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Conserved domains on  [gi|966962076|ref|XP_015002438|]
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annexin A8 isoform X1 [Macaca mulatta]

Protein Classification

annexin( domain architecture ID 10446041)

annexin belongs to a family of calcium- and phospholipid-binding proteins that have been implicated in many cellular processes, including channel formation, membrane fusion, vesicle transport, and regulation of phospholipase A2 activity

CATH:  1.10.220.10
Gene Ontology:  GO:0005509|GO:0005544|GO:0048306|GO:0003723
PubMed:  15059252|1646719
SCOP:  4001063
TCDB:  1.A.31

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 26-90 1.52e-25

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 96.77  E-value: 1.52e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966962076   26 DAETLYKAMKGIGTNEQAIIDVLTKRSNAQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVAL 90
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 97-162 1.01e-24

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 94.85  E-value: 1.01e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966962076   97 YEAKELHDAMKGLGTKEGVIIEILASRTKNQLQEIMKAYEEDYGSSLEEDIQADTSGYLERILVCL 162
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 257-322 2.01e-23

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 91.38  E-value: 2.01e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966962076  257 YFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNLIKCHFKKMYGKTLSSMIMEDTSGDYKNALLSL 322
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 181-247 1.79e-18

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 77.90  E-value: 1.79e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966962076  181 QDAQDLYAAgEKIRGTDEMKFITILCTRSATHLLRVFEEYEKIANKSIEDSINSETHGSLEEAMLTV 247
Cdd:pfam00191   1 YDAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 26-90 1.52e-25

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 96.77  E-value: 1.52e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966962076   26 DAETLYKAMKGIGTNEQAIIDVLTKRSNAQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVAL 90
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 97-162 1.01e-24

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 94.85  E-value: 1.01e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966962076   97 YEAKELHDAMKGLGTKEGVIIEILASRTKNQLQEIMKAYEEDYGSSLEEDIQADTSGYLERILVCL 162
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 257-322 2.01e-23

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 91.38  E-value: 2.01e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966962076  257 YFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNLIKCHFKKMYGKTLSSMIMEDTSGDYKNALLSL 322
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
38-90 2.96e-20

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 82.46  E-value: 2.96e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 966962076    38 GTNEQAIIDVLTKRSNAQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVAL 90
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 181-247 1.79e-18

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 77.90  E-value: 1.79e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966962076  181 QDAQDLYAAgEKIRGTDEMKFITILCTRSATHLLRVFEEYEKIANKSIEDSINSETHGSLEEAMLTV 247
Cdd:pfam00191   1 YDAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
110-162 5.06e-18

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 76.29  E-value: 5.06e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 966962076   110 GTKEGVIIEILASRTKNQLQEIMKAYEEDYGSSLEEDIQADTSGYLERILVCL 162
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
270-322 1.23e-17

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 75.52  E-value: 1.23e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 966962076   270 GTRDGTLIRNIVSRSEIDLNLIKCHFKKMYGKTLSSMIMEDTSGDYKNALLSL 322
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
195-247 2.84e-15

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 68.97  E-value: 2.84e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 966962076   195 GTDEMKFITILCTRSATHLLRVFEEYEKIANKSIEDSINSETHGSLEEAMLTV 247
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 26-90 1.52e-25

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 96.77  E-value: 1.52e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966962076   26 DAETLYKAMKGIGTNEQAIIDVLTKRSNAQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVAL 90
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 97-162 1.01e-24

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 94.85  E-value: 1.01e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966962076   97 YEAKELHDAMKGLGTKEGVIIEILASRTKNQLQEIMKAYEEDYGSSLEEDIQADTSGYLERILVCL 162
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 257-322 2.01e-23

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 91.38  E-value: 2.01e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966962076  257 YFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNLIKCHFKKMYGKTLSSMIMEDTSGDYKNALLSL 322
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
38-90 2.96e-20

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 82.46  E-value: 2.96e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 966962076    38 GTNEQAIIDVLTKRSNAQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVAL 90
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 181-247 1.79e-18

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 77.90  E-value: 1.79e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966962076  181 QDAQDLYAAgEKIRGTDEMKFITILCTRSATHLLRVFEEYEKIANKSIEDSINSETHGSLEEAMLTV 247
Cdd:pfam00191   1 YDAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
110-162 5.06e-18

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 76.29  E-value: 5.06e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 966962076   110 GTKEGVIIEILASRTKNQLQEIMKAYEEDYGSSLEEDIQADTSGYLERILVCL 162
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
270-322 1.23e-17

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 75.52  E-value: 1.23e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 966962076   270 GTRDGTLIRNIVSRSEIDLNLIKCHFKKMYGKTLSSMIMEDTSGDYKNALLSL 322
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
195-247 2.84e-15

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 68.97  E-value: 2.84e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 966962076   195 GTDEMKFITILCTRSATHLLRVFEEYEKIANKSIEDSINSETHGSLEEAMLTV 247
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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