|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02885 |
PLN02885 |
nicotinate phosphoribosyltransferase |
15-525 |
0e+00 |
|
nicotinate phosphoribosyltransferase
Pssm-ID: 178473 [Multi-domain] Cd Length: 545 Bit Score: 609.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPDTDPAFFE 94
Cdd:PLN02885 12 PLLTDLYQFTMAYAYWKAGKHLDRAVFDLFFRKNPFGGEYTVFAGLEECLRFIANFKFTDDDIDFLRSVMPSGCEDAFFD 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 95 HLRSLDCSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPEKRLLEMGLRRAQ 174
Cdd:PLN02885 92 YLRGLDCSDVEVYAIPEGSVVFPRVPLMRIEGPLAVVQLLETTFLTLVNYASLVATNAARHRLVAGKSKVLLEFGLRRAQ 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFSGSEVPPDPMLAPAAGEGPGVDLAAKAQVWLEHV- 253
Cdd:PLN02885 172 GPDGGISASKYCYLGGFDATSNVEAGRLFGIPVRGTHSHAFVSSYMGLDEIVDKTLRSADGSSVCEDFVSLVQEWLSKLq 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 254 -CAHLGLGVQEPHPGERAAFVAYALAFPQAFQGLLDSYSVRRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIR 332
Cdd:PLN02885 252 eSSSLRGVFSETNQSELAAFTSYALAFPNSFLALVDTYDVMKSGIPNFCAVALALNDLGYKAVGIRLDSGDLAYLSLEAR 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 333 KVFRAAAAQFQVPWLESVPIAVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGCVYKLVAVGGQPRMKLTEDP 412
Cdd:PLN02885 332 KFFRTIEEELGVPGFGKMSITASNDINEETLDALNKQGHEIDAFGIGTHLVTCYAQPALGCVYKLVEINGQPRIKLSEDV 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 413 EKQTLPGSKAAFRLLGSDGSLLMDVLQLAEEPAPQAGQelRVW---PPGAQEPCTVRPAQVEPLLRLCLQ--QGQLCEPL 487
Cdd:PLN02885 412 EKVTIPCKKRCYRLYGKEGYPLVDLMTGENEPPPKVGE--RILcrhPFNESKRAYVVPQRVEELLKCYWDgsSGKPREEL 489
|
490 500 510
....*....|....*....|....*....|....*...
gi 1622962147 488 PSLAESRALVQLSLSQLSPEHRRLQSPAQYQVVLSERL 525
Cdd:PLN02885 490 PSLKEIRERCMKQLERMRPDHMRRLNPTPYKVSVSAKL 527
|
|
| NAPRTase_put |
TIGR01513 |
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ... |
15-525 |
0e+00 |
|
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 273666 [Multi-domain] Cd Length: 443 Bit Score: 596.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVlpPDTDPAFFE 94
Cdd:TIGR01513 1 ALLTDLYELTMAQGYFREGKANQPAVFEVFFRKLPFGRGYAVFAGLEDLLEFLENFRFDAEDIEYLASL--GIFDDAFLD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 95 HLRSLDCSeVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPEKrLLEMGLRRAQ 174
Cdd:TIGR01513 79 YLREFRFS-GTVRALPEGSLVFPNEPLLQVEGPLIEAQLLETLVLNIINFQTLIATKAARIVLAAGGKP-LLEFGLRRAQ 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwlehvc 254
Cdd:TIGR01513 157 GPDAALKAARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSF----------------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 255 ahlglgvqephPGERAAFVAYALAFPQAFQGLLDSYSVRRSGLPNFLAVALALGELGYrAVGVRLDSGDLLQQAQEIRKV 334
Cdd:TIGR01513 202 -----------DNELAAFRAYAKLYPKATVLLVDTYDTLRSGLPNAIAVAKELGEQGK-VVGVRIDSGDLLYLSKQARKQ 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 335 FRAAAaqfqvpwLESVPIAVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGCVYKLVAVGGQPRMKLTEDPEK 414
Cdd:TIGR01513 270 LDAAG-------LTQVKIVVSNDLDENSIAALKAEGAPIDVYGVGTSLVTASDAPALGGVYKLVAYEGRPVMKLSENPEK 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 415 QTLPGSKAAFRLLGSDGSLLMDVLQLAEEPAPQAgqelrvwppgAQEPCTVRPAQVEPLLRLCLQQGQLCEPLPSLAESR 494
Cdd:TIGR01513 343 STLPGRKQVFRLYDATGKFLGDELTLADEPIEDL----------NQEKCTPVFAPVEPLLRLVMKNGQRVRPLPSLAEIR 412
|
490 500 510
....*....|....*....|....*....|.
gi 1622962147 495 ALVQLSLSQLSPEHRRLQSPAQYQVVLSERL 525
Cdd:TIGR01513 413 ARAREQLSKLPPEYLRLLNPHVYPVSLSPRL 443
|
|
| NAPRTase_A |
cd01570 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ... |
15-398 |
3.72e-161 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).
