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Conserved domains on  [gi|1622963998|ref|XP_015001861|]
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aldo-keto reductase family 1 member C4 [Macaca mulatta]

Protein Classification

aldo-keto reductase family protein( domain architecture ID 305)

aldo-keto reductase family protein may be an NAD(P)(H) oxidoreductase that reduces aldehydes and ketones to primary and secondary alcohols

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AKR_SF super family cl00470
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
 6-211 3.62e-158

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


The actual alignment was detected with superfamily member cd19108:

Pssm-ID: 444925 [Multi-domain]  Cd Length: 303  Bit Score: 439.74  E-value: 3.62e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998   6 QRVELNDGHFMPVLGFGTYVPPE--------------------------------------------------------- 28
Cdd:cd19108     1 QRVKLNDGHFIPVLGFGTYAPEEvpkskaleatklaidagfrhidsaylyqneeevgqairskiadgtvkredifytskl 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  29 --------------------------------------PGETLLPKDENGKVIFDTVDLCAIWEAMEKCKDAGLAKSIGV 70
Cdd:cd19108    81 wctfhrpelvrpalekslkklqldyvdlylihfpvalkPGEELFPKDENGKLIFDTVDLCATWEAMEKCKDAGLAKSIGV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  71 SNFNRRQLEMILNNPGLKYKPVCNQVECHPYLNQSQLLDFCKSEDIVLVAHSALGTQRHKLWVDQNSPALLEDPVLCALA 150
Cdd:cd19108   161 SNFNRRQLEMILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAYSALGSQRDKEWVDQNSPVLLEDPVLCALA 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622963998 151 KKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQLTSEDMKVLDGLNGNFRYA 211
Cdd:cd19108   241 KKHKRTPALIALRYQLQRGVVVLAKSFNEKRIKENLQVFEFQLTSEDMKALDGLNRNLRYL 301
 
Name Accession Description Interval E-value
AKR_AKR1C1-35 cd19108
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ...
 6-211 3.62e-158

AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.


Pssm-ID: 381334 [Multi-domain]  Cd Length: 303  Bit Score: 439.74  E-value: 3.62e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998   6 QRVELNDGHFMPVLGFGTYVPPE--------------------------------------------------------- 28
Cdd:cd19108     1 QRVKLNDGHFIPVLGFGTYAPEEvpkskaleatklaidagfrhidsaylyqneeevgqairskiadgtvkredifytskl 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  29 --------------------------------------PGETLLPKDENGKVIFDTVDLCAIWEAMEKCKDAGLAKSIGV 70
Cdd:cd19108    81 wctfhrpelvrpalekslkklqldyvdlylihfpvalkPGEELFPKDENGKLIFDTVDLCATWEAMEKCKDAGLAKSIGV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  71 SNFNRRQLEMILNNPGLKYKPVCNQVECHPYLNQSQLLDFCKSEDIVLVAHSALGTQRHKLWVDQNSPALLEDPVLCALA 150
Cdd:cd19108   161 SNFNRRQLEMILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAYSALGSQRDKEWVDQNSPVLLEDPVLCALA 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622963998 151 KKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQLTSEDMKVLDGLNGNFRYA 211
Cdd:cd19108   241 KKHKRTPALIALRYQLQRGVVVLAKSFNEKRIKENLQVFEFQLTSEDMKALDGLNRNLRYL 301
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 45-221 2.62e-62

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 194.89  E-value: 2.62e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  45 DTVDLCAI-----------WEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPGlkYKPVCNQVECHPYLNQSQLLDFCKS 113
Cdd:COG0656    91 DYLDLYLIhwpgpgpyvetWRALEELYEEGLIRAIGVSNFDPEHLEELLAETG--VKPAVNQVELHPYLQQRELLAFCRE 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 114 EDIVLVAHSALGtqrhklwvdqnSPALLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQL 193
Cdd:COG0656   169 HGIVVEAYSPLG-----------RGKLLDDPVLAEIAEKHGKTPAQVVLRWHLQRGVVVIPKSVTPERIRENLDAFDFEL 237

                         170       180
                  ....*....|....*....|....*...
gi 1622963998 194 TSEDMKVLDGLNGNFRYAVmdflvdHPD 221
Cdd:COG0656   238 SDEDMAAIDALDRGERLGP------DPD 259
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 46-205 1.50e-37

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 132.44  E-value: 1.50e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  46 TVDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPglKYKPVCNQVECHPY--LNQSQLLDFCKSEDIVLVAHSA 123
Cdd:pfam00248 113 DTPIEETWDALEELKKEGKIRAIGVSNFDAEQIEKALTKG--KIPIVAVQVEYNLLrrRQEEELLEYCKKNGIPLIAYSP 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 124 LG----------------TQRHKLWVDQNSPALLEDPVLCALAKKHKPSPALIALRY--QLQRGVVVLAKSYNEQRIREN 185
Cdd:pfam00248 191 LGgglltgkytrdpdkgpGERRRLLKKGTPLNLEALEALEEIAKEHGVSPAQVALRWalSKPGVTIPIPGASNPEQLEDN 270

                         170       180
                  ....*....|....*....|
gi 1622963998 186 VQVFEFQLTSEDMKVLDGLN 205
Cdd:pfam00248 271 LGALEFPLSDEEVARIDELL 290
dkgA PRK11565
2,5-didehydrogluconate reductase DkgA;
53-198 2.35e-27

2,5-didehydrogluconate reductase DkgA;


Pssm-ID: 183203 [Multi-domain]  Cd Length: 275  Bit Score: 105.15  E-value: 2.35e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  53 WEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPGLKykPVCNQVECHPYLNQSQLLDFCKSEDIVLVAHSALGtqrhklw 132
Cdd:PRK11565  120 WKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT--PVINQIELHPLMQQRQLHAWNATHKIQTESWSPLA------- 190

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622963998 133 vdQNSPALLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQLTSEDM 198
Cdd:PRK11565  191 --QGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVFDFRLDKDEL 254
 
Name Accession Description Interval E-value
AKR_AKR1C1-35 cd19108
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ...
 6-211 3.62e-158

AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.


Pssm-ID: 381334 [Multi-domain]  Cd Length: 303  Bit Score: 439.74  E-value: 3.62e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998   6 QRVELNDGHFMPVLGFGTYVPPE--------------------------------------------------------- 28
Cdd:cd19108     1 QRVKLNDGHFIPVLGFGTYAPEEvpkskaleatklaidagfrhidsaylyqneeevgqairskiadgtvkredifytskl 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  29 --------------------------------------PGETLLPKDENGKVIFDTVDLCAIWEAMEKCKDAGLAKSIGV 70
Cdd:cd19108    81 wctfhrpelvrpalekslkklqldyvdlylihfpvalkPGEELFPKDENGKLIFDTVDLCATWEAMEKCKDAGLAKSIGV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  71 SNFNRRQLEMILNNPGLKYKPVCNQVECHPYLNQSQLLDFCKSEDIVLVAHSALGTQRHKLWVDQNSPALLEDPVLCALA 150
Cdd:cd19108   161 SNFNRRQLEMILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAYSALGSQRDKEWVDQNSPVLLEDPVLCALA 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622963998 151 KKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQLTSEDMKVLDGLNGNFRYA 211
Cdd:cd19108   241 KKHKRTPALIALRYQLQRGVVVLAKSFNEKRIKENLQVFEFQLTSEDMKALDGLNRNLRYL 301
AKR_AKR1D1-3 cd19109
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ...
 28-224 3.91e-114

AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.


Pssm-ID: 381335 [Multi-domain]  Cd Length: 308  Bit Score: 328.68  E-value: 3.91e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  28 EPGETLLPKDENGKVIFDTVDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPGLKYKPVCNQVECHPYLNQSQL 107
Cdd:cd19109   112 KPGDEIYPRDENGKWLYHKTNLCATWEALEACKDAGLVKSIGVSNFNRRQLELILNKPGLKHKPVSNQVECHPYFTQPKL 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 108 LDFCKSEDIVLVAHSALGTQRHKLWVDQNSPALLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQ 187
Cdd:cd19109   192 LEFCQQHDIVIVAYSPLGTCRDPIWVNVSSPPLLEDPLLNSIGKKYNKTAAQVVLRFNIQRGVVVIPKSFNPERIKENFQ 271

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1622963998 188 VFEFQLTSEDMKVLDGLNGNFRYAVMDFLVDHPDYPF 224
Cdd:cd19109   272 IFDFSLTEEEMKDIEALNKNVRYVELLMWRDHPEYPF 308
AKR_AKR1B1-19 cd19107
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ...
 28-228 1.84e-80

AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.


