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Conserved domains on  [gi|966960707|ref|XP_015001813|]
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WD repeat-containing protein 37 isoform X1 [Macaca mulatta]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
147-487 1.86e-45

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 163.93  E-value: 1.86e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 147 QLVKEYIGHRDGIWDVSVARTqPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:COG2319   69 ALLATLLGHTAAVLSVAFSPD-GRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 227 RyavqLPTPQPVADTSQISGE-DEVECSDkdepdlDGD---VSSDCPTIRV-------PLTSLKSHQGVVIAADWLVGGK 295
Cdd:COG2319  148 D----LATGKLLRTLTGHSGAvTSVAFSP------DGKllaSGSDDGTVRLwdlatgkLLRTLTGHTGAVRSVAFSPDGK 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 296 QAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIhsVNVFQGHTDTVTSAV 375
Cdd:COG2319  218 LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL--LRTLTGHSGGVNSVA 295

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 376 FT-VGDNVVSGSDDRTVKVWDLKNmRSPIATIR-TDSAINRINVCVGQKIIALPHDNRQVRLFDMSGVRLARlprsSRQG 453
Cdd:COG2319  296 FSpDGKLLASGSDDGTVRLWDLAT-GKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLR----TLTG 370

                        330       340       350
                 ....*....|....*....|....*....|....
gi 966960707 454 HRRMVCCSAWSEDHPVcnLFTCGFDRQAIGWNIN 487
Cdd:COG2319  371 HTGAVTSVAFSPDGRT--LASGSADGTVRLWDLA 402
DivIVA super family cl34642
Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle ...
 64-91 1.74e-03

Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG3599:

Pssm-ID: 442818 [Multi-domain]  Cd Length: 125  Bit Score: 38.30  E-value: 1.74e-03
                         10        20
                 ....*....|....*....|....*...
gi 966960707  64 QIEREFENLYIENLELRREIDTLNERLA 91
Cdd:COG3599   31 EVAEDYERLIRENKELKEKLEELEEELE 58
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
147-487 1.86e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 163.93  E-value: 1.86e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 147 QLVKEYIGHRDGIWDVSVARTqPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:COG2319   69 ALLATLLGHTAAVLSVAFSPD-GRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 227 RyavqLPTPQPVADTSQISGE-DEVECSDkdepdlDGD---VSSDCPTIRV-------PLTSLKSHQGVVIAADWLVGGK 295
Cdd:COG2319  148 D----LATGKLLRTLTGHSGAvTSVAFSP------DGKllaSGSDDGTVRLwdlatgkLLRTLTGHTGAVRSVAFSPDGK 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 296 QAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIhsVNVFQGHTDTVTSAV 375
Cdd:COG2319  218 LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL--LRTLTGHSGGVNSVA 295

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 376 FT-VGDNVVSGSDDRTVKVWDLKNmRSPIATIR-TDSAINRINVCVGQKIIALPHDNRQVRLFDMSGVRLARlprsSRQG 453
Cdd:COG2319  296 FSpDGKLLASGSDDGTVRLWDLAT-GKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLR----TLTG 370

                        330       340       350
                 ....*....|....*....|....*....|....
gi 966960707 454 HRRMVCCSAWSEDHPVcnLFTCGFDRQAIGWNIN 487
Cdd:COG2319  371 HTGAVTSVAFSPDGRT--LASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 148-485 7.09e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 159.04  E-value: 7.09e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 148 LVKEYIGHRDGIWDVSVARTQPVVLgTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWr 227
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLA-TGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 228 yavqlptpqpvadtsqisgedevecsdkdepdldgDVSSDCptirvPLTSLKSHQGVVIAADWLVGGKQAVTASWDRTAN 307
Cdd:cd00200   79 -----------------------------------DLETGE-----CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIK 118

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 308 LYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRdpSIHSVNVFQGHTDTVTSAVFT-VGDNVVSGS 386
Cdd:cd00200  119 VWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR--TGKCVATLTGHTGEVNSVAFSpDGEKLLSSS 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 387 DDRTVKVWDLKnMRSPIATIRT-DSAINRINVCVGQKIIALPHDNRQVRLFDM-SGVRLARLprssrQGHRRMVCCSAWS 464
Cdd:cd00200  197 SDGTIKLWDLS-TGKCLGTLRGhENGVNSVAFSPDGYLLASGSEDGTIRVWDLrTGECVQTL-----SGHTNSVTSLAWS 270