Pssm-ID: 238804 [Multi-domain] Cd Length: 327 Bit Score: 461.27 E-value: 3.72e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPdtDPAFFE 94
Cdd:cd01570 1 ALLTDLYQLTMAQAYWKEGKHNKPAVFELFFRKLPFGGGYAVFAGLEELLEYLENFRFTEEDIDYLRSLGIF--DEEFLD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 95 HLRSLDcSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPeKRLLEMGLRRAQ 174
Cdd:cd01570 79 YLRGFR-FTGTIYAIPEGEVVFPNEPLLTVEGPLIEAQLLETLLLNLINFQTLIATKAARVRLAAGG-RPLLEFGLRRAQ 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwlehvc 254
Cdd:cd01570 157 GPDAALSAARAAYIGGFDGTSNVLAGKLYGIPVSGTMAHSFVQAF----------------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 255 ahlglgvqephPGERAAFVAYALAFPQAFQGLLDSYSVRRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIRKV 334
Cdd:cd01570 202 -----------DDELAAFRAFAEAYPDNFTLLVDTYDTLRSGLPNAIAVAKELGALGYRLVGVRIDSGDLAYLSKEARKM 270
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622962147 335 FRAAAaqfqvpwLESVPIAVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGCVYKLV 398
Cdd:cd01570 271 LDEAG-------LTKVKIVASNDLDEYTIAALNAQGAPIDAFGVGTRLVTSQSQPALGGVYKLV 327
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
16-532 |
2.86e-135 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 399.52 E-value: 2.86e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 16 LLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVlpPDTDPAFFEH 95
Cdd:COG1488 6 LLTDLYKLTMAQAYLPEGTANRRAVFELFFRRLPFGRGYVVFAGLQRFLKYLENLRFTEEDIAYLRSL--GVFDEDFLDY 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 96 LRSLDCSeVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGpEKRLLEMGLRRAQG 175
Cdd:COG1488 84 LADFRFP-GDIRAVPEGTVVFPGEPLLTVEGTLPEAQLLETLLLNILNYPTLIATKAARIVQAAG-GRPLHDFGLRRAHG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 176 PDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSfsgsevppdpmlapaagegpgvdlaakaqvwlehvca 255
Cdd:COG1488 162 LEAAVAAARAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQA------------------------------------- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 256 hlglgvqepHPGERAAFVAYALAFPQAFQGLLDSYSVrRSGLPNflAVALAlGELG--YRAVGVRLDSGDLLQQAQEIRK 333
Cdd:COG1488 205 ---------HDDELEAFRAFAEAYPDGTTLLVDTYDT-LSGVPN--AIELA-KELLarGGLLGIRLDSGDLAYLSKQARE 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 334 VFRAAAaqfqvpwLESVPIAVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGCVYKLVAVGG----QPRMKLT 409
Cdd:COG1488 272 LLDEAG-------LPDVRIIASDDLDEYRIAALLEQGAPIDVFGVGTRLVTSSDRPTLGFVYKLVAVEGdgewRPVIKLS 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 410 EDPEKQTLPGSKAAFRlLGSDGSLLMDVLQLAEEPAPQAGqelrvwppgaqepctvrpaqvEPLLRLCLQQGQLCEPLPS 489
Cdd:COG1488 345 ETPGKKSKPGRKQVYR-RDEDGKATADLVALEDEPLPGEP---------------------EPLLVPVFRDGKLVYELPS 402
|
490 500 510 520
....*....|....*....|....*....|....*....|...
gi 1622962147 490 LAESRALVQLSLSQLSPEHRRLQSPAQYQVVLSERLQALVNSL 532
Cdd:COG1488 403 LEEIRERAAAQLAELPEELKRLRNPPAYPVDLSEALWDLKEQL 445
|
|
| NAPRTase_N |
pfam17767 |
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ... |
16-143 |
5.80e-46 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.