Pssm-ID: 381333 [Multi-domain]  Cd Length: 307  Bit Score: 243.09  E-value: 1.84e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  28 EPGETLLPKDENGKVIFDTVDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPGLKYKPVCNQVECHPYLNQSQL 107
Cdd:cd19107   108 KPGKELFPLDESGNVIPSDTTFLDTWEAMEELVDEGLVKAIGVSNFNHLQIERILNKPGLKYKPAVNQIECHPYLTQEKL 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 108 LDFCKSEDIVLVAHSALGTQrHKLWVDQNSPALLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQ 187
Cdd:cd19107   188 IQYCQSKGIVVTAYSPLGSP-DRPWAKPEDPSLLEDPKIKEIAAKHNKTTAQVLIRFPIQRNLVVIPKSVTPERIAENFK 266

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1622963998 188 VFEFQLTSEDMKVLDGLNGNFRYAVMDFLVDHPDYPFSDEY 228
Cdd:cd19107   267 VFDFELSSEDMATILSFNRNWRACALLSCSSHKDYPFHAEY 307
AKR_AKR1A1-4 cd19106
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ...
 28-218 9.15e-77

AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.


Pssm-ID: 381332 [Multi-domain]  Cd Length: 305  Bit Score: 233.43  E-value: 9.15e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  28 EPGETLLPKDENGKVIFDTVDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPglKYKPVCNQVECHPYLNQSQL 107
Cdd:cd19106   112 ERGDNPFPKNPDGTIRYDSTHYKETWKAMEKLVDKGLVKAIGLSNFNSRQIDDILSVA--RIKPAVLQVECHPYLAQNEL 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 108 LDFCKSEDIVLVAHSALGTQrHKLWVDQNSPALLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQ 187
Cdd:cd19106   190 IAHCKARGLVVTAYSPLGSP-DRPWAKPDEPVLLEEPKVKALAKKYNKSPAQILLRWQVQRGVVVIPKSVTPSRIKQNIQ 268

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1622963998 188 VFEFQLTSEDMKVLDGLNGNFRYAVMDFLVD 218
Cdd:cd19106   269 VFDFTLSPEEMKQLDALNRNWRYIVPMITVD 299
AKR_AKR1E1-2 cd19110
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ...
 28-228 7.35e-72

AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.


Pssm-ID: 381336 [Multi-domain]  Cd Length: 301  Bit Score: 220.99  E-value: 7.35e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  28 EPGETLLPKDENGKVIFDTVDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPGLKYKPVCNQVECHPYLNQSQL 107
Cdd:cd19110   108 KPGEPDLPLDRSGMVIPSDTDFLDTWEAMEDLVIEGLVKNIGVSNFNHEQLERLLNKPGLRVKPVTNQIECHPYLTQKKL 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 108 LDFCKSEDIVLVAHSALGTQRHKLwvdqnspALLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQ 187
Cdd:cd19110   188 ISFCQSRNVSVTAYRPLGGSCEGV-------DLIDDPVIQRIAKKHGKSPAQILIRFQIQRNVIVIPKSVTPSRIKENIQ 260

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1622963998 188 VFEFQLTSEDMKVLDGLNGNFRYAVMDFLVDHPDYPFSDEY 228
Cdd:cd19110   261 VFDFELTEHDMDNLLSLDRNLRLATFPITENHKDYPFHIEY 301
AKR_AKR1-5-like cd19071
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...
 40-202 1.38e-66

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.


Pssm-ID: 381297 [Multi-domain]  Cd Length: 251  Bit Score: 205.79  E-value: 1.38e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  40 GKVIFDTVDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPglKYKPVCNQVECHPYLNQSQLLDFCKSEDIVLV 119
Cdd:cd19071   100 GKEGGSKEARLETWRALEELVDEGLVRSIGVSNFNVEHLEELLAAA--RIKPAVNQIELHPYLQQKELVEFCKEHGIVVQ 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 120 AHSALGTQRHKLwvdqnspalLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQLTSEDMK 199
Cdd:cd19071   178 AYSPLGRGRRPL---------LDDPVLKEIAKKYGKTPAQVLLRWALQRGVVVIPKSSNPERIKENLDVFDFELSEEDMA 248


                  ...
gi 1622963998 200 VLD 202
Cdd:cd19071   249 AID 251
AKR_AKR2E1-5 cd19116
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ...
 37-210 4.35e-63

AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.


Pssm-ID: 381342 [Multi-domain]  Cd Length: 292  Bit Score: 198.28  E-value: 4.35e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  37 DENGKVIFDTVDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPglKYKPVCNQVECHPYLNQSQLLDFCKSEDI 116
Cdd:cd19116   122 ESNGDGSLSDIDYLETWRGMEDLVKLGLTRSIGVSNFNSEQINRLLSNC--NIKPAVNQIEVHPTLTQEKLVAYCQSNGI 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 117 VLVAHSALGtqRHKLWVDQNSPALLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQLTSE 196
Cdd:cd19116   200 VVMAYSPFG--RLVPRGQTNPPPRLDDPTLVAIAKKYGKTTAQIVLRYLIDRGVVPIPKSSNKKRIKENIDIFDFQLTPE 277

                         170
                  ....*....|....
gi 1622963998 197 DMKVLDGLNGNFRY 210
Cdd:cd19116   278 EVAALNSFNTNQRV 291
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 45-221 2.62e-62

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 194.89  E-value: 2.62e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  45 DTVDLCAI-----------WEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPGlkYKPVCNQVECHPYLNQSQLLDFCKS 113
Cdd:COG0656    91 DYLDLYLIhwpgpgpyvetWRALEELYEEGLIRAIGVSNFDPEHLEELLAETG--VKPAVNQVELHPYLQQRELLAFCRE 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 114 EDIVLVAHSALGtqrhklwvdqnSPALLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQL 193
Cdd:COG0656   169 HGIVVEAYSPLG-----------RGKLLDDPVLAEIAEKHGKTPAQVVLRWHLQRGVVVIPKSVTPERIRENLDAFDFEL 237

                         170       180
                  ....*....|....*....|....*...
gi 1622963998 194 TSEDMKVLDGLNGNFRYAVmdflvdHPD 221
Cdd:COG0656   238 SDEDMAAIDALDRGERLGP------DPD 259
AKR_AKR1G1_CeAKR cd19154
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ...
 37-205 1.63e-59

Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381380 [Multi-domain]  Cd Length: 303  Bit Score: 189.55  E-value: 1.63e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  37 DENGKVIFDTVDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPglKYKPVCNQVECHPYLNQSQLLDFCKSEDI 116
Cdd:cd19154   125 MENGMSIHDAVDVEDVWRGMEKVYDEGLTKAIGVSNFNNDQIQRILDNA--RVKPHNNQVECHLYFPQKELVEFCKKHNI 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 117 VLVAHSALGTQRHKLWV----DQNSPALLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQ 192
Cdd:cd19154   203 SVTSYATLGSPGRANFTkstgVSPAPNLLQDPIVKAIAEKHGKTPAQVLLRYLLQRGIAVIPKSATPSRIKENFNIFDFS 282

                         170
                  ....*....|...
gi 1622963998 193 LTSEDMKVLDGLN 205
Cdd:cd19154   283 LSEEDMATLEEIE 295
AKR_AKR1I_CgAKR1 cd19155
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ...
 37-209 9.57e-57

Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381381 [Multi-domain]  Cd Length: 307  Bit Score: 182.34  E-value: 9.57e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  37 DENGKVIFD-TVDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPglKYKPVCNQVECHPYLNQSQLLDFCKSED 115
Cdd:cd19155   126 DPTGEHKQDyTTDLLDIWKAMEAQVDQGLTRSIGLSNFNREQMARILKNA--RIKPANLQVELHVYLQQKDLVDFCSTHS 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 116 IVLVAHSALGTQ-RHKLW-----VDQNSPALLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVF 189
Cdd:cd19155   204 ITVTAYAPLGSPgAAHFSpgtgsPSGSSPDLLQDPVVKAIAERHGKSPAQVLLRWLMQRGVVVIPKSTNAARIKENFQVF 283

                         170       180
                  ....*....|....*....|
gi 1622963998 190 EFQLTSEDMKVLDGLNGNFR 209
Cdd:cd19155   284 DFELTEADMAKLSSLDKNIR 303
AKR_AKR3G1 cd19123
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ...
 33-210 6.33e-56

AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.


Pssm-ID: 381349 [Multi-domain]  Cd Length: 297  Bit Score: 179.91  E-value: 6.33e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  33 LLPKDENGKVIFDTVDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPglKYKPVCNQVECHPYLNQSQLLDFCK 112
Cdd:cd19123   120 GFPESGEDLLSLSPIPLEDTWRAMEELVDKGLCRHIGVSNFSVKKLEDLLATA--RIKPAVNQVELHPYLQQPELLAFCR 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 113 SEDIVLVAHSALGT-QRHKLWVDQNSPALLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEF 191
Cdd:cd19123   198 DNGIHLTAYSPLGSgDRPAAMKAEGEPVLLEDPVINKIAEKHGASPAQVLIAWAIQRGTVVIPKSVNPERIQQNLEAAEV 277

                         170
                  ....*....|....*....
gi 1622963998 192 QLTSEDMKVLDGLNGNFRY 210
Cdd:cd19123   278 ELDASDMATIAALDRHHRY 296
AKR_AKR4C1-15 cd19125
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ...
 35-204 1.55e-50

AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.