                        330       340
                 ....*....|....*....|.
gi 966960707 465 EDHPVcnLFTCGFDRQAIGWN 485
Cdd:cd00200  271 PDGKR--LASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 188-226 1.63e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.63e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 966960707   188 TGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
189-226 4.55e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 4.55e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 966960707  189 GKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00421 PTZ00421
coronin; Provisional
 153-409 2.88e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.42  E-value: 2.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 153 IGHRDGIWDVSVARTQPVVLGTASADHTALLWSI-------ETGKCLVKYAGHVGSVNSIKFHPSEQLALTASG-DQTAH 224
Cdd:PTZ00421  72 LGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGaDMVVN 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 225 IWryavqlptpqpvadtsqisgedevecsdkdepdldgDVSSDcptirVPLTSLKSHQGVVIAADWLVGGKQAVTASWDR 304
Cdd:PTZ00421 152 VW------------------------------------DVERG-----KAVEVIKCHSDQITSLEWNLDGSLLCTTSKDK 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 305 TANLYDVETSELVHSLTGHDqelthccTHPTQRLVVTSSRDTtfrlwdfrdpsihsvnvfqghtdtvtsaVFTVGdnvVS 384
Cdd:PTZ00421 191 KLNIIDPRDGTIVSSVEAHA-------SAKSQRCLWAKRKDL----------------------------IITLG---CS 232

                        250       260
                 ....*....|....*....|....*
gi 966960707 385 GSDDRTVKVWDLKNMRSPIATIRTD 409
Cdd:PTZ00421 233 KSQQRQIMLWDTRKMASPYSTVDLD 257
DivIVA COG3599
Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle ...
 64-91 1.74e-03

Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442818 [Multi-domain]  Cd Length: 125  Bit Score: 38.30  E-value: 1.74e-03
                         10        20
                 ....*....|....*....|....*...
gi 966960707  64 QIEREFENLYIENLELRREIDTLNERLA 91
Cdd:COG3599   31 EVAEDYERLIRENKELKEKLEELEEELE 58
DivIVA pfam05103
DivIVA protein; The Bacillus subtilis divIVA1 mutation causes misplacement of the septum ...
 60-91 7.07e-03

DivIVA protein; The Bacillus subtilis divIVA1 mutation causes misplacement of the septum during cell division, resulting in the formation of small, circular, anucleate mini-cells. Inactivation of divIVA produces a mini-cell phenotype, whereas overproduction of DivIVA results in a filamentation phenotype. These proteins appear to contain coiled-coils.


Pssm-ID: 428304 [Multi-domain]  Cd Length: 131  Bit Score: 36.78  E-value: 7.07e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 966960707   60 ELFGQIEREFENLYIENLELRREIDTLNERLA 91
Cdd:pfam05103  25 EFLDQVAEDYEALIRENAELKEKIEELEEKLA 56
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
147-487 1.86e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 163.93  E-value: 1.86e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 147 QLVKEYIGHRDGIWDVSVARTqPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:COG2319   69 ALLATLLGHTAAVLSVAFSPD-GRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 227 RyavqLPTPQPVADTSQISGE-DEVECSDkdepdlDGD---VSSDCPTIRV-------PLTSLKSHQGVVIAADWLVGGK 295
Cdd:COG2319  148 D----LATGKLLRTLTGHSGAvTSVAFSP------DGKllaSGSDDGTVRLwdlatgkLLRTLTGHTGAVRSVAFSPDGK 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 296 QAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIhsVNVFQGHTDTVTSAV 375
Cdd:COG2319  218 LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL--LRTLTGHSGGVNSVA 295

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 376 FT-VGDNVVSGSDDRTVKVWDLKNmRSPIATIR-TDSAINRINVCVGQKIIALPHDNRQVRLFDMSGVRLARlprsSRQG 453
Cdd:COG2319  296 FSpDGKLLASGSDDGTVRLWDLAT-GKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLR----TLTG 370

                        330       340       350
                 ....*....|....*....|....*....|....
gi 966960707 454 HRRMVCCSAWSEDHPVcnLFTCGFDRQAIGWNIN 487
Cdd:COG2319  371 HTGAVTSVAFSPDGRT--LASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 148-485 7.09e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 159.04  E-value: 7.09e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 148 LVKEYIGHRDGIWDVSVARTQPVVLgTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWr 227
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLA-TGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 228 yavqlptpqpvadtsqisgedevecsdkdepdldgDVSSDCptirvPLTSLKSHQGVVIAADWLVGGKQAVTASWDRTAN 307
Cdd:cd00200   79 -----------------------------------DLETGE-----CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIK 118