Pssm-ID: 465494 [Multi-domain] Cd Length: 125 Bit Score: 157.29 E-value: 5.80e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 16 LLTDLYQATMALGYWRAGRARDAaEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPdTDPAFFEH 95
Cdd:pfam17767 1 LDTDLYKLTMAQAYFKNGPDVQV-VFEFFNRTNPFGGLYAVFAGLEEQIEFLENLRFTEEEIEYLRRSLPY-FKPDFLDY 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1622962147 96 LRSLDCSEVTVrALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVS 143
Cdd:pfam17767 79 LRNFRFDPSIV-AVPEGEVVFPGEPLLRIEGPWLETILLETPLLAIVN 125
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02885 |
PLN02885 |
nicotinate phosphoribosyltransferase |
15-525 |
0e+00 |
|
nicotinate phosphoribosyltransferase
Pssm-ID: 178473 [Multi-domain] Cd Length: 545 Bit Score: 609.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPDTDPAFFE 94
Cdd:PLN02885 12 PLLTDLYQFTMAYAYWKAGKHLDRAVFDLFFRKNPFGGEYTVFAGLEECLRFIANFKFTDDDIDFLRSVMPSGCEDAFFD 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 95 HLRSLDCSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPEKRLLEMGLRRAQ 174
Cdd:PLN02885 92 YLRGLDCSDVEVYAIPEGSVVFPRVPLMRIEGPLAVVQLLETTFLTLVNYASLVATNAARHRLVAGKSKVLLEFGLRRAQ 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFSGSEVPPDPMLAPAAGEGPGVDLAAKAQVWLEHV- 253
Cdd:PLN02885 172 GPDGGISASKYCYLGGFDATSNVEAGRLFGIPVRGTHSHAFVSSYMGLDEIVDKTLRSADGSSVCEDFVSLVQEWLSKLq 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 254 -CAHLGLGVQEPHPGERAAFVAYALAFPQAFQGLLDSYSVRRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIR 332
Cdd:PLN02885 252 eSSSLRGVFSETNQSELAAFTSYALAFPNSFLALVDTYDVMKSGIPNFCAVALALNDLGYKAVGIRLDSGDLAYLSLEAR 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 333 KVFRAAAAQFQVPWLESVPIAVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGCVYKLVAVGGQPRMKLTEDP 412
Cdd:PLN02885 332 KFFRTIEEELGVPGFGKMSITASNDINEETLDALNKQGHEIDAFGIGTHLVTCYAQPALGCVYKLVEINGQPRIKLSEDV 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 413 EKQTLPGSKAAFRLLGSDGSLLMDVLQLAEEPAPQAGQelRVW---PPGAQEPCTVRPAQVEPLLRLCLQ--QGQLCEPL 487
Cdd:PLN02885 412 EKVTIPCKKRCYRLYGKEGYPLVDLMTGENEPPPKVGE--RILcrhPFNESKRAYVVPQRVEELLKCYWDgsSGKPREEL 489
|
490 500 510
....*....|....*....|....*....|....*...
gi 1622962147 488 PSLAESRALVQLSLSQLSPEHRRLQSPAQYQVVLSERL 525
Cdd:PLN02885 490 PSLKEIRERCMKQLERMRPDHMRRLNPTPYKVSVSAKL 527
|
|
| NAPRTase_put |
TIGR01513 |
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ... |
15-525 |
0e+00 |
|
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 273666 [Multi-domain] Cd Length: 443 Bit Score: 596.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVlpPDTDPAFFE 94
Cdd:TIGR01513 1 ALLTDLYELTMAQGYFREGKANQPAVFEVFFRKLPFGRGYAVFAGLEDLLEFLENFRFDAEDIEYLASL--GIFDDAFLD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 95 HLRSLDCSeVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPEKrLLEMGLRRAQ 174
Cdd:TIGR01513 79 YLREFRFS-GTVRALPEGSLVFPNEPLLQVEGPLIEAQLLETLVLNIINFQTLIATKAARIVLAAGGKP-LLEFGLRRAQ 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwlehvc 254
Cdd:TIGR01513 157 GPDAALKAARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSF----------------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 255 ahlglgvqephPGERAAFVAYALAFPQAFQGLLDSYSVRRSGLPNFLAVALALGELGYrAVGVRLDSGDLLQQAQEIRKV 334
Cdd:TIGR01513 202 -----------DNELAAFRAYAKLYPKATVLLVDTYDTLRSGLPNAIAVAKELGEQGK-VVGVRIDSGDLLYLSKQARKQ 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 335 FRAAAaqfqvpwLESVPIAVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGCVYKLVAVGGQPRMKLTEDPEK 414
Cdd:TIGR01513 270 LDAAG-------LTQVKIVVSNDLDENSIAALKAEGAPIDVYGVGTSLVTASDAPALGGVYKLVAYEGRPVMKLSENPEK 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 415 QTLPGSKAAFRLLGSDGSLLMDVLQLAEEPAPQAgqelrvwppgAQEPCTVRPAQVEPLLRLCLQQGQLCEPLPSLAESR 494
Cdd:TIGR01513 343 STLPGRKQVFRLYDATGKFLGDELTLADEPIEDL----------NQEKCTPVFAPVEPLLRLVMKNGQRVRPLPSLAEIR 412
|
490 500 510
....*....|....*....|....*....|.
gi 1622962147 495 ALVQLSLSQLSPEHRRLQSPAQYQVVLSERL 525
Cdd:TIGR01513 413 ARAREQLSKLPPEYLRLLNPHVYPVSLSPRL 443
|
|
| NAPRTase_A |
cd01570 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ... |
15-398 |
3.72e-161 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).
