL-FGWAQNVNDD-KVCLISQDFGYTIYSTAVAFYIPMSVML 256
Cdd:cd15328   98 DRYWSITRHLEYTLRTRRRISNVMIALTWALSAVISLAPLlFGWGETYSEDsEECQVSQEPSYTVFSTFGAFYLPLCVVL 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 257 FMYYQIYKAARKsaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisifkrEQKAATTLGIIVGAF 336
Cdd:cd15328  178 FVYWKIYKAAQK-----------------------------------------------------EKRAALMVGILIGVF 204
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966963638 337 TVCWLPFFLLSTARPfICgtSCSCIPLWvERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15328  205 VLCWIPFFLTELISP-LC--SCDIPPIW-KSIFLWLGYSNSFFNPLIYTAFNKNYNNAF 259
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
98-394 1.02e-61

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 201.32  E-value: 1.02e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15314   17 GNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPP-SMVRSVETCWYFGDLFCKIHSSFDITLCTASILNLCFIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSA----SITLPPL---FGWAQNVNDDKVCLISQDFGYTIYSTAVAFYI 250
Cdd:cd15314   96 IDRYYAVCQPLLYRSKITVRVVLVMILISWSVSAlvgfGIIFLELnikGIYYNHVACEGGCLVFFSKVSSVVGSVFSFYI 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 251 PMSVMLFMYYQIYKAARKSAakhkfpgfprvepdsvialngivklqkeveecanlsRLLKHERKN--ISIFKREQKAATT 328
Cdd:cd15314  176 PAVIMLCIYLKIFLVAQRQA------------------------------------RSIQSARTKsgASSSKMERKATKT 219
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966963638 329 LGIIVGAFTVCWLPFFLLSTARPFIcgtSCScIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTT 394
Cdd:cd15314  220 LAIVMGVFLLCWTPFFLCNIIDPFI---NYS-IPPVLIEVLNWLGYSNSTLNPFIYAFFYSWFRKA 281
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
98-395 1.74e-60

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 197.42  E-value: 1.74e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15325   17 GNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPF-SAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMSLCIIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNV-NDDKVCLISQDFGYTIYSTAVAFYIPMSVML 256
Cdd:cd15325   96 IDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGPLFGWKEPApEDETICQITEEPGYALFSALGSFYLPLAIIL 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 257 FMYYQIYKAARKsaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisiFKREQKAATTLGIIVGAF 336
Cdd:cd15325  176 VMYCRVYVVALK--------------------------------------------------FSREKKAAKTLGIVVGCF 205
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966963638 337 TVCWLPFFLLSTARPFICGTSCSCIplwVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15325  206 VLCWLPFFLVMPIGSIFPAYKPSDT---VFKITFWLGYFNSCINPIIYPCSSQEFKKAF 261
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
97-395 8.31e-60

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 195.61  E-value: 8.31e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15052   16 GGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTELFGGVWPLPLVLCLLWVTLDVLFCTASIMHLCTI 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPvRQNGKCMAKM-ILSVWLLSASITLP-PLFGW--AQNVNDDKVCLISQDFgYTIYSTAVAFYIPM 252
Cdd:cd15052   96 SLDRYMAIRYPLRTR-RNKSRTTVFLkIAIVWLISIGISSPiPVLGIidTTNVLNNGTCVLFNPN-FVIYGSIVAFFIPL 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 253 SVMLFMYYqiykaarksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherKNISIFKREQKAATTLGII 332
Cdd:cd15052  174 LIMVVTYA-----------------------------------------------------LTIRLLSNEQKASKVLGIV 200
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966963638 333 VGAFTVCWLPFFLLSTARPFicGTSCSC-IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15052  201 FAVFVICWCPFFITNILTGL--CEECNCrISPWLLSVFVWLGYVSSTINPIIYTIFNKTFRRAF 262
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
97-395 1.14e-57

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 190.12  E-value: 1.14e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGkWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15327   16 VGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGF-WAFGRVFCDIWAAVDVLCCTASILSLCVI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNV-NDDKVCLISQDFGYTIYSTAVAFYIPMSVM 255
Cdd:cd15327   95 SVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGPLLGWKEPPpPDESICSITEEPGYALFSSLFSFYLPLMVI 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 256 LFMYYQIYKAARKsaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisiFKREQKAATTLGIIVGA 335
Cdd:cd15327  175 LVMYFRVYVVALK--------------------------------------------------FSREKKAAKTLAIVVGV 204
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 336 FTVCWLPFFLLSTARPFICGTSCSCIplwVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15327  205 FILCWFPFFFVLPLGSFFPALKPSEM---VFKVIFWLGYFNSCVNPIIYPCSSKEFKRAF 261
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
98-395 7.84e-57

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 187.87  E-value: 7.84e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15310   17 GNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAIS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTY---PVRQNGKCMAKMILSVWLLSASITLPPLFGWaQNVNDDKVCLISQDfGYTIYSTAVAFYIPMSV 254
Cdd:cd15310   97 IDRYTAVVMPVHYqhgTGQSSCRRVSLMITAVWVLAFAVSCPLLFGF-NTTGDPTVCSISNP-DFVIYSSVVSFYLPFGV 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 255 MLFMYYQIYkaarksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherkniSIFKREQKAATTLGIIVG 334
Cdd:cd15310  175 TLLVYVRIY-----------------------------------------------------VVLLREKKATQMLAIVLG 201
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966963638 335 AFTVCWLPFFLLStarpfICGTSC-SC-IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15310  202 AFIVCWLPFFLTH-----ILNTHCqAChVPPELYSATTWLGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
98-395 1.19e-54

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 184.44  E-value: 1.19e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLR-QPSNYLIVSLALADLSVAVAVMPFVSVTDlIGGKWIFGHFfCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15320   18 GNTLVCAAVIRFRHLRsKVTNFFVISLAVSDLLVAVLVMPWKAVAE-IAGFWPFGSF-CNIWVAFDIMCSTASILNLCVI 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPL-FGWAQ-------NVNDDKV------CLISQDFGYTIY 242
Cdd:cd15320   96 SVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISFIPVqLNWHKakptsflDLNASLRdltmdnCDSSLNRTYAIS 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 243 STAVAFYIPMSVMLFMYYQIYKAARKSAakHKFPGFPRVEPDSVIALNgiVKLQKEVEECANLSRLLKHErknisiFKRE 322
Cdd:cd15320  176 SSLISFYIPVAIMIVTYTRIYRIAQKQI--RRISALERAAVHAKNCQN--STGNRGSGDCQQPESSFKMS------FKRE 245
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966963638 323 QKAATTLGIIVGAFTVCWLPFFLLSTARPFiCGTSCS---CIPLWVERTFLWLGYANSLINPFIYAfFNRDLRTTY 395
Cdd:cd15320  246 TKVLKTLSVIMGVFVCCWLPFFILNCMVPF-CKPTSTepfCISSTTFDVFVWFGWANSSLNPIIYA-FNADFRKAF 319
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
98-395 6.51e-54

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 180.52  E-value: 6.51e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGgKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15323   17 GNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMG-YWYFGQVWCNIYLALDVLFCTSSIVHLCAIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDK--VCLISQDFGYTIYSTAVAFYIPMSVM 255
Cdd:cd15323   96 LDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLISMYRDPEGDVypQCKLNDETWYILSSCIGSFFAPCLIM 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 256 LFMYYQIYKAARksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisifKREQKAATTLGIIVGA 335
Cdd:cd15323  176 ILVYIRIYRVAK----------------------------------------------------AREKRFTFVLAVVMGV 203
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 336 FTVCWLPFFlLSTARPFICGTSCScIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15323  204 FVVCWFPFF-FSYSLYGICREACE-VPEPLFKFFFWIGYCNSSLNPVIYTIFNQDFRRSF 261
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
97-395 1.86e-53

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 179.05  E-value: 1.86e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTdLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15049   16 GGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVY-LVMGYWPLGPLLCDLWLALDYVASNASVMNLLLI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGW-----AQNVNDDKvCLIS--QDFGYTIYSTAVAFY 249
Cdd:cd15049   95 SFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVLWAPAILGWqyfvgERTVPDGQ-CYIQflDDPAITFGTAIAAFY 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 250 IPMSVMLFMYYQIYKAARksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisifkREQKAATTL 329
Cdd:cd15049  174 LPVLVMTILYWRIYRETA-----------------------------------------------------RERKAARTL 200
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 330 GIIVGAFTVCWLPFFLLstarpFICGTSC-SCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15049  201 SAILLAFIITWTPYNIL-----VLVSTFCaKCIPDTLWSFGYWLCYINSTINPFCYALCNKTFRKTF 262
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
97-384 6.80e-53

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 178.94  E-value: 6.80e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15958   16 AGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPF-GATLVVRGRWLYGSFFCELWTSVDVLCVTASIETLCVI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASIT-LPPLFGWAQN--------VNDDKVCLISQDFGYTIYSTAVA 247
Cdd:cd15958   95 AIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALVSfLPIMMHWWRDeddqalkcYEDPGCCDFVTNRAYAIASSIIS 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 248 FYIPMSVMLFMYYQIYKAARKSAAKhkfpgfprvepdsvialngIVKLQKEVEECANLSRLLKHERKNISIFKREQKAAT 327
Cdd:cd15958  175 FYIPLLIMIFVYLRVYREAKKQIKK-------------------IDKCEGRFHNTLTGLGRKCKRRPSRILALREQKALK 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 328 TLGIIVGAFTVCWLPFFLLSTARPFicgtSCSCIPLWVERTFLWLGYANSLINPFIY 384
Cdd:cd15958  236 TLGIIMGVFTLCWLPFFLVNVVNVF----NRELVPDWLFVFFNWLGYANSAFNPIIY 288
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
98-392 4.82e-51

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 174.03  E-value: 4.82e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGgKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15048   17 GNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTG-KWPFGKVFCKAWLVVDYTLCTASALTIVLIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGW----AQNVNDDKVCLI--SQDFGYTIYSTAVAFYIP 251
Cdd:cd15048   96 LDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLLYGPAIIGWdlwtGYSIVPTGDCEVefFDHFYFTFITSVLEFFIP 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 252 MSVMLFMYYQIYKAARK-SAAKHKfpgfPRVEPDSVIALNGIVKLQKEVEEcanlsrllkherknisiFKREQKAATTLG 330
Cdd:cd15048  176 FISVSFFNLLIYLNIRKrSRRRPL----RSVPILPASQNPSRARSQREQVK-----------------LRRDRKAAKSLA 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966963638 331 IIVGAFTVCWLPFFLLSTARPFiCgtSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15048  235 ILVLVFLICWAPYTILTIIRSF-C--SGSCVDSYLYEFTFWLLWTNSAINPFLYAACHPRFR 293
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
82-395 4.84e-50

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 172.06  E-value: 4.84e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  82 VVIGSILTLITLLTIAGNCLVVISVCFVKKLR-QPSNYLIVSLALADLSVAVAVMPFVSVTDlIGGKWIFGHFfCNVFIA 160
Cdd:cd15319    1 VVTGCLLSLLILWTLLGNILVCAAVVRFRHLRsKVTNIFIVSLAVSDLFVALLVMPWKAVAE-VAGYWPFGAF-CDVWVA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 161 MDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPL-FGWAQNVNDDKVCLISQDFG- 238
Cdd:cd15319   79 FDIMCSTASILNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISFIPVqLNWHKDSGDDWVGLHNSSISr 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 239 -------------YTIYSTAVAFYIPMSVMLFMYYQIYKAARksaakhkfpgfprvepdsvIALNGIVKLQKEVE--ECA 303
Cdd:cd15319  159 qveencdsslnrtYAISSSLISFYIPVAIMIVTYTRIYRIAQ-------------------IQIRRISSLERAAEhaQSC 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 304 NLSRLLKHERKNI-SIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFiCGTSCS-------CIPLWVERTFLWLGYA 375
Cdd:cd15319  220 RSNRIDCHHHTSLrTSIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPF-CDRPPAdpdaglpCVSETTFDVFVWFGWA 298
                        330       340
                 ....*....|....*....|
gi 966963638 376 NSLINPFIYAfFNRDLRTTY 395
Cdd:cd15319  299 NSSLNPIIYA-FNADFRKVF 317
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
98-395 5.62e-50

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 170.49  E-value: 5.62e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGgKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15321   23 GNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMG-YWYFRKTWCEIYLALDVLFCTSSIVHLCAIS 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKV---CLISQDFGYTIYSTAVAFYIPMSV 254
Cdd:cd15321  102 LDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIYKGKQKDEQGGlpqCKLNEEAWYILSSSIGSFFAPCLI 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 255 MLFMYYQIYKAARksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisifKREQKAATTLGIIVG 334
Cdd:cd15321  182 MILVYLRIYLIAK----------------------------------------------------NREKRFTFVLAVVIG 209
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966963638 335 AFTVCWLPFFLLSTARPfICGTSCScIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15321  210 VFVLCWFPFFFSYSLGA-ICPELCK-VPHSLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAF 268
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
97-395 2.55e-49

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 168.48  E-value: 2.55e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15308   16 AGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYVYSEFQGGVWTLSPVLCDALMTMDVMLCTASIFNLCAI 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVML 256
Cdd:cd15308   96 SVDRFIAVSVPLNYNRRQGSVRQLLLISATWILSFAVASPVIFGLNNVPNRDPAVCKLEDNNYVVYSSVCSFFIPCPVML 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 257 FMYYQIYKAarksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisiFKREQKAATTLGIIVGAF 336
Cdd:cd15308  176 VLYCAMFRG-----------------------------------------------------LGRERKAMRVLPVVVGAF 202
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966963638 337 TVCWLPFFLLSTARPfICgTSCScIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15308  203 LFCWTPFFVVHITRA-LC-ESCS-IPPQLISIVTWLGYVNSALNPVIYTVFNAEFRNVF 258
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
97-384 3.18e-49

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 169.32  E-value: 3.18e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPfVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15959   16 GGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVP-PGATILLTGHWPLGTTVCELWTSVDVLCVTASIETLCAI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFG-W--------AQNVNDD-KVCLISQDFGYTIYSTAV 246
Cdd:cd15959   95 AVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFLPIMNqWwrdgadeeAQRCYDNpRCCDFVTNMPYAIVSSTV 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 247 AFYIPMSVMLFMYYQIYKAARKS-----AAKHKFPGFPrvepdsvialngiVKLQKEVEECANL-SRLLKherknisifK 320
Cdd:cd15959  175 SFYVPLLVMIFVYVRVFVVATRQvrlirKDKVRFPPEE-------------SPPAESRPACGRRpSRLLA---------I 232
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 321 REQKAATTLGIIVGAFTVCWLPFFLLSTARPFicgtscsCIPLWVERTFL---WLGYANSLINPFIY 384
Cdd:cd15959  233 KEHKALKTLGIIMGTFTLCWLPFFVANIIKVF-------CRSLVPDPAFLflnWLGYANSAFNPIIY 292
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
98-395 4.99e-49

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 167.81  E-value: 4.99e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15322   17 GNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPF-SLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDK--VCLISQDFGYTIYSTAVAFYIPMSVM 255
Cdd:cd15322   96 LDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKKSGQPEgpICKINDEKWYIISSCIGSFFAPCLIM 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 256 LFMYYQIYKAARksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisifKREQKAATTLGIIVGA 335
Cdd:cd15322  176 VLVYIRIYQIAK----------------------------------------------------NREKRFTFVLAVVIGV 203
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966963638 336 FTVCWLPFFLLSTARPFicgtsCSC-IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15322  204 FVICWFPFFFTYTLTAV-----CDCsVPETLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
98-388 5.00e-49

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 168.69  E-value: 5.00e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15312   17 GNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPY-SMVRSVESCWYFGDLFCKIHSSLDMMLSTTSIFHLCFIA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFgwaQNVNDDKVclisQDFGYTIYST------------- 244
Cdd:cd15312   96 VDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFAFGVVF---SEVNLEGI----EDYVALVSCTgscvlifnklwgv 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 245 ---AVAFYIPMSVMLFMYYQIYKAARKSAAkhkfpgfprvepdsviALNGIVKLQKeveecanlsrllKHERKNISiFKR 321
Cdd:cd15312  169 iasLIAFFIPGTVMIGIYIKIFFVARKHAK----------------VINNRPSVTK------------GDSKNKLS-KKK 219
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 322 EQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTScsciPLWVERTFLWLGYANSLINPFIYAFFN 388
Cdd:cd15312  220 ERKAAKTLSIVMGVFLLCWLPFFVATLIDPFLNFST----PVDLFDALVWLGYFNSTCNPLIYGFFY 282
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
98-395 6.55e-49

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 167.36  E-value: 6.55e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15324   17 GNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPF-SLANEVMGYWYFGSTWCAFYLALDVLFCTSSIVHLCAIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFgwaQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLF 257
Cdd:cd15324   96 LDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLL---MTKHDEWECLLNDETWYILSSCTVSFFAPGLIMIL 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 258 MYYQIYKAARksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisifKREQKAATTLGIIVGAFT 337
Cdd:cd15324  173 VYCKIYRVAK----------------------------------------------------MREKRFTFVLAVVMGVFV 200
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966963638 338 VCWLPFFLLSTARPfICGTSCScIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15324  201 LCWFPFFFTYSLHA-VCRKRCG-IPDALFNLFFWIGYCNSSVNPIIYTIFNRDFRKAF 256
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
97-387 9.87e-49

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 167.62  E-value: 9.87e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTdLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15317   16 SGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIR-TVETCWYFGDLFCKFHTGLDLLLCTTSIFHLCFI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQ-----NVNDDKVC------LISQDFGYTiysTA 245
Cdd:cd15317   95 AIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIYTFGLIYTGANdegleEYSSEISCvggcqlLFNKIWVLL---DF 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 246 VAFYIPMSVMLFMYYQIYKAARKSAakhkfpgfprvepdsvialngivklqKEVEECANLSRLLKHERKNISIfKREQKA 325
Cdd:cd15317  172 LTFFIPCLIMIGLYAKIFLVARRQA--------------------------RKIQNMEDKFRSSEENSSKASA-SRERKA 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966963638 326 ATTLGIIVGAFTVCWLPFFLLSTARPFICGTScsciPLWVERTFLWLGYANSLINPFIYAFF 387
Cdd:cd15317  225 AKTLAIVMGIFLFCWLPYFIDTIVDEYSNFIT----PAIVFDAVIWLGYFNSAFNPFIYAFF 282
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
97-392 2.98e-47

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 163.05  E-value: 2.98e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGgKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15054   16 AGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYG-RWVLARDFCPIWYAFDVMCCSASILNLCVI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPP-------LFGWAQNVN-----DDKVCLISQDFGYTIYST 244
Cdd:cd15054   95 SLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPielgwheLGHERTLPNltsgtVEGQCRLLVSLPYALVAS 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 245 AVAFYIPMSVMLFMYYQIYKAARKSAakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisifkreqK 324
Cdd:cd15054  175 CLTFFLPSGAICFTYCRILLAARKAL-----------------------------------------------------K 201
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966963638 325 AATTLGIIVGAFTVCWLPFFLLSTARPFicgtsCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15054  202 ASLTLGILLGMFFVTWLPFFVANVVQAV-----CDCVSPGLFDVLTWLGYCNSTMNPIIYPLFMRDFK 264
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
98-395 6.42e-47

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 162.21  E-value: 6.42e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPfVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15050   17 LNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMP-LNIVYLLESKWILGRPVCLFWLSMDYVASTASIFSLFILC 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLfGWAQNVNDD-KVCLISQ---DFG----YTIYSTAVAFY 249
Cdd:cd15050   96 IDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVIPIL-GWHHFARGGeRVVLEDKcetDFHdvtwFKVLTAILNFY 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 250 IPMSVMLFMYYQIYKAARksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisifkREQKAATTL 329
Cdd:cd15050  175 IPSLLMLWFYAKIFKAVN-----------------------------------------------------RERKAAKQL 201
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 330 GIIVGAFTVCWLPFFLLstarpFICGTSC-SCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15050  202 GFIMAAFILCWIPYFIL-----FMVIAFCkNCCNENLHMFTIWLGYINSTLNPFIYPLCNENFKKTF 263
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
98-384 9.36e-47

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 163.11  E-value: 9.36e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15957   17 GNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPF-GAAHILLKTWTFGNFWCEFWTSIDVLCVTASIETLCVIA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNgKCMAK-MILSVWLLSASIT-LPPLFGWAQNVN--------DDKVCLISQDFGYTIYSTAVA 247
Cdd:cd15957   96 VDRYFAITSPFKYQSLLT-KNKARvIILMVWIVSGLTSfLPIQMHWYRATHqeaincyaEETCCDFFTNQAYAIASSIVS 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 248 FYIPMSVMLFMYYQIYKAARKSAAKhkfpgfprvepdsVIALNGIVKLQKEVEecaNLSRLLKHERKNISIFKREQKAAT 327
Cdd:cd15957  175 FYVPLVIMVFVYSRVFQEAKRQLQK-------------IDKSEGRFHNQNIDQ---NGSGGGGGNRRRSKFCLKEHKALK 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 328 TLGIIVGAFTVCWLPFFLLSTARPFicgtSCSCIPLWVERTFLWLGYANSLINPFIY 384
Cdd:cd15957  239 TLGIIMGTFTLCWLPFFIVNIVHVI----QDNLIRKEVYILLNWIGYVNSGFNPLIY 291
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
98-395 1.41e-46

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 160.97  E-value: 1.41e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGgKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15309   17 GNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVG-EWRFSRIHCDIFVTLDVMMCTASILNLCAIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGK-CMAKMILSVWLLSASITLPPLFGWaqNVNDDKVCLISQDfGYTIYSTAVAFYIPMSVML 256
Cdd:cd15309   96 IDRYTAVAMPMLYNTRYSSKrRVTVMISVVWVLSFAISCPLLFGL--NNTDQNECIIANP-AFVVYSSIVSFYVPFIVTL 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 257 FMYYQIYkaarksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherkniSIFKREQKAATTLGIIVGAF 336
Cdd:cd15309  173 LVYVQIY-----------------------------------------------------IVLQKEKKATQMLAIVLGVF 199
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 337 TVCWLPFFLLStarpfICGTSCSC-IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15309  200 IICWLPFFITH-----ILNMHCDCnIPPALYSAFTWLGYVNSAVNPIIYTTFNIEFRKAF 254
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
97-402 7.09e-46

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 160.12  E-value: 7.09e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPfVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15307   16 AGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMP-LGILTLVKGHFPLSSEHCLTWICLDVLFCTASIMHLCTI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVND---DKVCLISqDFGYTIYSTAVAFYIPMS 253
Cdd:cd15307   95 SVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKDHASvlvNGTCQIP-DPVYKLVGSIVCFYIPLG 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 254 VMLFMYyqiykaarksaakhkfpgfprvepdsvialngivklqkeveeCANLSRLLKHERKNISIFKREQKAATTLGIIV 333
Cdd:cd15307  174 VMLLTY------------------------------------------CLTVRLLARQRSRHGRIIRLEQKATKVLGVVF 211
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966963638 334 GAFTVCWLPFFLLSTArPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQ 402
Cdd:cd15307  212 FTFVILWSPFFVLNLL-PTVCAECEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCR 279
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
97-397 2.07e-42

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 150.47  E-value: 2.07e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15304   16 AGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAI 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLtYPVRQNGKCMAKM-ILSVWLLSASITLP-PLFGWAQN--VNDDKVCLISQDfGYTIYSTAVAFYIPM 252
Cdd:cd15304   96 SLDRYIAIRNPI-HHSRFNSRTKAFLkIIAVWTISVGISMPiPVFGLQDDskVFKEGSCLLADE-NFVLIGSFVAFFIPL 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 253 SVMLFMYYQIYKAARKSAAKhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisifkrEQKAATTLGII 332
Cdd:cd15304  174 TIMVITYFLTIKSLQQSISN-------------------------------------------------EQKASKVLGIV 204
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966963638 333 VGAFTVCWLPFFlLSTARPFICGTSCSCIPLW-VERTFLWLGYANSLINPFIYAFFNRdlrtTYRS 397
Cdd:cd15304  205 FFLFVVMWCPFF-ITNVMAVICKESCNEVVIGgLLNVFVWIGYLSSAVNPLVYTLFNK----TYRS 265
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
82-395 8.64e-42

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 148.82  E-value: 8.64e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  82 VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGgKWIFGHFFCNVFIAM 161
Cdd:cd15301    1 VLIVIVAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALG-YWPLGYEVCDTWLAI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 162 DVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGW----AQNVNDDKVCLIS--Q 235
Cdd:cd15301   80 DYLASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLLLWPPWIYSWpyieGKRTVPAGTCYIQflE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 236 DFGYTIYSTAV-AFYIPMSVMLFMYYQIYKAARKSaakhkfpgfprvepdsvialngivklQKeveecanlsrllkherk 314
Cdd:cd15301  160 TNPYVTFGTALaAFYVPVTIMCILYWRIWRETKKR--------------------------QK----------------- 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 315 nisifKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFicgTSCS-CIPLWVERTFLWLGYANSLINPFIYAFFNRDLRT 393
Cdd:cd15301  197 -----KQESKAAKTLSAILLAFIVTWTPYNVLVLIKAF---FPCSdTIPTELWDFSYYLCYINSTINPLCYALCNAAFRR 268

                 ..
gi 966963638 394 TY 395
Cdd:cd15301  269 TY 270
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
97-393 3.24e-41

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 148.13  E-value: 3.24e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGkWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd14993   16 VGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRP-WVFGEVLCKAVPYLQGVSVSASVLTLVAI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDD--------KVCL-----ISQDFGYTIYS 243
Cdd:cd14993   95 SIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISsepgtitiYICTedwpsPELRKAYNVAL 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 244 TAVAFYIPMSVMLFMYYQI-YKAARKsaakhKFPGFPRVEPDSvialngivklqkeveecaNLSRLLKHERknisifkre 322
Cdd:cd14993  175 FVVLYVLPLLIISVAYSLIgRRLWRR-----KPPGDRGSANST------------------SSRRILRSKK--------- 222
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966963638 323 qKAATTLGIIVGAFTVCWLPFFLLSTARPFiCGTSCSCIPLWVERTF---LWLGYANSLINPFIYAFFNRDLRT 393
Cdd:cd14993  223 -KVARMLIVVVVLFALSWLPYYVLSILLDF-GPLSSEESDENFLLILpfaQLLGYSNSAINPIIYCFMSKKFRR 294
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
97-395 8.59e-39

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 141.24  E-value: 8.59e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLigGKWIfgHFFCNVFIAMDVMC-CTASIMTLCV 175
Cdd:cd14968   16 LGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILISL--GLPT--NFHGCLFMACLVLVlTQSSIFSLLA 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 176 ISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGW-------AQNVNDDKVCLISQ--DFGYTIYSTAV 246
Cdd:cd14968   92 IAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMFGWnngapleSGCGEGGIQCLFEEviPMDYMVYFNFF 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 247 AF-YIPMSVMLFMYYQIYKAARKsaakhkfpgfprvepdsvialngivKLQKEVEECANlsrllkheRKNISIFKREQKA 325
Cdd:cd14968  172 ACvLVPLLIMLVIYLRIFRVIRK-------------------------QLRQIESLLRS--------RRSRSTLQKEVKA 218
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966963638 326 ATTLGIIVGAFTVCWLPFFLLSTARPFiCGTSCSCIPLwvertFLW---LGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd14968  219 AKSLAIILFLFALCWLPLHIINCITLF-CPECKVPKIL-----TYIailLSHANSAVNPIVYAYRIRKFRQTF 285
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
98-402 1.99e-38

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 140.08  E-value: 1.99e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSvTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15299   20 GNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFT-TYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVIS 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKV----CLIsQDFGYTI--YSTAV-AFYI 250
Cdd:cd15299   99 FDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVppdeCFI-QFLSEPIitFGTAIaAFYL 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 251 PMSVMLFMYYQIYKAARKsaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisifkrEQKAATTLG 330
Cdd:cd15299  178 PVTIMTILYWRIYKETIK-----------------------------------------------------EKKAAQTLS 204
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966963638 331 IIVGAFTVCWLPFFLLSTARPFiCGtscSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQ 402
Cdd:cd15299  205 AILLAFIITWTPYNIMVLVNTF-CD---SCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQ 272
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
98-387 3.04e-38

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 139.99  E-value: 3.04e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDlIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15316   17 GNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRS-VESCWYFGESFCTFHTCCDVSFCYASLFHLCFIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFgwaQNVNDDKV------------CLISQDFGYTIYSTa 245
Cdd:cd15316   96 VDRYIAVTDPLVYPTKFTVSVSGICISVSWIFSLTYSFSVFY---TGVNDDGLeelvnalncvggCQIILNQNWVLVDF- 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 246 VAFYIPMSVMLFMYYQIYKAARKSAAKhkfpgfprvepdsvialngIVKLQKEVEECAnlsrllkhERKNISIFKREQKA 325
Cdd:cd15316  172 LLFFIPTFAMIILYGKIFLVAKQQARK-------------------IEMTSSKAESSS--------ESYKDRVARRERKA 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966963638 326 ATTLGIIVGAFTVCWLPFFLLSTARPFIcgtsCSCIPLWVERTFLWLGYANSLINPFIYAFF 387
Cdd:cd15316  225 AKTLGITVIAFLVSWLPYLIDVLIDAFM----NFITPPYIYEICCWCAYYNSAMNPLIYALF 282
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
98-401 8.16e-38

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 138.50  E-value: 8.16e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15305   17 GNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDYAWPLPRYLCPIWISLDVLFSTASIMHLCAIS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPvRQNGKCMAKM-ILSVWLLSASITLP-PLFGWAqnvNDDKV-----CLISqDFGYTIYSTAVAFYI 250
Cdd:cd15305   97 LDRYVAIRNPIEHS-RFNSRTKAMMkIAAVWTISIGISMPiPVIGLQ---DDEKVfvngtCVLN-DENFVLIGSFVAFFI 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 251 PMSVMLFMYYQIYKAARKSAAkhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisiFKREQKAATTLG 330
Cdd:cd15305  172 PLIIMVITYCLTIQVLQRQQA-----------------------------------------------INNERRASKVLG 204
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966963638 331 IIVGAFTVCWLPFFlLSTARPFICGTSCScIPLWVE--RTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQC 401
Cdd:cd15305  205 IVFFLFLIMWCPFF-ITNILSVLCKEACD-QKLMEEllNVFVWVGYVSSGINPLVYTLFNKTYRRAFSNYIRC 275
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
98-394 8.38e-38

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 138.49  E-value: 8.38e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIgGKWIFGHFFCNVF-IAMDVMCCTaSIMTLCVI 176
Cdd:cd14969   17 LNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLS-GRWSFGDPGCVIYgFAVTFLGLV-SISTLAAL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYpVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNV--NDDKVCLI---SQDFG---YTIYSTAVAF 248
Cdd:cd14969   95 AFERYLVIVRPLKA-FRLSKRRALILIAFIWLYGLFWALPPLFGWSSYVpeGGGTSCSVdwySKDPNslsYIVSLFVFCF 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 249 YIPMSVMLFMYYQIYKAARKSAAKhkfpgfprvepdsvialngivklqkeveecanlSRLLKHERKNISIFKREQKAATT 328
Cdd:cd14969  174 FLPLAIIIFCYYKIYRTLRKMSKR---------------------------------AARRKNSAITKRTKKAEKKVAKM 220
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 329 LGIIVGAFTVCWLPFFLLSTARPFicgTSCSCIPLWVeRTFLWL-GYANSLINPFIYAFFNRDLRTT 394
Cdd:cd14969  221 VLVMIVAFLIAWTPYAVVSLYVSF---GGESTIPPLL-ATIPALfAKSSTIYNPIIYVFMNKQFRRA 283
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
98-401 3.00e-37

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 136.89  E-value: 3.00e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15306   17 GNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAMWPLPLVLCPIWLFLDVLFSTASIMHLCAIS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYP-VRQNGKCMAKMILsVWLLSASITLPPLFGWAQNVNDDK---VCLISQD-FGY-TIYSTAVAFYIP 251
Cdd:cd15306   97 LDRYIAIKKPIQASqYNSRATAFIKITV-VWLISIGIAIPVPIKGIETDVDNPnniTCVLTKErFGDfILFGSLAAFFTP 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 252 MSVMLFMYYQIYKAARKSAakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisiFKREQKAATTLGI 331
Cdd:cd15306  176 LAIMIVTYFLTIHALRKQT------------------------------------------------ITNEQRASKVLGI 207
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 332 IVGAFTVCWLPFFLLSTARpFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQC 401
Cdd:cd15306  208 VFFLFLLMWCPFFITNITS-VLCDSCNQTTLQMLMEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITC 276
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
98-395 1.22e-35

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 132.40  E-value: 1.22e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSvTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd17790   17 GNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYT-TYILMGHWALGTVACDLWLALDYVASNASVMNLLIIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKV----CLIsQDFGYTI--YSTAV-AFYI 250
Cdd:cd17790   96 FDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLWAPAILFWQYLVGERTVlagqCYI-QFLSQPIitFGTAIaAFYL 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 251 PMSVMLFMYYQIYKAARKsaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisifkrEQKAATTLG 330
Cdd:cd17790  175 PVTIMIILYWRIYRETIK-----------------------------------------------------EKKAARTLS 201
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966963638 331 IIVGAFTVCWLPFFLLstarpFICGTSC-SCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd17790  202 AILLAFILTWTPYNIM-----VLVSTFCkDCVPKTLWELGYWLCYVNSTVNPMCYALCNKSFRDTF 262
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
82-395 3.60e-35

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 131.02  E-value: 3.60e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  82 VVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAM 161
Cdd:cd15302    1 ILLALITAILSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMPFYTVYVLNGDYWPLGWVLCDLWLSV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 162 DVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKV-----CLIsQD 236
Cdd:cd15302   81 DYTVCLVSIYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITWIIPALLFFISIFGWQYFTGQGRSlpegeCYV-QF 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 237 FGYTIYSTAVA---FYIPMSVMLFMYYQIYKAArksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkher 313
Cdd:cd15302  160 MTDPYFNMGMYigyYWTTLIVMLILYAGIYRAA----------------------------------------------- 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 314 knisifKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFiCgTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRT 393
Cdd:cd15302  193 ------NRARKALRTITFILGAFVICWTPYHILATIYGF-C-EAPPCVNETLYTISYYLCYMNSPINPFCYALANQQFKK 264

                 ..
gi 966963638 394 TY 395
Cdd:cd15302  265 TF 266
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
97-393 4.69e-35

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 131.34  E-value: 4.69e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQ-PSNYLIVSLALADLSVAVAvMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCV 175
Cdd:cd15104   15 TGNLLVIVALLKLIRKKDtKSNCFLLNLAIADFLVGLA-IPGLATDELLSDGENTQKVLCLLRMCFVITSCAASVLSLAA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 176 ISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPL-FGWAQNVNDDKVCLISQDF--GYTIYSTAVAFYIPM 252
Cdd:cd15104   94 IAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLPLiSPQFQQTSYKGKCSFFAAFhpRVLLVLSCMVFFPAL 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 253 SVMLFMYYQIYKAARKSAAKhkfpgfprvepdsvialngIVKLQKEVEECANLSRLLKHerknisifkreQKAATTLGII 332
Cdd:cd15104  174 LLFVFCYCDILKIARVHSRA-------------------IYKVEHALARQIHPRRTLSD-----------FKAARTVAVL 223
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966963638 333 VGAFTVCWLPFfllstarpFICG----TSCSCIPLWVERTFLW-LGYANSLINPFIYAFFNRDLRT 393
Cdd:cd15104  224 IGCFLLSWLPF--------QITGlvqaLCDECKLYDVLEDYLWlLGLCNSLLNPWIYAFWQKEVRR 281
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
98-395 3.31e-34

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 128.22  E-value: 3.31e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGgKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15300   17 GNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMG-YWALGSLACDLWLALDYVASNASVMNLLVIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKV----CLISQDFGYTI-YSTAV-AFYIP 251
Cdd:cd15300   96 FDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPPILCWQYFVGKRTVpereCQIQFLSEPTItFGTAIaAFYIP 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 252 MSVMLFMYYQIYKAARKsaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisifkrEQKAATTLGI 331
Cdd:cd15300  176 VSVMTILYCRIYKETIK-----------------------------------------------------ERKAAQTLSA 202
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966963638 332 IVGAFTVCWLPFFLLstarpFICGTSCS-CIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15300  203 ILLAFIITWTPYNIM-----VLVSTFCSdCIPLTLWHLGYWLCYVNSTVNPMCYALCNKTFRKTF 262
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
97-395 5.60e-34

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 128.51  E-value: 5.60e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFvSVTDLIGgkwIFGHFFCNVFIAMDVMCCT-ASIMTLCV 175
Cdd:cd15069   16 AGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPF-AITISLG---FCTDFHSCLFLACFVLVLTqSSIFSLLA 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 176 ISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFY----IP 251
Cdd:cd15069   92 VAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGLTPFLGWNKAMSATNNSTNPADHGTNHSCCLISCLfenvVP 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 252 MSVMLFmyyqiykaarksaakhkFPGFPRVEPDSVIALNGIVKLQkeVEECANLSR--LLKHERkniSIFKREQKAATTL 329
Cdd:cd15069  172 MSYMVY-----------------FNFFGCVLPPLLIMLVIYIKIF--LVACRQLQRteLMDHSR---TTLQREIHAAKSL 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966963638 330 GIIVGAFTVCWLPFFLLSTARPFiCGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15069  230 AIIVGIFALCWLPVHILNCITLF-QPEFSKSKPKWAMNVAILLSHANSVVNPIVYAYRNRDFRYTF 294
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
98-395 6.19e-34

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 127.78  E-value: 6.19e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGgKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15297   17 GNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIG-YWPLGPVVCDLWLALDYVVSNASVMNLLIIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVN----DDKVCLIsQDFGYTI--YSTAV-AFYI 250
Cdd:cd15297   96 FDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGgrtvPEGECYI-QFFSNAAvtFGTAIaAFYL 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 251 PMSVMLFMYYQIYKAArksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisifKREQKAATTLG 330
Cdd:cd15297  175 PVIIMTVLYWQISRAS-----------------------------------------------------SREKKVTRTIL 201
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966963638 331 IIVGAFTVCWLPFFLLstarpFICGTSCS-CIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15297  202 AILLAFIITWTPYNVM-----VLINTFCAsCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTF 262
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
98-392 1.17e-33

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 127.72  E-value: 1.17e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIgGKWIFGHFFCN-VFIAMDV-MCCtaSIMTLCV 175
Cdd:cd15203   17 GNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLT-KNWPFGSILCKlVPSLQGVsIFV--STLTLTA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 176 ISIDRYLGITRPLTYPVRQNGKCMakMILSVWLLSASITLPplFGWAQNVNDDKVCLISQDFGY-----------TIYST 244
Cdd:cd15203   94 IAIDRYQLIVYPTRPRMSKRHALL--IIALIWILSLLLSLP--LAIFQELSDVPIEILPYCGYFcteswpssssrLIYTI 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 245 AVA---FYIPMSVMLFMYYQIYKaarksaakhkfpgfprvepdsvialngivKLQKEVEECANLSRLLKHERKNISifKR 321
Cdd:cd15203  170 SVLvlqFVIPLLIISFCYFRISL-----------------------------KLRKRVKKKRGKRTLSSRRRRSEL--RR 218
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966963638 322 EQKAATTLGIIVGAFTVCWLPFFLLSTARPFicgtscSCIPLWVERTFL-------WLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15203  219 KRRTNRLLIAMVVVFAVCWLPLNLFNLLRDF------EPLPQIDGRHFYliflichLIAMSSACVNPLLYGWLNDNFR 290
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
98-387 2.86e-33

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 126.51  E-value: 2.86e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15318   17 GNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPF-STIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHLCFIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFG---------WAQNVNDDKVC--LISQDFGYTIYSTav 246
Cdd:cd15318   96 IDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTVYTSVFLYTkaveeglaeLLTSVPCVGSCqlLYNKLWGWLNFPV-- 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 247 aFYIPMSVMLFMYYQIYKAARKSAakhkfpgfprvepdsvialngivklqkevEECANLSRLLKHERknisifKREQKAA 326
Cdd:cd15318  174 -FFIPCLIMIGLYVKIFIVAKRQA-----------------------------RAIASLLSDTNGAS------KRERKAA 217
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966963638 327 TTLGIIVGAFTVCWLPFFLLSTARPFICGTScsciPLWVERTFLWLGYANSLINPFIYAFF 387
Cdd:cd15318  218 KTLGIAVGVYLLCWLPFTIDTMVDSLLNFIT----PPLLFDIIIWFAYFNSACNPLIYVFS 274
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
98-395 5.17e-33

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 125.82  E-value: 5.17e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFvSVTDLIGgkwIFGHFFCNVFIAMDVMCCTA-SIMTLCVI 176
Cdd:cd15068   17 GNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPF-AITISTG---FCAACHGCLFIACFVLVLTQsSIFSLLAI 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFG---------------YTI 241
Cdd:cd15068   93 AIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGegqvaclfedvvpmnYMV 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 242 YSTAVA-FYIPMSVMLFMYYQIYKAARKSaakhkfpgfprvepdsvialngiVKLQKEVEECANLSRllkherkniSIFK 320
Cdd:cd15068  173 YFNFFAcVLVPLLLMLGVYLRIFLAARRQ-----------------------LKQMESQPLPGERAR---------STLQ 220
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966963638 321 REQKAATTLGIIVGAFTVCWLPFFLLSTArPFICgTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15068  221 KEVHAAKSLAIIVGLFALCWLPLHIINCF-TFFC-PDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTF 293
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
97-343 1.38e-31