Pssm-ID: 381351 [Multi-domain]  Cd Length: 287  Bit Score: 165.98  E-value: 1.55e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  35 PKDENGKVIfdTVDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPglKYKPVCNQVECHPYLNQSQLLDFCKSE 114
Cdd:cd19125   119 HMPEPEEVL--PPDIPSTWKAMEKLVDSGKVRAIGVSNFSVKKLEDLLAVA--RVPPAVNQVECHPGWQQDKLHEFCKSK 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 115 DIVLVAHSALGTQrHKLWVDQNspaLLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQLT 194
Cdd:cd19125   195 GIHLSAYSPLGSP-GTTWVKKN---VLKDPIVTKVAEKLGKTPAQVALRWGLQRGTSVLPKSTNEERIKENIDVFDWSIP 270

                         170
                  ....*....|
gi 1622963998 195 SEDMKVLDGL 204
Cdd:cd19125   271 EEDFAKFSSI 280
AKR_DrGR-like cd19136
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ...
 53-204 1.61e-49

Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).


Pssm-ID: 381362 [Multi-domain]  Cd Length: 262  Bit Score: 162.42  E-value: 1.61e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  53 WEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPglKYKPVCNQVECHPYLNQSQLLDFCKSEDIVLVAHSALGTQRhklw 132
Cdd:cd19136   122 WRALEDLYKEGKLRAIGVSNYTVRHLEELLKYC--EVPPAVNQVEFHPHLVQKELLKFCKDHGIHLQAYSSLGSGD---- 195

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622963998 133 vdqnsPALLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQLTSEDMKVLDGL 204
Cdd:cd19136   196 -----LRLLEDPTVLAIAKKYGRTPAQVLLRWALQQGIGVIPKSTNPERIAENIKVFDFELSEEDMAELNAL 262
AKR_AKR1G1_1I cd19111
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ...
 36-210 2.81e-49

Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381337 [Multi-domain]  Cd Length: 286  Bit Score: 162.67  E-value: 2.81e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  36 KDENGKVIFDTVDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPglKYKPVCNQVECHPYLNQSQLLDFCKSED 115
Cdd:cd19111   110 KKDKGERELASSDVTSVWRAMEALVSEGKVKSIGLSNFNPRQINKILAYA--KVKPSNLQLECHAYLQQRELRKFCNKKN 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 116 IVLVAHSALGT---QRHKLWVDQnsPALLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQ 192
Cdd:cd19111   188 IVVTAYAPLGSpgrANQSLWPDQ--PDLLEDPTVLAIAKELDKTPAQVLLRFVLQRGTGVLPKSTNKERIEENFEVFDFE 265

                         170
                  ....*....|....*...
gi 1622963998 193 LTSEDMKVLDGLNGNFRY 210
Cdd:cd19111   266 LTEEHFKKLKTLDRNMKY 283
AKR_AKR4A_4B cd19124
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ...
 14-204 6.60e-49

AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.


Pssm-ID: 381350 [Multi-domain]  Cd Length: 281  Bit Score: 161.67  E-value: 6.60e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  14 HFmPV-LGFGTYVPPEPGETLLPkdengkvifdtVDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPglKYKPV 92
Cdd:cd19124   106 HW-PVsLKPGKFSFPIEEEDFLP-----------FDIKGVWEAMEECQRLGLTKAIGVSNFSCKKLQELLSFA--TIPPA 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  93 CNQVECHPYLNQSQLLDFCKSEDIVLVAHSALGTQRHKlWvdqNSPALLEDPVLCALAKKHKPSPALIALRYQLQRGVVV 172
Cdd:cd19124   172 VNQVEMNPAWQQKKLREFCKANGIHVTAYSPLGAPGTK-W---GSNAVMESDVLKEIAAAKGKTVAQVSLRWVYEQGVSL 247

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1622963998 173 LAKSYNEQRIRENVQVFEFQLTSEDMKVLDGL 204
Cdd:cd19124   248 VVKSFNKERMKQNLDIFDWELTEEDLEKISEI 279
AKR_AKR3F2_3 cd19073
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ...
 45-202 8.50e-48

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381299 [Multi-domain]  Cd Length: 243  Bit Score: 157.43  E-value: 8.50e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  45 DTVDLCAI-W-----------EAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPGLKykPVCNQVECHPYLNQSQLLDFCK 112
Cdd:cd19073    87 DYVDLLLIhWpnptvpleetlGALKELKEAGKVKSIGVSNFTIELLEEALDISPLP--IAVNQVEFHPFLYQAELLEYCR 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 113 SEDIVLVAHSALGtqRHKLwvdqnspalLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQ 192
Cdd:cd19073   165 ENDIVITAYSPLA--RGEV---------LRDPVIQEIAEKYDKTPAQVALRWLVQKGIVVIPKASSEDHLKENLAIFDWE 233

                         170
                  ....*....|
gi 1622963998 193 LTSEDMKVLD 202
Cdd:cd19073   234 LTSEDVAKID 243
AKR_AKR2A1-2 cd19112
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ...
 43-210 1.44e-47

AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.


Pssm-ID: 381338 [Multi-domain]  Cd Length: 308  Bit Score: 158.80  E-value: 1.44e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  43 IFDTVDLCAIWEAMEKCKDAGLAKSIGVSNFnrrqlEMILNNPGLKY---KPVCNQVECHPYLNQSQLLDFCKSEDIVLV 119
Cdd:cd19112   132 IDVTISLETTWHAMEKLVSAGLVRSIGISNY-----DIFLTRDCLAYskiKPAVNQIETHPYFQRDSLVKFCQKHGISVT 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 120 AHSALG-TQRHKLWVDQNSPalLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQLTSEDM 198
Cdd:cd19112   207 AHTPLGgAAANAEWFGSVSP--LDDPVLKDLAKKYGKSAAQIVLRWGIQRNTAVIPKSSKPERLKENIDVFDFQLSKEDM 284

                         170
                  ....*....|..
gi 1622963998 199 KVLDGLNGNFRY 210
Cdd:cd19112   285 KLIKSLDRKYRT 296
AKR_AKR3C2-3 cd19120
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ...
 45-202 3.68e-47

Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.


Pssm-ID: 381346 [Multi-domain]  Cd Length: 269  Bit Score: 156.62  E-value: 3.68e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  45 DTVDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPglKYKPVCNQVECHPYLN--QSQLLDFCKSEDIVLVAHS 122
Cdd:cd19120   111 GGPTLAEAWAELEALKDAGLVRSIGVSNFRIEDLEELLDTA--KIKPAVNQIEFHPYLYpqQPALLEYCREHGIVVSAYS 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 123 ALGTqrhkLWVDQNSPAlleDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQLTSEDMKVLD 202
Cdd:cd19120   189 PLSP----LTRDAGGPL---DPVLEKIAEKYGVTPAQVLLRWALQKGIVVVTTSSKEERMKEYLEAFDFELTEEEVEEID 261
AKR_AKR5A_5G cd19126
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ...
 53-205 1.33e-46

AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381352 [Multi-domain]  Cd Length: 254  Bit Score: 154.90  E-value: 1.33e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  53 WEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPglKYKPVCNQVECHPYLNQSQLLDFCKSEDIVLVAHSALGtQRHklw 132
Cdd:cd19126   115 WKALEKLYASGKVKAIGVSNFQEHHLEELLAHA--DVVPAVNQVEFHPYLTQKELRGYCKSKGIVVEAWSPLG-QGG--- 188

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622963998 133 vdqnspaLLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQLTSEDMKVLDGLN 205
Cdd:cd19126   189 -------LLSNPVLAAIGEKYGKSAAQVVLRWDIQHGVVTIPKSVHASRIKENADIFDFELSEDDMTAIDALN 254
AKR_AKR5G1-3 cd19157
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ...
 53-210 7.03e-46

AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381383 [Multi-domain]  Cd Length: 265  Bit Score: 153.32  E-value: 7.03e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  53 WEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPglKYKPVCNQVECHPYLNQSQLLDFCKSEDIVLVAHSALGTQRhklw 132
Cdd:cd19157   116 WKALEKLYKDGRVRAIGVSNFQVHHLEDLLADA--EIVPMVNQVEFHPRLTQKELRDYCKKQGIQLEAWSPLMQGQ---- 189

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622963998 133 vdqnspaLLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQLTSEDMKVLDGLNGNFRY 210
Cdd:cd19157   190 -------LLDNPVLKEIAEKYNKSVAQVILRWDLQNGVVTIPKSIKEHRIIENADVFDFELSQEDMDKIDALNENLRV 260
AKR_AKR5F1 cd19133
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ...
 8-205 1.12e-45

the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381359 [Multi-domain]  Cd Length: 255  Bit Score: 152.34  E-value: 1.12e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998   8 VELNDGHFMPVLGFGTYVPPEPGET----------------------------------------------LLPKD---E 38
Cdd:cd19133     1 VTLNNGVEMPILGFGVFQIPDPEECeravleaikagyrlidtaaaygneeavgraikksgipreelfittkLWIQDagyE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  39 NGKVIFDT---------VDLCAI----------WEAMEKCKDAGLAKSIGVSNFNRRQL-EMILNNpglKYKPVCNQVEC 98
Cdd:cd19133    81 KAKKAFERslkrlgldyLDLYLIhqpfgdvygaWRAMEELYKEGKIRAIGVSNFYPDRLvDLILHN---EVKPAVNQIET 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  99 HPYLNQSQLLDFCKSEDIVLVAHSALGTQRhklwvdqnsPALLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYN 178
Cdd:cd19133   158 HPFNQQIEAVEFLKKYGVQIEAWGPFAEGR---------NNLFENPVLTEIAEKYGKSVAQVILRWLIQRGIVVIPKSVR 228

                         250       260
                  ....*....|....*....|....*..
gi 1622963998 179 EQRIRENVQVFEFQLTSEDMKVLDGLN 205
Cdd:cd19133   229 PERIAENFDIFDFELSDEDMEAIAALD 255
AKR_AKR2D1 cd19115
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ...
 24-210 7.47e-45

AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.