Pssm-ID: 238804 [Multi-domain] Cd Length: 327 Bit Score: 461.27 E-value: 3.72e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPdtDPAFFE 94
Cdd:cd01570 1 ALLTDLYQLTMAQAYWKEGKHNKPAVFELFFRKLPFGGGYAVFAGLEELLEYLENFRFTEEDIDYLRSLGIF--DEEFLD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 95 HLRSLDcSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPeKRLLEMGLRRAQ 174
Cdd:cd01570 79 YLRGFR-FTGTIYAIPEGEVVFPNEPLLTVEGPLIEAQLLETLLLNLINFQTLIATKAARVRLAAGG-RPLLEFGLRRAQ 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwlehvc 254
Cdd:cd01570 157 GPDAALSAARAAYIGGFDGTSNVLAGKLYGIPVSGTMAHSFVQAF----------------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 255 ahlglgvqephPGERAAFVAYALAFPQAFQGLLDSYSVRRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIRKV 334
Cdd:cd01570 202 -----------DDELAAFRAFAEAYPDNFTLLVDTYDTLRSGLPNAIAVAKELGALGYRLVGVRIDSGDLAYLSKEARKM 270
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622962147 335 FRAAAaqfqvpwLESVPIAVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGCVYKLV 398
Cdd:cd01570 271 LDEAG-------LTKVKIVASNDLDEYTIAALNAQGAPIDAFGVGTRLVTSQSQPALGGVYKLV 327
|
|
| PRK09243 |
PRK09243 |
nicotinate phosphoribosyltransferase; Validated |
15-525 |
3.16e-148 |
|
nicotinate phosphoribosyltransferase; Validated
Pssm-ID: 236426 [Multi-domain] Cd Length: 464 Bit Score: 433.43 E-value: 3.16e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASvlPPDTDPAFFE 94
Cdd:PRK09243 10 ALLTDLYELTMAQAYLRDGIHNRRAVFELFFRKLPFGRGYAVFAGLERLLEYLENLRFTEEDIEYLRS--LGIFDEDFLD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 95 HLRSLDCSEvTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGpEKRLLEMGLRRAQ 174
Cdd:PRK09243 88 YLRNFRFTG-DVRAVPEGELVFPNEPLLRVEGPLAEAQLLETLLLNIINFQTLIATKAARIVSAAG-GRPLLEFGSRRAQ 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSfsgsevppdpmlapaagegpgvdlaakaqvwlehvc 254
Cdd:PRK09243 166 GPDAAVWAARAAYIGGFDATSNVLAGKRYGIPVSGTMAHSFVQA------------------------------------ 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 255 ahlglgvqepHPGERAAFVAYALAFPQAFQGLLDSYSVRRSGLPNFLAVALALGElGYRAVGVRLDSGDLLQQAQEIRKV 334
Cdd:PRK09243 210 ----------FDDEYEAFRAYAETYPDNTVLLVDTYDTLKSGVPNAIKVAKELGD-GIELGGVRIDSGDLAYLSKKVRKM 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 335 FRAAAaqfqvpwLESVPIAVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGCVYKLVAVGG----QPRMKLTE 410
Cdd:PRK09243 279 LDEAG-------FTDTKIVASNDLDEYTIASLKLQGAPIDGFGVGTKLVTGSDAPALGGVYKLVAIEGeggmIPKIKLSN 351
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 411 DPEKQTLPGSKAAFRLLGSDGSLLMDVLQLAEEPaPQAGQELrVWPPGAQEPCTVRPAQVEPLLRLCLQQGQLCEPLPSL 490
Cdd:PRK09243 352 SPEKVTTPGRKQVYRIYDKGGKAEADVITLADEE-EEEPLKM-FHPVHTYKSKTVKNFDAEPLLVPVMENGKRVYELPSL 429
|
490 500 510
....*....|....*....|....*....|....*
gi 1622962147 491 AESRALVQLSLSQLSPEHRRLQSPAQYQVVLSERL 525
Cdd:PRK09243 430 EEIRAYAAAQLASLPEEYKRLLNPHAYPVDLSQAL 464
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
16-532 |
2.86e-135 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 399.52 E-value: 2.86e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 16 LLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVlpPDTDPAFFEH 95
Cdd:COG1488 6 LLTDLYKLTMAQAYLPEGTANRRAVFELFFRRLPFGRGYVVFAGLQRFLKYLENLRFTEEDIAYLRSL--GVFDEDFLDY 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 96 LRSLDCSeVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGpEKRLLEMGLRRAQG 175