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 122.06  E-value: 1.38e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPfVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15083   16 VGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCP-LMVISSFSGRWIFGKTGCDMYGFSGGLFGIMSINTLAAI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDF--------GYTIYSTAVAF 248
Cdd:cd15083   95 AVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFGWSRYVLEGLLTSCSFDYlsrddanrSYVICLLIFGF 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 249 YIPMSVMLFMYYQIYKAARKSAakhkfpgfprvepdsvialngivKLQKEVEECANLSRLLKHERKNisifKREQKAATT 328
Cdd:cd15083  175 VLPLLIIIYCYSFIFRAVRRHE-----------------------KAMKEMAKRFSKSELSSPKARR----QAEVKTAKI 227
                        250
                 ....*....|....*
gi 966963638 329 LGIIVGAFTVCWLPF 343
Cdd:cd15083  228 ALLLVLLFCLAWTPY 242
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
98-393 4.48e-31

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 120.42  E-value: 4.48e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGkWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15207   17 GNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVDNILTG-WPFGDVMCKLSPLVQGVSVAASVFTLVAIA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPlTYPvRQNGKCMAKMILSVWLLSASITLPPLFgwaqnVNDDKVCLISQDFGYTI-------------YST 244
Cdd:cd15207   96 VDRYRAVVHP-TEP-KLTNRQAFVIIVAIWVLALAIMIPQAL-----VLEVKEYQFFRGQTVHIcvefwpsdeyrkaYTT 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 245 A---VAFYIPMSVMLFMY----YQIYKAARKSAAKHkfpgfprvepdsvialngivklqkEVEECANLSrllkheRKNIS 317
Cdd:cd15207  169 SlfvLCYVAPLLIIAVLYvrigYRLWFKPVPGGGSA------------------------SREAQAAVS------KKKVR 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 318 IFKreqkaatTLGIIVGAFTVCWLPFFLLSTARPFicgtscSCIPLWVERTFL--------WLGYANSLINPFIYAFFNR 389
Cdd:cd15207  219 VIK-------MLIVVVVLFALSWLPLHTVTMLDDF------GNLSPNQREVLYvyiypiahWLAYFNSCVNPIVYGYFNR 285

                 ....
gi 966963638 390 DLRT 393
Cdd:cd15207  286 NFRK 289
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
98-392 1.16e-30

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 119.32  E-value: 1.16e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd14970   17 GNSLVIYVILRYSKMKTVTNIYILNLAVADE-LFLLGLPF-LATSYLLGYWPFGEVMCKIVLSVDAYNMFTSIFCLTVMS 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNgKCMAKMI-LSVWLLSASITLP-PLFGWAQNVNDDKV-CLIS----QDFG---YTIYSTAVA 247
Cdd:cd14970   95 VDRYLAVVHPVKSLRFRT-PRKAKLVsLCVWALSLVLGLPvIIFARTLQEEGGTIsCNLQwpdpPDYWgrvFTIYTFVLG 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 248 FYIPMSVMLFMYYQIYKAARKSAakhkfpgfprvepdsvialngivklqkeveecanlsrlLKHERKNISIFKREQKAAT 327
Cdd:cd14970  174 FAVPLLVITVCYSLIIRRLRSSR--------------------------------------NLSTSGAREKRRARRKVTR 215
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966963638 328 TLGIIVGAFTVCWLPFFLLSTARpFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd14970  216 LVLVVVAVFVVCWLPFHVFQIVR-LLIDPPETLTVVGVFLFCIALSYANSCLNPILYAFLDENFR 279
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
98-392 1.86e-29

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 116.38  E-value: 1.86e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd14992   17 GNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPF-NFTYVVSLSWEYGHFLCKIVNYLRTVSVYASSLTLTAIA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLF-------GWAQNVNDDKVC---LISQDFGYTIYS---T 244
Cdd:cd14992   96 FDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYyattevlFSVKNQEKIFCCqipPVDNKTYEKVYFlliF 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 245 AVAFYIPMSVMLFMYYQIYKAARKSaakhKFPGFPrvepdsvialngivklQKEVEecanlSRLLKHERKNISIfkreqk 324
Cdd:cd14992  176 VVIFVLPLIVMTLAYARISRELWFR----KVPGFS----------------IKEVE-----RKRLKCKRRVIKM------ 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966963638 325 aattLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd14992  225 ----LVCVVVLFVICWLPFHLFFLLRDFFPLIMKEKHTLQVYYFLHWIAMSNSMYNPIIYVTLNNNFR 288
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
98-394 2.41e-29

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 115.97  E-value: 2.41e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIgGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15336   17 GNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLH-KRWIFGEKGCELYAFCGALFGITSMITLLAIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDkvCLISQDFGYTIYSTAV----------A 247
Cdd:cd15336   96 LDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPPLFGWSAYVPEG--LLTSCTWDYMTFTPSVraytmllfcfV 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 248 FYIPMSVMLFMYYQIYKAARKSAakhkfpgfprvepdsvialngivklqKEVEE--CANLSRLLKHERKnisiFKREQKA 325
Cdd:cd15336  174 FFIPLGIIIYCYLFIFLAIRSTG--------------------------REVQKlgSQDRKEKAKQYQR----MKNEWKM 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 326 ATTLGIIVGAFTVCWLPFfllstarpficgtscSCIPLwvertFLWLGYANSLI-----------------NPFIYAFFN 388
Cdd:cd15336  224 AKIAFVVILLFVLSWSPY---------------ACVAL-----IAWAGYAHLLTpymksvpaviakasaiyNPIIYAITH 283

                 ....*.
gi 966963638 389 RDLRTT 394
Cdd:cd15336  284 PKYREA 289
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
97-394 6.84e-29

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 113.91  E-value: 6.84e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIgGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15001   15 IGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFS-PTWSLGAFLCKAVAYLQLLSFICSVLTLTAI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFG-------WAQNVNDDKVCLISQDFG----YTIYSTA 245
Cdd:cd15001   94 SIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGqglvryeSENGVTVYHCQKAWPSTLysrlYVVYLAI 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 246 VAFYIPMSVMLFMYyqiykaarksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisIFKREQKA 325
Cdd:cd15001  174 VIFFIPLIVMTFAY----------------------------------------------------------ARDTRKQV 195
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 326 ATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLW-VERTFLWLGYANSLINPFIYAFFNRDLRTT 394
Cdd:cd15001  196 IKMLISVVVLFAVCWGPLLIDNLLVSFDVISTLHTQALKyMRIAFHLLSYANSCINPIIYAFMSKNFRSS 265
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
98-395 1.51e-28

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 113.19  E-value: 1.51e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTdLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15298   17 GNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVY-IIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGW----AQNVNDDKVCLIS--QDFGYTIYSTAVAFYIP 251
Cdd:cd15298   96 FDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWqfvvGKRTVPDNQCFIQflSNPAVTFGTAIAAFYLP 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 252 MSVMLFMYYQIYKAArksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisifKREQKAATTLGI 331
Cdd:cd15298  176 VVIMTVLYIHISLAS-----------------------------------------------------ARERKVTRTIFA 202
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966963638 332 IVGAFTVCWLPFFLLstarpFICGTSC-SCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15298  203 ILLAFILTWTPYNVM-----VLVNTFCqSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTF 262
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
97-392 1.96e-28

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 113.16  E-value: 1.96e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSvTDLIGGKWIFGHFFC--NVFIAMDVMCctASIMTLC 174
Cdd:cd15390   16 GGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNF-TYLLYNDWPFGLFYCkfSNFVAITTVA--ASVFTLM 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 175 VISIDRYLGITRPLTYPVRQngKCMAKMILSVWLLSASITLPPLFG------WAQNVNDDKVCLIS--------QDFGYT 240
Cdd:cd15390   93 AISIDRYIAIVHPLRPRLSR--RTTKIAIAVIWLASFLLALPQLLYsttetyYYYTGSERTVCFIAwpdgpnslQDFVYN 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 241 IYSTAVAFYIPMSVMLFMYYQIYKAARKSaakhkfpgfprvepdsvialngivklqKEVEECanlsrllkHERKNISIfK 320
Cdd:cd15390  171 IVLFVVTYFLPLIIMAVAYTRVGVELWGS---------------------------KTIGEN--------TPRQLESV-R 214
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966963638 321 REQKAATTLGIIVGAFTVCWLP---FFLLSTARPFIcgtSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15390  215 AKRKVVKMMIVVVVIFAICWLPyhlYFILTYLYPDI---NSWKYIQQIYLAIYWLAMSNSMYNPIIYCWMNKRFR 286
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
99-394 3.76e-27

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 109.30  E-value: 3.76e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADL-----SVAVAVMPFVSVTDLIGGKWIFghFFCNVFIAMdvmccTASIMTL 173
Cdd:cd14972   16 NSLVLAAIIKNRRLHKPMYILIANLAAADLlagiaFVFTFLSVLLVSLTPSPATWLL--RKGSLVLSL-----LASAYSL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 174 CVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCliSQDFGYTIYS----TAVAFY 249
Cdd:cd14972   89 LAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLPVLGWNCVLCDQESC--SPLGPGLPKSylvlILVFFF 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 250 IPMSVMLFMYYQIYKAARKSAakhkfpgfprvepdSVIALNgivklqkeveecanlsrllkHERKNISIFKREQKAATTL 329
Cdd:cd14972  167 IALVIIVFLYVRIFWCLWRHA--------------NAIAAR--------------------QEAAVPAQPSTSRKLAKTV 212
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966963638 330 GIIVGAFTVCWLPFFLLSTARPFICGTscsCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTT 394
Cdd:cd14972  213 VIVLGVFLVCWLPLLILLVLDVLCPSV---CDIQAVFYYFLVLALLNSAINPIIYAFRLKEMRRA 274
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
98-392 1.04e-26

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 107.72  E-value: 1.04e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVsVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15214   16 GNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFV-VTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGAIA 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDD--KVCLIS--QDFGYTIYSTAVAFYIPMS 253
Cdd:cd15214   95 IDRYYAVLYPMVYPMKITGNRAVLALVYIWLHSLIGCLPPLFGWSSLEFDRfkWMCVAAwhKEAGYTAFWQVWCALLPFV 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 254 VMLFMYYQIYKAARKSaakhkfpgfprvepdsvialngivklqkeveECanlsrllkherknisifkreqKAATTLGIIV 333
Cdd:cd15214  175 VMLVCYGFIFRVARAN-------------------------------QC---------------------KAFITILVVL 202
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966963638 334 GAFTVCWLPFFLLSTARPFICGTSCSCIplwVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15214  203 GAFVTTWGPYMVVISTEALWGKNSVSPQ---LETLATWLSFTSAVCHPLIYGLWNKTVR 258
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
97-268 1.13e-26

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 108.43  E-value: 1.13e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVaVAVMPFVSVTDLIGGkWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15079   16 LGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLM-MIKMPIFIYNSFYEG-WALGPLGCQIYAFLGSLSGIGSIWTNAAI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAkMILSVWLLSASITLPPL-FGWAQNVNDDKV--C---LISQDFG---YTIYSTAVA 247
Cdd:cd15079   94 AYDRYNVIVKPLNGNPLTRGKALL-LILFIWLYALPWALLPLlFGWGRYVPEGFLtsCsfdYLTRDWNtrsFVATIFVFA 172
                        170       180
                 ....*....|....*....|.
gi 966963638 248 FYIPMSVMLFMYYQIYKAARK 268
Cdd:cd15079  173 YVIPLIIIIYCYSFIVKAVFA 193
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
98-393 8.42e-26

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 105.91  E-value: 8.42e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15392   17 GNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIALLILQYWPFGEFMCPVVNYLQAVSVFVSAFTLVAIS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMakMILSVWLLSASITLPPL----FGWAQNVNDDK-VCL-----ISQDFGYTIYSTAVA 247
Cdd:cd15392   97 IDRYVAIMWPLRPRMTKRQALL--LIAVIWIFALATALPIAitsrLFEDSNASCGQyICTeswpsDTNRYIYSLVLMILQ 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 248 FYIPMSVMLFMYYQIykaARKSAAKhKFPGfprvepdsvialngivklqkEVEECANlSRLLKHERKNISIFKreqkaat 327
Cdd:cd15392  175 YFVPLAVLVFTYTRI---GIVVWAK-RTPG--------------------EAENNRD-QRMAESKRKLVKMMI------- 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966963638 328 tlgIIVGAFTVCWLPFFLLSTARP-FICGTSCSCIP-LWVerTFLWLGYANSLINPFIYAFFNRDLRT 393
Cdd:cd15392  223 ---TVVAIFALCWLPLNILNLVGDhDESIYSWPYIPyLWL--AAHWLAMSHCCYNPFIYCWMNAKFRN 285
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
97-392 1.91e-25

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 105.06  E-value: 1.91e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGkWIFGHFFCN-VFIAMDVmCCTASIMTLCV 175
Cdd:cd15095   16 AGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVPFTAALYATPS-WVFGDFMCKfVNYMMQV-TVQATCLTLTA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 176 ISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDK----VCL---ISQDF--GYTIYSTAV 246
Cdd:cd15095   94 LSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAIYYRLEEGYWYgpqtYCRevwPSKAFqkAYMIYTVLL 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 247 AFYIPMSVMLFMYYQIykaarksaakhkfpgfprvepdsvialngIVKLQKEVEECANLSRLLKHERKNisifkreQKAA 326
Cdd:cd15095  174 TYVIPLAIIAVCYGLI-----------------------------LRRLWRRSVDGNNQSEQLSERALR-------QKRK 217
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966963638 327 TTLGII--VGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15095  218 VTRMVIvvVVLFAICWLPNHVLNLWQRFDPNFPETYATYALKIAALCLSYANSAVNPFVYAFMGENFR 285
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
98-393 2.29e-25

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 104.43  E-value: 2.29e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLiGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15073   17 SNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDL-HGSWKFGYAGCQWYAFLNIFFGMASIGLLTVVA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPvRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDF--------GYTIYSTAVAFY 249
Cdd:cd15073   96 VDRYLTICRPDLGR-KMTTNTYTVMILLAWTNAFFWAAMPLVGWASYALDPTGATCTINWrkndssfvSYTMSVIVVNFI 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 250 IPMSVMLFMYYQIYKAARKSAAkhkfpgfprvepdsvialngivklqkeveecanlSRLLKHERKNISifkrEQKAATTL 329
Cdd:cd15073  175 VPLAVMFYCYYNVSRFVKKVLA----------------------------------SDCLESVNIDWT----DQNDVTKM 216
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966963638 330 GII-VGAFTVCWLPFFLLSTarpFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRT 393
Cdd:cd15073  217 SVImIVMFLVAWSPYSIVCL---WASFGEPKKIPPWMAIIPPLFAKSSTFYNPCIYVIANKKFRR 278
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
98-384 6.99e-25

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 102.83  E-value: 6.99e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTdLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15213   17 GNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAVT-IITGRWIFGDIFCRISAMLYWFFVLEGVAILLIIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKcmaKMILSVWLLSASITLPPLFGWA--QNVNDDKVCLI-----SQDFGYTIYSTAVAFYI 250
Cdd:cd15213   96 VDRYLIIVQRQDKLNPHRAK---ILIAVSWVLSFCVSFPPLVGWGkyEFPPRAPQCVLgytesPADRIYVVLLLVAVFFI 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 251 PMSVMLFMYYQIYKAARKsaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisiFKreQKAATTLG 330
Cdd:cd15213  173 PFLIMLYSYFCILNTVRS--------------------------------------------------FK--TRAFTTIL 200
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 966963638 331 IIVGAFTVCWLPFFLLSTARPFI-CGTSCSCIPLWVertfLWLGYANSLINPFIY 384
Cdd:cd15213  201 ILFIGFSVCWLPYTVYSLLSVFSrYSSSFYVISTCL----LWLSYLKSAFNPVIY 251
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
97-392 9.27e-25

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 103.22  E-value: 9.27e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMpfvsVTDLI---GGKWIFGHFFCNVFIAMDVMCCTASIMTL 173
Cdd:cd14986   16 VGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTV----LTQIIweaTGEWVAGDVLCRIVKYLQVVGLFASTYIL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 174 CVISIDRYLGITRPLTypVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKV--C--LISQDFGYTIYSTAVAFY 249
Cdd:cd14986   92 VSMSLDRYQAIVKPMS--SLKPRKRARLMIVVAWVLSFLFSIPQLVIFVERELGDGVhqCwsSFYTPWQRKVYITWLATY 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 250 ---IPMSVMLFMYYQI-YKAARKSAAKHKFPGFPRvepdsvialngivklqkeveecANLSRLLKHERKNISIFKR-EQK 324
Cdd:cd14986  170 vfvIPLIILSYCYGRIlRTIWIRSRQKTDRPIAPT----------------------AMSCRSVSCVSSRVSLISRaKIK 227
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966963638 325 AATTLGIIVGAFTVCWLPFFLLSTARPFicgTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd14986  228 TIKMTLVIILAFILCWTPYFIVQLLDVY---AGMQQLENDAYVVSETLASLNSALNPLIYGFFSSHLS 292
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
97-384 1.72e-24

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 101.79  E-value: 1.72e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPfVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15296   16 LGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIP-LYIPYVLTGRWKFGRGLCKLWLVVDYLLCTASVFNIVLI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMA--KMILsVWLLSASITLPPLFGW----AQNVNDDKVCLIsqDFGYTIY----STAV 246
Cdd:cd15296   95 SYDRFLSVTRAVSYRAQKGMTRQAvlKMVL-VWVLAFLLYGPAIISWeyiaGGSIIPEGECYA--EFFYNWYflmtASTL 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 247 AFYIPMSVMLFMYYQIYKAARKsaakhkfpgfprvepdsvialngivklqkeveECANLSrllkherknisifkREQKAA 326
Cdd:cd15296  172 EFFTPFISVTYFNLSIYLNIQK--------------------------------RRFRLS--------------RDKKVA 205
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966963638 327 TTLGIIVGAFTVCWLPFFLLSTARPFICGTscsCIPLWVERTFLWLGYANSLINPFIY 384
Cdd:cd15296  206 KSLAIIVCVFGLCWAPYTLLMIIRAACHGH---CVPDYWYETSFWLLWVNSAINPVLY 260
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
97-392 2.08e-24

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 102.09  E-value: 2.08e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPfvsvTDLIGG---KWIFGHFFCNVFIAMDVMCCTASIMTL 173
Cdd:cd15195   16 AGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMP----MDAVWNytvEWLAGDLMCRVMMFLKQFGMYLSSFML 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 174 CVISIDRYLGITRPLTypVRQNGKCMAKMILSVWLLSASITLPPLF------------GWAQNVNDDKVCLISQDFGYTI 241
Cdd:cd15195   92 VVIALDRVFAILSPLS--ANQARKRVKIMLTVAWVLSALCSIPQSFifsvlrkmpeqpGFHQCVDFGSAPTKKQERLYYF 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 242 YSTAVAFYIPMSVMLFMYyqiykaarksaakhkfpgfprvepdsVIALNGIVKLQKEveecANLSRLLKHERKNISIFKR 321
Cdd:cd15195  170 FTMILSFVIPLIITVTCY--------------------------LLILFEISKMAKR----ARDTPISNRRRSRTNSLER 219
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966963638 322 EQKAATTL-GIIVGAFTVCWLPFFLLSTARPFIcGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15195  220 ARMRTLRMtALIVLTFIVCWGPYYVLGLWYWFD-KESIKNLPPALSHIMFLLGYLNPCLHPIIYGVFMKEIR 290
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
97-392 3.70e-24

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 101.63  E-value: 3.70e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAvAVMPFVSVT-DLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCV 175
Cdd:cd15337   16 IGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFS-AVNGFPLKTiSSFNKKWIWGKVACELYGFAGGIFGFMSITTLAA 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 176 ISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVC-----LISQDFGYTIYSTAV---A 247
Cdd:cd15337   95 ISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFGWGRYVPEGFQTsctfdYLSRDLNNRLFILGLfifG 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 248 FYIPMSVMLFMYYQIYKAARKSAakhkfpgfprvepdsvialngivklqKEVEECANlSRLLKHERKNISIFKREQKAAT 327
Cdd:cd15337  175 FLCPLLIIIFCYVNIIRAVRNHE--------------------------KEMTQTAK-SGMGKDTEKNDARKKAEIRIAK 227
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 328 TLGIIVGAFTVCWLPFF---LLSTARP--FICGTSCScIPLWVERTflwlgyaNSLINPFIYAFFNRDLR 392
Cdd:cd15337  228 VAIILISLFLLSWTPYAvvaLLGQFGPayWITPYVSE-LPVMFAKA-------SAIYNPIIYALSHPKFR 289
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
98-395 4.78e-24

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 101.31  E-value: 4.78e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDlIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15208   17 GNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVD-VTETWFFGQVLCKIIPYLQTVSVSVSVLTLSCIA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYpvRQNGKCMAKMILSVWLLSASITLP--------PLFGWAQNVNDDKVC-----LISQDFGYTIYST 244
Cdd:cd15208   96 LDRWYAICHPLMF--KSTAKRARVSILIIWIVSLLIMIPqaivmecsRVVPLANKTILLTVCderwsDSIYQKVYHICFF 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 245 AVAFYIPMSVMLFMYYQIykaARKSAAKhKFPGfprvePDSVIALNGIvklqkeveecANLSRLLKHERKNIsifKREQK 324
Cdd:cd15208  174 LVTYLLPLCLMILAYFQI---FRKLWCR-QIPG-----TSSVVQRKWN----------KPRKSAVAAEEKQL---RSRRK 231
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966963638 325 AATTLGIIVGAFTVCWLPFFLLSTARPFicGTSCSCIPLWVERTFL---WLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15208  232 TAKMLIVVVIMFAICYLPVHLLNILRYV--FGLFTVDRETIYAWFLfshWLVYANSAINPIIYNFMSGKFREEF 303
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
102-392 5.04e-24

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 100.30  E-value: 5.04e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 102 VVISVCFVKK--LRQPSNYLIVSLALADLSVAVAVMPFVSVTDLiGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISID 179
Cdd:cd15215   18 IVLLLVFQRKpqLLQVANRFIFNLLVADLLQTVLVMPWVIATSV-PLFWPLDSHLCTALVVLMHLFAFAGVNTIVVVSVD 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 180 RYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDK--VC--LISQDFGYTIYSTAVAFYIPMSVM 255
Cdd:cd15215   97 RYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPPLYGWGQAAFDERnaLCsvIWGSSYSYTILSVVSSFVLPVIIM 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 256 LFMYYQIYKAARKsaakhkfpgfprvepdsvialngivklqkeVEECanlsrllkherknisifkreqKAATTLGIIVGA 335
Cdd:cd15215  177 LACYSMVFRAARR------------------------------CYHC---------------------KAAKVIFIIIFS 205
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 336 FTVCWLPFFLLSTarpfICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15215  206 YVLSMGPYSFLSV----LAVWVDTQVPQWVISIILWLFFLQCCIHPYIYGYMHKSIK 258
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
98-395 5.66e-24

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 100.03  E-value: 5.66e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTdLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15210   17 GNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAAST-FLHQAWIHGETLCRVFPLLRYGLVAVSLLTLVLIT 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFG-WAQNVNDDKVCLIS-----QDFGYTIYSTAVAFYIP 251
Cdd:cd15210   96 LNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLPLWLGiWGRFGLDPKVCSCSilrdkKGRSPKTFLFVFGFVLP 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 252 MSVMLFMYYqiykaarksaakhkfpgfprvepdsvialngivklqkeveeCANLSRLLKherknisifkreqkaatTLGI 331
Cdd:cd15210  176 CLVIIICYA-----------------------------------------RREDRRLTR-----------------MMLV 197
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966963638 332 IVGAFTVCWLPFFLLSTARPficgtscSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15210  198 IFLCFLVCYLPITLVNVFDD-------EVAPPVLHIIAYVLIWLSSCINPIIYVAMNRQYRQAY 254
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
98-393 1.38e-23

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 99.76  E-value: 1.38e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd14985   17 GNLFVVWVFLFPRGPKRVADIFIANLAAADL-VFVLTLPLWATYTANQYDWPFGAFLCKVSSYVISVNMFASIFLLTCMS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPL-FGWAQNVNDDKVCLISQDF-------GYTIYSTAVAFY 249
Cdd:cd14985   96 VDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFlLRSLQAIENLNKTACIMLYpheawhfGLSLELNILGFV 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 250 IPMSVMLFMYYQIYKAARKSAakhkfpgfprvepdsvialngivklqkeveecanlSRLLKHERKNISIFKreqkaatTL 329
Cdd:cd14985  176 LPLLIILTCYFHIARSLRKRY-----------------------------------ERTGKNGRKRRKSLK-------II 213
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966963638 330 GIIVGAFTVCWLPFFLLST-ARPFICGTSCSCIPLWVERTFL----WLGYANSLINPFIYAFFNRDLRT 393
Cdd:cd14985  214 FALVVAFLVCWLPFHFFKFlDFLAQLGAIRPCFWELFLDLGLpiatCLAFTNSCLNPFIYVFVDRRFRQ 282
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
98-399 1.49e-23

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 99.13  E-value: 1.49e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMP-FVSVTdlIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15295   17 GNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPlYIPYT--LTNRWDFGRGLCVFWLVIDYLLCTASVYNIVLI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKC-MAKMILSVWLLSASITLPPLFGWAQNVNDDKVC---LISQDFgYTIYSTAVAFYIPM 252
Cdd:cd15295   95 SYDRYQSVSNAVSYRNQQTATLrIVTQMVAVWVLAFLVHGPAILVSDSWKTEDGECepeFFSNWY-ILAITSVLEFLVPV 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 253 SVMLFMYYQIYKAARKsaakhkfpgfprvepdsvialngivklqkeveecanlsRLlkherknisifkREQKAATTLGII 332
Cdd:cd15295  174 ILVAYFNTQIYWSLWK--------------------------------------RL------------RDRKLAKSLAII 203
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966963638 333 VGAFTVCWLPFFLLSTARPFicgtsCSCIP--LWVERTFlWLGYANSLINPFIYAFFNRDLRTTYRSLL 399
Cdd:cd15295  204 LGTFAICWAPYSLFTIIRAA-----CEKHRgsPWYNFAF-WLQWFNSFINPFLYPLCHKRFRKAFLKIF 266
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
98-386 1.73e-23

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 99.26  E-value: 1.73e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAvMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd14982   17 GNILALWVFLRKMKKRSPTTIYMINLALADLLFVLT-LPFRIYYYLNGGWWPFGDFLCRLTGLLFYINMYGSILFLTCIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNV--NDDKVCL------ISQDFGYTIYSTAVAFY 249
Cdd:cd14982   96 VDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRSTIAkeNNSTTCFeflsewLASAAPIVLIALVVGFL 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 250 IPMSVMLFMYYQIYKAarksaakhkfpgfprvepdsvialngivklqkeveecanLSRLLKHERKNIsifkREQKAATTL 329
Cdd:cd14982  176 IPLLIILVCYSLIIRA---------------------------------------LRRRSKQSQKSV----RKRKALRMI 212
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966963638 330 GIIVGAFTVCWLPF-----FLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAF 386
Cdd:cd14982  213 LIVLAVFLVCFLPYhvtriLYLLVRLSFIADCSARNSLYKAYRITLCLASLNSCLDPLIYYF 274
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
97-392 1.91e-23

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 99.47  E-value: 1.91e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDlIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15205   16 FGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQN-ISSNWLGGAFMCKMVPFVQSTAVVTSILTMTCI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDD-------KVCL-----ISQDFGYTIYST 244
Cdd:cd15205   95 AVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPMLFVQQLEVKYDflyekrhVCCLerwysPTQQKIYTTFIL 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 245 AVAFYIPMSVMLFMYYQIykaarksaaKHKFPGFPRVEPDSVIALNgivklqkeveecanlsrllkHERKNISIFKREQK 324
Cdd:cd15205  175 VILFLLPLTTMLFLYSRI---------GYELWIKKRVGDASVLQTI--------------------HGIEMSKISRKKKR 225
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966963638 325 AATTLGIIVGAFTVCWLPFFLLSTARPF------ICGTSCSCIPLWVErtflWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15205  226 AVKMMVTVVLLFAVCWAPFHVVHMMIEYsnlenkYDGVTIKLIFAIVQ----LIGFSNSFNNPIVYAFMNENFK 295
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
98-392 9.38e-23

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 97.35  E-value: 9.38e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15074   17 GNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPL-AIISAFAHRWLFGDIGCVFYGFCGFLFGCCSINTLTAIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPlTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQ----------NVNDDKVCLISQDFGYTIYSTAVA 247
Cdd:cd15074   96 IYRYLKICHP-PYGPKLSRRHVCIVIVAIWLYALFWAVAPLVGWGSygpepfgtscSIDWTGASASVGGMSYIISIFIFC 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 248 FYIPMSVMLFMYYQIYKAARKSaakhkfpgfprvepdsvialngivklQKEVEECANLSrllKHERKNisifkrEQKAAT 327
Cdd:cd15074  175 YLLPVLIIVFSYVKIIRKVKSS--------------------------RKRVAGFDSRS---KRQHKI------ERKVTK 219
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966963638 328 TLGIIVGAFTVCWLPFFLLSTARPFICGTScscIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15074  220 VAVLICAGFLIAWTPYAVVSMWSAFGSPDS---VPILASILPALFAKSSCMYNPIIYLLFSSKFR 281
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
98-392 1.24e-22

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 97.23  E-value: 1.24e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTdLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15403   17 GNAIVCLIVYQKPAMRSAINLLLATLAFSDIMLSLLCMPFTAVT-IITVDWHFGAHFCRISAMLYWFFVLEGVAILLIIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRpltypvRQN--GKCMAKMILSV-WLLSASITLPPLFGWAQNVNDDKV--CLI-----SQDFGYTIYSTAVA 247
Cdd:cd15403   96 VDRFLIIVQ------RQDklNPHRAKVMIAIsWVLSFCISFPSVVGWTLVEVPARApqCVLgytesPADRVYAVLLVVAV 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 248 FYIPMSVMLFMYYQIYKAARKSAAK-HKFPGFPRVEPDSVIALNGivkLQKEVEECANLSrllkherknisiFKreQKAA 326
Cdd:cd15403  170 FFVPFSIMLYSYLCILNTVRRNAVRiHNHADSLCLSQVSKLGLMG---LQRPHQMNVDMS------------FK--TRAF 232
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 327 TTLGIIVGAFTVCWLP---FFLLST-ARPFICGTSCSCIPLWVertfLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15403  233 TTILILFVGFSLCWLPhtvFSLLSVfSRRFYYSSSFYPISTCV----LWLSYLKSVFNPVIYCWRIKKFR 298
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
98-395 1.41e-22

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 96.77  E-value: 1.41e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLiggKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15070   17 GNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIVVSL---GVTIHFYSCLFMSCLLVVFTHASIMSLLAIA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT---------IYSTAVAF 248
Cdd:cd15070   94 VDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPMFGWNRKPSLESVNTTPLQCQFTsvmrmdymvYFSFFTWI 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 249 YIPMSVMLFMYYQIYKAARKsaakhkfpgfprvepdsvialngivklqkeveecaNLSRLLKHERKNISIFKREQKAATT 328
Cdd:cd15070  174 LIPLVIMCALYVDIFYIIRN-----------------------------------KLSQNATGFRETGAFYGREFKTAKS 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 329 LGIIVGAFTVCWLPFFLLSTARPFicgtsCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15070  219 LALVLFLFAVCWLPLSIINCVVYF-----NPKVPKIALYLGILLSHANSMMNPIVYACKIKKFKETY 280
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
98-392 3.06e-22

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 95.60  E-value: 3.06e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15088   17 GNGIVLYVLVRCSKLRTAPDIFIFNLAVADL-LFMLGMPFLIHQFAIDGQWYFGEVMCKIITALDANNQFTSTYILTAMS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDD--KVCLISQDFG-----YTIYSTAVAFYI 250
Cdd:cd15088   96 VDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSLIYFPDgtTFCYVSLPSPddlywFTIYHFILGFAV 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 251 PMSVMLFMYYQIYKAARKSAAkhkfPGFPRvepdsvialngivklqkeveecanlsrllkherkniSIFKREQKAATTLG 330
Cdd:cd15088  176 PLVVITVCYILILHRLARGVA----PGNQS------------------------------------HGSSRTKRVTKMVI 215
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966963638 331 IIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWverTF-LWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15088  216 LIVVVFIVCWLPFHVVQLVNLAMNRPTLAFEVAY---FLsICLGYANSCLNPFVYILVSENFR 275
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
97-392 3.20e-22

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 96.76  E-value: 3.20e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15005   16 AGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIYGALSCKVIAFLAVLFCFHSAFTLFCI 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLF--GWAQNVNDDKVCLISQ-------DFGYTIYSTAV- 246
Cdd:cd15005   96 AVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFPPVFdvGTYTFIREEDQCTFEHrsykandTLGFMLVLAVVi 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 247 --AFYIPMSVMLFMYY-------QIYKA-----------ARKSAAKHKFPGFPRvePDSVIALNGIVKlqkevEECANLS 306
Cdd:cd15005  176 aaTHLVYLKLLIFLRHhrkmkpaQLVPAisqnwtfhgpgATGQAAANWTAGFGR--GPTPPTLLGIRQ-----AFHSGAR 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 307 RLLKHERknisiFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTScscIPLWVERTFLWLGYANSLINPFIYAF 386
Cdd:cd15005  249 RLLVLDE-----FKMEKRLTRMFYAITLLFLLLWSPYIVACYIRVFVRGYA---VPQGFLTAAVWMTFAQAGVNPIVCFF 320

                 ....*.
gi 966963638 387 FNRDLR 392
Cdd:cd15005  321 FNRELR 326
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
98-392 3.37e-22

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 95.83  E-value: 3.37e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSvTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15096   17 GNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTA-TDYVLPTWPFGDVWCKIVQYLVYVTAYASVYTLVLMS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDK-----VCLISQDFGYTIYSTAVAFY--- 249
Cdd:cd15096   96 LDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANIPVLFLHGVVSYGFSseaysYCTFLTEVGTAAQTFFTSFFlfs 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 250 --IPMSVMLFMYYQIYKAARKSAakhkfPGFPRVEPDSvialngivklqkeveecanlsrllkherknisiFKREQKAAT 327
Cdd:cd15096  176 ylIPLTLICVLYMLMLRRLRRQK-----SPGGRRSAES---------------------------------QRGKRRVTR 217
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966963638 328 TLGIIVGAFTVCWLPF---FLLStarpFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15096  218 LVVVVVVVFAICWLPIhiiLLLK----YYGVLPETVLYVVIQILSNCLAYGNSCVNPILYAFLSQNFR 281
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
97-388 9.96e-22

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 94.40  E-value: 9.96e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIgGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15393   16 VGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALL-QRWVLPRFMCPFCPFVQVLSVNVSVFTLTVI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTypvRQNGKCMAKMILS-VWLLSASITLP-PLFGWAQNVNDDK------VCL---ISQDFG--YTIYS 243
Cdd:cd15393   95 AVDRYRAVIHPLK---ARCSKKSAKIIILiIWILALLVALPvALALRVEELTDKTnngvkpFCLpvgPSDDWWkiYNLYL 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 244 TAVAFYIPMSVMLFMYYQIYKAARKSaakhKFPGFPRVEPDSVIALNgivklqkeveecanlsrllkherknisifkrEQ 323
Cdd:cd15393  172 VCVQYFVPLVIICYAYTRIAVKIWGT----KAPGNAQDVRDDEILKN-------------------------------KK 216
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966963638 324 KAATTLGIIVGAFTVCWLP---FFLLSTARPFICGTSCSCIpLWVERTflWLGYANSLINPFIYAFFN 388
Cdd:cd15393  217 KVIKMLIIVVALFALCWLPlqtYNLLNEIKPEINKYKYINI-IWFCSH--WLAMSNSCYNPFIYGLYN 281
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
98-388 1.11e-21

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 94.45  E-value: 1.11e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFC--NVFIAmdvmCCTASIMTLCV 175
Cdd:cd15212   17 GNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRPGWLFGDRLClaNGFFN----ACFGIVSTLTM 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 176 --ISIDRYLGITR-PLTYPVRQNGkcmAKMILSVWLLSASITLP-PLFGWAQNVNDDKV---CLISQDFG-------YTI 241
Cdd:cd15212   93 tlISFDRYYAIVRqPQGKIGRRRA---LQLLAAAWLTALGFSLPwYLLASAPEYYEKLGfyhCLYVLHSGpsrlgaaYSS 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 242 YSTAVAFYIPMSVMLFMYYQIYKAARKSAAkhkfpgfpRVEPDSVIAlngivklqkeveecanlsRLLKherknisiFKR 321
Cdd:cd15212  170 VLIVLCYLLPFALMCFCHYNICKTVRLSES--------RVRPVTTYA------------------HLLR--------FYS 215
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 322 EQKAATTLGIIVGAFTVCWLPFFLLStarpFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFN 388
Cdd:cd15212  216 EMRTATTVLIMIVFIICCWGPYCLLG----LVAAAGGYQFPPLMDTVAIWMAWANGAINPLIYAIRN 278
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
98-395 6.14e-21

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 92.27  E-value: 6.14e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVsVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15402   17 GNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLV-LTSIFHNGWNLGYLHCQISGFLMGLSVIGSIFNITGIA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLF-GWAQNVNDDKVCLISQDF--GYTIYSTAVAFYIPMSV 254
Cdd:cd15402   96 INRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVAAIVPNLFvGSLQYDPRIYSCTFAQSVssAYTIAVVFFHFILPIII 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 255 MLFMYYQIYKAARKSAAkhkfpgfpRVEPDsvialngivklqkeveecaNLSRLLKHERKNIsifkreqkaaTTLGIIVG 334
Cdd:cd15402  176 VTFCYLRIWILVIQVRR--------RVKPD-------------------NKPKLKPHDFRNF----------VTMFVVFV 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966963638 335 AFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15402  219 LFAVCWAPLNFIGLAVAVDPETIVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRREY 279
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
98-394 7.92e-21

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 91.97  E-value: 7.92e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd14997   17 GNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWAREPWLLGEFMCKLVPFVELTVAHASVLTILAIS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLF------GWAQNVNDDKVCLISQD-FGYTIY--STAVAF 248
Cdd:cd14997   97 FERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFitefkeEDFNDGTPVAVCRTPADtFWKVAYilSTIVVF 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 249 YIPMSVMLFMYYqiykaarksaakhkfpgfprvepdSVIA--LNGiVKLQKEVEECANLSRLLKHERKNISIfkreqkaa 326
Cdd:cd14997  177 FVVPLAILSGLY------------------------SVICrrLVG-HPALESRRADAANRHTLRSRRQVVYM-------- 223
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966963638 327 ttLGIIVGAFTVCWLPF------FLLSTARPFIC-GTSCSCIPLWVERTFLwlgYANSLINPFIYAFFNRDLRTT 394
Cdd:cd14997  224 --LITVVVLFFVCLLPFrvvtlwIIFAPDEDLQAlGLEGYLNLLVFCRVMV---YLNSALNPILYNLMSTKFRSA 293
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
98-395 1.28e-20

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 91.65  E-value: 1.28e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd14979   17 GNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYPWAFGDGGCKLYYFLFEACTYATVLTIVALS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLP---------PLFGWAQNVNDDKVCLISQDFGYTIY----ST 244
Cdd:cd14979   97 VERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPilflmgiqyLNGPLPGPVPDSAVCTLVVDRSTFKYvfqvST 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 245 AVAFYIPMSVMLFMYYQI---YKAARKSAAKHKFPGFPRVEPDsvialnGIVKLQKEVeecanlsrllkherknisifkr 321
Cdd:cd14979  177 FIFFVLPMFVISILYFRIgvkLRSMRNIKKGTRAQGTRNVELS------LSQQARRQV---------------------- 228
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966963638 322 eqkaATTLGIIVGAFTVCWLPFFLLstaRPFICGTSCSCIPL-WVERTFLW----LGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd14979  229 ----VKMLGAVVIAFFVCWLPFHAQ---RLMFSYASKEDTFLfDFYQYLYPisgiLFYLSSAINPILYNLMSSRFRVAF 300
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
98-392 1.50e-20

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 91.04  E-value: 1.50e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15391   17 GNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPF-TFTQIMLGHWVFPAPMCPIVLYVQLVSVTASVLTNTAIG 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPL-TYPVRQNGKCmakMILSVWLLSASITLPPLFG-----WAQNVNDDKVCLISQD------FGYTIYSTA 245
Cdd:cd15391   96 IDRFFAVIFPLrSRHTKSRTKC---IIASIWAISFSLSSVQLFAgrtqrYGQYSEGRVLCGESWPgpdtsrSAYTVFVML 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 246 VAFYIPMSVMLFMYYQIykaarksaakhkfpgfprvepdsvialnGIVKLQKEVEECANLSRLLKHERKNISIFKreqka 325
Cdd:cd15391  173 LTYIIPLLILTSTYGYV----------------------------GFRLWNRTAPGNADKGRDDMQIKSKRKVIK----- 219
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966963638 326 atTLGIIVGAFTVCWLPFFLLSTARPF--ICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15391  220 --MLVFVVLMFGICWLPLHLFNLVQDFstVFRNMPQHTTRLIYGACHWIAMSNSFVNPIIYLFMNDSFR 286
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
98-392 3.60e-20