Pssm-ID: 381341 [Multi-domain]  Cd Length: 311  Bit Score: 151.80  E-value: 7.47e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  24 YVPPE----PGEtllpKDENGKVIFDTVDLCAIWEAMEKCKDAGLAKSIGVSNFNRrQLEMILnnpgLKY---KPVCNQV 96
Cdd:cd19115   118 YVDPAvrypPGW----FYDGKKVEFSNAPIQETWTAMEKLVDKGLARSIGVSNFSA-QLLMDL----LRYariRPATLQI 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  97 ECHPYLNQSQLLDFCKSEDIVLVAHSALGTQRH-KLWVDQ--NSPALLEDPVLCALAKKHKPSPALIALRYQLQRGVVVL 173
Cdd:cd19115   189 EHHPYLTQPRLVKYAQKEGIAVTAYSSFGPQSFlELDLPGakDTPPLFEHDVIKSIAEKHGKTPAQVLLRWATQRGIAVI 268

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1622963998 174 AKSYNEQRIRENVQVFEFQLTSEDMKVLDGLNGNFRY 210
Cdd:cd19115   269 PKSNNPKRLAQNLDVTGFDLEAEEIKAISALDIGLRF 305
AKR_AKR5C2 cd19131
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ...
 8-205 2.67e-44

Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.


Pssm-ID: 381357 [Multi-domain]  Cd Length: 256  Bit Score: 149.06  E-value: 2.67e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998   8 VELNDGHFMPVLGFGTY-VPPEPGETL--------------------------------LPKDE--------NG------ 40
Cdd:cd19131     2 ITLNDGNTIPQLGLGVWqVSNDEAASAvrealevgyrsidtaaiygneegvgkairasgVPREElfittklwNSdqgyds 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  41 ----------KVIFDTVDLCAI-------------WEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPGLKykPVCNQVE 97
Cdd:cd19131    82 tlrafdeslrKLGLDYVDLYLIhwpvpaqdkyvetWKALIELKKEGRVKSIGVSNFTIEHLQRLIDETGVV--PVVNQIE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  98 CHPYLNQSQLLDFCKSEDIVLVAHSALGTQRhklwvdqnspaLLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSY 177
Cdd:cd19131   160 LHPRFQQRELRAFHAKHGIQTESWSPLGQGG-----------LLSDPVIGEIAEKHGKTPAQVVIRWHLQNGLVVIPKSV 228

                         250       260
                  ....*....|....*....|....*...
gi 1622963998 178 NEQRIRENVQVFEFQLTSEDMKVLDGLN 205
Cdd:cd19131   229 TPSRIAENFDVFDFELDADDMQAIAGLD 256
AKR_AKR3A1-2 cd19117
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ...
 25-204 1.03e-43

AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.


Pssm-ID: 381343 [Multi-domain]  Cd Length: 284  Bit Score: 148.42  E-value: 1.03e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  25 VPPEP-GETLLPKDENG-KVIFDTVDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPGLKYKPVCNQVECHPYL 102
Cdd:cd19117   109 VPLDPdGNDFLFKKDDGtKDHEPDWDFIKTWELMQKLPATGKVKAIGVSNFSIKNLEKLLASPSAKIVPAVNQIELHPLL 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 103 NQSQLLDFCKSEDIVLVAHSALGTqrhklwvdQNSPaLLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRI 182
Cdd:cd19117   189 PQPKLVDFCKSKGIHATAYSPLGS--------TNAP-LLKEPVIIKIAKKHGKTPAQVIISWGLQRGYSVLPKSVTPSRI 259

                         170       180
                  ....*....|....*....|..
gi 1622963998 183 RENVQVFEfqLTSEDMKVLDGL 204
Cdd:cd19117   260 ESNFKLFT--LSDEEFKEIDEL 279
AKR_AKR5A1_2 cd19156
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ...
 41-210 9.81e-43

AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.


Pssm-ID: 381382 [Multi-domain]  Cd Length: 266  Bit Score: 145.35  E-value: 9.81e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  41 KVIFDTVDLCAI-----------WEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNpgLKYKPVCNQVECHPYLNQSQLLD 109
Cdd:cd19156    92 KLGLDYVDLYLIhwpvkgkfkdtWKAFEKLYKEKKVRAIGVSNFHEHHLEELLKS--CKVAPMVNQIELHPLLTQEPLRK 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 110 FCKSEDIVLVAHSALGTQRhklwvdqnspaLLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVF 189
Cdd:cd19156   170 FCKEKNIAVEAWSPLGQGK-----------LLSNPVLKAIGKKYGKSAAQVIIRWDIQHGIITIPKSVHEERIQENFDVF 238

                         170       180
                  ....*....|....*....|.
gi 1622963998 190 EFQLTSEDMKVLDGLNGNFRY 210
Cdd:cd19156   239 DFELTAEEIRQIDGLNTDHRY 259
AKR_AKR5D1_E1 cd19132
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ...
 53-205 2.91e-42

AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381358 [Multi-domain]  Cd Length: 255  Bit Score: 143.56  E-value: 2.91e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  53 WEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPGLKykPVCNQVECHPYLNQSQLLDFCKSEDIVLVAHSALGtqrhklw 132
Cdd:cd19132   114 WQALIEAREEGLVRSIGVSNFLPEHLDRLIDETGVT--PAVNQIELHPYFPQAEQRAYHREHGIVTQSWSPLG------- 184

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622963998 133 vdQNSpALLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQLTSEDMKVLDGLN 205
Cdd:cd19132   185 --RGS-GLLDEPVIKAIAEKHGKTPAQVVLRWHVQLGVVPIPKSANPERQRENLAIFDFELSDEDMAAIAALD 254
AKR_CeZK1290-like cd19135
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ...
 53-204 4.07e-41

Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381361 [Multi-domain]  Cd Length: 265  Bit Score: 140.92  E-value: 4.07e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  53 WEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPGLKykPVCNQVECHPYLNQSQLLDFCKSEDIVLVAHSALGTQRhklw 132
Cdd:cd19135   126 WRALEELYDEGLCRAIGVSNFLIEHLEQLLEDCSVV--PHVNQVEFHPFQNPVELIEYCRDNNIVFEGYCPLAKGK---- 199

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622963998 133 vdqnspaLLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQLTSEDMKVLDGL 204
Cdd:cd19135   200 -------ALEEPTVTELAKKYQKTPAQILIRWSIQNGVVTIPKSTKEERIKENCQVFDFSLSEEDMATLDSL 264
AKR_AKR2B1-10 cd19113
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ...
 41-210 5.15e-41

AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.


Pssm-ID: 381339 [Multi-domain]  Cd Length: 310  Bit Score: 141.81  E-value: 5.15e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  41 KVIFDTVDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNnpGLKYKPVCNQVECHPYLNQSQLLDFCKSEDIVLVA 120
Cdd:cd19113   134 NFVYEDVPILDTWKALEKLVDAGKIKSIGVSNFPGALILDLLR--GATIKPAVLQIEHHPYLQQPKLIEYAQKAGITITA 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 121 HSALGTQRHkLWVDQ----NSPALLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQLTSE 196
Cdd:cd19113   212 YSSFGPQSF-VELNQgralNTPTLFEHDTIKSIAAKHNKTPAQVLLRWATQRGIAVIPKSNLPERLLQNLSVNDFDLTKE 290

                         170
                  ....*....|....
gi 1622963998 197 DMKVLDGLNGNFRY 210
Cdd:cd19113   291 DFEEIAKLDIGLRF 304
AKR_AKR3F3 cd19140
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ...
 45-204 2.21e-40

Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381366 [Multi-domain]  Cd Length: 253  Bit Score: 138.55  E-value: 2.21e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  45 DTVDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPGLKYkpVCNQVECHPYLNQSQLLDFCKSEDIVLVAHSAL 124
Cdd:cd19140   106 KDVPLAETLGALNEAQEAGLARHIGVSNFTVALLREAVELSEAPL--FTNQVEYHPYLDQRKLLDAAREHGIALTAYSPL 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 125 GTQRhklwvdqnspaLLEDPVLCALAKKHKPSPALIALRYQLQR-GVVVLAKSYNEQRIRENVQVFEFQLTSEDMKVLDG 203
Cdd:cd19140   184 ARGE-----------VLKDPVLQEIGRKHGKTPAQVALRWLLQQeGVAAIPKATNPERLEENLDIFDFTLSDEEMARIAA 252


                  .
gi 1622963998 204 L 204
Cdd:cd19140   253 L 253
AKR_AKR3D1 cd19121
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ...
 27-204 4.14e-40

AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.