Cdd:COG1488 84 LADFRFP-GDIRAVPEGTVVFPGEPLLTVEGTLPEAQLLETLLLNILNYPTLIATKAARIVQAAG-GRPLHDFGLRRAHG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 176 PDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSfsgsevppdpmlapaagegpgvdlaakaqvwlehvca 255
Cdd:COG1488 162 LEAAVAAARAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQA------------------------------------- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 256 hlglgvqepHPGERAAFVAYALAFPQAFQGLLDSYSVrRSGLPNflAVALAlGELG--YRAVGVRLDSGDLLQQAQEIRK 333
Cdd:COG1488 205 ---------HDDELEAFRAFAEAYPDGTTLLVDTYDT-LSGVPN--AIELA-KELLarGGLLGIRLDSGDLAYLSKQARE 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 334 VFRAAAaqfqvpwLESVPIAVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGCVYKLVAVGG----QPRMKLT 409
Cdd:COG1488 272 LLDEAG-------LPDVRIIASDDLDEYRIAALLEQGAPIDVFGVGTRLVTSSDRPTLGFVYKLVAVEGdgewRPVIKLS 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 410 EDPEKQTLPGSKAAFRlLGSDGSLLMDVLQLAEEPAPQAGqelrvwppgaqepctvrpaqvEPLLRLCLQQGQLCEPLPS 489
Cdd:COG1488 345 ETPGKKSKPGRKQVYR-RDEDGKATADLVALEDEPLPGEP---------------------EPLLVPVFRDGKLVYELPS 402
|
490 500 510 520
....*....|....*....|....*....|....*....|...
gi 1622962147 490 LAESRALVQLSLSQLSPEHRRLQSPAQYQVVLSERLQALVNSL 532
Cdd:COG1488 403 LEEIRERAAAQLAELPEELKRLRNPPAYPVDLSEALWDLKEQL 445
|
|
| PRK12484 |
PRK12484 |
nicotinate phosphoribosyltransferase; Provisional |
16-537 |
1.01e-103 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 237112 [Multi-domain] Cd Length: 443 Bit Score: 318.61 E-value: 1.01e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 16 LLTDLYQATMALGYWRAGrARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLP-PDTDPAFFE 94
Cdd:PRK12484 6 LLTDLYEVTMANAYLREG-MSAPATFSLFYRKLPDGRGFLIAAGLADVVEFLEAFRFDEQDLRYLRGLNQfSEEFLAWLA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 95 HLRsLDCSevtVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLiAGPEKRLLEMGLRRAQ 174
Cdd:PRK12484 85 GLR-FTGD---VRAVPEGTVVFPNEPLLEVTAPLIEAQLVETFLLNQINHQSLIASKAARCVL-AAAGRPVVDFGARRAH 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwlehvc 254
Cdd:PRK12484 160 GTDAACYVARASYLAGAAGTSNVLAARQYGIPASGTMAHSFVEAF----------------------------------- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 255 ahlglgvqephPGERAAFVAYALAFPQAFQGLLDSYSVRRsGLPNFLAVALALGElGYRAVGVRLDSGDLLQQAQEIRKV 334
Cdd:PRK12484 205 -----------PDEVAAFRAFARLYPDATTLLVDTYDTLR-GVRNAIEVAKELGN-RFDPRGVRLDSGDLAELSKATRAI 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 335 FRAAAaqfqvpwLESVPIAVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGCVYKLVAVGGQPRMKLTedPEK 414
Cdd:PRK12484 272 LDAAG-------LEQVKIVASGGLDEYRIAALLAAGAPIDGFGVGTRLGVAADAPVLDSAYKLVAYEGRGVTKLS--SGK 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 415 QTLPGSKAAFRLLGSdGSLLMDVLQLAEEPApqagqelrvwPPGAqepctvrpaqvEPLLRLCLQQGQLCEPLPSLAESR 494
Cdd:PRK12484 343 VTYPGRKQVFRLYEH-GTACGDVIGLHTENI----------PDGR-----------EPLLVPVMTNGRRIQHAPTLDGAR 400
|
490 500 510 520
....*....|....*....|....*....|....*....|...
gi 1622962147 495 ALVQLSLSQLSPEHRRLQSPAQYQVVLSERLQALVNSLHARAS 537
Cdd:PRK12484 401 DWCEAQLAALPPEARRLVDPVAVSVTLSGELARLRHADTAEAH 443
|
|
| NAPRTase_PncB |
cd01567 |
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase ... |
15-396 |
4.51e-97 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.