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 90.21  E-value: 3.60e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVK-KLRQPSNYLIVSLALADLSVaVAVMPFVSVTDLIGGKWIFGHFFCN-----VFIAMdvmccTASIM 171
Cdd:cd15190   27 GNGLVLWTVFRSKrKRRRSADTFIANLALADLTF-VVTLPLWAVYTALGYHWPFGSFLCKlssylVFVNM-----YASVF 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 172 TLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPL-FGWAQNVNDDKVCLISQDF------------- 237
Cdd:cd15190  101 CLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLALPALiLRTTSDLEGTNKVICDMDYsgvvsnesewawi 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 238 -GYTIYSTAVAFYIPMSVMLFMYYQIykaARKsaakhkfpgfprvepdsvialngivklqkeveecanLSRLLKHERKni 316
Cdd:cd15190  181 aGLGLSSTVLGFLLPFLIMLTCYFFI---GRT------------------------------------VARHFSKLRR-- 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 317 sifKREQKAATTLGII---VGAFTVCWLPFFLLSTAR--------PFICGTS---------CSCiplwvertflwLGYAN 376
Cdd:cd15190  220 ---KEDKKKRRLLKIIitlVVTFALCWLPFHLVKTLYalmylgilPFSCGFDlflmnahpyATC-----------LAYVN 285
                        330
                 ....*....|....*.
gi 966963638 377 SLINPFIYAFFnrDLR 392
Cdd:cd15190  286 SCLNPFLYAFF--DPR 299
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
98-395 7.52e-20

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 89.20  E-value: 7.52e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGkWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15401   17 GNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNG-WTLGNIHCQISGFLMGLSVIGSVFNITAIA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVnDDKV--CLISQDF--GYTIYSTAVAFYIPMS 253
Cdd:cd15401   96 INRYCYICHSLRYDKLYNMKKTCCYVCLTWVLTLAAIVPNFFVGSLQY-DPRIysCTFAQTVssSYTITVVVVHFIVPLS 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 254 VMLFMYYQIYKAARKsaAKHkfpgfpRVEPDSvialngivklqKEVEECANLSRLLkherknisifkreqkaatTLGIIV 333
Cdd:cd15401  175 IVTFCYLRIWVLVIQ--VKH------RVRQDS-----------KQKLKANDIRNFL------------------TMFVVF 217
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966963638 334 GAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15401  218 VLFAVCWGPLNFIGLAVAINPLKVAPKIPEWLFVLSYFMAYFNSCLNAVIYGVLNQNFRKEY 279
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
98-395 7.72e-20

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 88.82  E-value: 7.72e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVmPFVsVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15970   17 GNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSV-PFL-VTSTLLRHWPFGSLLCRLVLSVDAINMFTSIYCLTVLS 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTyPVRQNGKCMAKMI-LSVWLLSASITLPPLF--GWAQNVNDDKVCLI-----SQDF--GYTIYSTAVA 247
Cdd:cd15970   95 IDRYIAVVHPIK-AARYRRPTVAKMVnLGVWVFSILVILPIIIfsNTAPNSDGSVACNMqmpepSQRWlaVFVVYTFLMG 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 248 FYIPMSVMLFMYYQIYKAARKSAAKHKFpgfprvepdsvialngivklqkeveecanlsrllkHERKnisifKREQKAAT 327
Cdd:cd15970  174 FLLPVIAICLCYILIIVKMRVVALKAGW-----------------------------------QQRK-----RSERKITL 213
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966963638 328 TLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVertflWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15970  214 MVMMVVTVFVICWMPFYVVQLVSVFVGQHDATVSQLSV-----ILGYANSCANPILYGFLSDNFKRSF 276
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
98-395 1.11e-19

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 88.69  E-value: 1.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAvMPFVSVTDLIGGkWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15094   17 GNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIG-LPFLIVTMILKY-WPFGAAMCKIYMVLTSINQFTSSFTLTVMS 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLpPLFGWAQNVND--DKVCLI--------SQDFGYTIYSTAVA 247
Cdd:cd15094   95 ADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVML-PIILYASTVPDsgRYSCTIvwpdssavNGQKAFTLYTFLLG 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 248 FYIPMSVMLFMYYQIykaarksaakhkfpgfprvepdsvialngIVKLQkeveecaNLSRLLKHERKnisifKREQKAAT 327
Cdd:cd15094  174 FAIPLLLISVFYTLV-----------------------------ILRLR-------TVGPKNKSKEK-----RRSHRKVT 212
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966963638 328 TLGI-IVGAFTVCWLPFFLLSTArpFICGTSCSCIPLWVERTFLW---LGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15094  213 RLVLtVISVYIICWLPYWAFQVH--LIFLPPGTDMPKWEILMFLLltvLSYANSMVNPLLYAFLSENFRKSF 282
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
98-392 1.30e-19

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 88.26  E-value: 1.30e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15394   17 GNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEPRGWVFGRFMCYFVFLMQPVTVYVSVFTLTAIA 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGItrplTYPVRQNG--KCMAKMILSVWLLSASITLPPLfgwaqnVNDDKVCLISQDFG---------------YT 240
Cdd:cd15394   97 VDRYYVT----VYPLRRRIsrRTCAYIVAAIWLLSCGLALPAA------AHTYYVEFKGLDFSiceefwfgqekqrlaYA 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 241 IYSTAVAFYIPMSVMLFMYYQIYKAARKsaakhkfpgfpRVEPDSVIAlngivkLQKEVEEcanlsrllkherknisifK 320
Cdd:cd15394  167 CSTLLITYVLPLLAISLSYLRISVKLRN-----------RVVPGSMTQ------SQAEWDR------------------A 211
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966963638 321 REQKAATTLGIIVGAFTVCWLPFFLLSTARPF-ICGTSCSCIPLwVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15394  212 RRRKTFRLLVVVVVAFAICWLPLHIFNVIRDIdIDLIDKQYFNL-IQLLCHWLAMSSACYNPFLYAWLHDSFR 283
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
98-395 1.80e-19

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 87.95  E-value: 1.80e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIgGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15979   17 GNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLM-GTFIFGEVICKAVAYLMGVSVSVSTFSLVAIA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPplfgwaqnvnddkvclisqdfgYTIYSTAVAFYIPMSVMLF 257
Cdd:cd15979   96 IERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIP----------------------YPVYSVTVPVPVGDRPRGH 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 258 MYYQIYKAARKSAAKHKF--------PGFprvepdSVIALNGIVKLQkeveecanLSRLLKHERKNISIfkreqkaattL 329
Cdd:cd15979  154 QCRHAWPSAQVRQAWYVLlllilffiPGV------VMIVAYGLISRE--------LYRGLLAKKRVIRM----------L 209
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966963638 330 GIIVGAFTVCWLPFFLLSTARPF--------ICGTSCSCIPLwvertflwLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15979  210 VVIVAMFFLCWLPIFSANTWRAFdplsahraLSGAPISFIHL--------LSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
97-392 1.82e-19

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 87.85  E-value: 1.82e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPS--NYLIVSLALADLSVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLC 174
Cdd:cd15002   15 AGNLMVIGILLNNARKGKPSliDSLILNLSAADLLLLLFSVPF-RAAAYSKGSWPLGWFVCKTADWFGHACMAAKSFTIA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 175 VISIDRYLGITRPLTYPVRQNGKCMAkMILSVWLLSASITLPP-LFGWAQNVNDDKVCLIS----QDFGYTIYSTA---V 246
Cdd:cd15002   94 VLAKACYMYVVNPTKQVTIKQRRITA-VVASIWVPACLLPLPQwLFRTVKQSEGVYLCILCipplAHEFMSAFVKLyplF 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 247 AFYIPMSVMLFMYYQIYKAARKSAAKhkfpgfprvepdsvialngivklqkeveecanlSRLLKHERknisifkREQKAA 326
Cdd:cd15002  173 VFCLPLTFALFYFWRAYGQCQRRGTK---------------------------------TQNLRNQI-------RSRKLT 212
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 327 TTLGIIVGAFTVCWLPFFLLSTArpFICGTS-CSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15002  213 HMLLSVVLAFTILWLPEWVAWLW--LIHIKSsGSSPPQLFNVLAQLLAFSISSVNPIIFLLMSEEFR 277
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
98-392 3.91e-19

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 86.95  E-value: 3.91e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFV----SVTDLIggkWIFGHFFCNVFIAMDVMCCTASIMTL 173
Cdd:cd15204   17 GNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEmdyyVVRQRS---WTHGDVLCAVVNYLRTVSLYVSTNAL 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 174 CVISIDRYLGITRPLTYPVRQNGKCMakMILSVWLLSASITLP-PLFGWAQ-NVNDDKV-C----LISQDF---GYTIYS 243
Cdd:cd15204   94 LVIAIDRYLVIVHPLKPRMKRRTACV--VIALVWVVSLLLAIPsAVYSKTTpYANQGKIfCgqiwPVDQQAyykAYYLFL 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 244 TAVAFYIPMSVMLFMYYQI-YKAARKSaakhkFPGFprvepdsvialngivklqkeveECANLSRLLKHERKNIsifkre 322
Cdd:cd15204  172 FVLEFVLPVLIMTLCYLRIvRKVWFRR-----VPGQ----------------------QTEQIRRRLRRRRRKV------ 218
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 323 qkaaTTLGIIVGAFTVCWLPFFLLSTARPFICGTscscipLWVERTFLWLGYA-------NSLINPFIYAFFNRDLR 392
Cdd:cd15204  219 ----RLLVVILTAFVLCWAPYYGYAIVRDFFPTL------LSKEKLNTTIFYIvealamsNSMINTVVYVAFNNNIR 285
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
97-387 9.92e-19

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 85.88  E-value: 9.92e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCF-VKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDlIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCV 175
Cdd:cd15383   16 CSNLAVLWSATRnRRRKLSHVRILILHLAAADLLVTFVVMPLDAAWN-VTVQWYAGDLACRLLMFLKLFAMYSSAFVTVV 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 176 ISIDRYLGITRPLTypvRQNGKCMAKMILSV-WLLSASITLPPLFGW----AQNVNDDKVCLIS-------QDFGYTIYS 243
Cdd:cd15383   95 ISLDRHAAILNPLA---IGSARRRNRIMLCAaWGLSALLALPQLFLFhtvtATPPVNFTQCATHgsfpahwQETLYNMFT 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 244 TAVAFYIPMSVMLFMYYQIykaarksaakhkfpgfprvepdsviaLNGIVKLQKEVEECANLSRLLKHERKNISifKREQ 323
Cdd:cd15383  172 FFCLFLLPLLIMIFCYTRI--------------------------LLEISRRMKEKKDSAKNEVALRSSSDNIP--KARM 223
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966963638 324 KAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFF 387
Cdd:cd15383  224 RTLKMTIVIVSSFIVCWTPYYLLGLWYWFSPEMLEQTVPESLSHILFLFGLLNACLDPLIYGLF 287
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
98-395 1.12e-18

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 85.69  E-value: 1.12e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADlSVAVAVMPFVSvTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15092   17 GNCLVMYVILRHTKMKTATNIYIFNLALAD-TLVLLTLPFQG-TDIFLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMS 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPL-TYPVRQNGKcmAKMI-LSVWLLSASITLPPL-FGWAQNVNDDKVCLIS----QDFGYTIYSTAV---A 247
Cdd:cd15092   95 VDRYVAICHPIkALDVRTPHK--AKVVnVCIWALASVVGVPVMvMGSAQVEDEEIECLVEiptpQDYWDPVFGICVflfS 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 248 FYIPMSVMLFMYYQIYKaarksaakhkfpgfprvepdsviALNGIVKLQKEVEECANLSRLLKherknisifkreqkaat 327
Cdd:cd15092  173 FIIPVLIISVCYSLMIR-----------------------RLRGVRLLSGSKEKDRNLRRITR----------------- 212
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966963638 328 TLGIIVGAFTVCWLPFFLLSTARPFICGTScSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15092  213 LVLVVVAVFVGCWTPIQIFVLAQGLGVQPS-SETAVAILRFCTALGYVNSSLNPVLYAFLDENFKACF 279
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
99-392 1.41e-18

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 85.08  E-value: 1.41e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVmpfvsVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISI 178
Cdd:cd15961   18 NAIVVLIIFQNPSLRAPMFLLIGSLALADLLAGIGL-----ILNFIFAYLLQSEAAKLVTVGLIVASFSASVCSLLAITV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 179 DRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWaQNVNDDKVCLISQDFGYTIYST-AVAFYIPMSVMLF 257
Cdd:cd15961   93 DRYLSLYYALTYNSERTVTFTYVMLVLLWGASICLGLLPVMGW-NCLADESTCSVVRPLTKNNAAIlSVSFLLMFALMLQ 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 258 MYYQIYKAARKSAAKhkfpgfprvepdsvIAlngivklqkeveecanlsrlLKHERKNISIFKREQKAATTLGIIVGAFT 337
Cdd:cd15961  172 LYIQICKIVMRHAHQ--------------IA--------------------LQHHFLATSHYVTTRKGVSTLAIILGTFA 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 966963638 338 VCWLPFFLLSTARPFicgtscSCIPLWVERTFLWLGYaNSLINPFIYAFFNRDLR 392
Cdd:cd15961  218 ACWMPFTLYSLIADY------TYPSIYTYATLLPATY-NSIINPVIYAFRNQEIQ 265
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
97-391 2.25e-18

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 84.57  E-value: 2.25e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFVSVTDLIGgkWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd14984   16 VGNSLVLLVLLYYRKLRSMTDVYLLNLALADL-LFVLTLPFWAVYAADG--WVFGSFLCKLVSALYTINFYSGILFLACI 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPlTYPVRQNGKCMAKMI-LSVWLLSASITLPP-LFGWAQNVNDDKVCLISQD--------FGYTIYSTAV 246
Cdd:cd14984   93 SIDRYLAIVHA-VSALRARTLLHGKLTcLGVWALALLLSLPEfIFSQVSEENGSSICSYDYPedtattwkTLLRLLQNIL 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 247 AFYIPMSVMLFMYYQIYKAARKSAAKHKfpgfprvepdsvialNGIVKLqkeveecanlsrllkherknisIFkreqkaa 326
Cdd:cd14984  172 GFLLPLLVMLFCYSRIIRTLLRARNHKK---------------HRALRV----------------------IF------- 207
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966963638 327 ttlgIIVGAFTVCWLPF----FLLSTARPFICGTSCSC---IPLWVERTFLwLGYANSLINPFIYAF----FNRDL 391
Cdd:cd14984  208 ----AVVVVFFLCWLPYnivlLLDTLQLLGIISRSCELsksLDYALQVTES-LAFSHCCLNPVLYAFvgvkFRKYL 278
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
98-392 2.67e-18

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 84.67  E-value: 2.67e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFvKKLRQPS--NYLIVSLALADLSVAVAVMPfVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCV 175
Cdd:cd15382   17 GNLTVLLILLR-NRRRKRSrvNILLMHLAIADLLVTFIMMP-LEIGWAATVAWLAGDFLCRLMLFFRAFGLYLSSFVLVC 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 176 ISIDRYLGITRPL-TYPVRQNGKcmaKMILSVWLLSASITLP----------PLFGW-AQNVNDDKVCLISQDFGYTIYS 243
Cdd:cd15382   95 ISLDRYFAILKPLrLSDARRRGR---IMLAVAWVISFLCSIPqsfifhveshPCVTWfSQCVTFNFFPSHDHELAYNIFN 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 244 TAVAFYIPMSVMLFMYYQI-YKAARKSaakhkfpgfprvepdsvialngivKLQKEVEECANLSRLLkheRKNiSIFKRE 322
Cdd:cd15382  172 MITMYALPLIIIVFCYSLIlCEISRKS------------------------KEKKEDVSEKSSSVRL---RRS-SVGLLE 223
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966963638 323 QKAATTLG---IIVGAFTVCWLPFFLLSTARpFICGTSCSCIPLWVERtFLWL-GYANSLINPFIYAFFNRDLR 392
Cdd:cd15382  224 RARSRTLKmtiVIVLVFIICWTPYFIMSLWY-WFDRESASKVDPRIQK-GLFLfAVSNSCMNPIVYGYFSIDLR 295
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
98-395 8.00e-18

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 83.12  E-value: 8.00e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADlSVAVAVMPFVSVTDLIGgKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15090   17 GNFLVMYVIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSVNYLMG-TWPFGNILCKIVISIDYYNMFTSIFTLCTMS 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRP---LTYPVRQNGKcmakmILSV--WLLSASITLPPLF---GWAQNVNDDKVCLISQDFGY-----TIYST 244
Cdd:cd15090   95 VDRYIAVCHPvkaLDFRTPRNAK-----IVNVcnWILSSAIGLPVMFmatTKYRQGSIDCTLTFSHPSWYwenllKICVF 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 245 AVAFYIPMSVMLFMYYQIykaarksaakhkfpgfprvepdsVIALNGIVKLQKEVEECANLSRLLKherknisifkreqk 324
Cdd:cd15090  170 IFAFIMPVLIITVCYGLM-----------------------ILRLKSVRMLSGSKEKDRNLRRITR-------------- 212
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966963638 325 aatTLGIIVGAFTVCWLPFFLLSTARPFIcgtscsCIPLWVERTFLW-----LGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15090  213 ---MVLVVVAVFIVCWTPIHIYVIIKALV------TIPETTFQTVSWhfciaLGYTNSCLNPVLYAFLDENFKRCF 279
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
98-395 1.01e-17

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 82.90  E-value: 1.01e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGkWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15209   17 GNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNG-WTLGQLHCQASGFIMGLSVIGSIFNITAIA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLF-GWAQNVNDDKVCLISQDFG--YTIYSTAVAFYIPMSV 254
Cdd:cd15209   96 INRYCYICHSLQYDRLYSLRNTCCYLCLTWLLTVLAVLPNFFiGSLQYDPRIYSCTFAQTVStvYTITVVVIHFLLPLLI 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 255 MLFMYYQIYkaARKSAAKHkfpgfpRVEPDsvialngivklQKEVEECANLSRLLkherknisifkreqkaatTLGIIVG 334
Cdd:cd15209  176 VSFCYLRIW--VLVLQVRQ------RVKPD-----------QRPKLKPADVRNFL------------------TMFVVFV 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966963638 335 AFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15209  219 LFAVCWAPLNFIGLAVAINPKEMAPKIPEWLFVASYFMAYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
98-395 1.13e-17

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 82.69  E-value: 1.13e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADlSVAVAVMPFVSvTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15091   17 GNSLVMFVIIRYTKMKTATNIYIFNLALAD-ALVTTTMPFQS-TVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMS 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLT-----YPVRqngkcmAKMI-LSVWLLSASITLPP--LFGWAQNVNDD--KVCLISQDFGYTIYSTAV- 246
Cdd:cd15091   95 VDRYIAVCHPVKaldfrTPLK------AKIInICIWLLSSSVGISAivLGGTKVREDVDstECSLQFPDDDYSWWDTFMk 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 247 ------AFYIPMSVMLFMYYQIykaarksaakhkfpgfprvepdsVIALNGIVKLQKEVEECANLSRLLKherknisifk 320
Cdd:cd15091  169 icvfifAFVIPVLIIIVCYTLM-----------------------ILRLKSVRLLSGSREKDRNLRRITR---------- 215
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 321 reqkaatTLGIIVGAFTVCWLP--FFLLSTArpfICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15091  216 -------LVLVVVAVFVVCWTPihIFILVEA---LGSVSHSTAAVSSYYFCIALGYTNSSLNPILYAFLDENFKRCF 282
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
97-392 1.20e-17

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 82.94  E-value: 1.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15202   16 FGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPF-TFVRAVNNTWIFGLFMCHFSNFAQYCSVHVSAYTLTAI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTypvRQNGKCMAKMILSV-WLLSASITLP-----PLFGWAQNVNDDK-VCLI-------SQDFGYTIY 242
Cdd:cd15202   95 AVDRYQAIMHPLK---PRISKTKAKFIIAViWTLALAFALPhaicsKLETFKYSEDIVRsLCLEdwperadLFWKYYDLA 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 243 STAVAFYIPMSVMLFMYYQIYKAARKSaakhKFPGFPRVEPDsvialngivklqkeveecanlSRLLKHERKNISIfkre 322
Cdd:cd15202  172 LFILQYFLPLLVISFAYARVGIKLWAS----NMPGDATTERY---------------------FALRRKKKKVIKM---- 222
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966963638 323 qkaattLGIIVGAFTVCWLPF---FLLSTARPFICGTSCSCIPLwverTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15202  223 ------LMVVVVLFALCWLPFniyVLLLSSKPDYLIKTINAVYF----AFHWLAMSSTCYNPFIYCWLNERFR 285
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
99-392 1.58e-17

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 82.65  E-value: 1.58e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVaVMPFVSVTDLIGGKWIFGHFFCnVFIAMDV-MCCTASIMTLCVIS 177
Cdd:cd15081   30 NGLVLVATLKFKKLRHPLNWILVNLAIADLGETV-IASTISVVNQIFGYFILGHPMC-VLEGFTVsVCGITGLWSLTIIS 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTyPVRQNGKCMAKMILSVWLLSASITLPPLFGWA-------QNVNDDKVCLISQDFG---YTIYSTAVA 247
Cdd:cd15081  108 WERWVVVCKPFG-NIKFDGKLAIVGIIFSWVWSAVWCAPPIFGWSrywphglKTSCGPDVFSGSSDPGvqsYMIVLMITC 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 248 FYIPMSVMLFMYYQIYKAARKSAAKhkfpgfprvepdsvialngivklQKEVEecanlsrllkherkniSIFKREQKAAT 327
Cdd:cd15081  187 CIIPLAIIILCYLQVWLAIRAVAQQ-----------------------QKESE----------------STQKAEKEVSR 227
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966963638 328 TLGIIVGAFTVCWLPFFLLSTARPFICGTS----CSCIPLWVERTflwlgyaNSLINPFIYAFFNRDLR 392
Cdd:cd15081  228 MVVVMIFAYCFCWGPYTFFACFAAANPGYAfhplAAALPAYFAKS-------ATIYNPIIYVFMNRQFR 289
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
98-395 1.61e-17

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 82.59  E-value: 1.61e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPfVSVTDLIGGKwifGHFFCNVFIAMDVMCCT-ASIMTLCVI 176
Cdd:cd15071   17 GNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIP-LAIIINIGPQ---TEFYSCLMVACPVLILTqSSILALLAI 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGW-----AQNVNDDKVC----LISQDFGYTI---YST 244
Cdd:cd15071   93 AVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVGLTPMFGWnnlnaVERAWAANSSmgelVIKCQFETVIsmeYMV 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 245 AVAFYI----PMSVMLFMYYQIYKAARKSAAKhkfpgfprvepdsvialngivklqkevEECANLSRLLKHerknisiFK 320
Cdd:cd15071  173 YFNFFVwvlpPLLLMLLIYLEVFYLIRKQLNK---------------------------KVSSSSSDPQKY-------YG 218
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966963638 321 REQKAATTLGIIVGAFTVCWLPFFLLSTARPFIcgTSCScIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15071  219 KELKIAKSLALILFLFALSWLPLHILNCITLFC--PSCK-KPMILTYIAIFLTHGNSAMNPIVYAFRIKKFRTTF 290
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
98-392 2.13e-17

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 81.72  E-value: 2.13e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAV-AVMPFVSVtdLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15012   16 GNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIfCVLQNLSI--YLIPSWPFGEVLCRMYQFVHSLSYTASIGILVVI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPL--FGWAQNVNDDKV------CLISQDFGYTIYSTA--- 245
Cdd:cd15012   94 SVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFvfSQTVEILVTQDGqeeeicVLDREMFNSKLYDTInfi 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 246 VAFYIPMSVMLFMYYQIYKAARKSaakhkfpgfprvepDSVIALNGIVKLqkeveecanlsrllkherknisifkreqka 325
Cdd:cd15012  174 VWYLIPLLIMTVLYSKISIVLWKS--------------SSIEARRKVVRL------------------------------ 209
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966963638 326 attLGIIVGAFTVCWLPFFL----LSTARPFICGTSCSCI--PLwverTFLWLgYANSLINPFIYAFFNRDLR 392
Cdd:cd15012  210 ---LVAVVVSFALCNLPYHArkmwQYWSEPYRCDSNWNALltPL----TFLVL-YFNSAVNPLLYAFLSKRFR 274
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
98-392 5.04e-17

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 80.51  E-value: 5.04e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIgGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15206   17 GNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLL-RNFIFGEVMCKLIPYFQAVSVSVSTFTLVAIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSaSITLPPLFGWAQNVNDDKVCL----------ISQDFgYTIYSTAVA 247
Cdd:cd15206   96 LERYFAICHPLKSRVWQTLSHAYKVIAGIWLLS-FLIMSPILVFSNLIPMSRPGGhkcrevwpneIAEQA-WYVFLDLML 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 248 FYIPMSVMLFMYyqiykaarksaakhkfpgfprvepdsvialnGIVKLQkeveecanlsrLLKHERKNISIfkreqkaat 327
Cdd:cd15206  174 LVIPGLVMSVAY-------------------------------GLISWT-----------LLEAKKRVIRM--------- 202
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966963638 328 tLGIIVGAFTVCWLPFFLLSTARPF--------ICGTSCSCIPLwvertflwLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15206  203 -LFVIVVEFFICWTPLYVINTWKAFdppsaaryVSSTTISLIQL--------LAYISSCVNPITYCFMNKRFR 266
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
99-392 5.80e-17

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 80.59  E-value: 5.80e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFC---NVFIAMdvmccTASIMTLCV 175
Cdd:cd15102   18 NLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAAYLANILLSGARTLRLSPAQWFLregSMFVAL-----SASVFSLLA 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 176 ISIDRYLGITRPLTYPVRQNGKCMAkMILSVWLLSASITLPPLFGWAqnvnddkvCLISQDFGYTI---YSTA------V 246
Cdd:cd15102   93 IAIERHLTMAKMKPYGASKTSRVLL-LIGACWLISLLLGGLPILGWN--------CLGALDACSTVlplYSKHyvlfcvT 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 247 AFYIPMSVMLFMYYQIYKAARksaAKHKFPGFPRVEPDSVialngivklqkeveecanlsRLLKherknisifkreqkaa 326
Cdd:cd15102  164 IFAGILAAIVALYARIYCLVR---ASGRKATRASASPRSL--------------------ALLK---------------- 204
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966963638 327 tTLGIIVGAFTVCWLPFFLLSTARPFicGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15102  205 -TVLIVLLVFIACWGPLFILLLLDVA--CPVKTCPILYKADWFLALAVLNSALNPIIYTLRSRELR 267
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
97-388 6.13e-17

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 80.93  E-value: 6.13e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMpfvsVTDLI---GGKWIFGHFFCNVFIAMDVMCCTASIMTL 173
Cdd:cd15197   16 VGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINV----LTDIIwriTVEWRAGDFACKVIRYLQVVVTYASTYVL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 174 CVISIDRYLGITRPLTYpvrQNGKCMAKMILSV-WLLSA--SITLPPLFGWAQNVNDDKVCLIS--QDFGYTIYSTAVA- 247
Cdd:cd15197   92 VALSIDRYDAICHPMNF---SQSGRQARVLICVaWILSAlfSIPMLIIFEKTGLSNGEVQCWILwpEPWYWKVYMTIVAf 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 248 --FYIPMSVMLFMYYQIYKAA-RKSAakhkfpgfprvepdsviALNGIVKLQKEV-EECANLSRLLkherknisIFKREQ 323
Cdd:cd15197  169 lvFFIPATIISICYIIIVRTIwKKSK-----------------IQVTINKAGLHDgSSRRSSSRGI--------IPRAKI 223
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 324 KAATTLGIIVGAFTVCWLPFFLLSTARPFicgtscSCIPLWVER----TFLW-LGYANSLINPFIYAFFN 388
Cdd:cd15197  224 KTIKMTFVIVTVFIICWSPYFVFDLLDVF------GLLPRSKTKiaaaTFIQsLAPLNSAINPLIYCLFS 287
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
99-392 6.36e-17

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 80.36  E-value: 6.36e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIfghffCNVFIAMDVMCCTASIMTLCVISI 178
Cdd:cd15962   18 NAIVVAIIFYTPTLRTPMFVLIGSLATADLLAGCGLILNFVFQYVIQSETI-----SLITVGFLVASFTASVSSLLAITV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 179 DRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWaQNVNDDKVCLISQDFGYT-IYSTAVAFYIPMSVMLF 257
Cdd:cd15962   93 DRYLSLYNALTYYSEKTVLGVHLMLAATWGVSLCLGLLPVLGW-NCLEERASCSIVRPLTKSnVTLLSASFFFIFILMLH 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 258 MYYQIYKAARKSAAKhkfpgfprvepdsvIALNgivklqkevEECANLSRLLKherknisifkrEQKAATTLGIIVGAFT 337
Cdd:cd15962  172 LYIKICKIVCRHAHQ--------------IALQ---------QHFLTASHYVA-----------TKKGVSTLAIILGTFG 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 966963638 338 VCWLPFFLLstarpfiCGTSCSCIP-LWVERTFLWLGYaNSLINPFIYAFFNRDLR 392
Cdd:cd15962  218 ASWLPFAIY-------CVVGDHEYPaVYTYATLLPATY-NSMINPIIYAYRNQEIQ 265
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
98-392 6.42e-17

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 80.57  E-value: 6.42e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFCNV--FIAMDVMCctASIMTLCV 175
Cdd:cd15193   17 GNLFVIALMSKRSTTKRLVDTFVLNLAVADL-VFVLTLPFWAASTALGGQWLFGEGLCKLssFIIAVNRC--SSILFLTG 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 176 ISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFgwAQNVNDDKVCLISQDF----GYTIYSTAVAFYIP 251
Cdd:cd15193   94 MSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGIPSLV--YRNLINESVCVEDSSSrffqGISLATLFLTFVLP 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 252 MSVMLFMYYQIYKaarksaakhkfpgfprvepdsvialngivklqkeveecanlsRLLKHERKNISIFKREQKAATTLGI 331
Cdd:cd15193  172 LIVILFCYCSILV------------------------------------------RLRRHFHGAKRTGRRRRNSLRIVFA 209
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966963638 332 IVGAFTVCWLPF--------FLLSTARPFICGTscSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15193  210 IVTAFVLSWLPFntlkavrlLLELGGGVLPCHT--TVAIRQGLTITACLAFVNSCVNPLIYSLLDRHFR 276
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
98-388 1.14e-16

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 79.39  E-value: 1.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd14964   15 GNLLVLLSLVRLRKRPRSTRLLLASLAACDL-LASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYGANLASIWTTLVLT 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGW----AQNVNDDKVCLISQDFGYTIYSTAVAFYIPMS 253
Cdd:cd14964   94 YHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKgaipRYNTLTGSCYLICTTIYLTWGFLLVSFLLPLV 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 254 VMLFMYYQIYKAARksaakhkfpgfprvepdsvialngivklqkeveecanlSRLLKHERKNISIFKREQKAATTLGIIV 333
Cdd:cd14964  174 AFLVIFSRIVLRLR--------------------------------------RRVRAIRSAASLNTDKNLKATKSLLILV 215
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 334 GAFTVCWLPFFLLstarpFICGTSCSCIPLWVERTFL--WLGYANSLINPFIYAFFN 388
Cdd:cd14964  216 ITFLLCWLPFSIV-----FILHALVAAGQGLNLLSILanLLAVLASTLNPFIYCLGN 267
7tmA_GPR185-like cd15960
G protein-coupled receptor 185 and similar proteins, member of the class A family of ...
99-392 1.18e-16

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.


Pssm-ID: 320626 [Multi-domain]  Cd Length: 268  Bit Score: 79.56  E-value: 1.18e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVA-VMPFVSVtdliggkWIFGHFFCNVFIA-MDVMCCTASIMTLCVI 176
Cdd:cd15960   18 NAIVIAILFYTPSLRAPMFILIGSLALADLLAGLGlIANFVAI-------YVMNSEAVTLCSAgLLLAAFSASVCSLLAI 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWaQNVNDDKVCLISQDFGYTIYST-AVAFYIPMSVM 255
Cdd:cd15960   91 TVDRYLSLYNALTYHTERTLTFTYGLLALLWLTCIGIGLLPAMGW-NCLRAPASCSVLRPVTKNNAAVlAVSFLLLFALM 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 256 LFMYYQIYKAARKSAAKhkfpgfprvepdsvIAlngivklqkeveecanlsrlLKHERKNISIFKREQKAATTLGIIVGA 335
Cdd:cd15960  170 MQLYLQICRIAFRHAQQ--------------IA--------------------VQHQFVNFCLASSTRKGVSTLSLILAT 215
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966963638 336 FTVCWLPFFLLS----TARPFICgTSCSCIPlwvertflwlGYANSLINPFIYAFFNRDLR 392
Cdd:cd15960  216 FAFCWVPFAVYSmvadSSYPMIY-TYYLVLP----------AACNSVINPIIYAFRNPDIQ 265
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
97-392 1.27e-16

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 79.79  E-value: 1.27e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFvKKLRQPSNYL-IVSLALADLsVAVAVMPFVSVTDLIGgKWIFGHFFCNVFIAMDVMCCTASIMTLCV 175
Cdd:cd14999   15 AGNVYTLVVMCL-SMRPRASMYVyILNLALADL-LYLLTIPFYVSTYFLK-KWYFGDVGCRLLFSLDFLTMHASIFTLTV 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 176 ISIDRYLGITRPLTYPVRQNGKCMAKMILsVWLLSASITLPPLFGWAQNVNDDK------VCLIS-QDFGYTIYSTA--- 245
Cdd:cd14999   92 MSTERYLAVVKPLDTVKRSKSYRKLLAGV-IWLLSLLLTLPMAIMIRLVTVEDKsggskrICLPTwSEESYKVYLTLlfs 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 246 VAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGfprvepdsvialngivklqkeveecanlsrllkheRKNisifKREQKA 325
Cdd:cd14999  171 TSIVIPGLVIGYLYIRLARKYWLSQAAASNSS-----------------------------------RKR----LPKQKV 211
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966963638 326 ATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLW-LGYANSLINPFIYAFFNRDLR 392
Cdd:cd14999  212 LKMIFTIVLVFWACFLPFWIWQLLYLYSPSLSLSPRTTTYVNYLLTcLTYSNSCINPFLYTLLTKNYK 279
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
98-392 1.33e-16

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 79.43  E-value: 1.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVvISVCFVKKLRQPSNYLIVSLALADLSVAVAVmPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15115   17 GNGLV-IWVAGLKMKRTVNTIWFLNLAVADLLCCLSL-PFSIAHLLLNGHWPYGRFLCKLLPSIIVLNMFASVFTLTAIS 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLpPLFGWAQNVNDDKVCLISQDF--GYTIYSTAVAFYIPMSVM 255
Cdd:cd15115   95 LDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCL-PVFIYRTTVTDGNHTRCGYDFlvAITITRAVFGFLLPLLII 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 256 LFMYYQIYKAARKSaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherkniSIFKREQKAATTLGIIVGA 335
Cdd:cd15115  174 AACYSFIAFRMQRG-----------------------------------------------RFAKSQSKTFRVIIAVVVA 206
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 336 FTVCWLPFFLLSTARPFICGTSCSCIPLWvERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15115  207 FFVCWAPYHIIGILSLYGDPPLSKVLMSW-DHLSIALAYANSCLNPVLYVFMGKDFK 262
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
99-392 2.78e-16

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 78.29  E-value: 2.78e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVmpfvsVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISI 178
Cdd:cd15100   18 NAIVVAIIFSTPSLRAPMFLLIGSLALADLLAGLGL-----ILHFVFRYCVYSEALSLVSVGLLVAAFSASVCSLLAITV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 179 DRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWaQNVNDDKVCLISQDFGYTIYST-AVAFYIPMSVMLF 257
Cdd:cd15100   93 DRYLSLYNALTYYSERTLTFTYVMLALLWTLALGLGLLPVLGW-NCLREGSSCSVVRPLTKNHLAVlAVAFLLVFALMLQ 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 258 MYYQIYKAARKSAAKhkfpgfprvepdsvialngiVKLQKEVEECANLSrllkHERKNISifkreqkaatTLGIIVGAFT 337
Cdd:cd15100  172 LYAQICRIVLRHAHQ--------------------IALQRHFLAPSHYV----ATRKGVS----------TLALILGTFA 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 966963638 338 VCWLPFFLLSTArpficgTSCSCIPLWVERTFLWLGYaNSLINPFIYAFFNRDLR 392
Cdd:cd15100  218 ACWIPFAVYCLL------GDGSSPALYTYATLLPATY-NSMINPIIYAFRNQDIQ 265
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
98-392 2.82e-16

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 78.72  E-value: 2.82e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVsVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15008   16 GNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFV-LLQFTSGRWTLGSAMCKLVRYFQYLTPGVQIYVLLSIC 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPV-RQNGKcmaKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTA---VAFYIPmS 253
Cdd:cd15008   95 VDRFYTIVYPLSFKVsREKAK---KMIAASWLFDAAFVSPALFFYGSNWGPHCNFFLPDSWDGAAYAIIhllVGFLVP-S 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 254 VMLFMYYQiykaarksaakhkfpgfprvepdsvialngivKLQKEVEECANLSRLLkheRKNISIFKREQKAATTLGIIV 333
Cdd:cd15008  171 ILIILFYQ--------------------------------KVIKYIWRIGTDGRTV---RRTMNIVPRTKVKTIKMFLML 215
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 334 GA-FTVCWLPFFLLSTARPFICGTSCSCIplwVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15008  216 NSmFLLSWLPFYVVQLWHPRESDYRQSSL---VFLAVTWISFSSSASKPTLYSVYNANFR 272
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
98-395 3.20e-16

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 78.35  E-value: 3.20e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAvMPFVSVtDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15971   17 GNTLVIYVILRYAKMKTVTNIYILNLAIADELFMLG-LPFLAI-QVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMS 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKcMAKMI-LSVWLLSASITLPPL-FGWAQNVNDDKVCLI-------SQDFGYTIYSTAVAF 248
Cdd:cd15971   95 IDRYLAVVHPIKSAKWRKPR-TAKMInMAVWGVSLLVILPIMiYAGVQTKHGRSSCTIiwpgessAWYTGFIIYTFILGF 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 249 YIPMSVMLFMYYQIYKAARKSaakhkfpgfprvepdsvialnGIvklqkeveecanlsRLLKHERKnisifKREQKAATT 328
Cdd:cd15971  174 FVPLTIICLCYLFIIIKVKSS---------------------GI--------------RVGSSKRK-----KSEKKVTRM 213
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966963638 329 LGIIVGAFTVCWLPFFLLStarpfICGTSCSCIPLWVERTF----LWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15971  214 VSIVVAVFVFCWLPFYIFN-----VSSVSVSISPTPGLKGMfdfvVVLSYANSCANPILYAFLSDNFKKSF 279
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
97-386 3.60e-16

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 78.25  E-value: 3.60e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15191   16 LGNSLVVCVFCHQSGPKTVASIYIFNLAVADL-LFLATLPLWATYYSYGYNWLFGSVMCKICGSLLTLNLFASIFFITCM 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNgkCMAKMI-LSVWLLSASITLPPL-FGWAQNVNDDKVCLISQDFGYTIYST---------- 244
Cdd:cd15191   95 SVDRYLAVVYPLRSQRRRS--WQARLVcLLVWVLACLSSLPTFyFRDTYYIEELGVNACIMAFPNEKYAQwsaglalmkn 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 245 AVAFYIPMSVMLFMYYQIYKAARKSaakhkfPGFprvepdsviALNGIvklqkeveecaNLSRLLKherknisifkreqk 324
Cdd:cd15191  173 TLGFLIPLIVIATCYFGIGRHLLKT------KGF---------GKNKQ-----------RRDKVLK-------------- 212
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 325 aatTLGIIVGAFTVCWLPF----FLLSTARpfiCGTSCSCIPLWVERT----FLWLGYANSLINPFIYAF 386
Cdd:cd15191  213 ---MVAAVVLAFLICWFPFhvltFLDALAR---MGVINNCWVITVIDKalpfAICLGFSNSCINPFLYCF 276
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
98-392 3.87e-16

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 78.31  E-value: 3.87e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADlSVAVAVMPFVSVTDLIGgKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15972   17 GNTLVIYVVLRYSASESVTNIYILNLALAD-ELFMLGLPFLAAQNALS-YWPFGSFMCRLVMTVDAINQFTSIFCLTVMS 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFgWAQNVNDDKVCLIS-------QDFGYTIYSTAVAFYI 250
Cdd:cd15972   95 VDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVI-FSGVPGGMGTCHIAwpepaqvWRAGFIIYTATLGFFC 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 251 PMSVMLFMYYQIYKAARKSAAKhkfpgfprvepdsvialngivklqkeveecanlSRLLKHERKnisifKREQKAATTLG 330
Cdd:cd15972  174 PLLVICLCYLLIVVKVRSSGRR---------------------------------VRATSTKRR-----GSERKVTRMVV 215
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966963638 331 IIVGAFTVCWLPFFLLSTARpFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15972  216 IVVAAFVLCWLPFYALNIVN-LVCPLPEEPSLFGLYFFVVVLSYANSCANPIIYGFLSDNFK 276
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
98-395 4.29e-16

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 78.07  E-value: 4.29e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADlSVAVAVMPFVSVTDLIGgKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15089   17 GNVLVMYGIVRYTKMKTATNIYIFNLALAD-ALATSTLPFQSAKYLME-TWPFGELLCKAVLSIDYYNMFTSIFTLTMMS 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPL-TYPVRQNGKcmAKMI-LSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGY------TIYSTAV--- 246
Cdd:cd15089   95 VDRYIAVCHPVkALDFRTPAK--AKLInICIWVLSSGVGVPIMVMAVTKTPRDGAVVCMLQFPSpswywdTVTKICVfif 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 247 AFYIPMSVMLFMYYQIykaarksaakhkfpgfprvepdsVIALNGIVKLQKEVEECANLSRLLKherknisifkreqkaa 326
Cdd:cd15089  173 AFVVPILVITVCYGLM-----------------------ILRLRSVRLLSGSKEKDRNLRRITR---------------- 213
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966963638 327 tTLGIIVGAFTVCWLP---FFLLSTA------RPFICGTSCSCIPlwvertflwLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15089  214 -MVLVVVAAFIICWTPihiFVIVWTLvdidrrNPLVVAALHLCIA---------LGYANSSLNPVLYAFLDENFKRCF 281
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
98-395 4.36e-16