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 308 LYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRdpSIHSVNVFQGHTDTVTSAVFT-VGDNVVSGS 386
Cdd:cd00200  119 VWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR--TGKCVATLTGHTGEVNSVAFSpDGEKLLSSS 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 387 DDRTVKVWDLKnMRSPIATIRT-DSAINRINVCVGQKIIALPHDNRQVRLFDM-SGVRLARLprssrQGHRRMVCCSAWS 464
Cdd:cd00200  197 SDGTIKLWDLS-TGKCLGTLRGhENGVNSVAFSPDGYLLASGSEDGTIRVWDLrTGECVQTL-----SGHTNSVTSLAWS 270

                        330       340
                 ....*....|....*....|.
gi 966960707 465 EDHPVcnLFTCGFDRQAIGWN 485
Cdd:cd00200  271 PDGKR--LASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
147-440 2.99e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 160.46  E-value: 2.99e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 147 QLVKEYIGHRDGIWDVSVARTQPVVLgTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLA-SGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 227 RYAVQLPTPQPVADTSQISGedeVECSDkdepdlDGD---VSSDCPTIRV-------PLTSLKSHQGVVIAADWLVGGKQ 296
Cdd:COG2319  190 DLATGKLLRTLTGHTGAVRS---VAFSP------DGKllaSGSADGTVRLwdlatgkLLRTLTGHSGSVRSVAFSPDGRL 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 297 AVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIhsVNVFQGHTDTVTSAVF 376
Cdd:COG2319  261 LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL--LRTLTGHTGAVRSVAF 338

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966960707 377 T-VGDNVVSGSDDRTVKVWDLKNMRSPIATIRTDSAINRINVCVGQKIIALPHDNRQVRLFDMSG 440
Cdd:COG2319  339 SpDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 128-437 3.54e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 157.11  E-value: 3.54e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 128 ASTSKIVSSFKTTTsraaCQLVKEYIGHRDGIWDVS-VARTQPVVlgTASADHTALLWSIETGKCLVKYAGHVGSVNSIK 206
Cdd:cd00200   27 GSGDGTIKVWDLET----GELLRTLKGHTGPVRDVAaSADGTYLA--SGSSDKTIRLWDLETGECVRTLTGHTSYVSSVA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 207 FHPSEQLALTASGDQTAHIWryavQLPTPQPVadtsqisgedevecsdkdepdldgdvssdcptirvplTSLKSHQGVVI 286
Cdd:cd00200  101 FSPDGRILSSSSRDKTIKVW----DVETGKCL-------------------------------------TTLRGHTDWVN 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 287 AADWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRdpSIHSVNVFQG 366
Cdd:cd00200  140 SVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS--TGKCLGTLRG 217

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966960707 367 HTDTVTSAVFTVGDN-VVSGSDDRTVKVWDLKNmRSPIATIR-TDSAINRINVC-VGQKIIALPHDNRqVRLFD 437
Cdd:cd00200  218 HENGVNSVAFSPDGYlLASGSEDGTIRVWDLRT-GECVQTLSgHTNSVTSLAWSpDGKRLASGSADGT-IRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 197-494 2.91e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 141.32  E-value: 2.91e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 197 GHVGSVNSIKFHPSEQLALTASGDQTAHIWryavqlptpqpvadtsqisgedevecsdkdepDLDGDVssdcptirvPLT 276
Cdd:cd00200    7 GHTGGVTCVAFSPDGKLLATGSGDGTIKVW--------------------------------DLETGE---------LLR 45

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 277 SLKSHQGVVIAADWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDP 356
Cdd:cd00200   46 TLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 357 SIhsVNVFQGHTDTVTSAVFTVGDN-VVSGSDDRTVKVWDLKNMRsPIATIRT-DSAINRINVCVGQKIIALPHDNRQVR 434
Cdd:cd00200  126 KC--LTTLRGHTDWVNSVAFSPDGTfVASSSQDGTIKLWDLRTGK-CVATLTGhTGEVNSVAFSPDGEKLLSSSSDGTIK 202