Pssm-ID: 381347 [Multi-domain]  Cd Length: 279  Bit Score: 138.82  E-value: 4.14e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  27 PEPGETLLPKDENGKVIFD-TVDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILnnPGLKYKPVCNQVECHPYLNQS 105
Cdd:cd19121   114 PNGNHDLFPTLPDGSRDLDwDWNHVDTWKQMEKVLKTGKTKAIGVSNYSIPYLEELL--KHATVVPAVNQVENHPYLPQQ 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 106 QLLDFCKSEDIVLVAHSALGTQrhklwvdqNSPaLLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIREN 185
Cdd:cd19121   192 ELVDFCKEKGILIEAYSPLGST--------GSP-LISDEPVVEIAKKHNVGPGTVLISYQVARGAVVLPKSVTPDRIKSN 262

                         170
                  ....*....|....*....
gi 1622963998 186 VQVFEFqlTSEDMKVLDGL 204
Cdd:cd19121   263 LEIIDL--DDEDMNKLNDI 279
AKR_BaDH-like cd19129
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ...
 28-188 9.41e-40

Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.


Pssm-ID: 381355 [Multi-domain]  Cd Length: 295  Bit Score: 138.36  E-value: 9.41e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  28 EPGETLLPKDENGKVIFDT-VDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPglKYKPVCNQVECHPYLNQSQ 106
Cdd:cd19129   110 QPGDEQDPRDANGNVIYDDgVTLLDTWRAMERLVDEGRCKAIGLSDVSLEKLREIFEAA--RIKPAVVQVESHPYLPEWE 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 107 LLDFCKSEDIVLVAHSALGtqrHKLwvdqnSPALLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENV 186
Cdd:cd19129   188 LLDFCKNHGIVLQAFAPLG---HGM-----EPKLLEDPVITAIARRVNKTPAQVLLAWAIQRGTALLTTSKTPSRIRENF 259


                  ..
gi 1622963998 187 QV 188
Cdd:cd19129   260 DI 261
AKR_AKR3B1-3 cd19118
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ...
 26-204 2.10e-39

AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.


Pssm-ID: 381344 [Multi-domain]  Cd Length: 283  Bit Score: 137.16  E-value: 2.10e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  26 PPEPGETLLP--KDENGKVIFDT-VDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPGLKykPVCNQVECHPYL 102
Cdd:cd19118   112 KPTGDLNPLTavPTNGGEVDLDLsVSLVDTWKAMVELKKTGKVKSIGVSNFSIDHLQAIIEETGVV--PAVNQIEAHPLL 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 103 NQSQLLDFCKSEDIVLVAHSALGTQRhklwvdQNSPALLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRI 182
Cdd:cd19118   190 LQDELVDYCKSKNIHITAYSPLGNNL------AGLPLLVQHPEVKAIAAKLGKTPAQVLIAWGIQRGHSVIPKSVTPSRI 263

                         170       180
                  ....*....|....*....|..
gi 1622963998 183 RENVQVFEfqLTSEDMKVLDGL 204
Cdd:cd19118   264 RSNFEQVE--LSDDEFNAVTAL 283
AKR_AKR5B1 cd19127
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ...
 45-205 2.26e-39

AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.


Pssm-ID: 381353 [Multi-domain]  Cd Length: 268  Bit Score: 136.38  E-value: 2.26e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  45 DTVdlcAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPGLKykPVCNQVECHPYLNQSQLLDFCKSEDIVLVAHSAL 124
Cdd:cd19127   112 RTI---QAYKALEKLLAEGRVRAIGVSNFTPEHLERLIDATTVV--PAVNQVELHPYFSQKDLRAFHRRLGIVTQAWSPI 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 125 G-TQRHKLWVDQNSPALLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQLTSEDMKVLDG 203
Cdd:cd19127   187 GgVMRYGASGPTGPGDVLQDPTITGLAEKYGKTPAQIVLRWHLQNGVSAIPKSVHPERIAENIDIFDFALSAEDMAAIDA 266


                  ..
gi 1622963998 204 LN 205
Cdd:cd19127   267 LD 268
AKR_AKR5H1 cd19134
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ...
 53-210 1.64e-38

AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.


Pssm-ID: 381360 [Multi-domain]  Cd Length: 263  Bit Score: 134.21  E-value: 1.64e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  53 WEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPGlkYKPVCNQVECHPYLNQSQLLDFCKSEDIVLVAHSALGTQRhklw 132
Cdd:cd19134   118 WGGLMKLREEGLARSIGVSNFTAEHLENLIDLTF--FTPAVNQIELHPLLNQAELRKVNAQHGIVTQAYSPLGVGR---- 191

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622963998 133 vdqnspaLLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQLTSEDMKVLDGLNGNFRY 210
Cdd:cd19134   192 -------LLDNPAVTAIAAAHGRTPAQVLLRWSLQLGNVVISRSSNPERIASNLDVFDFELTADHMDALDGLDDGTRF 262
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 46-205 1.50e-37

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 132.44  E-value: 1.50e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  46 TVDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPglKYKPVCNQVECHPY--LNQSQLLDFCKSEDIVLVAHSA 123
Cdd:pfam00248 113 DTPIEETWDALEELKKEGKIRAIGVSNFDAEQIEKALTKG--KIPIVAVQVEYNLLrrRQEEELLEYCKKNGIPLIAYSP 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 124 LG----------------TQRHKLWVDQNSPALLEDPVLCALAKKHKPSPALIALRY--QLQRGVVVLAKSYNEQRIREN 185
Cdd:pfam00248 191 LGgglltgkytrdpdkgpGERRRLLKKGTPLNLEALEALEEIAKEHGVSPAQVALRWalSKPGVTIPIPGASNPEQLEDN 270

                         170       180
                  ....*....|....*....|
gi 1622963998 186 VQVFEFQLTSEDMKVLDGLN 205
Cdd:pfam00248 271 LGALEFPLSDEEVARIDELL 290
AKR_AKR2C1 cd19114
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ...
 24-210 7.42e-35

AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.


Pssm-ID: 381340 [Multi-domain]  Cd Length: 302  Bit Score: 125.75  E-value: 7.42e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  24 YVPPEPGETLLPKD-ENGKVIFDTVDLCAIWEAMEKCKDAGLAKSIGVSNFNrrqLEMILNNpgLKY---KPVCNQVECH 99
Cdd:cd19114   109 YVDPAENYPFLWKDkELKKFPLEQSPMQECWREMEKLVDAGLVRNIGIANFN---VQLILDL--LTYakiKPAVLQIEHH 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 100 PYLNQSQLLDFCKSEDIVLVAHSALGTQRHKLWVDQNS--PALLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSY 177
Cdd:cd19114   184 PYLQQKRLIDWAKKQGIQITAYSSFGNAVYTKVTKHLKhfTNLLEHPVVKKLADKHKRDTGQVLLRWAVQRNITVIPKSV 263

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1622963998 178 NEQRIRENVQVFEFQLTSEDMKVLDGLNGNFRY 210
Cdd:cd19114   264 NVERMKTNLDITSYKLDEEDMEALYELEANARF 296
AKR_GlAR-like cd19128
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ...
 29-204 2.92e-34

Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.


Pssm-ID: 381354 [Multi-domain]  Cd Length: 277  Bit Score: 123.40  E-value: 2.92e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  29 PGETLLPKDENGKVIFDTVDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNpgLKYKPVCNQVECHPYLNQSQLL 108
Cdd:cd19128   106 MDTDGDPRDDNQIQSLSKKPLEDTWRAMEQCVDEKLTKNIGVSNYSTKLLTDLLNY--CKIKPFMNQIECHPYFQNDKLI 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 109 DFCKSEDIVLVAHSALGTQRhklwvDQNSPALLEDPVLCALAKKHKPSPALIALRYQLQR---GVVVLAKSYNEQRIREN 185
Cdd:cd19128   184 KFCIENNIHVTAYRPLGGSY-----GDGNLTFLNDSELKALATKYNTTPPQVIIAWHLQKwpkNYSVIPKSANKSRCQQN 258

                         170
                  ....*....|....*....
gi 1622963998 186 VQVFEFQLTSEDMKVLDGL 204
Cdd:cd19128   259 FDINDLALTKEDMDAINTL 277
AKR_AKR5C1 cd19130
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ...
 53-205 4.33e-34

Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.


Pssm-ID: 381356 [Multi-domain]  Cd Length: 256  Bit Score: 122.71  E-value: 4.33e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  53 WEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPGLKykPVCNQVECHPYLNQSQLLDFCKSEDIVLVAHSALGtqrhklw 132
Cdd:cd19130   117 WEAMIELRAAGRTRSIGVSNFLPPHLERIVAATGVV--PAVNQIELHPAYQQRTIRDWAQAHDVKIEAWSPLG------- 187

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622963998 133 vdQNSpaLLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQLTSEDMKVLDGLN 205
Cdd:cd19130   188 --QGK--LLGDPPVGAIAAAHGKTPAQIVLRWHLQKGHVVFPKSVRRERMEDNLDVFDFDLTDTEIAAIDALD 256
AKR_AKR3C1 cd19119
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ...
 28-204 9.39e-34

Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).