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 77.97  E-value: 4.36e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVmPFVSVTDLIGgKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15973   17 GNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSV-PFLAASAALQ-HWPFGSAMCRTVLSVDGINMFTSVFCLTVLS 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTyPVRQNGKCMAKMI-LSVWLLSASITLP-PLF-GWAQNVNDDKVCLI-----SQDFGYTIYSTAVAFY 249
Cdd:cd15973   95 VDRYIAVVHPLR-AARYRRPTVAKMInICVWILSLLVISPiIIFaDTATRKGQAVACNLiwphpAWSAAFVIYTFLLGFL 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 250 IPMSVMLFMYYQIYKAARKSAAKHKFpgfprvepdsvialngivklqkeveecanlsrllkHERKnisifKREQKAATTL 329
Cdd:cd15973  174 LPVLAIGLCYILIIGKMRAVALKAGW-----------------------------------QQRR-----KSEKKITRMV 213
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966963638 330 GIIVGAFTVCWLPFFLLSTARPFICGTSCSciplwVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15973  214 LMVVTVFVICWMPFYVVQLLNLFLPRLDAT-----VNHASLILSYANSCANPILYGFLSDNFRRSF 274
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
98-395 4.94e-16

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 77.84  E-value: 4.94e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPS--NYLIVSLALADLSVAVAVMPFVSVTDLIGGkWIFGHFFCNV--FIAMDVMccTASIMTL 173
Cdd:cd15098   17 GNSLVITVLARVKPGKRRSttNVFILNLSIADLFFLLFCVPFQATIYSLPE-WVFGAFMCKFvhYFFTVSM--LVSIFTL 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 174 CVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQ----NVNDDKVCLIS-----QDFGYTIYST 244
Cdd:cd15098   94 VAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAVHQDLvhhwTASNQTFCWENwpekqQKPVYVVCTF 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 245 AVAFYIPMSVMLFMYYQIykaarksaakhkfpgfprvepdsviaLNGIVKLQKEVEECANLSRllkherknisifkreQK 324
Cdd:cd15098  174 VFGYLLPLLLITFCYAKV--------------------------LNHLHKKLKNMSKKSERSK---------------KK 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 325 AATTLGIIVGAFTVCWLPFFLlstarpficgtscscIPLWVE--------RTFLW------LGYANSLINPFIYAFFNRD 390
Cdd:cd15098  213 TAQTVLVVVVVFGISWLPHHI---------------IHLWVEfgdfpltqASFVLritahcLAYANSCVNPIIYAFLSEN 277

                 ....*
gi 966963638 391 LRTTY 395
Cdd:cd15098  278 FRKAY 282
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
97-269 5.33e-16

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 77.86  E-value: 5.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFVSVTDLIGgkWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15176   16 AGNSLVVAIYAYYKKLKTKTDVYILNLAVADL-LLLFTLPFWAADAVNG--WVLGTAMCKITSALYTMNFSCGMQFLACI 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRpltYPVRQN-GKCMAKMILSVWLLSASITLPPL-FGWAQNVNDDKVCLI--------SQDFGYTIYSTAV 246
Cdd:cd15176   93 SVDRYVAITK---ATSRQFtGKHCWIVCLCVWLLAILLSIPDLvFSTVRENSDRYRCLPvfppslvtSAKATIQILEVLL 169
                        170       180
                 ....*....|....*....|...
gi 966963638 247 AFYIPMSVMLFMYYQIYKAARKS 269
Cdd:cd15176  170 GFVLPFLVMVFCYSRVARALSRT 192
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
98-392 5.47e-16

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 77.93  E-value: 5.47e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYlIVSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDV--MCCTASIMTlcV 175
Cdd:cd15339   17 GNILVLFTIIRSRKKTVPDIY-VCNLAVADL-VHIIVMPFLIHQWARGGEWVFGSPLCTIITSLDTcnQFACSAIMT--A 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 176 ISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLP-----PLFGWAQNVNDDKVCLISQD--FGYTIYSTAVAF 248
Cdd:cd15339   93 MSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPvwvyaKVIKFRDGLESCAFNLTSPDdvLWYTLYQTITTF 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 249 YIPMSVMLFMY----YQIYKAARKSAAKHKF-PGFPRVEpdsvialngIVKLQKEVEecanlsrllkherknisifkreq 323
Cdd:cd15339  173 FFPLPLILICYililCYTWEMYRKNKKAGRYnTSIPRQR---------VMRLTKMVL----------------------- 220
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 324 kaattlgIIVGAFTVCWLPFFL-----LSTARP---FICGTSCSciplwvertfLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15339  221 -------VLVGVFLVSAAPYHViqlvnLSVSQPtlaFYVSYYLS----------ICLSYASSSINPFLYILLSGNFR 280
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
97-392 5.66e-16

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 78.45  E-value: 5.66e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15217   16 AGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIRNGSAWTYSVLSCKIVAFMAVLFCFHAAFMLFCI 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLF--GWAQNVNDDKVCLISQDfgYTIYSTAVAFYIPMSV 254
Cdd:cd15217   96 SVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAFPPVFdvGTYKFIREEDQCIFEHR--YFKANDTLGFMLMLAV 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 255 MLFMYYQIY------------------------------KAARKSAAKHKFPGFPRVE-PDSVIALngivklqKEVEECA 303
Cdd:cd15217  174 LIVATHIVYgklllfeyrhrkmkpvqmvpaisqnwtfhgPGATGQAAANWIAGFGRGPmPPTLLGI-------RQNAHTA 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 304 NlSRLLKHERknisiFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFIcgTSCScIPLWVERTFLWLGYANSLINPFI 383
Cdd:cd15217  247 N-RRLLGMEE-----FKAEKRLGRMFYVITLSFLVLWSPYIVACYWRVFV--KACS-IPHRYLSTAVWMSFAQAGVNPIV 317

                 ....*....
gi 966963638 384 YAFFNRDLR 392
Cdd:cd15217  318 CFLLNKDLK 326
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
97-386 7.16e-16

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 77.31  E-value: 7.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVaVMPFVSVTDLIGgkWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15178   16 PGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFAL-TLPFWAVSVVKG--WIFGTFMCKLVSLLQEANFYSGILLLACI 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPlTYPVRQNGKCMAKMILSVWLLSASITLPPLF---GWAQNVNDDKVCLISQDFGYT--------IYSTA 245
Cdd:cd15178   93 SVDRYLAIVHA-TRALTQKRHLVKFVCAGVWLLSLLLSLPALLnrdAFKPPNSGRTVCYENLGNESAdkwrvvlrILRHT 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 246 VAFYIPMSVMLFMYyqiykaarksaakhkfpGFprvepdsvialngivklqkeveecaNLSRLLK-HERknisifkREQK 324
Cdd:cd15178  172 LGFLLPLVVMLFCY-----------------GF-------------------------TIKTLLQtRSF-------QKHR 202
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966963638 325 AATTLGIIVGAFTVCWLPF--------FLLSTARPFICGTSCSciplwVERTFLW---LGYANSLINPFIYAF 386
Cdd:cd15178  203 AMRVIFAVVLAFLLCWLPYnvtvlidtLMRTKLITETCELRNH-----VDVALYVtqiLGFLHSCINPVLYAF 270
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
98-392 7.68e-16

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 77.62  E-value: 7.68e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGkWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15980   17 GNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIIAG-WPFGSTVCKMSGMVQGISVSASVFTLVAIA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYlgitRPLTYPVRQ--NGKCMAKMILSVWLLSASITLPPlfGWAQNVNDDKVCLISQDFG----------------- 238
Cdd:cd15980   96 VDRF----RCIVYPFKQklTISTAVVIIVIIWVLAIAIMCPS--AVMLHVQEEKNYRVVLGSQnktspvywcredwpnqe 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 239 ----YTIYSTAVAFYIPMSVMLFMYYQI----YKAARKSAAKHkfpgfprvepdsvialngivklqkeveecanlsrllk 310
Cdd:cd15980  170 mrkiYTTVLFANIYLAPLSLIVIMYARIgitlFKTAMPHTGKH------------------------------------- 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 311 HERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPF--ICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFN 388
Cdd:cd15980  213 NQEQRHVVSRKKQKVIKMLLIVALLFILSWLPLWTLMMLSDYanLSPNQLQIINIYIYPFAHWLAFFNSSVNPIIYGFFN 292

                 ....
gi 966963638 389 RDLR 392
Cdd:cd15980  293 ENFR 296
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
98-395 7.73e-16

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 77.20  E-value: 7.73e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGkWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15400   17 GNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFHNG-WALGEMHCKVSGFVMGLSVIGSIFNITGIA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVnDDKV--CLISQDFG--YTIYSTAVAFYIPMS 253
Cdd:cd15400   96 INRYCYICHSFAYDKLYSRWNTLLYVCLIWALTVVAIVPNFFVGSLEY-DPRIysCTFVQTASssYTIAVVVIHFIVPIT 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 254 VMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVialngivklqkeveecanlsrllkheRKNISIFkreqkaattlgIIV 333
Cdd:cd15400  175 VVSFCYLRIWVLVIQVRRKVKSESKPRLKPSDF--------------------------RNFLTMF-----------VVF 217
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966963638 334 GAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15400  218 VIFAICWAPLNLIGLAVAINPQEMAPKVPEWLFVVSYFMAYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_S1PR5_Edg8 cd15348
sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial ...
99-392 1.23e-15

sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320470 [Multi-domain]  Cd Length: 277  Bit Score: 76.79  E-value: 1.23e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCN---VFIAMdvmccTASIMTLCV 175
Cdd:cd15348   18 NLIVLLALWRNKKFHSPMFYLLGSLTLSDLLAGAAYAANILMSGANTLKLTPALWFLReggVFITL-----TASVFSLLA 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 176 ISIDRYLGITRPLTYPVRQNGKcMAKMILSVWLLSASITLPPLFGW--AQNVNDDKVCLISQDFGYTIYSTAVAFYIPMS 253
Cdd:cd15348   93 IAIERHITMVRMKPYPGDKRGR-MFLLIGAAWLVSILLGVLPILGWncLGNLDACSTVLPLYAKSYILFCITVFLAILAA 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 254 VMLfMYYQIYKAARKSAakHKFPGFPRVepdsvialngivklqkeveecanlSRLLKHERKNISIFKreqkaatTLGIIV 333
Cdd:cd15348  172 IVV-LYARIYRIVKANS--QRLGALPTR------------------------KGRARRSQKYLALLK-------TVTIVL 217
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966963638 334 GAFTVCWLPFFLLstarpFICGTSC---SCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15348  218 GTFVACWLPLFLL-----LLLDVSCpaqACPVLLKADYFLGLAMINSLLNPIIYTLTSRDMR 274
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
101-401 1.87e-15

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 76.44  E-value: 1.87e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 101 LVVISVCFvKKLRQPSNYLIVSLALADLSVAVaVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR 180
Cdd:cd15084   31 VIVVSIKY-KKLRSPLNYILVNLAVADLLVTL-FGSSVSFSNNIVGFFVFGKTMCEFEGFMVSLTGIVGLWSLAILAFER 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 181 YLGITRPL-TYPVRQNGKCMAkmILSVWLLSASITLPPLFGWAQNVNDDKVCLI--------SQDFGYTIYSTAVAFYIP 251
Cdd:cd15084  109 YLVICKPMgDFRFQQRHAVSG--CAFTWGWSLLWTSPPLFGWSSYVPEGLRTSCgpnwytggTNNNSYILALFVTCFALP 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 252 MSVMLFMYYQIYKAARKSAAKhkfpgfprvepdsvialngivklQKEVEECanlsrllkherknisifKREQKAATTLGI 331
Cdd:cd15084  187 LSTIIFSYSNLLLTLRAVAAQ-----------------------QKESETT-----------------QRAEKEVTRMVI 226
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966963638 332 -IVGAFTVCWLPF----FLLSTARPFICGTSCSCIPLWVERTflwlgyaNSLINPFIYAFFNRDLRTTYRSLLQC 401
Cdd:cd15084  227 aMVMAFLICWLPYatfaMVVATNKDVVIQPTLASLPSYFSKT-------ATVYNPIIYVFMNKQFRSCLLELLCC 294
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
98-395 2.09e-15

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 75.96  E-value: 2.09e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVmPFVSVTDLIGgKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15093   17 GNSLVIYVVLRYAKMKTVTNIYILNLAIADELFMLGL-PFLAASNALR-HWPFGSVLCRLVLSVDGINMFTSIFCLTVMS 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTyPVRQNGKCMAKMI-LSVWLLSASITLPPLF--GWAQNVNDDKVCLISQ-------DFGYTIYSTAVA 247
Cdd:cd15093   95 VDRYLAVVHPIK-SARWRRPRVAKVVnLAVWVASLLVILPVVVfaGTRENQDGSSACNMQWpepaaawSAGFIIYTFVLG 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 248 FYIPMSVMLFMYYQIYKAARKSAAKhkfPGFPRvepdsvialngivklqkeveecanlsrllkheRKnisifKREQKAAT 327
Cdd:cd15093  174 FLLPLLIICLCYLLIVIKVKSAGLR---AGWQQ--------------------------------RK-----RSERKVTR 213
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966963638 328 TLGIIVGAFTVCWLPFFLLSTARPFiCGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15093  214 MVVMVVVVFVICWLPFYVLQLVNVF-VQLPETPALVGVYHFVVILSYANSCANPILYGFLSDNFKKSF 280
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
98-392 2.45e-15

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 75.73  E-value: 2.45e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVavmpFVSVTDLIggkWIFGHFF------CNVFIAMDVMCCTASIM 171
Cdd:cd15196   17 GNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVAL----FNVLPQLI---WDITYRFyggdllCRLVKYLQVVGMYASSY 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 172 TLCVISIDRYLGITRPLTYpVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFG-------YTIYST 244
Cdd:cd15196   90 VLVATAIDRYIAICHPLSS-HRWTSRRVHLMVAIAWVLSLLLSIPQLFIFSYQEVGSGVYDCWATFEppwglraYITWFT 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 245 AVAFYIPMSVMLFMYYQIYKAARKSAAKhkfpgfprvepdsvialngIVKLqkeveecanlsrllkherknisifkreqk 324
Cdd:cd15196  169 VAVFVVPLIILAFCYGRICYVVWRAKIK-------------------TVKL----------------------------- 200
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966963638 325 aatTLgIIVGAFTVCWLPFFLLSTAR-----PFICGTSCSCIPLwvertflwLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15196  201 ---TL-VVVACYIVCWTPFFVVQMWAawdptAPIEGPAFVIIML--------LASLNSCTNPWIYLAFSGNLR 261
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
97-392 4.12e-15

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 74.79  E-value: 4.12e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSnyLIVSLALADLSVAVAVMPF--VSVTDLIGGKwIFGHFFCNVFIAMDVMCCTASIMTLC 174
Cdd:cd15220   15 VGNTAVMVVIAKTPHLRKFA--FVCHLCVVDLLAALLLMPLgiLSSSPFFLGV-VFGEAECRVYIFLSVCLVSASILTIS 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 175 VISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGW----AQNVNDDKVCLISQDFG-----YTIYSTA 245
Cdd:cd15220   92 AISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVLGWpsygGPAPIAARHCSLHWSHSghrgvFVVLFAL 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 246 VAFYIPMSVMLFMYYQIYKAarksaakhkFPGfprvepdsvialngivklqkeveecanlsrllkherknisifkreQKA 325
Cdd:cd15220  172 VCFLLPLLLILVVYCGVFKV---------FGG---------------------------------------------GKA 197
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 326 ATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCsciPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15220  198 ALTLAAIVGQFLCCWLPYFAFHLYSALAASPVS---GGEAEEVVTWLAYSCFAVNPFFYGLLNRQIR 261
7tmA_GPR3 cd15963
G protein-coupled receptor 3, member of the class A family of seven-transmembrane G ...
99-392 4.19e-15

G protein-coupled receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320629 [Multi-domain]  Cd Length: 268  Bit Score: 74.92  E-value: 4.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVA-VMPFVSVTdliggkWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15963   18 NAIVVAVIFYTPAFRAPMFLLIGSLATADLLAGLGlILHFAFVY------CIQSAPVNLVTVGLLAPSFTASVSSLLAIT 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWaQNVNDDKVCLISQDFGYT-IYSTAVAFYIPMSVML 256
Cdd:cd15963   92 IDRYLSLYNALTYYSERTVTRTYIMLILTWGASLCLGLLPVVGW-NCLKDPSTCSVVKPLTKNhLVILSISFFMVFALML 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 257 fmyyQIYKAARKSAAKHkfpgfprvepdsvialngivklqkeveecANLSRLLKHERKNiSIFKREQKAATTLGIIVGAF 336
Cdd:cd15963  171 ----QLYAQICRIVCRH-----------------------------AHQIALQRHFLPT-SHYVTTRKGIATLAVILGTF 216
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 966963638 337 TVCWLPFFLLSTARPFicgtscSCIPLWVERTFLWLGYaNSLINPFIYAFFNRDLR 392
Cdd:cd15963  217 ASCWLPFAVYCLLGDY------TYPALYTYATLLPATY-NSMINPIIYAFRNQEIQ 265
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
101-392 6.25e-15

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 74.83  E-value: 6.25e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 101 LVVISVCF-VKKLRQPSNYLIVSLALADLSVAvAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISID 179
Cdd:cd15082   32 FAVMLVTFrFKQLRQPLNYIIVNLSVADFLVS-LTGGTISFLTNARGYFFLGVWACVLEGFAVTFFGIVALWSLAVLAFE 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 180 RYLGITRPLTyPVRQNGKCMAKMILSVWLLSASITLPPLFGWaqnvNDDKVCLIS------------QDFGYTIYSTAVA 247
Cdd:cd15082  111 RFFVICRPLG-NIRLQGKHAALGLLFVWTFSFIWTIPPVLGW----SSYTVSKIGttcepnwysgnmHDHTYIITFFTTC 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 248 FYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRvepdsvialngivklqkeveecanlsrllkherknisifKREQKAAT 327
Cdd:cd15082  186 FILPLGVIFVSYGKLLQKLRKVSNTQGRLGNAR---------------------------------------KPERQVTR 226
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966963638 328 TLGIIVGAFTVCWLP---FFLLSTARPFI-CGTSCSCIPLWVERTflwlgyaNSLINPFIYAFFNRDLR 392
Cdd:cd15082  227 MVVVMIVAFMVCWTPyaaFSILVTAHPTIhLDPRLAAIPAFFSKT-------AAVYNPIIYVFMNKQFR 288
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
97-395 6.27e-15

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 74.84  E-value: 6.27e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAvMPFVSVTDLIGgKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15974   16 SGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFMLG-LPFLATQNAIS-YWPFGSFLCRLVMTVDGVNQFTSIFCLTVM 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTyPVRQNGKCMAKMI-LSVWLLSASITLpPLFGWAQNVNDDKVCLIS-------QDFGYTIYSTAVAF 248
Cdd:cd15974   94 SIDRYLAVVHPIK-STKWRRPRVAKLInATVWTLSFLVVL-PVIIFSDVQPDLNTCNISwpepvsvWSTAFIIYTAVLGF 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 249 YIPMSVMLFMYYQIYKAARKSAAkhkfpgfprvepdsvialngivklqkeveecanlsRLLKHERKnisifKREQKAATT 328
Cdd:cd15974  172 FGPLLVICLCYLLIVIKVKSSGL-----------------------------------RVGSTKRR-----KSERKVTRM 211
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 329 LGIIVGAFTVCWLPFFLLSTARpFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15974  212 VVIIVVVFVFCWLPFYMLNIVN-LIVILPEEPAFVGVYFFVVVLSYANSCANPILYGFLSDNFKQSF 277
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
98-383 8.69e-15

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 74.38  E-value: 8.69e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVsVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd14977   17 GNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLN-AYNLLTKDWLFGDVMCKLVPFIQVTSLGVTVFSLCALS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGW------AQNVNDDKVCL--ISQDFGYTIYST----- 244
Cdd:cd14977   96 IDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAVLStvaresSLDNSSLTVCImkPSTPFAETYPKArswwl 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 245 -AVAFYIPMSVMLFMYYQIYKAARKSAAKHKfpgfprvepdsvialngivklqkeveecanlsrllkhERKNISIFKREQ 323
Cdd:cd14977  176 fGCYFCLPLAFTAVCYLLMARTLIRAAKEYT-------------------------------------RGTKKHMKQRRQ 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966963638 324 KAATTLGiIVGAFTVCWLPFFLLSTARPFIcgtscSCIPLWVERTFL--------WLGYANSLINPFI 383
Cdd:cd14977  219 LAKTVLC-LVLVFAFCWLPEHISNILRATL-----YNEVLIDTRSTLdildligqFLSFFNSCVNPIA 280
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
98-395 1.15e-14

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 73.81  E-value: 1.15e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAvAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd16003   17 GNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMA-AFNTLINFIYALHSEWYFGEAYCRFHNFFPITSVFASIYSMTAIA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTypVRQNGKCMAKMILSVWLLSASITLPP-LFGWAQNVNDDKVCLIS------QDFGYTIYSTAVAFYI 250
Cdd:cd16003   96 VDRYMAIIDPLK--PRLSATATKVVIGSIWILAFLLAFPQcLYSKTKVMPGRTLCFVAwpggpdQHFTYHIIVIVLVYCL 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 251 PMSVMLFMYyqiykaarksaakhkfpgfprvepdsviALNGIVKLQKEV--EECANLSRLLKHERKNISIfkreqkaatt 328
Cdd:cd16003  174 PLLVMGITY----------------------------TIVGITLWGGEIpgDTSDKYHEQLRAKRKVVKM---------- 215
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966963638 329 LGIIVGAFTVCWLPFFLLstarpFICGTSCSCIPLW--VERTFL---WLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd16003  216 MIIVVLTFAICWLPYHIY-----FIVTGLYQQLNRWkyIQQVYLasfWLAMSSTMYNPIIYCCLNKRFRAGF 282
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
98-394 1.54e-14

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 73.82  E-value: 1.54e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCfVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT-DLIGGKWIFGHF---FCNVFIAMDVMCCTASIMTL 173
Cdd:cd14978   17 GNILNLVVLT-RKSMRSSTNVYLAALAVSDILVLLSALPLFLLPyIADYSSSFLSYFyayFLPYIYPLANTFQTASVWLT 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 174 CVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGW-------AQNVNDDKVCLISQDFGYTIY---- 242
Cdd:cd14978   96 VALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYevvecenCNNNSYYYVIPTLLRQNETYLlkyy 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 243 ---STAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFpgfprvepdsvialngivklqkeveecanlsrLLKHERKNISIF 319
Cdd:cd14978  176 fwlYAIFVVLLPFILLLILNILLIRALRKSKKRRRL--------------------------------LRRRRRLLSRSQ 223
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966963638 320 KREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTT 394
Cdd:cd14978  224 RRERRTTIMLIAVVIVFLICNLPAGILNILEAIFGESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRT 298
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
98-274 2.61e-14

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 72.91  E-value: 2.61e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPS--NYLIVSLALADLSVaVAVMPFVsVTDLIGGKWIFGHFFCNvfiAMDVMCCT---ASIMT 172
Cdd:cd15122   17 GNGFIIWSILWKMKARGRSvtCILILNLAVADGAV-LLLTPFF-ITFLTRKTWPFGQAVCK---AVYYLCCLsmyASIFI 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 173 LCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFG---WAQNVNDDKVCLISQD------FGYTiYS 243
Cdd:cd15122   92 IGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALPAFVYrhvWKDEGMNDRICEPCHAsrghaiFHYT-FE 170
                        170       180       190
                 ....*....|....*....|....*....|.
gi 966963638 244 TAVAFYIPMSVMLFMYYQIYKAARKSAAKHK 274
Cdd:cd15122  171 TLVAFVLPFGVILFSYSVILVRLKGARFRRR 201
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
98-395 2.65e-14

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 72.97  E-value: 2.65e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15357   17 GNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFGMPLEVYEMWSNYPFLFGPVGCYFKTALFETVCFASILSVTTVS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPP------LFGWAQN---VNDDKVCLISQD---FGYTIYSTA 245
Cdd:cd15357   97 VERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFSIPNtsihgiKLQYFPNgtlIPDSATCTVVKPlwiYNLIIQITS 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 246 VAFYI-PMSVMLFMYYqiykaarksaakhkfpgfprvepdsviaLNGIvKLQKEveecanlsRLLKHERKNISIFKREQK 324
Cdd:cd15357  177 LLFYVlPMGVISVLYY----------------------------LMGL-KLRGD--------KSLEADEMNVNIQRPSRK 219
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 325 AAT-TLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLW-----VERTFLWLgyaNSLINPFIYAFFNRDLRTTY 395
Cdd:cd15357  220 SVTkMLFVLVLVFAICWAPFHVDRLFFSFVVEWTEPLANVFnlihvVSGVFFYL---SSAVNPIIYNLLSRRFRTAF 293
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
102-395 2.67e-14

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 73.03  E-value: 2.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 102 VVISVCF-VKKLRQPSNYLIVSLALADLSVAVAVMPfVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR 180
Cdd:cd15123   20 ILIKVFFkIKSMQTVPNIFITSLAFGDLLLLLTCVP-VDATRYIADTWLFGRIGCKLLSFIQLTSVGVSVFTLTVLSADR 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 181 YLGITRPLTypvRQNGKCMAKMILS---VWLLSASITLPPL-------FGWAQNVNDDKVCL---ISQDFGYTIYSTA-- 245
Cdd:cd15123   99 YRAIVKPLE---LQTSDAVLKTCCKagcVWIVSMLFAIPEAvfsdlysFRDPEKNTTFEACApypVSEKILQEIHSLLcf 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 246 VAFYI-PMSVMLFMYYQIYKAARKSAakhkfpgfprvepdsvialngivkLQKEVEECAnlsrllkHERKNISIFKReqk 324
Cdd:cd15123  176 LVFYIiPLSIISVYYFLIARTLYKST------------------------FNMPAEEHS-------HARKQIESRKR--- 221
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966963638 325 AATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFL--WLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15123  222 VAKTVLVLVALFAFCWLPNHILYLYRSFTYHTSVDSSAFHLIATIFsrVLAFSNSCVNPFALYWLSKSFRQHF 294
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
97-394 3.42e-14

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 72.49  E-value: 3.42e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFVSVTDLIGgkWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15179   16 VGNGLVILVMGYQKKSRTMTDKYRLHLSVADL-LFVLTLPFWAVDAAAN--WYFGNFLCKAVHVIYTVNLYSSVLILAFI 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPlTYPVRQNGKCMAKMI-LSVWLLSASITLPPL-FGWAQNVNDDKVClisqdfgYTIYSTAvAFYIPMSV 254
Cdd:cd15179   93 SLDRYLAIVHA-TNSQRPRKLLAEKVVyVGVWLPALLLTVPDLvFAKVSELDDRYIC-------DRIYPED-TFELWVVA 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 255 MLFmyyqiykaarksaaKHKFPGFprvepdsviALNGIVKLQKEVEECANLSRLLKHERKnisifkreqKAATTLGIIVG 334
Cdd:cd15179  164 FRF--------------QHILVGL---------VLPGLVILTCYCIIISKLSHSKGHQKR---------KALKTTVILIL 211
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966963638 335 AFTVCWLPFFLLSTARPFIC--GTSCSCIplWVERTFLW------LGYANSLINPFIYAFFNRDLRTT 394
Cdd:cd15179  212 AFFACWLPYYIGISIDTFMLleIIKQSCE--MEQTVHKWisiteaLAFFHCCLNPILYAFLGAKFKTS 277
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
99-394 3.78e-14

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 72.50  E-value: 3.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIgGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISI 178
Cdd:cd15075   18 NATVIIVTLRHKQLRQPLNYALVNLAVADLGTTVFGGLLSVVTNAV-GYFNLGRVGCVLEGFAVAFFGIAALCTVAVIAV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 179 DRYLGITRPLTYPVRQNGKCMAKMILSvWLLSASITLPPLFGWAQ--------NVNDDKVCLISQDFGYTIYSTAVAFYI 250
Cdd:cd15075   97 DRLFVVCKPLGTLTFQTRHALAGIASS-WLWSLIWNTPPLFGWGSyqlegvmtSCAPDWYSRDPVNVSYILCYFSFCFAI 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 251 PMSVMLFMYYQIYKAARKSAakhKFpgfprvepdsVIALNGIVKlqkeveecanlsrllkherknisifKREQKAATTLG 330
Cdd:cd15075  176 PFAIILVSYGYLLWTLRQVA---KL----------GVAEGGSTA-------------------------KAEVQVARMVV 217
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966963638 331 IIVGAFTVCWLPFFLLSTArpfICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTT 394
Cdd:cd15075  218 VMVMAFLLCWLPYAAFALT---VVSKPDVYINPLIATVPMYLAKSSTVYNPIIYIFMNKQFRDC 278
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
98-384 4.20e-14

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 72.15  E-value: 4.20e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNY---LIVSLALADLSVAVAvMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLC 174
Cdd:cd15338   17 GNSIVIYTIVKKSKFRCQQTVpdiFIFNLSIVDLLFLLG-MPFLIHQLLGNGVWHFGETMCTLITALDTNSQITSTYILT 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 175 VISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLS-ASITLPPLFGWAQNVNDDKV-CLI------SQDFGYTIYSTAV 246
Cdd:cd15338   96 VMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSlLSITPVWMYAGLMPLPDGSVgCALllpnpeTDTYWFTLYQFFL 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 247 AFYIPMSVMLFMYYQIykaarksaakhkfpgfprvepdsvialngivkLQKEVEECANLSRLlkherkniSIFKREQKAA 326
Cdd:cd15338  176 AFALPLVVICVVYFKI--------------------------------LQNMASTVAPLPQR--------SLRVRTKKVT 215
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966963638 327 TTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCipLWVERTFLWLGYANSLINPFIY 384
Cdd:cd15338  216 RMAVAICLAFFICWAPFYILQLAHLSIDRPSLAF--LYAYNVAISMGYANSCINPFLY 271
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
98-392 4.94e-14

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 72.20  E-value: 4.94e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFC---NVFIAMDVMCctaSIMTLC 174
Cdd:cd15194   17 GNAILMGALVFKRGVRRLIDIFISNLAASDF-IFLVTLPLWVDKEVVLGPWRSGSFLCkgsSYIISVNMYC---SVFLLT 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 175 VISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDK-----VCLISQDFGYTIYSTAVAFY 249
Cdd:cd15194   93 CMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPTLLSRELKKYEEKeycneDAGTPSKVIFSLVSLIVAFF 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 250 IPMSVMLFMYYQIYKaarksaakhkfpgfprvepdsvialngivKLqkeveeCANLSRLLKHERKnisifkrEQKAATTL 329
Cdd:cd15194  173 LPLLSILTCYCTIIW-----------------------------KL------CHHYQKSGKHQKK-------LRKSIKIV 210
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966963638 330 GIIVGAFTVCWLPFFLLStARPFICG--TSCSCIPLWVERTFLW----LGYANSLINPFIYAFFNRDLR 392
Cdd:cd15194  211 FIVVAAFVFSWMPFNLFK-ALAIASGlqVEVTCLPYTLAQLGMEvsapLAFANSCANPFIYYFFDRYIR 278
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
98-395 4.96e-14

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 72.24  E-value: 4.96e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPfVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15124   17 GNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAP-VDASRYLADEWLFGRVGCKLIPFIQLTSVGVSVFTLTALS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYpvrQNGKCMAKMILS---VWLLSASITLP-PLFGWAQNVNDDKVCLI---------SQDFGYTIYST 244
Cdd:cd15124   96 ADRYKAIVRPMDI---QASNALMKICLKaalIWILSMLLAIPeAVFSDLHPFYDKSTNKTfvscapyphSNELHPKIHSM 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 245 A--VAFY-IPMSVMLFMYYQIYKAARKSAAKhkfpgfprvepdsvIALNGIVKLQKEVEecanlSRllkherknisifkr 321
Cdd:cd15124  173 AsfLIFYvIPLSIISVYYYFIAKNLIRSAYN--------------LPVEGNVHVRRQIE-----SR-------------- 219
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966963638 322 eQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFL-WLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15124  220 -KRLAKTVLVFVGLFAFCWLPNHIIYLYRSYHYSEVDTSMLHFVSSICArILAFTNSCVNPFALYLLSKSFRKQF 293
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
98-395 6.49e-14

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 71.73  E-value: 6.49e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd14971   17 GNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPF-TATIYPLPGWVFGDFMCKFVHYFQQVSMHASIFTLVAMS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQ-NVNDDKVCLISQDF-------GYTIYSTAVAFY 249
Cdd:cd14971   96 LDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLALHRLrNYTPGNRTVCSEAWpsrahrrAFALCTFLFGYL 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 250 IPMSVMLFMYYQIYKaarksaakhkfpgfprvepdsvialngivklqkeveecaNLSRLLKHERKNISIFKREQKAATTL 329
Cdd:cd14971  176 LPLLLICVCYAAMLR---------------------------------------HLWRVAVRPVLSEGSRRAKRKVTRLV 216
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966963638 330 GIIVGAFTVCWLP---FFLLSTARPFICGTSCSCIPLWVErtflWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd14971  217 LVVVVLFAACWGPihaILLLVALGPFPLTYATYALRIWAH----CLAYSNSAVNPVLYAFLSEHFRKAF 281
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
97-392 8.46e-14

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 71.18  E-value: 8.46e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKlRQPSNYLIVSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFC--NVFIAMDVMCCtaSIMTLC 174
Cdd:cd14974   16 PGNGLVIWVAGFKMK-RTVNTVWFLNLALADF-LFCLFLPFLIVYIAMGHHWPFGSVLCklNSFVISLNMFA--SVFLLT 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 175 VISIDRYLGITRPLTYpvrQNGK--CMAKMI-LSVWLLSASITLPPLFGW-AQNVNDDKVCLISQDFGYTIYSTA----- 245
Cdd:cd14974   92 AISLDRCLLVLHPVWA---QNHRtvRLASVVcVGIWILALVLSVPYFVFRdTVTHHNGRSCNLTCVEDYDLRRSRhkalt 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 246 -----VAFYIPMSVMLFMYyqiykaarksaakhkfpgfprvepdSVIAlngiVKLQKeveecanlSRLLKHERKnisiFK 320
Cdd:cd14974  169 virflCGFLLPLLIIAICY-------------------------SVIA----VKLRR--------KRLAKSSKP----LR 207
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966963638 321 reqkaatTLGIIVGAFTVCWLPFFLLSTARpficgTSCSCIPLWVERTFLWLG----YANSLINPFIYAFFNRDLR 392
Cdd:cd14974  208 -------VLLAVVVAFFLCWLPYHVFALLE-----LVAAAGLPEVVLLGLPLAtglaYFNSCLNPILYVFMGQDFR 271
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
104-384 1.06e-13

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 71.21  E-value: 1.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 104 ISVCFV----KKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISID 179
Cdd:cd15134   19 LCTCIViarnRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWQQYPWVFGEVFCKLRAFLSEMSSYASVLTITAFSVE 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 180 RYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLP-----------PLFGWAQNVNDDKVCLISQD----FGYTIYST 244
Cdd:cd15134   99 RYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPfaiqtrivyleYPPTSGEALEESAFCAMLNEippiTPVFQLST 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 245 AVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLqkeveecanlsrllkherknisifkreqk 324
Cdd:cd15134  179 FLFFIIPMIAIIVLYVLIGLQLRRSTLLRRGQRSVSGGRRSSQSRRTVLRM----------------------------- 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966963638 325 aattLGIIVGAFTVCWLPFFLlstARPFICGTSCSCIPLWVERTFLW-----LGYANSLINPFIY 384
Cdd:cd15134  230 ----LVAVVVAFFICWAPFHA---QRLLTVYAKNMTPPYLFINRILFyisgvLYYVSSTVNPILY 287
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
110-393 1.17e-13

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 71.02  E-value: 1.17e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 110 KKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLiGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLT 189
Cdd:cd15080   29 KKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSM-HGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMS 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 190 -YPVRQNGKCMAkmILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDF----------GYTIYSTAVAFYIPMSVMLFM 258
Cdd:cd15080  108 nFRFGENHAIMG--VAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYytlkpevnneSFVIYMFVVHFTIPLIVIFFC 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 259 YYQIYKAARKSAAKhkfpgfprvepdsvialngivklQKEVEecanlsrllkherkniSIFKREQKAATTLGIIVGAFTV 338
Cdd:cd15080  186 YGRLVCTVKEAAAQ-----------------------QQESA----------------TTQKAEKEVTRMVIIMVIAFLI 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966963638 339 CWLPF----FLLSTARPFICGTSCSCIPLWVERTflwlgyaNSLINPFIYAFFNRDLRT 393
Cdd:cd15080  227 CWVPYasvaFYIFTHQGSDFGPIFMTIPAFFAKS-------SAVYNPVIYILMNKQFRN 278
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
97-392 1.28e-13

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 70.81  E-value: 1.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFC--NVFIAMDVMCCtaSIMTLC 174
Cdd:cd15168   16 LLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDL-LYLLSLPFLIYYYANGDHWIFGDFMCklVRFLFYFNLYG--SILFLT 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 175 VISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFgWAQNVNDDK--VCL---ISQDFG-YTIYS---TA 245
Cdd:cd15168   93 CISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILF-FATTGRKNNrtTCYdttSPEELNdYVIYSmvlTG 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 246 VAFYIPMSVMLFMYYqiykaarksaakhkfpgfprvepdsVIALNGIVKLQKEVEECanlsrllkherknisifkREQKA 325
Cdd:cd15168  172 LGFLLPLLIILACYG-------------------------LIVRALIRKLGEGVTSA------------------LRRKS 208
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966963638 326 ATTLGIIVGAFTVCWLPFFLLSTARPFI---CGTSCSCIPLWVERTFLW---LGYANSLINPFIYAFFNRDLR 392
Cdd:cd15168  209 IRLVIIVLALFAVCFLPFHVTRTINLAArllSGTASCATLNGIYVAYKVtrpLASLNSCLNPLLYFLAGDKFR 281
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
98-274 1.78e-13

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 70.18  E-value: 1.78e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFVSVTDLIGgkWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15173   17 GNSLVIVIYIFYEKLRTLTDIFLVNLAVADL-LFLCTLPFWAYSAAHE--WIFGTVMCKITNGLYTINLYSSMLILTCIT 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGK--CMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT-----IYSTAVAFYI 250
Cdd:cd15173   94 VDRFIVIVQATKAHNCHAKKmrWGKVVCTLVWVISLLLSLPQFIYSEVRNLSSKICSMVYPPDAIevvvnIIQMTVGFFL 173
                        170       180
                 ....*....|....*....|....*.
gi 966963638 251 PMSVMLFMYYQIYKAA--RKSAAKHK 274
Cdd:cd15173  174 PLLAMIICYSVIIKTLlhAKGFQKHK 199
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
99-395 1.93e-13

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 69.97  E-value: 1.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWI-----FGHFFCNVFIAMDVMCCTASIMTL 173
Cdd:cd15354   18 NILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHLviedaFVRHIDNVFDSLICISVVASMCSL 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 174 CVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLpplfgwaqnvnddkVCLISQDFGYTIYSTAVAFYIPMS 253
Cdd:cd15354   98 LAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIWTFCTGCGI--------------IFILYSESTYVIICLITMFFAMLF 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 254 VMLFMYYQIYKAARKSAAK-HKFPGFPRVepdsvialngivklqkeveecanlsrllkHERKNIsifkreqKAATTLGII 332
Cdd:cd15354  164 LMVSLYIHMFLLARTHVKRiAALPGYNSV-----------------------------RQRTSM-------KGAVTLTIL 207
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966963638 333 VGAFTVCWLPFFL-----LSTARPFICGTSCSCIPLwvertFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15354  208 LGIFIVCWAPFFLhlilmISCPQNLYCVCFMSHFNM-----YLILIMCNSVIDPLIYAFRSQEMRKTF 270
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
98-393 1.99e-13

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 70.11  E-value: 1.99e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLvviSVCFVKKLRQPSNYLIV---SLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLC 174
Cdd:cd15160   17 ANCL---ALWVLYLQIKKENVLGVyllNLSLSDL-LYILTLPLWIDYTANHHNWTFGPLSCKVVGFFFYTNIYASIGFLC 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 175 VISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPL-----FGWAQNVND--DKVCLISQDFGYTIYSTAVA 247
Cdd:cd15160   93 CIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELGTHSVFLghdelFRDEPNHTLcyEKYPMEGWQASYNYARFLVG 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 248 FYIPMSVMLFMYYQIYKAARKSAAkhkfpgfprvepdsvialngivklqkeveecanlsrLLKHERKNIsifkreQKAAT 327
Cdd:cd15160  173 FLIPLSLILFFYRRVLRAVRQSPS------------------------------------LEREEKRKI------IGLLL 210
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966963638 328 TLGIIvgaFTVCWLPFFLLSTARPFI-CGTSCSCipLWVERTF------LWLGYANSLINPFIYAFFNRDLRT 393
Cdd:cd15160  211 SIVVI---FLLCFLPYHVVLLVRSVIeLVQNGLC--GFEKRVFtayqisLCLTSLNCVADPILYIFVTEDVRQ 278
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
99-389 2.53e-13