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 435 LFDMSGVRLARLPRssrqGHRRMVCCSAWSEDHPVcnLFTCGFDRQAIGWNINIPALLQE 494
Cdd:cd00200  203 LWDLSTGKCLGTLR----GHENGVNSVAFSPDGYL--LASGSEDGTIRVWDLRTGECVQT 256
WD40 COG2319
WD40 repeat [General function prediction only];
162-494 9.83e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 142.74  E-value: 9.83e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 162 VSVARTQPVVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIWRYAVQLPTPQPVADT 241
Cdd:COG2319   41 SLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHT 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 242 SQISGedeVECSDkdepdlDGD----VSSDcPTIRV-------PLTSLKSHQGVVIAADWLVGGKQAVTASWDRTANLYD 310
Cdd:COG2319  121 GAVRS---VAFSP------DGKtlasGSAD-GTVRLwdlatgkLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 311 VETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIhsVNVFQGHTDTVTSAVFTV-GDNVVSGSDDR 389
Cdd:COG2319  191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL--LRTLTGHSGSVRSVAFSPdGRLLASGSADG 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 390 TVKVWDLKNmRSPIATIRTDS-AINRINVCVGQKIIALPHDNRQVRLFDMSGVRLARlprsSRQGHRRMVCCSAWSEDHP 468
Cdd:COG2319  269 TVRLWDLAT-GELLRTLTGHSgGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR----TLTGHTGAVRSVAFSPDGK 343

                        330       340
                 ....*....|....*....|....*.
gi 966960707 469 VcnLFTCGFDRQAIGWNINIPALLQE 494
Cdd:COG2319  344 T--LASGSDDGTVRLWDLATGELLRT 367
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 278-493 1.18e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 114.74  E-value: 1.18e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 278 LKSHQGVVIAADWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPs 357
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG- 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 358 iHSVNVFQGHTDTVTSAVFTVGDN-VVSGSDDRTVKVWDLKNmRSPIATIRT-DSAINRINVCVGQKIIALPHDNRQVRL 435
Cdd:cd00200   84 -ECVRTLTGHTSYVSSVAFSPDGRiLSSSSRDKTIKVWDVET-GKCLTTLRGhTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966960707 436 FDM-SGVRLARLPrssrqGHRRMVCCSAWSEDHPvcNLFTCGFDRQAIGWNINIPALLQ 493
Cdd:cd00200  162 WDLrTGKCVATLT-----GHTGEVNSVAFSPDGE--KLLSSSSDGTIKLWDLSTGKCLG 213
WD40 COG2319
WD40 repeat [General function prediction only];
259-487 7.71e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.51  E-value: 7.71e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 259 DLDGDVSSDCPTIRVPLTSLKSHQGVVIAADWLVGGKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRL 338
Cdd:COG2319   13 SADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 339 VVTSSRDTTFRLWDFRDPsiHSVNVFQGHTDTVTSAVFT-VGDNVVSGSDDRTVKVWDLKNmRSPIATIRTDS-AINRIN 416
Cdd:COG2319   93 LASASADGTVRLWDLATG--LLLRTLTGHTGAVRSVAFSpDGKTLASGSADGTVRLWDLAT-GKLLRTLTGHSgAVTSVA 169