Pssm-ID: 238801 [Multi-domain] Cd Length: 343 Bit Score: 298.03 E-value: 4.51e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 15 PLLTDLYQATMALGYWrAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPpdtDPAFFE 94
Cdd:cd01567 1 LLDTDLYKLTMMQAYL-YPYPNTRVVFEFTFRSNPFGGDYIVFAGLEEVLKLLENLRFTEEEIEYLKKLLI---FGEFFL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 95 HLRSLDCSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAG-----------PEK 163
Cdd:cd01567 77 YLLFLGKLPLEIYALPEGTVVFPKEPLLTIEGPWPEAGLLETPLLAIWNEATSIATKAARKKLAAGglletkdnleeLGF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 164 RLLEMGLRRAQGPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFSGSEVppdpmlapaagegpgvdla 243
Cdd:cd01567 157 KLHDFGTRRRHSPEAALSGGRAALIGGFGGTSNVAAAKKLGIPPIGTMAHSWIQAFGALEE------------------- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 244 akaqvwlehvcahlglgvqephpgerAAFVAYALAFPQAFQGLL----DSYSVRRsGLPNFLAVALALGElGYRAVGVRL 319
Cdd:cd01567 218 --------------------------AAFEAFARWLPQFGGGLGialiDTYDTDN-GFLNALKLAKALGA-GGGLLGVRL 269
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622962147 320 DSGDLLQQAQEIRKVFRAAAAqfqvpWLESVPIAVSNNID-EEALARL-AQEGSEVNVIGIGTSVVTCPQQPSLGCVYK 396
Cdd:cd01567 270 DSGDPVELIKKVRKHLDELGI-----DLNKKKIIISGDLDtEEAIELLlEQGASPNDAFGVGTSLTNDLGRPPLGFVYK 343
|
|
| PRTase_typeII |
cd00516 |
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an ... |
19-396 |
1.52e-54 |
|
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate phosphoribosyltransferase (NAPRTase), to be used in the synthesis of NAD. QAPRTase catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide, an important step in the de novo synthesis of NAD. NAPRTase catalyses a similar reaction leading to NAMN and pyrophosphate, using nicotinic acid an PPRP as substrates, used in the NAD salvage pathway.
Pssm-ID: 238286 [Multi-domain] Cd Length: 281 Bit Score: 185.52 E-value: 1.52e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 19 DLYQATMALGYwraGRARDAAEFELFFRRCPFGgafaLAAGLRDCVRFLRAFRLRDAdvqflasvlppdtdpaffehlrs 98
Cdd:cd00516 1 DLYKLTMIQAY---PPPDTRATAEFTAREDPYG----VLAGLEEALELLELLRFPGP----------------------- 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 99 ldcseVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIA-GPEKRLLEMGLRRAQgPD 177
Cdd:cd00516 51 -----LVILAVPEGTVVEPGEPLLTIEGPARELLLLERVLLNLLQRLSGIATATARYVEAAkGANTKVHDFGTRKTT-PG 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 178 GGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwlehvcahl 257
Cdd:cd00516 125 LRLLEKYAVLIGGGDGHRNGLSDAILIKDNHGTMAHSIIQAF-------------------------------------- 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 258 glgvqephpGERAAFVAYALAFPQAFQGLLDSYSvrrSGLPNFLAVALALgelgyRAVGVRLDSGDL--LQQAQEIRKVF 335
Cdd:cd00516 167 ---------GELAAVKALRRWLPELFIALIDVEV---DTLEEALEAAKAG-----GADGIRLDSGSPeeLDPAVLILKAR 229
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622962147 336 RAaaaqFQVPWLESVPIAVSNNIDEEALARLAQEGseVNVIGIGTSVVTCpqqPSLGCVYK 396
Cdd:cd00516 230 AH----LDGKGLPRVKIEASGGLDEENIRAYAETG--VDVFGVGTLLHSA---PPLDIVLK 281
|
|
| NAPRTase_N |
pfam17767 |
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ... |
16-143 |
5.80e-46 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.
Pssm-ID: 465494 [Multi-domain] Cd Length: 125 Bit Score: 157.29 E-value: 5.80e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 16 LLTDLYQATMALGYWRAGRARDAaEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPdTDPAFFEH 95
Cdd:pfam17767 1 LDTDLYKLTMAQAYFKNGPDVQV-VFEFFNRTNPFGGLYAVFAGLEEQIEFLENLRFTEEEIEYLRRSLPY-FKPDFLDY 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1622962147 96 LRSLDCSEVTVrALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVS 143
Cdd:pfam17767 79 LRNFRFDPSIV-AVPEGEVVFPGEPLLRIEGPWLETILLETPLLAIVN 125
|
|
| NAPRTase_C |
pfam17956 |
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus ... |
421-528 |
1.65e-30 |
|
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus of some Nicotinate phosphoribosyltransferase enzymes. The function of this domain is uncertain.