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 69.77  E-value: 2.53e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISI 178
Cdd:cd15086   18 NLLVLVLFCKYKVLRSPINLLLLNISLSDLLVCVLGTPF-SFAASTQGRWLIGEHGCRWYGFANSLFGIVSLISLAVLSY 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 179 DRYLGITRPLTYPVRQNGKCMAKMILSvWLLSASITLPPLFGWAQNVNDDKVCLISQDfgYTIYSTAVAFYI-------- 250
Cdd:cd15086   97 ERYCTLLRPTEADVSDYRKAWLGVGGS-WLYSLLWTLPPLLGWSSYGPEGPGTTCSVQ--WTSRSANSISYIiclfifcl 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 251 --PMSVMLFMYYQIYKAARKSAAKHKfpgfprvepdsvialngivklqkeveecaNLSRllkherknisifKREQKAATT 328
Cdd:cd15086  174 llPFLVMVYCYGRLLYAIKQVGKINK-----------------------------STAR------------KREQHVLLM 212
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966963638 329 LGIIVGAFTVCWLPF---FLLST-ARPFICGTSCSCIPlwvertfLWLGYANSLINPFIYAFFNR 389
Cdd:cd15086  213 VVTMVICYLLCWLPYgvmALLATfGKPGLVTPVASIVP-------SILAKSSTVVNPIIYVFMNK 270
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
98-392 2.65e-13

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 69.98  E-value: 2.65e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPfVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15125   17 GNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVP-VDASRYFYEEWMFGTVGCKLIPVIQLTSVGVSVFTLTALS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLP-PLFGWAQNVNDDK-----VCL---ISQDFGYTIYSTA--- 245
Cdd:cd15125   96 ADRYKAIVNPMDIQTSSAVLRTCLKAIAIWVVSVLLAVPeAVFSEVAHIMPDDnttftACIpypQTDEMHPKIHSVLifl 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 246 VAFYIPMSVMLFMYYQIYKAARKSAakHKFPGfprvepdsvialngivklqkEVEEcanlsrllkHERKNISIFKReqkA 325
Cdd:cd15125  176 VYFLIPLAIISIYYYHIAKTLIKSA--HNIPG--------------------EYSE---------HSKRQMETRKR---L 221
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966963638 326 ATTLGIIVGAFTVCWLPFFLLSTARPF----ICGTSCSCIPLWVERTflwLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15125  222 AKIVLVFVGLFAFCWFPNHVLYMYRSFnyneIDSSLGHMIVTLVARV---LSFCNSCVNPFALYLLSESFR 289
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
98-293 4.11e-13

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 69.58  E-value: 4.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNY--LIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCV 175
Cdd:cd14981   17 GNLLALIVLARSSKSHKWSVFyrLVAGLAITDLLGILLTSPVVLAVYASNFEWDGGQPLCDYFGFMMSFFGLSSLLIVCA 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 176 ISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVN--DDKVC---LISQDFGYTIYS------- 243
Cdd:cd14981   97 MAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASLPLLGLGSYVLqyPGTWCfldFYSKNTGDAAYAylysilg 176
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 966963638 244 ---TAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIV 293
Cdd:cd14981  177 lliLLVTLLCNLLVIITLLRMRRRKKRHRRSRRSARRQKRNEIQMVVLLLAIT 229
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
98-395 4.40e-13

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 68.95  E-value: 4.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVA-VMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd14995   17 GNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVAaGLPNEIESLLGPDSWIYGYAGCLLITYLQYLGINASSLSITAF 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKvcliSQDFGYTIYSTAVAFYIPMSVM- 255
Cdd:cd14995   97 TIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSPWLFLLDLSIKHYG----DDIVVRCGYKVSRHYYLPIYLAd 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 256 LFMYYQIykaarksaakhkfpgfPRVepdSVIALNGIVklqkeveecanlSRLLKHERKNISifkreqkaaTTLGIIVGA 335
Cdd:cd14995  173 FVLFYVI----------------PLL---LAIVLYGLI------------GRILFSSRKQVT---------KMLAVVVVL 212
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966963638 336 FTVCWLPFFLLSTARPFIcgtSCSCIPLW---VERTFLwlgYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd14995  213 FALLWMPYRTLVVYNSFA---SPPYLDLWfllFCRTCI---YLNSAINPILYNLMSQKFRAAF 269
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
98-395 5.36e-13

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 69.01  E-value: 5.36e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAvMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd14991   17 GNVVALWIFCFHSRTWKANTVYLFNLVLADFLLLIC-LPFRIDYYLRGEHWIFGEAWCRVNLFMLSVNRSASIAFLTAVA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQdFGYTIYSTAV---------AF 248
Cdd:cd14991   96 LDRYFKVVHPHHRVNRMSVKAAAGVAGLLWALVLLLTLPLLLSTLLTVNSNKSSCHSF-SSYTKPSLSIrwhnalfllEF 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 249 YIPMSVMLFMYYQIYKAARKsaakhkfpgfpRVEPDsvialngivklqkeveecanlsrllKHerknisifKREQKAATT 328
Cdd:cd14991  175 FLPLGLIVFCSVRIACNLRI-----------RQSLG-------------------------KQ--------ARVQRAIRL 210
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966963638 329 LGIIVGAFTVCWLP-----FFLLSTARPFICGTSCSCIPLWveRTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd14991  211 VFLVVIVFVLCFLPsiiagLLALVFKNLGSCRCLNSVAQLF--HISLAFTYLNSALDPVIYCFSSPWFRNSL 280
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
99-395 5.56e-13

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 68.78  E-value: 5.56e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGH-FFCNVFIAMDVMCCT---ASIMTLC 174
Cdd:cd15353   18 NILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVITLLNGNDTDAQsFTVNIDNVIDSVICSsllASICSLL 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 175 VISIDRYLGITRPLTYPVRQNGKCMAKMILSVWllSASITLPPLFGWAQNVNDDKVCLISQdfgytiystavaFYIPMSV 254
Cdd:cd15353   98 SIAVDRYFTIFYALQYHNIMTVRRAGVIITCIW--TACTVSGVLFIIYSDSSVVIICLISM------------FFTMLAL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 255 MLFMYYQIYKAARKSAAKhkfpgfprvepdsVIALNGivklQKEVEECANLsrllkherknisifkreqKAATTLGIIVG 334
Cdd:cd15353  164 MASLYVHMFLLARLHIKR-------------IAVLPG----TGPIRQGANM------------------KGAITLTILLG 208
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966963638 335 AFTVCWLPFFLlstarPFICGTSCSCIPLWV-----ERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15353  209 VFVVCWAPFFL-----HLIFYISCPRNPYCVcfmshFNMYLILIMCNSVIDPLIYAFRSQELRKTF 269
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
98-259 6.69e-13

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 68.56  E-value: 6.69e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFCNV---FIAMDVMCctaSIMTLC 174
Cdd:cd15967   17 GNVWGLKSLLANWKKLGNINVFVLNLGLADL-LYLLTLPFLVVYYLKGRKWIFGQVFCKItrfCFNLNLYG---SIGFLT 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 175 VISIDRYLGItrplTYPVRQNGKCMA--KMILS--VWLLSASITLPPLFgWAQNVNDDKVCL--ISQDF-----GYTIYS 243
Cdd:cd15967   93 CISVYRYLAI----VHPMRVMGRITTthSVVISalVWLLVVIQSLPDLF-FSKTNSNGTKCFdtTFNDYlesylTYSLGW 167
                        170
                 ....*....|....*.
gi 966963638 244 TAVAFYIPMSVMLFMY 259
Cdd:cd15967  168 TVTGFVIPLLIILGCY 183
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
98-392 7.21e-13

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 68.74  E-value: 7.21e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIgGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15978   17 GNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLL-KDFIFGSAVCKTATYFMGISVSVSTFNLVAIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPplfgwaqnvnddkvclisqdfgYTIYSTAVAFYIPMSVMLF 257
Cdd:cd15978   96 LERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLP----------------------YPIYSNLVPFTRINNSTGN 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 258 MYYQIYKAARKSAAKHKFPGFprvepdSVIALNGIVKLQKEVEECANLSRllkherkNISIFKREQKAATTLGIIVGAFT 337
Cdd:cd15978  154 MCRLLWPNDVTQQSWYIFLLL------ILFLIPGIVMMTAYGLISLELYR-------GIKFLMAKKRVIRMLIVIVILFF 220
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966963638 338 VCWLPFFLLSTARPF--------ICGTSCSCIPLwvertflwLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15978  221 LCWTPIFSANAWRAFdtrsadrlLSGAPISFIHL--------LSYTSACVNPIIYCFMNKRFR 275
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
97-388 7.62e-13

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 68.67  E-value: 7.62e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAV-AVMPFV--SVTDLIGGKwifgHFFCNVFIAMDVMCCTASIMTL 173
Cdd:cd15386   16 AGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALfQVLPQLiwEITYRFQGP----DLLCRAVKYLQVLSMFASTYML 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 174 CVISIDRYLGITRPLTyPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLIS--QDFG-------YTIYST 244
Cdd:cd15386   92 IMMTVDRYIAVCHPLR-TLQQPSRQAYLMIGATWLLSCILSLPQVFIFSLREVDQGSGVLDcwADFGfpwgakaYITWTT 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 245 AVAFYIPMSVMLFMY----YQIYKAAR-KSAAKHKF--PGFPRVEPDSVIALNGIvklqkeveecanlsrllkhERKNIS 317
Cdd:cd15386  171 LSIFVLPVAILIVCYslicYEICKNLKgKTQTSRSEggGWRTQGMPSRVSSVRTI-------------------SRAKIR 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 318 IFKreqkaatTLGIIVGAFTVCWLPFFllstarpficgtSCSCIPLWVERT------------FLWLGYANSLINPFIYA 385
Cdd:cd15386  232 TVK-------MTFVIVLAYIACWAPFF------------SVQMWSVWDENApdedssdfaftiTMLLASLSSCCNPWIYM 292

                 ...
gi 966963638 386 FFN 388
Cdd:cd15386  293 FFS 295
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
97-388 8.69e-13

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 68.68  E-value: 8.69e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15198   16 AGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGGTALSQIIWELLGDRWMAGDVACRLLKLLQASARGASANLVVLL 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRqngkcMAKMILSVWLLSASITLPPLFGWAQNVNDDK------VCLISQDFG---------YTI 241
Cdd:cd15198   96 ALDRHQAIRAPLGQPLR-----AWKLAALGWLLALLLALPQAYVFRVDFPDDPasawpgHTLCRGIFAplprwhlqvYAT 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 242 YSTAVAFYIPMSVMLFMYYQIY-KAARKSAAkhkfpGFPRVEPDsvialngivKLQKEVEECANLSRLLKheRKNISIFK 320
Cdd:cd15198  171 YEAVVGFVAPVVILGVCYGRLLlKWWERANQ-----APGAKKPW---------KKPSKSHLRATAPSALP--RAKVKTLK 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966963638 321 reqkaaTTLgIIVGAFTVCWLPFFLLSTARPFicgTSCSCIPLWVERTFLWLGYANSLINPFIYAFFN 388
Cdd:cd15198  235 ------MTL-VIALLFVGCSLPYFIAELAAAF---GSGDWEPEKVAAALGVMAVANSATNPFVFLFFN 292
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
98-384 8.79e-13

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 67.94  E-value: 8.79e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTdLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15404   17 GNFVVCLMVYQKAAMRSAINILLASLAFADMMLAVLNMPFALVT-IITTRWIFGDAFCRVSAMFFWLFVMEGVAILLIIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRpltypvRQN--GKCMAKMILSV-WLLSASITLPPLFGWA--QNVNDDKVCLI--SQDFGYTIYS---TAVA 247
Cdd:cd15404   96 IDRFLIIVQ------KQDklNPYRAKVLIAVsWAVSFCVAFPLAVGSPdlQIPSRAPQCVFgyTTNPGYQAYViliMLIF 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 248 FYIPMSVMLFMYYQIYKAARKsaakhkfpgfprvepdsvialngivklqkeveecanlsrllkherknisiFKreQKAAT 327
Cdd:cd15404  170 FFIPFMVMLYSFMGILNTVRS--------------------------------------------------FK--TRAFT 197
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966963638 328 TLGIIVGAFTVCWLPFF---LLST-ARPFICGTSCSCIPLWvertFLWLGYANSLINPFIY 384
Cdd:cd15404  198 TILILFIVFTVCWAPFTtysLVATfNSHFYHKHNFFEISTW----LLWLCYLKSALNPLIY 254
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
99-395 9.78e-13

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 67.90  E-value: 9.78e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVA-VMPFVSVTDLIGGKWIFGHFFC----NVFIAMDVMCCTASIMTL 173
Cdd:cd15103   18 NILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSnALETIVIILLNNGYLVPRDSFEqhidNVIDSMICSSLLASICSL 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 174 CVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLpplfgwaqnvnddkVCLISQDFGYTIYSTAVAFYIPMS 253
Cdd:cd15103   98 LAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGI--------------LFIIYSDSVPVIICLISMFFAMLV 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 254 VMLFMYYQIYKAARKSAAKhkfpgfprvepdsVIALNGIVKLqkeveecanlsrllkHERKNIsifkreqKAATTLGIIV 333
Cdd:cd15103  164 LMASLYVHMFLLARSHVKK-------------IAALPGQRST---------------RQRANM-------KGAVTLTILL 208
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966963638 334 GAFTVCWLPFFLLSTARPFiCGTS--CSCIpLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15103  209 GVFIFCWAPFFLHLTLMIS-CPSNpyCACY-MSHFNVYLILIMCNSVIDPLIYAFRSQELRKTF 270
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
98-264 1.37e-12

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 67.86  E-value: 1.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFVSVTDliGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15172   17 GNSLVVITYAFYKRTKSMTDVYLLNMAIADI-LFVLTLPFWAVYE--AHQWIFGNFSCKLLRGIYAINFYSGMLLLACIS 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRpLTYPVRQNGKCMA--KMI-LSVWLLSASITLPPLF---GWAQNVNDDKVCLISQDFGYT---------IY 242
Cdd:cd15172   94 VDRYIAIVQ-ATKSFRLRSRTLAysKLIcAAVWLLAILISLPTFIfseVYDFGLEEQYVCEPKYPKNSTaimwkllvlSL 172
                        170       180
                 ....*....|....*....|..
gi 966963638 243 STAVAFYIPMSVMLFMYYQIYK 264
Cdd:cd15172  173 QVSLGFFIPLLVMIFCYSFIIK 194
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
97-264 1.81e-12

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 67.48  E-value: 1.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAvMPFVSVTdlIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15175   16 LGNGLVILTYIYFKRLKTMTDIYLLNLALADILFLLT-LPFWAAS--AAKKWVFGEEMCKAVYCLYKMSFFSGMLLLMCI 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITR-PLTYPVRQNGKCMAKMI-LSVWLLSASITLPPL-FGWAQNVNDDKVCLISQDFGYTIYST------AVA 247
Cdd:cd15175   93 SIDRYFAIVQaASAHRHRSRAVFISKVSsLGVWVLAFILSIPELlYSGVNNNDGNGTCSIFTNNKQTLSVKiqisqmVLG 172
                        170
                 ....*....|....*..
gi 966963638 248 FYIPMSVMLFMYYQIYK 264
Cdd:cd15175  173 FLVPLVVMSFCYSVIIK 189
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
98-395 1.86e-12

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 67.56  E-value: 1.86e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAV--AVMPFVSVTDLIggkWIFGHFFCNVFIAMDVMCCTASIMTLCV 175
Cdd:cd16004   17 GNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAfnTAFNFVYASHND---WYFGLEFCRFQNFFPITAMFVSIYSMTA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 176 ISIDRYLGITRPLTypVRQNGKCMAKMILSVWLLSASITLPPLFgWAQNVNDD--KVCLIS--QDFG------YTIYSTA 245
Cdd:cd16004   94 IAADRYMAIIHPFK--PRLSAGSTKVVIAGIWLVALALAFPQCF-YSTVTMDQgrTKCIVAwpGDSGgkhqltYHLAVIV 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 246 VAFYIPMSVMLFMYYQIykaarksaakhkfpgfprvepdsvialnGIVKLQKEVEECANLSRLLKHerknisiFKREQKA 325
Cdd:cd16004  171 LIYLLPLAVMFVTYSII----------------------------GITLWRSAVPGHQAHGAYHRQ-------LQAKKKF 215
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 326 ATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd16004  216 VKTMVVVVVTFAICWLPYHLYFILGSFNEDIYCQKYIQQVYLAIFWLAMSSTMYNPIIYCCLNQRFRSGF 285
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
99-395 1.91e-12

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 67.22  E-value: 1.91e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVA-VMPFVSVTDLIGGKWIFGHFFC----NVFIAMDVMCCTASIMTL 173
Cdd:cd15352   18 NILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSnSLETIMIAVLNSGYLVISDQFIqhmdNVFDSMICISLVASICNL 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 174 CVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLlsASITLPPLFGWAQNVNDDKVCLISQdfgytiystavaFYIPMS 253
Cdd:cd15352   98 LAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWV--VCIVCGIVFIVYSESKTVIVCLITM------------FFAMLV 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 254 VMLFMYYQIYKaarksaakhkfpgFPRVEPDSVIALNGIVKLQKEVEECanlsrllkherknisifkreQKAATTLGIIV 333
Cdd:cd15352  164 LMATLYVHMFL-------------FARLHVKRIAALPPAVDGAPQQRSC--------------------MKGAVTITILL 210
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 334 GAFTVCWLPFFLlstarPFICGTSCSCIPLWVE-----RTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15352  211 GVFIVCWAPFFL-----HLILIISCPHNPYCLCytshfNTYLVLIMCNSVIDPLIYAFRSLEMRKTF 272
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
98-393 2.00e-12

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 67.48  E-value: 2.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15381   17 ENAFVLIVFCLHKSSCTVAEIYLGNLAAADL-LLVCCLPFWAINISNGFNWPFGEFLCKSVNAVIYMNLYSSIYFLMMVS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPvRQNGKCMAKMI-LSVWLLSASITLPP-LFGWAQNVNDDKV--CLISQ-----DFGYTIYSTAVAF 248
Cdd:cd15381   96 IDRYLALVKTMSSG-RMRRPACAKLNcLIIWMFGLLMSTPMiVFRTVMYFPEYNItaCVLDYpsegwHVALNILLNVVGF 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 249 YIPMSVMLFMYYQIYKAARKsaakhkfpgfprvepdsvialngivklqkeveecaNLSRLLKHERKnisifkrEQKAATT 328
Cdd:cd15381  175 LIPLSIITFCSTQIIQVLRN-----------------------------------NKMQKFKEIQT-------ERKATVL 212
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 329 LGIIVGAFTVCWLPF---FLLSTARPFICGTSCSC--IPLWVERTFLWLGYANSLINPFIYAFFNRDLRT 393
Cdd:cd15381  213 VLAVLLMFFICWLPFhifTFLDTLHKLGLISGCRWedILDIGTQIATFLAYSNSCLNPLLYVIVGKHFRK 282
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
98-262 2.11e-12

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 67.05  E-value: 2.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFVsVTDLIGGKWIFGHFFC--NVFIAMDVMccTASIMTLCV 175
Cdd:cd15378   17 GNTIVILGYIFCLKNWKSSNIYLFNLSVSDL-AFLCTLPML-VYSYSNGQWLFGDFLCksNRYLLHANL--YSSILFLTF 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 176 ISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKV-CL---ISQDFGYT-IYS---TAVA 247
Cdd:cd15378   93 ISIDRYLLIKYPFREHILQKKRSAVAISLAIWVLVTLELLPILTFIGPNLKDNVTkCKdyaSSGDATNSlIYSlflTVTG 172
                        170
                 ....*....|....*
gi 966963638 248 FYIPMSVMLFMYYQI 262
Cdd:cd15378  173 FLIPLCVMCFFYYKI 187
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
101-392 2.14e-12

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 67.36  E-value: 2.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 101 LVVIS------VCFV----KKLRQPSNYLIVSLALADLSVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASI 170
Cdd:cd15389   10 IIVISlfgnslVCHVifknKRMHTATNLFIVNLAVSDILITLLNTPF-TLVRFVNSTWVFGKIMCHLSRFAQYCSVYVST 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 171 MTLCVISIDRYLGITRPLTYPVRqngKCMAKMILSV-WLLSASITLPplFGWAQNV------NDDKVCLISQDFGY---- 239
Cdd:cd15389   89 LTLTAIALDRHRVILHPLKPRIT---PCQGVVVIAIiWIMASCLSLP--HAIYQKLvefeysNERTRSRCLPSFPEpsdl 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 240 -----TIYSTAVAFYIPMSVMLFMYYQIykaARKsaakhkfpgfprvepdsvialngiVKLQKEVEEcANLSRLLKHERK 314
Cdd:cd15389  164 fwkylDLATFILQYVLPLLIIGVAYTRV---AKK------------------------LWLRNAIGD-VTTEQYVAQRRK 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 315 NisifkreQKAATTLGIIVGAFTVCWLP---FFLLSTARPFICGTScsciplwVERTFLWLGYANSLINPFIYAFFNRDL 391
Cdd:cd15389  216 K-------KKTIKMLMLVVLLFAICWLPlncYHVLLSSHPIRSNSA-------LFFAFHWLAMSSTCYNPFIYCWLNDSF 281

                 .
gi 966963638 392 R 392
Cdd:cd15389  282 R 282
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
98-392 2.33e-12

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 67.16  E-value: 2.33e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGkWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15981   17 GNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITG-WPFDNAMCKMSGLVQGMSVSASVFTLVAIA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYlgitRPLTYPVRQNGKCMAKM--ILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYS------------ 243
Cdd:cd15981   96 VERF----RCIVHPFRQKLTLRKAIvtIVIIWVLALIIMCPSAVTLTVTREEHHFMVDDYNNSYPLYScweawpdtemrk 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 244 --TAVAF----YIPMSVMLFMYYQIYKAARKSAAKhkfpgfprvepdsvialngivklqkeveecANLSRLLKHERKNIS 317
Cdd:cd15981  172 iyTTVLFshiyLAPLTLIVIMYARIAFKLFKSSAP------------------------------IRGSQGEEEEGRRVS 221
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 318 ifKREQKAATTLGIIVGAFTVCWLPFF--LLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15981  222 --KRKIKVINMLIIVALFFTLSWLPLWtlMLLTDYGHLSEDQLNLVTVYVFPFAHWLAFFNSSVNPIIYGYFNENFR 296
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
97-393 2.41e-12

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 67.14  E-value: 2.41e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQ--PSNYLIVSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLC 174
Cdd:cd14976   16 LGNLLVLYLLKSNKKLRQqsESNKFVFNLALTDL-IFVLTLPFWAVEYALDFVWPFGTAMCKVVRYVTKLNMYSSIFFLT 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 175 VISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLP-PLFGWAQ-NVNDDKVCLISqdFGYTIYSTAVAFYIPM 252
Cdd:cd14976   95 ALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPeAIFSTDTwSSVNHTLCLLR--FPKNSSVTRWYNWLGM 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 253 svmlfmyYQIYKAARksaakhkfpGFprVEPDSVIALNGIVklqkeveecanLSRLLkhERKNISIFKREQKAATTLGII 332
Cdd:cd14976  173 -------YQLQKVVL---------GF--FLPLGIITLSYLL-----------LLRFL--QRKRGGSKRRKSRVTKSVFIV 221
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966963638 333 VGAFTVCWLPFFLLST--------ARPFicGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRT 393
Cdd:cd14976  222 VLSFFICWLPNQALSLwsalikfdDVPF--SDAFFAFQTYAFPVAICLAHSNSCLNPVLYCLVRREFRD 288
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
98-382 2.82e-12

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 66.91  E-value: 2.82e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSvTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15927   17 GNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTS-TIYTLDSWPFGEFLCKLSEFLKDTSIGVSVFTLTALS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTypvRQNGKCMAKMIL---SVWLLSASITLPPLFG------WAQNVNDDKVCLI-SQDFGY------TI 241
Cdd:cd15927   96 ADRYFAIVNPMR---KHRSQATRRTLVtaaSIWIVSILLAIPEAIFshvvtfTLTDNQTIQICYPyPQELGPnypkimVL 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 242 YSTAVAFYIPMSVMLFMYYQIYKAARKSAakhkfpgfprvepdSVIALNGIVKLQKEVEecanlsrllkhERKNIsifkr 321
Cdd:cd15927  173 LRFLVYYLIPLLIIGVFYVLMARHLIRST--------------RNIGSGQNQAAQRQIE-----------ARKKV----- 222
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 322 eqkaATTLGIIVGAFTVCWLP---FFLLSTARPficgTSCSCIPLWverTFLW------LGYANSLINPF 382
Cdd:cd15927  223 ----AKTVLAFVVLFAVCWLPrhvFMLWFHFAP----NGLVDYNAF---WHVLkivgfcLSFINSCVNPV 281
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
98-392 3.55e-12

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 66.74  E-value: 3.55e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAvMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15132   17 GNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLILLC-LPFDLYRLWKSRPWIFGEFLCRLYHYISEGCTYATILHITALS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPV---RQNGKCMAKMILSVWLLSASITLpPLFGWAQNVN-----DDKVC------LISQDFGYTIYS 243
Cdd:cd15132   96 IERYLAICFPLRAKVlvtRRRVKCVIAALWAFALLSAGPFL-FLVGVEQDNNihpddFSRECkhtpyaVSSGLLGIMIWV 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 244 TAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGfprvepdsvialngivKLQKEveecanlsrllKHERKNISIfkreq 323
Cdd:cd15132  175 TTTYFFLPMLCLSFLYGFIGRKLWKSKNDLRGPN----------------AAARE-----------RSHRQTVRI----- 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966963638 324 kaattLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15132  223 -----LAVVVLAFIICWLPFHIGRILFANTEDYRTMMFSQYFNIVAMQLFYLSASINPILYNLISRKYR 286
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
97-392 6.00e-12

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 65.91  E-value: 6.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVvISVCFVKKLRQPSNYLIVSLALADLSVaVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15117   16 LGNGLV-IWVTGFRMTRTVTTVCFLNLAVADFAF-CLFLPFSVVYTALGFHWPFGWFLCKLYSTLVVFNLFASVFLLTLI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPL-FGWAQNVNDDKVCLISQDfgyTIYSTAVAFYIPMSVM 255
Cdd:cd15117   94 SLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSGPHLvFRDTRKENGCTHCYLNFD---PWNETAEDPVLWLETV 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 256 LFMYYQiykaarkSAAKHKFPGFprVEPDSVIALngivklqkeveeCANLSRLLKHERKNIsifkREQKAATTLGIIVGA 335
Cdd:cd15117  171 VQRLSA-------QVITRFVLGF--LVPLVIIGG------------CYGLIAARLWREGWV----HSSRPFRVLTAVVAA 225
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 336 FTVCWLPF---FLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15117  226 FFLCWFPFhlvSLLELVVILNQKEDLNPLLILLLPLSSSLACVNSCLNPLLYVFVGRDFR 285
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
98-387 7.11e-12

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 65.92  E-value: 7.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMP-----FVSVtdliggKWIFGHFFCNVFIAMDVMCCTASIMT 172
Cdd:cd15384   17 GNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPseaiwAYTV------AWLAGNTMCKLVKYLQVFGLYLSTYI 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 173 LCVISIDRYLGITRPLTyPVRQNGKCmAKMILSVWLLSASITLPPLFGW----AQNVNDDKVCLIS-------QDFGYTI 241
Cdd:cd15384   91 TVLISLDRCVAILYPMK-RNQAPERV-RRMVTVAWILSPIFSIPQAVIFhverGPFVEDFHQCVTYgfytaewQEQLYNM 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 242 YSTAVAFYIPMSVMLFMYYQIYKAARKSAAkhkfpgfprvepdsvialngivklQKEVEECANLSRLLKHERkniSIFKR 321
Cdd:cd15384  169 LSLVFMFPIPLVIMVTCYVLIFITLSKSSR------------------------DFQGLEIYTRNRGPNRQR---LFHKA 221
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 322 EQKAATTLGIIVGAFTVCWLPFFLLSTARPFICgtscsciPLWV-ERTFLWL---GYANSLINPFIYAFF 387
Cdd:cd15384  222 KVKSLRMSAVIVTAFILCWTPYYVIMIWFLFFN-------PYPLnDILFDVIfffGMSNSCVNPLIYGAF 284
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
97-274 7.18e-12

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 65.57  E-value: 7.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVaVMPFVSVTDLIGgkWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15177   16 VGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLL-TLPFAAAETLQG--WIFGNAMCKLIQGLYAINFYSGFLFLTCI 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITR-PLTYPVRQNGKCMAKMI-LSVWLLSASITLPPL-FGWAQNVNDDKVC-LISQDFGYTIYSTAVA----- 247
Cdd:cd15177   93 SVDRYVVIVRaTSAHRLRPKTLFYSVLTsLIVWLLSILFALPQLiYSRVENRSELSSCrMIFPEVVSRTVKGATAltqvv 172
                        170       180       190
                 ....*....|....*....|....*....|.
gi 966963638 248 --FYIPMSVMLFMYYQIYKA--ARKSAAKHK 274
Cdd:cd15177  173 lgFAIPLIVMAVCYAAIGRTllAARGWERHR 203
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
101-405 8.99e-12

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 65.96  E-value: 8.99e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 101 LVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR 180
Cdd:PHA03087  59 IIVIYVLTKTKIKTPMDIYLLNLAVSDL-LFVMTLPF-QIYYYILFQWSFGEFACKIVSGLYYIGFYNSMNFITVMSVDR 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 181 YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGW-AQNVNDDKVCLISQDFGYTIYSTAVAF-------YIPM 252
Cdd:PHA03087 137 YIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYtTKKDHETLICCMFYNNKTMNWKLFINFeiniigmLIPL 216
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 253 SVMLFMYYQIYkaarksaakhkfpgfprvepdsvIALngivklqkeveecanlsrllkherKNISIFKREQKAATTLGII 332
Cdd:PHA03087 217 TILLYCYSKIL-----------------------ITL------------------------KGINKSKKNKKAIKLVLII 249
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966963638 333 VGAFTVCWLPF---FLLSTARPFICGTSC---SCIPLWVERTFLwLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRN 405
Cdd:PHA03087 250 VILFVIFWLPFnvsVFVYSLHILHFKSGCkavKYIQYALHVTEI-ISLSHCCINPLIYAFVSEFFNKHKKKSLKLMFTS 327
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
99-394 1.29e-11

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 64.81  E-value: 1.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLsvavavmpFVSVTDLIGGKWIF----GHFFCNVFI------AMDVMCCTA 168
Cdd:cd15351   18 NILVVVAIAKNRNLHSPMYYFICCLAVSDM--------LVSVSNLIETLFMLllehGVLVCRAPMlqhmdnVIDTMICSS 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 169 ---SIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLlsASITLPPLFGWAQNVNDDKVCLIsqdfgytiysta 245
Cdd:cd15351   90 vvsSLSFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWL--ASTVSSTLFIVYYNSNAVILCLI------------ 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 246 vAFYIPMSV-MLFMYYQIYKAARKSAakhkfpgfprvepdsvialNGIVKLQKEVEECANLSRLlkherknisifkreqK 324
Cdd:cd15351  156 -VFFLFMLVlMLVLYIHMFILACRHS-------------------QSISSQQRRQCPHQQTASL---------------K 200
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966963638 325 AATTLGIIVGAFTVCWLPFFL------LSTARPFicgtsCSCIPLWVErTFLWLGYANSLINPFIYAFFNRDLRTT 394
Cdd:cd15351  201 GAITLTILLGIFFLCWGPFFLhltlivTCPTHPF-----CLCYFKYFN-LFLILIICNSIIDPLIYAFRSQELRKT 270
7tmA_LPAR2_Edg4 cd15342
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial ...
99-395 1.50e-11

lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320464 [Multi-domain]  Cd Length: 274  Bit Score: 64.43  E-value: 1.50e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTdligGKWIFGHFFCNVFIAMDVM--CCTASIMTLCVI 176
Cdd:cd15342   18 NLLVIAAIFINRRFHYPIYYLLGNLAAADLFAGVAYLFLMFHT----GPWTAKLSLYQWFLRQGLLdtSLTASVANLLAI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAkMILSVWLLSASITLPPLFGWaQNVNDDKVC-----LISQDF-GYTIYSTAVAFYI 250
Cdd:cd15342   94 AVERHQTIFTMQLHSKMSNQRVVI-LIFGIWMVALILGLIPAMGW-NCLCDLKRCstmapLYSRSYlVFWALSNLLTFLI 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 251 PMSVMLFMYYQIYKAARKSAAKHKFPgfprvepdsvialngivklqkeveecanlsrlLKHERKNISIFKreqkaatTLG 330
Cdd:cd15342  172 MVAVYTRIFIYVRRKSQRMSEHHSSH--------------------------------PRYRETVLGLMK-------TVV 212
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966963638 331 IIVGAFTVCWLPFFLLStarpFICGTSC-SCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15342  213 IILGAFVVCWTPGQVVL----LLDGLGCeSCNVLAYEKYFLLLAEINSLVNPIVYSYRDKEMRKTF 274
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
98-389 1.66e-11

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 64.57  E-value: 1.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVC-FVKKLRQPSNYLIVSLALADLSVAVAVMpFVSVTDLI--------GGKWiFGHFFCNVfiaMDVMCCTA 168
Cdd:cd14980   17 GNILVIIWHIsSKKKKKKVPKLLIINLAIADFLMGIYLL-IIAIADQYyrgryaqySEEW-LRSPPCLL---ACFLVSLS 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 169 SIM---TLCVISIDRYLGITRPLTYpvRQNGKCMAKMILS-VWLLSASITLPPLFGWAQNVNDDK------VCLISqDFG 238
Cdd:cd14980   92 SLMsvlMMLLITLDRYICIVYPFSN--KRLSYKSAKIILIlGWLFSIIFAAIPILYSINQPGDNRlygyssICMPS-NVS 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 239 YTIYSTAVAFYIPMSV-----MLFMYYQIYKAARKSAakhkfpgfprvepdsvialngivklqkeveecanlsrllKHER 313
Cdd:cd14980  169 NPYYRGWLIAYLLLTFiawiiICILYILIFISVRKSR---------------------------------------KSAR 209
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 314 KNISifKREQKAATTLGIIVGAFTVCWLPFFLLSTaRPFICGTSCSCIPL-WVERTFLWLgyaNSLINPFIYAFFNR 389
Cdd:cd14980  210 RSSS--KRDKRIAIRLALILITDLICWLPYYIVIF-SGLLTSTEIDIHVLqFIAILALPL---NSAINPYLYTLTTP 280
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
99-395 1.88e-11

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 64.51  E-value: 1.88e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVA-----VMPFVSVTDLIGGKWIFGHffCNVFIAMdvmccTASIMTL 173
Cdd:cd15346   18 NIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAytanlLLSGATTYKLTPTQWFLRE--GSMFVAL-----SASVFSL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 174 CVISIDRYLGItrpLTYPVRQNGKCMAKMIL--SVWLLSASITLPPLFGW--AQNVNDDKVCLISQDFGYTIYSTAVAFY 249
Cdd:cd15346   91 LAIAIERYITM---LKMKLHNGSNSFRSFLLisACWVISLILGGLPIMGWncISALSSCSTVLPLYHKHYILFCTTVFTL 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 250 IPMSVMLfMYYQIYKAARKSAAKHKFPgfprvepdsvialngivklqkeveecANLSRLLKHERKNISIFKreqkaatTL 329
Cdd:cd15346  168 LLLSIVI-LYCRIYSLVRTRSRRLTFR--------------------------KNIRKASRSSEKSMALLK-------TV 213
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966963638 330 GIIVGAFTVCWLPFFLLstarpFICGTSC---SCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15346  214 IIVLSVFIACWAPLFIL-----LLLDVGCkvkTCSILFKAEYFLVLAVLNSATNPIIYTLTNKEMRRAF 277
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
98-392 2.33e-11

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 64.12  E-value: 2.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAvAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd16002   17 GNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMS-AFNTVINFTYAIHNEWYYGLEYCKFHNFFPIAAVFASIYSMTAIA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTypVRQNGKCMAKMILSVWLLSASITLP--------PLFG-------WAQNVNDDkvclisQDFGYTIY 242
Cdd:cd16002   96 LDRYMAIIHPLQ--PRLSATATKVVICVIWVLAFLLAFPqgyysdteEMPGrvvcyveWPEHEERK------YETVYHVC 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 243 STAVAFYIPMSVMLFMYYqiykaarksaakhkfpgfprvepdsvialngIVKLQKEVEECANLSRLLKHERknisiFKRE 322
Cdd:cd16002  168 VTVLIYFLPLLVIGCAYT-------------------------------VVGITLWASEIPGDSSDRYHEQ-----VSAK 211
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 323 QKAATTLGIIVGAFTVCWLP---FFLLSTARPFicgtscsciplWVERTF--------LWLGYANSLINPFIYAFFNRDL 391
Cdd:cd16002  212 RKVVKMMIVVVCTFAICWLPyhiYFLLQYFHPE-----------LYEQKFiqqvylaiMWLAMSSTMYNPIIYCCLNDRF 280

                 .
gi 966963638 392 R 392
Cdd:cd16002  281 R 281
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
99-393 3.12e-11

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 63.69  E-value: 3.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAV--AVMPFVSVTDLIggkWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15077   18 NVLTIICTIKYKKLRSHLNYILVNLAVANLIVVCfgSTTAFYSFSQMY---FVLGPLACKIEGFTATLGGMVSLWSLAVV 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSvWLLSASITLPPLFGWAQNVNDDKVCLISQDF----------GYTIYSTAV 246
Cdd:cd15077   95 AFERFLVICKPLGNFTFRGTHAIIGCIAT-WVFGLAASLPPLFGWSRYIPEGLQCSCGPDWyttnnkwnneSYVMFLFCF 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 247 AFYIPMSVMLFMYYQIykaarksaakhkfpgfprvepdsVIALNGIVKLQKEveecanlsrllkherkNISIFKREQKAA 326
Cdd:cd15077  174 CFGVPLSIIVFSYGRL-----------------------LLTLRAVAKQQEQ----------------SASTQKAEREVT 214
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966963638 327 TTLGIIVGAFTVCWLPFFLLS----TARPFICGTSCSCIPLWVERtflwlgyANSLINPFIYAFFNRDLRT 393
Cdd:cd15077  215 KMVVVMVLGFLVCWLPYASFAlwvvTNRGEPFDLRLASIPSVFSK-------ASTVYNPVIYVFMNKQFRS 278
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
98-392 3.21e-11

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 63.60  E-value: 3.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVaVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15192   17 GNSLVVIVIYCYMKLKTVANIFLLNLALADLCF-LITLPLWAAYTAMEYHWPFGNFLCKIASALVSFNLYASVFLLTCLS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFG----WAQNVNdDKVCLISQD-------FGYTIYSTAV 246
Cdd:cd15192   96 IDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAIIHrdvfFIENTN-ITVCAFHYPsqnstllVGLGLMKNLL 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 247 AFYIPMSVMLFMYYQIYKAarksaakhkfpgfprvepdsvialngivkLQKEVEECANLSRllkherkNISIFKreqkaa 326
Cdd:cd15192  175 GFLIPFLIILTCYTLIGKA-----------------------------LKKAYEIQRNKPR-------NDEIFK------ 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 327 tTLGIIVGAFTVCWLPF----FL-----------------LSTARPF-ICgtscsciplwvertflwLGYANSLINPFIY 384
Cdd:cd15192  213 -MIMAVVLFFFFCWIPHqiftFLdvliqlkviqdchiadiVDTAMPFtIC-----------------IAYFNSCLNPILY 274

                 ....*...
gi 966963638 385 AFFNRDLR 392
Cdd:cd15192  275 GFVGKNFR 282
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
99-392 3.48e-11

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 63.68  E-value: 3.48e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLiGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISI 178
Cdd:cd15076   18 NAIVLFVTIKYKKLRQPLNYILVNISLAGFIFCIFSVFPVFVASA-QGYFFFGRTVCALEAFVGSLAGLVTGWSLAFLAF 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 179 DRYLGITRPLTyPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDF----------GYTIYSTAVAF 248
Cdd:cd15076   97 ERYIVICKPFG-NFRFGSKHALGAVVATWIIGIGVSLPPFFGWSRYIPEGLQCSCGPDWytvgtkyrseYYTWFLFIFCF 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 249 YIPMSVMLFMYYQIYKAARKSAAKhkfpgfprvepdsvialngivklQKEVEecanlsrllkherkniSIFKREQKAATT 328
Cdd:cd15076  176 IVPLSIIIFSYSQLLGALRAVAAQ-----------------------QQESA----------------STQKAEREVSRM 216
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966963638 329 LGIIVGAFTVCWLPFFLLS----TARPFICGTSCSCIPLWVERtflwlgyANSLINPFIYAFFNRDLR 392
Cdd:cd15076  217 VVVMVGSFCLCYVPYAALAmymvNNRDHGLDLRLVTIPAFFSK-------SSCVYNPIIYCFMNKQFR 277
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
98-274 3.71e-11

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 63.62  E-value: 3.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFVSVTDLIGgkWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15174   17 GNSLVVLIYTYYRRRKTMTDVYLLNLAIADL-LFLCTLPFWATAASSG--WVFGTFLCKVVNSMYKINFYSCMLLLTCIS 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCM-AKMI-LSVWLLSASITLPP-LFGWAQNVNDDKVCL------ISQDFGYTIYSTAV-- 246
Cdd:cd15174   94 VDRYIAIVQATKAHNSKNKRLLySKLVcFFVWLLSTILSLPEiLFSQSKEEESVTTCTmvypsnESNRFKVAVLALKVtv 173
                        170       180       190
                 ....*....|....*....|....*....|
gi 966963638 247 AFYIPMSVMLFMYYQIYKA--ARKSAAKHK 274
Cdd:cd15174  174 GFFLPFVVMVICYTLIIHTllQAKRFQKHK 203
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
98-395 4.07e-11

