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Conserved domains on  [gi|966960250|ref|XP_015001591|]
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lymphocyte antigen 6K isoform X1 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_Ly6K cd23550
extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K ...
 41-126 3.40e-43

extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K is required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida. It may play a role in cell growth. Ly-6K contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467080  Cd Length: 86  Bit Score: 138.21  E-value: 3.40e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960250  41 VWCHVCERENTFECENPRRCQWTEPYCVIAAVKIFPRFFIISKQCSASCAAIEIPKPEEKRFLLEEPLPFFYLKCCKTRY 120
Cdd:cd23550    1 LTCHVCEVENSFNCTNPVTCTWEETYCVLAAVRIFPRFFLVSKQCSKYCPVVEVPPPPPKSFVLEKPMPFLYIKCCRENL 80


                 ....*.
gi 966960250 121 CNLQGP 126
Cdd:cd23550   81 CNEEGP 86
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6K cd23550
extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K ...
 41-126 3.40e-43

extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K is required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida. It may play a role in cell growth. Ly-6K contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467080  Cd Length: 86  Bit Score: 138.21  E-value: 3.40e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960250  41 VWCHVCERENTFECENPRRCQWTEPYCVIAAVKIFPRFFIISKQCSASCAAIEIPKPEEKRFLLEEPLPFFYLKCCKTRY 120
Cdd:cd23550    1 LTCHVCEVENSFNCTNPVTCTWEETYCVLAAVRIFPRFFLVSKQCSKYCPVVEVPPPPPKSFVLEKPMPFLYIKCCRENL 80


                 ....*.
gi 966960250 121 CNLQGP 126
Cdd:cd23550   81 CNEEGP 86
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6K cd23550
extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K ...
 41-126 3.40e-43

extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K is required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida. It may play a role in cell growth. Ly-6K contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467080  Cd Length: 86  Bit Score: 138.21  E-value: 3.40e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960250  41 VWCHVCERENTFECENPRRCQWTEPYCVIAAVKIFPRFFIISKQCSASCAAIEIPKPEEKRFLLEEPLPFFYLKCCKTRY 120
Cdd:cd23550    1 LTCHVCEVENSFNCTNPVTCTWEETYCVLAAVRIFPRFFLVSKQCSKYCPVVEVPPPPPKSFVLEKPMPFLYIKCCRENL 80


                 ....*.
gi 966960250 121 CNLQGP 126
Cdd:cd23550   81 CNEEGP 86
TFP_LU_ECD_GML cd23555
extracellular domain (ECD) found in glycosyl-phosphatidylinositol-anchored molecule-like ...
 43-126 6.97e-09

extracellular domain (ECD) found in glycosyl-phosphatidylinositol-anchored molecule-like protein (GML) and similar proteins; GML may play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. It contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467085  Cd Length: 87  Bit Score: 50.45  E-value: 6.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960250  43 CHVCERENTFECENPRRCQWTEPYCVIAAVKIFPRFFIISKQCSASCAAI-EIPKPEEKRFLLEEPLPFFYLKCCKTRYC 121
Cdd:cd23555    3 CHSCAVINTFNCPAHRTCPYDIRRCMTVAIRVNSRELLVYKNCTKNCTFVyAEEQPPEAPRKIPKTNSFYFVMCCSSMFC 82


                 ....*
gi 966960250 122 NLQGP 126
Cdd:cd23555   83 NEGGP 87
TFP_LU_ECD_Ly6E cd23543
extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E ...
 42-122 2.88e-04

extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E (also called retinoic acid-induced gene E protein (RIG-E), or stem cell antigen 2 (SCA-2), or thymic shared antigen 1 (TSA-1)) is a GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. It restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. It plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). It may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. Ly-6E contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467073  Cd Length: 78  Bit Score: 37.72  E-value: 2.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960250  42 WCHVCERENT-FECENPRRCQWTEPYCV--IAAVKIFPRF-FIISKQCSASCaaieipkPEEKRFLLEEPlpfFYLKCCK 117
Cdd:cd23543    4 YCYTCENQSSnWNCLKPTKCSDNDKYCVttVASGGTGSSSgVRITKKCSPKC-------PETNVNIGIAS---VSTSCCQ 73


                 ....*
gi 966960250 118 TRYCN 122
Cdd:cd23543   74 SSLCN 78
TFP_LU_ECD_Ly6D cd23542
extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D ...
 43-122 9.96e-04

extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D (also called E48 antigen) is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion. It may act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Ly-6D contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467072  Cd Length: 79  Bit Score: 36.24  E-value: 9.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960250  43 CHVCEreNTFECENPRRCQWTEPYCVIaAVKIFPRFFIISKQCSASCAaieipkPEEKRFLLEEPLPffYLKCCKTRYCN 122
Cdd:cd23542    8 CHVCN--SSSNCTNPVNCEGSERYCKT-TTVVQPSGNLVKKGCAETCP------PSTSRQQVGSGIS--SVTCCQGDLCN 76
TFP_LU_ECD_SLURP2 cd23561
extracellular domain (ECD) found in Secreted Ly-6/uPAR-related protein 2 (SLURP-2) and similar ...
 41-122 8.48e-03

extracellular domain (ECD) found in Secreted Ly-6/uPAR-related protein 2 (SLURP-2) and similar proteins; SLURP-2 (also called Lynx1, or secreted Ly-6/uPAR domain-containing protein 2, or secreted LY6/PLAUR domain-containing protein 2) binds and may modulate the functional properties of nicotinic and muscarinic acetylcholine receptors. It may regulate keratinocytes proliferation, differentiation, and apoptosis. In vitro SLURP-2 moderately inhibits ACh-evoked currents of alpha-3:beta-2-containing nAChRs and strongly inhibits alpha-4:beta-2-containing nAChRs, modulates alpha-7-containing nAChRs, and inhibits nicotine-induced signaling probably implicating alpha-3:beta-4-containing nAChRs. It may act on alpha-3:beta-2 and alpha-7 nAChRs in an orthosteric, and on mAChRs, such as CHRM1 and CHRM3, in an allosteric manner. SLURP-2 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467091  Cd Length: 75  Bit Score: 33.77  E-value: 8.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966960250  41 VWCHVCERENTfeCENPRRCQWTEPYCVIAAVKI---FPRFFIISKQCSASCaaieipkPEEKRFLLEeplPFFYLKCCK 117
Cdd:cd23561    1 IWCHQCTGFGG--CSHGSRCPRDSTHCVTTATRVlsnTEDLPLVTKMCHIGC-------PDIPSLGLG---PYVSIACCQ 68


                 ....*
gi 966960250 118 TRYCN 122
Cdd:cd23561   69 TSLCN 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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