Pssm-ID: 465585 [Multi-domain] Cd Length: 111 Bit Score: 114.97 E-value: 1.65e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 421 KAAFRLLGSDGSLLMDVLQLAEEPAPQAGQELRVWPPGA-QEPCTVRPAQVEPLLRLCLQQGQLCEPLPSLAESRALVQL 499
Cdd:pfam17956 2 KQVYRLYDKDGKAIADLITLADEPPPDPGEEILCFHPFDeWKRKTVTPFTVEPLLKPVFEDGKLVYELPTLEEIRAYVQE 81
|
90 100
....*....|....*....|....*....
gi 1622962147 500 SLSQLSPEHRRLQSPAQYQVVLSERLQAL 528
Cdd:pfam17956 82 QLSRLWPEHKRLLNPHPYKVDLSEKLYQL 110
|
|
| NAPRTase_B |
cd01571 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate ... |
94-407 |
1.31e-25 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.
Pssm-ID: 238805 [Multi-domain] Cd Length: 302 Bit Score: 106.97 E-value: 1.31e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 94 EHLRSLDCSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGpEKRLLEMGLRR- 172
Cdd:cd01571 43 EVLALLEGLPVKVYALPEGTIFNPKEPVLRIEGPYQDFGELETAILGILARASSIATNAARVKLAAG-DKPVISFGDRRd 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 173 --AQGPDGGLTAstysYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFSGSEVppdpmlapaagegpgvdlaakaqvwl 250
Cdd:cd01571 122 hpAIQPMDGRAA----YIGGCDGVSTVLGAELLGEKPSGTMPHALIQIFGGDQV-------------------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 251 ehvcahlglgvqephpgerAAFVAYALAFPQAFQ--GLLDSYSVRRsglpnfLAVALALGELGYRAVGVRLDS-----GD 323
Cdd:cd01571 172 -------------------EAWKAFDETYPEDVPriALIDTFNDEK------EEALKAAKALGDKLDGVRLDTpssrrGV 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 324 LLQQAQEIRKVFRAAAAQfqvpwleSVPIAVSNNIDEEALARLAQEGseVNVIGIGTSVVTCpqqPSLGCVYKLVAVGGQ 403
Cdd:cd01571 227 FRYLIREVRWALDIRGYK-------HVKIFVSGGLDEEDIKELEDVG--VDAFGVGTAISKA---PPVDFTMDIVEVNGQ 294
|
....
gi 1622962147 404 PRMK 407
Cdd:cd01571 295 PIAK 298
|
|
| PRK08662 |
PRK08662 |
nicotinate phosphoribosyltransferase; Reviewed |
103-382 |
6.50e-19 |
|
nicotinate phosphoribosyltransferase; Reviewed
Pssm-ID: 236328 [Multi-domain] Cd Length: 343 Bit Score: 88.01 E-value: 6.50e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 103 EVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGpEKRLLEMGLRR---AQGPdgg 179
Cdd:PRK08662 69 PVDVYALPEGTLFDPKEPVMRIEGPYLEFGIYETALLGILAHASGIATAAARCKEAAG-DKPVLSFGARHvhpAIAP--- 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 180 lTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsGSEVppdpmlapaagegpgvdLAAKAqvWLEHVcahlgl 259
Cdd:PRK08662 145 -MMDRAAYIGGCDGVSGVLGAELLGIEPSGTMPHALILIF-GDQV-----------------EAWKA--FDEVV------ 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 260 gvqephPGE--RAAfvayalafpqafqgLLDSYSVRRSglpNFLAVALALGElgyRAVGVRLDS-----GDLLQQAQEIR 332
Cdd:PRK08662 198 ------PPDvpRIA--------------LVDTFKDERE---EALRAAEALGD---RLDGVRLDTpssrrGNFRKIVREVR 251
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1622962147 333 KVFRAAAaqfqvpwLESVPIAVSNNIDEEALARLAQegsEVNVIGIGTSV 382
Cdd:PRK08662 252 WTLDIRG-------YEHVKIFVSGGLDPERIRELRD---VVDGFGVGTYI 291
|
|
| PncB_like |
cd01401 |
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate ... |
14-416 |
9.99e-10 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria, archea and funghi.