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 63.30  E-value: 4.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIgGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15399   17 GNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLL-DEWKFGAVLCHLVPYAQALAVHVSTVTLTVIA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYlgitRPLTYPVRQN-GKCMAKMILSV-WLLSASITLP-PLFGWAQNVN---DDKVCLISQDFGY------TIYSTA 245
Cdd:cd15399   96 LDRH----RCIVYHLESKiSKKISFLIIGLtWAASALLASPlAIFREYSVIEispDFKIQACSEKWPNgtlndgTIYSVS 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 246 ---VAFYIPMSVMLFMYYQIYkaarksaakhkfpgfprvepdsvialngiVKLQKEVEECANlsrllkherkNISIFKRE 322
Cdd:cd15399  172 mllIQYVLPLAIISYAYIRIW-----------------------------TKLKNHVSPGGG----------NDHYHQRR 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 323 QKAATTLGIIVGAFTVCWLPFFLLSTArpficgtscSCIPLWVER---------TFLWLGYANSLINPFIYAFFNRDLRT 393
Cdd:cd15399  213 RKTTKMLVCVVVVFAVSWLPFHAFQLA---------SDIDSKVLDlkeykliytIFHVIAMCSTFANPLLYGWMNNNYRT 283

                 ..
gi 966963638 394 TY 395
Cdd:cd15399  284 AF 285
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
97-392 4.31e-11

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 63.38  E-value: 4.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPS-NYLIVSLALADLSVaVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCV 175
Cdd:cd15926   16 VGNLLVLYLMKSKQGWKKSSiNLFVTSLAVTDFQF-VLTLPFWAVENALDFTWLFGKAMCKIVSYVTAMNMYASVFFLTA 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 176 ISIDRYLGITRPLTYPvRQNGKCMAK-MILSVWLLSASITLP-PLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMS 253
Cdd:cd15926   95 MSVARYHSVASALKSK-RRRGCCSAKwLCVLIWVLAILASLPnAIFSTTATVSNEELCLVKFPDNRGNAQFWLGLYHAQK 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 254 VMLfmyyqiykaarksaakhkfpGFprVEPDSVIALNGIVklqkeveecanLSRLLKHERKNISIFKREQKAATTLGIIV 333
Cdd:cd15926  174 VLL--------------------GF--LIPLGIISLCYLL-----------LVRFITDKNITGSSTKRRSKVTKSVTIVV 220
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966963638 334 GAFTVCWLPFFLLSTARPFIcgtSCSCIPLWVE----RTFLW-----LGYANSLINPFIYAFFNRDLR 392
Cdd:cd15926  221 LSFFLCWLPNQALTTWGILI---KLNVVHFSYEyfttQVYIFpitvcLAHSNSCLNPILYCLMRREFR 285
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
98-392 6.51e-11

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 62.81  E-value: 6.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIvSLALADLSVAVAVmPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15114   17 GNALVAWVTGFEAKRSVNAVWFL-NLAVADLLCCLSL-PILAVPIAQDGHWPFGAAACKLLPSLILLNMYASVLLLTAIS 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYpvrQN--GKCMAKMIL-SVWLLSASITLPplfgwaqnvnddkvclisqdfgYTIYSTAVAFYIPMSV 254
Cdd:cd15114   95 ADRCLLVLRPVWC---QNhrRARLAWIACgAAWLLALLLTVP----------------------SFIYRRIHQEHFPEKT 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 255 MLFMYYQIYKAARKSAAKHKFPGFPRVePDSVIALNGIVKLQKEVEECANLSRllKHERknisifkreqkaaTTLGIIVG 334
Cdd:cd15114  150 VCVVDYGGSTGVEWAVAIIRFLLGFLG-PLVVIASCHGVLLVRTWSRRRQKSR--RTLK-------------VVTAVVVG 213
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966963638 335 aFTVCWLPF----FLLSTARPficGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15114  214 -FFLCWTPYhvvgLIIAASAP---NSRLLANALKADPLTVSLAYINSCLNPIIYVVAGRGFR 271
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
113-276 9.62e-11

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 62.07  E-value: 9.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 113 RQPSNYLIVSLALADLSVAVaVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPV 192
Cdd:cd15372   31 RLPSTIFLINLAVADLLLIL-VLPFKISYHFLGNNWPFGEGLCRVVTAFFYGNMYCSVLLLMCISLDRYLAVVHPFFART 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 193 RQNGKCMAKMILSVWLLSASITLP--------PLFGWAQNVNDDKVCLISQD---FGYTIYSTAVAFYIPMSVMLFMYYQ 261
Cdd:cd15372  110 LRSRRFALCMCTAIWLIAAALTLPltlqrqsyPLERLNITLCHDVLPLDEQDtylFYYFACLAVLGFLLPLVVILFCYGS 189
                        170
                 ....*....|....*
gi 966963638 262 IYKAARKSAAKHKFP 276
Cdd:cd15372  190 VLHTLLRSGQRYGHA 204
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
98-391 1.04e-10

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 62.07  E-value: 1.04e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVaVAVMPFvSVTDLIGGkWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15181   17 GNGLVLTILLRRRRSRRTTENYLLHLALADLLL-LLTFPF-SVVESIAG-WVFGTFLCKLVGAIHKLNFYCSSLLLACIS 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLF---GWAQNVNDDKVCLISQdfgYTIYST---------- 244
Cdd:cd15181   94 VDRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCFLLSLPNLVfleVETSTNANRTSCSFHQ---YGIHESnwwltsrfly 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 245 -AVAFYIPMSVMLFMYYQIYKAARKSAakhkfpgfPRVEpdsvialngivklqkeveecanlsrllkherknisifkrEQ 323
Cdd:cd15181  171 hVVGFFLPLLIMGYCYATIVVTLCQSS--------RRLQ---------------------------------------KQ 203
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966963638 324 KAATTLGIIVGAFTVCWLPF----FLLSTARPFICGTSCScIPLWVERTFL---WLGYANSLINPFIYAF----FNRDL 391
Cdd:cd15181  204 KAIRVAILVTLVFCLCWLPYniviFLDTLDDLKAVVKNCK-LNDLLDAAITvteSLGFSHCCLNPILYAFigvkFRNDL 281
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
98-395 1.28e-10

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 62.36  E-value: 1.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15218   17 GNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPFVFTSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCIS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLF--GWAQNVNDDKVCLISQ-------DFGYTIYSTAVAF 248
Cdd:cd15218   97 VTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLdvGTYSFIREEDQCTFQHrsfrandSLGFMLLLALILL 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 249 YIPMSVMLFMYY----------QIYKA-----------ARKSAAKHKFPGFPR-VEPDSVIALngivklqKEVEECANLS 306
Cdd:cd15218  177 ATQLVYLKLIFFvhdrrkmkpvQFVAAvsqnwtfhgpgASGQAAANWLAGFGRgPTPPTLLGI-------RQNANTTGRR 249
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 307 RLLKHERknisiFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGtscSCIPLWVERTFLWLGYANSLINPFIYAF 386
Cdd:cd15218  250 RLLVLDE-----FKMEKRISRMFYIMTFLFLTLWGPYLVACYWRVFARG---PVVPGGFLTAAVWMSFAQAGINPFVCIF 321

                 ....*....
gi 966963638 387 FNRDLRTTY 395
Cdd:cd15218  322 SNRELRRCF 330
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
115-392 2.30e-10

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 61.04  E-value: 2.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 115 PSNYLIVSLALADLSVAVAvMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTyPVRQ 194
Cdd:cd15925   35 PIDVFVFNLALADFGFALT-LPFWAVESALDFHWPFGGAMCKMVLTATVLNVYASVFLLTAMSVTRYWVVASAAG-PGTH 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 195 NGKCMAKMI-LSVWLLSASITLP-PLFGWAQNVNDDKVCLISQDFG-----YTIYSTAVAFYIPMSVMLFMYYQIykaar 267
Cdd:cd15925  113 LSTFWAKIItLALWAAALLATVPtAIFATEGEVCGVELCLLKFPSNywlgaYHLQRVVVAFVVPLGVITTSYLLL----- 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 268 ksaakhkfpgfprvepdsvialngivklqkeveecanLSRLLKHeRKNISIFKREQKAATTLGIIVGAFTVCWLP----- 342
Cdd:cd15925  188 -------------------------------------LSFLQQH-KVNQNNRQRQSVIARSVRLVVASFFLCWFPnhvvt 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 966963638 343 -FFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15925  230 fWGVLVKFRAVPWNSTFYFIHTYVFPVTTCLAHSNSCLNPVLYCLMRREFR 280
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
98-329 2.33e-10

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 60.99  E-value: 2.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVtdLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15121   17 GNLFVVWSVLCRMKKRSVTCILVLNLALADAAVLLTAPFFLHF--LSGGGWEFGSVVCKLCHYVCGVSMYASIFLITLMS 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFgWAQNVNDD---KVCLISQD------FGYtIYSTAVAF 248
Cdd:cd15121   95 MDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSLPMPF-YRTVLKKNinmKLCIPYHPsvgheaFQY-LFETITGF 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 249 YIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEpdSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATT 328
Cdd:cd15121  173 LLPFTAIVTCYSTIGRRLRSARFRRKRRTNRLVV--LIIATFALFWLPYHVVNLIQVAGALQNQAGNASVLKAAKLARPN 250

                 .
gi 966963638 329 L 329
Cdd:cd15121  251 V 251
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
98-392 2.53e-10

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 61.29  E-value: 2.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGgKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15397   17 GNICLICVIARQKEKTNVTNILIANLSFSDILVCLVCLPFTVVYTLMD-YWIFGEVLCKMTPFIQCMSVTVSILSLVLIA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAkmILSVWLLSASITLP-------------PLFGWAQNVNDDKVCLIS-----QDFGY 239
Cdd:cd15397   96 LERHQLIINPTGWKPSVSQAYLA--VVVIWMLACFISLPflafhiltdepykNLSHFFAPLADKAVCTESwpsehHKLAY 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 240 TIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKhkfpgFPRVEPDSVialngivklqkeveecanlsRLLKHERKNIsif 319
Cdd:cd15397  174 TTWLLLFQYCLPLLFILVCYLRIYLRLRRRKDM-----LERRGEYNR--------------------RAGHSKRINV--- 225
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966963638 320 kreqkaatTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15397  226 --------MLVSLVAAFALCWLPLNVFNAIADWNHEAIPHCQHNLIFSLCHLAAMASTCVNPIIYGFLNSNFK 290
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
97-392 2.65e-10

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 60.98  E-value: 2.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIgGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15395   16 SGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMCLPFTFVYTLM-DHWVFGEAMCKLNSMVQCISITVSIFSLVLI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAkmILSVWLLSASITLPPLFGWA------QNVN-------DDKVCL-----ISQDFG 238
Cdd:cd15395   95 AIERHQLIINPRGWRPNNRHAYVG--IAVIWVLAVLTSLPFLIFQVltdepfKNVNvsldaykGKYVCLdqfpsDTIRLS 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 239 YTIYSTAVAFYIPMSVMLFMYYQIYKAARKSaakhkfpgfprvepdsvialNGIVKLQKEveecaNLSRLLKHERKNISI 318
Cdd:cd15395  173 YTTCLLVLQYFGPLCFIFICYLKIYIRLKRR--------------------NNMMDKMRD-----NKYRSSETKRINIML 227
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966963638 319 FKreqkaattlgiIVGAFTVCWLPFFLLSTARPFICGTSCSCiplwvERTFLWL-----GYANSLINPFIYAFFNRDLR 392
Cdd:cd15395  228 IS-----------IVVAFAVCWLPLNIFNAVFDWNHEAIATC-----NHNLLFLichltAMISTCVNPIFYGFLNKNFQ 290
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
98-268 3.28e-10

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 60.49  E-value: 3.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVaVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15161   17 GNTLALWLFIHDRKSGTPSNVFLMHLAVADLSY-VLILPMRLVYHLSGNHWPFGEVPCRLAGFLFYLNMYASLYFLACIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTyPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNV--NDDKVCL---ISQDFGYTIYSTAVAFYIPM 252
Cdd:cd15161   96 VDRFLAIVHPVK-SMKIRKPLYAHVVCGFLWVIVTVAMAPLLVSPQTVevNNTTVCLqlyREKASRGALVSLAVAFTIPF 174
                        170
                 ....*....|....*.
gi 966963638 253 SVMLFMYYQIYKAARK 268
Cdd:cd15161  175 VTTVTCYLLIIRSLRT 190
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
97-395 3.82e-10

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 60.52  E-value: 3.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADlSVAVAVMPfVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15087   16 TGNTAVIYVILRAPKMKTVTNVFILNLAIAD-DLFTLVLP-INIAEHLLQQWPFGELLCKLILSIDHYNIFSSIYFLTVM 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGI-----TRPLTYPVRQNGKCMAkmiLSVWLLSASITLPPLFGWAQNVNDDKV--CLIS----QDFGY---TIY 242
Cdd:cd15087   94 SVDRYLVVlatvrSRRMPYRTYRAAKIVS---LCVWLLVTIIVLPFTVFAGVYSNELGRksCVLSfpspESLWFkasRIY 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 243 STAVAFYIPMSVMLFMYYQIYKAARKsaakhkfpgfprvepdsvialngivklqkeveecanlSRLLKHERkniSIFKRE 322
Cdd:cd15087  171 TLVLGFAIPVSTICILYTMMLYKLRN-------------------------------------MRLNSNAK---ALDKAK 210
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966963638 323 QKAATTLGIIVGAFTVCWLPFFLLSTArpfICGTSCSCIPLWVERTFLW--LGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15087  211 KKVTLMVLVVLAVCLFCWTPFHLSTVV---ALTTDLPQTPLVIGISYFItsLSYANSCLNPFLYAFLDDSFRKSF 282
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
98-395 4.68e-10

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 60.58  E-value: 4.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKK---LRQPSNYLIVSLALADLSVAVAVMPfvsvTDLIGGKWI-----FGHFFCNVFIAMDVMCCTAS 169
Cdd:cd15135   17 GNSATIKVTQVLQKkgyLQKSVTDHMVSLACSDLLVLLLGMP----VELYSAIWDpfatpSGNIACKIYNFLFEACSYAT 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 170 IMTLCVISIDRYLGITRPLTYPVRQNGKcMAKMILSVWLLSASITLPPLF---------------GWAQNVNDDK----V 230
Cdd:cd15135   93 ILNVATLSFERYIAICHPFKYKALSGSR-VRLLICFVWLTSALVALPLLFamgtedpleafpsyrGTRHHCQDQKsnltI 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 231 CL-ISQD---FGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAkhkfpgfPRVEpdsVIALNGIVKLQKEVEecanlS 306
Cdd:cd15135  172 CTsLSSKwtvFQASIFSAFVLYLLVLASVAFMCRRMMRALMGSKK-------GAVA---VKGPGGSVQLLRKHE-----S 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 307 RLLKHERKNISIFkreqkaattLGIIVGAFTVCWLPF---FLLSTARPFICGT----SCSCIPLWVERTFLWLgyaNSLI 379
Cdd:cd15135  237 AEGKTARKQTILF---------LGLIVGTLAVCWMPNqirRIMAAAKPKDDWTrsyfRAYIILLPIADTFFYL---SSVL 304
                        330
                 ....*....|....*.
gi 966963638 380 NPFIYAFFNRDLRTTY 395
Cdd:cd15135  305 NPLLYNLSSQQFRSVF 320
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
98-392 4.98e-10

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 61.18  E-value: 4.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVvISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFVSVTDLigGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:PHA02638 115 GNAAI-IMILFCKKIKTITDIYIFNLAISDL-IFVIDFPFIIYNEF--DQWIFGDFMCKVISASYYIGFFSNMFLITLMS 190
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGW--------AQNVND---DKVCLISQDFGYTIYS--- 243
Cdd:PHA02638 191 IDRYFAILYPISFQKYRTFNIGIILCIISWILSLIITSPAYFIFeasniifsAQDSNEtisNYQCTLIEDNEKNNISflg 270
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 244 -------TAVAFYIPMSVMLFMYYQIykaarksaakhkfpgfprvepdsvialngIVKLQKeveecanlsrlLKHERKNI 316
Cdd:PHA02638 271 rilqfeiNILGMFIPIIIFAFCYIKI-----------------------------ILKLKQ-----------LKKSKKTK 310
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 317 SIfkreqkaaTTLGIIVGAFTVCWLPF---FLLSTARPF----------ICGtscsciplwvertFLWLGYANSL----- 378
Cdd:PHA02638 311 SI--------IIVSIIIICSLICWIPLnivILFATMYSFkgfnsiisehICG-------------FIKLGYAMMLaeais 369
                        330
                 ....*....|....*....
gi 966963638 379 -----INPFIYAFFNRDLR 392
Cdd:PHA02638 370 lthccINPLIYTLIGENFR 388
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
98-395 5.19e-10

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 60.24  E-value: 5.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15133   17 GNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLELYELWQNYPFLLGSGGCYFKTFLFETVCLASILNVTALS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLP-----PLFGWAQNVNDDKVCLISQD---FGYTIYSTAVAFY 249
Cdd:cd15133   97 VERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSMLCALPntslhGIKFLGSGVPASAQCTVRKPqaiYNMIPQHTGHLFF 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 250 I-PMSVMLFMYYQIYKAARKSAAkHKFPGFPRVEPDSVialngivklqkeveecanlSRLLKHERKNISIFKreqkaatT 328
Cdd:cd15133  177 VlPMAVISVLYLLMALRLARERG-LDATGAGSKIGTRT-------------------GQLLQHPRTRAQVTK-------M 229
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966963638 329 LGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLW-----VERTFLWLGyanSLINPFIYAFFNRDLRTTY 395
Cdd:cd15133  230 LFILVVVFAICWAPFHIDRLMWSFISDWTDNLHEVFqyvhiISGVFFYLS---SAVNPILYNLMSTRFREMF 298
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
98-216 5.98e-10

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 59.77  E-value: 5.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVaVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15162   17 ANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVI-WLPFKIAYHIHGNNWIFGEALCRLVTVAFYGNMYCSILLLTCIS 95
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLP 216
Cdd:cd15162   96 IDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLP 134
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
98-392 7.50e-10

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 59.85  E-value: 7.50e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGgKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15396   17 GNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMCIPFTAVYTLMD-HWIFGETMCKLTSFVQSVSVSVSIFSLVLIA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAkmILSVWLLSASITLPplFGWAQNVNDDKVCLISQDFGY-----------------T 240
Cdd:cd15396   96 IERYQLIVNPRGWKPSASHAYWG--IVLIWLFSLMISIP--FLIFHQLTDEPFRNLSSHSDFykdkvvcieawpseterL 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 241 IYSTAV---AFYIPMSVMLFMYYQIYKAARKSaakhkfpgfprvepdsvialNGIVKLQKEveecaNLSRLLKHERKNis 317
Cdd:cd15396  172 IFTTSLlvfQYFVPLGFIFICYLKIFVCLKKR--------------------NSKIDRMRE-----NESRLSENKRIN-- 224
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966963638 318 ifkreqkaaTTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15396  225 ---------TMLISIVVTFAACWLPLNIFNVVFDWNHEVLMSCHHNLVFTLCHLVAMVSTCINPIFYGFLNKNFQ 290
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
98-393 7.72e-10

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 59.30  E-value: 7.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAvMPFVSVTDLIGgkWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15182   17 GNGLVLWILVKYEKLKTLTNIFILNLAISDLLFTFT-LPFWASYHSSG--WIFGEILCKAVTSIFYIGFYSSILFLTLMT 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFgWAQNVNDDKVCLISQDFGYTIYSTAVA-----FYIPM 252
Cdd:cd15182   94 IDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPELI-LSTVMKSDEDGSLCEYSSIKWKLGYYYqqnlfFLIPL 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 253 SVMLFMYYQIYKA--ARKSAAKHKfpgfprvepdsvialngIVKLqkeveecanlsrllkherknisIFkreqkaattlg 330
Cdd:cd15182  173 GIIVYCYVRILQTlmRTRTMRKHR-----------------TVKL----------------------IF----------- 202
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 331 IIVGAFTVCWLPF----FLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRT 393
Cdd:cd15182  203 VIVLVFFLSWAPYniviFLRSLKDLTIPICECSKQLDYAFYICRNIAFSHCCLNPVFYVFVGVKFRN 269
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
99-392 7.82e-10

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 59.41  E-value: 7.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT-----DLIGGKWIFGHFFcnVFIAMdvmccTASIMTL 173
Cdd:cd15349   18 NLLVLLAILRRVRLRRWVYICLANIALSDLLTGTSYLVNICLSgertfRLTPALWFLREGL--LFTAL-----AASTFSL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 174 CVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWaQNVNDDKVC-----LISQDFgytIYSTAVAF 248
Cdd:cd15349   91 LVTAVERYATMVRPVAENTATKTYRVYGMIVLCWILAFLIGFLPLLGW-NCLCDFRSCssllpLYSKSY---ILFCLVIF 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 249 YIPMSVMLFMYYQIYKAARKSAAKhkfpgfprvepdsVIALNgivklqkeveecanlSRllkherknisifKREQKAATT 328
Cdd:cd15349  167 FIILLTIIGLYFAIYCLVRASGQR-------------VISAR---------------SR------------RRSLRLLKT 206
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966963638 329 LGIIVGAFTVCWLPFFLLSTARPFicGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15349  207 VLMILGAFMVCWGPLFILLLVDFF--CSSRSCKPLFGMEWVLALAVLNSAINPLIYSFRSLEVR 268
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
99-392 9.60e-10

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 59.07  E-value: 9.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGkWIFGHFFCNVFIAMDVMCCTASIMTLCVISI 178
Cdd:cd15078   18 NLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVRGR-WVFDVAGCVWDGFSNSLFGIVSIMTLTVLAY 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 179 DRYLGItrplTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVND--------DKVCLISQDFGYTIYSTAVAFYI 250
Cdd:cd15078   97 ERYIRV----VHAKVVNFSWSWRAITYIWLYSLAWTGAPLLGWNRYTLEvhglgcsfDWKSKDPNDTSFVLLFFLGCLVV 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 251 PMSVMLFMYYQIYKAarksaakhkfpgfprvepdsvialngiVKLQKEVEECANLsrllkherKNISIFKREQKAATTLG 330
Cdd:cd15078  173 PLGIMAYCYGHILYE---------------------------IRMLRSVEDLQTF--------QVIKILKYEKKVAKMCL 217
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966963638 331 IIVGAFTVCWLPFFLLSTARPFicGTSCSCIPLWVERTFLwLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15078  218 LMISTFLICWMPYAVVSLLVTS--GYSKLVTPTIAIIPSL-FAKSSTAYNPVIYIFMIRKFR 276
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
98-386 1.16e-09

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 59.01  E-value: 1.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVaVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15200   17 GNGIALFIFCFHRRPWKSNTMYLLSLVVADFFL-IINLPFRIDYYLRNEVWRFGATACQVNLFMLSMNRTASIVFLTAIA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFgwAQNVNDDKVCLisqdfGYTIYSTAVA---------- 247
Cdd:cd15200   96 LNRYLKVVHPHHQLSKASVGCAAKVAAGLWILILLLNIHLLL--LDHVQSNSTCL-----SYDHGTDPSAsdrwhrilff 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 248 --FYIPMSVMLFMYYQIykaarksaakhkfpgfprvepdsvialngivklqkeveecanlsrLLKHERKNISIFKREQKA 325
Cdd:cd15200  169 leFFLPLGIILFCIFSI---------------------------------------------ILTLKQRKLAKQAGPQRA 203
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966963638 326 ATTLGIIVGAFTVCWLPFFLLSTA-----RPFICGTSCSCIPLWveRTFLWLGYANSLINPFIYAF 386
Cdd:cd15200  204 VKVLAVIVLVYTVCFLPSILFALAslvafKVSQCRSLDLCTQLF--HGSLAFTYLNSALDPVLYCF 267
7tmA_S1PR2_Edg5 cd15347
sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...
99-392 1.62e-09

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320469 [Multi-domain]  Cd Length: 266  Bit Score: 58.29  E-value: 1.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVsvtdLIGGKWIFG----HFFCNVFIAMDVMCctASIMTLC 174
Cdd:cd15347   18 NLLVLIAVARNKKFHSAMFFFIGNLAFSDLLAGVAFIANI----LLSGSVTFRltpvQWFIREGTAFITLS--ASVFSLL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 175 VISIDRYLGITRPLTYPVRQNGKcMAKMILSVWLLSASITLPPLFGWAQNVN-DDKVCLISQDFGYTIYSTAVAFYIPMS 253
Cdd:cd15347   92 AIAIERHVAITKVKLYGSDKNCR-MVLLIGACWVISIVLGGLPILGWNCIGNlEDCSTVLPLYSKHYILFVVTIFSIILL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 254 VMLFMYYQIYKAARKSAAkhkfpgfprvepdsvialngivklqkEVEECANLSrLLKherknisifkreqkaatTLGIIV 333
Cdd:cd15347  171 SIVILYVRIYCIVRSSHA--------------------------EMAAPQTLA-LLK-----------------TVTIVL 206
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966963638 334 GAFTVCWLPFFLLstarpFICGTSC---SCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15347  207 GVFIVCWLPAFII-----LLLDTSCkvkSCPILYKADYFFSVATLNSALNPVIYTLRSKDMR 263
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
98-392 2.20e-09

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 58.16  E-value: 2.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFVSVTDLIGgkWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15180   17 GNGLVLAVLLQKRRNLSVTDTFILHLALADI-LLLVTLPFWAVQAVHG--WIFGTGLCKLAGAVFKINFYCGIFLLACIS 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTY-----PVRQNGKCMAkmilsVWLLSASITLPP-LFGWAQNVNDDKVCLISQDFGY---------TIY 242
Cdd:cd15180   94 FDRYLSIVHAVQMysrkkPMLVHLSCLI-----VWLFCLLLSIPDfIFLEATKDPRQNKTECVHNFPQsdtywwlalRLL 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 243 STAVAFYIPMSVMLFMYYQIykaarksaakhkfpgfprvepdsvialngivklqkeveecanLSRLLKHERKnisifKRE 322
Cdd:cd15180  169 YHIVGFLLPLAVMVYCYTSI------------------------------------------LLRLLRSSQG-----FQK 201
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966963638 323 QKAATTLGIIVGAFTVCWLPF---FLLST-ARPFICGTSCSC-IPLWVERTFL-WLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15180  202 QRAIRVIVAVVVVFFLCWTPYniaLLVDTlIDLSVLDRNCGTeSRLDIALSVTsSLGYFHCCLNPLLYAFVGVKFR 277
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
98-343 2.26e-09

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 58.24  E-value: 2.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15358   17 GNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPLELYEMWSNYPFLLGAGGCYFKTLLFETVCFASILNVTALS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPL--TYPVRQNGkcMAKMILSVWLLSASITLP----------PLFGwAQNVNDDKVCLISQD---FGYTIY 242
Cdd:cd15358   97 VERYIAVVHPLkaKYVVTRTH--AKRVIGAVWVVSILCSIPntslhgifqlTVPC-RGPVPDSATCMLVKPrwmYNLIIQ 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 243 STAVAFY-IPMSVMLFMYYQIYKAARKSAAkhkfpgfprvepdsVIALNgiVKLQKEVEECANLsRLLKHERknisifkR 321
Cdd:cd15358  174 ITTLLFFfLPMGTISVLYLLIGLQLKREKM--------------LLVLE--AKGSKAGDSYQHR-RIQQEKR-------R 229
                        250       260
                 ....*....|....*....|..
gi 966963638 322 EQKAATTLGIIVGAFTVCWLPF 343
Cdd:cd15358  230 RRQVTKMLFVLVVVFGICWAPF 251
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
98-216 2.77e-09

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 57.86  E-value: 2.77e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAvAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15368   17 GNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLA-CFLPFQIVYHIQRNHWIFGKPLCNVVTVLFYANMYSSILTMTCIS 95
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLP 216
Cdd:cd15368   96 IERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTALSP 134
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
99-278 3.24e-09

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 57.47  E-value: 3.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLR-QPSNYLIVSLALADLSVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15219   17 NLLVLLCFLYSAELRkQVPGIFLLNLSFCNLLLTVLNMPF-TLLGVVRNRQPFGDGFCQAVGFLETFLTSNAMLSMAALS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLF----GWAQNVNDDKVCLISQDFG-----YTIYSTAVAF 248
Cdd:cd15219   96 IDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHSLTFSLVALFlswlGYSSLYASCTLHLPREEERrrfavFTAFFHAFTF 175
                        170       180       190
                 ....*....|....*....|....*....|
gi 966963638 249 YIPMSVMLFMYYQIYKAARKSAAKHKFPGF 278
Cdd:cd15219  176 LLSLLVLCVTYLKVLKVRRRQRATKKISIF 205
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
134-218 4.44e-09

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 57.10  E-value: 4.44e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 134 VMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASI 213
Cdd:cd15120   51 ILPFMAVHVLMDNHWAFGTVLCKVLNSTLSVGMFTSVFLLTAISLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAILL 130

                 ....*
gi 966963638 214 TLPPL 218
Cdd:cd15120  131 SIPYL 135
7tmA_LPAR cd15101
lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane ...
99-395 4.61e-09

lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341325 [Multi-domain]  Cd Length: 274  Bit Score: 57.14  E-value: 4.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTD-----LIGGKWIFGHFFCNVFIamdvmccTASIMTL 173
Cdd:cd15101   18 NLLVIAAIYKNRRFHFPIYYLLANLAAADFFAGLAYFFLMFNTGpntrrLTVSTWFLRQGLLDTSL-------TASVANL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 174 CVISIDRYLGITRPLTYPVRQNGKCMAkMILSVWLLSASITLPPLFGWAQNVNDDKVC----LISQDF-GYTIYSTAVAF 248
Cdd:cd15101   91 LAIAVERHISVMRMQLHSRLSNRRVVV-LIVLVWTMAIVMGAIPSVGWNCLCAIDACSnmapLYSRSYlVFWAISNLVTF 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 249 YipmsVMLFMYYQIYKAARksaakhkfpgfprvepdsvialngivklQKEVEECANLSRLLKHERKNISIFKreqkaatT 328
Cdd:cd15101  170 L----VMVVVYARIFVYVR----------------------------RRTNRMSPHTSGSIRNRDTMMSLLK-------T 210
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 329 LGIIVGAFTVCWLP---FFLLSTARPFICGTscscipLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15101  211 VVIVLGAFVVCWTPglvVLLLDGLCCRQCNV------LAVEKFFLLLAEFNSAVNPIIYSYRDKEMSGTF 274
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
98-391 4.73e-09

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 57.11  E-value: 4.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVaVMPFVsVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd14975   17 GNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLL-TLPVW-IYFLATGTWDFGLAACKGCVYVCAVSMYASVFLITLMS 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFgwAQNVNDDKVCLISQDFGYT--------IYSTAVAFY 249
Cdd:cd14975   95 LERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLATPVIA--FRHVEETVENGMCKYRHYSdgqlvfhlLLETVVGFA 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 250 IPMSVMLFMYYQIYKaarksaakhkfpgfprvepdsvialngivklqkeveecanlsrllkheRKNISIFKREQKAATTL 329
Cdd:cd14975  173 VPFTAVVLCYSCLLR------------------------------------------------RLRRRRFRRRRRTGRLI 204
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966963638 330 GIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTF-------LWLGYANSLINPFIYAFFNRDL 391
Cdd:cd14975  205 ASVVVAFAACWLPYHVGNLLEVVSELIGGSKMAGTLGKVAeagrpiaGALAFLSSSINPLLYAFAARGL 273
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
98-392 6.68e-09

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 56.73  E-value: 6.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVaVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15928   17 GNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFL-VLPLDLYRLWRYRPWRFGDLLCRLMYFFSETCTYASILHITALS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFgwAQNVNDDKVCLISQDFGYTIYS------------TA 245
Cdd:cd15928   96 VERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALV--LVGVEHIQGQQTPRGFECTVVNvssgllsvmlwvST 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 246 VAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDsvialngivklqkeveecanlsrllkhERKNISIfkreqka 325
Cdd:cd15928  174 SFFFVPMVCLSLLYGLIGRALWDRRQRSRTAGASRRDNN---------------------------HRQTVRM------- 219
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966963638 326 attLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPL--WVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15928  220 ---LAVIVLAFVLCWLPFHVGRVIFNHSRASTKHLHYVsqYFNLVSFVLFYLSAAINPILYNLMSKRYR 285
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
109-392 1.07e-08

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 56.39  E-value: 1.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 109 VKKLRQPSNYLIVSLALADLSVAVAVMPfVSVTDLI--GGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITR 186
Cdd:cd15355   31 LQHLQSTVHYHLASLALSDLLILLLAMP-VELYNFIwvHHPWAFGDAACRGYYFLRDACTYATALNVASLSVERYLAICH 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 187 PLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQ-----NVNDDKVCLisqdfgyTIYSTAvAFYIPMSVMLFMYYQ 261
Cdd:cd15355  110 PFKAKSLMSRSRTKKFISAIWLASALLAIPMLFTMGEqnrsgTHPGGLICT-------PIVDTS-TLKVVIQVNAFLSFL 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 262 iykaarksaakhkfpgFPRVepdSVIALNGIV--KLQKEVEECA--NLSRLLKHERKNISIFKREQKAAT------TLGI 331
Cdd:cd15355  182 ----------------FPML---VISVLNTLIanQLTVMVNQAEqeNQVCTIGGQRTVLSVSMEPGRVQSlrhgvlVLRA 242
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966963638 332 IVGAFTVCWLPFFLlstARPFICgtscsCIPLWVERTFLW------------LGYANSLINPFIYAFFNRDLR 392
Cdd:cd15355  243 VVIAFVVCWLPYHV---RRLMFC-----YVSDEQWTTFLYdfyhyfymltnvLFYVSSAINPILYNLVSANFR 307
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
98-393 1.19e-08

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 55.94  E-value: 1.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVK-KLRQPSNYLiVSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15189   17 GNLFVLLVFLLHRrRLTVAEIYL-GNLAAADL-VFVSGLPFWAMNILNQFNWPFGELLCRVVNGVIKVNLYTSIYLLVMI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTyPVRQNGKCMAKMI-LSVWLLSASITLPP-LFGWAQNVNDDKV--CLISQ-----DFGYTIYSTAVA 247
Cdd:cd15189   95 SQDRYLALVKTMA-ARRLRRRRYAKLIcVLIWVVGLLLSIPTfLLRKIKAIPDLNItaCVLLYpheawHFAHIVLLNIVG 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 248 FYIPMSVMLFMYYQIYKAARKsaakhkfpgfprvepdsvialngivklQKEVEECANlsrllkherknisifKREQKAAT 327
Cdd:cd15189  174 FLLPLLVITFCNYNILQALRT---------------------------REESTRCED---------------RNDSKATA 211
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966963638 328 TLGIIVGAFTVCWLPFFlLSTARPFICGTSCSCIPLW------VERTFLWLGYANSLINPFIYAFFNRDLRT 393
Cdd:cd15189  212 LVLAVTLLFLVCWGPYH-FFTFLDFLFDVGVLDECFWehfidiGLQLAVFLAFSNSCLNPVLYVFVGRYFRR 282
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
98-393 1.70e-08

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 55.66  E-value: 1.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAvMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15131   17 GNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLC-MPLDLYRLWQYRPWNFGDLLCKLFQFVSESCTYSTILNITALS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSAsITLPPLFGWA-------QNVNDDKVCLISQdfgYTIYSTAVAFYI 250
Cdd:cd15131   96 VERYFAICFPLRAKVVVTKRRVKLVILVLWAVSF-LSAGPIFVLVgvehengTNPIDTNECKATE---YAVRSGLLTIMV 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 251 PMSVMLFMyyqiykaarksaakhkFPGFPRVEPDSVIAlngivklqkeveecanlSRLLKHERKNI--SIFKREQKAATT 328
Cdd:cd15131  172 WVSSVFFF----------------LPVFCLTVLYSLIG-----------------RKLWRRRRENIgpNASHRDKNNRQT 218
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966963638 329 ---LGIIVGAFTVCWLPFFLlstARPFICGTSCSCIPLWVERT------FLWLGYANSLINPFIYAFFNRDLRT 393
Cdd:cd15131  219 vkmLAVVVFAFVLCWLPFHV---GRYLFSKSFEAGSLEIALISqycnlvSFVLFYLSAAINPILYNIMSKKYRV 289
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
99-395 1.78e-08

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 55.69  E-value: 1.78e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLR-QPSNYLIVSLALADLSVAVA-VMPFVSVtdliggkwifgHFF-----CNVFI---AMDVMCCTA 168
Cdd:cd15340   18 NLLVLCVILHSRSLRcRPSYHFIGSLAVADLLGSVIfVYSFLDF-----------HVFhrkdsPNVFLfklGGVTASFTA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 169 SIMTLCVISIDRYLGITRPLTYPvRQNGKCMAKMILSV-WLLSASITLPPLFGWaqnvNDDKVCLISQDFGYTIYSTAVA 247
Cdd:cd15340   87 SVGSLFLTAIDRYISIHRPLAYK-RIVTRTKAVIAFCVmWTIAIVIAVLPLLGW----NCKKLNSVCSDIFPLIDETYLM 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 248 FYIPM-SVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGivklqkeveecanlsrllkhERKNISIFKREQ--- 323
Cdd:cd15340  162 FWIGVtSVLLLFIVYAYMYILWKAHHHAVRMLQRGTQKSIIVYTS--------------------EDGKVQTTRPDQtrm 221
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 324 --KAATTLGIIVGAFTVCWLPFFLLSTARPFicgtscSCIPLWVERTFLW---LGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15340  222 diRLAKTLVLILVVLIICWGPLLAIMVYDVF------GKMNKLIKTVFAFcsmLCLLNSTVNPIIYALRSKDLRHAF 292
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
99-395 1.94e-08

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 55.21  E-value: 1.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMpfvsVTDLIGGKWIFGHFFCNVFIAMDVMCCT--ASIMTLCVI 176
Cdd:cd15345   18 NLMVLIAIWKNNRFHNRMYFFIGNLALCDLLAGIAYK----VNILMSGKKTFSLSPTQWFLREGSMFVAlgASTFSLLAI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAkMILSVWLLSASITLPPLFGW--AQNVNDDKVCLISQDFGYTIY--STAVAFYIPM 252
Cdd:cd15345   94 AIERHLTMIKMRPYDANKRYRVFL-LIGTCWLISVLLGALPILGWncLDNLPDCSTILPLYSKKYVAFciSIFIAILVAI 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 253 SVMLFMYYQIYKAARKSAAKHKfpgfprvepdsvialngivklqkeveecaNLSRLLKHERknisifkreqkaatTLGII 332
Cdd:cd15345  173 VILYARIYILVKSSSRRVTNHR-----------------------------NSERSMALLR--------------TVVIV 209
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966963638 333 VGAFTVCWLPFFLLstarpFICGTSCS---CIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15345  210 VGVFIACWSPLFIL-----LLIDVACEvkqCPILYKADWFIALAVLNSAMNPIIYTLASKEMRRAF 270
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
98-274 2.16e-08

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 55.28  E-value: 2.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALAD-------LSVAVAVMPFVSVTDLIGGKWIFGHFfCNV--FIAMdvMCCTA 168
Cdd:cd15137   17 GNLFVLIWRLKYKEENKVHSFLIKNLAIADflmgvylLIIASVDLYYRGVYIKHDEEWRSSWL-CTFagFLAT--LSSEV 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 169 SIMTLCVISIDRYLGITRPLTYpvRQNGKCMAKMILS-VWLLSASITLPPLFGWAQNVN---DDKVCL---ISQDF--GY 239
Cdd:cd15137   94 SVLILTLITLDRFICIVFPFSG--RRLGLRRAIIVLAcIWLIGLLLAVLPLLPWDYFGNfygRSGVCLplhITDERpaGW 171
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 966963638 240 tIYSTAV-------AFYIPMSVMLFMYYQIyKAARKSAAKHK 274
Cdd:cd15137  172 -EYSVFVflglnflAFVFILLSYIAMFISI-RRTRKAAASRK 211
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
98-391 2.58e-08

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 55.21  E-value: 2.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAV-AVMPFVSVTdlIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15385   17 GNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFfQVLPQLCWD--ITYRFYGPDFLCRIVKHLQVLGMFASTYMLVMM 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTyPVRQNGKCMAKMILSVWLLSASITLPP--LFGWAQNVNDDKVCLISQDF-------GYTIYSTAVA 247
Cdd:cd15385   95 TADRYIAICHPLK-TLQQPTKRSYLMIGSAWALSFILSTPQyfIFSLSEIENGSGVYDCWANFivpwgikAYITWITISI 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 248 FYIPMSVML----FMYYQIYKAARksaakhkfpgfprvepdsvialngiVKLQKEVEECANLSRLLKHERKNISIFKREQ 323
Cdd:cd15385  174 FVVPVIILLtcygFICYNIWRNIK-------------------------CKTRRGLSDNALKNILLAVCVSSVKTISRAK 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 324 -KAATTLGIIVGAFTVCWLPFFLLSTarpficgtscscIPLWVERtFLW-------------LGYANSLINPFIYAFFNR 389
Cdd:cd15385  229 iRTVKMTFVIVLAYIVCWAPFFTIQM------------WSVWDQN-FPWdesentavtitalLASLNSCCNPWIYMFFSG 295

                 ..
gi 966963638 390 DL 391
Cdd:cd15385  296 HL 297
7tmA_GPR88-like cd15211
G protein-coupled receptor 88, member of the class A family of seven-transmembrane G ...
99-283 3.21e-08