Pssm-ID: 381345 [Multi-domain]  Cd Length: 294  Bit Score: 122.61  E-value: 9.39e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  28 EPGETLLPKDENGKVIFD-TVDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNpgLKYKPVCNQVECHPYLNQSQ 106
Cdd:cd19119   121 DSGKPFTPVNDDGKTRYAaSGDHITTYKQLEKIYLDGRAKAIGVSNYSIVYLERLIKE--CKVVPAVNQVELHPHLPQMD 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 107 LLDFCKSEDIVLVAHSALGTQRHklwvdqnspALLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENV 186
Cdd:cd19119   199 LRDFCFKHGILVTAYSPLGSHGA---------PNLKNPLVKKIAEKYNVSTGDILISYHVRQGVIVLPKSLKPVRIVSNG 269

                         170
                  ....*....|....*...
gi 1622963998 187 QVfeFQLTSEDMKVLDGL 204
Cdd:cd19119   270 KI--VSLTKEDLQKLDDI 285
AKR_AKR3F2 cd19139
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ...
 45-204 1.87e-33

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381365 [Multi-domain]  Cd Length: 248  Bit Score: 120.54  E-value: 1.87e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  45 DTVDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPGlKYKPVCNQVECHPYLNQSQLLDFCKSEDIVLVAHSAL 124
Cdd:cd19139   101 DEVPVEEYIGALAEAKEQGLTRHIGVSNFTIALLDEAIAVVG-AGAIATNQIELSPYLQNRKLVAHCKQHGIHVTSYMTL 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 125 GTQRhklwvdqnspaLLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQLTSEDMKVLDGL 204
Cdd:cd19139   180 AYGK-----------VLDDPVLAAIAERHGATPAQIALAWAMARGYAVIPSSTKREHLRSNLLALDLTLDADDMAAIAAL 248
AKR_AKR3F1-like cd19072
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ...
 45-202 3.85e-28

Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381298 [Multi-domain]  Cd Length: 263  Bit Score: 106.93  E-value: 3.85e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  45 DTVDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPGlKYKPVCNQVECHpYLNQ---SQLLDFCKSEDIVLVAH 121
Cdd:cd19072   112 PSIPIEETLRAMEELVEEGKIRYIGVSNFSLEELEEAQSYLK-KGPIVANQVEYN-LFDReeeSGLLPYCQKNGIAIIAY 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 122 SALgtQRHKLWVDQNSPALLEdpvlcaLAKKHKPSPALIALRYQLQR-GVVVLAKSYNEQRIRENVQVFEFQLTSEDMKV 200
Cdd:cd19072   190 SPL--EKGKLSNAKGSPLLDE------IAKKYGKTPAQIALNWLISKpNVIAIPKASNIEHLEENAGALGWELSEEDLQR 261


                  ..
gi 1622963998 201 LD 202
Cdd:cd19072   262 LD 263
dkgA PRK11565
2,5-didehydrogluconate reductase DkgA;
53-198 2.35e-27

2,5-didehydrogluconate reductase DkgA;


Pssm-ID: 183203 [Multi-domain]  Cd Length: 275  Bit Score: 105.15  E-value: 2.35e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  53 WEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPGLKykPVCNQVECHPYLNQSQLLDFCKSEDIVLVAHSALGtqrhklw 132
Cdd:PRK11565  120 WKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVT--PVINQIELHPLMQQRQLHAWNATHKIQTESWSPLA------- 190

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622963998 133 vdQNSPALLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQLTSEDM 198
Cdd:PRK11565  191 --QGGKGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVFDFRLDKDEL 254
AKR_AKR3E1 cd19122
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ...
 53-202 5.73e-27

AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.


Pssm-ID: 381348 [Multi-domain]  Cd Length: 291  Bit Score: 104.63  E-value: 5.73e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  53 WEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPglKYKPVCNQVECHPYLNQSQLLDFCKSEDIVLVAHSALGTQRHklw 132
Cdd:cd19122   145 WRAMEEIYESGKAKAIGVSNWTIPGLKKLLSFA--KVKPHVNQIEIHPFLPNEELVDYCFSNDILPEAYSPLGSQNQ--- 219

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 133 VDQNSPALLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEfqLTSEDMKVLD 202
Cdd:cd19122   220 VPSTGERVSENPTLNEVAEKGGYSLAQVLIAWGLRRGYVVLPKSSTPSRIESNFKSIE--LSDEDFEAIN 287
AKR_AtPLR-like cd19093
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ...
 49-202 1.24e-25

Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.


Pssm-ID: 381319 [Multi-domain]  Cd Length: 293  Bit Score: 101.15  E-value: 1.24e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  49 LCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMI---LNNPGlkYKPVCNQVE---CHPYLNQSQLLDFCKSEDIVLVAHS 122
Cdd:cd19093   120 IEALMDGLADAVEEGLVRAVGVSNYSADQLRRAhkaLKERG--VPLASNQVEyslLYRDPEQNGLLPACDELGITLIAYS 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 123 ALG-----------TQRHKLWVDQNSPALLE--DPVLCAL---AKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENV 186
Cdd:cd19093   198 PLAqglltgkyspeNPPPGGRRRLFGRKNLEkvQPLLDALeeiAEKYGKTPAQVALNWLIAKGVVPIPGAKNAEQAEENA 277

                         170
                  ....*....|....*.
gi 1622963998 187 QVFEFQLTSEDMKVLD 202
Cdd:cd19093   278 GALGWRLSEEEVAELD 293
dkgB PRK11172
2,5-didehydrogluconate reductase DkgB;
45-209 2.02e-22

2,5-didehydrogluconate reductase DkgB;


Pssm-ID: 183012 [Multi-domain]  Cd Length: 267  Bit Score: 92.01  E-value: 2.02e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  45 DTVDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPGlKYKPVCNQVECHPYLNQSQLLDFCKSEDIVLVAHSAL 124
Cdd:PRK11172  103 DEVSVEEFMQALLEAKKQGLTREIGISNFTIALMKQAIAAVG-AENIATNQIELSPYLQNRKVVAFAKEHGIHVTSYMTL 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 125 GTQRhklwvdqnspaLLEDPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQLTSEDMKVLDGL 204
Cdd:PRK11172  182 AYGK-----------VLKDPVIARIAAKHNATPAQVILAWAMQLGYSVIPSSTKRENLASNLLAQDLQLDAEDMAAIAAL 250


                  ....*
gi 1622963998 205 NGNFR 209
Cdd:PRK11172  251 DRNGR 255
AKR_YeaE cd19138
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ...
 54-202 6.51e-21

Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381364 [Multi-domain]  Cd Length: 266  Bit Score: 88.07  E-value: 6.51e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  54 EAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPGLKyKPVCNQVECHpyLNQS----QLLDFCKSEDIVLVAHSAL---GT 126
Cdd:cd19138   122 AAMEELKKEGKIRAWGVSNFDTDDMEELWAVPGGG-NCAANQVLYN--LGSRgieyDLLPWCREHGVPVMAYSPLaqgGL 198

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622963998 127 QRHklwvdqnspALLEDPVLCALAKKHKPSPALIALRYQL-QRGVVVLAKSYNEQRIRENVQVFEFQLTSEDMKVLD 202
Cdd:cd19138   199 LRR---------GLLENPTLKEIAARHGATPAQVALAWVLrDGNVIAIPKSGSPEHARENAAAADLELTEEDLAELD 266
AKR_AKR3F1 cd19137
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ...
 45-202 6.87e-20

Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381363 [Multi-domain]  Cd Length: 260  Bit Score: 85.31  E-value: 6.87e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  45 DTVDLCAI-W-----------EAMEKCKDAGLAKSIGVSNFNRRQLEMILNNpgLKYKPVCNQVECHPY---LNQSQLLD 109
Cdd:cd19137   100 DYIDLYLIhWpnpnipleetlSAMAEGVRQGLIRYIGVSNFNRRLLEEAISK--SQTPIVCNQVKYNLEdrdPERDGLLE 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 110 FCKSEDIVLVAHSALgtqrhklwvdqNSPALLEDPVLCALAKKHKPSPALIALRYQLQR-GVVVLAKSYNEQRIRENVQV 188
Cdd:cd19137   178 YCQKNGITVVAYSPL-----------RRGLEKTNRTLEEIAKNYGKTIAQIALAWLIQKpNVVAIPKAGRVEHLKENLKA 246

                         170
                  ....*....|....
gi 1622963998 189 FEFQLTSEDMKVLD 202
Cdd:cd19137   247 TEIKLSEEEMKLLD 260
PdxI COG0667
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ...
 45-202 4.67e-17

Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440431 [Multi-domain]  Cd Length: 316  Bit Score: 78.30  E-value: 4.67e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  45 DTVDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPGLKYKPVCNQVEchpY--LNQS---QLLDFCKSEDIVLV 119
Cdd:COG0667   127 PDTPIEETLGALDELVREGKIRYIGVSNYSAEQLRRALAIAEGLPPIVAVQNE---YslLDRSaeeELLPAARELGVGVL 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 120 AHSAL-----------------GTQRHKLWVDQNSPALLEDPV--LCALAKKHKPSPALIALRYQLQRGVVVL----AKS 176
Cdd:COG0667   204 AYSPLagglltgkyrrgatfpeGDRAATNFVQGYLTERNLALVdaLRAIAAEHGVTPAQLALAWLLAQPGVTSvipgARS 283

                         170       180
                  ....*....|....*....|....*.
gi 1622963998 177 ynEQRIRENVQVFEFQLTSEDMKVLD 202
Cdd:COG0667   284 --PEQLEENLAAADLELSAEDLAALD 307
AKR_unchar cd19101
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 56-202 3.03e-16

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381327 [Multi-domain]  Cd Length: 304  Bit Score: 75.71  E-value: 3.03e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  56 MEKCKDAGLAKSIGVSNFNRRQLEMILNNPglkYKPVCNQVEcHPYLNQ---SQLLDFCKSEDIVLVAHSALG----TQR 128
Cdd:cd19101   128 LAELQEEGKIRHLGLTNFDTERLREILDAG---VPIVSNQVQ-YSLLDRrpeNGMAALCEDHGIKLLAYGTLAggllSEK 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 129 hklWVDQNSP---------------------------ALLEdpVLCALAKKHKPSPALIALRYQLQR----GVVVLAKsy 177
Cdd:cd19101   204 ---YLGVPEPtgpaletrslqkyklmidewggwdlfqELLR--TLKAIADKHGVSIANVAVRWVLDQpgvaGVIVGAR-- 276

                         170       180
                  ....*....|....*....|....*
gi 1622963998 178 NEQRIRENVQVFEFQLTSEDMKVLD 202
Cdd:cd19101   277 NSEHIDDNVRAFSFRLDDEDRAAID 301
AKR_AKR11B1-like cd19084
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ...
 46-202 1.98e-15

AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.


Pssm-ID: 381310 [Multi-domain]  Cd Length: 296  Bit Score: 73.33  E-value: 1.98e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  46 TVDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMIlnnpgLKY-KPVCNQVechPY--LNQ---SQLLDFCKSEDIVLV 119
Cdd:cd19084   120 NTPIEETAEALEKLKKEGKIRYIGVSNFSVEQLEEA-----RKYgPIVSLQP---PYsmLEReieEELLPYCRENGIGVL 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 120 AHSALGT-------------------QRHKLWVDQNSPALLE--DpVLCALAKKHKPSPALIALRYQLQR-GV-VVLAKS 176
Cdd:cd19084   192 PYGPLAQglltgkykkeptfppddrrSRFPFFRGENFEKNLEivD-KLKEIAEKYGKSLAQLAIAWTLAQpGVtSAIVGA 270

                         170       180
                  ....*....|....*....|....*.
gi 1622963998 177 YNEQRIRENVQVFEFQLTSEDMKVLD 202
Cdd:cd19084   271 KNPEQLEENAGALDWELTEEELKEID 296
YdhF COG4989
Predicted oxidoreductase YdhF [General function prediction only];
54-197 1.01e-14

Predicted oxidoreductase YdhF [General function prediction only];


Pssm-ID: 444013 [Multi-domain]  Cd Length: 299  Bit Score: 71.34  E-value: 1.01e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  54 EAMEKCKDAGLAKSIGVSNFNRRQLEMIlnNPGLKYKPVCNQVECHPYLNQ---SQLLDFCKSEDIVLVAHSALGTQRHK 130
Cdd:COG4989   141 EAFDELKASGKVRHFGVSNFTPSQFELL--QSALDQPLVTNQIELSLLHTDafdDGTLDYCQLNGITPMAWSPLAGGRLF 218

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 131 LWVDQNSPALLEdpVLCALAKKHKPSPALIALRYqLQR---GVVVLAKSYNEQRIRENVQVFEFQLTSED 197
Cdd:COG4989   219 GGFDEQFPRLRA--ALDELAEKYGVSPEAIALAW-LLRhpaGIQPVIGTTNPERIKAAAAALDIELTREE 285
AKR_BsYcsN_EcYdhF-like cd19092
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ...
 54-197 4.84e-13

Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.


Pssm-ID: 381318 [Multi-domain]  Cd Length: 287  Bit Score: 66.43  E-value: 4.84e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  54 EAMEKCKDAGLAKSIGVSNFNRRQLEMIlnNPGLKYKPVCNQVEC---HPYLNQSQLLDFCKSEDIVLVAHSALGTQRHK 130
Cdd:cd19092   134 EAFDELVKSGKVRYFGVSNFTPSQIELL--QSYLDQPLVTNQIELsllHTEAIDDGTLDYCQLLDITPMAWSPLGGGRLF 211

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 131 LWVDQNSPALLEdpVLCALAKKHKPSPALIALRYQLQ---RGVVVLAkSYNEQRIRENVQVFEFQLTSED 197
Cdd:cd19092   212 GGFDERFQRLRA--ALEELAEEYGVTIEAIALAWLLRhpaRIQPILG-TTNPERIRSAVKALDIELTREE 278
AKR_AKR11B3 cd19085
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ...
 46-208 2.38e-12

Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.


Pssm-ID: 381311 [Multi-domain]  Cd Length: 292  Bit Score: 64.53  E-value: 2.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  46 TVDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILnNPGlkyKPVCNQVechPY--LNQS---QLLDFCKSEDIVLVA 120
Cdd:cd19085   109 DVPLEETMEALEKLKEEGKIRAIGVSNFGPAQLEEAL-DAG---RIDSNQL---PYnlLWRAieyEILPFCREHGIGVLA 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 121 HSAL-----------------GTQRHKLWV---DQNSPALLED-PVLCALAKKHKPSPALIALRYQLQRGVV--VLAKSY 177
Cdd:cd19085   182 YSPLaqglltgkfssaedfppGDARTRLFRhfePGAEEETFEAlEKLKEIADELGVTMAQLALAWVLQQPGVtsVIVGAR 261

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1622963998 178 NEQRIRENVQVFEFQLTSEDMKVLDGLNGNF 208
Cdd:cd19085   262 NPEQLEENAAAVDLELSPSVLERLDEISDPL 292
AKR_AKR13B1 cd19088
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ...
 43-194 9.03e-11

AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.


Pssm-ID: 381314 [Multi-domain]  Cd Length: 256  Bit Score: 59.92  E-value: 9.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  43 IFDTVDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPGLkykpVCNQVECHPYLNQS-QLLDFCKSEDIVLVAH 121
Cdd:cd19088   116 IDPKVPFEEQLGALAELQDEGLIRHIGLSNVTVAQIEEARAIVRI----VSVQNRYNLANRDDeGVLDYCEAAGIAFIPW 191

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622963998 122 SALGTQRhklwVDQNSPALLEdpvlcaLAKKHKPSPALIALRYQLQRG--VVVLAKSYNEQRIRENVQVFEFQLT 194
Cdd:cd19088   192 FPLGGGD----LAQPGGLLAE------VAARLGATPAQVALAWLLARSpvMLPIPGTSSVEHLEENLAAAGLRLS 256
AKR_unchar cd19102
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 46-204 1.68e-09

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381328 [Multi-domain]  Cd Length: 302  Bit Score: 56.53  E-value: 1.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  46 TVDLCAIWEAMEKCKDAGLAKSIGVSNFNRRQLEMI--------LNNPglkYKPVCNQVEchpylnqSQLLDFCKSEDIV 117
Cdd:cd19102   121 DEPIEEAWGALAELKEEGKVRAIGVSNFSVDQMKRCqaihpiasLQPP---YSLLRRGIE-------AEILPFCAEHGIG 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 118 LVAHSALGT---------QR-HKLWVD---QNSPALLED---------PVLCALAKKHKPSPALIALRYQLQRGVV--VL 173
Cdd:cd19102   191 VIVYSPMQSglltgkmtpERvASLPADdwrRRSPFFQEPnlarnlalvDALRPIAERHGRTVAQLAIAWVLRRPEVtsAI 270

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1622963998 174 AKSYNEQRIRENVQVFEFQLTSEDMKVLDGL 204
Cdd:cd19102   271 VGARRPDQIDETVGAADLRLTPEELAEIEAL 301
AKR_SF cd06660
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
 45-187 1.94e-08

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


Pssm-ID: 381296 [Multi-domain]  Cd Length: 232  Bit Score: 52.91  E-value: 1.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  45 DTVDLC------------AIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILN--NPGLKYKPVCNQVE---CHPYLNQSQL 107
Cdd:cd06660   100 DYIDLYylhrddpstpveETLEALNELVREGKIRYIGVSNWSAERLAEALAyaKAHGLPGFAAVQPQyslLDRSPMEEEL 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 108 LDFCKSEDIVLVAHSALGTqrhklwvdqnspalledpvlcalakkhkpSPALIALRYQLQR--GVVVLAKSYNEQRIREN 185
Cdd:cd06660   180 LDWAEENGLPLLAYSPLAR-----------------------------GPAQLALAWLLSQpfVTVPIVGARSPEQLEEN 230


                  ..
gi 1622963998 186 VQ 187
Cdd:cd06660   231 LA 232
AKR_AKR9C1 cd19081
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ...
 54-202 1.02e-06

AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).