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966960707 417 VCVGQKIIALPHDNRQVRLFDM-SGVRLARLprssrQGHRRMVCCSAWSEDHPVcnLFTCGFDRQAIGWNIN 487
Cdd:COG2319  170 FSPDGKLLASGSDDGTVRLWDLaTGKLLRTL-----TGHTGAVRSVAFSPDGKL--LASGSADGTVRLWDLA 234
WD40 COG2319
WD40 repeat [General function prediction only];
294-494 5.56e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.08  E-value: 5.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 294 GKQAVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWDFRDPSIhsVNVFQGHTDTVTS 373
Cdd:COG2319    6 GAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGAL--LATLLGHTAAVLS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 374 AVFTV-GDNVVSGSDDRTVKVWDLKNMRSPIATIRTDSAINRINVCVGQKIIALPHDNRQVRLFDM-SGVRLARLPrssr 451
Cdd:COG2319   84 VAFSPdGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLaTGKLLRTLT---- 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 966960707 452 qGHRRMVCCSAWSEDHPVcnLFTCGFDRQAIGWNINIPALLQE 494
Cdd:COG2319  160 -GHSGAVTSVAFSPDGKL--LASGSDDGTVRLWDLATGKLLRT 199
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 188-226 1.63e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.63e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 966960707   188 TGKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
189-226 4.55e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 4.55e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 966960707  189 GKCLVKYAGHVGSVNSIKFHPSEQLALTASGDQTAHIW 226
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 313-352 5.24e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 5.24e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 966960707   313 TSELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWD 352
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
361-395 7.00e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 7.00e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 966960707  361 VNVFQGHTDTVTSAVFTV-GDNVVSGSDDRTVKVWD 395
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPdGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
314-352 1.11e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.11e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 966960707  314 SELVHSLTGHDQELTHCCTHPTQRLVVTSSRDTTFRLWD 352
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 357-395 1.62e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.62e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 966960707   357 SIHSVNVFQGHTDTVTSAVFT-VGDNVVSGSDDRTVKVWD 395
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSpDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 153-409 2.88e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.42  E-value: 2.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 153 IGHRDGIWDVSVARTQPVVLGTASADHTALLWSI-------ETGKCLVKYAGHVGSVNSIKFHPSEQLALTASG-DQTAH 224
Cdd:PTZ00421  72 LGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGaDMVVN 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 225 IWryavqlptpqpvadtsqisgedevecsdkdepdldgDVSSDcptirVPLTSLKSHQGVVIAADWLVGGKQAVTASWDR 304
Cdd:PTZ00421 152 VW------------------------------------DVERG-----KAVEVIKCHSDQITSLEWNLDGSLLCTTSKDK 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 305 TANLYDVETSELVHSLTGHDqelthccTHPTQRLVVTSSRDTtfrlwdfrdpsihsvnvfqghtdtvtsaVFTVGdnvVS 384
Cdd:PTZ00421 191 KLNIIDPRDGTIVSSVEAHA-------SAKSQRCLWAKRKDL----------------------------IITLG---CS 232

                        250       260
                 ....*....|....*....|....*
gi 966960707 385 GSDDRTVKVWDLKNMRSPIATIRTD 409
Cdd:PTZ00421 233 KSQQRQIMLWDTRKMASPYSTVDLD 257
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 330-417 1.20e-03

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 41.61  E-value: 1.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 330 CCTH---PTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFqGHTDTVTSAVFTVGDNVVSGSDDRTVKVWDLKNMRSPIATI 406
Cdd:PLN00181 621 CCVQfpsESGRSLAFGSADHKVYYYDLRNPKLPLCTMI-GHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISGINET 699

                         90
                 ....*....|.
gi 966960707 407 RTDSAINRINV 417
Cdd:PLN00181 700 PLHSFMGHTNV 710
DivIVA COG3599
Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle ...
 64-91 1.74e-03

Cell division septum initiation protein DivIVA, interacts with FtsZ and MinD [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442818 [Multi-domain]  Cd Length: 125  Bit Score: 38.30  E-value: 1.74e-03
                         10        20
                 ....*....|....*....|....*...
gi 966960707  64 QIEREFENLYIENLELRREIDTLNERLA 91
Cdd:COG3599   31 EVAEDYERLIRENKELKEKLEELEEELE 58
WD40 COG2319
WD40 repeat [General function prediction only];
334-494 3.12e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.89  E-value: 3.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 334 PTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFqGHTDTVTSAVFTVGDNVVSGSDDRTVKVWDLKNMRSPIATIRTDSAIN 413
Cdd:COG2319    4 ADGAALAAASADLALALLAAALGALLLLLLG-LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960707 414 RINVCVGQKIIALPHDNRQVRLFDMSGVRLARLPrssrQGHRRMVCCSAWSEDHPVcnLFTCGFDRQAIGWNINIPALLQ 493
Cdd:COG2319   83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTL----TGHTGAVRSVAFSPDGKT--LASGSADGTVRLWDLATGKLLR 156


                 .
gi 966960707 494 E 494
Cdd:COG2319  157 T 157
DivIVA pfam05103
DivIVA protein; The Bacillus subtilis divIVA1 mutation causes misplacement of the septum ...
 60-91 7.07e-03

DivIVA protein; The Bacillus subtilis divIVA1 mutation causes misplacement of the septum during cell division, resulting in the formation of small, circular, anucleate mini-cells. Inactivation of divIVA produces a mini-cell phenotype, whereas overproduction of DivIVA results in a filamentation phenotype. These proteins appear to contain coiled-coils.


Pssm-ID: 428304 [Multi-domain]  Cd Length: 131  Bit Score: 36.78  E-value: 7.07e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 966960707   60 ELFGQIEREFENLYIENLELRREIDTLNERLA 91
Cdd:pfam05103  25 EFLDQVAEDYEALIRENAELKEKIEELEEKLA 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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