G protein-coupled receptor 88, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR88, an orphan G protein-coupled receptor, is predominantly and almost exclusively expressed within medium spiny neurons (MSNs) of the brain's striatum in both human and rodents; thus it is also called Striatum-specific GPCR (STRG). The striatum is known to involve in motor coordination, reward-based decision making, and response learning. GPR88 is shown to co-localize with both dopamine D1 and D2 receptors and displays the highest sequence similarity to receptors for biogenic amines such as dopamine and serotonin. GPR88 knockout mice showed abnormal behaviors observed in schizophrenia, such as disrupted sensorimotor gating, increased stereotypic behavior and locomotor activity in response to treatment with dopaminergic compounds such as apomorphine and amphetamine, respectively, suggesting a role for GPR88 in dopaminergic signaling. Furthermore, the transcriptional profiling studies showed that GPR88 expression is altered in a number of psychiatric disorders such as depression, drug addiction, bipolar and schizophrenia, providing further evidence that GPR88 plays an important role in CNS signaling pathways related to psychiatric disorder. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320339 [Multi-domain]  Cd Length: 283  Bit Score: 54.47  E-value: 3.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGkwIFGHFFCNVFIAMDVMCCTASIMTLCVISI 178
Cdd:cd15211   17 NVLVIYLVVSFKKLQTTSNAFIVNGCVADLLVCAFWMPQEAVLGSTGT--LLVLGYRLFREGLLFLGLTVSLLSHSLIAL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 179 DRYLGITR-PLTYPVRQNGKCMAKMILSVWLLSASItLPPLFGWAQNVNDDKVCLISQDFG--------YTIYSTAVAFY 249
Cdd:cd15211   95 NRYVLITKlPAVYQALYQKRNTEWMIALSWALALGL-LLPWLTSFRYPTKSCHDSADGSFAvvsvlssrYPALLLAFTVL 173
                        170       180       190
                 ....*....|....*....|....*....|....
gi 966963638 250 IPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEP 283
Cdd:cd15211  174 GQTALVLHCYFGIFRRVQISVKRVSVLNFQIVNN 207
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
98-387 3.22e-08

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 54.78  E-value: 3.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAV-AVMP--FVSVTDLIGGKwifgHFFCNVFIAMDVMCCTASIMTLC 174
Cdd:cd15388   17 SNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFfQVLPqlVWDITDRFRGP----DVLCRLVKYLQVVGMFASSYMIV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 175 VISIDRYLGITRPLTYPVRQNGKCMAKMILSvWLLSASITLPPLFGWAQ-----NVNDDKVCLIsQDFG---YTIYSTAV 246
Cdd:cd15388   93 AMTFDRHQAICRPMVTFQKGRARWNGPVCVA-WAISLILSLPQVFIFSKvevapGVYECWACFI-EPWGlkaYVTWITLV 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 247 AFYIPMSVMLFMYYQIYKAarksaakhkfpgfprvepdsvIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAA 326
Cdd:cd15388  171 VFVLPTLIITVCQVLIFKE---------------------IHINIYLKSQIIVAVVKKKQLLSSRASSVAEVSKAMIKTV 229
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966963638 327 TTLGIIVGAFTVCWLPFFLlstarpficgtscscIPLW--------VER-TF---LWLGYANSLINPFIYAFF 387
Cdd:cd15388  230 KMTLVIVLVYVLCWAPFFL---------------VQLWsvwdpkapTEGaTFtilMLLASLNSCTNPWIYMAF 287
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
98-386 3.25e-08

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 54.67  E-value: 3.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAvMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15201   17 GNGLALWIFCFHLKSWKSSTVYLFNLAVADFLLIIC-LPFRTDYYLRGKHWKFGDIPCRIVLFMLAMNRAGSIFFLTAVA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLtYPVRQNGKCMAKMI-LSVWLLSASIT-----LPPLFGWaQNVNDDKVCLISQDFGYTI----YSTAVA 247
Cdd:cd15201   96 VDRYFRVVHPH-HRINSISVRKAAIIaCGLWLLTIAMTvylltKKHLFPR-GNATQCESFNICTGTDSSSnwheAMFLLE 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 248 FYIPMSVMLFMYYQIykaarksaakhkfpgfprvepdsvialngIVKLQKEveecanlsRLLKHERKnisifkreQKAAT 327
Cdd:cd15201  174 FFLPLAIILYCSVRI-----------------------------IWQLRGR--------QLDRHAKI--------KRAVQ 208
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966963638 328 TLGIIVGAFTVCWLPFFLLSTARPFICGTS---CSCIPlWVERTF---LWLGYANSLINPFIYAF 386
Cdd:cd15201  209 FIMVVAIVFIICFLPSNVTRIAIWILKHTSnedCQYYR-SVDLAFyitISFTYFNSMLDPVVYYF 272
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
109-274 3.32e-08

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 54.42  E-value: 3.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 109 VKKLRQPSNYLIvSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPL 188
Cdd:cd15366   29 VRQRNELGVYLL-NLSVSDL-LYIATLPLWIDYFLHRDNWIHGPESCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPL 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 189 TYPVRQNGKCMAKMILSVWLLSASITLPPLFGWA--QNVNDDKVCLISQDFGY-----TIYSTAVAFYIPMSVMLFMYYQ 261
Cdd:cd15366  107 RFAKVRRVKTAVAVSAVVWAIEIGANSAPLFHDElfRDRYNHTFCFEKYPMEDwvawmNLYRVFVGFLFPWVLMLFSYRG 186
                        170
                 ....*....|...
gi 966963638 262 IYKAARKSAAKHK 274
Cdd:cd15366  187 ILRAVRGNVSTEQ 199
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
98-275 4.04e-08

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 54.42  E-value: 4.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLsvaVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15187   17 GNSLVIWVLVACKKLRSMTDVYLLNLAASDL---LFVFSLPFQAYYLLDQWVFGNAMCKIVSGAYYIGFYSSMFFITLMS 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLIS----QDFGYTIYS----TAVAFY 249
Cdd:cd15187   94 IDRYLAIVHAVYALKVRTASHGTILSLALWLVAILASVPLLVFYQVASEDGRLQCIPfypgQGNSWKVFTnfevNILGLL 173
                        170       180
                 ....*....|....*....|....*.
gi 966963638 250 IPMSVMLFMYYQIYKAARKSAAKHKF 275
Cdd:cd15187  174 IPFSILIFCYHNILRNLRRCHNQNKT 199
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
97-272 4.45e-08

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 54.22  E-value: 4.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWI-----FGH-FFCNVFIAMDvmcCTasi 170
Cdd:cd15223   16 VANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTIslpgcFAQmFFIHFFTAME---SS--- 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 171 mTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLP------PLFGWAQNVNDDKVC----LISQDFGYT 240
Cdd:cd15223   90 -ILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPivvlasQLSYCSSNVIEHCYCdhmaLVSLACGDT 168
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 966963638 241 ----IYSTAVAFYIP---MSVMLFMYYQIYKAARKSAAK 272
Cdd:cd15223  169 tinsIYGLAVAWLIVgsdIILIFFSYALILRAVLRLASG 207
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
97-273 5.29e-08

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 54.01  E-value: 5.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVaVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd14988   16 VENVLVIWVNWHRWGSKNLVNLYILNMAIADLGV-VLTLPVWMLEVMLDYTWLWGSFLCKFTHYFYFANMYSSIFFLTCL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDF-GYTIYSTAVA-------F 248
Cdd:cd14988   95 SVDRYLTLTSSSPFWQQHQHRIRRALCAGIWVLSAIIPLPEVVHMQLLDGVEPMCLFLAPFeTYDEWALAVSlltliigF 174
                        170       180
                 ....*....|....*....|....*....
gi 966963638 249 YIPMSVM----LFMYYQIYKAARKSAAKH 273
Cdd:cd14988  175 LIPFSIIavfnVLTARYIRTAGRPESRRH 203
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
99-392 5.87e-08

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 53.69  E-value: 5.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLR-QPSNYLIVSLALADLsvavavmpFVSVTDLIggKWIFGHFF-----CNVF---IAMDVMCCTAS 169
Cdd:cd15099   18 NILVLLTILSSTALRrRPSYLFIGSLALADM--------LASVIFTI--SFLDFHVFhqrdsRNLFlfkLGGVTMAFTAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 170 IMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWaQNVNDDKVCliSQDFGYtIYSTAVAFY 249
Cdd:cd15099   88 VGSLLLTALDRYLCIYQPSNYKLLVTRTRAKVAILLMWCVTIIISFLPLMGW-RCKTWDSPC--SRLFPY-IDRHYLASW 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 250 IPM-SVMLFM----YYQIYKAARKSAAKHKFPGFPRVEpdsviaLNGIVKLQKEVeecanlsrllkherknisifkreqK 324
Cdd:cd15099  164 TGLqLVLLFLiiyaYPYILWKAHRHEANMGGPKLGRQQ------VKGQARMRMDI------------------------R 213
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966963638 325 AATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCsciplwVERTFLW---LGYANSLINPFIYAFFNRDLR 392
Cdd:cd15099  214 LAKTLSLILLVLAICWLPVLAFMLVDVRVTLTNK------QKRMFAFcsmLCLVNSCVNPIIYALRSRELR 278
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
99-269 6.35e-08

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 53.52  E-value: 6.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAV--AVMPFVSvtdlIGGKWIFG------HFFCNVFIAMdvmcctASI 170
Cdd:cd15072   18 NGLTILSFCKTRELRTPSNLLVLSLAVADMGISLnaLVAASSS----LLRRWPYGsegcqaHGFQGFFTAL------ASI 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 171 MTLCVISIDRYLGITRPLTYpvrqNGKCMAKMILSVWLLSASITLPPLFGWAqnvNDD-----KVCLI---SQDFGYTIY 242
Cdd:cd15072   88 CSSAAIAWDRYHHYCTRSKL----QWSTAISLVLFVWLFSAFWAAMPLLGWG---EYDyeplgTCCTLdysKGDRNYVSY 160
                        170       180       190
                 ....*....|....*....|....*....|
gi 966963638 243 STAVAFY---IPMSVMLFMYYQIYKAARKS 269
Cdd:cd15072  161 LFTMAFFnfiLPLFILLTSYSSIEQKLKKE 190
7tmA_LPAR3_Edg7 cd15343
lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial ...
99-395 6.46e-08

lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320465 [Multi-domain]  Cd Length: 274  Bit Score: 53.73  E-value: 6.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVT-----DLIGGKWIFGHFFCNVFIamdvmccTASIMTL 173
Cdd:cd15343   18 NSLVIAAVVKNKRFHYPFYYLLANLAAADFFAGIAYVFLMFNTgpvskTLTVNRWFLRQGLLDTSL-------SASLTNL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 174 CVISIDRYLGITRpltYPVRQN--GKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDF--GYTIY---STAV 246
Cdd:cd15343   91 LVIAVERHISIMR---MKVHSNltKRRVTLLIALVWAIAIFMGAVPTLGWNCICNISACSSLAPIYsrSYLVFwsvSNLV 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 247 AFYIpmsvMLFMYYQIYKAARKSAakhkfpgfprvepdsvialngivklqkeveecanlSRLLKHERKNISIFKREQKAA 326
Cdd:cd15343  168 VFLI----MVVVYLRIYVYVQRKT-----------------------------------NVLSPHTSGSINRRRTPIKLM 208
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 327 TTLGIIVGAFTVCWLPFFLLStarpFICGTSCS-CIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15343  209 KTVMTVLGAFVICWTPGLVVL----LLDGLNCTrCGVQHVKRWFLLLALLNSVMNPIIYSYKDEEMWGTM 274
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
97-293 6.61e-08

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 53.55  E-value: 6.61e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVV-ISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFVSVTDLIGGKWIFGH---------FFCNVFiamdvmcc 166
Cdd:cd15376   16 LGNGLALwLFVTRERRPWHTGVVFSFNLAVSDL-LYALSLPLLAAYYYPPKNWRFGEaacklerflFTCNLY-------- 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 167 tASIMTLCVISIDRYLGITRPLTYPVRQNGKcMAKMI-LSVWLLSASITLPPLFGWAQNVNDDK--VCLISQD------- 236
Cdd:cd15376   87 -GSIFFITCISLNRYLGIVHPFFTRSHVRPK-HAKLVsLAVWLLVAALSAPVLSFSHLEVERHNktECLGTAVdsrlpty 164
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 237 FGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSaakhkfPGFPRVEPDSVIALNGIV 293
Cdd:cd15376  165 LPYSLFLAVVGCGLPFLLTLASYLAIVWAVLRS------PGITTLEKRKVAALVAVV 215
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
99-268 9.73e-08

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 53.22  E-value: 9.73e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADL--SVAVAVMPFVSVTDLIGGK-----WIFGHFFCNVFIAmdvmcctasim 171
Cdd:cd15905   16 NLFIILGIACNRKLHNTANYFFLSLLLADLltGVALPFIPGMSNESRRGYHsclfvYVAPNFLFLSFLA----------- 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 172 TLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWaQNVNDDKVCLISQDFGYT-IYSTAVAFYI 250
Cdd:cd15905   85 NLLMVHYERYLCIVYPLQYHNFWVHRWVPLALLLTWALPLLFACLPALGW-NNWTPGSNCSYKQVFPAAyIYLEVYGLVL 163
                        170
                 ....*....|....*....
gi 966963638 251 P-MSVMLFMYYQIYKAARK 268
Cdd:cd15905  164 PsILAIAFMSVRVLAVARR 182
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
99-259 1.14e-07

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 52.86  E-value: 1.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAvMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISI 178
Cdd:cd15968   18 NSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALS-LPLLIYNYAMRDRWLFGDFMCRLVRFLFYFNLYGSILFLTCISV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 179 DRYLGITRPLTyPVRQNGKCMAKMI-LSVWLLSASITLPPLFgWAQN--VNDDKVC-------LISQDFGYTIYSTAVAF 248
Cdd:cd15968   97 HRYLGICHPMR-PWHKETRRAAWLTcVLVWILVFAQTLPILI-FARTgiIRNRTVCydlappaLFPHYVPYGMALTVSGF 174
                        170
                 ....*....|.
gi 966963638 249 YIPMSVMLFMY 259
Cdd:cd15968  175 LLPFSIILWCY 185
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
97-395 1.32e-07

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 52.81  E-value: 1.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15000   15 FGNFVLLYILASNRSLRTPTNLLIGNMALADL-LTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSLLLASVLALCAV 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITrpLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVN-----DDKVC----LISQDFGYTIYSTAVa 247
Cdd:cd15000   94 SYDRLTAIV--LPSEARLTKRGAKIVIVITWIVGLLLALPLAIYRSYRERqwknfLETYCaentQVLPIYWHVIITVLV- 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 248 fYIPMSVMLFMYYQIYkaarksaakhkfpgfprvepdsvialngiVKLQKEVEecanlsRLLKHERKNISIFKReqKAAT 327
Cdd:cd15000  171 -WLPLGIMLICYSAIF-----------------------------WKLDKYER------RVLRREHPSVVRYKK--KAAK 212
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966963638 328 TLGIIVGAFTVCWLPFFLLSTARPFICG-------TSCSCIPLWVERTFLWlgYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15000  213 TLFIVLITFVVCRIPFTALIFYRYKLVPndntqnsVSGSFHILWFASKYLM--FLNAAVNPLIYGFTNENFRKAF 285
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
98-395 1.40e-07

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 52.49  E-value: 1.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAvMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15199   17 GNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLLIC-LPFKAYFYLNGNRWSLGGGTCKALLFMLSLSRGVSIAFLTAVA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRP---LTYPVRQNGKCMAKMilsVWLLSASITLPPLFGWAQNVNDDKVCLISQDFG--YTIYSTAVAFY--- 249
Cdd:cd15199   96 LDRYFRVVHPrgkKNSLSLQAAPYISFL---VWLLLVGLTIPTLLASQPKNFTECNSFSPKDDEdfSDTWQEAVFFLqfl 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 250 IPMSVMLFMYYQIykaarksaakhkfpgfprvepdsvialngIVKLQKEVEECANLSRLlkherknisifkreQKAATTL 329
Cdd:cd15199  173 LPFGLIVFCTVRI-----------------------------IRRLKKRLRDVGKQPKL--------------QRAMALV 209
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966963638 330 GIIVGAFTVCWLPFFLlstARP----FICGTSCS--CIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15199  210 TSVVVVFGFCFLPCFL---ARVlmliFQNKESCNalNIAVHTYDVTMCLTYLNSVLDPIVYCFSSPTFRSSY 278
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
99-395 1.87e-07

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 52.09  E-value: 1.87e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADL--SVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMD---VMCCTASIMTL 173
Cdd:cd15350   18 NLLVLVAVIKNKNLHSPMYFFICSLAVSDMlgSLYKTLENILIILADMGYLNRRGPFETKLDDIMDslfCLSLLGSIFSI 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 174 CVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSA--SITLPPLFgwaqnvnddkvclisqDFGYTIYSTAVAFYIP 251
Cdd:cd15350   98 LAIAADRYITIFHALRYHNIMTMRRTLVILAIIWTFCGgsGILMILFF----------------HFVATVICFTVLFFLM 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 252 MSVMLFMYYQIYKAARKSAAKhkfpgfprvepdsvialngIVKLQKEVEEcanlsrllkHERKNIsifkreqKAATTLGI 331
Cdd:cd15350  162 LVLILCLYVHMFLLARSHARK-------------------IASLPNHHAQ---------HQRSNM-------RGAITLTI 206
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 332 IVGAFTVCWLPFF---LLSTARPFICGTSCSCIPLWVERTFLwlgYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15350  207 LLGVFVCCWAPFVlhlLLMMFCPMNPYCACYRSLFQVNGTLI---MSHAVIDPAIYAFRSPELRNTF 270
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
98-392 1.91e-07

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 52.22  E-value: 1.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMpFVSVTDLIggkwIFGHFF-----------CNV--FIAmdVM 164
Cdd:cd15136   17 GNIIVLLVLLTSRTKLTVPRFLMCNLAFADFCMGIYLG-LLAIVDAK----TLGEYYnyaidwqtgagCKTagFLA--VF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 165 CCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGwaqnVND---DKVCL-----ISQD 236
Cdd:cd15136   90 SSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPLVG----VSSyskTSICLpfeteTPVS 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 237 FGYTIYS---TAVAFYIpmsvMLFMYYQIYKAARKsaakhkfPGFPRVEPDSVIAlngivklqkeveecanlsrllkher 313
Cdd:cd15136  166 KAYVIFLllfNGLAFLI----ICGCYIKIYLSVRG-------SGRAANSNDTRIA------------------------- 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 314 knisifKReqkaattLGIIVGAFTVCWLP--FFLLSTArpficgTSCSCIPLWVERTFLWLGYA-NSLINPFIYAFFNRD 390
Cdd:cd15136  210 ------KR-------MALLVFTDFLCWAPiaFFGLTAA------FGLPLISVSNAKILLVFFYPlNSCANPFLYAIFTKQ 270

                 ..
gi 966963638 391 LR 392
Cdd:cd15136  271 FR 272
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
99-393 2.18e-07

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 52.16  E-value: 2.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLiGGKWIFGHFFCnVFIAMDV-MCCTASIMTLCVIS 177
Cdd:cd15085   18 NVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNY-EGYFYLGDAFC-IFQGFAVnYFGIVSLWSLTLLA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTyPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVND--DKVCLIS------QDFGYTIYSTAVAFY 249
Cdd:cd15085   96 YERYNVVCKPMG-GLKLSTKRGYQGLLFIWLFCLFWAVAPLFGWSSYGPEgvQTSCSIGweerswSNYSYLILYFLMCFV 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 250 IPMSVMLFMYYQIYKAARksaakhkfpgfprvepdsvialngivKLQKEVEECANLSRLLKHERKNISIFkreqkaattl 329
Cdd:cd15085  175 IPVAIIGFSYGNVLRSLH--------------------------KLNKKIEQQGGKNCPEEEERAVIMVL---------- 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 330 gIIVGAFTVCWLP---FFLLSTARPFIcgtscsCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRT 393
Cdd:cd15085  219 -AMVIAFLICWLPytvFALIVVVNPEL------SISPLAATMPTYFAKTSPVYNPIIYIFLNKQFRE 278
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
108-392 2.48e-07

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 51.72  E-value: 2.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 108 FVKKLRQPSNYLIVSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRP 187
Cdd:cd15370   27 FRTKKKHPAVIYMANLALADL-LFVIWFPLKIAYHINGNNWIYGEALCKVLIGFFYGNMYCSILFMTCLSVQRYWVIVNP 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 188 LTYPvRQNGKCMAKMILSVWLLSASITLpPLFGWAQNVN----DDKVC-------LISQD-FGYTIYSTAVAFYIPMSVM 255
Cdd:cd15370  106 MSHS-RKKANIAIGISLAIWLLILLVTI-PLYLVKQTVFipalDITTChdvlpeqLLVGDmFNYFLSLAIGVFLFPAFLT 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 256 LFMYYQIYKAarksaakhkfpgfprvepdsvialngivklqkeveecanlsrlLKHERKNISIFKREQKAATTLGIIVGA 335
Cdd:cd15370  184 AVAYVLMIRA-------------------------------------------LKSSINDESIEKKRKRAIKLIVTVLVM 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966963638 336 FTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15370  221 YLICFTPSNLLLVVHYFLLKNQGQSSVYAFYITALCLSTLNSCIDPFVYYFVSHDFR 277
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
97-262 2.51e-07

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 51.71  E-value: 2.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLV-VISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFVSVTdlIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCV 175
Cdd:cd15188   16 AGNLLLfVVLLLYVPKKKKMTEVYLLNLAVSDL-LFLVTLPFWAMY--VAWHWVFGSFLCKFVSTLYTINFYSGIFFVSC 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 176 ISIDRYLGITRPLTYpvrQNGKCMAKMIL---SVWLLSASITLPPLFGWAQNVNDDKVCLISQDFG---------YTIYS 243
Cdd:cd15188   93 MSLDKYLEIVHAQSP---HRLRTRRKSLLvlvAVWVLSIALSVPDMVFVQTHHTNNGVWVCHADYGghhtiwklvFQFQQ 169
                        170
                 ....*....|....*....
gi 966963638 244 TAVAFYIPMSVMLFMYYQI 262
Cdd:cd15188  170 NLLGFLFPLLAMVFFYSRI 188
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
97-248 5.26e-07

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 51.01  E-value: 5.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGgKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15127   16 MGNVAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTK-KWLLGDFSCKIVPYIEVASLGVTTFTLCAL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITR-PLTYPVRQNGKCMAKMILSVWLLSASITLPPLF---------GWAQNVNDDKVCLISQDFGYTIYSTAV 246
Cdd:cd15127   95 CIDRFRAATNvQMYYEMIENCTSTTAKLAVIWVGALLLALPEVVlrqlskedgGSGAPPAERCVVKISTELPDTIYVLAL 174

                 ..
gi 966963638 247 AF 248
Cdd:cd15127  175 TY 176
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
109-271 6.16e-07

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 50.55  E-value: 6.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 109 VKKLRQPSNYLIvSLALADLSVAVAVMPFVSVTdLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPL 188
Cdd:cd15365   29 IRKKNELGVYLF-NLSLSDLLYIVILPLWIDYL-WNGDNWTLSGFVCIFSAFLLYTNFYTSTALLTCIALDRYLAVVHPL 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 189 TYPVRQNGKCMAKMILSVWLL---SASITLPPLFGWAQNVND----DKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQ 261
Cdd:cd15365  107 KFMHLRTIRTALSVSVAIWLLeicFNAVILTWEDSFHESSSHtlcyDKFPLEDWQARLNLFRICLGYLLPLLIILFCYWK 186
                        170
                 ....*....|
gi 966963638 262 IYKAARKSAA 271
Cdd:cd15365  187 IYQAVRSNQA 196
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
97-274 6.93e-07

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 50.53  E-value: 6.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVaVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd14987   16 LANSVVVWVNLQAKRTGYETHLYILNLAIADLCV-VATLPVWVVSLVQHNQWPMGEFTCKITHLIFSINLFGSIFFLTCM 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLF---GWAQNVNDDKVCLISQD--------FGYTIYSTA 245
Cdd:cd14987   95 SVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAFVASLPDTYflkTVTSPSNNETYCRSFYPeesfkewlIGMELVSIV 174
                        170       180
                 ....*....|....*....|....*....
gi 966963638 246 VAFYIPMSVMLFMYYQIYKAARKSAAKHK 274
Cdd:cd14987  175 LGFVIPFPIIAVFYFLLARAISASSDQER 203
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
98-268 7.31e-07

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 50.46  E-value: 7.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNcLVVISVcFVKKLR--QPSNYLIVSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCV 175
Cdd:cd15375   17 GN-IIAIFV-YLFKMRpwKSSTIIMLNLALTDL-LYVTSLPFLIYYYINGESWIFGEFMCKFIRFIFHFNLYGSILFLTC 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 176 ISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWA-QNVNDDKVCLisqDFG----------YTIYST 244
Cdd:cd15375   94 FSIFRYVVIVHPLRAFQVQKRRWAIVACAVVWVISLAEVSPMTFLITtKEKNNRTICL---DFTssdnlntiwwYNWILT 170
                        170       180
                 ....*....|....*....|....
gi 966963638 245 AVAFYIPMSVMLFMYYQIYKAARK 268
Cdd:cd15375  171 VLGFLLPLVIVTLCYTRIIYTLAK 194
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
97-387 1.41e-06

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 49.81  E-value: 1.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAV-AVMPFVsVTDlIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCV 175
Cdd:cd15387   16 TGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVfQVLPQL-IWD-ITFRFYGPDFLCRLVKYLQVVGMFASTYMLLL 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 176 ISIDRYLGITRPLTyPVRQNGKCMAkmILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDF-------GYTIYSTAVAF 248
Cdd:cd15387   94 MSIDRCLAICQPLR-SLHRRSDRVY--VLFSWLLSLVFSIPQVHIFSLREVGNGVYDCWADFiqpwgpkAYITWITLSVY 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 249 YIPMSVMLFMY----YQIYKAAR-KSAAKHKFPGFPRVEPDSVIALNGIVKLqkeveecanlsrllkherknisIFKREQ 323
Cdd:cd15387  171 IIPVLILSVCYglisFKIWQNVKlKTRRETKTPLSSAASGGAALARVSSVKL----------------------ISKAKI 228
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966963638 324 KAATTLGIIVGAFTVCWLPFFLLST-----------ARPFICGtscsciplwvertfLWLGYANSLINPFIYAFF 387
Cdd:cd15387  229 RTVKMTFVIVLAYIVCWTPFFFVQMwsvwdpnapkeASPFIIA--------------MLLASLNSCCNPWIYMFF 289
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
97-395 1.62e-06

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 49.56  E-value: 1.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSN---YLIVSLALADLSVAVAVMPfVSVTDLI--GGKWIFGHFFCNVFIAMDVMCCTASIM 171
Cdd:cd15130   16 VGNSVTLFTLARKKSLQSLQStvrYHLGSLALSDLLILLLAMP-VELYNFIwvHHPWAFGDAGCRGYYFLRDACTYATAL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 172 TLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWA-QNVNDDKVCLISQDFGYTIYSTAVAFYI 250
Cdd:cd15130   95 NVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGlQNESDDGTHPGGLVCTPIVDTATLKVVI 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 251 PMSVmlFMYYqiykaarksaakhkfpgfprVEPDSVIA-LNGIVklqkeveecanLSRLLKHERKNISIFKreqkaattl 329
Cdd:cd15130  175 QVNT--FMSF--------------------LFPMLVTSiLNTVI-----------ANKLVQALRRGVLVLR--------- 212
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966963638 330 gIIVGAFTVCWLPFFLLSTARPFICGTSCScIPLWVERTFLW-----LGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15130  213 -AVVIAFVVCWLPYHVRRLMFCYISDEQWT-TFLFDFYHYFYmltnaLFYVSSAINPILYNLVSANFRQVF 281
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
97-267 1.71e-06

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 49.27  E-value: 1.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLV-VISVCFVKKLRQPSNYLIvSLALADLSVAVAvMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCV 175
Cdd:cd15159   16 LGNTLAlHVICQKRKKINSTTLYLI-NLAVSDILFTLA-LPGRIAYYALGFDWPFGDWLCRLTALLFYINTYAGVNFMTC 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 176 ISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLF-GWAQNVNDDKVCLISQDFGYT-------IYSTAVA 247
Cdd:cd15159   94 LSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVLVFLQTLPLLFmPMTKEMGGRITCMEYPNFEKIkrlplilLGACVIG 173
                        170       180
                 ....*....|....*....|....
gi 966963638 248 FYIPMSVMLFMYYQI----YKAAR 267
Cdd:cd15159  174 FGVPVGIILFCYSQItlklCRTAK 197
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
116-218 1.73e-06

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 49.44  E-value: 1.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 116 SNYLIVSLALADLSVAVAVMPFVSVTDLIGGkWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPL-TYPVRQ 194
Cdd:cd15097   36 TNLFILNLSVADLCFILFCVPFQATIYSLEG-WVFGSFLCKAVHFFIYLTMYASSFTLAAVSVDRYLAIRYPLrSRELRT 114
                         90       100
                 ....*....|....*....|....
gi 966963638 195 NGKCMAKMILsVWLLSASITLPPL 218
Cdd:cd15097  115 PRNAVAAIAL-IWGLSLLFAGPYL 137
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
113-394 1.78e-06

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 49.45  E-value: 1.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 113 RQPSNYLIVSLALAD-LSVAVAVMPFVS--VTDLIGGKWIFGHFFCNVfiamdVMCCTASIMTLCVISIDRYLGITRPLT 189
Cdd:cd15341   33 RKPSYLFIGSLALADfLASVVFACSFVDfhVFHGVDSSAIFLLKLGGV-----TMSFTASLGSLLLMAFDRYVCIYYPSE 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 190 YPVRQNGKCMAKMILSVWLLSASITLPPLFGWaQNVNDDKVC-----LISQDFgytIYSTAVAFYIPMSVMLFMYYQIYK 264
Cdd:cd15341  108 YKALVTRKRALVALAVMWVLTALIAYLPLMGW-NCCPLNSPCselfpLIPNDY---LLSWLLLVAILLSGIIYTYGHVLW 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 265 AARKSAAKhkfpgfprVEPDSVIALNGIVKLQKEVeecanlsrllkherknisifkreqKAATTLGIIVGAFTVCWLPFF 344
Cdd:cd15341  184 KAHKHVVY--------MEKHQDQQGPGNARMRLDV------------------------RLAKTLGLVLAVLLICWSPVL 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 966963638 345 LLSTARPFICGTSCsciplwVERTFLW---LGYANSLINPFIYAFFNRDLRTT 394
Cdd:cd15341  232 ALMMHSLFTSLSDH------IKKAFAFcstLCLVNSMVNPIIYALRSRELRSS 278
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
98-395 1.92e-06

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 49.04  E-value: 1.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15921   17 GNSISVYVFLSQYRSQTPVSVLMVNLAISDL-LLVCTLPLRLTYYVLNSHWPFGDIACRIILYVLYVNMYSSIYFLTALS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKV-CL----ISQDFGYTIYSTA--VAFYI 250
Cdd:cd15921   96 VFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPLLFAKSKQHDEGSTrCLelahDAVDKLLLINYVTlpVGFVV 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 251 PMSVMLFMYYQIYKAarksaakhkfpgfprvepdsvialngivklqkeveecanlsrLLKHERKNISIFKREQKAATTLG 330
Cdd:cd15921  176 PFMTVIFCYIFIIKN------------------------------------------LLKPSPALGRTRPSRRKACALII 213
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966963638 331 IIVGAFTVCWLPFFLLSTARPFI---CGTSCSCIpLWVERTF---LWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15921  214 ISLGIFLVCFLPYHIVRTIHLITerqIKESCGYI-LRVRKAAvitLCLAASNSCFDPLLYFFVGENFRSRL 283
7tmA_SREB1_GPR27 cd15216
super conserved receptor expressed in brain 1 (or GPR27), member of the class A family of ...
97-395 2.24e-06

super conserved receptor expressed in brain 1 (or GPR27), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320344 [Multi-domain]  Cd Length: 332  Bit Score: 49.25  E-value: 2.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIF---GHFFCNVFIAMDVMCCTASIMTL 173
Cdd:cd15216   16 AGNVLFALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVMLAARRAAAAAGtppGALGCKLLAFLAALFCFHAAFLL 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 174 CVISIDRYLGITRPLTYPVRQNG-KCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQD-------FGYTIYSTA 245
Cdd:cd15216   96 LGVGVTRYLAIAHHRFYAERLAGwPCAAMLVCAAWALALAAAFPPVLDGGGADDEDAPCALEQRpdgapgaLGFLLLLAA 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 246 V--AFYIPMSVMLFMYYQIYK-------------------AARKSAAKHKFPGFPRvePDSVIALNGIvklqKEVEECAN 304
Cdd:cd15216  176 VvgATHLVYLRLLFFIHDRRKmrparlvpavshdwtfhgpGATGQAAANWTAGFGR--GPTPPALVGI----RPAGPGRG 249
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 305 LSRLLKHERknisiFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFIcgtSCSCIPLWVERTFLWLGYANSLINPFIY 384
Cdd:cd15216  250 ARRLLVLEE-----FKTEKRLCKMFYAITLLFLLLWGPYVVASYLRVLV---RPGAVPQAYLTASVWLTFAQAGINPVVC 321
                        330
                 ....*....|.
gi 966963638 385 AFFNRDLRTTY 395
Cdd:cd15216  322 FLFNRELRDCF 332
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
110-222 2.31e-06

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 49.09  E-value: 2.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 110 KKLRQPSNYLIVSLALADLSVAVAVMPfVSVTDLIGGKWIFGH-----FFCNVFIAMDVMCCTASIMTLCVISIDRY--- 181
Cdd:cd15975   29 KCMRNGPNALIASLALGDLIYIVIDIP-INVYKLLAQKWPFDDssfgvFLCKLVPFLQKASVGITVLNLCALSVDRYrav 107
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 966963638 182 ------LGITRPLTYPVRqngkcmakmILSVWLLSASITLPPLFGWA 222
Cdd:cd15975  108 aswsrvQGIGIPLITAIE---------IFSIWVLSFILAIPEAIGFV 145
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
98-221 2.52e-06

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 49.06  E-value: 2.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPfVSVTDLIGGKWIFGH-----FFCNVFIAMDVMCCTASIMT 172
Cdd:cd15128   17 GNSTLLRIIYQNKCMRNGPNALIASLALGDLLYIVIDLP-INVYKLLAMDWPFGDqpfgqFLCKLVPFIQKASVGITVLN 95
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 966963638 173 LCVISIDRYLGITRplTYPVRQNGKCM--AKMILSVWLLSASITLPPLFGW 221
Cdd:cd15128   96 LCALSVDRYRAVAS--WSRIQGIGIPMwtAVEIVMIWMLSAVLAVPEAIGF 144
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
99-218 2.66e-06

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 48.61  E-value: 2.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISI 178
Cdd:cd15369   18 NILALVVFLRKMRVKKPAVIYMLNLACADL-LFVLLLPFKIAYHFSGNDWLFGEAMCRVVTAAFYCNMYCSILLMTCISV 96
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 966963638 179 DRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPL 218
Cdd:cd15369   97 DRFLAVVYPMQSLSWRTLRRASFTCAAIWLLSIAGVVPLL 136
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
123-262 3.18e-06

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 48.64  E-value: 3.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 123 LALADLSVAVAvMPFVSVTDLIGGKWIFghffCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKM 202
Cdd:cd15920   42 LALADLLLVLC-LPFRVAYQNTAGPLSF----CKIVGAFFYLNMYASILFLSLISLDRYLKIIKPLQQFKIHTVPWSSAA 116
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966963638 203 ILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT---IYSTAVA-FYIPMSVMLFMYYQI 262
Cdd:cd15920  117 SGGVWLLLLACMIPFLFESRNEGPCDNKCFHFRSKGLTaggINLTAVViFYILSLLFLYFYAKI 180
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
115-272 3.20e-06

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 48.64  E-value: 3.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 115 PSNYLIVSLALADLSVAVaVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQ 194
Cdd:cd15371   33 CTAIFYANLAISDLLFCI-TLPFKIVYHLNGNNWVFGETMCRIITITFYGNMYCSILLLTCISINRYLAIVHPFIYRSLP 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 195 NGKCMAKMILSVWLLSASITLP------------PLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQI 262
Cdd:cd15371  112 KKTYAVLICALVWTIVFLYMLPffilkqtyylkeLNITTCHDVLPECEQNSNFQFYYFISMAVFGFLIPLVITIFCYISI 191
                        170
                 ....*....|
gi 966963638 263 YKAARKSAAK 272
Cdd:cd15371  192 IRTLNAYEHK 201
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
99-259 3.33e-06

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 48.55  E-value: 3.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVmPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISI 178
Cdd:cd15922   18 NSFSLWIFWFRIKQWSSGTILQFNLALSDAIITPAA-PLLIAYFSLGSHWPFGQFLCQLKVFLLSTHMYGSIYFLMLISI 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 179 DRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKV-CL-ISQD------FGYTIYSTAVAFYI 250
Cdd:cd15922   97 HRYVTVVHYNWKSLWKKKSFMKKLCLGVWLLLFVQGLPFFFVLKTSVIDGKTkCLsIHQSelsllyFVWNFVLLILGFLL 176

                 ....*....
gi 966963638 251 PMSVMLFMY 259
Cdd:cd15922  177 PFGVSLTCY 185
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
97-211 4.31e-06

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 48.02  E-value: 4.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWI-FGHFFCNVFiaMDVMCCTASIMTLCV 175
Cdd:cd15232   16 TGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTIsFGGCMAQLY--FFTWSLGSELLLLTA 93
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 966963638 176 ISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSA 211
Cdd:cd15232   94 MAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGM 129
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
98-219 4.96e-06

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 47.84  E-value: 4.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVcfVKKLRQPS--NYLIVSLALADLSVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCV 175
Cdd:cd15398   17 GNLLILTAL--TKKWKQKTiiNFLIGNLAFSDILVVLFCSPF-TLTCVLLDQWIFGEVMCHIVPFLQCVSVMVSTLMLMS 93
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 966963638 176 ISIDRYLGITRPLTYPVRQNGKCMakMILSVWLLSASITLP-PLF 219
Cdd:cd15398   94 IAIVRYHMIKHPLSNHLTANHGYF--LLGTVWTLGFTICSPlPVF 136
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
98-392 5.29e-06

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 47.83  E-value: 5.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFVSVTdlIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15184   17 GNMLVVLILINCKKLKSMTDIYLLNLAISDL-LFLLTLPFWAHY--AANEWVFGNAMCKLLTGLYHIGFFSGIFFIILLT 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGI--------TRPLTYPVRQNGkcmakmilSVWLLSASITLPPLFgWAQNVNDDKVCLISQDFGYTIYSTAVAFY 249
Cdd:cd15184   94 IDRYLAIvhavfalkARTVTFGVVTSV--------VTWVVAVFASLPGII-FTKSQKEGSHYTCSPHFPPSQYQFWKNFQ 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 250 ----------IPMSVMLFMYYQIYKAarksaakhkfpgfprvepdsvialngivklqkeveecanlsrLLKHERKnisif 319
Cdd:cd15184  165 tlkmnilglvLPLLVMIICYSGILKT------------------------------------------LLRCRNE----- 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 320 KREQKAATTLGIIVGAFTVCWLPF---FLLSTARPFICGTSCSC-----IPLWVERTflwLGYANSLINPFIYAFFNRDL 391
Cdd:cd15184  198 KKRHKAVRLIFTIMIVYFLFWAPYnivLLLNTFQEFFGLNNCSSsnrldQAMQVTET---LGMTHCCINPVIYAFVGEKF 274

                 .
gi 966963638 392 R 392
Cdd:cd15184  275 R 275
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
98-392 6.58e-06

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 47.56  E-value: 6.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPF--VSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCV 175
Cdd:cd15006   16 GNFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLVCVPFdiVLSASPHCCWWIYTLLFCKVIKFLHKVFCSVTVLSFAA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 176 ISIDRYLGITRPLTYPVRQNGKcmAKMILSVWlLSASITLPPLFGwAQNVND---DKVCLISQDFG-----YTIYSTAVA 247
Cdd:cd15006   96 IALDRYYSVLYPLERKISDAKS--RDLVIYIW-AHAVVASVPVFA-VTNVTDiyaMSTCTESWGYSlghlvYVIIYNITT 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 248 FYIPMSVMLFMYYQIYKAARKSAAKhkfpgfprvepDSVIAlngivklqkeveecanlsrLLKHERKNISI---FKREQK 324
Cdd:cd15006  172 VILPVAVVFLFMILIRRALSASQKK-----------KVIIA-------------------ALRTPQNTISIpyvSQREAE 221
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966963638 325 AATTLGIIVGAFTVCWLPFFLLSTARPFIcgtSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15006  222 LHAMLLSMVLVFILCSVPYATLVIYRTIL---NISDISVFLLLTAIWLPKVSLLANPLLFLTVNKSVR 286
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
98-210 6.89e-06

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 47.60  E-value: 6.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWI-FGH-----FFcnvFIAMDVMcctaSIM 171
Cdd:cd15235   18 GNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTIsYAGclaqmYF---FIAFGNT----DSF 90
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 966963638 172 TLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLS 210
Cdd:cd15235   91 LLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLS 129
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
107-262 7.07e-06