Pssm-ID: 381307 [Multi-domain]  Cd Length: 308  Bit Score: 48.36  E-value: 1.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  54 EAMEKCKDAGLAKSIGVSNFNRRQLEMILN---NPGLKyKPVCNQ-----VECHPYlnQSQLLDFCKSEDIVLVAHSALG 125
Cdd:cd19081   135 GALNDLIRQGKVRYIGASNYSAWRLQEALElsrQHGLP-RYVSLQpeynlVDRESF--EGELLPLCREEGIGVIPYSPLA 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 126 -----------------TQRHKLWVDQNSP---ALLEdpVLCALAKKHKPSPALIALRYQLQRGVV--VLAKSYNEQRIR 183
Cdd:cd19081   212 ggfltgkyrseadlpgsTRRGEAAKRYLNErglRILD--ALDEVAAEHGATPAQVALAWLLARPGVtaPIAGARTVEQLE 289

                         170
                  ....*....|....*....
gi 1622963998 184 ENVQVFEFQLTSEDMKVLD 202
Cdd:cd19081   290 DLLAAAGLRLTDEEVARLD 308
AKR_AKR11B2 cd19149
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ...
 53-202 2.58e-06

Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.


Pssm-ID: 381375 [Multi-domain]  Cd Length: 315  Bit Score: 47.27  E-value: 2.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  53 WEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPGL-----KYKPVCNQVEchpylnqSQLLDFCKSEDIVLVAHSAL--- 124
Cdd:cd19149   145 MEALEELKRQGKIRAIGASNVSVEQIKEYVKAGQLdiiqeKYSMLDRGIE-------KELLPYCKKNNIAFQAYSPLeqg 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 125 --------------GTQR--HKLWVDQNSP---ALLED--PvlcaLAKKHKPSPALIALRYQLQRG--VVVLAKSYNEQR 181
Cdd:cd19149   218 lltgkitpdrefdaGDARsgIPWFSPENREkvlALLEKwkP----LCEKYGCTLAQLVIAWTLAQPgiTSALCGARKPEQ 293

                         170       180
                  ....*....|....*....|.
gi 1622963998 182 IRENVQVFEFQLTSEDMKVLD 202
Cdd:cd19149   294 AEENAKAGDIRLSAEDIATMR 314
AKR_AKR8A1-2 cd19077
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ...
 54-202 6.40e-06

AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).


Pssm-ID: 381303 [Multi-domain]  Cd Length: 302  Bit Score: 46.08  E-value: 6.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  54 EAMEKCKDAGLAKSIGVSNFNRRQLEMILnnpglKYKPV-CNQVECHPYLN---QSQLLDFCKSEDIVLVAHSALG---- 125
Cdd:cd19077   132 KALKELVKEGKIRGIGLSEVSAETIRRAH-----AVHPIaAVEVEYSLFSReieENGVLETCAELGIPIIAYSPLGrgll 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 126 TQRHKLWVD-------QNSP-----------ALLEdpVLCALAKKHKPSPALIAL---RYQLQRGVVVLAKSYNEQRIRE 184
Cdd:cd19077   207 TGRIKSLADipegdfrRHLDrfngenfeknlKLVD--ALQELAEKKGCTPAQLALawiLAQSGPKIIPIPGSTTLERVEE 284

                         170
                  ....*....|....*...
gi 1622963998 185 NVQVFEFQLTSEDMKVLD 202
Cdd:cd19077   285 NLKAANVELTDEELKEIN 302
AKR_PsAKR cd19091
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ...
 54-202 8.23e-06

Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.


Pssm-ID: 381317 [Multi-domain]  Cd Length: 319  Bit Score: 45.68  E-value: 8.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  54 EAMEKCKDAGLAKSIGVSNFNRRQLEMIL---NNPGLKyKPVCNQVechpYLN------QSQLLDFCKSEDIVLVAHSAL 124
Cdd:cd19091   141 RALDDLVRQGKVRYIGVSNFSAWQIMKALgisERRGLA-RFVALQA----YYSllgrdlEHELMPLALDQGVGLLVWSPL 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 125 GTQR--HKLWVDQNSPAL------------LEDP-------VLCALAKKHKPSPALIALRYQLQR----GVVVLAKsyNE 179
Cdd:cd19091   216 AGGLlsGKYRRGQPAPEGsrlrrtgfdfppVDRErgydvvdALREIAKETGATPAQVALAWLLSRptvsSVIIGAR--NE 293

                         170       180
                  ....*....|....*....|...
gi 1622963998 180 QRIRENVQVFEFQLTSEDMKVLD 202
Cdd:cd19091   294 EQLEDNLGAAGLSLTPEEIARLD 316
AKR_unchar cd19103
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 63-204 3.26e-05

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381329 [Multi-domain]  Cd Length: 299  Bit Score: 43.86  E-value: 3.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  63 GLAKSIGVSNFNRRQLEM---ILNNPGLKYKPVCNqvecHPYL-----NQSQLLDFCKSEDIVLVAHSAL---------- 124
Cdd:cd19103   135 GKVKHVGVSNHNLAEIKRaneILAKAGVSLSAVQN----HYSLlyrssEEAGILDYCKENGITFFAYMVLeqgalsgkyd 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 125 -------GTQRHKLWvdqNS--PALLE-DPVLCALAKKHKPSPALIALRYQLQRGVVVLAKSYNEQRIRENVQVFEFQLT 194
Cdd:cd19103   211 tkhplpeGSGRAETY---NPllPQLEElTAVMAEIGAKHGASIAQVAIAWAIAKGTTPIIGVTKPHHVEDAARAASITLT 287

                         170
                  ....*....|
gi 1622963998 195 SEDMKVLDGL 204
Cdd:cd19103   288 DDEIKELEQL 297
AKR_AKR11B1 cd19148
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ...
 54-202 9.75e-05

Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381374 [Multi-domain]  Cd Length: 302  Bit Score: 42.29  E-value: 9.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  54 EAMEKCKDAGLAKSIGVSNFNRRQLEmilnnpglKYKPVCNQVECHPYLN------QSQLLDFCKSEDIVLVAHSAL--G 125
Cdd:cd19148   130 EALKELLDEGKIRAIGVSNFSPEQME--------TFRKVAPLHTVQPPYNlfereiEKDVLPYARKHNIVTLAYGALcrG 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 126 TQRHKLWVD---------QNSPALLEDPV---------LCALAKKH--KPSPALiALRYQLQRG--VVVLAKSYNEQRIR 183
Cdd:cd19148   202 LLSGKMTKDtkfegddlrRTDPKFQEPRFsqylaaveeLDKLAQERygKSVIHL-AVRWLLDQPgvSIALWGARKPEQLD 280

                         170
                  ....*....|....*....
gi 1622963998 184 ENVQVFEFQLTSEDMKVLD 202
Cdd:cd19148   281 AVDEVFGWSLNDEDMKEID 299
AKR_galDH cd19163
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ...
 55-196 1.07e-04

L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).


Pssm-ID: 381389 [Multi-domain]  Cd Length: 293  Bit Score: 42.15  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  55 AMEKCKDAGLAKSIGVSNFNRRQLEMIL-NNPG-----LKYkpvcnqveCHPYLNQSQLLD---FCKSEDIVLVAHSALG 125
Cdd:cd19163   141 ALQKLKEEGKVRFIGITGYPLDVLKEVLeRSPVkidtvLSY--------CHYTLNDTSLLEllpFFKEKGVGVINASPLS 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998 126 ----TQR-----HklwvdqnsPALLEDPVLCALAKKH---KPSP-ALIALRYQLQ--RGVVVLAKSYNEQRIRENVQVFE 190
Cdd:cd19163   213 mgllTERgppdwH--------PASPEIKEACAKAAAYcksRGVDiSKLALQFALSnpDIATTLVGTASPENLRKNLEAAE 284


                  ....*.
gi 1622963998 191 FQLTSE 196
Cdd:cd19163   285 EPLDAH 290
AKR_unchar cd19097
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 51-190 1.99e-04

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381323 [Multi-domain]  Cd Length: 267  Bit Score: 41.36  E-value: 1.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963998  51 AIWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNNPGLKYkpVcnQVechPY------LNQSQLLDFCKSEDIVLVAHSAL 124
Cdd:cd19097   119 KLVEALLELKKEGLIRKIGVSVYSPEELEKALESFKIDI--I--QL---PFnildqrFLKSGLLAKLKKKGIEIHARSVF 191

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622963998 125 --G--TQRHKLWVDQNSPA--LLEDpvLCALAKKHKPSPALIALRYQLQR----GVVVLAKSYNEqrIRENVQVFE 190
Cdd:cd19097   192 lqGllLMEPDKLPAKFAPAkpLLKK--LHELAKKLGLSPLELALGFVLSLpeidKIVVGVDSLEQ--LKEIIAAFK 263
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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