Pssm-ID: 238695 [Multi-domain] Cd Length: 377 Bit Score: 60.34 E-value: 9.99e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 14 RPLL-TDLYQATMALGYWRA-GRARDAAEF-----ELFFRRcpfggafaLAAGLRDCVRFLRAFRLRDADVQFLASVLPP 86
Cdd:cd01401 1 RSLLdTDLYKLTMQQAVLHHyPDVQVTYEFtnrspEDFLEE--------AAEALREQIDHLANLRFSEEELAYLRRSLPF 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 87 DTdPAFFEHLRS--LDCSEVTVRA-LPEGSLAfpgvplLQVSGPLLVVQLLETPLLCLVS--YASLVATNA--------- 152
Cdd:cd01401 73 LK-PDYLDYLELfrLNPEEVVVRLdTGKGQLD------IRISGPWKDTILYEVPLLAIVSevYFRFRDADWdyeeqlekl 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 153 --------ARLRLIAGPEKRLLEMGLRRAQGPD------GGLTASTYSYLGGfdsSSNVLAGQLRGVPVAGTLAHsfvts 218
Cdd:cd01401 146 eeklerllEEAKRRDLNGFRFSDFGTRRRFSYEvqetvlKGLKQAAPGYLTG---TSNVHFAMKYGLTPIGTVAH----- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 219 fsgsevppdpmlapaagegpgvdlaakaqvwlEHVCAHLGLGVQEPHpGERAAFVAYAlafpQAFQGLL-----DSYsvr 293
Cdd:cd01401 218 --------------------------------EWFMAHQALTGDLKD-SQKAALERWV----REYGGDLgialtDTF--- 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 294 rsGLPNFLAVALAlgELGYRAVGVRLDSGDLLQQAQEIRKvfraaaaqfqvpWLESVPIA-------VSNNIDEEA---L 363
Cdd:cd01401 258 --GTDAFLRDFDL--YFAKLFDGVRHDSGDPFEWGEKAIA------------HYEKLGIDpktktlvFSDGLDVEKaleL 321
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 1622962147 364 ARLAQEGseVNVI-GIGTS----VVTCPQQPSLGCVYKLVAVGGQPRMKLTEDPEKQT 416
Cdd:cd01401 322 YEYFKGR--IKVSfGIGTNltndFGNKEKSTPLNIVIKLVECNGRPVAKISDSPGKNM 377
|
|
| PRK05321 |
PRK05321 |
nicotinate phosphoribosyltransferase; Provisional |
14-416 |
4.30e-09 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 235406 [Multi-domain] Cd Length: 400 Bit Score: 58.62 E-value: 4.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 14 RPLL-TDLYQATMALGYWRagRARDA-AEFELffrRCPFGGAFA--LAAGLRDCVRFLRAFRLRDADVQFLAS--VLPPD 87
Cdd:PRK05321 10 RSLLdTDFYKLTMQQAVLH--HYPDAqVEYEF---ICRNDEVDLaeYIDEIREQLDHLCTLRLTDDELDYLRGlpFFKPD 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 88 tdpaFFEHLRS--LDCSEVTVRAlPEGSLAfpgvplLQVSGPLLVVQLLETPLLCLVS-----YASLVATNA---ARL-- 155
Cdd:PRK05321 85 ----FLDWLRLfrLNPYEVTVSI-DDGQLD------IRIEGPWLETILWEVPLLAIISelyfrARSPEVLYAqakRRLwe 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 156 ---RLIAGPEK---RLLEMGLRRaqgpdggltasTYSYL--------------GGFDSSSNVLAGQLRGVPVAGTLAHSF 215
Cdd:PRK05321 154 kieLLKALPDLsgfKIADFGTRR-----------RFSFEwqeevvealkeglpGAFVGTSNVHLAMKLGLTPIGTMAHEW 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 216 vtsfsgsevppdPMLapAAGEGPGVDLAAKA--QVWLEHVCAHLGlgvqephpgeraafVAyalafpqafqgLLDSYsvr 293
Cdd:PRK05321 223 ------------FMA--HQALGPRLRDSQYAalEDWVREYRGDLG--------------IA-----------LTDTI--- 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622962147 294 rsGLPNFLA-VALALGELgYraVGVRLDSGDLLQQAQEIrkvfraaaaqfqVPWLESVPI------AV-SNNID-EEALA 364
Cdd:PRK05321 261 --GMDAFLRdFDLYFAKL-F--DGLRHDSGDPIEWGEKA------------IAHYEKLGIdprtktLVfSDGLDfDKALE 323
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 1622962147 365 RLAQEGSEVNVI-GIGTSvVTC--PQQPSLGCVYKLVAVGGQPRMKLTEDPEKQT 416
Cdd:PRK05321 324 LYRHFKGRIKLSfGIGTN-LTNdfPGVKPLNIVIKLVECNGRPVAKLSDSPGKTM 377
|
|
| PRK09198 |
PRK09198 |
putative nicotinate phosphoribosyltransferase; Provisional |
104-158 |
3.51e-04 |
|
putative nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 236407 [Multi-domain] Cd Length: 463 Bit Score: 43.34 E-value: 3.51e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1622962147 104 VTVRALPEGSLAFPGVPLLQVSG--PLL--VVQLLETPLLCLVSYASLVATNAARLRLI 158
Cdd:PRK09198 98 LRIKAVPEGSVVPVHNVLMTIENtdPEFfwLPNYLETLLLRNVWYPSTVATISWEYKQL 156
|
|
| |