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 47.33  E-value: 7.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 107 CFVKKLRQPSNYLIvSLALADLsVAVAVMPFVSVtdLIGGKWIFGHFFCN-----VFIAMdvmccTASIMTLCVISIDRY 181
Cdd:cd15165   27 FKIKKWTESTIYMI-NLALNDL-LLLLSLPFKMH--SSKKQWPLGRTLCSfleslYFVNM-----YGSILIIVCISVDRY 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 182 LGITRPLTYPVRQNGKCMAKMILSVWLLSASITLpPLFGWAQNVNDDKVCLisQDFGYTIYSTAV-------AFYIPMSV 254
Cdd:cd15165   98 IAIRHPFLAKRLRSPRKAAIVCLTIWVFVWAGSI-PIYSFHDKPTNNTRCF--HGFSNKTWSKKVivvveefGFLIPMAV 174

                 ....*...
gi 966963638 255 MLFMYYQI 262
Cdd:cd15165  175 MVFCSVQI 182
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
99-259 7.29e-06

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 47.56  E-value: 7.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISI 178
Cdd:cd15379   18 NAVVIGQIWATRQALSRTTIYMLNLATADL-LYVCSLPLLIYNYTQKDYWPFGDFTCRLVRFQFYTNLHGSILFLTCISV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 179 DRYLGITRPLTYPVRQNGKCMAKMIL-SVWLLSASITLPP-LFGWAQNVNDDKVC-------LISQDFGYTIYSTAVAFY 249
Cdd:cd15379   97 QRYLGICHPLASWHKKKGKKLTWLVCgAVWLVVIAQCLPTfVFASTGTQRNRTVCydlsppaRSTAYFPYGITLTRTGFL 176
                        170
                 ....*....|
gi 966963638 250 IPMSVMLFMY 259
Cdd:cd15379  177 LPFAARLACY 186
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
98-393 8.10e-06

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 47.49  E-value: 8.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15380   17 GNLFVLFVFLLPRRRLTIAEIYLANLAASDL-VFVLGLPFWAENIRNQFNWPFGNFLCRVISGVIKANLFISIFLVVAIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTYPvRQNGKCMAKMI-LSVWLLSASITLPP-LFGWAQNVNDDKVCLISQDFGYTIYSTA-------VAF 248
Cdd:cd15380   96 QDRYRTLVHTMTSR-RQRSRRQAQVIcLLIWVFGGLLSIPTfLFRSVKHVPDLNISACILLFPHEAWHFArrvelniVGF 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 249 YIPMSVMLFMYYQIykaarksaakhkfpgfprvepdsvialngivklqkeveecanLSRLLKHERKNISIFK--REQKAA 326
Cdd:cd15380  175 LLPLAAIVFFNFHI------------------------------------------IASLRERTEESRKRCGglKDTKAT 212
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966963638 327 TTLGIIVGAFTVCWLPFFLLSTARpFICGTSCSCIPLWVERTFL------WLGYANSLINPFIYAFFNRDLRT 393
Cdd:cd15380  213 RLILTLVLMFLVCWTPYHFFAFLD-FLFQVEVIQGCFWEEFIDLglqlanFFAFANSCLNPVIYVFAGKLFRT 284
7tmA_ETBR-LP2 cd15126
endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G ...
98-221 8.25e-06

endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelin B receptor-like protein 2, also called GPR37L1, is almost exclusively expressed in the nervous system. It has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37L1 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320254  Cd Length: 298  Bit Score: 47.17  E-value: 8.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVsVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15126   17 GNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFFCLPVV-VFNEITKKRLLGDVSCRVVPYMEVTSLGVTTFSLCALG 95
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 966963638 178 IDRYLGITRPL--TYPVRQNGKCMAKMILsVWLLSASITLPPLFGW 221
Cdd:cd15126   96 IDRFHAATSPQpkARPVERCQSILAKLAV-IWVGSMTLAVPELLLW 140
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
108-212 1.33e-05

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 46.48  E-value: 1.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 108 FVKKLRQ---PSNYLIVSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGI 184
Cdd:cd15170   25 FIRKVRRkptPIDILLLNLTVSDL-IFLLFLPFKMAEAASGMIWPLPYFLCPLSSFIFFSTIYISTLFLTAISVERYLGV 103
                         90       100       110
                 ....*....|....*....|....*....|
gi 966963638 185 TRPLTYPVRQngKCMAKMILSV--WLLSAS 212
Cdd:cd15170  104 AFPIKYKLRR--RPLYAVIASVffWVLAFS 131
7tmA_LPAR1_Edg2 cd15344
lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial ...
98-395 1.62e-05

lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341348 [Multi-domain]  Cd Length: 273  Bit Score: 46.17  E-value: 1.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTD-----LIGGKWIFGHFFCNVFIamdvmccTASIMT 172
Cdd:cd15344   17 ANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGpntrrLTVSTWLLRQGLIDTSL-------TASVAN 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 173 LCVISIDRYLGITRpLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFG--YTIYsTAVAFYI 250
Cdd:cd15344   90 LLAIAIERHITVFR-MQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSdsYLVF-WAIFNLV 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 251 PMSVMLFMYYQIYKAARksaakhkfpgfprvepdsvialngivklQKEVEECANLSRLLKHERKNISIFKreqkaatTLG 330
Cdd:cd15344  168 TFVVMVVLYAHIFGYVR----------------------------QRTMRMSRHSSGPRRNRDTMMSLLK-------TVV 212
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966963638 331 IIVGAFTVCWLPFFLLSTARpfICGTSCSCipLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY 395
Cdd:cd15344  213 IVLGAFIICWTPGLVLLLLD--VCCPQCDV--LAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATF 273
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
125-392 1.64e-05

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 46.29  E-value: 1.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 125 LADLSVAVaVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMIL 204
Cdd:cd15924   43 VADLLMIL-TFPFKILSDAGLGPWQLRTFVCRVTSVLFYFTMYTSIVFLGLISIDRYLKIVRPFKTSFPKSVSFAKILSV 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 205 SVWLLSASITLPPLFGWAQNVNDDKV--CL-ISQDFGY-----TIYSTAVAFYIPMSVMLFMYYQIykaarksaAKHKFP 276
Cdd:cd15924  122 VVWALMFLLSLPNMILTNQQPREKNVkkCSfLKSELGLkwheiVNYICQVIFWIVFLLMIVCYTAI--------TKKVYR 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 277 GFPRVEPDSVIAlngivklqkeveecanlsrllkHERKNISIFkreqkaattlgIIVGAFTVCWLPF------FLLS-TA 349
Cdd:cd15924  194 SYRRVFRSSSSR----------------------RKKSNVKIF-----------IIVAVFFVCFVPYhfaripYTLSqTR 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 966963638 350 RPFICgtSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15924  241 DVFDC--TAENILFYVKEATLFLSALNVCLDPIIYFFLCKSFR 281
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
98-219 1.90e-05

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 46.27  E-value: 1.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFvkKLRQPSNYL-IVSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFC--NVFIAMDVMccTASIMTLC 174
Cdd:cd15119   17 GNAIVIWVTGF--KWKKTVNTLwFLNLAIADF-VFVLFLPLHITYVALDFHWPFGVWLCkiNSFVAVLNM--FASVLFLT 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 966963638 175 VISIDRYLGITRP-LTYPVRQNGKCMAkMILSVWLLSASITLPPLF 219
Cdd:cd15119   92 VISLDRYISLAHPvWSHRYRTLKSALI-LCGIVWLSAAAISGPALY 136
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
98-265 2.04e-05

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 46.06  E-value: 2.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVV-ISVCFVKKLRQPSNYLIvSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15377   17 GNSVAIwMFVFHMKPWSGISVYMF-NLALADF-LYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLF--GWAQNVNDDKVCL--ISQDF--GYTIYS---TAVA 247
Cdd:cd15377   95 SVHRYTGVVHPLKSLGRLKKKNAICISVLVWLIVVVAISPILFysGTGVRKNKTITCYdtTSDEYlrSYFIYSmctTVAM 174
                        170
                 ....*....|....*...
gi 966963638 248 FYIPMSVMLFMYYQIYKA 265
Cdd:cd15377  175 FCVPFILILGCYGLIVRA 192
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
110-345 2.46e-05

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 46.00  E-value: 2.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 110 KKLRQPSNYLIVSLALADLSVAVAVMPfVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLT 189
Cdd:cd15976   29 KCMRNGPNILIASLALGDLLHIIIDIP-INVYKLLAEDWPFGVEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSR 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 190 YPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDK-----VCLISqdfgytiystavafyiPMSVMLFMyyQIYK 264
Cdd:cd15976  108 IKGIGVPKWTAVEIVLIWVVSIILAVPEAIGFDMITMDYKgellrICLLH----------------PIQKTAFM--QFYK 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 265 AARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERknisifkreqKAATTLGIIVGAFTVCWLPFF 344
Cdd:cd15976  170 TAKDWWLFSFYFCLPLACTAVFYTLMTCEMLRKKNGMQIALNDHLKQRR----------EVAKTVFCLVLVFALCWLPLH 239

                 .
gi 966963638 345 L 345
Cdd:cd15976  240 L 240
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
99-268 2.76e-05

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 45.61  E-value: 2.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISI 178
Cdd:cd15156   18 NCVAIYIFMCTLKVRNETTTYMINLAISDL-LFVFTLPF-RIFYFVQRNWPFGDLLCKISVTLFYTNMYGSILFLTCISV 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 179 DRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLF---GWAQNVNDDKVCL--ISQDFGYT------IYSTAVA 247
Cdd:cd15156   96 DRFLAIVYPFRSKTLRTKRNAKIVCAAVWLTVLAGSLPASFfqsTNNQLNNNSETCFenFSSKTWKTylskivIFIEIVG 175
                        170       180
                 ....*....|....*....|.
gi 966963638 248 FYIPMSVMLFMYYQIYKAARK 268
Cdd:cd15156  176 FFIPLILNVTCSTMVLKTLRR 196
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
98-392 2.90e-05

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 45.52  E-value: 2.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFvkKLRQPSNYL-IVSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFC--NVFIAMDVMCCtaSIMTLC 174
Cdd:cd15116   17 GNGLVIFITGF--KMKKTVNTVwFLNLAVADF-LFTFFLPFSIAYTAMDFHWPFGRFMCklNSFLLFLNMFT--SVFLLT 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 175 VISIDRYLGITRPLTypvRQNGKC--MAKMI-LSVWLLSASITLPPlfgwaqnvnddkvcLISQDFGYTIYSTAVAFYIP 251
Cdd:cd15116   92 VISIDRCISVVFPVW---SQNHRSvrLASLVsLAVWVVAFFLSSPS--------------FIFRDTAPSQNNNKIICFNN 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 252 MSVMLFMYYQIYKAARKSaaKHKFPGFPRVEPDSVIALNGIVklqkeveeCANLSRLLKHERKNISIFKREQKAATTlgI 331
Cdd:cd15116  155 FSLSGDNSSPEVNQLRNM--RHQVMTITRFLLGFLIPFTIII--------CCYAAIVLKLKRNRLAKSSKPFKIIAA--V 222
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966963638 332 IVgAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLwLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15116  223 IV-TFFLCWAPYHILNLLEMEATRSPASVFKIGLPITSS-LAFINSCLNPILYVFMGQDFK 281
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
120-274 3.38e-05

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 45.51  E-value: 3.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 120 IVSLALADLSVAVAvMPFVSVTDLIGGKWIFGHFFCNV---FIAMDVMCctaSIMTLCVISIDRYLGITRPL---TYPVR 193
Cdd:cd15147   41 MVNLTIADLLFLIT-LPFWIVYYHNEGNWILPKFLCNVagcLFFINTYC---SVAFLGVISYNRYQAVTRPIktaQSTTR 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 194 QNGKCMAkmiLSVWLLSASITLPPLFGWAQNVNDDKVCLISQDF-GYTIYST----------AVAFYIPMSVMLF----- 257
Cdd:cd15147  117 KRGIIIS---VAIWVIIVASASYFLFMDSTNTVKIDSGNFTRCFeGYEKDNSkpvliihfiiIGLFFLVFLLILVcnlvi 193
                        170       180
                 ....*....|....*....|
gi 966963638 258 ---MYYQIYKAARKSAAKHK 274
Cdd:cd15147  194 artLLSQPVQGQRNAGVKRR 213
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
110-216 4.06e-05

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 45.28  E-value: 4.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 110 KKLRQPSNYLIVSLALADLSVAVAVMPfVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGIT---- 185
Cdd:cd15977   29 KCMRNGPNVLIASLALGDLLYILIAIP-INVIKLIAEDWPFGVHVCKLYPFIQKASVGITVLSLCALSIDRYRAVAswsr 107
                         90       100       110
                 ....*....|....*....|....*....|..
gi 966963638 186 -RPLTYPVRQngkcmAKMILSVWLLSASITLP 216
Cdd:cd15977  108 iRGIGIPVWK-----AVEVTLIWAVAIIVAVP 134
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
97-210 5.45e-05

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 44.68  E-value: 5.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15148   16 VGNLLALWVFLFIHRKRNSVRIFLINVAIADL-LLIICLPFRILYHVNNNQWTLGPLLCKVVGNLFYMNMYISIILLGFI 94
                         90       100       110
                 ....*....|....*....|....*....|....
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLS 210
Cdd:cd15148   95 SLDRYLKINRSSRRQKFLTRKWSIVACGVLWAVA 128
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
114-386 5.99e-05

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 44.70  E-value: 5.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 114 QPS------NYLIVSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRP 187
Cdd:cd15157   27 QPSkkktsvNIFMLNLAVSDL-MFVSTLPFRADYYLMGSHWVFGDIACRIMSYSLYVNMYCSIYFLTVLSIVRFLAIVHP 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 188 LTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCL------ISQDFGYTIYSTAVAFYIPMSVMLFMYYQ 261
Cdd:cd15157  106 FKLWKVTSIKYARILCAVIWIFVMAASSPLLSKGTSKYNSQTKCLdlhpskIDKLLILNYIVLVVGFILPFCTLSICYIL 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 262 IYKAarksaakhkfpgfprvepdsvialngivklqkeveecanlsrLLKHERKNISIFKREQKAATTLGIIVGAFTVCWL 341
Cdd:cd15157  186 IIKA------------------------------------------LLKPRVPQSKLRVSHKKALLTIIITLILFLLCFL 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 966963638 342 PFFLLSTArpFICGTSCSCIPLWVERTF---LWLGYANSLINPFIYAF 386
Cdd:cd15157  224 PYHILRTV--HLMQWSEGQCNLRLHKAVvitLCLAAANSCLDPLLYYF 269
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
99-270 6.01e-05

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 44.53  E-value: 6.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISI 178
Cdd:cd15155   18 NCASLFVFCFRMKMRNETAIFMTNLAVSDL-LFVFTLPF-KIFYNFNRHWPFGDSLCKISGTAFLTNIYGSMLFLTCISV 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 179 DRYLGITRPLTYPVRQNGKCMAKMILSVWL--LSASITLpPLFGWAQNVNDDKVCLisQDFGYTIYST----------AV 246
Cdd:cd15155   96 DRFLAIVYPFRSRTIRTRRNSAIVCAGVWIlvLSGGISA-SLFSTTNVSNTSTTCF--EGFSKSIWKTylskitifieVV 172
                        170       180
                 ....*....|....*....|....
gi 966963638 247 AFYIPMSVMLFMYYQIYKAARKSA 270
Cdd:cd15155  173 GFIIPLLLNLTCSSLVLRTLRKPA 196
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
98-190 6.83e-05

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 44.41  E-value: 6.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNY--LIVSLALADLSVAVAVMPfVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCV 175
Cdd:cd15142   17 GNLIAIVVLCKSRKEQKETTFytLVCGLAVTDLLGTCLASP-VTIATYLKGRWPGGQPLCEYFSFILLFFSLSGLSIICA 95
                         90
                 ....*....|....*
gi 966963638 176 ISIDRYLGITRPLTY 190
Cdd:cd15142   96 MSIERYLAINHAYFY 110
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
98-207 7.02e-05

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 44.37  E-value: 7.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQ-PSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWI----------FGHFFCNvfiamdvmcc 166
Cdd:cd15935   17 GNLLIVVTVHADPHLLQsPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTIsfggcmaqlfFLHFLGG---------- 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 966963638 167 tASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVW 207
Cdd:cd15935   87 -SEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACW 126
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
97-219 7.02e-05

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 44.47  E-value: 7.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPS---NYLIVSLALADL-----SVAVAVMPFVSVTdligGKWIFGHFFCNVFIAMDVMCCTA 168
Cdd:cd15356   16 AGNALTIHLVLKKRSLRGLQgtvHYHLVSLALSDLlilliSVPIELYNFVWFH----YPWVFGDLVCRGYYFVRDICSYA 91
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 966963638 169 SIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLF 219
Cdd:cd15356   92 TVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFALPMAF 142
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
98-190 9.35e-05

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 43.73  E-value: 9.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWI-FGH-----FFCNVFIAmdvmcctASIM 171
Cdd:cd15226   17 GNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTIsFGGcmaqiFFLHFFGG-------SEMV 89
                         90
                 ....*....|....*....
gi 966963638 172 TLCVISIDRYLGITRPLTY 190
Cdd:cd15226   90 LLIAMAFDRYVAICKPLHY 108
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
96-215 9.39e-05

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 43.96  E-value: 9.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  96 IAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWI--FG-----HFFCnvfIAMDVMCCta 168
Cdd:cd15945   28 LVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKSIpfYGcalqmFFFA---AFADAECL-- 102
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 966963638 169 simTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITL 215
Cdd:cd15945  103 ---LLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSL 146
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
97-208 1.10e-04

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 43.58  E-value: 1.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWI-FGHFFCNVFIAMDVMCCTASIMTlcV 175
Cdd:cd15942   16 SGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIIsFGGCVTQLFFFHFLGCAECFLYT--V 93
                         90       100       110
                 ....*....|....*....|....*....|...
gi 966963638 176 ISIDRYLGITRPLTYPVRQNGKCMAKMILSVWL 208
Cdd:cd15942   94 MAYDRFLAICKPLHYSTIMNHRACLCLSLGTWL 126
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
98-219 1.17e-04

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 43.64  E-value: 1.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVsvtdlIGGKWiFGH------------FFCNVFIAMDvmc 165
Cdd:cd15222   17 GNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTV-----LGIFW-FNAreisfdaclaqmFFIHTFSFME--- 87
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 966963638 166 ctASImtLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLF 219
Cdd:cd15222   88 --SSV--LLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPF 137
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
111-394 1.18e-04

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 43.65  E-value: 1.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 111 KLRQPSNYLIV--SLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPL 188
Cdd:cd15150   27 QIPSKSNFIIFlkNTVISDL-LMILTFPFKILSDAKLGSWPLRGFVCQVTSVIFYFTMYISILFLGLITIDRYQKTTRPF 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 189 TYPVRQNGKCMAKMILSVWLLSASITLPP--LFGWAQNVNDDKVC-LISQDFGYTI-----YSTAVAFYIPMSVMLFMYY 260
Cdd:cd15150  106 KTSNPKNLLGAKILSTVIWASMFALSLPNmiLTNRQPTPKNVKKCsLLKSEFGLVWheivnYICQVIFWVNFLIVIVCYT 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 261 QIYKAARKSAAKHKfpgfprvepdsvialngivklqkeveecanLSRLLKHERKNISIFkreqkaattlgIIVGAFTVCW 340
Cdd:cd15150  186 LITKELYKSYKRTR------------------------------GVGKVSRKKVNVKVF-----------IIIAVFFICF 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966963638 341 LPF------FLLSTARP-FICgtSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTT 394
Cdd:cd15150  225 VPFhfaripYTLSQTRDvFDC--TAKNTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNS 283
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
97-207 1.18e-04

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 43.42  E-value: 1.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWI-FGHffC----NVFIAMDVMCCTasim 171
Cdd:cd15237   16 LGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTIsFVG--CaaqmFFFLALGVTECV---- 89
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 966963638 172 TLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVW 207
Cdd:cd15237   90 LLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSW 125
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
97-218 1.23e-04

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 43.63  E-value: 1.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWI---------FGHFF--CNVFIAMDVMc 165
Cdd:cd15912   16 LGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTIsfagcfaqsFFYFFlgTTEFFLLAVM- 94
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 966963638 166 ctasimtlcviSIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPL 218
Cdd:cd15912   95 -----------SFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPT 136
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
97-264 1.25e-04

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 43.67  E-value: 1.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFVSvTDLIGGkWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15186   16 VGNLLVVLALTNSGKSKSITDIYLLNLALSDL-LFVATLPFWT-HYLINE-WGLHNAMCKLTTAFFFIGFFGGIFFITVI 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWlLSASITLPPLFGWAQNVNDDkvCL-----ISQDFGYTIYSTAV---AF 248
Cdd:cd15186   93 SIDRYLAIVLAANSMNNRTVQHGVTISLGVW-AAAILVAVPQFMFTKMKENE--CLgdypeVLQEIWPVLRNVELnflGF 169
                        170
                 ....*....|....*.
gi 966963638 249 YIPMSVMLFMYYQIYK 264
Cdd:cd15186  170 LLPLLIMSYCYFRIIQ 185
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
122-389 1.34e-04

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 43.62  E-value: 1.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 122 SLALADLSVAVAvMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAK 201
Cdd:cd15969   40 NIVIADLLMTLT-FPFKIIQDSGLGPWNFNFFLCRYTSVLFYASMYTSIVFLGLISLDRYLKVVKPFGDSRMYSITFTKV 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 202 MILSVWLLSASITLPPLF---GWAQNVNDDKVCLISQDFGY-----TIYSTAVAFYIPMSVMLFMYYQIYKAARKSAakh 273
Cdd:cd15969  119 LSACVWLIMAFLSLPNIIltnGQPTEDNIHDCSKLKSPLGVkwhtaVSYINICIFVAVLVILIVCYISISRYIYKSS--- 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 274 kfpgfprvepdsvialngivklqkeveecanlsrllkheRKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPF- 352
Cdd:cd15969  196 ---------------------------------------KQFISSSSRTRKHNQSIRVVVAVFFVCFLPYHLCRIPFTFs 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 966963638 353 ----ICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNR 389
Cdd:cd15969  237 qldkILDCTIKTILYYCKEATLFLSACNVCLDPIIYFFMCR 277
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
97-215 1.65e-04

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 42.99  E-value: 1.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIF------GHFFCNVFIAMDvmcctasI 170
Cdd:cd15918   16 LGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISyagcltQMYFFLLFGDLD-------N 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 966963638 171 MTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITL 215
Cdd:cd15918   89 FLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSL 133
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
97-220 1.72e-04

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 42.98  E-value: 1.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWI-----FGHFFCNVFIAMdvMCCtasiM 171
Cdd:cd15431   16 LGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTIsysrcLAQMYISLFLGI--TEC----L 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 966963638 172 TLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFG 220
Cdd:cd15431   90 LLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVLT 138
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
98-208 1.86e-04

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 42.97  E-value: 1.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWI-FGHFFCNVFIAMDVMCctASIMTLCVI 176
Cdd:cd15939   17 GNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTIsFNGCMTQLFAEHFFGG--AEIFLLTVM 94
                         90       100       110
                 ....*....|....*....|....*....|..
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWL 208
Cdd:cd15939   95 AYDRYVAICKPLHYTTIMNRRVCGLLVGVAWV 126
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
98-184 2.00e-04

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 42.89  E-value: 2.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTdlIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15185   17 GNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFLFTLPFWIHYV--RWNNWVFGHGMCKLLSGFYYLGLYSEIFFIILLT 94

                 ....*..
gi 966963638 178 IDRYLGI 184
Cdd:cd15185   95 IDRYLAI 101
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
97-208 2.20e-04

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 42.81  E-value: 2.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVsVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVI 176
Cdd:cd15940   16 SGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKM-LSDLLSEEKTISFNGCVTQLFFLHLFACTEIFLLTIM 94
                         90       100       110
                 ....*....|....*....|....*....|..
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWL 208
Cdd:cd15940   95 AYDRYVAICNPLHYPTVMNHKVCLWLVAALWL 126
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
98-268 2.29e-04

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 42.83  E-value: 2.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVaVAVMPFVSVtdLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15923   17 LNILALWVFCWRLKKWTETNIYMTNLAVADLLL-LISLPFKMH--SYRRESAGLQKLCNFVLSLYYINMYVSIFTITAIS 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRPLTypVRQNGKCMAKMIL--SVWLLSASITLPplfGWAQNVNDDK-VCLISQDFGYTIYST----AVAFYI 250
Cdd:cd15923   94 VDRYVAIRYPLR--ARELRSPRKAAVVcaVIWVLVVTISIP---YFLLDSSNEKtMCFQRTKQTESLKVFllleIFGFLL 168
                        170
                 ....*....|....*...
gi 966963638 251 PMSVMLFMYYQIYKAARK 268
Cdd:cd15923  169 PLIIMTFCSARVIHTLQK 186
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
104-265 2.32e-04

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 42.82  E-value: 2.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 104 ISVCFVKKLRQPSNYLiVSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLG 183
Cdd:cd16001   24 LSWCRTKRWTCSTIYL-VNLAVADL-LYVCSLPLLIVNYAMRDRWPFGDFLCKLVRFLFYTNLYGSILFLTCISVHRFLG 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 184 ITRPLTYPVRQNGKCMAKMILSVWLLSASITLPP-LFGWAQNVNDDKVC--LISQD-----FGYTIYSTAVAFYIPMSVM 255
Cdd:cd16001  102 VCYPIRSLAYRTRRLAVIGSAATWILVVLQLLPTlVYARTGSINNRTVCydLTSPDnfgnyFPYGMVLTVTGFLIPFLII 181
                        170
                 ....*....|
gi 966963638 256 LFMYYQIYKA 265
Cdd:cd16001  182 LLCYCLMIKS 191
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
153-269 2.37e-04

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 42.84  E-value: 2.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 153 FFCNVFIamdvmcctaSIMTLCVISIDRYLGITRPLTYPVRQNGKcMAKMILSVWLLSASITLPPLFGWAQNVNDDK-VC 231
Cdd:cd15364   80 FFCNIYI---------SILLLCCISIDRFVAVVYALESRGRRRQR-IAAFISFLIFIVVGLVHSPVFIMREGQTEGShTC 149
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 966963638 232 -----LISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKS 269
Cdd:cd15364  150 fetlqMDTQVAGFYYARFCIGFAIPLAILIFTNYRIFRSIQTS 192
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
120-216 2.47e-04

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 42.87  E-value: 2.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 120 IVSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCM 199
Cdd:cd15118   38 ILNLALSDL-LATLSLPFFTYYLASGHTWELGTTFCRIHSSIFFLNMFVSGFLLAAISLDRCLLVVKPVWAQNHRNVAAA 116
                         90
                 ....*....|....*..
gi 966963638 200 AKMILSVWLLSASITLP 216
Cdd:cd15118  117 KKICGVIWAMALINTIP 133
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
120-274 5.12e-04

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 41.67  E-value: 5.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 120 IVSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKcm 199
Cdd:cd15367   39 LCNLTVADL-LYIFSLPFWLQYVLQHDNWTYSELLCKICGILLYENIYISIGFLCCISVDRYLAVVHPFRFHAFRTMK-- 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 200 AKMILS--VWL--LSASITLPPLFGWAQNVNDDKVCLIS---QDFGYTI--YSTAVAFYIPMSVMLFMYYQIYKAARKSA 270
Cdd:cd15367  116 AATLVStvIWLkeLMTCVFFFLHGEISKDKENHSVCFEHypiKAWEHNInyYRFYAGFLFPIFLLSFSYCRILRAVRKSH 195

                 ....
gi 966963638 271 AKHK 274
Cdd:cd15367  196 GTQK 199
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
107-219 5.12e-04

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 41.73  E-value: 5.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 107 CFVKKLRQPSNYLIvSLALADLsVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITR 186
Cdd:cd15166   27 CTTKKRTTVTVYMM-NVALVDL-IFILSLPF-RMVYYAKDEWPFGDYFCRILGALTVFYPSIALWLLAFISADRYMAIVQ 103
                         90       100       110
                 ....*....|....*....|....*....|...
gi 966963638 187 PLTYPVRQNGKCMAKMILSVWLLSASITLPPLF 219
Cdd:cd15166  104 PKHAKELKNTPKAVLACVGVWIMTLASTFPLLF 136
7tmA_FFAR1 cd15169
free fatty acid receptor 1, member of the class A family of seven-transmembrane G ...
115-274 5.32e-04

free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the mammalian free fatty acid receptor 1 (FFAR1), also called GPR40. FFAR1 is a cell-surface receptor for medium- and long-chain free fatty acids (FFAs). The receptor is most potently activated by eicosatrienoic acid (C20:3), but can also be activated at micromolar concentrations of various fatty acids. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and indirectly increases insulin secretion by enhancing the release of incretin. Free fatty acid receptors (FFARs) belong to the class A G-protein coupled receptors and are comprised of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320297  Cd Length: 284  Bit Score: 41.53  E-value: 5.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 115 PSNYLIVSLALADLSVAVAvMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTY---- 190
Cdd:cd15169   35 PSLVYALNLGCSDLLLTVS-LPLKAVEALASGAWPLPASLCPVFAVAHFAPLYAGGGFLAALSAGRYLGAAFPLGYqafr 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 191 -PVRQNGKCMAKMILSVWLLSASITLPPLFGWAQN----------VNDDKVCLISQD--------FGYTIystaVAFYIP 251
Cdd:cd15169  114 rPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHsntslgintpVNGSPVCLEAWDpasagparFSLSL----LLFFLP 189
                        170       180
                 ....*....|....*....|...
gi 966963638 252 MSVMLFMYYQIYKAARKSAAKHK 274
Cdd:cd15169  190 LAITAFCYVGCLRALARSGLTHR 212
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
98-216 7.37e-04

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 41.28  E-value: 7.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAvMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15167   17 GSCFALWAFIQKRSSRKCINIYLINLLTADFLLTLA-LPVKIAVDLGIAPWKLKIFHCQVTACLIYINMYLSIIFLGFVS 95
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 966963638 178 IDRYLGITRPLT-YPVRQNGkcMAKMILSV-WLLSASITLP 216
Cdd:cd15167   96 IDRYLQLTHSSKlYRIQEPG--FAKMISAVvWTLVLFIMVP 134
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
108-259 7.63e-04

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 41.26  E-value: 7.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 108 FVKKLRQ---PSNYLIVSLALADLsVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGI 184
Cdd:cd14983   25 FVNRARLrltPNVIYMINLCLSDL-VFILSLPI-KIVEALSSAWTLPAVLCPLYNLAHFSTLYASTCFLTAISAGRYLGV 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 185 TRPLTYPVRQNGK-----CMAKMILSVWLLSASITLPPLFGWAQ---NVNDDKVCLisQDFGYTIYSTA---------VA 247
Cdd:cd14983  103 AFPIKYQLYKKPLysclvCVAIWALVIFHVTLVFILETSGGTLDintPVGNSSTCY--ENFTPEQLALLapvrlelslVL 180
                        170
                 ....*....|..
gi 966963638 248 FYIPMSVMLFMY 259
Cdd:cd14983  181 FFLPLAITAFCY 192
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
97-218 8.66e-04

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 40.86  E-value: 8.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPfvsvtDLIGGKWIFGH-----------FFCNVFIAMDVmc 165
Cdd:cd15950   16 LGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVP-----KMLSIFWLGSAeisfeacftqmFFVHSFTAVES-- 88
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 966963638 166 ctasiMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVwLLSASITLPPL 218
Cdd:cd15950   89 -----GVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAI-VLRALLFMTPL 135
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
98-219 8.72e-04

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 41.01  E-value: 8.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFvSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15183   17 GNVLVVLVLIQHKRLRNMTSIYLFNLAISDL-VFLFTLPF-WIDYKLKDDWIFGDAMCKFLSGFYYLGLYSEIFFIILLT 94
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 966963638 178 IDRYLGITRPLtYPVRQNGKCMAkMILSV--WLLSASITLPPLF 219
Cdd:cd15183   95 IDRYLAIVHAV-FALRARTVTFG-IITSIitWALAILASMPCLY 136
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
98-262 8.95e-04

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 41.04  E-value: 8.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVvISVCFVKKLRQPSNYLIVSLALADLSVaVAVMPFVSVTDLigGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:PHA02834  45 GNVLV-IAVLIVKRFMFVVDVYLFNIAMSDLML-VFSFPFIIHNDL--NEWIFGEFMCKLVLGVYFVGFFSNMFFVTLIS 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 178 IDRYLGITRpltyPVRQNGKCMAKMIL---SVWLLSASITLPPL-FGWAQNVNDDKVCLISQ-----------DFGYTIY 242
Cdd:PHA02834 121 IDRYILVVN----ATKIKNKSISLSVLlsvAAWVCSVILSMPAMvLYYVDNTDNLKQCIFNDyhenfswsaffNFEINIF 196
                        170       180
                 ....*....|....*....|
gi 966963638 243 STAvafyIPMSVMLFMYYQI 262
Cdd:PHA02834 197 GIV----IPLIILIYCYSKI 212
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
108-259 1.32e-03

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 40.56  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 108 FVKKLR--QPSNYLIVSLALADlSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGIT 185
Cdd:cd15374   25 FIKRMRpwNPTTVYMFHLALSD-TLYVLSLPTLIYYYADHNHWPFGVVACKIVRFLFYANLYCSILFLTCISVHRYVGIC 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 186 RPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFgWAQNVNDDKVCLI-----SQDFG-YTIYSTAVA---FYIPMSVML 256
Cdd:cd15374  104 HPIRALRWVKPRHAYLICASVWLVVTVCLVPNLI-FVTTSRKDNITLChdttrPEEFDhYVHYSSAVMvllFGIPCLVIV 182

                 ...
gi 966963638 257 FMY 259
Cdd:cd15374  183 VCY 185
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
98-208 1.41e-03

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 40.13  E-value: 1.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSvavavmpFVSVT-------DLIGGKWI-FGHFFCNVFIamdVMCCTAS 169
Cdd:cd15227   17 GNLLIITVVTLDHHLHTPMYFFLKNLSFLDLC-------YISVTvpksianSLTNTRSIsFLGCVAQVFL---FIFFAAS 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 966963638 170 IMT-LCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWL 208
Cdd:cd15227   87 ELAlLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWL 126
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
99-392 1.48e-03

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 40.12  E-value: 1.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  99 NCLVVISVCFVKKLRQPSNYLIVSLALADLsVAVAVMPFVSVTDLIGGKWIFGHFFCNV--FIAMDVMCCtaSIMTLCVI 176
Cdd:cd15373   18 NILALYVFLFRTKPWNASTTYMFNLAISDT-LYVLSLPLLVYYYADENDWPFSEALCKIvrFLFYTNLYC--SILFLLCI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPL-FGWAQNVNDDKVC-------LISQDFGYTIYSTAVAF 248
Cdd:cd15373   95 SVHRFLGVCYPVRSLRWLKVRYARIVSVVVWVIVLACQSPVLyFVTTSDKGGNITChdtsspeLFDQFVVYSSVMLVLLF 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 249 YIPMSVMLFMYYQIYKaarksaakhkfpgfprvepdsvialngivklqkeveecanlsRLLKHERKNISIFKREQKAATT 328
Cdd:cd15373  175 CVPFVVILVCYALMVR------------------------------------------KLLKPSAGTSTNSRSKKKSVKM 212
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966963638 329 LGIIVGAFTVCWLPFFLLSTARPFICGTSCSC-------IPLWVERTflwLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15373  213 IIIVLAVFILCFLPFHVTRTLYYSFRSMDLSCgtlnainLAYKVTRP---LASANSCLDPILYFLAGQSFR 280
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
98-218 1.52e-03

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 40.35  E-value: 1.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWI----------FGHFFC----NVFIAMdv 163
Cdd:cd15917   17 GNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREIsfdaclaqmfFIHSFTamesGVLLAM-- 94
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 966963638 164 mcctasimtlcviSIDRYLGITRPLTYPVRQNGKCMAKMILSVwLLSASITLPPL 218
Cdd:cd15917   95 -------------AFDRYVAICYPLRYTTILTNTVVGKIGLAI-LLRAVALIIPL 135
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
97-219 1.64e-03

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 40.06  E-value: 1.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMP------FVSVTDLIGGKWIFGHFFCNVFIAMDvmcctaSI 170
Cdd:cd15952   16 LGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPkmlgifWFNLREISFGGCLAQMFFIHTFTGME------SA 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 966963638 171 MtLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLF 219
Cdd:cd15952   90 V-LVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVF 137
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
98-208 1.83e-03

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 40.01  E-value: 1.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMP-----FVSVTDLIGGKWIFGHFFCNVFIAmdvmccTASIMT 172
Cdd:cd15936   17 GNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPkmlsdLLSQTKTISFNGCMAQMFFFHFTG------GAEVFL 90
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 966963638 173 LCVISIDRYLGITRPLTYPVRQN-GKCMAkMILSVWL 208
Cdd:cd15936   91 LSVMAYDRYIAIHKPLHYLTIMNqGVCTG-LVAGSWL 126
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
152-231 2.46e-03

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 39.61  E-value: 2.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 152 HFFCNvfiamdvMCCTASIMtLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQ------NV 225
Cdd:cd15913   78 YFFFS-------LGTTECFF-LSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQlpfcgpNI 149

                 ....*.
gi 966963638 226 NDDKVC 231
Cdd:cd15913  150 IDHFLC 155
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
97-211 2.47e-03

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 39.46  E-value: 2.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWI------FGHFFcnvFIAMDVMCCtasi 170
Cdd:cd15421   16 TGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSIsfvgcgTQIFF---FLTLGGAEC---- 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 966963638 171 MTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSA 211
Cdd:cd15421   89 LLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGS 129
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
126-392 2.58e-03

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 39.38  E-value: 2.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 126 ADLSVAVaVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKcMAKMI-L 204
Cdd:cd15151   44 ADLIMTL-MLPFKILSDSGLGPWQLRAFVCRFSAVVFYITMYISIILLGLISFDRYLKIVRPFGKSWVQRVR-FAKILsG 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 205 SVWLLSASITLPPLFGWAQNVNDD---KVCLISQDFGY-----TIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKfp 276
Cdd:cd15151  122 AVWLVMFLLSVPNMILSNKPATPIsvkKCASLKSPLGLkwhevVNYICQFIFWGVFALMVLFYTIISKKVYESYKKSR-- 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638 277 gfprvepdsvialngivklqkeveecanlsrllkhERKNisifKREQKAATTLGIIVGAFTVCWLPFFLlsTARPFICGT 356
Cdd:cd15151  200 -----------------------------------SKDN----KASKKTKAKVFIIVAVFFVCFAPFHF--VRVPYTLSQ 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 966963638 357 SCSCIPLWVER-------TFLWLGYANSLINPFIYAFFNRDLR 392
Cdd:cd15151  239 TGKITDCQLQNllyiakeITLWLAATNVCLDPLIYIFLCKSFR 281
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
98-219 2.59e-03

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 39.41  E-value: 2.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638   98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGH------FFCNVFIAMDVMCCTAsim 171
Cdd:pfam13853  11 GNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEacltqmFFIHKFSIMESAVLLA--- 87
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 966963638  172 tlcvISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLF 219
Cdd:pfam13853  88 ----MAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPF 131
7TM_GPCR_Srsx pfam10320
Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis ...
98-215 2.65e-03

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 255903 [Multi-domain]  Cd Length: 257  Bit Score: 39.50  E-value: 2.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638   98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVsVTDLIGGKwiFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:pfam10320   7 GNVLMIHLTFRKKKLRSKCSILICVQCIAHLICLCGEIVFV-VLLFTGTQ--LTRNECFWMISFYIFGQTAQGPLMLMIG 83
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 966963638  178 IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITL 215
Cdd:pfam10320  84 IDRLIAVKFPIFYRLLSSSKYLFIQLIFPVIYSSFITV 121
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
97-219 2.99e-03

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 39.39  E-value: 2.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWI-FG-----HFFcnvFIAmdvmCCTASI 170
Cdd:cd13954   16 LGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTIsFSgcltqLYF---FFS----LGGTEC 88
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 966963638 171 MTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLF 219
Cdd:cd13954   89 FLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTV 137
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
98-208 3.04e-03

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 39.17  E-value: 3.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWI-FGHFFCNVFIAMdvMCCTASIMTLCVI 176
Cdd:cd15231   17 GNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTIsYIGCLAQLFFFV--SFVGTECLLLAVM 94
                         90       100       110
                 ....*....|....*....|....*....|..
gi 966963638 177 SIDRYLGITRPLTYPVRQNGKCMAKMILSVWL 208
Cdd:cd15231   95 AYDRYVAICNPLHYAVIMSRKVCLQLAAASWL 126
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
97-208 3.61e-03

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 38.97  E-value: 3.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  97 AGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDL-IGGKWI-FGHFFCNVFIAMDVMCCTASIMTlc 174
Cdd:cd15916   16 LGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLePGGKVIsFGGCVAQLYFFHFLGSTECFLYT-- 93
                         90       100       110
                 ....*....|....*....|....*....|....
gi 966963638 175 VISIDRYLGITRPLTYPVRQNGKCMAKMILSVWL 208
Cdd:cd15916   94 LMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWV 127
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
98-216 5.60e-03

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 38.31  E-value: 5.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGH------FFCNVFIAMDVMcctasim 171
Cdd:cd15956   17 GNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYvclsqmFLVHAFSAMESG------- 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 966963638 172 TLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLP 216
Cdd:cd15956   90 VLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIP 134
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
98-212 6.48e-03

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 38.31  E-value: 6.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966963638  98 GNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVsVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS 177
Cdd:cd15938   17 GNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKM-LVDFLSQRKAISYEACIAQLFFLHFVGAAEMFLLTVMA 95
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 966963638 178 IDRYLGITRPLTYPVRQNGKcmakmiLSVWLLSAS 212
Cdd:cd15938   96 YDRYVAICKPLHYTTIMSRR------LCWVLVAAS 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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